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https://www.readbyqxmd.com/read/29223239/phacoemulsification-with-intraocular-lens-implantation-after-previous-descemetorhexis-without-endothelial-keratoplasty
#1
Aaron R Kaufman, Ricardo M Nosé, Yifan Lu, Roberto Pineda
A 58-year-old woman with bilateral Fuchs endothelial corneal dystrophy presented with predominantly central guttata in the left eye causing visually significant stromal edema. A 4.0 mm descemetorhexis without endothelial keratoplasty was performed. At the 6-week follow-up, the central cornea had cleared completely and the central endothelial cell density (ECD) was 541 cells/mm2. The central corneal clearing remained stable for 2 years after the procedure; however, vision declined because of a visually significant cataract in the left eye...
November 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29223236/mechanical-outcome-of-accelerated-corneal-crosslinking-evaluated-by%C3%A2-brillouin%C3%A2-microscopy
#2
Joshua N Webb, Johnny P Su, Giuliano Scarcelli
PURPOSE: To quantify corneal mechanical changes induced by corneal crosslinking (CXL) procedures of different ultraviolet-A (UVA) intensity and exposure time using Brillouin microscopy. SETTINGS: University of Maryland, College Park, Maryland, USA. DESIGN: Experimental study. METHODS: Porcine cornea samples were debrided of epithelia and soaked with riboflavin 0.1% solution. Samples were exposed to a standard 5.4 J/cm2 of UVA radiation with varying intensity and exposure time as follows: 3 mW/cm2 for 30...
November 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29223224/combined-interface-tattooing-and-fibrin-glue-assisted-sutureless-corneal-resurfacing-with-donor-lenticule-obtained-from-small-incision-lenticule-extraction-for-limbal-dermoid
#3
Soosan Jacob, Smita Narasimhan, Amar Agarwal, Athiya Agarwal, Saijimol Ai
We describe a technique of small-incision lenticule extraction (SMILE)-assisted sutureless corneal resurfacing with interface tattooing for superficial limbal dermoids. After excision at a plane minimally below surrounding normal cornea and sclera, a corneal tattoo powder is carefully applied within an inked circular outline of the intended corneal margin. Circularity and cosmesis are assessed in natural light with the microscope light off. Fibrin glue-assisted corneal resurfacing is performed with the lenticule...
November 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29221710/acanthamoeba-keratitis-in-patients-wearing-scleral-contact-lenses
#4
Matheus Porto Sticca, Linda C Carrijo-Carvalho, Isa M B Silva, Luiz A Vieira, Luciene B Souza, Rubens Belfort Junior, Fábio Ramos S Carvalho, Denise Freitas
PURPOSE: To report a series of cases of Acanthamoeba keratitis (AK) in scleral lens wearers with keratoconus to determine whether this type of contact lens presents a greater risk for development of infection. METHODS: This study reports three patients who wore scleral contact lenses to correct keratoconus and developed AK. The diagnoses of AK were established based on cultures of the cornea, scleral contact lenses, and contact lens paraphernalia. This study investigated the risk factors for infections...
December 5, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29218212/heads-up-descemet-membrane-endothelial-keratoplasty-performed-using-a-3d-visualization-system
#5
Virgilio Galvis, Ruben D Berrospi, Juan D Arias, Alejandro Tello, Julio C Bernal
A 68-year-old female underwent Descemet membrane endothelial keratoplasty (DMEK) in her right eye using a 3D visualization system with the surgeon looking directly to a digital screen instead of through the eyepieces of the surgical microscope. The procedure was uneventful. Five weeks after the surgery the DMEK graft was in good position and totally adhered, the cornea clear and uncorrected distance visual acuity 20/50. This is the first reported case of DMEK using 3D augmented reality visualization system...
