keyword
https://read.qxmd.com/read/38534920/sex-based-analysis-of-quality-indicators-of-end-of-life-care-in-gastrointestinal-malignancies
#1
JOURNAL ARTICLE
Caitlin S Lees, Hsien Seow, Kelvin K W Chan, Anastasia Gayowsky, Shaila J Merchant, Aynharan Sinnarajah
Indices of aggressive or supportive end-of-life (EOL) care are used to evaluate health services quality. Disparities according to sex were previously described, with studies showing that male sex is associated with aggressive EOL care. This is a secondary analysis of 69,983 patients who died of a GI malignancy in Ontario between 2006 and 2018. Quality indices from the last 14-30 days of life and aggregate measures for aggressive and supportive EOL care were derived from administrative data. Hospitalizations, emergency department use, intensive care unit admissions, and receipt of chemotherapy were considered indices of aggressive care, while physician house call and palliative home care were considered indices of supportive care...
February 22, 2024: Current Oncology
https://read.qxmd.com/read/38533203/clients-knowledge-and-satisfaction-with-outpatient-pharmacy-services-and-associated-factors-at-felege-hiwot-comprehensive-specialized-hospital-ethiopia-a-cross-sectional-study
#2
JOURNAL ARTICLE
Firdawek Shenkute Ergetie, Abebe Tarekegn Kassaw, Eyayaw Ashete Belachew
OBJECTIVE: This study aimed to assess patient knowledge and satisfaction and associated factors with outpatient pharmacy service at Felege Hiwot comprehensive specialized hospital. DESIGN SETTING AND PARTICIPANTS: An institution-based cross-sectional study was conducted at Felege Hiwot comprehensive specialized hospital on patients getting outpatient Pharmacy service from 01 March 2022 to 30 May 2022. The study participants were selected by simple random sampling method...
2024: SAGE Open Medicine
https://read.qxmd.com/read/38532641/developing-a-process-to-measure-actual-harm-from-medication-errors-in-paediatric-inpatients-from-design-to-implementation
#3
JOURNAL ARTICLE
Virginia Mumford, Magdalena Z Raban, Ling Li, Erin Fitzpatrick, Amanda Woods, Alison Merchant, Tim Badgery-Parker, Peter Gates, Melissa Baysari, Ric O Day, Geoffrey Ambler, Luciano Dalla-Pozza, Madlen Gazarian, Alan Gardo, Peter Barclay, Les White, Johanna I Westbrook
AIMS: The potential harm associated with medication errors is widely reported, but data on actual harm are limited. When actual harm has been measured, assessment processes are often poorly described, limiting their ability to be reproduced by other studies. Our aim was to design and implement a new process to assess actual harm resulting from medication errors in paediatric inpatient care. METHODS: Prescribing errors were identified through retrospective medical record reviews (n = 26 369 orders) and medication administration errors through direct observation (n = 5137 administrations) in a tertiary paediatric hospital...
March 26, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38528799/eligibility-of-emergency-department-patients-for-public-benefit-programs
#4
JOURNAL ARTICLE
Joseph Harrison, Grace McDermott, Erica L Dixon, Michael Mehta, Aliza Haider, Charles Rareshide, Lauren Southwick, Anish K Agarwal, Raina M Merchant, Austin S Kilaru
No abstract text is available yet for this article.
March 25, 2024: Academic Emergency Medicine
https://read.qxmd.com/read/38522964/international-consensus-is-needed-on-a-core-outcome-set-to-advance-the-evidence-of-best-practice-in-cancer-prehabilitation-services-and-research
#5
EDITORIAL
Anna M Myers, Rachael C Barlow, Gabriele Baldini, Anna M Campbell, Franco Carli, Esther J Carr, Tom Collyer, Gerard Danjoux, June F Davis, Linda Denehy, James Durrand, Chelsia Gillis, Diana M Greenfield, Stuart P Griffiths, Mike Grocott, Liam Humphreys, Sandy Jack, Carol Keen, Denny Z H Levett, Zoe Merchant, John Moore, Susan Moug, William Ricketts, Daniel Santa Mina, John M Saxton, Clare E Shaw, Garry A Tew, Michael Thelwell, Malcolm A West, Robert J Copeland
Prehabilitation aims to optimise patients' physical and psychological status before treatment. The types of outcomes measured to assess the impact of prehabilitation interventions vary across clinical research and service evaluation, limiting the ability to compare between studies and services and to pool data. An international workshop involving academic and clinical experts in cancer prehabilitation was convened in May 2022 at Sheffield Hallam University's Advanced Wellbeing Research Centre, England. The workshop substantiated calls for a core outcome set to advance knowledge and understanding of best practice in cancer prehabilitation and to develop national and international databases to assess outcomes at a population level...
