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https://www.readbyqxmd.com/read/29351120/grading-using-ki-67-index-and-mitotic-rate-increases-the-prognostic-accuracy-of-pancreatic-neuroendocrine-tumors
#1
Prejesh Philips, David A Kooby, Shishir Maithel, Nipun B Merchant, Sharon M Weber, Emily R Winslow, Syed Ahmad, Hong J Kim, Charles R Scoggins, Kelly M McMasters, Robert C G Martin
OBJECTIVES: To measure the usefulness of Ki-67 proliferative index (Ki-67 index) as a prognostic variable for grading pancreatic neuroendocrine tumors. METHODS: A multi-institutional prospective database comprising 350 patients. Grading based on mitotic activity (<2 mitoses/10 high-power fields, 2-20 and >20) and Ki-67 index (<3% per 10 high-power fields, 3%-20% and >20%). Final grade selected based on higher grade of either variable. RESULTS: Most patients were in the less than 3% (n = 158) and 3% to 20% Ki-67 category (n = 107), with a minority being high-grade (Ki-67 > 20%, n = 27)...
January 18, 2018: Pancreas
https://www.readbyqxmd.com/read/29332187/human-bite-injuries-to-the-head-and-neck-current-trends-and-management-protocols-in-england-and-wales
#2
Glyndwr W Jenkins, Robert Isaac, Shakir Mustafa
INTRODUCTION: Human bite injuries can be challenging in their presentation to the examining physician. In a study by Merchant et al., 18% of patients presenting with a human bite injury had suffered wounds to the head and neck region. Current trends in their initial management at presentation to emergency departments throughout England and Wales will be discussed in this paper. MATERIALS AND METHOD: A postal survey was sent out to 100 A&E lead clinicians. This was followed up by telephone enquiries to improve the response rate...
January 14, 2018: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29330398/management-of-important-adverse-events-associated-with-inotuzumab-ozogamicin-expert-panel-review
#3
Partow Kebriaei, Corey Cutler, Marcos de Lima, Sergio Giralt, Stephanie J Lee, David Marks, Akil Merchant, Wendy Stock, Koen van Besien, Matthias Stelljes
No abstract text is available yet for this article.
January 12, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29325975/procedural-outcomes-and-long-term-survival-associated-with-lead-extraction-in-patients-with-abandoned-leads
#4
Faisal M Merchant, Thor Tejada, Adarsh Patel, Jad El-Khalil, Yaanik Desai, Brent Keeling, Omar M Lattouf, Angel R Leon, Mikhael F El-Chami
BACKGROUND: The decision to abandon or extract superfluous sterile leads is controversial. OBJECTIVE: To compare procedural outcomes and long-term survival of patients with and without abandoned leads undergoing lead extraction (LE). METHODS: Retrospective review of all patients undergoing transvenous LE at our institution from Jan. 2007 to May 2016. Patients were stratified into two groups based on the presence (Group 1) or absence (Group 2) of abandoned leads...
January 8, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29316848/integrated-wearable-and-self-carrying-active-upper-limb-orthosis
#5
Roberto Merchant, David Cruz-Ortiz, Mariana Ballesteros-Escamilla, Isaac Chairez
The aim of this study was to develop a prototype of an orthotic system that can be used as a support tool in the rehabilitation of the upper limb. The construction of this device was motivated by the increasing number of subjects suffering from full or partial loss of the upper limb function as a consequence of spinal cord injuries, strokes, occupational syndromes and sports injuries. The majority of procedures used in upper limb rehabilitation consist of repetitive movements enforced by physiotherapists; a robotic device executing the same tasks seems to be a plausible solution if the orthosis can be programmed and controlled automatically...
January 1, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29311051/relationship-between-state-level-google-online-search-volume-and-cancer-incidence-in-the-united-states-retrospective-study
#6
Charles A Phillips, Allison Barz Leahy, Yimei Li, Marilyn M Schapira, L Charles Bailey, Raina M Merchant
BACKGROUND: In the United States, cancer is common, with high morbidity and mortality; cancer incidence varies between states. Online searches reflect public awareness, which could be driven by the underlying regional cancer epidemiology. OBJECTIVE: The objective of our study was to characterize the relationship between cancer incidence and online Google search volumes in the United States for 6 common cancers. A secondary objective was to evaluate the association of search activity with cancer-related public events and celebrity news coverage...
January 8, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29305428/thank-you-editors-and-reviewers-of-the-plant-cell
#7
EDITORIAL
Nancy A Eckardt, Sabeeha S Merchant
No abstract text is available yet for this article.
