keyword
https://read.qxmd.com/read/38412750/perimenopausal-abnormal-uterine-bleeding
#21
REVIEW
Eva Dreisler, Christian Seerup Frandsen, Lian Ulrich
Abnormal uterine bleeding is a frequent symptom in the perimenopause. Causes are numerous, ranging from physiological reactions due to decreasing/unstable ovarian function to premalignant and malignant conditions. Benign findings such as endometrial polyps and myomas increase with age, leading to more abnormal uterine bleeding in the perimenopause. Cervical and vaginal causes of abnormal uterine bleeding should be excluded by speculum examination. Sexually transmitted diseases or pregnancy should be ruled out...
February 22, 2024: Maturitas
https://read.qxmd.com/read/38412592/the-role-of-estrogen-receptor-gene-polymorphisms-in-menopausal-symptoms-and-estradiol-levels-in-perimenopausal-women-findings-from-the-swiss-perimenopause-study
#22
JOURNAL ARTICLE
Jessica Grub, Jasmine Willi, Hannah Süss, Ulrike Ehlert
OBJECTIVES: Fluctuating estradiol (E2) levels seem to be associated with menopausal symptoms, though not all women suffer from these symptoms to the same extent despite experiencing these hormonal changes. This suggests underlying, interindividual mechanisms, such as single-nucleotide polymorphisms (SNPs) influencing estrogen receptors α and β, and the g-protein-coupled estrogen receptor (GPER). As research is scarce, we aimed to address this research gap by assessing genetic traits, E2 levels, and menopausal symptoms longitudinally...
February 21, 2024: Maturitas
https://read.qxmd.com/read/38404042/sharing-the-multidisciplinary-clinical-approach-to-peri-and-postmenopausal-women-a-delphi-consensus-among-italian-gynecologists-endocrinologists-and-cardiologists-for-an-integrated-and-optimal-approach-to-clinical-practice
#23
JOURNAL ARTICLE
Nicola Colacurci, Pasquale Perrone Filardi, Antonio Chiantera, Annamaria Colao, Patrizio Pasqualetti, Andrea Lenzi
OBJECTIVE: The critical phase of perimenopausal period is marked by a reduction in estrogen levels, leading to various clinical issues (vasomotor and neurodegenerative symptoms, increased osteoporosis risk and cardiovascular risk). These complex clinical scenarios pose challenges to clinicians in providing the right support for diagnosis and treatment. A group of Italian cardiologists, endocrinologists, and gynecologists conducted a survey among expert colleagues to assess consensus on controversial issues and best practices for screening and treating peri- and postmenopausal women...
February 25, 2024: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/38404005/cyclin-dependent-kinase-4-6-inhibitors-in-the-treatment-of-advanced-or-metastatic-breast-cancer
#24
REVIEW
John P Micha, Mark A Rettenmaier, Randy D Bohart, Bram H Goldstein
OBJECTIVE: Despite the relatively high cure rates in early-stage breast cancer, advanced and metastatic breast cancer cases are associated with more inauspicious patient outcomes. Fortunately, with the advent of cyclin-dependent kinase (CDK)4/6 inhibitors (e.g. palbociclib, ribociclib, and abemaciclib) with endocrine therapy, survival in advanced and metastatic breast cancer has appreciably improved. In the current review, we discuss these distinctions and the concomitant implications associated with the individual CDK4/6 inhibitors...
February 25, 2024: Journal of Oncology Pharmacy Practice
https://read.qxmd.com/read/38394165/association-of-oxidative-stress-and-proinflammation-with-insomnia-in-perimenopause
#25
JOURNAL ARTICLE
Jing Zhao, Yubo Ji, Yanni Zuo, Long Zhang, Congwen Ku, Wenyan Wang, Pengxiang Wang, Yan Yang, Yimin Kang, Fan Wang
Background: The levels of oxidative stress and proinflammatory factors in perimenopausal females increased, and they were also deeply troubled by insomnia. The occurrence of insomnia is related to the changes of oxidative stress and inflammation levels in the body. Perimenopausal insomnia may be related to mild systemic inflammation, and oxidative stress can promote chronic inflammation. However, the underlying mechanism behind the phenomenon is still unclear. Objective: The aim was to investigate whether the occurrence of perimenopausal insomnia disorder is related to higher levels of oxidative stress and inflammation in the body, and to explore the role of inducible nitric oxide synthase (iNOS) in perimenopausal insomnia...
