keyword
https://read.qxmd.com/read/38534376/effects-of-diabetes-mellitus-on-corneal-immune-cell-activation-and-the-development-of-keratopathy
#21
JOURNAL ARTICLE
Pier Luigi Surico, Akitomo Narimatsu, Katayoon Forouzanfar, Rohan Bir Singh, Sara Shoushtari, Reza Dana, Tomas Blanco
Diabetes mellitus (DM) is one of the most prevalent diseases globally, and its prevalence is rapidly increasing. Most patients with a long-term history of DM present with some degree of keratopathy (DK). Despite its high incidence, the underlying inflammatory mechanism of DK has not been elucidated yet. For further insights into the underlying immunopathologic processes, we utilized streptozotocin-induced mice to model type 1 DM (T1D) and B6.Cg-Lepob/J mice to model type 2 DM (T2D). We evaluated the animals for the development of clinical manifestations of DK...
March 18, 2024: Cells
https://read.qxmd.com/read/38533487/pediatric-corneal-transplantation-techniques-challenges-and-outcomes
#22
REVIEW
Bharat Gurnani, Kirandeep Kaur, Sameer Chaudhary, Ruminder Preet Kaur, Swatishree Nayak, Deepak Mishra, Harinikrishna Balakrishnan, Rohit Om Parkash, Arvind Kumar Morya, Amit Porwal
Pediatric corneal transplant is a highly demanding and technically challenging procedure for the cornea surgeon in today's era. These cases pose unique challenges in clinical and surgical management. The indications of pediatric corneal transplant can be therapeutic, tectonic, optical, and cosmetic. Pediatric patients undergoing corneal transplants are at a high risk of graft infection, failure, rejection, dehiscence, and amblyopia due to young age, robust immune system, increased incidence of trauma, and compliance issues...
2024: Therapeutic Advances in Ophthalmology
https://read.qxmd.com/read/38533162/atypical-presentation-of-wilson-disease-unravelling-a-clinical-and-radiological-complexity-in-a-rare-case
#23
Keta Vagha, Sham Lohiya, Jayant D Vagha, Priyanka Hampe, Ajinkya Wazurkar, Aashita Malik, Chaitanya Kumar Javvaji, Pankaj Banode
Wilson disease (WD) is an autosomal recessive disorder marked by aberrations in copper metabolism, leading to its accumulation in vital organs such as the liver, brain, cornea, kidneys, and heart. While WD typically presents with hepatic symptoms in early childhood, neuropsychiatric manifestations are more prevalent during adolescence. This case report highlights an extraordinary instance of WD in an eight-year-old girl, characterized by intricate clinical and radiological features. The patient exhibited atypical symptoms, emphasizing the importance of recognizing diverse presentations of WD...
February 2024: Curēus
https://read.qxmd.com/read/38532334/epithelial-ingrowth-in-descemet-membrane-endothelial-keratoplasty-associated-with-vitreous-loss
#24
JOURNAL ARTICLE
Anny M S Cheng, Anup Kubal, Shailesh K Gupta, Anil S Vedula, David T Y Yang, Aarup A Kubal
BACKGROUND: Epithelial ingrowth is a rare but potentially sight-threatening complication caused by the invasion of corneal or conjunctival epithelial cells into the eye during ocular surgeries. DMEK is emerging as a widely used surgery for endothelial keratoplasty with its improved safety profile. We describe a case of epithelial ingrowth in the graft-host interface after uneventful DMEK associated with vitreous prolapse in the anterior chamber. CASE PRESENTATION: An 81-year-old female with Fuchs endothelial dystrophy underwent DMEK for corneal decompensation following cataract surgery...
March 26, 2024: BMC Ophthalmology
https://read.qxmd.com/read/38531435/postoperative-hyphema-due-to-persistent-tunica-vasculosa-lentis-in-glaucoma-associated-with-neurofibromatosis-a-case-report
#25
Nader Bayoumi, Nihal El Shakankiry
An 8-month-old girl referred from her pediatrician with a diagnosis of neurofibromatosis type 1 (NF1) presented with an enlarged cloudy cornea of the left eye and a swollen left side of the face. Her left eye had intraocular pressure (IOP) of 21 mm Hg, corneal diameter of 16 mm, ectropion uvea, cup:disk ratio of 0.9, axial length of 28.06 mm, and S-shaped upper lid deformity. Uneventful combined trabeculotomy-trabeculectomy with mitomycin C was performed. On postoperative day 1, there was a new total hyphema that persisted for 2 weeks...
