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https://www.readbyqxmd.com/read/28724213/characterization-of-serum-estradiol-level-and-tissue-estrogen-receptor-immunostaining-with-clinical-response-and-reproductive-factor-changes-in-chinese-female-patients-with-esophageal-squamous-cell-carcinoma
#1
Dongyun Zhang, Jianwei Ku, Ran Liu, Hongfang Wu, Guina Liang, Yan Wei, Peinan Chen, Xueke Zhao, Song Liu, Yin Li, Jianchao Yao, Xin Song, Lidong Wang
Pre-menopausal female patients have a prolonged survival than post-menopausal patients, indicating that estrogen and/or estrogen receptor (ER) may have some biological effects on prognosis. ER expression in cancer tissue has been reported to be a significant prognostic marker in multiple human cancers. However, the prognostic value of estrogen and/or ER on female patients with esophageal squamous cell carcinoma (ESCC) is rarely reported. The present study was undertaken to elucidate the associations of serum estradiol level, tissue estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) expression with clinical response and reproductive factor changes in 387 female ESCC patients...
July 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28686649/survey-on-the-levels-of-25-hydroxy-vitamin-d-and-bone-metabolic-markers-and-evaluation-of-their-correlations-with-osteoporosis-in-perimenopausal-woman-in-xi-an-region
#2
Ping Zhou, Jian Hu, Ping Xi, Ning Zhang, Bo Yang, Jie Zheng, Xiaoqin Wang
It has been accepted that vitamin D (VD) plays an important role in bone metabolism. However, the levels of VD in people of different regions are quite different and there is still no final conclusion on the significant correlation between VD and osteoporosis. 245 cases of peri-menopausal women were collected to study the relationship between VD and osteoporosis in western China. The mean value of 25-hydroxyvitamin D for the participants was 14.39 ng/mL. The average values of parathyroid hormone (PTH), calcium (Ca) and phosphorus (P) were 47...
2017: PloS One
https://www.readbyqxmd.com/read/28639461/hormonal-contraception-and-breast-cancer-what-more-do-we-need-to-know
#3
Jo Marsden
Most women use hormonal contraception for more than 30 years and for many, this may involve exposure in their older reproductive years when baseline breast cancer risk rises steeply. Overall, the risk of breast cancer diagnosis with exposure to hormonal contraception is very small and outweighed by its contraceptive benefits but despite this, there are still outstanding questions for all methods used in clinical practice due to paucity of available evidence, lack of which should not be taken to imply safety...
January 1, 2017: Post Reproductive Health
https://www.readbyqxmd.com/read/28591133/combined-red-clover-isoflavones-and-probiotics-potently-reduce-menopausal-vasomotor-symptoms
#4
Max Norman Tandrup Lambert, Anne Cathrine Thorup, Esben Søvsø Szoscka Hansen, Per Bendix Jeppesen
BACKGROUND: Natural estrogen decline leads to vasomotor symptoms (VMS). Hormone therapy alleviates symptoms but increases cancer risk. Effective treatments against VMS with minimal cancer risks are needed. We investigate the effects of a highly bioavailable aglycone rich Red Clover isoflavone treatment to alleviate existing menopausal VMS, assessed for the first time by 24hour ambulatory skin conductance (SC). METHODS AND RESULTS: We conducted a parallel, double blind, randomised control trial of 62 peri-menopausal women aged 40-65, reporting ≥ 5 hot flushes/day and follicle stimulating hormone ≥35 IU/L...
2017: PloS One
https://www.readbyqxmd.com/read/28584316/stress-at-the-place-of-work-and-cognitive-functions-among-women-performing-intellectual-work-during-peri-and-post-menopausal-period
#5
Mariusz Gujski, Jarosław Pinkas, Tomasz Juńczyk, Adrianna Pawełczak-Barszczowska, Dorota Raczkiewicz, Alfred Owoc, Iwona Bojar
OBJECTIVES: The analysis of the relationship between stress at work and results of cognitive functions amongst women, at peri- and post-menopausal age, performing intellectual work. MATERIAL AND METHODS: The study group included women, aged 45-66 years old, employed as intellectual workers. Research instruments were: the Montreal Cognitive Assessment; computer tests of the CNS Vital Signs; the Subjective Work Characteristics Questionnaire, and a questionnaire designed by the author...
