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https://www.readbyqxmd.com/read/28871888/subproteomic-signature-comparison-of-in-vitro-selected-fluoroquinolone-resistance-and-ciprofloxacin-stress-in-salmonella-typhimurium-dt104b
#1
Susana Correia, Michel Hébraud, Ingrid Chafsey, Christophe Chambon, Didier Viala, Carmen Torres, Manuela Caniça, José Luis Capelo, Patrícia Poeta, Gilberto Igrejas
BACKGROUND: Fluoroquinolone resistance in nontyphoidal Salmonella is a situation of serious and international concern, particularly in S. Typhimurium DT104B multiresistant strains. Although known to be multifactorial, fluoroquinolone resistance is still far from a complete understanding. AIM AND METHODS: To evaluate subproteome changes between an experimentally selected fluoroquinolone-resistant strain (Se6-M) and its parent strain (Se6), and also in Se6-M under ciprofloxacin (CIP) stress, in order to give new insights into the mechanisms involved...
September 5, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28871377/the-maize-cora-mrs2-mgt-type-mg-transporter-zmmgt10-responses-to-magnesium-deficiency-and-confers-low-magnesium-tolerance-in-transgenic-arabidopsis
#2
Hongyou Li, Ning Wang, Jianzhou Ding, Chan Liu, Hanmei Du, Kaifeng Huang, Moju Cao, Yanli Lu, Shibin Gao, Suzhi Zhang
ZmMGT10 was specifically expressed in maize roots and induced by a deficiency of magnesium. Overexpression of ZmMGT10 restored growth deficiency of the Salmonella typhimurium MM281 strain and enhanced the tolerance in Arabidopsis to stress induced by low magnesium levels by increasing uptake of Mg(2+) via roots. CorA/MRS2/MGT-type Mg(2+) transporters play a significant role in maintaining magnesium (Mg) homeostasis in plants. Although the maize CorA/MRS2/MGT family comprises of 12 members, currently no member has been functionally characterized...
September 4, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/28868219/appraisal-of-biochemical-classes-of-radioprotectors-evidence-current-status-and-guidelines-for-future-development
#3
REVIEW
Krishnanand Mishra, Ghazi Alsbeih
The search for efficient radioprotective agents to protect from radiation-induced toxicity, due to planned or accidental radiation exposure, is still ongoing worldwide. Despite decades of research and development of widely different biochemical classes of natural and derivative compounds, a safe and effective radioprotector is largely unmet. In this comprehensive review, we evaluated the evidence for the radioprotective performance of classical thiols, vitamins, minerals, dietary antioxidants, phytochemicals, botanical and bacterial preparations, DNA-binding agents, cytokines, and chelators including adaptogens...
October 2017: 3 Biotech
https://www.readbyqxmd.com/read/28827093/in-silico-identification-and-characterization-of-stress-and-virulence-associated-repeats-in-salmonella
#4
Gourab Das, Surojit Das, Shanta Dutta, Indira Ghosh
So much genomic similarities yet causing different diseases, is like a paradox in Salmonella biology. Repeat is one of the probes that can explain such differences. Here, a comparative genomics approach is followed to identify and characterize repeats that might play role in adaptation and pathogenesis. Repeats are non-randomly distributed in the genomes except few typhoid causing strains. Perfect long repeats are rare compare to polymorphic ones and both are statistically consistent. Significant differences in repeat densities in stress related genes manifest its probable participation in survival and virulence...
August 4, 2017: Genomics
https://www.readbyqxmd.com/read/28802266/functional-analysis-of-genes-encoded-by-the-locus-of-heat-resistance-lhr-in-escherichia-coli
#5
Ryan Mercer, Oanh Nguyen, Qixing Ou, Lynn McMullen, Michael G Gänzle
The locus of heat resistance (LHR) is a 15 - 19 kb genomic island conferring exceptional heat resistance to organisms in the family Enterobacteriaceae including pathogenic strains of Salmonella enterica and Escherichia coli The complement of LHR-encoded genes that is necessary for heat resistance and the stress- or growth-phase induced expression of LHR-encoded genes are unknown. This study determined the contribution of the 7 LHR-encoded genes yfdX1GI, yfdX2, hdeDGI, orf11, trxGI, kefB, and psiEGI by comparison of the heat resistance of E...
