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https://www.readbyqxmd.com/read/28106230/the-value-of-serial-metal-ion-levels-in-following-up-patients-with-metal-on-metal-hip-arthroplasty
#1
Gavin McHugh, Rajiv Merchant, Gabrielle E Kelly, Karen M Bergin, Gerald F McCoy, Andrew P Wozniak, John F Quinlan
BACKGROUND: The sensitivity of cobalt (Co) and chromium (Cr) ion-levels in detecting poorly performing metal-on-metal hip implants is low. This study proposes that serial changes in ion-levels are a more accurate marker of arthroplasties at risk. METHODS: Serial metal ion-levels and implant data of 285 patients with ASR resurfacing or replacement were studied. Patient and implant characteristics were analysed using univariate and multivariate analyses. RESULTS: 111 (39%) had revision surgery...
January 20, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28096297/frontline-science-tumor-necrosis-factor-%C3%AE-stimulation-and-priming-of-human-neutrophil-granule-exocytosis
#2
Kenneth R McLeish, Michael L Merchant, T Michael Creed, Shweta Tandon, Michelle T Barati, Silvia M Uriarte, Richard A Ward
Neutrophil granule exocytosis plays an important role in innate and adaptive immune responses. The present study examined TNF-α stimulation or priming of exocytosis of the 4 neutrophil granule subsets. TNF-α stimulated exocytosis of secretory vesicles and gelatinase granules and primed specific and azurophilic granule exocytosis to fMLF stimulation. Both stimulation and priming of exocytosis by TNF-α were dependent on p38 MAPK activity. Bioinformatic analysis of 1115 neutrophil proteins identified by mass spectrometry as being phosphorylated by TNF-α exposure found that actin cytoskeleton regulation was a major biologic function...
January 17, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28092325/persistent-pain-after-motor-vehicle-collision-comparative-effectiveness-of-opioids-vs-nonsteroidal-antiinflammatory-drugs-prescribed-from-the-emergency-department-a-propensity-matched-analysis
#3
Francesca L Beaudoin, Roee Gutman, Roland C Merchant, Melissa A Clark, Robert A Swor, Jeffrey S Jones, David C Lee, David A Peak, Robert M Domeier, Niels K Rathlev, Samuel A McLean
Each year millions of Americans present to the emergency department (ED) for care after a motor vehicle collision (MVC); the majority (>90%) are discharged to home after evaluation. Acute musculoskeletal pain is the norm in this population, and such patients are typically discharged to home with prescriptions for oral opioid analgesics or nonsteroidal antiinflammatory drugs (NSAIDs). The influence of acute pain management on subsequent pain outcomes in this common ED population is unknown. We evaluated the effect of opioid analgesics vs NSAIDs initiated from the ED on the presence of moderate to severe musculoskeletal pain and ongoing opioid use at 6 weeks in a large cohort of adult ED patients presenting to the ED after MVC (n = 948)...
February 2017: Pain
https://www.readbyqxmd.com/read/28092023/white-matter-alterations-in-college-football-players-a-longitudinal-diffusion-tensor-imaging-study
#4
Michael Christian Mayinger, Kian Merchant-Borna, Jakob Hufschmidt, Marc Muehlmann, Isabelle Ruth Weir, Boris-Stephan Rauchmann, Martha Elizabeth Shenton, Inga Katharina Koerte, Jeffrey John Bazarian
The aim of this study was to evaluate longitudinal changes in the diffusion characteristics of brain white matter (WM) in collegiate athletes at three time points: prior to the start of the football season (T1), after one season of football (T2), followed by six months of no-contact rest (T3). Fifteen male collegiate football players and 5 male non-athlete student controls underwent diffusion MR imaging and computerized cognitive testing at all three timepoints. Whole-brain tract-based spatial statistics (TBSS) were used to compare fractional anisotropy (FA), radial diffusivity (RD), axial diffusivity (AD), and trace between all timepoints...