November 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29217945/a-3-year-review-of-the-outcome-of-pars-plana-vitrectomy-for-dropped-lens-fragments-after-cataract-surgery-in-a-tertiary-eye-hospital-in-dhaka-bangladesh
#6
Lateefat Olokoba, Tajul Islam, Nazmun Nahar, Abdulraheem Mahmoud, Abdulfatai Olokoba
Background: Dropped lens fragments into the vitreous are uncommon, but potentially sight threatening complications of cataract surgery. The recommended approach for removal of dropped lens matter is pars plana vitrectomy with or without ultrasonic emulsification with the fragmatome. This study aimed to determine the visual outcome following pars plana vitrectomy for dropped lens fragments complicating cataract surgery at 6 weeks, 3 months and 6 months. Methods: This study is a retrospective review of patients who had PPV as treatment for dropped lens fragments complicating cataract surgery at Ispahani Islamia Eye hospital and Institute...
July 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29217475/in-vitro-drug-release-and-in-vivo-safety-of-vitamin-e-and-cysteamine-loaded-contact-lenses
#7
Phillip Dixon, Richard C Fentzke, Arnab Bhattacharya, Aditya Konar, Sarbani Hazra, Anuj Chauhan
Cystinosis is an orphan disease caused by a genetic mutation that leads to deposition of cystine crystals in many organs including cornea. Ophthalmic manifestation of the disease can be treated with hourly instillation of cysteamine eye drops. The hourly eye drop instillation is tedious to the patients leading to poor compliance and additionally, significant degradation of the drug occurs within one week of opening the bottle, which further complicates this delivery approach. This paper focuses on designing a contact lens to treat the disease with improved efficacy compared to eye drops, and also exploring safety of the drug eluding contact lens in an animal model...
December 4, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29217022/focal-limbal-stem-cell-deficiency-associated-with-soft-contact-lens-wear
#8
Karolien Termote, Steven Schendel, Gregory Moloney, Simon P Holland, Alex P Lange
OBJECTIVE: The aim of this study is to summarize the clinical characteristics of patients with contact lens-associated focal limbal stem cell deficiency (FLSCD) from a tertiary corneal referral centre. DESIGN: Retrospective, observational case series in a tertiary care centre. METHODS: Patients with contact lens-associated FLCSD were identified in our database. Clinical data were retrieved by chart review. A questionnaire asking for contact lens brand, type, cleaning solution, and duration of contact lens wear was sent to the patients with telephone follow-up...
December 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29216872/late-onset-diffuse-lamellar-keratitis-4%C3%A2-years-after-femtosecond-laser-assisted-small-incision-lenticule-extraction-a-case-report
#9
Meiyan Li, Dong Yang, Yingjun Chen, Meng Li, Tian Han, Xingtao Zhou, Katherine Ni
BACKGROUND: To report a first case of late-onset diffuse lamellar keratitis (DLK) occurring 4 years after femtosecond laser-assisted small incision lenticule extraction (SMILE). CASE PRESENTATION: A 41-year-old man who underwent SMILE 4 years prior developed DLK in the right eye 1 day after he was struck in the eye by a finger while playing with his son. Slim-lamp microscopy and anterior segment optical coherence tomography (AS-OCT) were used to evaluate the cornea of the right eye...
December 8, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29216189/new-intraocular-pressure-measurement-method-using-reflected-pneumatic-pressure-from-cornea-deformed-by-air-puff-of-ring-type-nozzle
#10
Hyung Jin Kim, Yeong Ho Seo, Byeong Hee Kim
In this study, a non-contact type intraocular pressure (IOP) measuring system using reflected pneumatic pressure is proposed to overcome the disadvantages of existing measurement systems. A ring-type nozzle, a key component in the proposed system, is designed via computational fluid analysis. It predicts the reflected pneumatic pressure based on the nozzle exit angle and inner and outer diameters of the nozzle, which are 30°, 7 mm, and 9 mm, respectively. Performance evaluation is conducted using artificial eyes fabricated using polydimethylsiloxane with the specifications of human eyes...