March 24, 2024: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://read.qxmd.com/read/38529836/comparison-of-conjunctival-pedicle-flap-to-corneal-fixation-strength-achieved-by-tisseel%C3%A2-fibrin-glue-ethyl-cyanoacrylate-adhesive-resure%C3%A2-hydrogel-sealant-and-conventional-suturing-with-8-0-vicryl%C3%A2-ophthalmic-suture
#26
JOURNAL ARTICLE
Elodie M VerHulst, Roxanne M Rodriguez Galarza, Ian P Herring, Renata Velloso Ramos, Andrew R Kemper
OBJECTIVE: To determine and compare the fixation strength of conjunctival pedicle flaps to cornea achieved via conventional ophthalmic suture and three different adhesive compounds. ANIMALS STUDIED: Ex vivo porcine globes. PROCEDURES: Following a 6 mm wide 500-micron-restricted depth lamellar keratectomy, conjunctival pedicle flaps were secured to the keratectomy site with either 8-0 VICRYL® suture or one of three adhesive products, including Tisseel® bioadhesive, ReSure® synthetic adhesive, or ethyl cyanoacrylate adhesive (n = 10 per surgical group)...
March 26, 2024: Veterinary Ophthalmology
https://read.qxmd.com/read/38529825/diamond-burr-debridement-of-calcific-band-keratopathy-in-24-eyes-of-22-horses
#27
JOURNAL ARTICLE
Sophie Jugant, Alain Regnier, Jean-Yves Douet
PURPOSE: To evaluate the safety and effectiveness of diamond burr debridement (DBD) for the treatment of calcific band keratopathy (CBK) in horses. METHODS: Medical records from horses with CBK were reviewed over a period of 4 years. Diagnosis of CBK was based on slit-lamp examination findings, and DBD was performed on standing sedated horses. Follow-up was obtained by clinical reevaluation of the treated eyes or a telephone survey with the referring veterinarian...
March 26, 2024: Veterinary Ophthalmology
https://read.qxmd.com/read/38529047/identification-and-validation-of-the-pyroptosis-related-hub-gene-signature-and-the-associated-regulation-axis-in-diabetic-keratopathy
#28
JOURNAL ARTICLE
Yi Cui, Li Wang, Wentao Liang, Li Huang, Shuting Zhuang, Hong Shi, Nuo Xu, Jianzhang Hu
BACKGROUND: Diabetic keratopathy (DK) poses a significant challenge in diabetes mellitus, yet its molecular pathways and effective treatments remain elusive. The aim of our research was to explore the pyroptosis-related genes in the corneal epithelium of the streptozocin-induced diabetic rats. METHODS: After sixteen weeks of streptozocin intraperitoneal injection, corneal epithelium from three diabetic rats and three normal groups underwent whole-transcriptome sequencing...
2024: Journal of Diabetes Research
https://read.qxmd.com/read/38527771/structural-and-functional-changes-of-binocular-corneal-innervation-and-ocular-surface-function-after-unilateral-smile-and-tprk
#29
JOURNAL ARTICLE
Qianwen Gong, Kaiyan Huang, Kexin Li, Yixuan Tong, Jian Zhao, Hui Wang, Zhiqiang Xu, Meng Lin, Fan Lu, Liang Hu
AIMS: To evaluate the bilateral changes in the sub-basal nerve plexus of the cornea and ocular surface function after unilateral small incision lenticule extraction (SMILE) and transepithelial photorefractive keratectomy (tPRK) procedures. METHODS: 34 patients were enrolled in the study and underwent unilateral SMILE (21 of 34 patients) or unilateral tPRK (13 of 34 patients). Complete ophthalmic examinations, tear film function tests and Cochet-Bonnet esthesiometry were conducted to assess the effects of the surgeries on the corneal nerves and tear function...
March 25, 2024: British Journal of Ophthalmology
https://read.qxmd.com/read/38527222/fusion-flanged-intrascleral-intraocular-lens-fixation-technique-simple-safe-efficient
#30
JOURNAL ARTICLE
Pratan Piyasoonthorn, Puntanarach Gacivut
PURPOSE: To develop a new, sutureless intrascleral intraocular lens (IOL) fixation technique based on the Yamane double-needle and Canabrava 4-flanged techniques. METHODS: The Fusion-Flanged technique involves using a 7-0 polypropylene suture loop threaded through the eyelets of the IOL. Afterward, both ends of the suture are passed outside the eye through a 27-gauge needle. This technique creates a single flange by joining the 2 suture ends through handheld cautery, and this flange is then embedded into the scleral tunnel to securely fix the IOL in place...