August 11, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28802055/effect-of-storage-temperatures-and-stresses-on-the-survival-of-salmonella-spp-in-halva
#6
Tareq M Osaili, Anas A Al-Nabulsi, Dima S Nazzal, Reyad R Shaker
The presence of Salmonella spp. in halva has been associated with foodborne illnesses and product recalls from the markets. This study investigated the effect of environmental stresses on the survival of Salmonella spp. in halva during storage for 12 months at 10 and 25°C. Halva samples were inoculated with a cocktail of four strains of unstressed, desiccation stressed or heat stressed Salmonella (10(6) -10(7) CFU g(-1) ). In general, survival of Salmonella spp. in halva decreased significantly (P ˂ 0.05) as storage time and temperature increased...
August 12, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28796533/6s-rna-is-involved-in-acid-resistance-and-invasion-of-epithelial-cells-in-salmonella-enterica-serovar-typhimurium
#7
Jie Ren, Yu Sang, Ran Qin, Zhongli Cui, Yu-Feng Yao
AIM: Acid is an important environmental condition encountered frequently by Salmonella enterica serovar Typhimurium during its pathogenesis, but the role of small-noncoding RNAs (sRNAs) in response to acid stress is poorly understood. METHODS: We used RNA sequencing to explore acid-responsive sRNAs in S. Typhimurium. RESULTS: It identified that 6S RNA encoded by the ssrS was significantly upregulated at pH 3.0. The 6S RNA knockout strain showed a reduced ability to survive at pH 3...
August 10, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28741960/retention-of-viability-of-salmonella-in-sucrose-as-affected-by-type-of-inoculum-water-activity-and-storage-temperature
#8
Larry R Beuchat, David A Mann, Christine A Kelly, Ynes R Ortega
Outbreaks of salmonellosis have been associated with consumption of high-sugar, low-water activity (aw) foods. The study reported here was focused on determining the effect of storage temperature (5 and 25°C) on survival of initially high and low levels of Salmonella in dry-inoculated sucrose (aw 0.26 ± 0.01 to 0.54 ± 0.01) and wet-inoculated sucrose (aw 0.24 ± 0.01 to 0.44 ± 0.04) over a 52-week period. With the exception of dry-inoculated sucrose at aw 0.26, Salmonella survived for 52 weeks in dry- and wet-inoculated sucrose stored at 5 and 25°C...
September 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28736216/pathogen-induced-tlr4-trif-innate-immune-signaling-in-hematopoietic-stem-cells-promotes-proliferation-but-reduces-competitive-fitness
#9
Hitoshi Takizawa, Kristin Fritsch, Larisa V Kovtonyuk, Yasuyuki Saito, Chakradhar Yakkala, Kurt Jacobs, Akshay K Ahuja, Massimo Lopes, Annika Hausmann, Wolf-Dietrich Hardt, Álvaro Gomariz, César Nombela-Arrieta, Markus G Manz
Bacterial infection leads to consumption of short-lived innate immune effector cells, which then need to be replenished from hematopoietic stem and progenitor cells (HSPCs). HSPCs express pattern recognition receptors, such as Toll-like receptors (TLRs), and ligation of these receptors induces HSPC mobilization, cytokine production, and myeloid differentiation. The underlying mechanisms involved in pathogen signal transduction in HSCs and the resulting biological consequences remain poorly defined. Here, we show that in vivo lipopolysaccharide (LPS) application induces proliferation of dormant HSCs directly via TLR4 and that sustained LPS exposure impairs HSC self-renewal and competitive repopulation activity...
August 3, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28727116/technical-note-development-of-a-feed-matrix-as-inoculum-in-salmonella-infection-studies-in-piglets
#10
R Litjens, A-K Oudshoorn, P J Roubos-van den Hil
Current methods used for oral administration of pathogens to piglets are stressful for the animals because of fixation and use of inoculation methods such as oral gavage. In the present study an alternative way to challenge piglets with Typhimurium (ST) is investigated. The strategy was to incorporate the in a feed matrix, which is fed to the piglets and eaten voluntary. Different types of feed matrices were tested for their absorption capacity, handling properties, and palatability to piglets. Furthermore, the viability of ST in feed matrices was studied...
