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https://www.readbyqxmd.com/read/29684677/human-stem-cell-based-corneal-tissue-mimicking-structures-using-laser-assisted-3d-bioprinting-and-functional-bioinks
#1
Anni Sorkio, Lothar Koch, Laura Koivusalo, Andrea Deiwick, Susanna Miettinen, Boris Chichkov, Heli Skottman
There is a high demand for developing methods to produce more native-like 3D corneal structures. In the present study, we produced 3D cornea-mimicking tissues using human stem cells and laser-assisted bioprinting (LaBP). Human embryonic stem cell derived limbal epithelial stem cells (hESC-LESC) were used as a cell source for printing epithelium-mimicking structures, whereas human adipose tissue derived stem cells (hASCs) were used for constructing layered stroma-mimicking structures. The development and optimization of functional bioinks was a crucial step towards successful bioprinting of 3D corneal structures...
April 16, 2018: Biomaterials
https://www.readbyqxmd.com/read/29683519/children-with-mucopolysaccharidosis-risk-progressive-visual-dysfunction-despite-haematopoietic-stem-cell-transplants
#2
Kristina Teär Fahnehjelm, Monica Olsson, Enping Chen, Jürg Hengstler, Karin Naess, Jacek Winiarski
AIM: This prospective study assessed the long-term ocular and visual outcomes of children with mucopolysaccharidoses type I Hurler syndrome (MPS IH) who were treated with haematopoietic stem cell transplants (HSCT). METHODS: Clinical ophthalmological assessments were performed on eight patients at the St Erik Eye Hospital, Stockholm, Sweden, from 2001-2018: The median age at diagnosis and HSCT were 12.2 (range 5.0-16.4) and 16.7 (8.0-20.4) months. The last eye examination was at a median of 13...
April 23, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29682341/corneal-subbasal-nerve-recovery-in-an-acute-case-of-ultraviolet-keratitis-treated-with-autologous-serum-eye-drops
#3
Farshad Abedi, Pedram Hamrah
Purpose: To report degeneration of subbasal corneal nerves and the subsequent neuroregeneration in a case of acute ultraviolet (UV) keratitis, treated with autologous serum eye drops. Methods: Case report. Results: A 37-year-old female presented with ocular discomfort and blurred vision in both eyes, after exposure to UV-C light in a laboratory. On exam, she had bilateral conjunctival injection and superficial punctate keratitis (SPK), worse in the left, consistent with acute, bilateral, but asymmetric UV-C keratitis...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29681843/wheel-spokes-technique-for-endothelial-keratoplasty-for-extremely-mydriatic-bullous-keratopathy-eyes-without-capsular-support
#4
Hidenori Tanaka, Koji Hirano, Masayuki Horiguchi
We describe a new technique to prevent an endothelial donor graft from dropping into the vitreous cavity during non-Descemet stripping automated endothelial keratoplasty (nDSAEK) for extremely mydriatic bullous keratopathy (BK) eyes without capsular support. The patient was a 79-year-old woman who underwent nDSAEK for an extremely mydriatic BK eye with an incomplete barrier between the anterior and posterior chambers. She had undergone argon laser iridotomy for acute glaucoma at the age of 59 years and cataract surgery 3 years later...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29681834/amnwiotic-membrane-transplantation-as-a-treatment-for-sterile-infiltration-and-corneal-melting-after-corneal-crosslinking-for-keratoconus
#5
Takanori Sasaki, Takeshi Ide, Ikuko Toda, Naoko Kato
We report a case of corneal melting through sterile infiltration presumably due to excessive use of nonsteroidal anti-inflammatory eye drops after corneal crosslinking (CXL). It was treated using steroids combined with amniotic membrane transplantation (AMT). A 33-year-old man with progressing keratoconus underwent left eye CXL. We prescribed betamethasone and levofloxacin eye drops 5 times daily and diclofenac sodium eye drops 3 times daily for 3 days. Three days after CXL, there was a persistent epithelial defect and the left corneal stroma was clouded...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29681725/the-effects-of-bevacizumab-treatment-in-a-rat-model-of-retinal-ischemia-and-perfusion-injury
#6
Maryo Cenk Kohen, Sinan Tatlipinar, Alev Cumbul, Ünal Uslu
Purpose: To create a model of an ischemic retina with temporary ischemia and reperfusion (IR) and to examine the possible antiapoptotic and neurodegenerative effects of a vascular endothelial growth factor (VEGF) antagonist. Methods: Three groups were formed. Rats were subjected to continued ischemia for 45 min, and then reperfusion was allowed for 2 days. For the first group, ischemia was induced, but an anti-VEGF agent was not administered. For the second group, 2 days before ischemia, 0...