March 21, 2024: Cornea
https://read.qxmd.com/read/38527059/chitosan-nanoparticles-improve-the-effectivity-of-miltefosine-against-acanthamoeba
#31
JOURNAL ARTICLE
Alireza Latifi, Fariba Esmaeili, Mehdi Mohebali, Setayesh Yasami-Khiabani, Mostafa Rezaeian, Mohammad Soleimani, Elham Kazemirad, Amir Amani
BACKGROUND: Acanthamoeba keratitis (AK) is a corneal sight-threatening infection caused by the free-living amoebae of the genus Acanthamoeba. Early and appropriate treatment significantly impacts visual outcomes. Mucoadhesive polymers such as chitosan are a potential strategy to prolong the residence time and bioavailability of the encapsulated drugs in the cornea. Regarding the recent administration of miltefosine (MF) for treating resistant AK, in the present study, we synthesized miltefosine-loaded chitosan nanoparticles (MF-CS-NPs) and evaluated them against Acanthamoeba...
March 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38526612/a-muscarinic-receptor-antagonist-reverses-multiple-indices-of-diabetic-peripheral-neuropathy-preclinical-and-clinical-studies-using-oxybutynin
#32
RANDOMIZED CONTROLLED TRIAL
Carolina M Casselini, Henri K Parson, Katie E Frizzi, Alex Marquez, Darrell R Smith, Lucie Guernsey, Rakesh Nemmani, Alireza Tayarani, Corinne G Jolivalt, Jessica Weaver, Paul Fernyhough, Aaron I Vinik, Nigel A Calcutt
Preclinical studies indicate that diverse muscarinic receptor antagonists, acting via the M1 sub-type, promote neuritogenesis from sensory neurons in vitro and prevent and/or reverse both structural and functional indices of neuropathy in rodent models of diabetes. We sought to translate this as a potential therapeutic approach against structural and functional indices of diabetic neuropathy using oxybutynin, a muscarinic antagonist approved for clinical use against overactive bladder. Studies were performed using sensory neurons maintained in vitro, rodent models of type 1 or type 2 diabetes and human subjects with type 2 diabetes and confirmed neuropathy...
March 25, 2024: Acta Neuropathologica
https://read.qxmd.com/read/38526290/optimal-transcorneal-electrical-stimulation-parameters-for-preserving-photoreceptors-in-a-mouse-model-of-retinitis-pigmentosa
#33
JOURNAL ARTICLE
Sam Enayati, Karen Chang, Anton Lennikov, Menglu Yang, Cherin Lee, Ajay Ashok, Farris Elzaridi, Christina Yen, Kasim Gunes, Jia Xie, Kin-Sang Cho, Tor Paaske Utheim, Dong Feng Chen
JOURNAL/nrgr/04.03/01300535-202419110-00034/figure1/v/2024-03-08T184507Z/r/image-tiff Retinitis pigmentosa is a hereditary retinal disease that affects rod and cone photoreceptors, leading to progressive photoreceptor loss. Previous research supports the beneficial effect of electrical stimulation on photoreceptor survival. This study aims to identify the most effective electrical stimulation parameters and functional advantages of transcorneal electrical stimulation (tcES) in mice affected by inherited retinal degeneration...
November 1, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38525537/substance-p-promotes-tgf-%C3%AE-induced-collagen-synthesis-in-human-corneal-fibroblasts
#34
JOURNAL ARTICLE
Koji Sugioka, Teruo Nishida, Junko Murakami, Motoki Itahashi, Mai Yunoki, Shunji Kusaka
Corneal fibroblasts maintain homeostasis of the corneal stroma by mediating the synthesis and degradation of extracellular collagen, and these actions are promoted by transforming growth factor-β (TGF-β) and interleukin-1b (IL-1β), respectively. The cornea is densely innervated with sensory nerve fibers that are not only responsible for sensation but also required for physiological processes such as tear secretion and wound healing. Loss or dysfunction of corneal nerves thus impairs corneal epithelial wound healing and can lead to neurotrophic keratopathy...