July 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28727113/feed-withdrawal-and-transportation-effects-on-salmonella-enterica-levels-in-market-weight-pigs
#11
S D Eicher, M H Rostagno, D C Lay
Feed withdrawal and transport commonly occur together in pigs. Objectives of this study were to determine if these preslaughter stressors, feed withdrawal and transportation, affect the levels of , stress hormone concentrations, and immune functions in infected market pigs. A 2 × 2 factorial analysis of a randomized complete block design with feed withdrawal and transport as fixed effects was used. Sixty market-weight pigs were individually inoculated with serovar Typhimurium. The experiment was replicated 3 times (blocking factor) with 20 pigs per replicate...
July 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28720734/lack-of-acrb-efflux-function-confers-loss-of-virulence-on-salmonella-enterica-serovar-typhimurium
#12
Xuan Wang-Kan, Jessica M A Blair, Barbara Chirullo, Jonathan Betts, Roberto M La Ragione, Alasdair Ivens, Vito Ricci, Timothy J Opperman, Laura J V Piddock
AcrAB-TolC is the paradigm resistance-nodulation-division (RND) multidrug resistance efflux system in Gram-negative bacteria, with AcrB being the pump protein in this complex. We constructed a nonfunctional AcrB mutant by replacing D408, a highly conserved residue essential for proton translocation. Western blotting confirmed that the AcrB D408A mutant had the same native level of expression of AcrB as the parental strain. The mutant had no growth deficiencies in rich or minimal medium. However, compared with wild-type SL1344, the mutant had increased accumulation of Hoechst 33342 dye and decreased efflux of ethidium bromide and was multidrug hypersusceptible...
July 18, 2017: MBio
https://www.readbyqxmd.com/read/28677399/super-cationic-carbon-quantum-dots-synthesized-from-spermidine-as-an-eye-drop-formulation-for-topical-treatment-of-bacterial-keratitis
#13
Hong-Jyuan Jian, Ren-Siang Wu, Tzu-Yu Lin, Yu-Jia Li, Han-Jia Lin, Scott G Harroun, Jui-Yang Lai, Chih-Ching Huang
We have developed a one-step method to synthesize carbon quantum dots (CQDPAs) from biogenic polyamines (PAs) as an antibacterial agent for topical treatment of bacterial keratitis (BK). CQDs synthesized by direct pyrolysis of spermidine (Spd) powder through a simple dry heating treatment exhibit a solubility and yield much higher than those from putrescine and spermine. We demonstrate that CQDs obtained from Spds (CQDSpds) possess effective antibacterial activities against non-multidrug-resistant Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Salmonella enterica serovar Enteritidis bacteria and also against the multidrug-resistant bacteria, methicillin-resistant S...
July 25, 2017: ACS Nano
https://www.readbyqxmd.com/read/28674031/role-of-sapa-and-yfga-in-susceptibility-to-antibody-mediated-complement-dependent-killing-and-virulence-of-salmonella-enterica-serovar-typhimurium
#14
Edna M Ondari, Jennifer N Heath, Elizabeth J Klemm, Gemma Langridge, Lars Barquist, David A Goulding, Simon Clare, Gordon Dougan, Robert A Kingsley, Calman A MacLennan
The ST313 pathovar of Salmonella enterica serovar Typhimurium contributes to a high burden of invasive disease among African infants and HIV-infected adults. It is characterized by genome degradation (loss of coding capacity) and has increased resistance to antibody-dependent complement-mediated killing compared with enterocolitis-causing strains of S Typhimurium. Vaccination is an attractive disease-prevention strategy, and leading candidates focus on the induction of bactericidal antibodies. Antibody-resistant strains arising through further gene deletion could compromise such a strategy...
September 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28666873/overexpression-of-mica-induces-production-of-ompc-enriched-outer-membrane-vesicles-that-protect-against-salmonella-challenge
#15
Hyun-Il Choi, Moonjeong Kim, Jinseong Jeon, Jin Kwan Han, Kwang-Sun Kim
Outer membrane vesicles (OMVs) derived from bacteria are promising candidates for subunit vaccines. Stresses that modulate the composition of outer membrane proteins (OMPs) are important for OMV synthesis. Small RNAs (sRNAs) expressed in response to stress regulate OMPs, although the mechanism underlying sRNA-mediated OMV biogenesis and its utility for developing vaccine platforms remains to be elucidated. Here, we characterized the role of a sRNA, MicA, which regulates OmpA, a major OMP involved in both production of OMVs and reactive immunity against Salmonella challenge...