February 23, 2024: Journal of Women's Health
https://read.qxmd.com/read/38393976/menopause-and-the-role-of-physical-activity-the-views-and-knowledge-of-women-aged-40-65
#26
JOURNAL ARTICLE
David Wasley, Samantha Gailey
Menopause marks the end of female reproductive capacity. It is defined as the point after cessation of the menstrual cycle for 12 months (Nursat et al., 2008). Awareness about menopause has increased over the last decade, yet studies have shown that women still lack knowledge regarding the subject. Likewise, awareness of women between the age of 40-65 on the potential role of physical activity prior to and during menopause in women is unclear. Women ( n = 162) aged 40-65 years completed a survey rating their knowledge, answered fact-based questions and reported their experiences of menopause...
February 23, 2024: Post Reproductive Health
https://read.qxmd.com/read/38392617/how-sex-hormones-affect-migraine-an-interdisciplinary-preclinical-research-panel-review
#27
REVIEW
Frederick Godley, John Meitzen, Hadas Nahman-Averbuch, Mary Angela O'Neal, David Yeomans, Nanette Santoro, Nina Riggins, Lars Edvinsson
Sex hormones and migraine are closely interlinked. Women report higher levels of migraine symptoms during periods of sex hormone fluctuation, particularly during puberty, pregnancy, and perimenopause. Ovarian steroids, such as estrogen and progesterone, exert complex effects on the peripheral and central nervous systems, including pain, a variety of special sensory and autonomic functions, and affective processing. A panel of basic scientists, when challenged to explain what was known about how sex hormones affect the nervous system, focused on two hormones: estrogen and oxytocin...
February 7, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38389168/tales-from-the-clinic-hormone-replacement-therapy-hrt-in-perimenopausal-women-with-migraine
#28
JOURNAL ARTICLE
E Anne MacGregor, Paula Briggs
No abstract text is available yet for this article.
February 22, 2024: Post Reproductive Health
https://read.qxmd.com/read/38388751/quercetin-alleviates-perimenopausal-depression-induced-by-ovariectomy-combined-with-chronic-unpredictable-mild-stress-through-regulating-serum-elements-and-inhibiting-ferroptosis-in-prefrontal-cortex-of-rats
#29
JOURNAL ARTICLE
Dan Wang, Jing Wang, Ziran Yu, Ranqi Yao, Jingnan Zhang, Xiujuan Zhao
This study investigated the effects of quercetin on the alterations of serum elements in perimenopausal depression rat model induced by ovariectomy combined with chronic unpredictable mild stress (OVX-CUMS) and possible mechanisms. According to the results of the sucrose preference test, the rats were randomly assigned to four groups: sham, OVX-CUMS, OVX-CUMS + 17β-estradiol (17β-estradiol: 0.27 mg/kg.bw), and OVX-CUMS + Quercetin (Quercetin: 50 mg/kg.bw). At the end of experiment, serum and prefrontal cortex of rats were collected...
February 22, 2024: Biological Trace Element Research
https://read.qxmd.com/read/38385729/circulating-cell-free-dna-is-elevated-in-postmenopausal-compared-with-pre-and-perimenopausal-women
#30
JOURNAL ARTICLE
Teagan Fisher, Elyse Powell, Nicole L Yuwono, Caroline E Ford, Kristina Warton
OBJECTIVE: With the rising use of circulating cell-free DNA (cirDNA) liquid biopsies for disease screening, it is important to understand biological differences that may impact the accuracy of cirDNA-based clinical tests. Although a number of biological factors have been researched, the relationship between menopause and cirDNA has not been thoroughly investigated. We aimed to compare plasma cirDNA concentration and DNA fragment integrity in healthy women pre- and postmenopause. METHODS: Blood was collected from healthy female volunteers 40 years and older...