March 25, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38524338/sodium-fluorescein-dye-as-an-adjunct-in-vitrectomy-for-rhegmatogenous-retinal-detachment-in-oculocutaneous-albinism
#35
Nitin Kumar, Krinjeela Bazgain, Simar Rajan Singh, Deeksha Katoch
A 48-year-old male with oculocutaneous albinism (OCA) presented with bilateral diminution of vision. Ocular examination revealed bilateral central corneal thinning, scarring with ectasia, depigmented irides, transillumination defects, and pseudophakia. Examination of the right eye also revealed a hyperoleon, emulsified silicon oil in the vitreous cavity, and an attached retina, while the left eye had a total rhegmatogenous retinal detachment (RRD). This case describes a unique set of challenges (the presence of an ectatic scarred cornea and a hypopigmented fundus) and sodium fluorescein dye as an adjunct in the surgical management of a complex RRD...
2024: Oman Journal of Ophthalmology
https://read.qxmd.com/read/38524336/manifestations-of-coronavirus-infection-disease-19-in-anterior-eye-segment-an-up-to-date-review
#36
REVIEW
Basheer Abdullah Marzoog
Coronavirus infection disease-19 (COVID-19) is a worldwide catastrophic emergency that first appeared in late 2019, in Wuhan, China. COVID-19 is a multitropism disease that first affects lung tissue. However, extrapulmonary manifestations have been suspected from the first COVID-19 cases. The ocular signs and symptoms were from the early changes that occur during the course of the disease. Changes in the anterior eye segment have a relatively higher incidence than the posterior eye segment. Of which, conjunctivitis, COVID-19 pharyngioceratoconjuctivitis, iridocyclitis, corneal punctate epitheliopathy, and pathomorphological changes in the physio-anatomy of the anterior eye segment...
2024: Oman Journal of Ophthalmology
https://read.qxmd.com/read/38524330/nummular-keratitis-a-rare-manifestation-of-brimonidine-allergy
#37
Maitha Al Asmi, Aisha Al Busaidi
A 32-year-old male, with juvenile open-angle glaucoma on chronic antiglaucoma therapy and recently introduced brimonidine eye drops to the treatment regimen, developed bilateral follicular conjunctivitis with subepithelial infiltrates (SEIs) initially resembling common infectious keratoconjunctivitis entities. The persistent nature of the conjunctivitis, the lack of positive conjunctival cultures, the absence of systemic symptoms, the full resolution of the condition upon discontinuation of antiglaucoma drops, and the commencement of topical steroids, along with the reappearance of SEIs upon reintroducing brimonidine; suggested an immune-mediated drug reaction secondary to a Benzalkonium chloride (BAK) preserved brimonidine tartrate 0...
2024: Oman Journal of Ophthalmology
https://read.qxmd.com/read/38524318/craters-on-the-cornea
#38
JOURNAL ARTICLE
Sujatha Mohan, Revathi Nambiar, Madhuvanthi Mohan, Sashwanthi Mohan
No abstract text is available yet for this article.
2024: Oman Journal of Ophthalmology
https://read.qxmd.com/read/38522059/applications-of-topical-immunomodulators-enhance-clinical-signs-of-vernal-keratoconjunctivitis-vkc-and-atopic-keratoconjunctivitis-akc-a-meta-analysis
#39
REVIEW
Nir Erdinest, Dror Ben Ephraim Noyman, Naomi London, Itay Lavy, Nadav Levinger, David Landau, Abraham Solomon, Yair Morad, Shehzad A Naroo
PURPOSE: This meta-analysis aimed to review the safety and efficacy of topical cyclosporine A (CsA) and topical tacrolimus in allergic eye disease. METHODS: A systematic search identified thirteen studies and a total of 445 patients for inclusion, making this the largest meta-analysis published on the subject. The current review was performed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). RESULTS: Thirteen randomized control trials were included in the meta-analysis...
March 24, 2024: International Ophthalmology
https://read.qxmd.com/read/38521828/balanced-activation-of-nrf-2-are-mediates-the-protective-effect-of-sulforaphane-on-keratoconus-in-the-cell-mechanical-microenvironment
#40
JOURNAL ARTICLE
Ruixing Liu, Ruojun Ma, Xiaoming Yan
Keratoconus (KC) is a progressive degenerative disease that usually occurs bilaterally and is characterized by corneal thinning and apical protrusion of the cornea. Oxidative stress is an indicator of the accumulation of reactive oxygen species (ROS), and KC keratocytes exhibit increased ROS production compared with that of normal keratocytes. Therefore, oxidative stress in KC keratocytes may play a major role in the development and progression of KC. Here, we investigated the protective effect of sulforaphane (SF) antioxidants using a hydrogel-simulated model of the cell mechanical microenvironment of KC...
March 23, 2024: Scientific Reports
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