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https://www.readbyqxmd.com/read/29471020/ezrin-as-a-complementary-marker-in-ocular-toxicity-assessment-using-a-three-dimensional-reconstructed-human-corneal-like-epithelium-model-epiocular%C3%A2
#1
Kyung Yuk Ko, MiHye Hong, Tae Sung Kim, Ki Taek Nam, GaYoung Lee, Jung-Sun Yi, Il Young Ahn, Joo Hwan Kim, Jong Kwon Lee
INTRODUCTION: A variety of in vitro tests to replace the Draize test have been developed; however, there is no available method for assessing the full spectrum of Globally Harmonized System (GHS) categories. Human cornea-like three-dimensional (3D) reconstructed tissue models are the most promising in vitro systems. The objective of this study was to evaluate the ocular toxicity of 11 test substances using the EpiOcular™ model after performing proficiency tests. We further evaluated the effectiveness of ezrin staining as a complementary marker in histological analysis to overcome the limitation of eye irritation tests using 3D reconstructed human corneal epithelium models...
February 19, 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29470971/use-of-autologous-serum-tears-for-the-treatment-of-ocular-surface-disease-from-patients-with-systemic-autoimmune-diseases
#2
Tayyeba K Ali, Allister Gibbons, Cristián Cartes, Siamak Zarei-Ghanavati, Mohamed Gomaa, Ingrid Gonzalez, Astrid E Gonzalez, Hilal E Ozturk, Carolina Betancurt, Victor L Perez
PURPOSE: To describe the safety and efficacy of autologous serum tears (AST) in managing ocular surface disease resistant to conventional therapy in patients with systemic autoimmune disease(s). DESIGN: Retrospective, interventional case series. METHODS: Records of patients from 2009 to 2015 with systemic autoimmune disease treated with AST (20-50%) for chronic surface disease were analyzed. Standardized measures of subjective dry eye symptoms, objective dry eye staining of the cornea, and slit lamp findings including punctate epithelial erosion (PEE), filamentary keratopathy (FK) and corneal epithelial defects (KED) were compared during first and last visit...
February 19, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29468296/-corneal-densitometry-value-for-keratoconus-diagnostics
#3
REVIEW
M Alnawaiseh, N Eter
BACKGROUND: Corneal densitometry, based on the Scheimpflug principle, is a useful noninvasive tool for quantitative evaluation of the optical quality of the cornea. It enables us to evaluate corneal transparency in the different corneal layers and different annuli. In this article, we discuss the basis of application of corneal densitometry measurements and summarize findings in patients with keratoconus. METHODS: This article is based on a selective literature review and analysis of own data...
February 21, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29468223/a-case-of-hypertrophic-herpes-simplex-virus-affecting-the-eyelid-and-cornea-masquerading-as-igg4-related-disease
#4
Prachi Dua, Roman Shinder, Derek B Laskar, Douglas R Lazzaro, Allison E Rizzuti
Purpose: To report a case of hypertrophic herpes simplex virus (HSV) of the eyelid and cornea masquerading as IgG4-related disease. Observations: A 37-year old African American female with a past medical history of human immunodeficiency virus (HIV) on highly active antiretroviral therapy (HAART) and a recent history of treated genital herpes, presented with an ulcerative lesion of the left upper and lower eyelids, and severe ocular inflammation with symblepharon...