March 1, 2024: Menopause: the Journal of the North American Menopause Society
https://read.qxmd.com/read/38377443/does-menopause-hormone-therapy-improve-symptoms-of-depression-findings-from-a-specialized-menopause-clinic
#31
JOURNAL ARTICLE
Rahavi Gnanasegar, Wendy Wolfman, Leticia Hernandez Galan, Amie Cullimore, Alison K Shea
OBJECTIVE: Depressive symptoms are commonly reported during the perimenopause and in the early postmenopausal years. Although menopausal hormone therapy (MHT) is considered the most effective treatment option for vasomotor symptoms, its effect on mood-related symptoms is less established. This study aims to assess interval change in depressive symptoms after initiation of MHT treatment in women seeking care at a Canadian specialized menopause clinic. METHODS: Women and female-presenting people attending the St...
February 20, 2024: Menopause: the Journal of the North American Menopause Society
https://read.qxmd.com/read/38368570/-quality-of-life-in-perimenopausal-women-affected-by-covid-19-pandemic
#32
JOURNAL ARTICLE
Edina Dombi, Renáta Kovács-Berta, Zsófia Kaufmann, Petra Völgyesi, Zoltán Pál
No abstract text is available yet for this article.
February 18, 2024: Orvosi Hetilap
https://read.qxmd.com/read/38363540/menopausal-hormone-therapy-in-women-with-type-2-diabetes-mellitus-an-updated-review
#33
REVIEW
Stavroula A Paschou, Kleoniki I Athanasiadou, Nikolaos Papanas
Menopause is accompanied by several metabolic adaptations, which are related to insulin resistance, increased total body fat mass, and central abdominal fat accumulation, predisposing women to type 2 diabetes mellitus (T2DM) development. Metabolic syndrome has a high prevalence in postmenopausal women, indicating the loss of estrogen protection on metabolic and cardiovascular health. Moreover, earlier age at menopause has been related to increased risk of T2DM. Menopausal hormone therapy (MHT) has favorable results in glucose metabolism...
February 16, 2024: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/38358576/mixed-method-multilevel-clustered-randomized-control-trial-for-menstrual-health-disparities
#34
JOURNAL ARTICLE
Lauren C Houghton, Paris B Adkins-Jackson
Menstrual cycle characteristics are largely considered unmodifiable reproductive factors, a framing that prevents exploration of the ways structural factors interfere with menstrual health. Given the role of structural factors like healthy food and healthcare access on reproductive health and the grave need for structural interventions to known reproductive health disparities that disproportionately target cisgender women racialized as Black, it is imperative that science begin to examine how structural factors influence menstrual health...
February 15, 2024: Prevention Science: the Official Journal of the Society for Prevention Research
https://read.qxmd.com/read/38357914/circulating-endogenous-sex-steroids-and-risk-of-differentiated-thyroid-carcinoma-in-men-and-women
#35
JOURNAL ARTICLE
Sabina Rinaldi, Laure Dossus, Pekka Keski-Rahkonen, Agneta Kiss, Anne-Sophie Navionis, Carine Biessy, Ruth Travis, Elisabete Weiderpass, Isabelle Romieu, Anne Kirstine Eriksen, Anne Tjonneland, Marina Kvaskoff, Marianne Canonico, Thérèse Truong, Verena Katzke, Rudolf Kaaks, Alberto Catalano, Salvatore Panico, Giovanna Masala, Rosario Tumino, Marko Lukic, Karina Standahl Olsen, Raul Zamora-Ros, Carmen Santiuste, Amaia Aizpurua Atxega, Marcela Guevara, Miguel Rodriguez-Barranco, Maria Sandstrom, Joakim Hennings, Martin Almquist, Elom Aglago Kouassivi, Sofia Christakoudi, Marc Gunter, Silvia Franceschi
Thyroid cancer (TC) is substantially more common in women than in men, pointing to a possible role of sex steroid hormones. We investigated the association between circulating sex steroid hormones, sex hormone binding globulin (SHBG) and the risk of differentiated TC in men and women within the European Prospective Investigation into Cancer and nutrition (EPIC) cohort. During follow-up, we identified 333 first primary incident cases of differentiated TC (152 in pre/peri-menopausal women, 111 in post-menopausal women, and 70 in men) and 706 cancer-free controls...
