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https://www.readbyqxmd.com/read/28937311/it-s-not-as-bad-as-you-think-menopausal-representations-are-more-positive-in-postmenopausal-women
#1
Lydia Brown, Valerie Brown, Fiona Judd, Christina Bryant
INTRODUCTION: The menopausal transition is associated with underlying hormonal changes that can contribute to a range of physical and emotional symptoms. Psycho-social factors including attitudes and internal representations play a central role in women's experience of the menopause, but very little is known about how representations might differ across menopausal stages. METHODS: A sample of 387 women aged 40-60 completed a postal questionnaire that included the menopausal representations questionnaire, the emotional representation subscale adapted from the illness perception questionnaire, and data on menopausal status...
September 22, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28926513/pharmacokinetics-and-safety-profile-of-single-dose-administration-of-an-estrogen-receptor-%C3%AE-selective-phytoestrogenic-phytoserm-formulation-in-perimenopausal-and-postmenopausal-women
#2
Gerson Hernandez, Liqin Zhao, Adrian A Franke, Yu-Ling Chen, Wendy J Mack, Roberta D Brinton, Lon S Schneider
OBJECTIVE: Selected estrogen receptor β-selective phytoestrogen (phytoSERM), a preparation of genistein, daidzein, and S-equol, has an 83-fold selective affinity for estrogen receptor (ER) β, and may promote neuronal survival and estrogenic mechanisms in the brain without exerting feminizing activity in the periphery. The aim of this study was to assess the safety, tolerability, and single-dose pharmacokinetics of the phytoSERM formulation in perimenopausal and postmenopausal women...
September 18, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28922102/sleep-duration-and-quality-among-women-aged-40-59-by-menopausal-status
#3
Anjel Vahratian
Data from the National Health Interview Survey, 2015 ? Among those aged 40?59, perimenopausal women (56.0%) were more likely than postmenopausal (40.5%) and premenopausal (32.5%) women to sleep less than 7 hours, on average, in a 24-hour period. ? Postmenopausal women aged 40?59 were more likely than premenopausal women aged 40?59 to have trouble falling asleep (27.1% compared with 16.8%, respectively), and staying asleep (35.9% compared with 23.7%), four times or more in the past week. ? Postmenopausal women aged 40?59 (55...
September 2017: NCHS Data Brief
https://www.readbyqxmd.com/read/28914851/-oxidative-stress-in-women-with-insomnia-in-different-stages-of-menopause
#4
L I Kolesnikova, N V Semenova, E I Solodova, I M Madaeva
AIM: To investigate of a lipid peroxidation (LPO) process and the antioxidant defense system (ADS) in peri- and postmenopausal women with insomnia. SUBJECTS AND METHODS: 47 perimenopausal women and 71 postmenopausal ones were examined. Each group was divided into 2 subgroups: 1) individuals with insomnia and 2) controls. LPO-ADS spectrophotometric studies were used in the investigation. RESULTS: There was an increase in the serum levels of ketodienes and conjugated trienes and a decrease in those of α-tocopherol and retinol in postmenopause versus in perimenopause...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28914672/endometrial-changes-in-surgical-specimens-of-perimenopausal-patients-treated-with-ulipristal-acetate-for-uterine-leiomyomas
#5
Francisco F Nogales, Vicente Crespo-Lora, Nelly Cruz-Viruel, Clara Chamorro-Santos, Christine Bergeron
Ulipristal acetate (UPA) is used to treat leiomyomas, and its effect on the endometrium has been studied in biopsy material. Reversible histologic modifications were found, named progesterone receptor modulators-associated endometrial changes (PAEC). However, hysterectomies from patients treated with UPA have not been analyzed. For the first time, we examined surgical specimens from 100 leiomyoma-treated patients for UPA-related endometrial changes. We analyzed the distribution of lesions, involution after treatment, and the relationship between type and extent of lesions and dosage...
