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https://www.readbyqxmd.com/read/29322164/efficacy-of-transdermal-estradiol-and-micronized-progesterone-in-the-prevention-of-depressive-symptoms-in-the-menopause-transition-a-randomized-clinical-trial
#1
Jennifer L Gordon, David R Rubinow, Tory A Eisenlohr-Moul, Kai Xia, Peter J Schmidt, Susan S Girdler
Importance: The menopause transition and early postmenopausal period are associated with a 2- to 4-fold increased risk for clinically significant depressive symptoms. Although a few studies suggest that hormone therapy can effectively manage existing depression during this time, to our knowledge, there have been no studies testing whether hormone therapy can prevent the onset of perimenopausal and early postmenopausal depressive symptoms. Objective: To examine the efficacy of transdermal estradiol plus intermittent micronized progesterone (TE+IMP) in preventing depressive symptom onset among initially euthymic perimenopausal and early postmenopausal women...
January 10, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29310403/multilocular-cystic-leiomyoma-of-the-anterolateral-abdominal-wall-a-case-report-and-literature-review
#2
Kenji Yorita, Yu Tanaka, Koki Hirano, Michio Kuwahara, Kimiko Nakatani, Masaharu Fukunaga, Abbas Agaimy
RATIONALE: Leiomyomas arising from the anterolateral abdominal wall are uncommon, and their pathogenesis remains unknown. We present the 15th case of such a tumor, having this unique tumor morphology, followed by a detailed discussion on disease pathogenesis. PATIENT CONCERNS: A 48-year-old, asymptomatic perimenopausal, multiparous Japanese woman presented with a left-sided pelvic mass. She had no history of previous surgeries or uterine leiomyomas. Although a transabdominal ultrasonogram raised suspicions of an ovarian tumor, a transvaginal ultrasonogram confirmed normal ovaries...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29309514/follicle-stimulating-hormone-levels-and-subclinical-atherosclerosis-in-older-postmenopausal-women
#3
Elizabeth R Bertone-Johnson, Jyrki K Virtanen, Tarja Nurmi, Leo Niskanen, Jaakko Mursu, Sari Voutilainen, Kimmo Ronkainen, Jussi Kauhanen, Tomi-Pekka Tuomainen
Recent studies of perimenopausal women suggest that follicle-stimulating hormone (FSH) levels may be associated with atherosclerosis, independent of estradiol. Whether FSH is related to atherosclerosis in older postmenopausal women, who have completed the menopausal transition, remains unknown. We assessed the relationship of serum FSH and estradiol levels with carotid artery intima-media thickness (IMT) among 587 postmenopausal participants in the Kuopio Ischemic Heart Disease Risk Factor Study (Kuopio, Finland)...
January 1, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29298078/management-of-menopause-symptoms-with-acupuncture-an-umbrella-systematic-review-and-meta-analysis
#4
Deanna Befus, Remy R Coeytaux, Karen M Goldstein, Jennifer R McDuffie, Megan Shepherd-Banigan, Adam P Goode, Andrzej Kosinski, Megan G Van Noord, Soheir S Adam, Varsha Masilamani, Avishek Nagi, John W Williams
OBJECTIVES: Vasomotor symptoms (VMSs) are the most common symptoms reported during menopause. Although hormone therapy is effective for reducing VMSs, its use is restricted in some women. Many women with VMSs thus seek nonhormonal, nonpharmacologic treatment options such as acupuncture. DESIGN: An umbrella systematic review (SR) was conducted, supplemented by a search of published randomized controlled trials (RCTs), that assessed the effectiveness of acupuncture for VMSs, health-related quality of life (HRQOL), and adverse effects of treatment in perimenopausal or postmenopausal women...
January 3, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29290361/dietary-inflammatory-index-and-ovarian-cancer-risk-in-a-new-jersey-case-control-study
#5
Nitin Shivappa, James R Hébert, Lisa E Paddock, Lorna Rodriguez-Rodriguez, Sara H Olson, Elisa V Bandera
OBJECTIVE: Diet may influence the development of ovarian cancer. Although it has been shown that inflammation plays an important etiologic role in ovarian carcinogenesis, little is known about the influence of the inflammatory potential of food consumption. The aim of this study was to evaluate the effect of a proinflammatory diet, as indicated by a high dietary inflammatory index (DII®) score, on ovarian cancer risk, in a New Jersey population. METHODS: Data from a case-control study conducted in New Jersey were used to estimate the relation between DII score and the risk for ovarian cancer...