August 26, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28666217/toxicity-of-coal-fly-ash-cfa-and-toxicological-response-of-switchgrass-in-mycorrhiza-mediated-cfa-soil-admixtures
#16
Olushola M Awoyemi, E Kudjo Dzantor
Increasing support for the use of Coal fly ash (CFA) in agriculture has necessitated a better understanding of the effects of the CFA in various cropping schemes. Experiments were conducted to assess mutagenic response of a mutant strain of Salmonella enterica serovar Typhimurium (TA100) to varying concentrations of CFA-water extracts, determine oxidative stress in switchgrass (Panicum virgatum L.) at varying levels of CFA-soil admixtures, and evaluate mycorrhiza-mediated modulation of oxidative stress responses of CFA-grown switchgrass...
June 27, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28660242/bacterial-autophagy-offense-and-defense-at-the-host-pathogen-interface
#17
REVIEW
James E Casanova
Autophagy is a fundamental cellular process used for the turnover and recycling of cytosolic components and damaged organelles. Originally characterized as a response to cellular stress, it now is well established that autophagy also is used as a defensive mechanism to combat the infection of host cells by intracellular pathogens. However, although this defensive strategy does limit the proliferation of most pathogens within their host cells, successful pathogens have evolved countermeasures that subvert or circumvent the autophagic response...
September 2017: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28660201/the-potential-link-between-thermal-resistance-and-virulence-in-salmonella-a-review
#18
REVIEW
Turki M Dawoud, Morgan L Davis, Si Hong Park, Sun Ae Kim, Young Min Kwon, Nathan Jarvis, Corliss A O'Bryan, Zhaohao Shi, Philip G Crandall, Steven C Ricke
In some animals, the typical body temperature can be higher than humans, for example, 42°C in poultry and 40°C in rabbits which can be a potential thermal stress challenge for pathogens. Even in animals with lower body temperatures, when infection occurs, the immune system may increase body temperature to reduce the chance of survival for pathogens. However, some pathogens can still easily overcome higher body temperatures and/or rise in body temperatures through expression of stress response mechanisms. Salmonella is the causative agent of one of the most prevalent foodborne illnesses, salmonellosis, and can readily survive over a wide range of temperatures due to the efficient expression of the heat (thermal) stress response...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28659929/involvement-of-micrornas-in-probiotics-induced-reduction-of-the-cecal-inflammation-by-salmonella-typhimurium
#19
Qiaoling Chen, Chao Tong, Shaoyang Ma, Luoxiong Zhou, Lili Zhao, Xin Zhao
The microRNAs (miRNAs) have been shown to play important roles in the development of the immune system and in regulation of host inflammation responses. Probiotics can effectively alleviate the inflammation caused by Salmonella in chickens. However, whether and how miRNAs are involved in modulation of the inflammation response in the gut of chickens have not been reported. In this study, the impact of a probiotics, Lactobacillus plantarum Z01 (LPZ01), was investigated on the cecal miRNAs and cytokine secretions in Salmonella Typhimurium (S...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28631419/the-cpxr-cpxa-system-contributes-to-salmonella-gold-resistance-by-controlling-the-gols-dependent-gesabc-transcription
#20
Sebastián Cerminati, Germán F Giri, Julián I Mendoza, Fernando C Soncini, Susana K Checa
Several regulatory systems contribute to bacterial resistance to heavy metals controlling the expression of factors required to eliminate the intoxicant and/or to repair the damage caused by it. In Salmonella, the response to Au ions is mediated by the specific metalloregulator GolS that, among other genes, controls the expression of the RND-efflux pump GesABC. In this work, we demonstrate that CpxR/CpxA, a main cell-envelope stress-responding system, promotes gesABC transcription in the presence of Au ions at neutral pH...
June 19, 2017: Environmental Microbiology
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