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REVIEW
Seda Grigoryan, Gregory A Clines
Skeletal modeling in childhood and adolescence and continuous remodeling throughout the lifespan are designed to adapt to a changing environment and resist external forces and fractures. The flux of sex steroids in men and women, beginning from fetal development and evolving through infancy, childhood, puberty, young adulthood, peri/menopause transition, and post-menopause, is critical for bone size, peak bone mass, and the risk for fractures. The contributions of estrogen and testosterone on skeletal development have been difficult to study due to the reciprocal and intertwining contributions of one on the other...
April 15, 2024: Endocrine Practice
#2
REVIEW
Michal Olejarz, Ewelina Szczepanek-Parulska, Marek Ruchala
Dyslipidemia is one of the most common disorders worldwide, which, if left untreated, results in a multitude of complications. Thus proper diagnostics, which includes identifying of secondary causes of dyslipidemia is crucial. Endocrine disorders are an important cause of secondary dyslipidemia. This paper aims to review the publications on lipoprotein alterations in endocrine disorders from the past two years and provide an overview of the recent discoveries in this dynamically developing and large field. Significant changes in lipoprotein serum concentrations are present in most endocrinological diseases and can be modified with proper treatment...
2024: Frontiers in Endocrinology
#3
JOURNAL ARTICLE
Dana R Riedy, Sarah M Ghose, Sahar M Sabet, Morgan P Reid, Claire M Williams, Ashley MacPherson, Natalie D Dautovich
Midlife individuals assigned female at birth are at risk for problematic eating behavior, associated with negative health outcomes. Little is known about how menopausal symptoms may increase risk in this population. The current study aimed to understand how a comprehensive range of menopause symptoms were globally associated with problematic eating behaviors. A total of 281 cisgender women (176 post-menopause, 105 peri-menopause) from the United States aged 40 to 64 were recruited utilizing Prolific, an online survey platform...
April 14, 2024: Women & Health
#4
JOURNAL ARTICLE
M de Jong, D S M R Wynchank, M Michielsen, A T F Beekman, J J S Kooij
Background : The diagnostics and treatment of attention-deficit/hyperactivity disorder (ADHD) in women remain insufficient. Fluctuations of reproductive hormones during the premenstrual period, postpartum period, and (peri)menopause are neglected, even though they impact ADHD symptoms and associated mood disorders. Therefore, we created a female-specific treatment group for women with ADHD and premenstrual worsening of ADHD and/or mood symptoms. Methods : We describe the group programme and underlying rationale, offering a qualitative analysis of the participants' evaluation...
April 4, 2024: Journal of Clinical Medicine
#5
JOURNAL ARTICLE
Talar S Habeshian, Noah C Peeri, Immaculata De Vivo, Leo J Schouten, Xiao-Ou Shu, Michele L Cote, Kimberly A Bertrand, Yu Chen, Megan A Clarke, Tess V Clendenen, Linda S Cook, Laura Costas, Luigino Dal Maso, Jo L Freudenheim, Christine M Friedenreich, Grace Gallagher, Gretchen L Gierach, Marc T Goodman, Susan J Jordan, Carlo La Vecchia, James V Lacey, Fabio Levi, Linda M Liao, Loren Lipworth, Lingeng Lu, Xavier Matías-Guiu, Kirsten B Moysich, George L Mutter, Renhua Na, Jeffin Naduparambil, Eva Negri, Kelli O'Connell, Tracy A O'Mara, Irene Onieva Hernández, Julie R Palmer, Fabio Parazzini, Alpa V Patel, Kathryn L Penney, Anna E Prizment, Fulvio Ricceri, Harvey A Risch, Carlotta Sacerdote, Sven Sandin, Rachael Z Stolzenberg-Solomon, Piet A van den Brandt, Penelope M Webb, Nicolas Wentzensen, Akemi T Wijayabahu, Lynne R Wilkens, Wanghong Xu, Herbert Yu, Anne Zeleniuch-Jacquotte, Wei Zheng, Mengmeng Du, Veronica Wendy Setiawan
BACKGROUND: The incidence rates of endometrial cancer (EC) are increasing, which may partly be explained by the rising prevalence of obesity, an established risk factor for EC. Hypertension, another component of metabolic syndrome, is also increasing in prevalence, and emerging evidence suggests that it may be associated with the development of certain cancers. The role of hypertension independent of other components of metabolic syndrome in the etiology of EC remains unclear. In this study we evaluated hypertension as an independent risk factor for EC and whether this association is modified by other established risk factors...