February 2018: Nutrition
https://www.readbyqxmd.com/read/29290217/variation-in-symptoms-of-depression-and-anxiety-in-midlife-women-by-menopausal-status
#6
Stephanie Mulhall, Ross Andel, Kaarin J Anstey
OBJECTIVES: To examine the association between menopausal status and the risk of symptoms of depression and anxiety in a community-based sample of Australian midlife women. STUDY DESIGN: Female participants (mean age 50.6±1.5) who were premenopausal (n=237), perimenopausal (n=249) or naturally postmenopausal (n=225) were drawn from the Personality and Total Health (PATH) Through Life Project, a longitudinal study. MAIN OUTCOME MEASURES: Symptoms of depression and anxiety were measured using the Goldberg Depression Scale and Goldberg Anxiety Scale...
February 2018: Maturitas
https://www.readbyqxmd.com/read/29285799/biological-effects-of-melatonin-on-osteoblast-osteoclast-co-cultures-bone-and-quality-of-life-implications-of-a-role-for-mt2-melatonin-receptors-mek1-2-and-mek5-in-melatonin-mediated-osteoblastogenesis
#7
Sifat Maria, Rebekah M Samsonraj, Fahima Munmun, Jessica Glas, Maria Silvestros, Mary P Kotlarczyk, Ryan Rylands, Amel Dudakovic, Andre J van Wijnen, Larry T Enderby, Holly Lassila, Bala Dodda, Vicki L Davis, Judy Balk, Matt Burow, Bruce A Bunnell, Paula A Witt-Enderby
The Melatonin Osteoporosis Prevention Study (MOPS) demonstrated that nightly melatonin resulted in a time-dependent decrease in equilibrium ratios of serum osteoclasts and osteoblasts in perimenopausal women. This study examines mechanisms related to the ratios of osteoblasts and osteoclasts using co-culture models (transwell or layered) of human mesenchymal stem cell (MSCs) and human peripheral blood monocytes (PBMCs). Human MSCs/PBMCs co-cultures exposed to melatonin in osteogenic (OS+) medium for 21 days induced osteoblast differentiation and mineralization; however, only in layered co-cultures did melatonin inhibit osteoclastogenesis...
December 28, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/29284236/attitudes-of-women-after-the-age-of-50-towards-preventive-screening
#8
Hanna Skórzyńska, Marlena Krawczyk-Suszek, Teresa B Kulik, Anna Pacian, Agata Stefanowicz, Anna Skowronek
INTRODUCTION: Prevention is one of the major branches of the health sector. The National Health Programme encompasses main risk factors, elimination of which may lead to a reduced incidence of illnesses in the society. At the same time, the criteria of selecting people eligible for preventive screening are established according to risk groups determined by sex, as well as age in the population of women. The perimenopausal and menopausal period contributes to occurrence of numerous systemic diseases and to an increased risk of illnesses, especially cancers...
December 23, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29274928/optimal-adjuvant-endocrine-treatment-of-er-her2-breast-cancer-patients-by-age-at-diagnosis-a-population-based-cohort-study
#9
G M H E Dackus, K Jóźwiak, G S Sonke, E van der Wall, P J van Diest, M Hauptmann, S Siesling, S C Linn
BACKGROUND: Prior randomised controlled trials on adjuvant hormonal therapy included HER2any patients; however, a differential effect of aromatase inhibitors (AIs) versus tamoxifen (TAM) may have been missed in ER+/HER2+ patients that comprise 7-15% of all breast cancer patients. In addition, a woman's hormonal microenvironment may influence sensitivity to TAM and AIs in the adjuvant setting, which changes during menopausal transition, a process that takes years. We studied the efficacy of AIs versus TAM in ER+/HER2+ breast cancer patients grouped by age at diagnosis as a proxy for menopausal status using treatment and outcome data from the nationwide population-based Netherlands Cancer Registry (NCR)...
