keyword
https://read.qxmd.com/read/38534986/papillary-thyroid-cancer-trends-in-the-wake-of-the-covid-19-pandemic-is-there-a-shift-toward-a-more-aggressive-entity
#21
JOURNAL ARTICLE
Iyad Hassan, Lina Hassan, Farooq Bacha, Mohammad Al Salameh, Omran Gatee, Wiam Hassan
BACKGROUND: Globally, the incidence of papillary thyroid cancer (PTC) has been increasing over the last few decades and it has become the second most common cancer in women in the UAE. There is some evidence to suggest that COVID-19 infection might be directly linked to the development of aggressive variants of PTC. The primary goal of this study was to compare the clinical and pathologic characteristics of thyroid cancer patients treated at the largest endocrine surgery center in Abu Dhabi before and after the COVID-19 pandemic outbreak...
March 20, 2024: Diseases (Basel)
https://read.qxmd.com/read/38534854/review-of-spider-silk-applications-in-biomedical-and-tissue-engineering
#22
REVIEW
Marija Branković, Fatima Zivic, Nenad Grujovic, Ivan Stojadinovic, Strahinja Milenkovic, Nikola Kotorcevic
This review will present the latest research related to the production and application of spider silk and silk-based materials in reconstructive and regenerative medicine and tissue engineering, with a focus on musculoskeletal tissues, and including skin regeneration and tissue repair of bone and cartilage, ligaments, muscle tissue, peripheral nerves, and artificial blood vessels. Natural spider silk synthesis is reviewed, and the further recombinant production of spider silk proteins. Research insights into possible spider silk structures, like fibers (1D), coatings (2D), and 3D constructs, including porous structures, hydrogels, and organ-on-chip designs, have been reviewed considering a design of bioactive materials for smart medical implants and drug delivery systems...
March 11, 2024: Biomimetics
https://read.qxmd.com/read/38534844/sporopollenin-capsules-as-biomimetic-templates-for-the-synthesis-of-hydroxyapatite-and-%C3%AE-tcp
#23
JOURNAL ARTICLE
Arianna De Mori, Daniel Quizon, Hannah Dalton, Berzah Yavuzyegit, Guido Cerri, Milan Antonijevic, Marta Roldo
Pollen grains, with their resilient sporopollenin exine and defined morphologies, have been explored as bio-templates for the synthesis of calcium phosphate minerals, particularly hydroxyapatite (HAp) and β-tricalcium phosphate (TCP). Various pollen morphologies from different plant species (black alder, dandelion, lamb's quarters, ragweed, and stargazer lily) were evaluated. Pollen grains underwent acid washing to remove allergenic material and facilitate subsequent calcification. Ragweed and lamb's quarter pollen grains were chosen as templates for calcium phosphate salts deposition due to their distinct morphologies...
March 4, 2024: Biomimetics
https://read.qxmd.com/read/38534828/bioactive-hydroxyapatite-aerogels-with-piezoelectric-particles
#24
JOURNAL ARTICLE
Catarina Tavares, Tânia Vieira, Jorge C Silva, João P M R Borges, M Carmo Lança
Open-cell foams based on hydroxyapatite (HAp) can mimic the extracellular matrix (ECM) to better replace damaged hard tissues and assist in their regeneration processes. Aerogels of HAp nanowires (NW) with barium titanate (BT) particles were produced and characterized regarding their physical and chemical properties, bioactivity, and in vitro cytotoxicity. Considering the role of piezoelectricity (mainly due to collagen) and surface charges in bone remodeling, all BT particles, of size 280 nm and 2 and 3 µm, contained BaTiO3 in their piezoelectric tetragonal phase...
February 27, 2024: Biomimetics
https://read.qxmd.com/read/38534529/femtosecond-laser-cutting-of-human-crystalline-lens-capsule-and-decellularization-for-corneal-endothelial-bioengineering
#25
JOURNAL ARTICLE
Olfa Ben Moussa, Louise Parveau, Inès Aouimeur, Grégory Egaud, Corantin Maurin, Sofiane Fraine, Sébastien Urbaniak, Chantal Perrache, Zhiguo He, Sedao Xxx, Oliver Dorado Cortez, Sylvain Poinard, Cyril Mauclair, Philippe Gain, Gilles Thuret
The bioengineering of corneal endothelial grafts consists of seeding in vitro cultured corneal endothelial cells onto a thin, transparent, biocompatible, and sufficiently robust carrier which can withstand surgical manipulations. This is one of the most realistic alternatives to donor corneas, which are in chronic global shortage. The anterior capsule of the crystalline lens has already been identified as one of the best possible carriers, but its challenging manual preparation has limited its use. In this study, we describe a femtosecond laser cutting process of the anterior capsule of whole lenses in order to obtain capsule discs of 8 mm diameter, similar to conventional endothelial grafts...