March 27, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28551920/-women-s-cardiac-health-from-theory-to-activism
#6
REVIEW
Avital Porter
Cardiovascular disease (CVD) is the leading cause of death in the western world, in both genders. Although awareness of the importance of prevention, diagnosis and optimal treatment of CVD has risen in general, most women are not fully aware of their CVD risk. Moreover, women are not alert to the burden of risk in their reproductive years (e.g. complicated pregnancy and/or peri-menopausal period) and their impact on future CVD. Unique Female issues such as: fertile age, menopause, oral contraceptives, hormonal and metabolic disorders during pregnancy, labor, as well as psychological matters, and healthy life-style are major contributors to primary and secondary prevention of CVD...
April 2017: Harefuah
https://www.readbyqxmd.com/read/28532219/no-sweat-managing-menopausal-symptoms-at-work
#7
Martha Hickey, Kathleen Riach, Reza Kachouie, Gavin Jack
INTRODUCTION: Menopause usually occurs between the ages of 45 and 55, a time when women are likely to be in the paid workforce. Most women have menopausal symptoms and these may impact on daytime function and work performance. This study examines the relationship between reproductive stage, menopausal symptoms and work, and advises how employers can best support menopausal women. METHODS: An online and paper-based survey was completed in 2015-16 by 1092 women (22% response rate) aged 40 years plus employed in three hospitals in metropolitan Australia...
May 22, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28499900/lurasidone-in-post-menopausal-females-with-major-depressive-disorder-with-mixed-features-post-hoc-analysis-of-a-placebo-controlled-trial
#8
John Sramek, Antony Loebel, Michael Murphy, Yongcai Mao, Andrei Pikalov, Neal R Cutler
BACKGROUND: Several studies have found that depressed, post-menopausal females may respond differently to antidepressants compared to pre-menopausal females. The atypical antipsychotic lurasidone, whose mechanism of action differs from SSRIs and other standard antidepressants, was shown in a 6-week randomized, flexible-dose, placebo-controlled study (n=209), to be effective in treating major depressive disorder (MDD) with mixed features (subthreshold hypomanic symptoms). This post-hoc analysis assessed the efficacy of lurasidone in this study by menopausal status...
May 9, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28458476/quality-of-life-among-menopausal-women-a-community-based-study-in-a-rural-area-of-west-bengal
#9
Nabarun Karmakar, Somak Majumdar, Aparajita Dasgupta, Sulagna Das
INTRODUCTION: During menopausal transition, there is a lot of fluctuation in the hormone levels making the peri and postmenopausal women susceptible to various mental and physical disorders. There is considerably lack of awareness about the effects of the menopausal symptoms in women in India. Studies on issues relating to menopause, especially among rural women, are also lacking. With this background, the current study was carried out in a rural area of West Bengal with the objective to assess the quality of life (QOL) of peri-menopausal women...
January 2017: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28364866/being-overweight-or-obese-is-associated-with-harboring-a-gut-microbial-community-not-capable-of-metabolizing-the-soy-isoflavone-daidzein-to-o-desmethylangolensin-in-peri-and-post-menopausal-women
#10
Lindsey M Miller, Johanna W Lampe, Katherine M Newton, Gabrielle Gundersen, Sharon Fuller, Susan D Reed, Cara L Frankenfeld
OBJECTIVE: Obesity can be a considerable health concern for peri- and post-menopausal women. Evidence suggests an association between the gut microbiome and obesity. The study objective was to evaluate the association between being overweight or obese and phenotypic markers of having an overall gut microbial environment not capable of metabolizing the isoflavone daidzein to equol or O-desmethylangolensin (ODMA). STUDY DESIGN: Cross-sectional study of 137 peri- and 218 post-menopausal women, aged 44-55 years, who consumed at least three servings per week of soy (source of daidzein)...