December 21, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29258952/5-aminolevulinic-acid-photodynamic-therapy-in-refractory-vulvar-lichen-sclerosus-et-atrophicus-series-of-ten-cases
#10
Ting Lan, Yongzhen Zou, Michael R Hamblin, Rui Yin
BACKGROUND: Vulvar lichen sclerosus et atrophicus (VLSA) is a chronic inflammatory skin disease of unknown etiology that mainly affects postmenopausal and perimenopausal women. The primary clinical symptoms of VLSA are itching, burning pain, and dyspareunia that can results in decreased quality of life. Existing therapies including topical corticosteroid ointment, topical calcineurin inhibitors, estrogens, are not very effective for treatment of VLSA. OBJECTIVE: To evaluate the effectiveness and safety of 5-aminolevulinic acid mediated photodynamic therapy (ALA-PDT) in the treatment of VLSA...
December 16, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29258873/perimenopausal-bone-histomorphometry-before-and-after-menopause
#11
Robert R Recker, Joan M Lappe, Michael Davies, Donald Kimmel
Investigators and clinicians have had few normal bone histomorphometry data available to compare with those found in diseased patients, or in the results of treatments. The Goals and Objectives of this work are two-fold: 1. to present static and dynamic bone histomorphometry data from transilial bone biopsies performed on 76 healthy, premenopausal women. 2. To present paired static and dynamic bone histomorphometry data from bone biopsies on a subset (N=51 pairs) of these same healthy women whose biopsies were repeated 12months after their last menses...
December 16, 2017: Bone
https://www.readbyqxmd.com/read/29240514/menopausal-asthma-much-ado-about-nothing-an-observational-study
#12
Katarzyna Bialek-Gosk, Marta Maskey-Warzechowska, Rafal Krenke, Marta Dabrowska, Magdalena Paplinska-Goryca, Patrycja Nejman-Gryz, Joanna Domagala-Kulawik, Tadeusz Przybylowski, Ryszarda Chazan
OBJECTIVE: Menopausal asthma is considered a distinct asthma phenotype. Our aim was to identify potential specific features of asthma in postmenopausal women in a cohort of Polish females. METHODS: Asthma severity and control, pulmonary function, exhaled nitric oxide (FENO), peripheral blood and induced sputum (IS) differential cell count were compared in three groups: women with premenopausal asthma (group 1), menopausal women with pre-existing asthma (group 2A) and menopausal women with asthma onset in the perimenopausal or menopausal period (group 2B)...
December 14, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29231589/-effects-of-moxibustion-at-shenshu-bl-23-on-level-of-sex-hormones-and-amh-in-sub-health-peri-menopausal-women
#13
Jie Shen, Meihong Shen, Zhongren Li, Rongli Zhang, Xia Li, Bingwei Ai
OBJECTIVE: To compare the effects between moxibustion at Shenshu (BL 23) and oral administration of Vitamin E on quality of life and mechanism in sub-health perimenopausal women, aiming to provide clinical evidence of moxibustion for health care of sub-health female. METHODS: Sixty participants were randomly divided into a moxibustion group and a medication group, 30 cases in each one. The volunteers in the moxibustion group were treated with mild moxibustion at bilateral Shenshu (BL 23) for 15 min, once a day; five treatments were considered as a course of treatment, and totally 4 courses were given with an interval of 2 days between courses...
April 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231429/-comparison-between-manual-acupuncture-and-electroacupuncture-for-hot-flashes-and-sex-hormone-of-perimenopausal-syndrome
#14
Zhiliang Cao, Jian Tang, Yuting Xue, Qiong Wang, Saiqun Li, Youjun Zhou, Wei Zhang
OBJECTIVE: To compare the effect and differences sex the influence of hormone levels of perimenopau-sal syndrome patients between manual acupuncture and electroacupuncture (EA). METHODS: A total of 50 cases with perimenopausal syndrome were randomly assigned into an manual acupuncture group (27 cases) and an EA group (23 cases), and 1 case dropped in the EA group. The acupoints in the two groups were Guanyuan (CV 4), Zigong (EX-CA 1), Tianshu (ST 25), and Sanyinjiao (SP 6)...