March 5, 2024: Bioengineering
https://read.qxmd.com/read/38534342/a-recombinant-peptide-device-combined-with-adipose-tissue-derived-stem-cells-enhances-subcutaneous-islet-engraftment
#26
JOURNAL ARTICLE
Takahiro Mizui, Akiko Inagaki, Yasuhiro Nakamura, Takehiro Imura, Satomi Suzuki Uematsu, Shigehito Miyagi, Takashi Kamei, Michiaki Unno, Kimiko Watanabe, Masafumi Goto
Subcutaneous space has been considered an attractive site for islet graft transplantation; however, the oxygen tension and vascularization are insufficient for islet graft survival. We investigated whether subcutaneous pre-implantation of a recombinant peptide (RCP) device with adipose tissue-derived stem cells (ADSCs) enhanced subcutaneous islet engraftment. RCP devices with/without syngeneic ADSCs were pre-implanted into the subcutaneous space of C57BL/6 mice. Syngeneic islets (300 or 120 islet equivalents (IEQs)) were transplanted into the pre-treated space after diabetes induction using streptozotocin...
March 13, 2024: Cells
https://read.qxmd.com/read/38534216/the-epidemiology-and-management-of-clostridioides-difficile-infection-a-clinical-update
#27
REVIEW
Lindsay M Clarke, Jessica R Allegretti
BACKGROUND: Clostridioides difficile is the most common cause of healthcare-associated infection, and severe cases can result in significant complications. While anti-microbial therapy is central to infection management, adjunctive therapies may be utilised as preventative strategies. AIM: This article aims to review updates in the epidemiology, diagnosis, and management, including treatment and prevention, of C. difficile infections. METHODS: A narrative review was performed to evaluate the current literature between 1986 and 2023...
March 27, 2024: Alimentary Pharmacology & Therapeutics
https://read.qxmd.com/read/38534211/diagnosis-and-management-of-catastrophic-antiphospholipid-syndrome-and-the-potential-impact-of-the-2023-acr-eular-antiphospholipid-syndrome-classification-criteria
#28
REVIEW
Lucas Jacobs, Nader Wauters, Yahya Lablad, Johann Morelle, Maxime Taghavi
Catastrophic antiphospholipid syndrome (CAPS) is a rare and life-threatening condition characterized by the persistence of antiphospholipid antibodies and occurrence of multiple vascular occlusive events. CAPS currently remains a diagnostic challenge and requires urgent treatment. The diagnosis of CAPS is made difficult by classification criteria used as diagnostic criteria in clinical practice, knowledge derived from retrospective data and case reports, confounding clinical and biological features, and its rapid onset and mortality...
March 12, 2024: Antibodies
https://read.qxmd.com/read/38534149/targeting-intracellular-nontuberculous-mycobacteria-and-m-tuberculosis-with-a-bactericidal-enzymatic-cocktail
#29
JOURNAL ARTICLE
Helen P Bartlett, Clinton C Dawson, Cody M Glickman, David W Osborn, Christopher R Evans, Benjamin J Garcia, Lauren C Frost, Jason E Cummings, Nicholas Whittel, Richard A Slayden, Jason W Holder
To address intracellular mycobacterial infections, we developed a cocktail of four enzymes that catalytically attack three layers of the mycobacterial envelope. This cocktail is delivered to macrophages, through a targeted liposome presented here as ENTX_001. Endolytix Cocktail 1 (EC1) leverages mycobacteriophage lysin enzymes LysA and LysB, while also including α-amylase and isoamylase for degradation of the mycobacterial envelope from outside of the cell. The LysA family of proteins from mycobacteriophages has been shown to cleave the peptidoglycan layer, whereas LysB is an esterase that hydrolyzes the linkage between arabinogalactan and mycolic acids of the mycomembrane...