September 13, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28905347/-mixed-epithelial-and-stromal-tumour-of-the-kidney-a-case-report
#6
G Brüwer, C M Naumann, M V Petersdorff, K Jünemann, D Osmonov
Mixed epithelial and stromal tumours of the kidney are rare. Histologically, they are characterised by a complex of epithelium and stroma with cystic and solid areas. They usually occur in perimenopausal women receiving hormone replacement with oestrogen. Typical symptoms are haematuria, flank pain and a palpable mass, with more and more authors reporting incidentally diagnosed tumours. This also applies to our case report. We are reporting the first published case in Germany: a 60-year-old female with a mixed epithelial and stromal tumour of the right kidney...
September 13, 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28904082/a-relative-l-arginine-deficiency-contributes-to-endothelial-dysfunction-across-the-stages-of-the-menopausal-transition
#7
Jelena Klawitter, Kerry L Hildreth, Uwe Christians, Wendy M Kohrt, Kerrie L Moreau
Vascular endothelial function declines across the menopause transition in women. We tested the hypothesis that reduced availability of the endothelial nitric oxide synthase [eNOS] substrate L-arginine is an underlying mechanism to vascular endothelial dysfunction across menopause stages. Endothelial function (brachial artery flow-mediated dilation [FMD]) and plasma markers of L-arginine metabolism (citrulline, N(G)-mono-methyl-ւ-arginine [L-NMMA] asymmetric dimethylarginine [ADMA] and N(G)-N('G)-dimethyl-l-arginine [SDMA]), were measured in 129 women: 36 premenopausal (33 ± 7 years), 16 early- (49 ± 3 years) or 21 late- (50 ± 4 years) perimenopausal, and 21 early- (55 ± 3 years) or 35 late- (61 ± 4 years) postmenopausal...
September 2017: Physiological Reports
https://www.readbyqxmd.com/read/28903474/nitric-oxide-heat-shock-protein-axis-in-menopausal-hot-flushes-neglected-metabolic-issues-of-chronic-inflammatory-diseases-associated-with-deranged-heat-shock-response
#8
Antônio Azambuja Miragem, Paulo Ivo Homem de Bittencourt
BACKGROUND: Although some unequivocal underlying mechanisms of menopausal hot flushes have been demonstrated in animal models, the paucity of similar approaches in humans impedes further mechanistic outcomes. Human studies might show some as yet unexpected physiological mechanisms of metabolic adaptation that permeate the phase of decreased oestrogen levels in both symptomatic and asymptomatic women. This is particularly relevant because both the severity and time span of hot flushes are associated with increased risk of chronic inflammatory disease...
September 1, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28894392/fractional-co2-laser-treatment-for-vulvovaginal-atrophy-symptoms-and-vaginal-rejuvenation-in-perimenopausal-women
#9
César Arroyo
BACKGROUND: This study investigated a novel fractional carbon dioxide (CO2) laser for treatment of symptoms associated with vulvovaginal atrophy (VVA) in perimenopausal women. METHODS: The study included 21 perimenopausal women (mean age 45±7 years) treated three times by CO2 laser resurfacing and coagulation of the vaginal canal tissue and mucosal tissue of the introitus. Vaginal health index (VHI) scores were computed by the investigator at baseline and follow-ups...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28886339/longitudinal-study-of-insomnia-symptoms-among-women-during-perimenopause
#10
Colleen Ciano, Tonya S King, Robin Redmon Wright, Michael Perlis, Amy M Sawyer
OBJECTIVE: To describe the prevalence of insomnia symptoms among women during perimenopause and to examine differences in self-reported insomnia symptoms at different stages of perimenopause over 10 years. DESIGN: Secondary analysis of self-reported sleep symptoms and clinical variables using 10 years of publicly available data from the Study of Women Across the Nation (SWAN). SETTING: The data set of women's insomnia symptoms was obtained from publicly available data from the SWAN...