January 14, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28088598/are-the-current-guidelines-for-the-surgical-management-of-intraductal-papillary-mucinous-neoplasms-of-the-pancreas-adequate-a-multi-institutional-study
#5
Gregory C Wilson, Shishir K Maithel, David Bentrem, Daniel E Abbott, Sharon Weber, Clifford Cho, Robert Cg Martin, Charles R Scoggins, Hong Jin Kim, Nipun B Merchant, David A Kooby, Michael J Edwards, Syed A Ahmad
BACKGROUND: Controversy persists regarding the management of patients with IPMN. International consensus guidelines stratify patients into high risk, worrisome, and low risk categories. STUDY DESIGN: The medical records of 7 institutions were reviewed for patients that underwent surgical management of IPMN between 2000-2015. RESULTS: 324 patients were included in the analysis. 60.4% of patients had main-duct / mixed type, and 39.7% had branch-duct IPMN...
January 11, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28078638/-11-c-methionine-positron-emission-tomography-delineates-non-contrast-enhancing-tumor-regions-at-high-risk-for-recurrence-in-pediatric-high-grade-glioma
#6
John T Lucas, Nick Serrano, Hyun Kim, Xingyu Li, Scott E Snyder, Scott Hwang, Yimei Li, Chia-Ho Hua, Alberto Broniscer, Thomas E Merchant, Barry L Shulkin
We assessed the prognostic utility of (11)C-Methionine positron emission tomography (MET-PET) in pediatric high-grade glioma (HGG). Thirty-one children had 62 MET-PET studies. Segmented tumor volumes from co-registered magnetic resonance studies were assessed for concordance with MET-PET uptake using Boolean operations. The tumor volume at diagnosis and treatment failure was assessed relative to MET-PET avid volume. The prognostic impact of MET-PET-delineated non-contrast enhancing tumor (NCET) was assessed...
January 11, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28069077/successful-obliteration-of-troublesome-and-chronically-draining-cavities
#7
S Geerse, F A Ebbens, M J F de Wolf, E van Spronsen
OBJECTIVE: This study aimed to evaluate the results of revision radical cavity surgery with mastoid obliteration using a standardised grading scheme. METHODS: A retrospective study was performed of 121 patients (122 ears) with chronically draining ears who underwent revision radical cavity surgery with mastoid obliteration between 2007 and 2013. Surgical indications, patient characteristics, pre- and post-operative Merchant grade, and surgical outcomes were recorded...
January 10, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28065887/procedural-outcomes-and-long-term-survival-following-trans-venous-defibrillator-lead-extraction-in-patients-with-end-stage-renal-disease
#8
Anand D Shah, Lakshmi P Peddareddy, Maher A Addish, Kimberly Kelly, Adarsh U Patel, Mary Casey, Abhinav Goyal, Angel R Leon, Mikhael F El-Chami, Faisal M Merchant
AIMS: End-stage renal disease (ESRD) increases the risk of implantable cardioverter-defibrillator (ICD) infection. We sought to define outcomes of lead extraction in patients with ESRD. METHODS AND RESULTS: Implantable cardioverter-defibrillator lead extractions at our institution from January 2006 to March 2014 were stratified by absence (Control-Ex, n = 465) or presence (ESRD-Ex, n = 43) of ESRD. Procedural outcomes and survival were determined by medical records review...
January 8, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28062722/acute-plasma-tau-relates-to-prolonged-return-to-play-after-concussion
#9
Jessica Gill, Kian Merchant-Borna, Andreas Jeromin, Whitney Livingston, Jeffrey Bazarian
OBJECTIVE: To determine whether tau changes after sport-related concussion (SRC) relate to return to play (RTP). METHODS: Collegiate athletes underwent preseason plasma sampling and cognitive testing and were followed. After a SRC (n = 46), athletes and controls (n = 37) had sampling at 6 hours, and at 24 hours, 72 hours, and 7 days after SRC. A sample of 21 nonathlete controls were compared at baseline. SRC athletes were grouped by long (>10 days, n = 23) and short (≤10 days, n = 18) RTP...
January 6, 2017: Neurology
https://www.readbyqxmd.com/read/28062663/a-population-based-analysis-of-germline-bap1-mutations-in-melanoma
#10
Sally J O'Shea, Carla Daniela Robles-Espinoza, Lauren McLellan, Jeanine Harrigan, Xavier Jacq, James Hewinson, Vivek Iyer, Will Merchant, Faye Elliott, Mark Harland, D Timothy Bishop, Julia Newton-Bishop, David J Adams
Germline mutation of the BRCA1 associated protein-1 (BAP1) gene has been linked to uveal melanoma, mesothelioma, meningioma, renal cell carcinoma and basal cell carcinoma. Germline variants have also been found in familial cutaneous melanoma pedigrees, but their contribution to sporadic melanoma has not been fully assessed. We sequenced BAP1 in 1,977 melanoma cases and 754 controls and used deubiquitinase assays, a pedigree analysis, and a histopathological review to assess the consequences of the mutations found...
