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Synuclein tomm40

William K Gottschalk, Michael W Lutz, Yu Ting He, Ann M Saunders, Daniel K Burns, Allen D Roses, Ornit Chiba-Falek
Mitochondrial dysfunction is an important factor in the pathogenesis of age-related diseases, including neurodegenerative diseases like Alzheimer's and Parkinson's spectrum disorders. A polymorphism in Translocase of the Outer Mitochondrial Membrane - 40 kD (TOMM40) is associated with risk and age-of onset of late-onset AD, and is the only nuclear- encoded gene identified in genetic studies to date that presumably contributes to LOAD-related mitochondria dysfunction. In this review, we describe the TOM40-mediated mitochondrial protein import mechanism, and discuss the evidence linking TOM40 with Alzheimer's (AD) and Parkinson's (PD) diseases...
November 2014: Journal of Parkinson's Disease and Alzheimer's Disease
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