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https://www.readbyqxmd.com/read/28636185/decarboxylative-alkynylation
#1
Joel M Smith, Tian Qin, Rohan R Merchant, Jacob T Edwards, Lara R Malins, Zhiqing Liu, Guanda Che, Zichao Shen, Scott A Shaw, Martin D Eastgate, Phil S Baran
The development of a new decarboxylative cross-coupling protocol that affords terminal and substituted alkynes from various carboxylic acids is described using both nickel- and iron-based catalysts. The use of N-hydroxytetrachlorophthalimide (TCNHPI) esters is crucial to the success of the transformation, and the reaction is amenable to in situ carboxylic acid activation. Additionally, an inexpensive, commercially-available alkyne source is employed in this formal homologation process that serves as a surrogate for other well-established alkyne syntheses...
June 21, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28630373/incidence-and-time-course-for-developing-heart-failure-with-high-burden-right-ventricular-pacing
#2
Faisal M Merchant, Michael H Hoskins, Dan L Musat, Julie B Prillinger, Gregory J Roberts, Yelena Nabutovsky, Suneet Mittal
BACKGROUND: Although right ventricular pacing can contribute to cardiomyopathy, the impact of complete atrioventricular block (cAVB) on heart failure (HF) development in pacemaker patients has not been well characterized. We evaluated the incidence and time course for developing HF after pacemaker implantation for cAVB. METHODS AND RESULTS: A MarketScan database identified patients undergoing dual-chamber pacemaker implantation from 2008 to 2014. Patients with cAVB were identified by an atrioventricular node ablation or diagnosis of third-degree AVB...
June 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28623604/craniospinal-irradiation-for-treatment-of-metastatic-pediatric-low-grade-glioma
#3
Derek S Tsang, Erin S Murphy, Sharon E Ezell, John T Lucas, Christopher Tinkle, Thomas E Merchant
Patients with disseminated pediatric low-grade glioma (LGG) initially treated with chemotherapy frequently experience disease progression, with 5-year event-free survival (EFS) of <20% and 10-year overall survival (OS) of approximately 70%. This study aimed to describe outcomes of metastatic pediatric LGG treated with craniospinal irradiation (CSI). A retrospective study was performed of all patients with metastatic pediatric LGG treated with CSI at a single institution. EFS was defined as survival without disease progression or secondary high-grade glioma...
June 17, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28623152/singapore-healthy-older-people-everyday-hope-study-prevalence-of-frailty-and-associated-factors-in-older-adults
#4
Reshma A Merchant, Matthew Zhixuan Chen, Linda Wei Lin Tan, Moses YiDong Lim, Han Kwee Ho, Rob M van Dam
BACKGROUND: In the context of a rapidly ageing population, Singapore is anticipating a rise in multimorbidity, disability, and dependency, which are driven by physical frailty. Healthy Older People Everyday (HOPE) is an epidemiologic population-based study on community-dwelling older adults aged 65 years and older in Singapore. OBJECTIVE: To investigate the prevalence of frail and prefrail states and their association with polypharmacy, multimorbidity, cognitive and functional status, and perceived health status among community-dwelling older adults in Singapore...
June 13, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28619758/co-targeting-of-mek-and-pdgfr-stat3-pathways-to-treat-pancreaticductal-adenocarcinoma
#5
Nisebita Sahu, Emily Chan, Felix Chu, Thinh Pham, Hartmut Koeppen, William Forrest, Mark Merchant, Jeff Settleman
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal human diseases and remains largely refractory to available drug treatments.  Insufficient targeting of the known oncogenic drivers and activation of compensatory feedback loops and inability to prevent metastatic spread contribute to poor prognosis for this disease. The KRAS-driven MEK pathway is mutationally activated in most pancreatic cancers and is an important target for therapeutics. Using a 2-dimensional monolayer culture system as well as 3-dimensional spheroid culture system, we conducted a screen of a large panel of anti-cancer agents, and found that MEK inhibitors were most effective in targeting PDAC spheroids in comparison to monolayer cultures...