March 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29467436/fabrication-of-transparent-hemispherical-3d-nanofibrous-scaffolds-with-radially-aligned-patterns-via-a-novel-electrospinning-method
#5
Jeong In Kim, Ju Yeon Kim, Chan Hee Park
Tissue engineering has significantly contributed to the development of optimal treatments for individual injury sites based on their unique functional and histologic properties. Human organs and tissue have three-dimensional (3D) morphologies; for example, the morphology of the eye is a spherical shape. However, most conventional electrospinning equipment is only capable of fabricating a two-dimensional (2D) structured fibrous scaffold and no report is available on a 3D electrospinning method to fabricate a hemispherical scaffold to mimic the native properties of the cornea, including microscopic to macroscopic morphology and transparency...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29465543/spontaneous-reattachment-of-descemet-membrane-detachment-after-deep-anterior-lamellar-keratoplasty-a-case-report
#6
Xiaolei Lin, Yue Wu, Yana Fu, Qi Dai
RATIONALE: To report a case of late spontaneous reattachment of Descemet membrane (DM) detachment after deep anterior lamellar keratoplasty (DALK). PATIENT CONCERNS: A 50-year-old woman with stromal corneal scarring underwent a DALK with the big bubble technique. The DM detachment and double anterior chamber were observed on the first day after operation. DIAGNOSES: Descemet membrane detachment after deep anterior lamellar keratoplasty [Oculus Dexter (OD), indicates right eye]...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29465315/ginsenoside-rh2-inhibits-vascular-endothelial-growth-factor-induced-corneal-neovascularization
#7
Xiao-Pei Zhang, Ke-Ran Li, Qing Yu, Mu-Di Yao, Hui-Min Ge, Xiu-Miao Li, Qin Jiang, Jin Yao, Cong Cao
VEGF-induced neovascularization plays a pivotal role in corneal neovascularization (CoNV). The current study investigated the potential effect of ginsenoside Rh2 (GRh2) on neovascularization. In HUVECs, pretreatment with GRh2 largely attenuated VEGF-induced cell proliferation, migration, and vessel-like tube formation in vitro. At the molecular level, GRh2 disrupted VEGF-induced VEGF receptor 2 (VEGFR2)-Grb-2-associated binder 1 (Gab1) association in HUVECs, causing inactivation of downstream AKT and ERK signaling...
February 20, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29465209/-mitochondria-targeted-antioxidants-in-the-prevention-of-the-cornea-erosion-when-performing-surgery-under-general-anesthesia
#8
E A Gusev, D V Chemodanov, V A Sungurov, E A Neverovsky, O A Grebenchikov, V V Likhvantsev
Despite the use of modern methods of prevention, at least 10% of patients operated on for ophthalmic indications not develop corneal erosion as the indirect complication of general anesthesia. OBJECTIVE: To reduce the number of ophthalmic complications of general anesthesia by prophylactic use of new mito- chondria-targeted antioxidants - Vizomitin (eye drops). MATERIALS AND METHODS: 70 patients, which was supposed to perform the average duration of operations under general anesthesia were randomized into 3 groups depending on the method specific (pharmacological) prevention of corneal erosions: (1) control (specic (pharmacological) prevention was not carried out), (2), using preparation "natural tear, and (3) "Vizomitin" preparation...
September 2017: Anesteziologiia i Reanimatologiia
https://www.readbyqxmd.com/read/29463199/airborne-particulate-matter-impairs-corneal-epithelial-cells-migration-via-disturbing-fak-rhoa-signaling-pathway-and-cytoskeleton-organization
#9
Yu-Hong Cui, Zi-Xuan Hu, Zi-Xun Gao, Xi-Ling Song, Qing-Yang Feng, Guang Yang, Zhi-Jie Li, Hong-Wei Pan
BACKGROUND: Cornea is the outmost structure of the eye and exposed directly to the air pollution. However, little is known about the effect of PM2.5 on corneal epithelium, which is critical for maintenance of cornea homeostasis and visual function. OBJECTIVE: We investigated the influence of PM2.5 exposure on corneal epithelial migration and the possible mechanisms involved in the process. METHODS: We observed wound healing in mouse model of cornea abrasion, evaluated the migration and mobility of cultured corneal epithelial cells with wound scratch assay and Transwell migration assay, detected the phosphorylation and interaction of FAK/paxillin with immunofluorescence and immunoprecipitation, and determined the RhoA activity and actin reorganization, in response to PM2...
February 20, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/29461005/clinical-findings-and-normative-ocular-data-for-free-living-anna-s-calypte-anna-and-black-chinned-archilochus-alexandri-hummingbirds
#10
Bret A Moore, David J Maggs, Soohyun Kim, Monica J Motta, Ruta Bandivadekar, Lisa A Tell, Christopher J Murphy
OBJECTIVE: To estimate the prevalence of ocular disease and obtain normative ocular data for free-living hummingbirds. ANIMALS STUDIED: Two hundred and sixty-three free-living, adult Hummingbirds from coastal and inland central California were studied, including Anna's (Calypte anna, n = 186) and Black-chinned (Archilochus alexandri; n = 77) hummingbirds. PROCEDURES: Slit lamp biomicroscopy and indirect ophthalmoscopy were performed on all individuals...
