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https://www.readbyqxmd.com/read/29161204/effect-of-neoadjuvant-chemoradiotherapy-on-health-related-quality-of-life-in-esophageal-or-junctional-cancer-results-from-the-randomized-cross-trial
#1
Bo Jan Noordman, Mathilde G E Verdam, Sjoerd M Lagarde, Maarten C C M Hulshof, Pieter van Hagen, Mark I van Berge Henegouwen, Bas P L Wijnhoven, Hanneke W M van Laarhoven, Grard A P Nieuwenhuijzen, Geke A P Hospers, Johannes J Bonenkamp, Miguel A Cuesta, Reinoud J B Blaisse, Olivier R Busch, Fiebo J W Ten Kate, Geert-Jan M Creemers, Cornelis J A Punt, John Th M Plukker, Henk M W Verheul, Ernst J Spillenaar Bilgen, Herman van Dekken, Maurice J C van der Sangen, Tom Rozema, Katharina Biermann, Jannet C Beukema, Anna H M Piet, Caroline M van Rij, Janny G Reinders, Hugo W Tilanus, Ewout W Steyerberg, Ate van der Gaast, Mirjam A G Sprangers, J Jan B van Lanschot
Purpose To compare pre-agreed health-related quality of life (HRQOL) domains in patients with esophageal or junctional cancer who received neoadjuvant chemoradiotherapy (nCRT) followed by surgery or surgery alone. Secondary aims were to examine the effect of nCRT on HRQOL before surgery and the effect of surgery on HRQOL. Patients and Methods Patients were randomly assigned to nCRT (carboplatin plus paclitaxel with concurrent 41.4-Gy radiotherapy) followed by surgery or surgery alone. HRQOL was measured using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (QLQ-C30) and -Oesophageal Cancer Module (QLQ-OES24) questionnaires pretreatment and at 3, 6, 9, and 12 months postoperatively...
November 21, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29159777/prognostic-factors-for-survival-in-adult-patients-with-recurrent-glioblastoma-a-decision-tree-based-model
#2
Etienne Audureau, Anaïs Chivet, Renata Ursu, Robert Corns, Philippe Metellus, Georges Noel, Sonia Zouaoui, Jacques Guyotat, Pierre-Jean Le Reste, Thierry Faillot, Fabien Litre, Nicolas Desse, Antoine Petit, Evelyne Emery, Emmanuelle Lechapt-Zalcman, Johann Peltier, Julien Duntze, Edouard Dezamis, Jimmy Voirin, Philippe Menei, François Caire, Phong Dam Hieu, Jean-Luc Barat, Olivier Langlois, Jean-Rodolphe Vignes, Pascale Fabbro-Peray, Adeline Riondel, Elodie Sorbets, Marc Zanello, Alexandre Roux, Antoine Carpentier, Luc Bauchet, Johan Pallud
We assessed prognostic factors in relation to OS from progression in recurrent glioblastomas. Retrospective multicentric study enrolling 407 (training set) and 370 (external validation set) adult patients with a recurrent supratentorial glioblastoma treated by surgical resection and standard combined chemoradiotherapy as first-line treatment. Four complementary multivariate prognostic models were evaluated: Cox proportional hazards regression modeling, single-tree recursive partitioning, random survival forest, conditional random forest...
November 20, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29159255/comparative-diagnostic-performance-of-the-granulocyte-and-neutrophil-counts
#3
Nicola S Pether, Jessica L Brothwood, Cornelis van Berkel, Elaine H Dunwoodie, Robert L Blake, Christopher P Price, Richard G Jones, Karl S Baker, Geoff Hall
Objectives: Use of point-of-care testing is increasing, however many haematology analysers can only determine granulocyte count without further differentiation into neutrophils, eosinophils and basophils. Since the diagnosis of life-threatening neutropenia in cancer patients requires a distinct neutrophil count, this study aimed to determine the comparative performance between the neutrophil and granulocyte count. Design and methods: A database of 508 646 venous full blood count results measured on a laboratory reference analyser was mined from a large oncology unit...
December 2017: Pract Lab Med
https://www.readbyqxmd.com/read/29157901/inducible-cellulase-production-from-an-organic-solvent-tolerant-bacillus-sp-sv1-and-evolutionary-divergence-of-endoglucanase-in-different-species-of-the-genus-bacillus
#4
Lebin Thomas, Hari Ram, Ved Pal Singh
Bacteria are important sources of cellulases with various industrial and biotechnological applications. In view of this, a non-hemolytic bacterial strain, tolerant to various environmental pollutants (heavy metals and organic solvents), showing high cellulolytic index (7.89) was isolated from cattle shed soil and identified as Bacillus sp. SV1 (99.27% pairwise similarity with Bacillus korlensis). Extracellular cellulases showed the presence of endoglucanase, total cellulase and β-glucosidase activities. Cellulase production was induced in presence of cellulose (3...
