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https://www.readbyqxmd.com/read/28542978/procedural-outcomes-and-long-term-survival-following-lead-extraction-in-octogenarians
#1
Mikhael F El-Chami, Michael N Sayegh, Adarsh Patel, Jad El-Khalil, Yaanik Desai, Angel R Leon, Faisal M Merchant
BACKGROUND: Octogenarians account for a significant percentage of patients with indwelling pacemakers or defibrillators. OBJECTIVES: To determine procedural outcomes and long-term survival after Lead Extraction (LE) in octogenarians. METHODS: We retrospectively identified all patients who underwent defibrillator or pacemaker LE at our institution between January 1(st) 2007 and May 31(st) 2016. Patients were stratified based on age into two groups: < 80 years old (Group 1, n = 674) or ≥ 80 (Group 2, n = 100)...
May 24, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28540667/neurocognitive-functioning-in-pediatric-craniopharyngioma-performance-before-treatment-with-proton-therapy
#2
Ashley S Fournier-Goodnight, Jason M Ashford, Thomas E Merchant, Frederick A Boop, Daniel J Indelicato, Lei Wang, Hui Zhang, Heather M Conklin
The goal of this study was to investigate the impact of patient-, disease-, and treatment-related variables upon neurocognitive outcomes in pediatric patients with craniopharyngioma prior to treatment with proton therapy or observation after radical resection. For all participants (N = 104), relevant clinical and demographic variables were attained and neurocognitive evaluations completed prior to irradiation or planned observation. One-sample t-tests were conducted to compare performance to published normative data...
May 24, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28540562/comparison-of-home-based-oral-fluid-rapid-hiv-self-testing-versus-mail-in-blood-sample-collection-or-medical-community-hiv-testing-by-young-adult-black-hispanic-and-white-msm-results-from-a-randomized-trial
#3
Roland C Merchant, Melissa A Clark, Tao Liu, Justin Romanoff, Joshua G Rosenberger, Jose Bauermeister, Kenneth H Mayer
We aimed to determine in a randomized trial if young adult black, Hispanic, and white men-who-have-sex-with-men (YMSM) are more likely to complete home-based oral fluid rapid HIV self-testing than either mail-in blood sample collection or medical facility/community organization-based HIV testing. Stratified by race/ethnicity, participants were randomly assigned to use a free oral fluid rapid HIV self-test (n = 142), a free mail-in blood sample collection HIV test (n = 142), or be tested at a medical facility/community organization of their choice (n = 141)...
May 24, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28532779/meta-analysis-of-risk-of-ventricular-arrhythmias-after-improvement-in-left-ventricular-ejection-fraction-during-follow-up-in-patients-with-primary-prevention-implantable-cardioverter-defibrillators
#4
Aiman Smer, Alok Saurav, Muhammad Soubhi Azzouz, Mohsin Salih, Mohamed Ayan, Ahmed Abuzaid, Abhilash Akinapelli, Arun Kanmanthareddy, Lynda E Rosenfeld, Faisal M Merchant, Hussam Abuissa
Implantable cardioverter defibrillators (ICDs) reduce the risk of sudden cardiac death in patients with impaired left ventricular ejection fraction (LVEF). However, there are limited data on the long-term benefit of ICD therapy in patients whose LVEF subsequently improves. We conducted a meta-analysis to evaluate the effect of LVEF improvement on ICD therapy during follow-up. Incidence rate ratios (IRRs) with 95% confidence intervals (CIs) were calculated using random-effects modeling. Sixteen studies with 3,959 patients were included in our analysis...
April 27, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28532194/cost-effectiveness-of-ceftolozane-tazobactam-plus-metronidazole-compared-with-piperacillin-tazobactam-as-empiric-therapy-for-the-treatment-of-complicated-intra-abdominal-infections-based-on-the-in-vitro-surveillance-of-bacterial-isolates-in-the-uk
#5
Vimalanand Prabhu, Jason Foo, Harblas Ahir, Eric Sarpong, Sanjay Merchant
AIMS: An increase in the prevalence of antimicrobial resistance among gram-negative pathogens has been noted recently.[1] A challenge in empiric treatment of complicated intra-abdominal infection (cIAI) is identifying initial appropriate antibiotic therapy, which is associated with reduced length of stay and mortality compared with inappropriate therapy. The objective of this study was to assess the cost-effectiveness of ceftolozane/tazobactam+metronidazole compared with piperacillin/tazobactam (commonly used in this indication) in the treatment of patients with cIAI in United Kingdom (UK) hospitals...