September 5, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/28885410/distressing-sexual-function-at-midlife-unmet-needs-practical-diagnoses-and-available-treatments
#11
James A Simon, Vanessa A Lukas
Female sexual dysfunction (FSD) is characterized as chronic sexual symptoms that manifest with personal distress in the domains of desire, arousal, orgasm, and pain. Extensive epidemiologic evidence estimates that almost 50% of perimenopausal and postmenopausal women experience FSD. Screening for FSD is not readily conducted and patient-physician discussion of sexuality is limited by the lack of physician training on the topic and by the patient-held belief that sexual issues are not medical in nature. The purpose of this commentary is to provide clinicians with a framework to approach the discussion of FSD, to clinically identify FSD through patient symptoms and physical signs, and to manage FSD in perimenopausal and postmenopausal patients with the available U...
September 5, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28883860/impact-of-beverage-consumption-age-and-site-dependency-on-dual-energy-x-ray-absorptiometry-dexa-measurements-in-perimenopausal-women-a-prospective-study
#12
Huan-Chu Lo, Duen-Pang Kuo, Yen-Lin Chen
INTRODUCTION: The aim of this study was to determine the best site for bone mineral density (BMD) measurements based on T-scores, age, and beverage consumption. MATERIAL AND METHODS: In this prospective study, 271 women stratified by age (average age: 61.9 years) underwent dual energy X-ray absorptiometry (DEXA) scanning of their lumbar spine, hips, and forearms. Osteoporosis was defined as a BMD of 2.5 standard deviations or more below the mean peak bone mass based on a reference population of adult women (translated as a T-score ≤ -2...
August 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28879661/survival-of-cutaneous-melanoma-based-on-sex-age-and-stage-in-the-united-states-1992-2011
#13
Elizabeth Ann L Enninga, Justin C Moser, Amy L Weaver, Svetomir N Markovic, Jerry D Brewer, Alexey A Leontovich, Tina J Hieken, Lynne Shuster, Lisa A Kottschade, Ariadna Olariu, Aaron S Mansfield, Roxana S Dronca
Women diagnosed with cutaneous melanoma have a survival advantage compared to men, which has been hypothesized to be due to difference in behavior and/or biology (sex hormones). It remains controversial whether this advantage is dependent on age or stage of disease. We sought to compare melanoma-specific survival between females in pre, peri, and postmenopausal age groups to males in the same age group, adjusting for stage of disease. This is a retrospective population-based cohort study using the Surveillance, Epidemiology, and End Results (SEER) database...
September 6, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28871713/cognitive-functions-and-serum-cortisol-concentration-in-perimenopausal-and-postmenopausal-women-working-non-manually
#14
Dorota Raczkiewicz, Beata Sarecka-Hujar, Alfred Owoc, Iwona Bojar
OBJECTIVES: To asses a possible relationship between serum cortisol concentration and cognitive function in peri- and postmenopausal women engaging in non-manual work. METHODS: The Montreal Cognitive Assessment (MoCA) was used to screen women for the study and the Computerized Neurocognitive-assessment Software (CNS) Vital Signs to diagnose cognitive functions. RESULTS: Cognitive functions and serum cortisol concentration did not differ between women in early and late perimenopause and postmenopause...
August 5, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28862661/the-effect-of-taichi-practice-on-attenuating-bone-mineral-density-loss-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#15
REVIEW
Liye Zou, Chaoyi Wang, Kevin Chen, Yankai Shu, Xiaoan Chen, Lin Luo, Xitang Zhao
Objective: The purpose of this study was to determine the effects of practicing Taichi on attenuating bone mineral density (BMD) loss. Methods: Both electronic and manual searches were performed for randomized controlled trials (RCTs) examining Taichi for bone health. Two review authors independently performed study selection and data extraction according to inclusion criteria. A third party (Lin Luo) emerged to discuss with the two review authors and resolve a disagreement. Results: Twenty RCTs were found to meet the inclusion criteria and used for meta-analysis with a total effective sample of 1604...