November 6, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29157871/using-millet-as-substrate-for-efficient-production-of-monacolin-k-by-solid-state-fermentation-of-monascus-ruber
#5
Bo-Bo Zhang, Hong-Bo Xing, Bing-Jie Jiang, Lei Chen, Gan-Rong Xu, Yun Jiang, Da-Yong Zhang
In this study, various grains such as rice, millet, corn, barley and wheat were used as raw materials for monacolin K production by solid-state fermentation of Monascus ruber. Among these substrates, millet was found to be the best one for monacolin K production, by which the yield reached 7.12 mg/g. For enhanced monacolin K production, the effects of fermentation time, charge amount, initial moisture content and inoculum volume were systematically investigated in the solid-state fermentation of M. ruber. Moreover, complementary carbon source and nitrogen source were added for further improving the production of monacolin K...
November 17, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29157662/evaluation-of-guideline-adherence-in-colorectal-cancer-treatment-in-the-netherlands-a-survey-among-medical-oncologists-by-the-dutch-colorectal-cancer-group
#6
Lotte Keikes, Martijn G H van Oijen, Valery E P P Lemmens, Miriam Koopman, Cornelis J A Punt
BACKGROUND: Clinical guidelines are generated to preserve high-quality evidence-based care. Data on the implementation of guidelines into clinical practice are scarce, despite that guideline adherence prevents over- and undertreatment and correlates with survival. Therefore, we investigated guideline adherence for the systemic treatment in high-risk stage II and stage III colon cancer and metastatic colorectal cancer. PATIENTS AND METHODS: In all Dutch hospitals (n = 88) 1 medical oncologist involved in colorectal cancer care was approached to participate...
November 17, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29156391/optimal-allocation-of-physical-water-resources-integrated-with-virtual-water-trade-in-water-scarce-regions-a-case-study-for-beijing-china
#7
Quanliang Ye, Yi Li, La Zhuo, Wenlong Zhang, Wei Xiong, Chao Wang, Peifang Wang
This study provides an innovative application of virtual water trade in the traditional allocation of physical water resources in water scarce regions. A multi-objective optimization model was developed to optimize the allocation of physical water and virtual water resources to different water users in Beijing, China, considering the trade-offs between economic benefit and environmental impacts of water consumption. Surface water, groundwater, transferred water and reclaimed water constituted the physical resource of water supply side, while virtual water flow associated with the trade of five major crops (barley, corn, rice, soy and wheat) and three livestock products (beef, pork and poultry) in agricultural sector (calculated by the trade quantities of products and their virtual water contents)...
November 14, 2017: Water Research
https://www.readbyqxmd.com/read/29156230/transport-of-a-neonicotinoid-pesticide-thiamethoxam-from-artificial-seed-coatings
#8
Jesse Radolinski, Junxue Wu, Kang Xia, Ryan Stewart
Neonicotinoid insecticides coat the seeds of major crops worldwide; however, the high solubility of these compounds, combined with their toxicity to non-target organisms, makes it critical to decipher the processes by which they are transported through soils and into aquatic environments. Transport and distribution of a neonicotinoid (thiamethoxam, TMX) were investigated by growing TMX-coated corn seeds in coarse-textured and fine-textured soil columns (20 and 60cm lengths). To understand the influence of living plants, corn plants were terminated in half of the columns (no plant treatment) and allowed to grow to the V5 growth stage (33days of growth) in the other half (with plant treatment)...
November 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29155485/advantages-of-diapause-in-trichogramma-dendrolimi-mass-production-via-eggs-of-the-chinese-silkworm-antheraea-pernyi
#9
Jun-Jie Zhang, Xue Zhang, Lian-Sheng Zang, Wen-Mei Du, Yang-Yang Hou, Chang-Chun Ruan, Nicolas Desneux
BACKGROUND: Trichogramma dendrolimi Matsumura is widely used as biological control agent for lepidopteran agricultural pests control in China and can be successfully reared using the large eggs of the Chinese silkworm, Antheraea pernyi. In this study, biological parameters of diapaused, non-diapaused, and cold-stored T. dendrolimi were investigated for two generations on host eggs of A. pernyi under the laboratory conditions. RESULTS: The cold-stored T. dendrolimi performed poorer than diapaused and non-diapaused T...