June 15, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28619627/composition-spatial-distribution-and-sources-of-macro-marine-litter-on-the-gulf-of-alicante-seafloor-spanish-mediterranean
#6
Santiago García-Rivera, Jose Luis Sánchez Lizaso, Jose María Bellido Millán
The composition, spatial distribution and source of marine litter in the Spanish Southeast Mediterranean were assessed. The data proceed from a marine litter retention programme implemented by commercial trawlers and were analysed by GIS. By weight, 75.9% was plastic, metal and glass. Glass and plastics were mainly found close to the coast. A high concentration of metal was observed in some isolated zones of both open and coastal waters. Fishing activity was the source of 29.16% of the macro-marine litter, almost 68...
June 12, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28608950/assessment-of-programmed-death-ligand-1-expression-and-tumor-associated-immune-cells-in-pediatric-cancer-tissues
#7
Robbie G Majzner, Jason S Simon, Joseph F Grosso, Daniel Martinez, Bruce R Pawel, Mariarita Santi, Melinda S Merchant, Birgit Geoerger, Imene Hezam, Virginie Marty, Phillippe Vielh, Mads Daugaard, Poul H Sorensen, Crystal L Mackall, John M Maris
BACKGROUND: Programmed death 1 (PD-1) signaling in the tumor microenvironment dampens immune responses to cancer, and blocking this axis induces antitumor effects in several malignancies. Clinical studies of PD-1 blockade are only now being initiated in pediatric patients, and little is known regarding programmed death-ligand 1 (PD-L1) expression in common childhood cancers. The authors characterized PD-L1 expression and tumor-associated immune cells (TAICs) (lymphocytes and macrophages) in common pediatric cancers...
June 13, 2017: Cancer
https://www.readbyqxmd.com/read/28608155/pathophysiology-of-gastric-nets-role-of-gastrin-and-menin
#8
REVIEW
Sinju Sundaresan, Anthony J Kang, Juanita L Merchant
PURPOSE OF REVIEW: Neuroendocrine tumors (NETs) were initially identified as a separate entity in the early 1900s as a unique malignancy that secretes bioactive amines. GI-NETs are the most frequent type and represent a unique subset of NETs, because at least 75% of these tumors represent gastrin stimulation of the enterochromaffin-like cell located in the body of the stomach. The purpose of this review is to understand the specific role of gastrin in the generation of Gastric NETs (G-NETs)...
July 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28600916/corrigendum-to-low-dose-ouabain-stimulates-na-k-atpase-%C3%A3-alpha%C3%A3-1-subunit-association-with-angiotensin-ii-type-1-receptor-in-renal-proximal-tubule-cells-biochim-biophys-acta-1863-11-2016-2624-2636
#9
Corey J Ketchem, Clayton D Conner, Rebecca D Murray, Madalyn DuPlessis, Eleanor D Lederer, Daniel Wilkey, Michael Merchant, Syed J Khundmiri
No abstract text is available yet for this article.
June 7, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28584970/morphometric-evaluation-of-facial-and-vestibulocochlear-nerves-using-magnetic-resonance-imaging-comparison-of-meni%C3%A3-re-s-disease-ears-with-normal-hearing-ears
#10
Annika Henneberger, Birgit Ertl-Wagner, Maximilian Reiser, Robert Gürkov, Wilhelm Flatz
Loss of neural structures (such as hair cells or neurones within the spiral ganglion) has been proposed to be involved in Menière's disease (MD) (Spoendlin et al. Acta oto-laryngologica Supplementum 499:1-21, 1; Merchant et al. Eur Arch Oto-Rhino-Laryngol Off J Eur Feder Oto-Rhino-Laryngol Soc (EUFOS) Affil German Soc Oto-Rhino-Laryngol Head Neck Surg 252(2):63-75, 2; Tsuji et al. Ann Otol Rhinol Laryngol Suppl 81:26-31, 3; Kariya, Otol Neurotol Off Publ Am Otol Soc Am Neurotol Soc Eur Acad Otol Neurotol 28(8):1063-1068, 4; Megerian Laryngoscope 115(9):1525-1535, 5) but this has yet to be confirmed...