March 27, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38533339/endophytic-aspergillus-hiratsukae-mediated-biosynthesis-of-silver-nanoparticles-and-their-antimicrobial-and-photocatalytic-activities
#30
JOURNAL ARTICLE
Ebrahim Saied, Mostafa A Abdel-Maksoud, Akram A Alfuraydi, Bushra Hafeez Kiani, Mohamed Bassyouni, Osama A Al-Qabandi, Fathia H E Bougafa, Mona Shaban E M Badawy, Amr H Hashem
In the current study, endophytic Aspergillus hiratsukae was used for the biosynthesis of silver nanoparticles (Ag-NPs) for the first time. The characterizations were performed using X ray diffraction (XRD), Transmission electron microscopy (TEM), Scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX), Dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FT-IR), and UV-Vis spectroscopy. The obtained results demonstrated the successful formation of crystalline, spherical Ag-NPs with particle diameters ranging from 16 to 31 nm...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38533241/capping-agents-enable-well-dispersed-and-colloidally-stable-metallic-magnesium-nanoparticles
#31
JOURNAL ARTICLE
Thomas M R Wayman, Vladimir Lomonosov, Emilie Ringe
Mg nanoparticles are an emerging plasmonic material due to Mg's abundance and ability to sustain size- and shape-dependent localized surface plasmon resonances across a broad range of wavelengths from the ultraviolet to the near infrared. However, Mg nanoparticles are colloidally unstable due to their tendency to aggregate and sediment. Nanoparticle aggregation can be inhibited by the addition of capping agents that impart surface charges or steric repulsion. Here, we report that the common capping agents poly(vinyl) pyrrolidone (PVP), polyethylene glycol (PEG), cetyltrimethylammonium bromide (CTAB), and sodium dodecyl sulfate (SDS) interact differently and have varied effects on the aggregation and colloidal stability of Mg nanoparticles...
March 21, 2024: Journal of Physical Chemistry. C, Nanomaterials and Interfaces
https://read.qxmd.com/read/38533036/clinical-effects-and-mechanisms-of-a-chinese-patent-medicine-tongxinluo-capsule-as-an-adjuvant-treatment-in-coronary-heart-disease
#32
REVIEW
Jing Wang, Tian Li Li, Pei Fen Chang, Yu Qian Gao, Jia Sai Fan, Chen Hao Zhang, Hai Yan Zhu
Coronary heart disease (CHD) is the leading cause of death globally, posing a serious threat to human health. However, the current treatment approaches available for CHD fall short of the ideal results. Tongxinluo (TXL) is a traditional Chinese medicine (TCM) that has been employed in the clinical treatment of cardiovascular and cerebrovascular diseases (such as angina pectoris, stroke, etc.) in China for many years and holds great potential as a prospective treatment. TXL either as a standalone treatment or in combination with interventions recommended in CHD guidelines has been shown to be effective and well tolerated in clinical trials for CHD...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38532896/investigating-the-impact-of-elevated-urinary-trace-elements-on-non-alcoholic-fatty-liver-disease-using-vibration-controlled-transient-elastography
#33
JOURNAL ARTICLE
Chenxiao Wang, Xin Shang, Yu Fu, Panpan Guo, Ping Wang, Shuxun Yan
INTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) is a global public health concern. However, limited data are available on urinary trace elements and NAFLD caused by various exposure factors. This study aimed to investigate the relationship between the presence of 16 trace elements in urine and NAFLD using data from the National Health and Nutrition Examination Survey (NHANES). METHODS: By utilizing the NHANES data from 2017 to 2018, 1613 participants who fulfilled the research criteria were identified from the initial pool of 2979 participants with available urine trace element detection data...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38532882/bioglass-ceria-nanoparticle-hybrids-for-the-treatment-of-seroma-a-comparative-long-term-study-in-rats
#34
JOURNAL ARTICLE
Michael-Alexander Pais, Athanasios Papanikolaou, Isabel Arenas Hoyos, Robert Nißler, Simone De Brot, Alexander Gogos, Robert Rieben, Mihai A Constantinescu, Martin T Matter, Inge K Herrmann, Ioana Lese
Background: Seroma formation is a common postoperative complication. Fibrin-based glues are typically employed in an attempt to seal the cavity. Recently, the first nanoparticle (NP)-based treatment approaches have emerged. Nanoparticle dispersions can be used as tissue glues, capitalizing on a phenomenon known as 'nanobridging'. In this process, macromolecules such as proteins physically adsorb onto the NP surface, leading to macroscopic adhesion. Although significant early seroma reduction has been shown, little is known about long-term efficacy of NPs...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38532846/predicting-endothelium-dependent-diastolic-function-fmd-and-its-correlation-with-the-degree-of-coronary-artery-disease-cad-and-plaque-vulnerability-for-cardiovascular-events
#35
JOURNAL ARTICLE
Guangming Zhang, Jing Yang, Hanghang Xing, Hongning Yin, Guoqing Gu
OBJECTIVE: This study aims to investigate the correlation between vascular endothelium-dependent diastolic function (FMD) and the degree of coronary artery disease (CAD), plaque vulnerability, and its predictive value for cardiovascular events. METHODS: Initially, patients (n=100) who were admitted from January 2020 to January 2021 and intended to undergo percutaneous coronary intervention (PCI) were selected. Further, FMD in all patients was determined before the procedure and divided into a high-FMD group (≥4...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38532806/ph-responsive-interface-conversion-efficient-oral-drug-delivery-platform-for-alleviating-inflammatory-bowel-disease
#36
JOURNAL ARTICLE
Yingying Zhao, Changqing Xu, Qing Liu, Xiaofei Lei, Li Deng, Fengyan Wang, Jing Yang
A key challenge for the effective treatment of intestinal diseases, including inflammatory bowel disease (IBD), is to develop an oral drug delivery system that can resist gastric acid erosion and efficiently release drugs after rapid entry into the intestine. In the present work, we developed oral composite nanoparticles (MSZ@PRHS) consisting of a rough mesoporous silica (RHS) loaded with Mesalazine (MSZ) and a CAP polymer membrane for targeted relief of inflammation in colitis. At the pH values of the simulated stomach and small intestine, the release rate of MSZ from MSZ@PRHS was low, while at the pH values of the simulated colon, the release rate of MSZ was high...
