keyword
MENU ▼
Read by QxMD icon Read
search

Merchant

keyword
https://www.readbyqxmd.com/read/28721492/peristaltic-like-motion-of-the-human-fetal-right-ventricle-and-its-effects-on-fluid-dynamics-and-energy-dynamics
#1
Hadi Wiputra, Guat Ling Lim, Khong Chun Chua, R Nivetha, Sanah Merchant Soomar, Arijit Biwas, Citra Nurfarah Zaini Mattar, Hwa Liang Leo, Choon Hwai Yap
In both adult human and canine, the cardiac right ventricle (RV) is known to exhibit a peristaltic-like motion, where RV sinus (inflow region) contracts first and the infundibulum (outflow region) later, in a wave-like contraction motion. The delay in contraction between the sinus and infundibulum averaged at 15% of the cardiac cycle and was estimated to produce an intra-ventricular pressure difference of 15 mmHg. However, whether such a contractile motion occurs in human fetuses as well, its effects on hemodynamics remains unknown, and are the subject of the current study...
July 18, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28719383/closed-loop-control-of-total-intravenous-anesthesia-during-significant-intraoperative-blood-loss-a-case-report
#2
Sonia M Brodie, Matthias Görges, J Mark Ansermino, Guy A Dumont, Richard N Merchant
Closed-loop control of anesthesia based on continuous feedback from processed electroencephalography adjusts drug dosing to target a desired depth of hypnosis during dynamic clinical circumstances, freeing the anesthesiologist to focus on more complex tasks. We describe a case of closed-loop control of total intravenous anesthesia in which a sudden loss of blood required immediate intervention. This case illustrates that closed-loop control of drug delivery maintained an appropriate depth of hypnosis during a rapidly changing surgical situation, and that processed electroencephalography may be a useful adjunct indicator for cerebral hypoperfusion...
July 17, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28712688/the-role-of-the-operating-room-in-medical-student-education-differing-perspectives-of-learners-and-educators
#3
Rebecca O'Neill, Michael Shapiro, Aziz Merchant
OBJECTIVE: The surgical clerkship is an integral part of third-year medical student education. The operating room (OR) is a heavily used setting, but it is unclear whether this setting is as effective as possible. To determine the role of the OR and potential improvements, it is necessary to analyze the perspectives of those involved, including surgeons, residents, and medical students. DESIGN: An electronic survey was distributed to the surgeons, surgical residents, and third-year medical students associated with Rutgers New Jersey Medical School...
July 13, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28707260/historical-effects-of-dissolved-organic-carbon-export-and-land-management-decisions-on-the-watershed-scale-forest-carbon-budget-of-a-coastal-british-columbia-douglas-fir-dominated-landscape
#4
B P Smiley, J A Trofymow
BACKGROUND: To address how natural disturbance, forest harvest, and deforestation from reservoir creation affect landscape-level carbon (C) budgets, a retrospective C budget for the 8500 ha Sooke Lake Watershed (SLW) from 1911 to 2012 was developed using historical spatial inventory and disturbance data. To simulate forest C dynamics, data was input into a spatially-explicit version of the Carbon Budget Model-Canadian Forest Sector (CBM-CFS3). Transfers of terrestrial C to inland aquatic environments need to be considered to better capture the watershed scale C balance...
December 2017: Carbon Balance and Management
https://www.readbyqxmd.com/read/28700653/plasma-bradykinin-and-early-diabetic-nephropathy-lesions-in-type-1-diabetes-mellitus
#5
Kevin M Wheelock, Jian Cai, Helen C Looker, Michael L Merchant, Robert G Nelson, Gudeta D Fufaa, E Jennifer Weil, Harold I Feldman, Ramachandran S Vasan, Paul L Kimmel, Brad H Rovin, Michael Mauer, Jon B Klein
OBJECTIVE: To examine the association of bradykinin and related peptides with the development of diabetic nephropathy lesions in 243 participants with type 1 diabetes (T1D) from the Renin-Angiotensin System Study who, at baseline, were normoalbuminuric, normotensive and had normal or increased glomerular filtration rate (GFR). DESIGN: Plasma concentrations of bradykinin and related peptides were measured at baseline by quantitative mass spectrometry. All participants were randomly assigned at baseline to receive placebo, enalapril or losartan during the 5 years between kidney biopsies...