January 5, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28062392/variations-in-facebook-posting-patterns-across-validated-patient-health-conditions-a-prospective-cohort-study
#11
Robert J Smith, Patrick Crutchley, H Andrew Schwartz, Lyle Ungar, Frances Shofer, Kevin A Padrez, Raina M Merchant
BACKGROUND: Social media is emerging as an insightful platform for studying health. To develop targeted health interventions involving social media, we sought to identify the patient demographic and disease predictors of frequency of posting on Facebook. OBJECTIVE: The aims were to explore the language topics correlated with frequency of social media use across a cohort of social media users within a health care setting, evaluate the differences in the quantity of social media postings across individuals with different disease diagnoses, and determine if patients could accurately predict their own levels of social media engagement...
January 6, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28060581/face-to-face-and-online-networks-college-students-experiences-in-a-weight-loss-trial
#12
Gina Merchant, Nadir Weibel, Laura Pina, William G Griswold, James H Fowler, Guadalupe X Ayala, Linda C Gallo, James Hollan, Kevin Patrick
This study aimed to understand how college students participating in a 2-year randomized controlled trial (Project SMART: Social and Mobile Approach to Reduce Weight; N = 404) engaged their social networks and used social and mobile technologies to try and lose weight. Participants in the present study (n = 20 treatment, n = 18 control) were approached after a measurement visit and administered semi-structured interviews. Interviews were analyzed using principles from grounded theory. Treatment group participants appreciated the timely support provided by the study and the integration of content across multiple technologies...
January 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28058516/applying-and-advancing-behavior-change-theories-and-techniques-in-the-context-of-a-digital-health-revolution-proposals-for-more-effectively-realizing-untapped-potential
#13
Arlen C Moller, Gina Merchant, David E Conroy, Robert West, Eric Hekler, Kari C Kugler, Susan Michie
As more behavioral health interventions move from traditional to digital platforms, the application of evidence-based theories and techniques may be doubly advantageous. First, it can expedite digital health intervention development, improving efficacy, and increasing reach. Second, moving behavioral health interventions to digital platforms presents researchers with novel (potentially paradigm shifting) opportunities for advancing theories and techniques. In particular, the potential for technology to revolutionize theory refinement is made possible by leveraging the proliferation of "real-time" objective measurement and "big data" commonly generated and stored by digital platforms...
January 5, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28048604/tu-fg-brb-11-design-and-evaluation-of-a-robotic-c-arm-cbct-system-for-image-guided-proton-therapy
#14
C Hua, W Yao, T Kidani, J Farr, K Tomida, S Ozawa, T Nishimura, T Fujusawa, R Shinagawa, T Merchant
PURPOSE: To describe the design and performance of a ceiling-mounted robotic C-arm CBCT system for image-guided proton therapy. METHODS: Uniquely different from traditional C-arm CBCT used in interventional radiology, the imaging system was designed to provide volumetric image guidance for patients treated on a 190-degree proton gantry system and a 6 degree-of-freedom (DOF) robotic patient positioner. The mounting of robotic arms to the ceiling rails, rather than gantry or nozzle, provides the flexibility in imaging locations (isocenter, iso+27cm in X, iso+100cm in Y) in the room and easier upgrade as technology advances...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048096/su-f-j-205-effect-of-cone-beam-factor-on-cone-beam-ct-number-accuracy
#15
W Yao, C Hua, J Farr, S Brady, T Merchant
PURPOSE: To examine the suitability of a Catphan™ 700 phantom for image quality QA of a cone beam computed tomography (CBCT) system deployed for proton therapy. METHODS: Catphan phantoms, particularly Catphan™ 504, are commonly used in image quality QA for CBCT. As a newer product, Catphan™ 700 offers more tissue equivalent inserts which may be useful for generating the electron density - CT number curve for CBCT based treatment planning. The sensitometry-and-geometry module used in Catphan™ 700 is located at the end of the phantom and after the resolution line pair module...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047673/su-d-207a-06-pediatric-abdominal-organ-motion-quantified-via-a-novel-4d-mri-method