2017: PloS One
https://www.readbyqxmd.com/read/29215951/regulation-of-aqueous-humor-dynamics-by-hydrogen-sulfide-potential-role-in-glaucoma-pharmacotherapy
#11
Sunny E Ohia, Jenaye Robinson, Leah Mitchell, Kalu K Ngele, Segewkal Heruye, Catherine A Opere, Ya Fatou Njie-Mbye
Hydrogen sulfide (H2S) is a gaseous transmitter with well-known biological actions in a wide variety of tissues and organs. The potential involvement of this gas in physiological and pathological processes in the eye has led to several in vitro, ex vivo, and in vivo studies to understand its pharmacological role in some mammalian species. Evidence from literature demonstrates that 4 enzymes responsible for the biosynthesis of this gas (cystathionine β-synthase, CBS; cystathionine γ-lyase, CSE; 3-mercaptopyruvate sulfurtransferase, 3MST; and d-amino acid oxidase) are present in the cornea, iris, ciliary body, lens, and retina...
December 7, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29215396/outcomes-of-corneal-cross-linking-correlate-with-cone-specific-lysyl-oxidase-expression-in-patients-with-keratoconus
#12
Rohit Shetty, Nimisha Rajiv Kumar, Natasha Pahuja, Rashmi Deshmukh, KrishnaPoojita Vunnava, Valsala Gopalakrishnan Abilash, Abhijit Sinha Roy, Arkasubhra Ghosh
PURPOSE: To evaluate the correlation of visual and keratometry outcomes after corneal cross-linking (CXL) in patients with keratoconus with cone epithelium-specific gene expression levels. METHODS: Corneal epithelium was obtained from 35 eyes that underwent accelerated CXL (KXLII, 9 mW/cm for 10 min). Using corneal topography, epithelium over the cone and periphery was obtained separately from each subject. The ratio of gene expression for lysyl oxidase (LOX), matrix metalloproteinase 9 (MMP9), bone morphogenic protein 7, tissue inhibitor of metalloproteinase 1, collagen, type I, alpha 1, and collagen, type IV, alpha 1 (COL IVA1) from the cone and peripheral cornea was correlated with the outcome of cross-linking surgery...
December 5, 2017: Cornea
https://www.readbyqxmd.com/read/29214074/tilt-decentration-and-internal-higher-order-aberrations-of-sutured-posterior-chamber-intraocular-lenses-in-patients-with-open-globe-injuries
#13
Xiangjia Zhu, Yinglei Zhang, Wenwen He, Hongfei Ye, Chunhui Jiang, Yi Lu
Purpose: To evaluate the tilt, decentration, and internal higher-order aberrations (HOAs) of sutured posterior-chamber intraocular lenses (IOLs) in patients with open globe injuries. Methods: 46 consecutive patients (47 eyes) who underwent transsclerally sutured IOL implantation were enrolled in this prospective cohort study. Nineteen eyes had a history of open globe injury. The tilt and decentration of the IOLs and the visual quality were measured 1 month after surgery...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29213190/smartphone-based-imaging-of-the-corneal-endothelium-at-sub-cellular-resolution
#14
Devrim Toslak, Damber Thapa, Muhammet Kazim Erol, Yanjun Chen, Xincheng Yao
This aim of this study was to test the feasibility of smartphone-based specular microscopy of the corneal endothelium at a sub-cellular resolution. Quantitative examination of endothelial cells is essential for evaluating corneal disease such as determining a diagnosis, monitoring progression and assessing treatment. Smartphone-based technology promises a new opportunity to develop affordable devices to foster quantitative examination of endothelial cells in rural and underserved areas. In our study, we incorporated an iPhone 6 and a slit lamp to demonstrate the feasibility of smartphone-based microscopy of the corneal endothelium at a sub-cellular resolution...
2017: Journal of Modern Optics
https://www.readbyqxmd.com/read/29212712/a-reversible-thermoresponsive-sealant-for-temporary-closure-of-ocular-trauma
#15
Niki Bayat, Yi Zhang, Paulo Falabella, Roby Menefee, John J Whalen, Mark S Humayun, Mark E Thompson
Open globe injuries are full-thickness injuries sustained to the eye wall (cornea or sclera), which cause immediate drops in intraocular pressure that may lead to retinal detachment and permanent vision loss if not treated rapidly after injury. The current standard of care for open globe injuries consists of suturing the margins closed, but the technique can be time-consuming, requires specialized training and equipment, and can lead to patient discomfort, abrasion, and infection from eye rubbing. We engineered an injectable, thermoresponsive sealant (TRS) and a custom tool to occlude open globe injuries...