March 23, 2024: British Journal of Anaesthesia
https://read.qxmd.com/read/38510450/association-of-intrinsic-capacity-with-functional-ability-sarcopenia-and-systemic-inflammation-in-pre-frail-older-adults
#6
JOURNAL ARTICLE
Reshma Aziz Merchant, Yiong Huak Chan, Denishkrshna Anbarasan, Bruno Vellas
BACKGROUND: Decline in intrinsic capacity (IC) has been shown to accelerate progression to disability. The study aims to explore association of IC composite score with functional ability, sarcopenia and systemic inflammation in pre-frail older adults. METHODS: Cross-sectional study of pre-frail older adults ≥60 years old recruited from the community and primary care centers. Composite scores of four domains of IC were measured: locomotion, vitality, cognition and psychological...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38503461/knowledge-perceptions-attitudes-and-barriers-pertaining-to-genetic-literacy-among-surgeons-a-scoping-review
#7
REVIEW
Zuhaib M Mir, Linda Y N Fei, Sandra McKeown, Rachelle Dinchong, Nicholas Cofie, Nancy Dalgarno, Alison Rusnak, Rona E Cheifetz, Shaila J Merchant
BACKGROUND: The rapid evolution of genetic technologies and utilization of genetic information for clinical decision-making has necessitated increased surgeon participation in genetic counselling, testing, and appropriate referral of patients for genetic services, without formal training in genetics. We performed a scoping review to describe surgeons' knowledge, perceptions, attitudes, and barriers pertaining to genetic literacy in the management of patients who had confirmed cancer or who were potentially genetically at risk...
2024: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://read.qxmd.com/read/38498838/using-computational-phenotyping-to-identify-divergent-strategies-for-effort-allocation-across-the-psychosis-spectrum
#8
JOURNAL ARTICLE
Alexis E Whitton, Jessica A Cooper, Jaisal T Merchant, Michael T Treadway, Kathryn E Lewandowski
BACKGROUND AND HYPOTHESIS: Disturbances in effort-cost decision-making have been highlighted as a potential transdiagnostic process underpinning negative symptoms in individuals with schizophrenia. However, recent studies using computational phenotyping show that individuals employ a range of strategies to allocate effort, and use of different strategies is associated with unique clinical and cognitive characteristics. Building on prior work in schizophrenia, this study evaluated whether effort allocation strategies differed in individuals with distinct psychotic disorders...
March 18, 2024: Schizophrenia Bulletin
https://read.qxmd.com/read/38496567/brain-dynamics-reflecting-an-intra-network-brain-state-is-associated-with-increased-posttraumatic-stress-symptoms-in-the-early-aftermath-of-trauma
#9
Mohammad Sendi, Zening Fu, Nathaniel Harnett, Sanne van Rooij, Victor Vergara, Diego Pizzagalli, Nikolaos Daskalakis, Stacey House, Francesca Beaudoin, Xinming An, Thomas Neylan, Gari Clifford, Tanja Jovanovic, Sarah Linnstaedt, Laura Germine, Kenneth Bollen, Scott Rauch, John Haran, Alan Storrow, Christopher Lewandowski, Paul Musey, Phyllis Hendry, Sophia Sheikh, Christopher Jones, Brittany Punches, Robert Swor, Nina Gentile, Vishnu Murty, Lauren Hudak, Jose Pascual, Mark Seamon, Erica Harris, Anna Chang, Claire Pearson, David Peak, Roland Merchant, Robert Domeier, Niels Rathlev, Brian O'Neil, Paulina Sergot, Leon Sanchez, Steven Bruce, John Sheridan, Steven Harte, Ronald Kessler, Karestan Koenen, Samuel McLean, Jennifer Stevens, Vince Calhoun, Kerry Ressler
This study examines the association between brain dynamic functional network connectivity (dFNC) and current/future posttraumatic stress (PTS) symptom severity, and the impact of sex on this relationship. By analyzing 275 participants' dFNC data obtained ~2 weeks after trauma exposure, we noted that brain dynamics of an inter-network brain state link negatively with current (r=-0.179, p corrected = 0.021) and future (r=-0.166, p corrected = 0.029) PTS symptom severity. Also, dynamics of an intra-network brain state correlated with future symptom intensity (r = 0...
March 8, 2024: Research Square
https://read.qxmd.com/read/38484944/esophageal-enigma-isolated-lower-esophageal-sphincter-amyloidosis
#10
JOURNAL ARTICLE
Alam Merchant, Raul S Gonzalez, Anand Jain
No abstract text is available yet for this article.