December 2017: Plant Cell
https://www.readbyqxmd.com/read/29301833/establishing-a-preclinical-multidisciplinary-board-for-brain-tumors
#8
Birgit Nimmervoll, Nidal Boulos, Brandon M Bianski, Jason Dapper, Michael DeCuypere, Anang A Shelat, Sabrina Terranova, Hope Elizabeth Terhune, Amar Gajjar, Yogesh T Patel, Burgess B Freeman, Arzu Onar-Thomas, Clinton F Stewart, Martine F Roussel, R Kiplin Guy, Thomas E Merchant, Christopher Calabrese, Karen D Wright, Richard J Gilbertson
PURPOSE: Curing all children with brain tumors will require an understanding of how each subtype responds to conventional treatments and how best to combine existing and novel therapies.  It is extremely challenging to acquire this knowledge in the clinic alone, especially among patients with rare tumors.  Therefore, we developed a preclinical brain tumor platform to test combinations of conventional and novel therapies in a manner that closely recapitulates clinic trials.  Experimental Design: A multidisciplinary team was established to design and conduct neurosurgical, fractionated radiotherapy and chemotherapy studies, alone or in combination, in accurate mouse models of supratentorial ependymoma (SEP) subtypes and choroid plexus carcinoma (CPC)...
January 4, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29296810/ephb4-is-a-therapeutic-target-in-aml-and-promotes-leukemia-cell-survival-via-akt
#9
Akil A Merchant, Aparna Jorapur, Amy McManus, Ren Liu, Valery Krasnoperov, Parvesh Chaudhry, Mohan Singh, Lisa Harton, Mary Agajanian, Miriam Kim, Timothy J Triche, Brian J Druker, Jeffrey W Tyner, Parkash S Gill
EPHB4, an ephrin type B receptor, is implicated in the growth of several epithelial tumors and is a promising target in cancer therapy; however, little is known about its role in hematologic malignancies. In this article, we show that EPHB4 is highly expressed in ∼30% of acute myeloid leukemia (AML) samples. In an unbiased RNA interference screen of primary leukemia samples, we found that EPHB4 drives survival in a subset of AML cases. Knockdown of EPHB4 inhibits phosphatidylinositol 3-kinase/AKT signaling, and this is accompanied by a reduction in cell viability, which can be rescued by a constitutively active form of AKT...
September 12, 2017: Blood Advances
https://www.readbyqxmd.com/read/29280458/radiation-therapy-for-optic-pathway-and-hypothalamic-low-grade-gliomas-in-children
#10
Derek S Tsang, Erin S Murphy, Thomas E Merchant
PURPOSE: The long-term survival of pediatric patients with optic pathway or hypothalamic low-grade glioma (LGG) who receive radiation therapy (RT) has not been previously assessed. METHODS AND MATERIALS: A retrospective study was performed of all patients with optic-hypothalamic pediatric LGG treated with RT at a single institution. Eligible patients were aged ≤21 years at the time of RT and had localized LGG diagnosed by neuroimaging or histology. The median RT dose was 54 Gy, delivered in 30 fractions...
November 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29276751/indian-hedgehog-suppresses-intestinal-inflammation
#11
EDITORIAL
Nataliya Razumilava, Deborah L Gumucio, Linda C Samuelson, Yatrik M Shah, Asma Nusrat, Juanita L Merchant
No abstract text is available yet for this article.
2018: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29242380/insights-into-the-proteome-of-gastrointestinal-stromal-tumors-derived-exosomes-reveals-new-potential-diagnostic-biomarkers
#12
Safinur Atay, Daniel W Wilkey, Mohammed M Milhem, Michael Merchant, Andrew K Godwin
Developing tumors continuously release nano-sized vesicles that represent circulating "fingerprints" of the tumor's identity.  In gastrointestinal stromal tumor (GIST), we have previously reported that these tumors release "oncosomes" carrying the constitutively activated tyrosine kinase (TK) receptor KIT.  Despite the clinical utility of TK inhibitors, such as imatinib mesylate (IM), recurrence and metastasis are clinical problems that urge the need to identify new tumor-derived molecules.  To this aim, we performed the first high quality proteomic study of GIST-derived exosomes (GDEs) and identified 1,060 proteins composing the core GDE proteome (cGDEp)...
December 14, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29235746/clinical-problem-solving-a-tobacco-merchant-who-can-t-spit
#13
Sandra Benizri, Nancy Agmon-Levin, Noam D Kitrey, Dan Carter, Elinor Goshen, Yehonathan Sharabi
A 47 year old man presented with a combination of dry mouth and lightheadedness while standing. His medical background was unremarkable except for cigarette smoking and hyperlipidemia. Sjögren's syndrome was ruled out, and he was referred for evaluation of orthostatic hypotension, which by then included syncopal episodes and injuries. Additional symptoms included dry eyes, constipation, reduced sweating, and erectile dysfunction. After excluding medications and structural cardiac abnormalities as causes of orthostatic hypotension, a clinical autonomic evaluation was performed...