May 22, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28529303/social-perception-of-infertility-and-its-treatment-in-late-medieval-italy-margherita-datini-an-italian-merchant-s-wife
#6
Jong Kuk Nam
Because the perception of infertility in medieval Europe ranged from the extremely religious view of it as a malediction of God or the devil's work, to the reasonable medical conception of it as a sort of disease to treat, it is very difficult to determine the general attitudes of ordinary people towards infertility. This article seeks to elucidate the common social perception of infertility and its treatment in late medieval Europe by analyzing the case of Margherita Datini, an Italian merchant's wife who lived in the 1400s...
December 2016: Ŭi Sahak
https://www.readbyqxmd.com/read/28528965/probing-the-timing-network-a-continuous-theta-burst-stimulation-study-of-temporal-categorization
#7
Juan Carlos Méndez, Lorenzo Rocchi, Marjan Jahanshahi, John Rothwell, Hugo Merchant
Time perception in the milliseconds and seconds ranges is thought to be processed by different neural mechanisms. However, whether there is a sharp boundary between these ranges and whether they are implemented in the same, overlapped or separate brain areas is still not certain. To probe the role of the right dorsolateral prefrontal cortex (dlPFC), the right supplementary motor area (SMA), and the cerebellum on time perception, we temporarily altered their activity on healthy volunteers on separate sessions using transcranial magnetic stimulation with the continuous Theta Burst Stimulation (cTBS) protocol...
May 18, 2017: Neuroscience
https://www.readbyqxmd.com/read/28525778/inferior-vena-cava-collapsibility-detects-fluid-responsiveness-among-spontaneously-breathing-critically-ill-patients
#8
Keith A Corl, Naomi R George, Justin Romanoff, Andrew T Levinson, Darin B Chheng, Roland C Merchant, Mitchell M Levy, Anthony M Napoli
PURPOSE: Measurement of inferior vena cava collapsibility (cIVC) by point-of-care ultrasound (POCUS) has been proposed as a viable, non-invasive means of assessing fluid responsiveness. We aimed to determine the ability of cIVC to identify patients who will respond to additional intravenous fluid (IVF) administration among spontaneously breathing critically-ill patients. METHODS: Prospective observational trial of spontaneously breathing critically-ill patients...
May 12, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28515088/loss-of-nherf-1-expression-prevents-dopamine-mediated-na-k-atpase-regulation-in-renal-proximal-tubule-cells-from-rat-models-of-hypertension-aged-f344-and-shrs
#9
Michelle T Barati, Corey J Ketchem, Michael L Merchant, Walter B Kusiak, Pedro A Jose, Edward J Weinman, Amanda J LeBlanc, Eleanor D Lederer, Syed J Khundmiri
Dopamine decreases Na-K ATPase (NKA) activity by PKC-dependent phosphorylation and endocytosis of the NKA alpha1. Dopamine-mediated regulation of NKA is impaired in aging and some forms of hypertension. Using opossum (OK) proximal tubule cells (PTCs), we demonstrated that sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) associates with NKA alpha1 and dopamine-1 receptor (D1R). This association is required for the dopamine-mediated regulation of NKA. In OK cells dopamine decreases NHERF-1 association with NKA alpha1 but increases its association with D1R...
May 17, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28513435/a-bioactive-peptide-amidating-enzyme-is-required-for-ciliogenesis
#10
Dhivya Kumar, Daniela Strenkert, Ramila S Patel-King, Michael T Leonard, Sabeeha S Merchant, Richard E Mains, Stephen M King, Betty A Eipper
The pathways controlling cilium biogenesis in different cell types have not been fully elucidated. We recently identified peptidylglycine α-amidating monooxygenase (PAM), an enzyme required for generating amidated bioactive signaling peptides, in Chlamydomonas and mammalian cilia. Here, we show that PAM is required for the normal assembly of motile and primary cilia in Chlamydomonas, planaria and mice. Chlamydomonas PAM knockdown lines failed to assemble cilia beyond the transition zone, had abnormal Golgi architecture and altered levels of cilia assembly components...
