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https://www.readbyqxmd.com/read/28934652/ecophysiological-responses-to-excess-iron-in-lowland-and-upland-rice-cultivars
#1
Caroline Müller, Solange Ferreira da Silveira Silveira, Danilo de Menezes Daloso, Giselle Camargo Mendes, Andrew Merchant, Kacilda Naomi Kuki, Marco Antonio Oliva, Marcelo Ehlers Loureiro, Andréa Miyasaka Almeida
Iron (Fe) is an essential nutrient for plants but under high concentrations, such as that found naturally in clay and waterlogged soils, its toxic effect can limit production. This study aimed to investigate the stress tolerance responses exhibited by different rice cultivars. Both lowland and upland cultivars were grown under excess Fe and hypoxic conditions. Lowland cultivars showed higher Fe accumulation in roots compared with upland cultivars suggesting the use of different strategies to tolerate excess Fe...
September 13, 2017: Chemosphere
https://www.readbyqxmd.com/read/28925934/can-diet-help-non-obese-individuals-with-non-alcoholic-fatty-liver-disease-nafld
#2
Hamid A Merchant
Subjects diagnosed with non-alcoholic fatty liver disease (NAFLD) or hepatic steatosis are usually obese or overweight. NAFLD has also been reported in many non-obese healthy subjects as an incidental finding during imaging. Subjects with early-stage NAFLD who are otherwise healthy are often left unmanaged in current clinical practice; it is not clear if an early intervention in those individuals would be of any benefit in preventing NAFLD progression to more serious conditions. Since many of these subjects are non-alcoholic and have a normal body mass index (BMI), an intensive lifestyle change program is not usually recommended...
September 19, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28922015/over-the-top-acl-reconstruction-plus-extra-articular-lateral-tenodesis-with-hamstring-tendon-grafts-prospective-evaluation-with-20-year-minimum-follow-up
#3
Stefano Zaffagnini, Giulio Maria Marcheggiani Muccioli, Alberto Grassi, Tommaso Roberti di Sarsina, Federico Raggi, Cecilia Signorelli, Francisco Urrizola, Paolo Spinnato, Eugenio Rimondi, Maurilio Marcacci
BACKGROUND: There are few published studies with very long-term follow-up of combined intra- and extra-articular anterior cruciate ligament (ACL) reconstruction. PURPOSE: To analyze clinical and radiographic outcomes of over-the-top ACL reconstruction plus extra-articular lateral tenodesis with autologous hamstrings at minimum 20-year follow-up. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: Of 60 originally eligible patients who underwent over-the-top ACL reconstruction with double-stranded hamstring tendon (leaving intact graft tibial insertions) and extra-articular lateral plasty (performed with the remnant part of tendons), 52 were prospectively evaluated at a minimum 20-year follow-up (mean follow-up, 24 years; 41 men, 11 women; mean age at time of surgery, 25...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28915301/the-work-of-us-public-health-service-officers-in-puerto-rico-1898-1919
#4
Jose G Rigau-Pérez
The history of the US Public Health Service (PHS) is usually presented in terms of diseases or discoveries; this article examines twenty years' activity in one location. When the United States invaded Puerto Rico in 1898, the Marine Hospital Service (now PHS) took responsibility for foreign quarantine, inspection of immigrants, and medical care for merchant seamen. Its officers evaluated the sanitary conditions of port cities, helped reorganize local disease surveillance and control, and investigated endemic diseases (e...
September 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/28903510/changes-in-liver-steatosis-after-switching-from-efavirenz-to-raltegravir-among-human-immunodeficiency-virus-infected-patients-with-nonalcoholic-fatty-liver-disease
#5
Juan Macías, María Mancebo, Dolores Merino, Francisco Téllez, M Luisa Montes-Ramírez, Federico Pulido, Antonio Rivero-Juárez, Miguel Raffo, Montserrat Pérez-Pérez, Nicolás Merchante, Manuel Cotarelo, Juan A Pineda
Background: Antiretroviral drugs with a lower potential to induce hepatic steatosis in human immunodeficiency virus (HIV) infection need to be identified. We compared the effect of switching efavirenz (EFV) to raltegravir (RAL) on hepatic steatosis among HIV-infected patients with nonalcoholic fatty liver disease (NAFLD) receiving EFV plus 2 nucleoside analogues. Methods: HIV-infected patients on EFV plus tenofovir/emtricitabine or abacavir/lamivudine with NAFLD were randomized 1:1 to switch from EFV to RAL (400 mg twice daily), maintaining nucleoside analogues unchanged, or to continue with EFV plus 2 nucleoside analogues...