March 12, 2024: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/38476589/adherence-to-anti-retroviral-therapy-art-and-its-determinants-among-people-living-with-hiv-aids-at-bonga-kaffa-south-west-ethiopia
#11
JOURNAL ARTICLE
Asrat Tekle, Arega Tsegaye, Tsige Ketema
BACKGROUND: The scaling-up of antiretroviral therapy (ART) is the greatest accomplishment to reduce the burden of acquired immunodeficiency syndromes (AIDS) to date. However, it requires optimal adherence to be effective. Thus, this study was designed to assess the level of adherence of people living with HIV (PLWH) to ART and its determinants in one of the hardest-hit areas with HIV in Ethiopia. METHODS: A health facility-based cross-sectional study design was conducted among adult PLWH, age >18 years, and receiving ART in southwest Ethiopia...
2024: Patient Preference and Adherence
https://read.qxmd.com/read/38474232/myeloid-derived-suppressor-cells-therapeutic-target-for-gastrointestinal-cancers
#12
REVIEW
Junaid Arshad, Amith Rao, Matthew L Repp, Rohit Rao, Clinton Wu, Juanita L Merchant
Gastrointestinal cancers represent one of the more challenging cancers to treat. Current strategies to cure and control gastrointestinal (GI) cancers like surgery, radiation, chemotherapy, and immunotherapy have met with limited success, and research has turned towards further characterizing the tumor microenvironment to develop novel therapeutics. Myeloid-derived suppressor cells (MDSCs) have emerged as crucial drivers of pathogenesis and progression within the tumor microenvironment in GI malignancies. Many MDSCs clinical targets have been defined in preclinical models, that potentially play an integral role in blocking recruitment and expansion, promoting MDSC differentiation into mature myeloid cells, depleting existing MDSCs, altering MDSC metabolic pathways, and directly inhibiting MDSC function...
March 4, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38472645/rethinking-the-consultation-paradigm-validity-evidence-for-a-new-framework-a-multimethods-study
#13
JOURNAL ARTICLE
Rushad Patell, Joséphine A Cool, Elise Merchant, Laura E Dodge, Daniel N Ricotta, Brian Persaud, Larissa K Gomez, Lauren Yang, Alison Trainor, Brian Carney, Jeffrey William, Stewart Lecker, Miranda Theodore, Camille Petri, Douglas Horst, Daniel Stein, Natalia Forbath, Abdul Azim, Andrew J Hale, Jason A Freed
BACKGROUND: In-hospital consultation is essential for patient care. We previously proposed a framework of seven specific consultation types to classify consult requests to improve communication, workflow, and provider satisfaction. METHODS: This multimethods study's aim was to evaluate the applicability of the consult classification framework to real internal medicine (IM) consults. We sought validity evidence using Kane's validity model with focus groups and classifying consult requests from five IM specialties...
March 12, 2024: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://read.qxmd.com/read/38470404/cost-effectiveness-of-pembrolizumab-plus-lenvatinib-compared-with-chemotherapy-for-treating-previously-treated-advanced-endometrial-cancer-in-sweden
#14
JOURNAL ARTICLE
Lewis Ralph, Kate Young, Navneet Upadhyay, Vimalanand Shrikant Prabhu, Christina Ljungcrantz, Rachid Massaad, Ruifeng Xu, Anna Giertz, Adil Merchant, Robert Orlowski, Linda Duska
OBJECTIVE: Pembrolizumab plus lenvatinib was recently approved for the treatment of advanced or recurrent endometrial carcinoma in women with disease progression on or following prior treatment with a platinum‑containing therapy in any setting, and who are not candidates for curative surgery or radiation (KEYNOTE-775/Study-309; NCT03517449). The objective was to assess the cost effectiveness of pembrolizumab plus lenvatinib compared with chemotherapy from a Swedish healthcare perspective...
March 12, 2024: Journal of Medical Economics
https://read.qxmd.com/read/38461183/increasing-employment-opportunity-for-persons-with-spinal-cord-injury-by-digital-working-an-exampling-case-series-from-thailand
#15
JOURNAL ARTICLE
Sintip Pattanakuhar, Urban Schwegler, Paksupa Prommueang, Tuankasfee Hama, Sathapon Patanakuha, Narumon Sumin
INTRODUCTION: Due to activity limitations and physical environmental barriers, low remunerative employment is a challenging issue for people with spinal cord injury (SCI) and relevant rehabilitation personnel. Since work opportunities in digital fields have continued to emerge, this study aims to report and discuss the possibility of using digital working as a strategy for increasing remunerative employment in people with SCI. CASE PRESENTATION: We report live experiences of four people with SCI in Thailand who have digital works with different types of jobs (image segmentation and identification for artificial intelligence development, online merchant, online streamer, cryptocurrency investor), different required digital skills (basic or intermediate digital skills), different employment statuses (employee or owner), and different incomes (from 50 to 200 USD/month)...