#16
J Uh, M J Krasin, J T Lucas, C Tinkle, T E Merchant, C Hua
PURPOSE: To develop a 4D MRI method for assessing respiration-induced abdominal organ motion in children receiving radiation therapy. METHODS: A 4D MRI using internal image-based respiratory surrogate has been developed and implemented on a clinical scanner (1.5T Siemens Avanto). Ten patients (younger group: N=6, 2-5 years, anesthetized; older group: N=4, 11-15 years) with neuroblastoma, Wilm's tumor rhabdomyosarcoma, or desmoplastic small round cell tumor received free breathing 4D MRI scans for treatment planning...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047554/su-f-i-09-improvement-of-image-registration-using-total-variation-based-noise-reduction-algorithms-for-low-dose-cbct
#17
S Mukherjee, J Farr, T Merchant, W Yao
PURPOSE: To study the effect of total-variation based noise reduction algorithms to improve the image registration of low-dose CBCT for patient positioning in radiation therapy. METHODS: In low-dose CBCT, the reconstructed image is degraded by excessive quantum noise. In this study, we developed a total-variation based noise reduction algorithm and studied the effect of the algorithm on noise reduction and image registration accuracy. To study the effect of noise reduction, we have calculated the peak signal-to-noise ratio (PSNR)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045310/neural-systems-for-reflected-and-direct-self-appraisals-in-chinese-young-adults-exploring-the-role-of-the-temporal-parietal-junction
#18
Jennifer H Pfeifer, Caitlin E V Mahy, Junaid S Merchant, Chunhui Chen, Carrie L Masten, Andrew J Fuligni, Matthew D Lieberman, Jared Lessard, Qi Dong, Chuansheng Chen
OBJECTIVES: Although cortical midline structures (CMS) are the most commonly identified neural foundations of self-appraisals, research is beginning to implicate the temporal-parietal junction (TPJ) in more interdependent self-construals. The goal of this study was to extend this research in an understudied population by (a) examining both direct (first-person) and reflected (third-person) self-appraisals across 2 domains (social and academics), and (b) exploring individual differences in recruitment of the TPJ during reflected self-appraisals...
January 2017: Cultural Diversity & Ethnic Minority Psychology
https://www.readbyqxmd.com/read/28035785/the-hepatic-matrisome-responds-dynamically-to-injury-characterization-of-transitional-changes-to-the-extracellular-matrix-in-mice
#19
Veronica L Massey, Christine E Dolin, Lauren G Poole, Shanice V Hudson, Deanna L Siow, Guy N Brock, Michael L Merchant, Daniel W Wilkey, Gavin E Arteel
: The extracellular matrix (ECM) consists of diverse components that work bidirectionally with surrounding cells to create a responsive microenvironment. In some contexts (e.g., hepatic fibrosis), changes to the ECM are well recognized and understood. However, it is becoming increasingly accepted that the hepatic ECM proteome (i.e., matrisome) responds dynamically to stress well before fibrosis. The term "transitional tissue remodeling" describes qualitative and quantitative ECM changes in response to injury that do not alter the overall architecture of the organ; these changes in ECM may contribute to early disease initiation and/or progression...
November 5, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28035125/crimes-against-public-health-in-croatia-and-bosnia-and-herzegovina
#20
Maja Buhovac
The criminal protection of human health, public health is based on the punishment procedures doctor, pharmacist, ordinary citizen, manufacturers and merchants. It is justified to singleout these crimes in a special group of criminal offenses within the particular part, which is particularly true for those offenses where the focus is not on false threats to the health of a particular individual, but when it may lead to more people lose their lives or get to poor health of more people. This paper will point out the fundamental characteristics of these criminal offenses, their justification to identify a separate chapter in the criminal law, the importance of respect ethical standards in scientific activity, the criminal liability of doctors as fundamental carriers of health activities with regard to the offenses for which the perpetrators appear primary doctor...
December 2016: Psychiatria Danubina
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