February 15, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38350036/the-association-of-depressive-symptoms-and-female-sexual-functioning-in-the-menopause-transition-a-cross-sectional-study
#36
JOURNAL ARTICLE
Emily B Stevens, Wendy Wolfman, Leticia Hernandez-Galan, Alison K Shea
OBJECTIVE: Sexual dysfunction is very common among middle-aged females. Several factors are considered to influence sexual functioning, including reproductive aging and associated physiological changes as well as life stressors, mental health, and other socioeconomic influences. The objectives of this study are to evaluate the effect of current depressive symptoms on sexual functioning during menopause and to further analyze whether socioeconomic status, age, and antidepressant usage impact this association...
February 13, 2024: Menopause: the Journal of the North American Menopause Society
https://read.qxmd.com/read/38336815/vagibiom-lactobacillus-suppository-improves-vaginal-health-index-in-perimenopausal-women-with-bacterial-vaginosis-a-randomized-control-trial
#37
JOURNAL ARTICLE
Vijitha Vivekanandan, Zaiba Hasan Khan, Giriprasad Venugopal, Bhavana Musunuru, Priyanka Mishra, Shalini Srivastava, Balamurugan Ramadass, Bobban Subhadra
Bacterial vaginosis (BV) can cause vaginal dysbiosis that may influence general vaginal health and pregnancy complications. Balancing vaginal microbiome using Lactobacillus spp. may be a new way to prevent and treat mild BV. We conducted a randomized, double-blind, placebo-controlled pilot study aimed at evaluating the effect of the product VagiBIOM, a multi-Lactobacillus vaginal suppository, on peri- and premenopausal women with BV in restoring vaginal pH and overall vaginal health by resetting the vaginal microbiome composition...
February 9, 2024: Scientific Reports
https://read.qxmd.com/read/38336466/a-systematic-review-and-critical-appraisal-of-menopause-guidelines
#38
JOURNAL ARTICLE
Chandima Hemachandra, Sasha Taylor, Rakibul M Islam, Ensieh Fooladi, Susan R Davis
OBJECTIVE AND RATIONALE: To identify and appraise current national and international clinical menopause guidance documents, and to extract and compare the recommendations of the most robust examples. DESIGN: Systematic review. DATA SOURCES: Ovid MEDLINE, EMBASE, PsycINFO and Web of Science ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Practice guidance documents for menopause published from 2015 until 20 July 2023. Quality was assessed by the Appraisal of Guidelines for Research and Evaluation II (AGREE II) instrument...
February 22, 2024: BMJ Sexual & Reproductive Health
https://read.qxmd.com/read/38325021/health-related-quality-of-life-by-31-item-cervantes-scale-in-breast-cancer-survivors-undergoing-adjuvant-endocrine-therapy
#39
JOURNAL ARTICLE
Isis Danyelle Dias Custódio, Fernanda Silva Mazzutti Nunes, Mariana Tavares Miranda Lima, Kamila Pires de Carvalho, Andressa Miranda Machado, Paula Philbert Lajolo, Carlos Eduardo Paiva, Yara Cristina de Paiva Maia
INTRODUCTION: Instruments to manage adverse effects of endocrine therapy with Aromatase inhibitors (AI) may improve adherence and persistence to treatment and Health-Related Quality of Life (HRQL). The 31-item Cervantes Scale (CS-31) is an HRQL questionnaire with particularities of the perimenopausal and postmenopausal period that could be an appropriate instrument to assess HRQL in Breast Cancer (BC) survivors. OBJECTIVE: This study aimed to perform additional validation of the CS-31 for BC survivors undergoing adjuvant endocrine therapy...
February 6, 2024: Clinics
https://read.qxmd.com/read/38323149/women-s-comfort-with-mobile-applications-for-menstrual-cycle-self-monitoring-following-the-overturning-of-roe-v-wade
#40
JOURNAL ARTICLE
Gabrielle M Salvatore, Iris Bercovitz, Danielle Arigo
BACKGROUND: The overturning of Roe v. Wade in June 2022 has many implications for American women of reproductive age, as well as for researchers focused on women's health in the United States (U.S.). Personal reproductive health data, such as information collected by menstrual cycle (MC) tracking applications (apps), can now be bought, sold, or accessed by law enforcement to enforce limits on abortion. American women have grown concerned about data privacy and have even deleted MC tracking apps following the overturning of Roe v...
2024: MHealth
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