March 9, 2024: Spinal Cord Series and Cases
https://read.qxmd.com/read/38457129/perspectives-of-black-patients-on-racism-within-emergency-care
#16
JOURNAL ARTICLE
Anish K Agarwal, Rachel E Gonzales, Charlotte Sagan, Sally Nijim, David A Asch, Raina M Merchant, Eugenia C South
IMPORTANCE: Numerous Black individuals experience racism persistently throughout their lives, with repercussions extending into health care settings. The perspectives of Black individuals regarding emergency department (ED) care, racism, and patient-centered approaches for dismantling structural racism remain less explored. OBJECTIVE: To qualitatively explore the perspectives and experiences of Black patients related to race, racism, and health care following a recent ED visit...
March 1, 2024: JAMA health forum
https://read.qxmd.com/read/38450808/outcomes-of-tricuspid-regurgitation-after-lead-extraction
#17
JOURNAL ARTICLE
Colby Shanafelt, Thomas G Middour, Rand Ibrahim, Miguel Leal, Michael S Lloyd, Anand D Shah, Stacy B Westerman, Mikhael F El-Chami, Faisal M Merchant, Neal K Bhatia
INTRODUCTION: Transvenous leads have been implicated in tricuspid valve (TV) dysfunction, but limited data are available regarding the effect of extracting leads across the TV on valve regurgitation. The aim of this study is to quantify tricuspid regurgitation (TR) before and after lead extraction and identify predictors of worsening TR. METHODS: We studied 321 patients who had echocardiographic data before and after lead extraction. TR was graded on a scale (0 = none/trivial, 1 = mild, 2 = moderate, 3 = severe)...
March 7, 2024: Journal of Cardiovascular Electrophysiology
https://read.qxmd.com/read/38443625/risk-factors-associated-with-medication-administration-errors-in-children-a-prospective-direct-observational-study-of-paediatric-inpatients
#18
JOURNAL ARTICLE
Johanna I Westbrook, Ling Li, Amanda Woods, Tim Badgery-Parker, Virginia Mumford, Alison Merchant, Erin Fitzpatrick, Magdalena Z Raban
INTRODUCTION: Limited evidence exists regarding medication administration errors (MAEs) on general paediatric wards or associated risk factors exists. OBJECTIVE: The aim of this study was to identify nurse, medication, and work-environment factors associated with MAEs among paediatric inpatients. METHODS: This was a prospective, direct observational study of 298 nurses in a paediatric referral hospital in Sydney, Australia. Trained observers recorded details of 5137 doses prepared and administered to 1530 children between 07:00 h and 22:00 h on weekdays and weekends...
March 5, 2024: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://read.qxmd.com/read/38443271/advancing-geriatric-surgical-outcomes-in-elective-ventral-and-incisional-hernia-repair-surgeries-an-american-college-of-surgeons-national-surgical-quality-improvement-program-study
#19
JOURNAL ARTICLE
Alyssa K Greenwood Francis, Natalie N Merchant, Katherine Aguirre, Alonso Andrade
INTRODUCTION: Increasing age is known to be associated with increased risk for postoperative morbidity and mortality, however, the goal of this study was to determine if an increase in age correlates to differences in surgical outcomes for elective ventral hernia repair. METHODS: Retrospective cohort study using American College of Surgeons NSQIP database from 2016 to 2020. Included diagnosis codes were laparoscopic or open incisional or ventral hernia repairs, categorized into three age groups: 18-64y, 65-74y, and ≥75y...
February 23, 2024: American Journal of Surgery
https://read.qxmd.com/read/38442198/undergraduate-medical-education-curriculum-reforms-in-pakistan-a-mixed-methods-study-of-academic-leadership-perspectives
#20
JOURNAL ARTICLE
Saqib Kamran Bakhshi, Noreen Afzal, Asma Altaf Hussain Merchant, Komal Abdul Rahim, Namra Qadeer Shaikh, Ali Aahil Noorali, Maryam Pyar Ali Lakhdir, Muhammad Tariq, Adil H Haider
PURPOSE: Periodic revision of undergraduate medical education (UGME) curricula is an essential part of evidence-based educational practices. Pakistan's national UGME curriculum, last updated in 2005, was reviewed, and recommended updates were made in 2022. The authors explore academic medical school leaders' perspectives about the proposed reforms, gaps within the existing curriculum, and how to ensure the reform implementation is effective, collaborative, and feedback-driven. METHOD: Using a mixed methods approach, data were collected from April-July 2022...
March 5, 2024: Academic Medicine
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