March 26, 2024: Cancer Epidemiology, Biomarkers & Prevention
#6
JOURNAL ARTICLE
Rebecca A Hubbard, Yu-Ru Su, Erin Ja Bowles, Laura Ichikawa, Karla Kerlikowske, Kathryn P Lowry, Diana L Miglioretti, Anna N A Tosteson, Karen J Wernli, Janie M Lee
BACKGROUND: Annual surveillance mammography is recommended for women with a personal history of breast cancer. Risk prediction models that estimate mammography failures such as interval second breast cancers could help to tailor surveillance imaging regimens to women's individual risk profiles. METHODS: In a cohort of women with a history of breast cancer receiving surveillance mammography in the Breast Cancer Surveillance Consortium in 1996-2019, we used LASSO-penalized regression to estimate the probability of an interval second cancer (invasive cancer or ductal carcinoma in situ) in the one-year following a negative surveillance mammogram...
March 11, 2024: Journal of the National Cancer Institute
#7
JOURNAL ARTICLE
Elisabet Alzueta, Luca Menghini, Laila Volpe, Fiona C Baker, Ann Garnier, Philip M Sarrel, Massimiliano de Zambotti
OBJECTIVE: Women's increasing workforce participation necessitates understanding unique life phases like menopause for enhanced workplace inclusivity. This research investigates the challenges and needs of peri-menopausal women in work settings, using the Job Demands-Resources model as a foundation. METHODS: A cross-sectional survey was administered to 351 working women aged 40 to 65 years in the United States. Hierarchical multiple regression models were employed to assess the relationship between the severity of menopausal symptoms, emotional exhaustion, work engagement, and turnover intentions...
March 5, 2024: Menopause: the Journal of the North American Menopause Society
#8
REVIEW
Kim Pauwaert, An-Sofie Goessaert, Dudley Robinson, Linda Cardozo, Wendy Bower, Patrick Calders, An Mariman, Paul Abrams, Andrea Tubaro, Roger Dmochowski, Jeffrey P Weiss, Francois Hervé, Herman Depypere, Karel Everaert
INTRODUCTION AND HYPOTHESIS: The aim of this review is to discuss the link between menopause and nocturia and to give an overview of the increasing prevalence, risk factors, causative factors, treatment needs and options for nocturia in peri-menopausal women. METHODS: This opinion article is a narrative review based on the expertise and consensus of a variety of key opinion leaders, in combination with an extensive literature review. This literature search included a thorough analysis of potential publications on both the PubMed Database and the Web of Science and was conducted between November 2022 and December 2022...
March 4, 2024: International Urogynecology Journal
#9
JOURNAL ARTICLE
Malvika Gulati, Gretchen Brewer, Andrew Judge, Donna Kennedy, Tonia L Vincent, Fiona E Watt
INTRODUCTION: Hand osteoarthritis is more common in women, and its risk increases around the time of the menopause. We set out to describe the timing between menopause and the onset of symptomatic hand osteoarthritis (OA), and associations with the use of hormone replacement therapy (HRT) or its discontinuation, describing any identifiable subgroups of women. METHODS: Retrospective healthcare-records study of sequential women referred to a specialist hand OA clinic, 2007-2015...
