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https://www.readbyqxmd.com/read/28499900/lurasidone-in-post-menopausal-females-with-major-depressive-disorder-with-mixed-features-post-hoc-analysis-of-a-placebo-controlled-trial
#1
John Sramek, Anthony Loebel, Michael Murphy, Yongcai Mao, Andrei Pikalov, Neal R Cutler
BACKGROUND: Several studies have found that depressed, post-menopausal females may respond differently to antidepressants compared to pre-menopausal females. The atypical antipsychotic lurasidone, whose mechanism of action differs from SSRIs and other standard antidepressants, was shown in a 6-week randomized, flexible-dose, placebo-controlled study (n=209), to be effective in treating major depressive disorder (MDD) with mixed features (subthreshold hypomanic symptoms). This post-hoc analysis assessed the efficacy of lurasidone in this study by menopausal status...
May 9, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28458476/quality-of-life-among-menopausal-women-a-community-based-study-in-a-rural-area-of-west-bengal
#2
Nabarun Karmakar, Somak Majumdar, Aparajita Dasgupta, Sulagna Das
INTRODUCTION: During menopausal transition, there is a lot of fluctuation in the hormone levels making the peri and postmenopausal women susceptible to various mental and physical disorders. There is considerably lack of awareness about the effects of the menopausal symptoms in women in India. Studies on issues relating to menopause, especially among rural women, are also lacking. With this background, the current study was carried out in a rural area of West Bengal with the objective to assess the quality of life (QOL) of peri-menopausal women...
January 2017: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28364866/being-overweight-or-obese-is-associated-with-harboring-a-gut-microbial-community-not-capable-of-metabolizing-the-soy-isoflavone-daidzein-to-o-desmethylangolensin-in-peri-and-post-menopausal-women
#3
Lindsey M Miller, Johanna W Lampe, Katherine M Newton, Gabrielle Gundersen, Sharon Fuller, Susan D Reed, Cara L Frankenfeld
OBJECTIVE: Obesity can be a considerable health concern for peri- and post-menopausal women. Evidence suggests an association between the gut microbiome and obesity. The study objective was to evaluate the association between being overweight or obese and phenotypic markers of having an overall gut microbial environment not capable of metabolizing the isoflavone daidzein to equol or O-desmethylangolensin (ODMA). STUDY DESIGN: Cross-sectional study of 137 peri- and 218 post-menopausal women, aged 44-55 years, who consumed at least three servings per week of soy (source of daidzein)...
May 2017: Maturitas
https://www.readbyqxmd.com/read/28278011/evaluation-of-trait-and-state-anxiety-levels-in-a-group-of-peri-and-postmenopausal-women
#4
Mónica Flores-Ramos PhD, Roberto Silvestri Tomassoni, José Benjamín Guerrero-López, Margus Salinas
Our objective was to evaluate levels of trait and state anxiety in a group of peri- and postmenopausal women and to explore the relation of hormonal therapy to levels of anxiety. Peri- (n = 63) and postmenopausal (n = 236) women were evaluated between March and September 2013. The assessed variables were menopausal status, anxiety (using the state and trait anxiety inventory), and sociodemographic and clinical variables. Use of psychotropic medications and hormone therapy was also ascertained. The mean age of the participants was 51...
February 16, 2017: Women & Health
https://www.readbyqxmd.com/read/28116886/normalization-of-cardiovascular-risk-factors-in-peri-menopausal-women-with-pycnogenol%C3%A2
#5
Roberta Luzzi, Gianni Belcaro, Morio Hosoi, Beatrice Feragalli, Umberto Cornelli, Mark Dugall, Andrea Ledda
BACKGROUND: The aim of the study was the evaluation of the efficacy of Pycnogenol® in peri-menopausal women in controlling homocysteine and C-reactive protein (CRP) levels, borderline cardiovascular risk factors, oxidative stress (OS) and symptoms associated to menopausal transition (MT). METHODS: Pycnogenol®, 100mg/day, was used as a supplement for 8 weeks by a group of 35 women. A comparable group of 35 women with identical cardiovascular risk factors was included as the control group...