June 5, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28583846/epigenetic-effects-of-inhibition-of-heat-shock-protein-90-hsp90-in-human-pancreatic-and-colon-cancer
#11
Ganji Purnachandra Nagaraju, Christina Wu, Neha Merchant, Zhengjia Chen, Gregory B Lesinski, Bassel F El-Rayes
Silencing of tumor suppressor and DNA repair genes through methylation plays a role in cancer development, growth and response to therapy in colorectal and pancreatic cancers. Heat shock protein 90 (HSP90) regulates transcription of DNA methyltransferase enzymes (DNMT). In addition, DNMTs are client proteins of HSP90. The aim of this study is to evaluate the effects of HSP90 inhibition on DNA methylation in colorectal and pancreatic cancer cell lines. Our data shows that inhibition of HSP90 using ganetespib resulted in downregulation of mRNA and protein expression of DNMT1, DNMT3A, and DNMT3B in HT-29 and MIA PaCa-2 cell lines...
June 3, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28583825/a-summary-of-the-2016-james-w-freston-conference-of-the-american-gastroenterological-association-intestinal-metaplasia-in-the-esophagus-and-stomach-origins-differences-similarities-and-significance
#12
Stuart J Spechler, Juanita L Merchant, Timothy C Wang, Parakrama Chandrasoma, James G Fox, Robert M Genta, James R Goldenring, Yoku Hayakawa, Ernst J Kuipers, Pauline K Lund, Frank McKeon, Jason Mills, Robert D Odze, Richard M Peek, Thai Pham, Jianwen Que, Anil K Rustgi, Nicholas J Shaheen, Ramesh A Shivdasani, Rhonda Souza, Peter Storz, Andrea Todisco, David H Wang, Nicholas A Wright
No abstract text is available yet for this article.
June 2, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28556566/select-human-cancer-mutants-of-nrmt1-alter-its-catalytic-activity-and-decrease-n-terminal-trimethylation
#13
Kaitlyn M Shields, John G Tooley, Janusz J Petkowski, Daniel W Wilkey, Nichola C Garbett, Michael L Merchant, Alan Cheng, Christine E Schaner Tooley
A subset of B-cell lymphoma patients have dominant mutations in the histone H3 lysine 27 (H3K27) methyltransferase EZH2, which change it from a monomethylase to a trimethylase. These mutations occur in aromatic resides surrounding the active site and increase growth and alter transcription. We study the N-terminal trimethylase NRMT1 and the N-terminal monomethylase NRMT2. They are 50% identical, but differ in key aromatic residues in their active site. Given how these residues affect EZH2 activity, we tested whether they are responsible for the distinct catalytic activities of NRMT1/2...
May 27, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28550905/socioeconomic-factors-and-mortality-in-emergency-general-surgery-trends-over-a-20-year-period
#14
Sarah J Armenia, Sri Ram Pentakota, Aziz M Merchant
BACKGROUND: Socioeconomic factors such as race, insurance, and income quartiles have been identified as independent risk factors in emergency general surgery (EGS), but this impact has not been studied over time. We sought to identify trends in disparities in EGS-related operative mortality over a 20-y period. METHODS: The National Inpatient Sample was used to identify patient encounters coded for EGS in 1993, 2003, and 2013. Logistic regression models were used to examine the adjusted relationship between race, primary payer status, and median income quartiles and in-hospital mortality after adjusting for patients' age, gender, Elixhauser comorbidity score, and hospital region, size, and location-cum-teaching status...
May 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28549703/integrated-care-enhancing-the-role-of-the-primary-health-care-professional-in-preventing-functional-decline-a-systematic-review
#15
REVIEW
John E Morley, Hidenori Arai, Li Cao, Birong Dong, Reshma A Merchant, Bruno Vellas, Renuka Visvanathan, Jean Woo
BACKGROUND: Although the older population is increasing worldwide, there is a marked deficit in the number of persons trained in geriatrics. It is now recognized that early detection and treatment of geriatric syndromes (frailty, sarcopenia, anorexia of aging, and cognitive decline) will delay or avert the development of disability. OBJECTIVES: To identify simple screening programs available for primary health professionals to identify geriatric syndromes. DATA SOURCES: PubMed for the last 5 years and study authors...