March 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29229752/ribociclib-extends-survival-in-hr-breast-cancer
#15
(no author information available yet)
Adding the CDK4/6 inhibitor ribociclib to standard first-line endocrine therapy significantly prolonged survival in premenopausal and perimenopausal women with advanced HR-positive, HER2-negative breast cancer enrolled in the MONALEESA-7 trial. This is the first definitive evidence that CDK4/6 inhibitor-based therapy is effective for first-line treatment of premenopausal and perimenopausal women.
December 11, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/29218931/-research-progress-in-phytoestrogens-of-traditional-chinese-medicine
#16
REVIEW
Yuan Zhao, Hong-Xia Zheng, Ying Xu, Na Lin
Phytoestrogens are plant-derived compounds, which have a similarity in structure with human endogenous estrogen 17-β-estradiol. Structural likeness enables phytoestrogens to interact with estrogen receptors, not simply mimicking the effects of human steroidal estrogen but also exhibiting similar and divergent actions. The global literature relating to phytoestrogen in recent years was systematically summarized in this paper. Chemical compositions of phytoestrogens were mainly flavonoids, coumarins, lignans, terpenoids, steroids, etc...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29218771/menopause-related-appendicular-bone-loss-is-mainly-cortical-and-results-in-increased-cortical-porosity
#17
Åshild Bjørnerem, Xiaofang Wang, Minh Bui, Ali Ghasem-Zadeh, John L Hopper, Roger Zebaze, Ego Seeman
After menopause, remodeling becomes unbalanced and rapid. Each of the many remodeling transactions deposits less bone than it resorbed, producing microstructural deterioration. Trabecular bone is said to be lost more rapidly than cortical bone. However, because 80% of the skeleton is cortical, we hypothesized that most menopause-related bone loss and changes in bone microstructure are cortical, not trabecular in origin, and are the result of intracortical remodeling. Distal tibial and distal radial microstructure were quantified during 3...
December 8, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29216870/prevalence-and-severity-of-menopause-symptoms-among-perimenopausal-and-postmenopausal-women-aged-30-49%C3%A2-years-in-gulele-sub-city-of-addis-ababa-ethiopia
#18
Engida Yisma, Natnael Eshetu, Stephanie Ly, Berhanu Dessalegn
BACKGROUND: Menopause is a natural phenomenon occurring as women approach middle-age. It is characterized by declining of ovarian function and onset of the last menstrual period and subsequent 12-month cessation of menstruation. Due to a growing aging population and longer life expectancies, sub-Saharan African women will spend a significant portion of their lives in postmenopause. Menopausal symptom research has been primarily conducted on Caucasian women from high-income countries. Understanding menopause symptom prevalence and perceptions among diverse women in Ethiopia will better inform reproductive health care...
December 8, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/29216853/obesity-associates-with-vasomotor-symptoms-in-postmenopause-but-with-physical-symptoms-in-perimenopause-a-cross-sectional-study
#19
Seul Koo, Younjhin Ahn, Joong-Yeon Lim, Juhee Cho, Hyun-Young Park
BACKGROUND: Middle-aged women experience various menopausal symptoms during the menopause. These symptoms can affect their quality of life and health. Several epidemiological studies reported that obesity associates with menopausal symptoms. The aim of this cross-sectional study was to examine the associations between obesity and multiple menopausal symptoms at different stages of menopause in middle-aged Korean women. METHODS: The study population included women aged 44-56 years who visited a tertiary referral hospital for medical check-ups between November 2012 and March 2013 and were free from serious illness, could comprehend a questionnaire...
December 8, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/29207728/the-effect-of-soy-isoflavones-on-the-menopause-rating-scale-scoring-in-perimenopausal-and-postmenopausal-women-a-pilot-study
#20
Marya Ahsan, Ayaz Khurram Mallick
Introduction: Menopause is associated with many unpleasant symptoms which vary in different phases of menopausal transition. Although, Hormone Replacement Therapy (HRT) is considered the most effective mode of treatment for these symptoms, its use is associated with increased risk of breast cancer, endometrial cancer and thromboembolic events. Soy isoflavones are being widely used as a safer alternative to HRT, even though scientific evidence of their efficacy is poor or lacking. Aim: To study the effect of soy isoflavone supplementation on the menopausal symptoms in perimenopausal and postmenopausal women...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
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