May 17, 2017: ELife
https://www.readbyqxmd.com/read/28510267/the-jack-wills-crowd-towards-a-sociology-of-an-elite-subculture
#11
Anthony King, Daniel Smith
British sociologists have long been interested in youth sub-cultures. However British sociologists have tended to focus on working class subcultures and avoided engagement with exclusive sub-cultures of elite social groups. This article seeks to attend to this gap by examining the subculture of a British elite: ex-public school students at select universities in the UK in the twenty-first century. This group consists of a relatively small group of young adults, aged between 18 and 23, who attended public schools, especially one of the nine Clarendon schools (Eton, Winchester, Westminster, St...
May 16, 2017: British Journal of Sociology
https://www.readbyqxmd.com/read/28504290/effect-of-body-deformability-on-microswimming
#12
Jayant Pande, Laura Merchant, Timm Krüger, Jens Harting, Ana-Sunčana Smith
In this work we consider the following question: given a mechanical microswimming mechanism, does increased deformability of the swimmer body hinder or promote the motility of the swimmer? To answer this we run immersed-boundary-lattice-Boltzmann simulations of a microswimmer composed of deformable beads connected with springs. We find that the same deformations in the beads can result in different effects on the swimming velocity, namely an enhancement or a reduction, depending on the other parameters. To understand this we determine analytically the velocity of the swimmer, starting from the forces driving the motion and assuming that the deformations in the beads are known as functions of time and are much smaller than the beads themselves...
May 15, 2017: Soft Matter
https://www.readbyqxmd.com/read/28495809/comparison-of-enteral-versus-intravenous-potassium-supplementation-in-hypokalaemia-in-paediatric-patients-in-intensive-care-post-cardiac-surgery-open-label-randomised-equivalence-trial-eips
#13
Naveed Ur Rehman Siddiqu, Quratulain Merchant, Babar S Hasan, Arjumand Rizvi, Muneer Amanullah, Amina Rehmat, Anwarul Ul Haq
OBJECTIVES: The primary objective was to compare the efficacy of enteral potassium replacement (EPR) and intravenous potassium replacement (IVPR) as first-line therapy. Secondary objectives included comparison of adverse effects and number of doses required to resolve the episode of hypokalaemia. TRIAL DESIGN: The EIPS trial is designed as a randomised, equivalence trial between two treatment arms. STUDY SETTING: The study was conducted at the paediatric cardiac intensive care unit (PCICU) at Aga Khan University Hospital, Karachi...
May 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28487292/gli3-repressor-determines-hedgehog-pathway-activation-and-is-required-for-response-to-smo-antagonist-glasdegib-in-aml
#14
Parvesh Chaudhry, Mohan Singh, Timothy J Triche, Monica Guzman, Akil A Merchant
The Hedgehog (Hh) signaling pathway is activated in many cancers and is a promising target for therapeutic development. Deletions in the receptor Patched (PTCH) or activating mutations in Smoothened (SMO) have been reported in basal cell carcinoma (BCC) and medulloblastoma, but are largely absent in most tumor types; therefore, the mechanism of pathway activation in most cancers, including hematological malignancies, remains unknown. In normal tissues, Hh pathway activation via PTCH/SMO causes an increase in the downstream transcriptional activator GLI1 and a decrease in the transcriptional repressor GLI3R...
May 9, 2017: Blood
https://www.readbyqxmd.com/read/28486355/air-abrasive-disinfection-of-implant-surfaces-in-a-simulated-model-of-periimplantitis
#15
David George Quintero, Robert Bonnie Taylor, Matthew Braden Miller, Keith Roshanali Merchant, Scott Anthony Pasieta
INTRODUCTION: This in vitro study aimed to evaluate the ability of air-powder abrasion to decontaminate dental implants. MATERIALS AND METHODS: Twenty-six implants were inoculated with a Streptococcus sanguinis biofilm media in a novel periimplantitis defect model. Six implants served as controls, and 20 implants were disinfected with either the Cavitron JET Plus or the AIR-FLOW PERIO air-powder abrasion units. Residual bacteria were cultured, and colony forming units (CFUs) were totaled at 24 hours...