February 20, 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29459766/greater-corneal-nerve-loss-at-the-inferior-whorl-is-related-to-the-presence-of-diabetic-neuropathy-and-painful-diabetic-neuropathy
#11
Alise Kalteniece, Maryam Ferdousi, Ioannis Petropoulos, Shazli Azmi, Safwaan Adam, Hassan Fadavi, Andrew Marshall, Andrew J M Boulton, Nathan Efron, Catharina G Faber, Giuseppe Lauria, Handrean Soran, Rayaz A Malik
We assessed whether a measure of more distal corneal nerve fibre loss at the inferior whorl(IW) region is better than proximal measures of central corneal nerve damage in relation to the diagnosis of diabetic peripheral neuropathy(DPN), painful DPN and quality of life(QoL). Participants underwent detailed assessment of neuropathy, QoL using the SF36 questionnaire, pain visual analogue score(VAS), and corneal confocal microscopy(CCM). Corneal nerve fibre density (CNFD), branch density (CNBD) and length (CNFL) at the central cornea and inferior whorl length (IWL) and average(ANFL) and total(TNFL) nerve fibre length were compared in patients with and without DPN and between patients with and without painful DPN and in relation to QoL...
February 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29458290/neuregulin-1-accelerates-corneal-epithelial-wound-healing
#12
Won-Yong Jeong, Hye-Young Yoo, Chan-Wha Kim
Corneal epithelial cells (CECs) play an important role in the function of the cornea, and are maintained by corneal epithelial stem cells (CESCs). Recent studies have shown that neuronal growth factors affect the proliferation and migration of CESCs. Neuregulin-1 (NR-1) is a neuronal growth factor that is expressed in the early stages of brain development. The aim of this study was to determine whether NR-1 activates corneal wound healing. We observed that NR-1 activated both proliferation and migration of CECs...
February 20, 2018: Growth Factors
https://www.readbyqxmd.com/read/29458206/mucoadhesive-self-emulsifying-delivery-systems-for-ocular-administration-of-econazole
#13
Ibrahim A Elbahwy, Noemi Lupo, Hany M Ibrahim, Hatem R Ismael, Alaa A Kasem, Cagri Caliskan, Barbara Matuszczak, Andreas Bernkop-Schnürch
AIM: Development of mucoadhesive self-emulsifying drug delivery systems (SEDDS) providing a prolonged ocular residence time for poorly soluble active pharmaceutical ingredient. METHODS: L-Cysteine was covalently linked to 6-mercaptonicotinamide. The obtained ligand, Cysteine-6- mercaptonicotinamide (Cys-6-MNA) was attached to Eudragit® L100-55 via a carbodiimide mediated amide bond formation. The resulting entirely S-protected thiolated Eudragit® L100-55 was characterized regarding the degree of modification as well as stability toward oxidation in the presence of strong oxidizing agent (H2 O2 )...
February 16, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29453060/effect-of-selenium-on-penaeus-monodon-and-perna-viridis-enzyme-activities-and-histopathological-responses
#14
Avula Nagarjuna, Panneerselvam Karthikeyan, Dhandapani Mohan, Shambanagouda Rudragouda Marigoudar
The study was carried out to evaluate enzyme activities and histopathological changes due to the effect of acute and chronic definitive toxicity of selenium (Se) on the post larvae (PL) of giant tiger shrimp (Penaeus monodon), and green mussel (Perna viridis). The 96-h Median Lethal concentration (LC 50 ) for the PL of shrimp was 3.36 mg L -1 and the chronic value for the long-term survival endpoint in a 21-d exposure was 0.10 mg L -1 . The green mussel 96-h LC 50 was 28.41 mg L -1 and the chronic value for the long-term survival endpoint in a 30-d exposure was 3...
February 10, 2018: Chemosphere
https://www.readbyqxmd.com/read/29452886/shifting-the-igf-axis-an-age-related-decline-in-human-tear-igf-1-correlates-with-clinical-signs-of-dry-eye
#15
Roshni Patel, Meifang Zhu, Danielle M Robertson
OBJECTIVE: The human corneal epithelium expresses both the insulin-like growth factor type 1 receptor (IGF-1R) and the IGF-1R/insulin receptor (INSR) hybrid. Despite the previous identification of IGF-1 in human tear fluid, little is known regarding the regulation of IGF-1 in tear fluid and its role in corneal epithelial homeostasis. In the present study, we investigated the impact of biological parameters on the concentration of human tear levels of IGF-1. DESIGN: Tear levels of IGF-1 were measured in 41 healthy, human volunteers without any reported symptoms of dry eye...