February 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28074250/cortical-porosity-exhibits-accelerated-rate-of-change-in-peri-compared-with-post-menopausal-women
#6
L A Burt, J L Bhatla, D A Hanley, S K Boyd
The rate of change in bone density was not different between peri- and post-menopausal women. Differences in rate of change were observed in bone microarchitecture, specifically cortical porosity (Ct.Po), where peri-menopausal women increased +9% per year compared with the +6% per year for post-menopausal women. INTRODUCTION: The purpose of this study was to compare changes in bone density and microarchitecture in peri- and post-menopausal women over 6 years. METHODS: Peri- (n = 26) and post- (n = 65) menopausal women were selected from the Canadian Multicenter Osteoporosis Study...
January 10, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28030937/predictors-of-the-quality-of-life-of-women-in-peri-menopausal-period
#7
Katarzyna Kanadys, Anna Wiktor-Stoma, Magdalena Lewicka, Magdalena Sulima, Henryk Wiktor
INTRODUCTION: The peri-menopausal period is the time of many biological, psychological and social changes. The quality of life of women in this period may be conditioned by many factors, and analysis of these factors may indicate the optimum directions of prophylactic and educational actions. OBJECTIVE: Analysis of selected predictive factors of the quality of life of women in the peri-menopausal period. MATERIALS AND METHOD: The study covered 268 peri-menopausal women...
December 23, 2016: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/27920066/new-concepts-for-an-old-problem-the-diagnosis-of-endometrial-hyperplasia
#8
Peter A Sanderson, Hilary O D Critchley, Alistair R W Williams, Mark J Arends, Philippa T K Saunders
BACKGROUND: Endometrial hyperplasia (EH) is a uterine pathology representing a spectrum of morphological endometrial alterations. It is predominantly characterized by an increase in the endometrial gland-to-stroma ratio when compared to normal proliferative endometrium. The clinical significance of EH lies in the associated risk of progression to endometrioid endometrial cancer (EC) and 'atypical' forms of EH are regarded as premalignant lesions. Traditional histopathological classification systems for EH exhibit wide and varying degrees of diagnostic reproducibility and, as a consequence, standardized patient management can be challenging...
March 1, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/27845510/outcomes-of-monopolar-versus-bipolar-endometrial-ablation-on-uterine-bleeding-and-psychophysical-wellbeing
#9
Pasquale De Franciscis, Flavio Grauso, Luigi Cobellis, Enrico M Messalli, Gaspare Cucinella, Antonino Perino, Nicola Colacurci, Marco Torella
PURPOSE: to compare outcomes of endometrial ablation with monopolar versus bipolar resection on uterine bleeding and psychophysical wellbeing. METHODS: In a prospective randomized study, 100 peri-menopausal patients, without desire of pregnancy and with no response to pharmacological treatment, underwent endometrial ablation from 2012 to 2014. They were randomly divided in two groups: 50 patients treated with monopolar electrode resection loop (group A) and 50 patients treated with bipolar electrode resection loop (group B)...
November 15, 2016: Minerva Ginecologica
https://www.readbyqxmd.com/read/27821168/associations-of-proteins-relevant-to-mapk-signaling-pathway-p38mapk-1-hif-1-and-ho-1-with-coronary-lesion-characteristics-and-prognosis-of-peri-menopausal-women
#10
Liqiu Yan, Xufen Cao, Saitian Zeng, Zhe Li, Zheng Lian, Jiawang Wang, Fengfeng Lv, Yunfei Wang, Yanshen Li
BACKGROUND: The present study was intended to explore whether three proteins within MAPK signaling pathway (i.e. p38MAPK-1, HIF-1 and HO-1) were correlated with peri-menopausal women's coronary lesion features and prognosis. METHODS: Altogether 1449 peri-menopausal women were divided into non-coronary artery disease (CAD) group (n = 860) and CAD group (n = 589), including 167 pre-menopausal CAD populations and 422 post-menopausal CAD populations. General information about CAD risk parameters were gathered, including age, family history of CAD or hypertension or diabetes mellitus, bilirubin, cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) and so on...