September 1, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28858028/prevalence-of-sexual-symptoms-in-relation-to-menopause-in-women-in-asia-a-systematic-review
#16
Rakibul M Islam, Robin J Bell, Susan R Davis
OBJECTIVE: This systematic review of the literature was undertaken to investigate the prevalence of sexual symptoms in women in Asia in relation to their menopause status. METHODS: MEDLINE, EMBASE, PsycINFO, CINAHL, SCOPUS, and Google scholar were searched systematically for relevant population-based prevalence studies published between 1988 and 2016. The included studies were assessed for risk of bias using a risk-of-bias tool developed explicitly for the systematic review of prevalence studies...
August 28, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28855400/sex-differences-in-alzheimer-risk-brain-imaging-of-endocrine-vs-chronologic-aging
#17
Lisa Mosconi, Valentina Berti, Crystal Quinn, Pauline McHugh, Gabriella Petrongolo, Isabella Varsavsky, Ricardo S Osorio, Alberto Pupi, Shankar Vallabhajosula, Richard S Isaacson, Mony J de Leon, Roberta Diaz Brinton
OBJECTIVE: This observational multimodality brain imaging study investigates emergence of endophenotypes of late-onset Alzheimer disease (AD) risk during endocrine transition states in a cohort of clinically and cognitively normal women and age-matched men. METHODS: Forty-two 40- to 60-year-old cognitively normal women (15 asymptomatic perimenopausal by age [CNT], 13 perimenopausal [PERI], and 14 postmenopausal [MENO]) and 18 age- and education-matched men were examined...
August 30, 2017: Neurology
https://www.readbyqxmd.com/read/28852842/the-impact-of-combined-nutraceutical-supplementation-on-quality-of-life-and-metabolic-changes-during-the-menopausal-transition-a-pilot-randomized-trial
#18
Paola Villa, Inbal D Amar, Carolina Bottoni, Clelia Cipolla, Giorgia Dinoi, Maria C Moruzzi, Giovanni Scambia, Antonio Lanzone
PURPOSE: The aim of this study was to assess the efficacy of a combined nutraceutical supplement on symptoms and early metabolic alterations during the menopausal transition. This pilot randomized study was conducted at the service for menopause disorders of the Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Rome, Italy. METHODS: Ninety women in menopausal transition who attended our service with menopausal symptoms were enrolled in the study...
August 29, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28832483/clinical-updates-in-women-s-health-care-summary-mood-and-anxiety-disorders-primary-and-preventive-care-review
#19
REVIEW
Lauren M Osborne, Jennifer L Payne
The management of psychiatric disorders in women is complicated by reproductive life cycle events. Psychiatric disorders can be initiated or exacerbated during times of hormonal change (such as menarche, the premenstrual period, the postpartum period, and perimenopause), and during the childbearing years, treatment is complicated by pregnancy and breastfeeding. These issues make determining the appropriate psychiatric medications to use in the treatment of mood and anxiety disorders in women complex. This monograph addresses practical approaches in the provision of thorough and individualized care for women with mood or anxiety disorders...
September 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28825955/epidemiology-and-treatment-of-eating-disorders-in-men-and-women-of-middle-and-older-age
#20
Barbara Mangweth-Matzek, Hans W Hoek
PURPOSE OF REVIEW: We summarized recent literature on the epidemiology and treatment of eating disorders in middle-aged and older women and men. RECENT FINDINGS: The prevalence of eating disorders according to DSM-5 criteria is around 3.5% in older (>40 years) women and around 1-2% in older men. The majority of those eating disordered persons are not in treatment. There are new terms like 'perimenopausal eating disorders' and 'muscularity-oriented eating disorders' indicating the impact of the aging process and sex-specific differences...
August 18, 2017: Current Opinion in Psychiatry
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