September 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28894182/the-sinking-of-the-el-faro-predicting-real-world-rogue-waves-during-hurricane-joaquin
#6
Francesco Fedele, Claudio Lugni, Arun Chawla
We present a study on the prediction of rogue waves during the 1-hour sea state of Hurricane Joaquin when the Merchant Vessel El Faro sank east of the Bahamas on October 1, 2015. High-resolution hindcast of hurricane-generated sea states and wave simulations are combined with novel probabilistic models to quantify the likelihood of rogue wave conditions. The data suggests that the El Faro vessel was drifting at an average speed of approximately 2.5 m/s prior to its sinking. As a result, we estimated that the probability that El Faro encounters a rogue wave whose crest height exceeds 14 meters while drifting over a time interval of 10 (50) minutes is ~1/400 (1/130)...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28893547/17%C3%AE-estradiol-modulates-cell-proliferation-of-medullary-cords-during-ovarian-differentiation-of-the-lepidochelys-olivacea-sea-turtle
#7
Verónica Díaz-Hernández, Alma Vázquez-Gómez, Alejandro Marmolejo-Valencia, Luis Manuel Montaño, Horacio Merchant-Larios
In turtles undergoing temperature sex determination (TSD), bipotential gonads express Sox9 in medullary cords at both female- (FPT) and male-producing temperatures (MPT). Subsequently, when the sex fate of medullary cords becomes dimorphic, at FPT, Sox9 is downregulated, whereas at MPT, its expression is maintained. Medullary cords in the ovary turn into ovarian lacuna, whereas in the testis they differentiate as seminiferous cords. When embryos of Lepidochelys olivacea sea turtle are incubated at MPT and treated with estradiol, Sox9 expression persists in the medullary cords in the form of tiny ovotestis-like formations...
September 8, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28892380/gne-781-a-highly-advanced-potent-and-selective-bromodomain-inhibitor-of-cyclic-adenosine-monophosphate-response-element-binding-protein-binding-protein-cbp
#8
F Anthony Romero, Jeremy Murray, Kwong Wah Lai, Vickie Tsui, Brian K Albrecht, Le An, Maureen H Beresini, Gladys de Leon Boenig, Sarah M Bronner, Emily W Chan, Kevin X Chen, Zhongguo Chen, Edna F Choo, Kyle Clagg, Kevin Clark, Terry D Crawford, Patrick Cyr, Denise de Almeida Nagata, Karen E Gascoigne, Jane L Grogan, Georgia Hatzivassiliou, Wei Huang, Thomas L Hunsaker, Susan Kaufman, Stefan G Koenig, Ruina Li, Yingjie Li, Xiaorong Liang, Jiangpeng Liao, Wenfeng Liu, Justin Ly, Jonathan Maher, Colin Masui, Mark Merchant, Yingqing Ran, Alexander M Taylor, John Wai, Fei Wang, Xiaocang Wei, Dong Yu, Bing-Yan Zhu, Xiaoyu Zhu, Steven Magnuson
Inhibition of the bromodomain of the transcriptional regulator CBP/P300 is an especially interesting new therapeutic approach in oncology. We recently disclosed in vivo chemical tool 1 (GNE-272) for the bromodomain of CBP that was moderately potent and selective over BRD4(1). In pursuit of a more potent and selective CBP inhibitor, we used structure-based design. Constraining the aniline of 1 into a tetrahydroquinoline motif maintained potency and increased selectivity 2-fold. Structure-activity relationship studies coupled with further structure-based design targeting the LPF shelf, BC loop, and KAc regions allowed us to significantly increase potency and selectivity, resulting in the identification of non-CNS penetrant 19 (GNE-781, TR-FRET IC50 = 0...