2017: PloS One
https://www.readbyqxmd.com/read/28693794/adiponectin-its-role-in-obesity-associated-colon-and-prostate-cancers
#6
REVIEW
Santoshi Muppala, Siva K P Konduru, Neha Merchant, Judy Ramsoondar, Carlos Karan Rampersad, Balney Rajitha, Vidya Mukund, Jyothsna Kancherla, Anthea Hammond, Tapan Kumar Barik, Mastan Mannarapu, Afroz Alam, Riyaz Basha, Pallaval Veera Bramhachari, Dheeraj Verma, Pinninti Santosh Sushma, Subasini Pattnaik, Ganji Purnachandra Nagaraju
Adipose tissue synthesizes many proteins and hormones collectively called adipokines, which are linked to a number of diseases, including cancer. Low levels of adiponectin are reported to be a risk factor for obesity-related cancers including colorectal and prostate cancers. Accordingly, obesity/lifestyle-related diseases, including certain cancers, may be treated by developing drugs that act specifically on adiponectin levels in circulation. Adiponectin may also serve as a clinical biomarker in obesity-related diseases...
August 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28691552/variations-in-recruitment-yield-and-characteristics-of-participants-recruited-across-diverse-internet-platforms-in-an-hiv-testing-study-of-young-adult-men-who-have-sex-with-men-ymsm
#7
Roland C Merchant, Justin Romanoff, Melissa A Clark, Tao Liu, Joshua G Rosenberger, Jose Bauermeister, Kenneth H Mayer
The Internet is a commonly used medium for recruiting geographically dispersed, smaller populations quickly, such as young adult men-who-have-sex-with-men (YMSM). One approach to improve reach and representativeness is to employ multiple Internet platforms to recruit this hard-to-reach population. The utility of this approach has not been studied adequately, and its impact on the study sample recruited is not yet known. Using data from a study of 18- to 24-year-old HIV-uninfected, Black, Hispanic, and White United States (US) YMSM, this investigation compared advertising and enrollment metrics and participant characteristics of those recruited across Internet platforms...
July 1, 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/28687420/hepatic-adverse-event-profile-of-inotuzumab-ozogamicin-in-adult-patients-with-relapsed-or-refractory-acute-lymphoblastic-leukaemia-results-from-the-open-label-randomised-phase-3-ino-vate-study
#8
Hagop M Kantarjian, Daniel J DeAngelo, Anjali S Advani, Matthias Stelljes, Partow Kebriaei, Ryan D Cassaday, Akil A Merchant, Naohito Fujishima, Toshiki Uchida, Maria Calbacho, Anna A Ejduk, Susan M O'Brien, Elias J Jabbour, Hui Zhang, Barbara J Sleight, Erik R Vandendries, David I Marks
BACKGROUND: The INO-VATE study demonstrated efficacy and safety of inotuzumab ozogamicin versus standard care in adults with relapsed or refractory B-cell acute lymphoblastic leukaemia. Here, we report the frequency of, and potential risk factors for, hepatotoxicity in patients in this trial and after treatment and subsequent haemopoietic stem-cell transplantation (HSCT). METHODS: In this open-label, phase 3, multicentre, international study, adults with relapsed or refractory, CD22-positive, Philadelphia chromosome (Ph)-positive or Ph-negative B-cell acute lymphoblastic leukaemia who were due to receive first or second salvage treatment were randomly assigned (1:1) via an interactive voice response system to receive inotuzumab ozogamicin (starting dose 1·8 mg/m(2) per cycle [0·8 mg/m(2) on day 1; 0·5 mg/m(2) on days 8 and 15 of a 21-28 day cycle for ≤6 cycles]) or standard care (either fludarabine plus cytarabine plus granulocyte colony-stimulating factor, mitoxantrone plus cytarabine, or high-dose cytarabine)...
July 4, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28672168/regulating-cellular-trace-metal-economy-in-algae
#9
REVIEW
Crysten E Blaby-Haas, Sabeeha S Merchant
As indispensable protein cofactors, Fe, Mn, Cu and Zn are at the center of multifaceted acclimation mechanisms that have evolved to ensure extracellular supply meets intracellular demand. Starting with selective transport at the plasma membrane and ending in protein metalation, metal homeostasis in algae involves regulated trafficking of metal ions across membranes, intracellular compartmentalization by proteins and organelles, and metal-sparing/recycling mechanisms to optimize metal-use efficiency. Overlaid on these processes are additional circuits that respond to the metabolic state as well as to the prior metal status of the cell...