2018: Molecular Vision
https://www.readbyqxmd.com/read/29681179/-femtosecond-laser-assisted-keratoplasty
#7
László Módis, Eszter Szalai, Zsuzsanna Flaskó, Bence Kolozsvári, András Berta
INTRODUCTION AND AIM: To present our results on femtosecond laser-assisted penetrating keratoplasty. PATIENTS AND METHOD: Twenty-five eyes of 25 patients underwent surgery with the following indications: pseudophakic bullous keratopathy (n = 10), keratoconus (n = 4), corneal dystrophy (n = 5), corneal scar (n = 4), band keratopathy (n = 2). Trephination of both the donor and recipient corneas were performed with VisuMax femtosecond laser device (Carl Zeiss Meditec AG, Jena, Germany)...
April 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29677103/ocular-delivery-system-for-propranolol-hydrochloride-based-on-nanostructured-lipid-carrier
#8
Behzad Sharif Makhmal Zadeh, Hassan Niro, Fakher Rahim, Golbarg Esfahani
One drawback of traditional forms of medical ocular dosage is drug dilution by tear; moreover, drugs are rapidly drained away from pre-corneal cavity by tear flow and lacrimo-nasal drainage. Prolonging contact time with different strategies and mucoadhesive vehicles will help to continuously deliver drugs to the eyes. For this study, we prepared and evaluated the effects of a nanostructure lipid carrier (NLC) on propranolol hydrochloride as a hydrophilic drug model for rabbit corneal permeation. Propranolol hydrochloride NLC was prepared using cold homogenization...
April 20, 2018: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/29677004/new-surgical-modality-for-management-of-corneal-perforation-using-bowman-membrane
#9
Dharamveer Singh Choudhary, Nikhil Agrawal
PURPOSE: To describe a new surgical modality, "Bowman membrane tuck-in," for management of small to medium sized corneal perforation of a noninfectious etiology. METHODS: Two patients with corneal perforation of a noninfectious etiology and less than 4 mm in size underwent Bowman membrane tuck-in, a new surgical procedure. In this technique, Bowman membrane harvested from the donor cornea was tucked inside the stromal pocket of host tissue, which was prepared by 360-degree anterior stromal lamellar dissection...