September 21, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28890909/patient-provider-and-system-factors-associated-with-failure-to-follow-up-elevated-glucose-results-in-patients-without-diagnosed-diabetes
#9
Michael E Bowen, Zahra Merchant, Kazeen Abdullah, Deepa Bhat, Jason Fish, Ethan A Halm
BACKGROUND: Although elevated glucose values are strongly associated with undiagnosed diabetes, they are frequently overlooked. Patient, provider, and system factors associated with failure to follow-up elevated glucose values in electronic medical records (EMRs) are not well described. METHODS: We conducted a chart review in a comprehensive EMR with a patient portal and results management features. Established primary care patients with no known diagnosis of diabetes and ≥ 1 glucose value >125 mg/dL were included...
January 2017: Health Services Research and Managerial Epidemiology
https://www.readbyqxmd.com/read/28879057/erratum-clinical-responses-to-erk-inhibition-in-braf-v600e-mutant-colorectal-cancer-predicted-using-a-computational-model
#10
Daniel C Kirouac, Gabriele Schaefer, Jocelyn Chan, Mark Merchant, Christine Orr, Shih-Min A Huang, John Moffat, Lichuan Liu, Kapil Gadkar, Saroja Ramanujan
[This corrects the article DOI: 10.1038/s41540-017-0016-1.].
2017: NPJ Systems Biology and Applications
https://www.readbyqxmd.com/read/28874676/linc-ing-circulating-long-non-coding-rnas-to-the-diagnosis-and-malignant-prediction-of-intraductal-papillary-mucinous-neoplasms-of-the-pancreas
#11
Jennifer B Permuth, Dung-Tsa Chen, Sean J Yoder, Jiannong Li, Andrew T Smith, Jung W Choi, Jongphil Kim, Yoganand Balagurunathan, Kun Jiang, Domenico Coppola, Barbara A Centeno, Jason Klapman, Pam Hodul, Florian A Karreth, Jose G Trevino, Nipun Merchant, Anthony Magliocco, Mokenge P Malafa, Robert Gillies
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease that lacks effective biomarkers for early detection. We hypothesized that circulating long non-coding RNAs (lncRNAs) may act as diagnostic markers of incidentally-detected cystic PDAC precursors known as intraductal papillary mucinous neoplasms (IPMNs) and predictors of their pathology/histological classification. Using NanoString nCounter® technology, we measured the abundance of 28 candidate lncRNAs in pre-operative plasma from a cohort of pathologically-confirmed IPMN cases of various grades of severity and non-diseased controls...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28871996/prognostic-relevance-of-treatment-failure-patterns-in-pediatric-high-grade-glioma-is-there-a-role-for-a-revised-failure-classification-system
#12
John T Lucas, David A Cooper, Scott Hwang, Christopher Tinkle, Xingyu Li, Yimei Li, Brent Orr, Thomas E Merchant, Alberto Broniscer
PURPOSE: We sought to investigate the pattern of treatment failure with respect to anatomic extent, radiation dose, and criteria for failure according to the Response Assessment in Neuro-Oncology (RANO). We evaluated the corresponding prognostic significance of these factors in patients with pediatric high-grade glioma (pHGG). METHODS AND MATERIALS: Fifty-six patients with pHGG were enrolled in an institutional phase 1 to 2 prospective trial that included maximal safe resection and radiation therapy with concurrent and adjuvant erlotinib...
October 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28865835/low-bone-mineral-density-based-on-metacarpal-cortical-bone-area-may-predict-tooth-loss-in-older-men
#13
Anwar T Merchant
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Metacarpal cortical bone area predicts tooth loss in men. Kaye EK, Vokonas P, Garcia RI. JDR Clinical & Translational Research Online 2016;20(10):1-8. SOURCE OF FUNDING: US Department of Veterans Affairs Cooperative Studies Program TYPE OF STUDY/DESIGN: Cohort study.
September 2017: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/28864961/the-effect-of-smoking-on-surgical-outcomes-in-ventral-hernia-repair-a-propensity-score-matched-analysis-of-the-national-surgical-quality-improvement-program-data
#14
N P Borad, A M Merchant
PURPOSE: Although studies have implicated smoking as a positive predictor of post-operative outcomes in inguinal hernia repair, its impact on ventral hernia repair (VHR) is not as clear. This study aims to fill this gap by investigating the impact of smoking on developing adverse 30-day post-operative outcomes in VHR. METHODS: Patients undergoing VHR between 2005 and 2014 were extracted from the American College of Surgeons National Surgical Quality Improvement Program database...