December 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29234230/traumatic-eye-ball-luxation-a-stepwise-approach-to-globe-salvage
#14
Himika Gupta, Srivalli Natarajan, Sushrut Vaidya, Shipra Gupta, Dinesh Shah, Raj Merchant, Shrikant Deshpande
Craniofacial trauma is often associated with orbital and ocular injuries. We report a case of a 21-year-old male with motor vehicular accident, orbital roof blow-in fracture, cerebrospinal fluid (CSF) leak, and left sided globe luxation with corneal abrasion and complete conjunctival denuding. The patient was managed by a multispeciality team and the eyeball was protected by amniotic membrane graft (AMG) biological dressing with novel use of inverted sterile metallic bowl as mechanical protection till the patient stabilized...
October 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29229328/outcomes-after-reirradiation-for-recurrent-pediatric-intracranial-ependymoma
#15
Derek S Tsang, Elizabeth Burghen, Paul Klimo, Frederick A Boop, David W Ellison, Thomas E Merchant
PURPOSE: To determine the long-term outcomes and the optimal dose and volume for reirradiation of recurrent pediatric ependymoma. METHODS AND MATERIALS: Patients with recurrent ependymoma treated with a second course of fractionated radiation therapy (RT2) were reviewed retrospectively. Eligible patients had localized, intracranial ependymoma at initial diagnosis that was treated with focal radiation (RT1) without craniospinal irradiation (CSI) and were aged ≤21 years at the time of RT2...
October 13, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29212231/zbp-89-function-in-colonic-stem-cells-and-during-butyrate-induced-senescence
#16
Ramon Ocadiz-Ruiz, Amanda L Photenhauer, Michael M Hayes, Lin Ding, Eric R Fearon, Juanita L Merchant
ZBP-89 (Zfp148, ZNF148) is a Kruppel-type zinc-finger family transcription factor that binds to GC-rich DNA elements. Earlier studies in cell lines demonstrated that ZBP-89 cooperates with Wnt β-catenin signaling by inducing β-catenin gene expression. Since β-catenin levels are normally highest at the crypt base, we examined whether ZBP-89 is required for stem cell maintenance. Lineage-tracing using a Zfp148CreERT2 transgenic line demonstrated expression in both intestine and colonic stem cells. Deleting the Zfp148 locus in the colon using the Cdx2NLSCreERT2 transgene, reduced the size and number of polyps formed in the Apc-deleted mice...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29210791/design-and-evaluation-of-a-closed-loop-anesthesia-system-with-robust-control-and-safety-system
#17
Nicholas West, Klaske van Heusden, Matthias Görges, Sonia Brodie, Aryannah Rollinson, Christian L Petersen, Guy A Dumont, J Mark Ansermino, Richard N Merchant
BACKGROUND: Closed-loop control of anesthesia involves continual adjustment of drug infusion rates according to measured clinical effect. The NeuroSENSE monitor provides an electroencephalographic measure of depth of hypnosis (wavelet-based anesthetic value for central nervous system monitoring [WAVCNS]). It has previously been used as feedback for closed-loop control of propofol, in a system designed using robust control engineering principles, which implements features specifically designed to ensure patient safety...
November 22, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29194854/vessel-noise-cuts-down-communication-space-for-vocalising-fish-and-marine-mammals
#18
R L Putland, N D Merchant, A Farcas, C A Radford
Anthropogenic noise across the world's oceans threatens the ability of vocalising marine species to communicate. Some species vocalise at key life stages or whilst foraging, and disruption to the acoustic habitat at these times could lead to adverse consequences at the population level. To investigate the risk of these impacts, we investigated the effect of vessel noise on the communication space of the Bryde's whale Balaenoptera edeni, an endangered species which vocalises at low frequencies, and bigeye Pempheris adspersa, a nocturnal fish species which uses contact calls to maintain group cohesion while foraging...
November 30, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29194695/a-grounded-theory-study-of-how-couples-desist-from-intimate-partner-violence
#19
Lisa V Merchant, Jason B Whiting
Intimate partner violence is a common and damaging experience for many couples, and therapists struggle to address it adequately (Johnson, 2008). Despite its negative effects, many violent couples stay together, with some stopping their violent behaviors. Unfortunately, we know little about the systemic factors affecting violence desistance. This study used grounded theory methods to analyze the process of desistance in formerly violent couples. A model of desistance consisting of three categories was developed, which for most couples included a (a) Turning Point, (b) Decision to Change, and (c) Doing Things Differently...
December 1, 2017: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/29192170/monkeys-share-the-neurophysiological-basis-for-encoding-sound-periodicities-captured-by-the-frequency-following-response-with-humans
#20
Yaneri A Ayala, Alexandre Lehmann, Hugo Merchant
The extraction and encoding of acoustical temporal regularities are fundamental for human cognitive auditory abilities such as speech or beat entrainment. Because the comparison of the neural sensitivity to temporal regularities between human and animals is fundamental to relate non-invasive measures of auditory processing to their neuronal basis, here we compared the neural representation of auditory periodicities between human and non-human primates by measuring scalp-recorded frequency-following response (FFR)...
November 30, 2017: Scientific Reports
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