April 19, 2018: Cornea
https://www.readbyqxmd.com/read/29676320/unveiling-opacification-of-intraocular-lens-following-a-successful-penetrating-keratoplasty-for-extensively-scarred-cornea-due-to-microbial-keratitis-after-descemet-s-stripping-automated-endothelial-keratoplasty
#10
https://www.readbyqxmd.com/read/29675394/cryopreserved-limbal-lamellar-keratoplasty-for-peripheral-corneal-and-limbal-reconstruction
#11
Hua-Tao Xie, Jing Li, Yang Liu, Dong-Ling Jiang, Rui-Fen Shen, Ming-Chang Zhang
This study aimed to evaluate the outcomes and described the recovery process of cryopreserved limbal lamellar keratoplasty (CLLK) for peripheral corneal and limbal diseases. Thirteen eyes of 12 patients with a mean age of 41±23.9y were included. The average follow-up was 12.1±5.6mo. Stable ocular surface was achieved in all eyes at last follow-up. Epithelialization originated from both recipient and graft in 9 eyes. We conclude that CLLK compensates for the shortage of donor corneas and cryopreserved limbal grafts provide epithelialization sources in ocular surface reconstruction...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29675392/efficacy-of-iontophoresis-assisted-epithelium-on-corneal-cross-linking-for-keratoconus
#12
REVIEW
Hong-Zhen Jia, Xiu-Jun Peng
Corneal cross-linking (CXL) is a noninvasive therapeutic procedure for keratoconus that is aimed at improving corneal biomechanical properties by induction of covalent cross-links between stromal proteins. It is accomplished by ultraviolet A (UVA) radiation of the cornea, which is first saturated with photosensitizing riboflavin. It has been shown that standard epithelium-off CXL (S-CXL) is efficacious, and it has been recommended as the standard of care procedure for keratoconus. However, epithelial removal leads to pain, transient vision loss, and a higher risk of corneal infection...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29675388/consistent-comparison-of-angle-kappa-adjustment-between-oculyzer-and-topolyzer-vario-topography-guided-lasik-for-myopia-by-ex500-excimer-laser
#13
Ming-Shen Sun, Li Zhang, Ning Guo, Yan-Zheng Song, Feng-Ju Zhang
AIM: To evaluate and compare the uniformity of angle Kappa adjustment between Oculyzer and Topolyzer Vario topography guided ablation of laser in situ keratomileusis (LASIK) by EX500 excimer laser for myopia. METHODS: Totally 145 cases (290 consecutive eyes )with myopia received LASIK with a target of emmetropia. The ablation for 86 cases (172 eyes) was guided manually based on Oculyzer topography (study group), while the ablation for 59 cases (118 eyes) was guided automatically by Topolyzer Vario topography (control group)...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29675369/boxb-mediate-balb-c-mice-corneal-inflammation-through-a-tlr4-myd88-dependent-signaling-pathway-in-aspergillus-fumigatus-keratitis
#14
Min Liu, Cui Li, Gui-Qiu Zhao, Jing Lin, Cheng-Ye Che, Qiang Xu, Qian Wang, Rui Xu, Ya-Wen Niu
AIM: To investigate whether high-mobility group box 1 (HMGB1) Boxb exacerbates BALB/c mice corneal immune responses and inflammatory through the Toll-like receptor 4 (TLR4)/myeloid differentiation primary response 88 (MyD88)-dependent signaling pathway in Aspergillus fumigatus ( A. fumigatus ) keratitis. METHODS: The mice corneas were pretreated with phosphate buffer saline (PBS), Boxb before A. fumigatus infection. The abdominal cavity extracted macrophages were pretreated with PBS, Boxb, TLR4 inhibitor (CLI-095), Dimethyl sulfoxide (DMSO) separately before A...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29675368/mincle-in-the-innate-immune-response-of-mice-fungal-keratitis
#15
Guo-Rong Yu, Jing Lin, Jie Zhang, Cheng-Ye Che, Xu-Dong Peng, Cui Li, Li-Ting Hu, Guo-Qiang Zhu, Kun He, Gui-Qiu Zhao
AIM: To investigate how macrophage inducible C-type lectin (Mincle) influences inflammation in mice fungal keratitis induced by Aspergillus fumigatus ( A. fumigatus ). METHODS: C57BL/6 mice were infected with A. fumigatus after pretreated with Mincle agonist TDB or Mincle neutralizing antibody (MincleAb), taking DMSO or IgG as control group respectively. The cornea lesions were monitored with slit-lamp microscope and evaluated by clinical score. Mincle expression was assessed using reverse transcription-ploymerase chain reaction (RT-PCR) and immunostaining...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29674850/effect-of-dietary-oils-on-peripheral-neuropathy-related-endpoints-in-dietary-obese-rats
#16
Lawrence Coppey, Eric Davidson, Hanna Shevalye, Michael E Torres, Mark A Yorek
Purpose: This study aimed to determine the effect of dietary oils (olive, safflower, evening primrose, flaxseed, or menhaden) enriched in different mono unsaturated fatty acids or polyunsaturated fatty acids on peripheral neuropathies in diet-induced obese Sprague-Dawley rats. Materials and methods: Rats at 12 weeks of age were fed a high-fat diet (45% kcal) for 16 weeks. Afterward, the rats were fed diets with 50% of the kilocalories of fat derived from lard replaced by the different dietary oils...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/29672430/recovery-of-corneal-clarity-after-dmek-followed-by-rebubbling-versus-uneventful-dmek
#17
Apostolos Lazaridis, Ourania Fydanaki, Eleftherios Giallouros, Ilias Georgalas, George Kymionis, Walter Sekundo, Konstantinos Droutsas
PURPOSE: To evaluate the effect of a single rebubbling procedure after Descemet membrane endothelial keratoplasty (DMEK) on corneal backscatter and endothelial cell loss (ECL). METHODS: Medical records of 130 consecutive DMEK cases (118 patients) were reviewed and 3 groups were formed: group 1 (n = 32), consisting of DMEK cases followed by 1 rebubbling; group 2a (n = 55), including uneventful DMEK cases with complete graft attachment; and group 2b (n = 25), including uneventful DMEK cases with minor peripheral detachment, not requiring rebubbling...