June 30, 2017: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/28668135/can-education-influence-stethoscope-hygiene
#10
Jürgen L Holleck, Naseema Merchant, Shin Lin, Shaili Gupta
The importance of stethoscope hygiene has been demonstrated in prior studies, and is acknowledged by guidelines, yet it is rarely done. We implemented a pilot project consisting of provider education, reminder flyers and provision of cleaning supplies at the start of clinical rotations for housestaff, medical students, and attending physicians. Hand hygiene rates did not change significantly with rates between 58% and 63% while stethoscope hygiene remained at zero.
July 1, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28659257/telemedicine-services-for-the-arctic-a-systematic-review
#11
Ashenafi Zebene Woldaregay, Ståle Walderhaug, Gunnar Hartvigsen
BACKGROUND: Telemedicine services have been successfully used in areas where there are adequate infrastructures such as reliable power and communication lines. However, despite the increasing number of merchants and seafarers, maritime and Arctic telemedicine have had limited success. This might be linked with various factors such as lack of good infrastructure, lack of trained onboard personnel, lack of Arctic-enhanced telemedicine equipment, extreme weather conditions, remoteness, and other geographical challenges...
June 28, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/28654794/preclinical-evidence-of-the-anxiolytic-and-sedative-like-activities-of-tagetes-erecta-l-reinforces-its-ethnobotanical-approach
#12
Gimena Pérez-Ortega, Guadalupe Esther Angeles-López, Arturo Argueta-Villamar, María Eva González-Trujano
Morelos State is one of the regions of Mexico where several plant species are used in traditional medicine. Species from Tagetes genus (Asteraceae) are reported as useful in infusion to treat stomachache and intestinal diseases, but also as tranquilizers. In this study, medicinal uses of T. erecta including its depressant effect on the central nervous system (CNS) were explored by interviewing healers and merchants of local markets of Morelos State, and by investigation of the phytochemical and pharmacological tranquilizing properties...
June 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28649441/clinical-responses-to-erk-inhibition-in-braf-v600e-mutant-colorectal-cancer-predicted-using-a-computational-model
#13
Daniel C Kirouac, Gabriele Schaefer, Jocelyn Chan, Mark Merchant, Christine Orr, Shih-Min A Huang, John Moffat, Lichuan Liu, Kapil Gadkar, Saroja Ramanujan
Approximately 10% of colorectal cancers harbor BRAF(V600E) mutations, which constitutively activate the MAPK signaling pathway. We sought to determine whether ERK inhibitor (GDC-0994)-containing regimens may be of clinical benefit to these patients based on data from in vitro (cell line) and in vivo (cell- and patient-derived xenograft) studies of cetuximab (EGFR), vemurafenib (BRAF), cobimetinib (MEK), and GDC-0994 (ERK) combinations. Preclinical data was used to develop a mechanism-based computational model linking cell surface receptor (EGFR) activation, the MAPK signaling pathway, and tumor growth...
2017: NPJ Systems Biology and Applications
https://www.readbyqxmd.com/read/28646229/amplified-surface-temperature-response-of-cold-deep-lakes-to-inter-annual-air-temperature-variability
#14
R Iestyn Woolway, Christopher J Merchant
Summer lake surface water temperatures (LSWTs) have previously been shown to respond more rapidly to climatic warming compared to local summer surface air temperatures (SATs). In a global-scale analysis, we explore the factors underpinning the observation of an amplified response of summer LSWT to SAT variability using 20 years of satellite-derived temperatures from 144 lakes. We demonstrate that the degree of amplification in inter-annual summer LSWT is variable, and is greater for cold lakes (e.g. high latitude and high altitude), which are characterised by a short warming season, and deep lakes, that exhibit long correlation timescales of temperature anomalies due to increased thermal inertia...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28640697/current-clinical-challenges-in-childhood-ependymoma-a-focused-review
#15
Thomas E Merchant
Ependymoma is a locally aggressive tumor with metastatic potential that arises in diverse locations throughout the brain and spine in children. Tumor and treatment may result in significant morbidity. Cure remains elusive for many patients owing to diverse biology and resistance to conventional therapy. The implementation of systematic postoperative irradiation in clinical trials during the past 20 years has increased the proportion of patients achieving durable disease control with excellent results, as measured by objective functional outcome measures...