September 1, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28859856/gastrin-induces-nuclear-export-and-proteasome-degradation-of-menin-in-enteric-glial-cells
#15
Sinju Sundaresan, Cameron A Meininger, Anthony J Kang, Amanda L Photenhauer, Michael M Hayes, Nirakar Sahoo, Jolanta Grembecka, Tomasz Cierpicki, Lin Ding, Thomas J Giordano, Tobias Else, David J Madrigal, Malcolm J Low, Fiona Campbell, Ann-Marie Baker, Haoxing Xu, Nicholas A Wright, Juanita L Merchant
BACKGROUND & AIMS: The multiple endocrine neoplasia, type 1 (MEN1) locus encodes the nuclear protein and tumor suppressor menin. MEN1 mutations frequently cause neuroendocrine tumors (NETs) such as gastrinomas, characterized by their predominant duodenal location and local metastasis at time of diagnosis. Diffuse gastrin cell hyperplasia precedes the appearance of MEN1 gastrinomas, which develop within submucosal Brunner's glands. We investigated how menin regulates expression of the gastrin gene and induces generation of submucosal gastrin-expressing cell hyperplasia...
August 28, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28855685/establishment-of-the-most-comprehensive-its2-barcode-database-to-date-of-the-traditional-medicinal-plant-rhodiola-crassulacaee
#16
Ruo-Wei Zhu, Yuan-Cong Li, Da-Lv Zhong, Jian-Qiang Zhang
The roots and rhizomes of Rhodiola crenulata and R. rosea have been used worldwide as adaptogens for hundreds of years. However, rapid growth in demand has resulted in merchants using other species of Rhodiola as adulterants. Here, we surveyed 518 individuals representing 47 of the 55 species in the genus, including 253 R. crenulata individuals from 16 populations and 98 R. rosea individuals from 11 populations, to evaluate the utility of the internal transcribed spacer 2 (ITS2) barcode for identification of Rhodiola species...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28854506/transfusion-related-acute-lung-injury-following-pda-ligation-in-a-preterm-neonate
#17
R G LaGrandeur, M Tran, C Merchant, C Uy
Transfusion-related acute lung injury (TRALI) is a life-threatening complication of blood product transfusion characterized by sudden onset hypoxemic respiratory failure with bilateral lung infiltrates and non-cardiogenic pulmonary edema developing within 6 hours of transfusion. It is believed to be under-recognized, particularly among preterm neonates in whom co-existing developmental lung disease adds diagnostic complexity. Here we report the case of a preterm neonate who developed TRALI during a blood transfusion following PDA ligation...
August 23, 2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28854314/neighborhood-level-disparities-in-resuscitation-and-the-potential-of-connected-health
#18
Raina M Merchant, Peter W Groeneveld
No abstract text is available yet for this article.
August 30, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28842535/journal-impact-brave-new-world
#19
Nancy Eckardt, Sabeeha S Merchant
No abstract text is available yet for this article.
August 25, 2017: Plant Cell
https://www.readbyqxmd.com/read/28841246/facility-level-variation-in-diabetes-and-blood-pressure-control-in-patients-with-diabetes-findings-from-the-veterans-affairs-national-database
#20
Hasan Rehman, Julia M Akeroyd, David Ramsey, Sarah T Ahmed, Anwar T Merchant, Sankar D Navaneethan, Laura A Petersen, Salim S Virani
BACKGROUND: Intensive glycemic and blood pressure (BP) control in diabetic patients is associated with improved cardiovascular outcomes. HYPOTHESIS: We hypothesized that there is suboptimal glycemic and BP control with significant facility-level variation in patients with diabetes. METHODS: We identified patients with diabetes receiving care in 130 facilities in the Veterans Affairs Health Care System. We assessed facility-level rates of glycemic (hemoglobin [Hb]A1c <7%), BP (BP <140/90 mmHg), and combined glycemic and BP control (HbA1c <7% and BP <140/90 mmHg), and their facility-level variation in using median rate ratios (MRR)...
August 25, 2017: Clinical Cardiology
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