April 19, 2018: Cornea
https://www.readbyqxmd.com/read/29672246/stromal-keratitis-with-endophthalmitis-caused-by-vittaforma-corneae-in-an-immunocompetent-patient-a-case-report
#18
Lalida Pariyakanok, Vannarut Satitpitakul, Prasart Laksanaphuk, Kitiya Ratanawongphaibul, Chaturong Putaporntip, Somchai Jongwutiwes
PURPOSE: To describe a case of microsporidial stromal keratitis with endophthalmitis in an immunocompetent patient. METHODS: Case reportResults: A 58-year-old HIV-negative man presented with stromal keratitis in his right eye. The patient demonstrated subsequent vitritis, multifocal retinitis and arteritis, and macular edema with recurrent vitreous hemorrhage after therapeutic keratoplasty. Numerous microsporidial spores were detected in corneal tissues by modified trichrome stain...
April 19, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29670830/improved-high-frequency-ultrasound-corneal-biometric-accuracy-by-micrometer-resolution-acoustic-property-maps-of-the-cornea
#19
Daniel Rohrbach, Ronald H Silverman, Dan Chun, Harriet O Lloyd, Raksha Urs, Jonathan Mamou
Purpose: Mapping of epithelial thickness (ET) is useful for detection of keratoconus, a disease characterized by corneal thinning and bulging in which epithelial thinning occurs over the apex. In prior clinical studies, optical coherence tomography (OCT) measurements of ET were systematically thinner than those obtained by 40-MHz high-frequency ultrasound (HFU) where a constant speed of sound ( c ) of 1636 m/s was used for all corneal layers. The purpose of this work was to study the acoustic properties, that is, c , acoustic impedance ( Z ), and attenuation ( α ) of the corneal epithelium and stroma independently using a scanning acoustic microscope (SAM) to investigate the discrepancy between OCT and HFU estimates of ET...
April 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29669784/pd-l1-b7-h1-inhibits-viral-clearance-by-macrophages-in-hsv-1-infected-corneas
#20
Sohyun Jeon, Alexander M Rowe, Kate L Carroll, Stephen A K Harvey, Robert L Hendricks
Immune privilege helps protect the cornea from damaging inflammation but can also impair pathogen clearance from this mucosal surface. Programmed death-ligand 1 (PD-L1 or B7-H1) contributes to corneal immune privilege by inhibiting the function of a variety of immune cells. We asked whether programmed death-1 (PD-1)/PD-L1 interaction regulates HSV-1 clearance from infected corneas. We show that PD-L1 is constitutively expressed in the corneal epithelium and is upregulated upon HSV-1 corneal infection, with peak expression on CD45+ cells NK cells, dendritic cells, neutrophils, and macrophages and CD45- corneal epithelial cells at 4 d postinfection (dpi)...
April 18, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
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