July 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28637866/endoplasmic-reticulum-mitochondria-junction-is-required-for-iron-homeostasis
#16
Yong Xue, Stefan Schmollinger, Narsis Attar, Oscar Campos, Maria Vogelauer, Michael F Carey, Sabeeha S Merchant, Siavash K Kurdistani
The Endoplasmic Reticulum-Mitochondria Encounter Structure (ERMES) is a protein complex that physically tethers the two organelles to each other and creates the physical basis for communication between them. ERMES functions in lipid and calcium exchange between the ER and mitochondria, protein import into mitochondria and maintenance of mitochondrial morphology and genome. Here we report that ERMES is also required for iron homeostasis. Loss of ERMES components activates an Aft1-dependent iron deficiency response even in iron-replete conditions, leading to accumulation of excess iron inside the cell...
June 21, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28637319/matrix-metalloproteinases-their-functional-role-in-lung-cancer
#17
Neha Merchant, Ganji Purnachandra Nagaraju, Balney Rajitha, Saipriya Lammata, Kishore Kumar Jella, Zachary S Buchwald, Sajani S Lakka, Arif N Ali
Lung malignancy is the foremost cause of cancer-related deaths globally and is frequently related to long-term tobacco smoking. Recent studies reveal that the expression of matrix metalloproteinases (MMPs) is extremely high in lung tumors compared to non-malignant lung tissue. MMPs are zinc-dependent proteases and are involved in the degradation of extracellular matrix (ECM). Several investigations have shown that MMPs manipulate the activity of non-ECM molecules, including cytokines, growth factors and receptors which control the tumor microenvironment...
June 16, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28636971/simulated-long-term-effects-of-varying-tree-retention-on-wood-production-dead-wood-and-carbon-stock-changes
#18
Francesca Santaniello, Line B Djupström, Thomas Ranius, Jan Weslien, Jörgen Rudolphi, Johan Sonesson
Boreal forests are an important source of timber and pulp wood, but provide also other products and services. Utilizing a simulation program and field data from a tree retention experiment in a Scots pine forest in central Sweden, we simulated the consequences during the following 100 years of various levels of retention on production of merchantable wood, dead wood input (as a proxy for biodiversity), and carbon stock changes. At the stand level, wood production decreased with increased retention levels, while dead wood input and carbon stock increased...
June 18, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28636185/decarboxylative-alkynylation
#19
Joel M Smith, Tian Qin, Rohan R Merchant, Jacob T Edwards, Lara R Malins, Zhiqing Liu, Guanda Che, Zichao Shen, Scott A Shaw, Martin D Eastgate, Phil S Baran
The development of a new decarboxylative cross-coupling protocol that affords terminal and substituted alkynes from various carboxylic acids is described using both nickel- and iron-based catalysts. The use of N-hydroxytetrachlorophthalimide (TCNHPI) esters is crucial to the success of the transformation, and the reaction is amenable to in situ carboxylic acid activation. Additionally, an inexpensive, commercially-available alkyne source is employed in this formal homologation process that serves as a surrogate for other well-established alkyne syntheses...
June 21, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28630373/incidence-and-time-course-for-developing-heart-failure-with-high-burden-right-ventricular-pacing
#20
Faisal M Merchant, Michael H Hoskins, Dan L Musat, Julie B Prillinger, Gregory J Roberts, Yelena Nabutovsky, Suneet Mittal
BACKGROUND: Although right ventricular pacing can contribute to cardiomyopathy, the impact of complete atrioventricular block (cAVB) on heart failure (HF) development in pacemaker patients has not been well characterized. We evaluated the incidence and time course for developing HF after pacemaker implantation for cAVB. METHODS AND RESULTS: A MarketScan database identified patients undergoing dual-chamber pacemaker implantation from 2008 to 2014. Patients with cAVB were identified by an atrioventricular node ablation or diagnosis of third-degree AVB...
June 2017: Circulation. Cardiovascular Quality and Outcomes
keyword
keyword
33739
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"