June 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28542978/procedural-outcomes-and-long-term-survival-following-lead-extraction-in-octogenarians
#16
Mikhael F El-Chami, Michael N Sayegh, Adarsh Patel, Jad El-Khalil, Yaanik Desai, Angel R Leon, Faisal M Merchant
BACKGROUND: Octogenarians account for a significant percentage of patients with indwelling pacemakers or defibrillators. OBJECTIVES: To determine procedural outcomes and long-term survival after Lead Extraction (LE) in octogenarians. METHODS: We retrospectively identified all patients who underwent defibrillator or pacemaker LE at our institution between January 1(st) 2007 and May 31(st) 2016. Patients were stratified based on age into two groups: < 80 years old (Group 1, n = 674) or ≥ 80 (Group 2, n = 100)...
May 24, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28540667/neurocognitive-functioning-in-pediatric-craniopharyngioma-performance-before-treatment-with-proton-therapy
#17
Ashley S Fournier-Goodnight, Jason M Ashford, Thomas E Merchant, Frederick A Boop, Daniel J Indelicato, Lei Wang, Hui Zhang, Heather M Conklin
The goal of this study was to investigate the impact of patient-, disease-, and treatment-related variables upon neurocognitive outcomes in pediatric patients with craniopharyngioma prior to treatment with proton therapy or observation after radical resection. For all participants (N = 104), relevant clinical and demographic variables were attained and neurocognitive evaluations completed prior to irradiation or planned observation. One-sample t-tests were conducted to compare performance to published normative data...
May 24, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28540562/comparison-of-home-based-oral-fluid-rapid-hiv-self-testing-versus-mail-in-blood-sample-collection-or-medical-community-hiv-testing-by-young-adult-black-hispanic-and-white-msm-results-from-a-randomized-trial
#18
Roland C Merchant, Melissa A Clark, Tao Liu, Justin Romanoff, Joshua G Rosenberger, Jose Bauermeister, Kenneth H Mayer
We aimed to determine in a randomized trial if young adult black, Hispanic, and white men-who-have-sex-with-men (YMSM) are more likely to complete home-based oral fluid rapid HIV self-testing than either mail-in blood sample collection or medical facility/community organization-based HIV testing. Stratified by race/ethnicity, participants were randomly assigned to use a free oral fluid rapid HIV self-test (n = 142), a free mail-in blood sample collection HIV test (n = 142), or be tested at a medical facility/community organization of their choice (n = 141)...
May 24, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28532779/meta-analysis-of-risk-of-ventricular-arrhythmias-after-improvement-in-left-ventricular-ejection-fraction-during-follow-up-in-patients-with-primary-prevention-implantable-cardioverter-defibrillators
#19
Aiman Smer, Alok Saurav, Muhammad Soubhi Azzouz, Mohsin Salih, Mohamed Ayan, Ahmed Abuzaid, Abhilash Akinapelli, Arun Kanmanthareddy, Lynda E Rosenfeld, Faisal M Merchant, Hussam Abuissa
Implantable cardioverter defibrillators (ICDs) reduce the risk of sudden cardiac death in patients with impaired left ventricular ejection fraction (LVEF). However, there are limited data on the long-term benefit of ICD therapy in patients whose LVEF subsequently improves. We conducted a meta-analysis to evaluate the effect of LVEF improvement on ICD therapy during follow-up. Incidence rate ratios (IRRs) with 95% confidence intervals (CIs) were calculated using random-effects modeling. Sixteen studies with 3,959 patients were included in our analysis...
July 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28532194/cost-effectiveness-of-ceftolozane-tazobactam-plus-metronidazole-compared-with-piperacillin-tazobactam-as-empiric-therapy-for-the-treatment-of-complicated-intra-abdominal-infections-based-on-the-in-vitro-surveillance-of-bacterial-isolates-in-the-uk
#20
Vimalanand Prabhu, Jason Foo, Harblas Ahir, Eric Sarpong, Sanjay Merchant
AIMS: An increase in the prevalence of antimicrobial resistance among gram-negative pathogens has been noted recently. A challenge in empiric treatment of complicated intra-abdominal infection (cIAI) is identifying initial appropriate antibiotic therapy, which is associated with reduced length of stay and mortality compared with inappropriate therapy. The objective of this study was to assess the cost-effectiveness of ceftolozane/tazobactam + metronidazole compared with piperacillin/tazobactam (commonly used in this indication) in the treatment of patients with cIAI in UK hospitals...
June 8, 2017: Journal of Medical Economics
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