November 8, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27621257/the-interlace-study-design-data-harmonization-and-characteristics-across-20-studies-on-women-s-health
#11
Gita D Mishra, Hsin-Fang Chung, Nirmala Pandeya, Annette J Dobson, Lee Jones, Nancy E Avis, Sybil L Crawford, Ellen B Gold, Daniel Brown, Lynette L Sievert, Eric Brunner, Janet E Cade, Victoria J Burley, Darren C Greenwood, Graham G Giles, Fiona Bruinsma, Alissa Goodman, Kunihiko Hayashi, Jung Su Lee, Hideki Mizunuma, Diana Kuh, Rachel Cooper, Rebecca Hardy, Carla Makhlouf Obermeyer, Kathryn A Lee, Mette Kildevæld Simonsen, Toyoko Yoshizawa, Nancy F Woods, Ellen S Mitchell, Mark Hamer, Panayotes Demakakos, Sven Sandin, Hans-Olov Adami, Elisabete Weiderpass, Debra Anderson
OBJECTIVES: The International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease Events (InterLACE) project is a global research collaboration that aims to advance understanding of women's reproductive health in relation to chronic disease risk by pooling individual participant data from several cohort and cross-sectional studies. The aim of this paper is to describe the characteristics of contributing studies and to present the distribution of demographic and reproductive factors and chronic disease outcomes in InterLACE...
October 2016: Maturitas
https://www.readbyqxmd.com/read/27506466/menopause-induced-uterine-epithelium-atrophy-results-from-arachidonic-acid-prostaglandin-e2-axis-inhibition-mediated-autophagic-cell-death
#12
Shengtao Zhou, Linjie Zhao, Tao Yi, Yuquan Wei, Xia Zhao
Women experience menopause later in life. Menopause is characterized by dramatically decreased circulating estrogen level secondary to loss of ovarian function and atrophic state of genital organs. However, the molecular mechanisms for this process are not fully understood. In this study, we aimed to investigate the potential molecular mechanisms that underlie menopause-induced uterine endometrial atrophy. Our data showed that autophagy was activated in the uterine epithelial cells of both ovariectomized rats and peri-menopausal females...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27294327/triglyceride-levels-and-fracture-risk-in-midlife-women-study-of-women-s-health-across-the-nation-swan
#13
Po-Yin Chang, Ellen B Gold, Jane A Cauley, Wesley O Johnson, Carrie Karvonen-Gutierrez, Elizabeth A Jackson, Kristine M Ruppert, Jennifer S Lee
CONTEXT: Unfavorable lipid levels contribute to cardiovascular disease and may also harm bone health. OBJECTIVE: Our objective was to investigate relationships between fasting plasma lipid levels and incident fracture in midlife women undergoing the menopausal transition. DESIGN AND SETTING: This was a 13-year prospective, longitudinal study of multiethnic women in five US communities, with near-annual assessments. PARTICIPANTS: At baseline, 2062 premenopausal or early perimenopausal women who had no history of fracture were included...
September 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27265705/does-menopausal-transition-really-influence-mental-health-findings-from-the-prospective-long-term-zurich-study
#14
Wulf Rössler, Vladeta Ajdacic-Gross, Anita Riecher-Rössler, Jules Angst, Michael P Hengartner
In the prospective long-term Zurich study, we re-examined the hypothesized association between mental health problems in women and the transition through menopausal stages. One hundred sixty-eight women from a population-based Swiss community cohort were prospectively followed up from age 21 to 50. At age 50, the occurrence of hot flushes/night sweats and sleep disturbances was significantly more frequent in peri- and post-menopausal women. Irritability/nervousness was increased only in peri-menopausal women, but that association was accounted for by neuroticism trait scores at age 30...