2024: Front Pain Res (Lausanne)
#10
JOURNAL ARTICLE
Sabina Rinaldi, Laure Dossus, Pekka Keski-Rahkonen, Agneta Kiss, Anne-Sophie Navionis, Carine Biessy, Ruth Travis, Elisabete Weiderpass, Isabelle Romieu, Anne Kirstine Eriksen, Anne Tjonneland, Marina Kvaskoff, Marianne Canonico, Thérèse Truong, Verena Katzke, Rudolf Kaaks, Alberto Catalano, Salvatore Panico, Giovanna Masala, Rosario Tumino, Marko Lukic, Karina Standahl Olsen, Raul Zamora-Ros, Carmen Santiuste, Amaia Aizpurua Atxega, Marcela Guevara, Miguel Rodriguez-Barranco, Maria Sandstrom, Joakim Hennings, Martin Almquist, Elom Aglago Kouassivi, Sofia Christakoudi, Marc Gunter, Silvia Franceschi
Thyroid cancer (TC) is substantially more common in women than in men, pointing to a possible role of sex steroid hormones. We investigated the association between circulating sex steroid hormones, sex hormone binding globulin (SHBG) and the risk of differentiated TC in men and women within the European Prospective Investigation into Cancer and nutrition (EPIC) cohort. During follow-up, we identified 333 first primary incident cases of differentiated TC (152 in pre/peri-menopausal women, 111 in post-menopausal women, and 70 in men) and 706 cancer-free controls...
February 15, 2024: International Journal of Cancer. Journal International du Cancer
#11
Abigail E Salinero, Harini Venkataganesh, Charly Abi-Ghanem, David Riccio, Richard D Kelly, Olivia J Gannon, Avi Sura, Heddwen L Brooks, Kristen L Zuloaga
Menopause accelerates metabolic dysfunction, including (pre-)diabetes, obesity and visceral adiposity. However, the effects of endocrine vs. chronological aging in this progression are poorly understood. We hypothesize that menopause, especially in the context of middle-age, will exacerbate the metabolic effects of a high fat diet. Using young-adult and middle-aged C57BL/6J female mice, we modeled diet-induce obesity via chronic administration of high fat (HF) diet vs. control diet. We modeled peri-menopause/menopause via injections of 4-vinylcyclohexene diepoxide, which accelerates ovarian failure vs...
January 19, 2024: bioRxiv
#12
REVIEW
Charlotte Gatenby, Paul Simpson
The menopause transition is usually a gradual process occurring over many years, caused by the cessation of ovarian reproductive function, resulting in the end of menstrual bleeding. In the peri-menopause, ovarian function and therefore the production of the hormones oestrogen, progesterone and testosterone can fluctuate greatly, leading to a wide variety of symptoms, affecting multiple organ systems. Menopause and the management of its associated symptoms can be very challenging for patients and clinicians alike and can negatively impact quality of life...
January 2024: Best Practice & Research. Clinical Endocrinology & Metabolism
#13
JOURNAL ARTICLE
Shona Brown, Tessa Noakes, Theresa Foster, Larissa Prothero
INTRODUCTION: Menopause is a key workplace issue. Many women will experience symptoms through their later working life. The ambulance service constitutes an employment setting that, dependent on the roles of female staff, can impact on the severity of menopause symptoms and experiences (Prothero et al., 2021). This study aimed to explore female ambulance staff experiences of the menopause transition and suggest ways to improve support offerings. METHODS: A qualitative interpretive approach was adopted, involving 12 UK ambulance services...
December 1, 2023: British paramedic journal
#14
REVIEW
Lucy C Barker, Simone N Vigod
PURPOSE OF REVIEW: Schizophrenia spectrum disorders (SSD) impact many aspects of reproductive health for women and non-binary and transgender individuals assigned female at birth. In this narrative review, we highlight considerations and recent research related to (1) the premenopausal period, (2) pregnancy and postpartum, and (3) the menopausal transition. RECENT FINDINGS: Most recent research has focused on pregnancy and the postpartum period, and specifically on elucidating perinatal risk factors, adverse obstetrical and neonatal outcomes (and modifiable contributors such as smoking), long-term child health, and psychotropic medications (with reassuring results related antipsychotic-associated gestational diabetes mellitus and neurodevelopmental outcomes)...