December 6, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/29210827/demarcation-line-in-the-human-cornea-after-surface-ablation-observed-by-optical-coherence-tomography-and-confocal-microscopy
#16
Meiyan Li, Yu Zhao, Qirui Xiao, Peijun Yao, Mingzi Piao, Ling Sun, Xingtao Zhou
PURPOSE: To investigate the long-term changes in anterior corneal structure after surface ablation. METHODS: In this retrospective study, patients who received surface ablation including laser-assisted subepithelial keratomileusis (LASEK) and epipolis laser in situ keratomileusis at the Department of Ophthalmology of Fudan University Eye and Ear, Nose and Throat (EENT) Hospital (Shanghai, People's Republic of China) were telephoned. Patients were asked to follow-up at the refractive center...
November 28, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/29208829/comparative-analysis-of-endothelial-cell-loss-following-phacoemulsification-in-pupils-of-different-sizes
#17
Rakesh Maggon, Raghudev Bhattacharjee, Sandeep Shankar, Rajesh Chandra Kar, Vivek Sharma, Shyamal Roy
PURPOSE: To compare Endothelial cell(EC) loss following Phacoemulsification (PKE) in pupils of different sizes. METHODS: A prospective double masked observational study in which a total of 150 eyes of 150 patients between 50 & 70 years of age with senile cataract of nuclear sclerosis grade II were enrolled. Patients were allocated into three groups of 50 eyes each in Group A (pupil size <5 mm), Group B (pupil size 5-7 mm) and Group C (pupil size >7 mm). Pupillary size was measured by determining the height of slit on slit-lamp biomicroscope examination...
December 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29208552/controlling-human-corneal-stromal-stem-cell-contraction-to-mediate-rapid-cell-and-matrix-organization-of-real-architecture-for-3-dimensional-tissue-equivalents
#18
Dev Mukhey, James Phillips, Julie T Daniels, Alvena K Kureshi
The architecture of the human corneal stroma consists of a highly organized extracellular matrix (ECM) interspersed with keratocytes. Their progenitor cells; corneal stromal stem cells (CSSC) are located at the periphery, in the limbal stroma. A highly organized corneal ECM is critical for effective transmission of light but this structure may be compromised during injury or disease, resulting in loss of vision. Re-creating normal organization in engineered tissue equivalents for transplantation often involves lengthy culture times that are inappropriate for clinical use or utilisation of synthetic substrates that bring complications such as corneal melting...
December 2, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29207710/a-case-of-keratomycosis-caused-by-fusarium-solani-at-rural-tertiary-care-center
#19
Vishal Laxmikant Kulkarni, Anagha Govind Kinikar, Deepika Shivaji Bhalerao, S Roushani
Keratomycosis is defined as invasive infection of corneal stroma caused by variety of fungi. Most of these cases occur in agricultural workers with history of corneal trauma with vegetative matter contaminated by fungi. Fusarium species which causes keratomycosis receives occasional mention in literature. We report a case of a 27-year-old male, farmer by occupation presented with complains of foreign body sensation, itching and discharge from the right eye and developed white patch on cornea which was progressed gradually to size of diameter of pea which was later diagnosed as keratitis caused by Fusarium species...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207049/coordinated-microrna-mrna-expression-profiles-reveal-a-putative-mechanism-of-corneal-epithelial-cell-transdifferentiation-from-skin-epidermal-stem-cells
#20
Yanjie Guo, Xiya Ma, Weini Wu, Mingyan Shi, Junlong Ma, Yaping Zhang, Erkang Zhao, Xueyi Yang
Skin epidermal stem cells (SESCs), which share a single origin with corneal epithelial cells (CECs), are considered to be one of the most ideal seed cells for the construction of tissue engineered corneas. However, the mechanism underlying the transdifferentiation of SESCs to CECs has not been fully elucidated. In the present study, to identify critical microRNAs (miRNAs/miRs) and genes that regulate the transdifferentiation of SESCs to CECs, SESCs and CECs were collected from sheep and used for small RNA sequencing and mRNA microarray analyses...
December 1, 2017: International Journal of Molecular Medicine
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