November 20, 2017: Pest Management Science
https://www.readbyqxmd.com/read/29154215/error-propagation-of-partial-least-squares-for-parameters-optimization-in-nir-modeling
#10
Chenzhao Du, Shengyun Dai, Yanjiang Qiao, Zhisheng Wu
A novel methodology is proposed to determine the error propagation of partial least-square (PLS) for parameters optimization in near-infrared (NIR) modeling. The parameters include spectral pretreatment, latent variables and variable selection. In this paper, an open source dataset (corn) and a complicated dataset (Gardenia) were used to establish PLS models under different modeling parameters. And error propagation of modeling parameters for water quantity in corn and geniposide quantity in Gardenia were presented by both type І and type II error...
October 28, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29154147/selecting-the-minimum-data-set-and-quantitative-soil-quality-indexing-of-alkaline-soils-under-different-land-uses-in-northeastern-china
#11
Pujia Yu, Shiwei Liu, Liang Zhang, Qiang Li, Daowei Zhou
Understanding the influences of land use conversions on soil quality (SQ) and function are essential to adopt proper agricultural management practices for a specific region. The primary objective of this study was to develop soil quality indices (SQIs) to assess the short-term influences of different land uses on SQ in semiarid alkaline grassland in northeastern China. Land use treatments were corn cropland (Corn), alfalfa perennial forage (Alfalfa), monoculture Lyemus chinensis grassland (MG) and successional regrowth grassland (SRG), which were applied for five years...
November 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29154116/lanthanum-toxicity-to-five-different-species-of-soil-invertebrates-in-relation-to-availability-in-soil
#12
Jinxia Li, Rudo A Verweij, Cornelis A M van Gestel
This study determined the toxicity of lanthanum, one of the most commonly used rare earth elements (REEs), to five representative soil invertebrates after 3-4 weeks exposure. Toxicity was related to total, 0.01 M CaCl2-extractable and porewater concentrations in the standard LUFA 2.2 soil, and for earthworms also to body concentrations. La sorption to LUFA 2.2 soil, estimated by relating total soil concentrations to CaCl2-extractable or porewater concentrations seemed to reach saturation at >1000 mg La/kg dry soil...
November 10, 2017: Chemosphere
https://www.readbyqxmd.com/read/29153644/propionic-acid-production-from-soy-molasses-by-propionibacterium-acidipropionici-fermentation-kinetics-and-economic-analysis
#13
Hopen Yang, Zhongqiang Wang, Meng Lin, Shang-Tian Yang
Propionic acid (PA) is a specialty chemical; its calcium salt is widely used as food preservative. Soy molasses (SM), a low-value byproduct from soybean refinery, contains sucrose and raffinose-family oligosaccharides (RFO), which are difficult to digest for most animals and industrial microorganisms. The feasibility of using SM for PA production by P. acidipropionici, which has genes encoding enzymes necessary for RFO hydrolysis, was studied. With corn steep liquor as the nitrogen source, stable long-term PA production from SM was demonstrated in sequential batch fermentations, achieving PA productivity of >0...
November 8, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29153529/evaluation-of-carinata-meal-as-a-feedstuff-for-growing-dairy-heifers-effects-on-growth-performance-rumen-fermentation-and-total-tract-digestibility-of-nutrients
#14
K Rodriguez-Hernandez, J L Anderson
Our objective was to determine the effects of feeding carinata meal (CRM) compared with distillers dried grains with solubles (DDGS) on growth performance, rumen fermentation, and nutrient utilization in peripubertal dairy heifers. A 16-wk randomized block design experiment with 24 Holstein heifers [6.6 ± 0.7 mo and 218 ± 27 kg of body weight (BW)] was conducted. Treatments diets were (1) 10% cold-pressed CRM and (2) 10% DDGS on a dry matter (DM) basis. The remainder of the diets consisted of grass hay, ground corn, soybean meal, and mineral mix...
November 15, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29153158/a-100-year-review-metabolic-modifiers-in-dairy-cattle-nutrition
#15
R K McGuffey
The first issue of the Journal of Dairy Science in 1917 opened with the text of the speech by Raymond A. Pearson, president of the Iowa State College of Agriculture, at the dedication of the new dairy building at the University of Nebraska (J. Dairy Sci. 1:4-18, 1917). Fittingly, this was the birth of a new research facility and more importantly, the beginning of a new journal devoted to the sciences of milk production and manufacture of products from milk. Metabolic modifiers of dairy cow metabolism enhance, change, or interfere with normal metabolic processes in the ruminant digestive tract or alter postabsorption partitioning of nutrients among body tissues...