October 31, 2023: Current Psychiatry Reports
#15
JOURNAL ARTICLE
Alexandra M Bodnaruc, Miryam Duquet, Denis Prud'homme, Isabelle Giroux
The aim of the proposed scoping review is to describe and summarize studies assessing the associations between diet-related variables and depression in peri- and post-menopausal women. Studies examining the associations between diet-related variables and mental health indicators in women undergoing menopausal transition or in the post-menopausal period will be systematically retrieved via Medline, EMBASE, PsycINFO, Web of Science, and Scopus databases. All articles identified through the database searches will be imported into Covidence...
October 2, 2023: Methods and Protocols
#16
JOURNAL ARTICLE
Abhishek Jana, Jincy Thomas, Pratiti Ghosh
BACKGROUND: Oral lichen planus (OLP) is an autoimmune disease primarily affecting the middle-aged females. The present study aims to determine the relation of the oestrogen receptor alpha (ERα) with OLP pathogenesis, correlating it with the possible cause of its higher prevalence among females. MATERIALS AND METHODS: Clinically and histologically identified fifteen of each pre-menopausal and peri-menopausal OLP female patients were chosen for this study. The expression of ERα was analysed from the collected lesion tissue samples by using two-step semi-quantitative reverse transcriptase polymerase chain reaction (SqRT-PCR) and enzyme-linked immunosorbent assay (ELISA)...
2023: Indian Journal of Dermatology
#17
JOURNAL ARTICLE
Daniel H Solomon, Kristine Ruppert, Jane A Cauley, Yinjuan Lian, Hallie Altwies, Albert Shieh, Sherri-Ann M Burnett-Bowie
UNLABELLED: We examined longitudinal changes in BMD among women in the mid-life starting metformin. Study subjects were 57 years old (mean), and 36% were White. Women initiating metformin were similar to noninitiators. During the 3-year follow-up, BMD loss at all anatomic areas was similar between groups and in subgroups including baseline fasting blood glucose. PURPOSE/INTRODUCTION: Women with type 2 diabetes have higher bone mineral density (BMD), experience slower BMD loss, but have increased fracture risk...
September 21, 2023: Osteoporosis International
#18
REVIEW
Scotti McLaren, Karin Seidler, James Neil
Low serotonin is one factor implicated in the development of depression. 17β-estradiol (E2) has been shown to modulate gene expression regulating the neurotransmission of serotonin. Sex hormone levels fluctuate dramatically during the menopausal transition, coinciding with a 14-fold increased risk of depression. This review aimed to examine the effect of soy isoflavones to support decreased and variable E2 levels before and after menopause, linked to an investigation of the pathophysiological mechanisms underlying the protective influence of E2 on the serotonin pathway...
September 11, 2023: J Am Nutr Assoc
#19
JOURNAL ARTICLE
Hee Jung Cho, Sukhee Ahn
PURPOSE: The purpose of this study was to comprehensively understand and describe the meaning of physical activity for managing menopausal symptoms in middle-aged women. METHODS: This study targeted middle-aged women with menopausal symptoms who participated in regular exercise at least three times a week for more than 12 weeks. Nine participants were individually interviewed via in-depth face-to-face interviews, and participatory observation was also employed. Colaizzi's phenomenological qualitative research method was applied for analysis...
June 2023: Korean journal of women health nursing
#20
JOURNAL ARTICLE
Tafadzwa Madanhire, Samuel Hawley, Ethel Dauya, Tsitsi Bandason, Ruramayi Rukuni, Rashida A Ferrand, Celia L Gregson
BACKGROUND: The scale-up of antiretroviral therapy programmes has resulted in increased life expectancy of people with HIV in Africa. Little is known of the menopausal experiences of African women, including those living with HIV. We aimed to determine the prevalence and severity of self-reported menopause symptoms in women at different stages of menopause transition, by HIV status, and evaluate how symptoms are related to health-related quality of life (HRQoL). We further sought to understand factors associated with menopause symptoms...
June 29, 2023: BMC Women's Health
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