May 2017: Maturitas
https://www.readbyqxmd.com/read/28278011/evaluation-of-trait-and-state-anxiety-levels-in-a-group-of-peri-and-postmenopausal-women
#11
Mónica Flores-Ramos PhD, Roberto Silvestri Tomassoni, José Benjamín Guerrero-López, Margus Salinas
Our objective was to evaluate levels of trait and state anxiety in a group of peri- and postmenopausal women and to explore the relation of hormonal therapy to levels of anxiety. Peri- (n = 63) and postmenopausal (n = 236) women were evaluated between March and September 2013. The assessed variables were menopausal status, anxiety (using the state and trait anxiety inventory), and sociodemographic and clinical variables. Use of psychotropic medications and hormone therapy was also ascertained. The mean age of the participants was 51...
February 16, 2017: Women & Health
https://www.readbyqxmd.com/read/28116886/normalization-of-cardiovascular-risk-factors-in-peri-menopausal-women-with-pycnogenol%C3%A2
#12
Roberta Luzzi, Gianni Belcaro, Morio Hosoi, Beatrice Feragalli, Umberto Cornelli, Mark Dugall, Andrea Ledda
BACKGROUND: The aim of the study was the evaluation of the efficacy of Pycnogenol® in peri-menopausal women in controlling homocysteine and C-reactive protein (CRP) levels, borderline cardiovascular risk factors, oxidative stress (OS) and symptoms associated to menopausal transition (MT). METHODS: Pycnogenol®, 100mg/day, was used as a supplement for 8 weeks by a group of 35 women. A comparable group of 35 women with identical cardiovascular risk factors was included as the control group...
February 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28074250/cortical-porosity-exhibits-accelerated-rate-of-change-in-peri-compared-with-post-menopausal-women
#13
L A Burt, J L Bhatla, D A Hanley, S K Boyd
The rate of change in bone density was not different between peri- and post-menopausal women. Differences in rate of change were observed in bone microarchitecture, specifically cortical porosity (Ct.Po), where peri-menopausal women increased +9% per year compared with the +6% per year for post-menopausal women. INTRODUCTION: The purpose of this study was to compare changes in bone density and microarchitecture in peri- and post-menopausal women over 6 years. METHODS: Peri- (n = 26) and post- (n = 65) menopausal women were selected from the Canadian Multicenter Osteoporosis Study...
January 10, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28030937/predictors-of-the-quality-of-life-of-women-in-peri-menopausal-period
#14
Katarzyna Kanadys, Anna Wiktor-Stoma, Magdalena Lewicka, Magdalena Sulima, Henryk Wiktor
INTRODUCTION: The peri-menopausal period is the time of many biological, psychological and social changes. The quality of life of women in this period may be conditioned by many factors, and analysis of these factors may indicate the optimum directions of prophylactic and educational actions. OBJECTIVE: Analysis of selected predictive factors of the quality of life of women in the peri-menopausal period. MATERIALS AND METHOD: The study covered 268 peri-menopausal women...
December 23, 2016: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/27920066/new-concepts-for-an-old-problem-the-diagnosis-of-endometrial-hyperplasia
#15
Peter A Sanderson, Hilary O D Critchley, Alistair R W Williams, Mark J Arends, Philippa T K Saunders
BACKGROUND: Endometrial hyperplasia (EH) is a uterine pathology representing a spectrum of morphological endometrial alterations. It is predominantly characterized by an increase in the endometrial gland-to-stroma ratio when compared to normal proliferative endometrium. The clinical significance of EH lies in the associated risk of progression to endometrioid endometrial cancer (EC) and 'atypical' forms of EH are regarded as premalignant lesions. Traditional histopathological classification systems for EH exhibit wide and varying degrees of diagnostic reproducibility and, as a consequence, standardized patient management can be challenging...
March 1, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/27845510/outcomes-of-monopolar-versus-bipolar-endometrial-ablation-on-uterine-bleeding-and-psychophysical-wellbeing
#16
Pasquale De Franciscis, Flavio Grauso, Luigi Cobellis, Enrico M Messalli, Gaspare Cucinella, Antonino Perino, Nicola Colacurci, Marco Torella
PURPOSE: to compare outcomes of endometrial ablation with monopolar versus bipolar resection on uterine bleeding and psychophysical wellbeing. METHODS: In a prospective randomized study, 100 peri-menopausal patients, without desire of pregnancy and with no response to pharmacological treatment, underwent endometrial ablation from 2012 to 2014. They were randomly divided in two groups: 50 patients treated with monopolar electrode resection loop (group A) and 50 patients treated with bipolar electrode resection loop (group B)...