February 6, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29451741/non-invasive-optical-method-for-real-time-assessment-of-intracorneal-riboflavin-concentration-and-efficacy-of-corneal-cross-linking
#16
Giuseppe Lombardo, Valentina Villari, Norberto Liborio Micali, Nancy Leone, Cristina Labate, Maria Penelope De Santo, Marco Lombardo
Keratoconus is the primary cause of corneal transplantation in young adults worldwide. Riboflavin/UV-A corneal cross-linking may effectively halt the progression of keratoconus if an adequate amount of riboflavin enriches the corneal stroma and is photo-oxidated by UV-A light for generating additional cross-linking bonds between stromal proteins and strengthening the biomechanics of the weakened cornea. Here we reported a UV-A theranostic prototype device for performing corneal cross-linking with the ability to assess corneal intrastromal concentration of riboflavin and to estimate treatment efficacy in real time...
February 16, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29450545/use-of-the-posterior-anterior-corneal-curvature-radii-ratio-to-improve-the-accuracy-of-intraocular-lens-power-calculation-eom-s-adjustment-method
#17
Mingue Kim, Youngsub Eom, Hwa Lee, Young-Woo Suh, Jong Suk Song, Hyo Myung Kim
Purpose: To evaluate the accuracy of IOL power calculation using adjusted corneal power according to the posterior/anterior corneal curvature radii ratio. Methods: Nine hundred twenty-eight eyes from 928 reference subjects and 158 eyes from 158 cataract patients who underwent phacoemulsification surgery were enrolled. Adjusted corneal power of cataract patients was calculated using the fictitious refractive index that was obtained from the geometric mean posterior/anterior corneal curvature radii ratio of reference subjects and adjusted anterior and predicted posterior corneal curvature radii from conventional keratometry (K) using the posterior/anterior corneal curvature radii ratio...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29450535/a-spatiotemporal-requirement-for-prickle-1-mediated-pcp-signaling-in-eyelid-morphogenesis-and-homeostasis
#18
Dianlei Guo, Zhaohui Yuan, Jiali Ru, Xinyu Gu, Wang Zhang, Fuxiang Mao, Hong Ouyang, Kaili Wu, Yizhi Liu, Chunqiao Liu
Purpose: Tissue closure/fusion is a fundamental process during organogenesis, driven in part by the Wnt/planar cell polarity (Wnt/PCP) pathway. This study explored the spatial and temporal aspects of PCP signaling in eyelid development through analysis of mice lacking Prickle 1, a core PCP component, and the Prickle1-dependent signaling networks underlying eyelid development. Methods: Wild type and Prickle 1 compound mutant mice with a hypomorphic and a null allele were bred and used to study eyelid morphogenesis...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29450106/optical-system-design-for-noncontact-normal-incidence-thz-imaging-of-in-vivo-human-cornea
#19
Shijun Sung, Shahab Dabironezare, Nuria Llombart, Skyler Selvin, Neha Bajwa, Somporn Chantra, Bryan Nowroozi, James Garritano, Jacob Goell, Alex Li, Sophie X Deng, Elliott Brown, Warren S Grundfest, Zachary D Taylor
Reflection mode Terahertz (THz) imaging of corneal tissue water content (CTWC) is a proposed method for early, accurate detection and study of corneal diseases. Despite promising results from ex vivo and in vivo cornea studies, interpretation of the reflectivity data is confounded by the contact between corneal tissue and dielectric windows used to flatten the imaging field. Herein, we present an optical design for non-contact THz imaging of cornea. A beam scanning methodology performs angular, normal incidence sweeps of a focused beam over the corneal surface while keeping the source, detector, and patient stationary...
January 2018: IEEE Transactions on Terahertz Science and Technology
https://www.readbyqxmd.com/read/29445990/time-dependent-lxr-rxr-pathway-modulation-characterizes-capillary-remodeling-in-inflammatory-corneal-neovascularization
#20
Anthony Mukwaya, Anton Lennikov, Maria Xeroudaki, Pierfrancesco Mirabelli, Mieszko Lachota, Lasse Jensen, Beatrice Peebo, Neil Lagali
Inflammation in the normally immune-privileged cornea can initiate a pathologic angiogenic response causing vision-threatening corneal neovascularization. Inflammatory pathways, however, are numerous, complex and are activated in a time-dependent manner. Effective resolution of inflammation and associated angiogenesis in the cornea requires knowledge of these pathways and their time dependence, which has, to date, remained largely unexplored. Here, using a model of endogenous resolution of inflammation-induced corneal angiogenesis, we investigate the time dependence of inflammatory genes in effecting capillary regression and the return of corneal transparency...
February 14, 2018: Angiogenesis
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