June 2016: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/27261985/osteopathic-manipulative-treatment-in-gynecology-and-obstetrics-a-systematic-review
#15
REVIEW
Nuria Ruffini, Giandomenico D'Alessandro, Lucia Cardinali, Franco Frondaroli, Francesco Cerritelli
OBJECTIVE: The aim of the review was to evaluate the effects of the osteopathic manipulative treatment (OMT) on women with gynaecological and obstetric disorders. MATERIALS AND METHODS: An extensive search from inception to April 2014 was conducted on MEDLINE, Embase, the Cochrane library using MeSH and free terms. Clinical studies investigating the effect of OMT in gynaecologic and obstetric conditions were included as well as unpublished works. Reviews and personal contributions were excluded...
June 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27139906/vitamin-e-homologues-%C3%AE-and-%C3%AE-tocopherol-are-not-associated-with-bone-turnover-markers-or-bone-mineral-density-in-peri-menopausal-and-post-menopausal-women
#16
T C Yang, G G Duthie, L S Aucott, H M Macdonald
UNLABELLED: In a large cohort of older women, we investigated the relationships that different forms of vitamin E may have with bone turnover markers and bone mineral density (BMD). We found a suggestive positive association between serum alpha-tocopherol and BMD at the femoral neck, but no other clinically relevant observations. INTRODUCTION: Vitamin E has anti-oxidant and anti-inflammatory properties hypothesized to benefit bone, but limited studies exist regarding its homologues...
July 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27042516/profile-of-breast-diseases-in-post-pubertal-women-assessed-by-clinical-breast-examination-a-community-based-study-in-rural-pondicherry
#17
Kavasseri L Janaki, Narayanasamy Subbaraju Kannan, M Palaniappan, Partha Nandi
INTRODUCTION: Breast diseases in women, whether benign or malignant, are very commonly encountered. Benign diseases are under reported and cancer is one of the leading causes of mortality in women. This study was undertaken with an aim to study the profile of various breast disease in the community. MATERIALS AND METHODS: In this observational study all the post pubertal women residing in the selected village (n=1000) were included. The study was done from September 2013 to August 2015...
February 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26993224/effects-of-estrogen-on-cerebrovascular-function-age-dependent-shifts-from-beneficial-to-detrimental-in-small-cerebral-arteries-of-the-rat
#18
Rachel R Deer, John N Stallone
In the present study, interactions of age and estrogen in the modulation of cerebrovascular function were examined in small arteries <150 μM. The hypothesis tested was that age enhances deleterious effects of exogenous estrogen by augmenting constrictor prostanoid (CP)-potentiated reactivity of the female (F) cerebrovasculature. F Sprague-Dawley rats approximating key stages of "hormonal aging" in humans were studied: perimenopausal (mature multi-gravid, MA, cyclic, 5-6 mo of age) and postmenopausal (reproductively senescent, RS, acyclic 10-12 mo of age)...
May 15, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/26951639/reducing-inappropriate-testing-in-the-diagnosis-of-the-menopause-and-peri-menopause
#19
Jac Williams, Heather Currie, Adele Foster, Julia Anderson
The menopause should be diagnosed based on age, menstrual history and clinical symptoms, and as such, follicle stimulating hormone testing may be considered inappropriate when diagnosing the menopause or peri-menopause in women aged 45 and over. As part of a demand optimisation programme, the number of follicle stimulating hormone tests requested to diagnose the menopause in this age group was quantified and educational interventions were implemented to reduce inappropriate testing. The number of follicle stimulating hormone tests requested to diagnose the menopause in women aged 45 and over was successfully and sustainably reduced...
September 2016: Post Reproductive Health
https://www.readbyqxmd.com/read/26940232/is-menopausal-status-related-to-women-s-attitudes-toward-menopause-and-aging
#20
Doyel Dasgupta, Subha Ray
The objective of this study was to explore the relationship between menopausal status and attitudes toward menopause and aging. We identified 1,400 Bengali Hindu women aged 40-55 years (early perimenopausal n = 445; late perimenopausal n = 240; early postmenopausal n = 285; late postmenopausal n = 430) from West Bengal, India. Information on attitudes toward menopause and aging was collected from March 2009 to July 2012 using ten agree/disagree statements, of which three were positive, four were negative, and the rest were neutral...
March 2017: Women & Health
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