November 15, 2016: Minerva Ginecologica
https://www.readbyqxmd.com/read/27821168/associations-of-proteins-relevant-to-mapk-signaling-pathway-p38mapk-1-hif-1-and-ho-1-with-coronary-lesion-characteristics-and-prognosis-of-peri-menopausal-women
#17
Liqiu Yan, Xufen Cao, Saitian Zeng, Zhe Li, Zheng Lian, Jiawang Wang, Fengfeng Lv, Yunfei Wang, Yanshen Li
BACKGROUND: The present study was intended to explore whether three proteins within MAPK signaling pathway (i.e. p38MAPK-1, HIF-1 and HO-1) were correlated with peri-menopausal women's coronary lesion features and prognosis. METHODS: Altogether 1449 peri-menopausal women were divided into non-coronary artery disease (CAD) group (n = 860) and CAD group (n = 589), including 167 pre-menopausal CAD populations and 422 post-menopausal CAD populations. General information about CAD risk parameters were gathered, including age, family history of CAD or hypertension or diabetes mellitus, bilirubin, cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) and so on...
November 8, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27621257/the-interlace-study-design-data-harmonization-and-characteristics-across-20-studies-on-women-s-health
#18
Gita D Mishra, Hsin-Fang Chung, Nirmala Pandeya, Annette J Dobson, Lee Jones, Nancy E Avis, Sybil L Crawford, Ellen B Gold, Daniel Brown, Lynette L Sievert, Eric Brunner, Janet E Cade, Victoria J Burley, Darren C Greenwood, Graham G Giles, Fiona Bruinsma, Alissa Goodman, Kunihiko Hayashi, Jung Su Lee, Hideki Mizunuma, Diana Kuh, Rachel Cooper, Rebecca Hardy, Carla Makhlouf Obermeyer, Kathryn A Lee, Mette Kildevæld Simonsen, Toyoko Yoshizawa, Nancy F Woods, Ellen S Mitchell, Mark Hamer, Panayotes Demakakos, Sven Sandin, Hans-Olov Adami, Elisabete Weiderpass, Debra Anderson
OBJECTIVES: The International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease Events (InterLACE) project is a global research collaboration that aims to advance understanding of women's reproductive health in relation to chronic disease risk by pooling individual participant data from several cohort and cross-sectional studies. The aim of this paper is to describe the characteristics of contributing studies and to present the distribution of demographic and reproductive factors and chronic disease outcomes in InterLACE...
October 2016: Maturitas
https://www.readbyqxmd.com/read/27506466/menopause-induced-uterine-epithelium-atrophy-results-from-arachidonic-acid-prostaglandin-e2-axis-inhibition-mediated-autophagic-cell-death
#19
Shengtao Zhou, Linjie Zhao, Tao Yi, Yuquan Wei, Xia Zhao
Women experience menopause later in life. Menopause is characterized by dramatically decreased circulating estrogen level secondary to loss of ovarian function and atrophic state of genital organs. However, the molecular mechanisms for this process are not fully understood. In this study, we aimed to investigate the potential molecular mechanisms that underlie menopause-induced uterine endometrial atrophy. Our data showed that autophagy was activated in the uterine epithelial cells of both ovariectomized rats and peri-menopausal females...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27294327/triglyceride-levels-and-fracture-risk-in-midlife-women-study-of-women-s-health-across-the-nation-swan
#20
MULTICENTER STUDY
Po-Yin Chang, Ellen B Gold, Jane A Cauley, Wesley O Johnson, Carrie Karvonen-Gutierrez, Elizabeth A Jackson, Kristine M Ruppert, Jennifer S Lee
CONTEXT: Unfavorable lipid levels contribute to cardiovascular disease and may also harm bone health. OBJECTIVE: Our objective was to investigate relationships between fasting plasma lipid levels and incident fracture in midlife women undergoing the menopausal transition. DESIGN AND SETTING: This was a 13-year prospective, longitudinal study of multiethnic women in five US communities, with near-annual assessments. PARTICIPANTS: At baseline, 2062 premenopausal or early perimenopausal women who had no history of fracture were included...
September 2016: Journal of Clinical Endocrinology and Metabolism
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