December 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29153069/-emerging-pathogen-candida-kefyr-kluvyeromyces-marxianus
#16
Tuğba Çuhadar, Ayşe Kalkancı
In the central microbiology laboratory of Gazi University Hospital Candida kefyr was isolated from different clinical samples as 5.3% in 2016 and in 2017 this rate increased to 9.3% which was nearly two-fold and this has drawn our attention. The aim of this study was to evaluate the special characteristics, antifungal susceptibility and virulence properties of C.keyfr species. Germ tube, corn meal-tween 80 agar morphology and carbohydrate assimilation profiles on ID32C yeast identification system were used for the diagnosis of Candida species...
October 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29152102/l1-cell-adhesion-molecule-l1cam-is-a-strong-predictor-for-locoregional-recurrences-in-cervical-cancer
#17
Marlies Schrevel, Willem E Corver, Margit E Vegter, Natalja T Ter Haar, Enno J Dreef, Jogchum J Beltman, Gemma Kenter, Tjalling Bosse, Cornelis D de Kroon, Ekaterina S Jordanova
Background: L1 cell adhesion molecule (L1CAM) has been shown to be a prognostic marker in various cancer types, and has been suggested to play a role in epithelial mesenchymal transition (EMT). Here, we determined the prognostic significance of L1CAM in cervical cancer and its association with vimentin expression on tumor cells, indicative of EMT. Methods: Formalin-fixed, paraffin-embedded primary tumor samples from 372 cervical cancer patients were collected for immunohistochemical analysis of L1CAM expression...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29152074/vanillic-acid-attenuates-testosterone-induced-benign-prostatic-hyperplasia-in-rats-and-inhibits-proliferation-of-prostatic-epithelial-cells
#18
Yunu Jung, Jinbong Park, Hye-Lin Kim, Dong-Hyun Youn, JongWook Kang, Seona Lim, Mi-Young Jeong, Gautam Sethi, Sung-Joo Park, Kwang Seok Ahn, Jae-Young Um
Benign prostatic hyperplasia (BPH) is a common disease in the male population, especially in elderly men. Vanillic acid (VA), a dihydroxybenzoic derivative used as a flavoring agent, is reported to have an anti-inflammatory effect. However, there are no reports of its effects on BPH to date. BPH was induced with a pre-4-week treatment of daily subcutaneous injections of testosterone propionate (TP), and the normal control group received injections of ethanol with corn oil instead. Six weeks of further injections were done with (a) ethanol with corn oil, (b) TP only, (c) TP + finasteride, and (d) TP + VA...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29151994/antimicrobial-activity-of-cultivable-endophytic-fungi-associated-with-hancornia-speciosa-gomes-bark
#19
Mardonny Bruno de Oliveira Chagas, Irailton Prazeres Dos Santos, Luis Claudio Nascimento da Silva, Maria Tereza Dos Santos Correia, Janete Magali de Araújo, Marilene da Silva Cavalcanti, Vera Lucia de Menezes Lima
Introduction: In this study, we evaluated the antimicrobial potential of cultivable endophytic fungi associated with Hancornia speciosa Gomes stem bark. Methods and Materials: Plant samples were collected in rainy (July 2010) and dry (January 2011) seasons. In total, 116 endophytic fungi strains were isolated from 90 fragments (64.4% frequency of colonization). Higher fungi frequency was observed in the rainy season (84.4%). The strains were grouped into 14 species; the most frequent were Phoma cava (13...
2017: Open Microbiology Journal
https://www.readbyqxmd.com/read/29151888/enhancing-biogas-plant-production-using-pig-manure-and-corn-silage-by-adding-wheat-straw-processed-with-liquid-hot-water-and-steam-explosion
#20
Michał Gaworski, Sławomir Jabłoński, Izabela Pawlaczyk-Graja, Rafał Ziewiecki, Piotr Rutkowski, Anna Wieczyńska, Roman Gancarz, Marcin Łukaszewicz
Background: Pig manure utilization and valorization is an important topic with tightening regulations focused on ecological and safety issues. By itself pig manure is a poor substrate for biogas production because of its excessive nitrogen content relative to available organic carbon. Such substrate is alkaline, and methanogenesis can be suppressed, and so additional substrates with high organic carbon must be added. The most promising is straw, which is available from adjacent biogas plant cultures...
2017: Biotechnology for Biofuels
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