2024: Frontiers in Chemistry
https://read.qxmd.com/read/38532714/multimodal-imaging-of-a-case-of-retinal-cavernous-hemangioma
#37
JOURNAL ARTICLE
Fanyu Guan, Wenting Luo, Guimei Xia
PURPOSE: Herein, we reported a case of retinal cavernous hemangioma (RCH) and its multimodal imaging. CASE PRESENTATION: Many grape-like lesions were incidentally found along the distal portion of the vascular arcade in a 23-year-old man's superonasal quadrant of the retina. The best-corrected visual acuity was 20/20 in both eyes. The fluorescein angiography showed saccular lesions that slowly filled with hypofluorescence in the early stage and clusters of aneurysms with hyperfluorescence and a special "fluorescein cap" appearance in the late stage...
March 27, 2024: European Journal of Ophthalmology
https://read.qxmd.com/read/38532367/long-term-real-life-outcomes-of-the-clareon%C3%A2-hydrophobic-intraocular-lens-the-clarte-study-in-191-eyes-3-years-real-life-outcomes-of-the-clareon%C3%A2-intraocular-lens
#38
JOURNAL ARTICLE
Bouvarel Hugo, Agard Emilie, Billant Jérémy, Levron Antoine, Chudzinski Roman, Plas Hélène, Bernier Raphaël, Sejournet Lucas, Chaperon Mayeul, Dot Corinne
BACKGROUND: To describe and analyze the real-life refractive, functional and safety outcomes of the Clareon® intraocular lens (IOL) after 3 years. METHODS: Data was collected retrospectively for observational purposes between July 2017 and December 2019 in the ophthalmology department of Desgenettes military hospital in Lyon, France. Eyes that underwent cataract surgery with Claeron® implantation were consecutively included. Patients with a systemic or ocular condition that could affect the visual outcome were excluded...
March 26, 2024: BMC Ophthalmology
https://read.qxmd.com/read/38532200/investigation-of-two-new-grafting-techniques-for-dorsal-augmentation-rhinoplasty-an-experimental-study-with-new-zealand-white-rabbits
#39
JOURNAL ARTICLE
Mehmet Ozdemır, Mehmet Fatih Akkoç, Selcuk Tunık
INTRODUCTION: Cartilage is an important source in supporting the structure of the nose for dorsal augmentation rhinoplasty. However, it is known that its viability is not always on the ideal level. Various wrapping materials are used to increase the strength of cartilage. Donor site morbidity, which develops following the harvesting of both cartilage and fascia as one such cover material, has attracted interest in recent years. OBJECTIVE: In this study, we aimed to investigate the potential of dermis and tendon autografts as alternatives to fascia and cartilage...
March 26, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38532076/follicular-dendritic-cell-sarcoma-arising-from-the-lymph-node-of-the-pancreatic-head-a-case-report-with-literature-review
#40
JOURNAL ARTICLE
Takahiro Yamada, Keinosuke Ishido, Norihisa Kimura, Taiichi Wakiya, Hayato Nagase, Shintaro Goto, Tadashi Yoshizawa, Hiroshi Kijima, Seiichi Kato, Kenichi Hakamada
A 72-year-old man was referred to our hospital for the examination of a pancreatic head mass. Abdominal computed tomography revealed a contrasted 8-cm-diameter tumor extending from the dorsal pancreatic head to the porta hepatis. The preoperative diagnosis was challenging due to the absence of specific imaging findings and the inability to perform a biopsy. Positron emission tomography/computed tomography and diffusion-weighted imaging suggested a malignant tumor originating from the organs surrounding the pancreatic head...
March 26, 2024: Clinical Journal of Gastroenterology
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