May 6, 2017: Implant Dentistry
https://www.readbyqxmd.com/read/28486130/gastric-acid-secretion-from-parietal-cells-is-mediated-by-a-ca-2-efflux-channel-in-the-tubulovesicle
#16
Nirakar Sahoo, Mingxue Gu, Xiaoli Zhang, Neel Raval, Junsheng Yang, Michael Bekier, Raul Calvo, Samarjit Patnaik, Wuyang Wang, Greyson King, Mohammad Samie, Qiong Gao, Sasmita Sahoo, Sinju Sundaresan, Theresa M Keeley, Yanzhuang Wang, Juan Marugan, Marc Ferrer, Linda C Samuelson, Juanita L Merchant, Haoxing Xu
Gastric acid secretion by parietal cells requires trafficking and exocytosis of H/K-ATPase-rich tubulovesicles (TVs) toward apical membranes in response to histamine stimulation via cyclic AMP elevation. Here, we found that TRPML1 (ML1), a protein that is mutated in type IV mucolipidosis (ML-IV), is a tubulovesicular channel essential for TV exocytosis and acid secretion. Whereas ML-IV patients are reportedly achlorhydric, transgenic overexpression of ML1 in mouse parietal cells induced constitutive acid secretion...
May 8, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28484037/chromosome-level-genome-assembly-and-transcriptome-of-the-green-alga-chromochloris-zofingiensis-illuminates-astaxanthin-production
#17
Melissa S Roth, Shawn J Cokus, Sean D Gallaher, Andreas Walter, David Lopez, Erika Erickson, Benjamin Endelman, Daniel Westcott, Carolyn A Larabell, Sabeeha S Merchant, Matteo Pellegrini, Krishna K Niyogi
Microalgae have potential to help meet energy and food demands without exacerbating environmental problems. There is interest in the unicellular green alga Chromochloris zofingiensis, because it produces lipids for biofuels and a highly valuable carotenoid nutraceutical, astaxanthin. To advance understanding of its biology and facilitate commercial development, we present a C. zofingiensis chromosome-level nuclear genome, organelle genomes, and transcriptome from diverse growth conditions. The assembly, derived from a combination of short- and long-read sequencing in conjunction with optical mapping, revealed a compact genome of ∼58 Mbp distributed over 19 chromosomes containing 15,274 predicted protein-coding genes...
May 8, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28481630/changes-in-the-buccolingual-inclination-of-first-molars-with-growth-in-untreated-subjects-a-longitudinal-study
#18
Bhavendrasinh Sayania, Mehreen Merchant, Philip Josephs, Chun-Hsi Chung
OBJECTIVES: To assess longitudinal changes in the buccolingual inclination of the maxillary and mandibular first molars in untreated male and female subjects. MATERIALS AND METHODS: Forty-seven male and 48 female subjects whose longitudinal dental casts were available at ages 6-16 years, with normal maxillary and mandibular arch forms were included. The original casts at ages 6, 7, 8, 9, 10, 12, 14, and 16 years were digitized and standardized. Measurements were recorded as the differences in cusp heights in the vertical dimension for the mandibular and maxillary first molars using OrthoInsight software...
May 8, 2017: Angle Orthodontist
https://www.readbyqxmd.com/read/28471949/oncological-challenges-for-an-ageing-population-living-with-hiv
#19
Alessia Dalla Pria, Shairoz Merchant, Mark Bower
: Improvements in survival and changing patterns of transmission mean that the population of people living with HIV (PLWH) is ageing. Increasing age is a risk factor for many varieties of cancer, including most non-AIDS-defining malignancies. Moreover, the premature ageing described in PLWH and the development of cancer share many molecular features. As a consequence, there has been a dramatic increase in the number of PLWH who are diagnosed with cancer. The treatment of older HIV-positive patients with cancer requires careful attention to details...
June 1, 2017: AIDS
https://www.readbyqxmd.com/read/28458464/algae-as-nutritional-and-functional-food-sources-revisiting-our-understanding
#20
REVIEW
Mark L Wells, Philippe Potin, James S Craigie, John A Raven, Sabeeha S Merchant, Katherine E Helliwell, Alison G Smith, Mary Ellen Camire, Susan H Brawley
Global demand for macroalgal and microalgal foods is growing, and algae are increasingly being consumed for functional benefits beyond the traditional considerations of nutrition and health. There is substantial evidence for the health benefits of algal-derived food products, but there remain considerable challenges in quantifying these benefits, as well as possible adverse effects. First, there is a limited understanding of nutritional composition across algal species, geographical regions, and seasons, all of which can substantially affect their dietary value...
2017: Journal of Applied Phycology
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