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https://www.readbyqxmd.com/read/29475034/stable-state-mr-proadrenomedullin-is-associated-with-severe-exacerbations-in-copd
#1
Emanuel Citgez, Maaike Zuur-Telgen, Job van der Palen, Paul van der Valk, Daiana Stolz, Marjolein Brusse-Keizer
BACKGROUND: Elevated levels of Midrange-proadrenomedullin (MR-proADM) is associated with worse outcome in different diseases among which COPD. The association of stable state MR-proADM with severe exacerbations of COPD requiring hospitalisation (severe AECOPD), or with community acquired pneumonia (CAP) in COPD patients has not been studied yet. AIMS AND OBJECTIVES: The aim of this study was to evaluate the association of stable state MR-proADM with severe AECOPD and CAP in COPD patients...
February 20, 2018: Chest
https://www.readbyqxmd.com/read/29474989/proportion-of-adult-community-acquired-pneumonia-cases-attributable-to-streptococcus-pneumoniae-among-hajj-pilgrims-in-2016
#2
Ali AlBarrak, Badriah Alotaibi, Yara Yassin, Abdulaziz Mushi, Fuad Maashi, Yassein Seedahmed, Mohamed Alshaer, Abdulaziz Altaweel, Husameddin Elshiekh, Abdulhafiz Turkistani, Tanaz Petigara, John Grabenstein, Saber Yezli
BACKGROUND: The Hajj mass gathering is a risk for pneumococcal disease. We evaluated the proportion of adult community-acquired pneumonia (CAP) cases attributable to Streptococcus pneumoniae among Hajj pilgrims in 2016. To add sensitivity to etiologic attribution, we used a urine-antigen test, in addition to culture-based methods METHODS: Adults hospitalized with x-ray confirmed CAP were prospectively enrolled from all general hospitals designated to treat Hajj pilgrims in the holy cities of Mecca and Medina...
February 20, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29474649/characterization-of-resistance-to-cephus-cinctus-hymenoptera-cephidae-in-barley-germplasm
#3
Andrea C Varella, Luther E Talbert, Buddhi B Achhami, Nancy K Blake, Megan L Hofland, Jamie D Sherman, Peggy F Lamb, Gadi V P Reddy, David K Weaver
Most barley cultivars have some degree of resistance to the wheat stem sawfly (WSS), Cephus cinctus Norton (Hymenoptera: Cephidae). Damage caused by WSS is currently observed in fields of barley grown in the Northern Great Plains, but the impact of WSS damage among cultivars due to genetic differences within the barley germplasm is not known. Specifically, little is known about the mechanisms underlying WSS resistance in barley. We characterized WSS resistance in a subset of the spring barley CAP (Coordinated Agricultural Project) germplasm panel containing 193 current and historically important breeding lines from six North American breeding programs...
February 21, 2018: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29474476/rage-dependent-potentiation-of-trpv1-currents-in-sensory-neurons-exposed-to-high-glucose
#4
Doris Lam, Zeinab Momeni, Michael Theaker, Santosh Jagadeeshan, Yasuhiko Yamamoto, Juan P Ianowski, Verónica A Campanucci
Diabetes mellitus is associated with sensory abnormalities, including exacerbated responses to painful (hyperalgesia) or non-painful (allodynia) stimuli. These abnormalities are symptoms of diabetic peripheral neuropathy (DPN), which is the most common complication that affects approximately 50% of diabetic patients. Yet, the underlying mechanisms linking hyperglycemia and symptoms of DPN remain poorly understood. The transient receptor potential vanilloid 1 (TRPV1) channel plays a central role in such sensory abnormalities and shows elevated expression levels in animal models of diabetes...
2018: PloS One
https://www.readbyqxmd.com/read/29473945/home-based-primary-care-beyond-extension-of-the-independence-at-home-demonstration
#5
James Rotenberg, Bruce Kinosian, Peter Boling, George Taler
The Independence at Home (IAH) Demonstration Year 2 results confirmed that the first-year savings were 10 times as great as those of the pioneer accountable care organizations during their initial 2 years. We update projected savings from nationwide conversion of the IAH demonstration, incorporating Year 2 results and improving attribution of IAH-qualified (IAH-Q) Medicare beneficiaries to home-based primary care (HBPC) practices. Applying IAH qualifying criteria to beneficiaries in the Medicare 5% claims file, the effect of expanding HBPC to the 2...
February 23, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29473911/methionine-capped-gold-nanoclusters-as-a-fluorescence-enhanced-probe-for-cadmium-ii-sensing
#6
Yan Peng, Maomao Wang, Xiaoxia Wu, Fu Wang, Lang Liu
Gold nanoclusters (Au NCs) have been considered as novel heavy metal ions sensors due to their ultrafine size, photo-stability and excellent fluorescent properties. In this study, a green and facile method was developed for the preparation of fluorescent water-soluble gold nanoclusters with methionine as a stabilizer. The nanoclusters emit orange fluorescence with excitation/emission peaks at 420/565 nm and a quantum yield of about 1.46%. The fluorescence of the Au NCs is selectively and sensitively enhanced by addition of Cd(II) ions attributed to the Cd(II) ion-induced aggregation of nanoclusters...
February 23, 2018: Sensors
https://www.readbyqxmd.com/read/29473408/adaptation-of-operational-parameters-of-cold-atmospheric-plasma-for-in-vitro-treatment-of-cancer-cells
#7
Eda Gjika, Sonali Pal-Ghosh, Anna Tang, Megan Kirschner, Gauri Tadvalkar, Jerome Canady, Mary Ann Stepp, Michael Keidar
Cold atmospheric plasma (CAP), an ionized gas operated at near ambient temperature has been introduced as a new therapeutic opportunity for treating cancers. The effectiveness of the therapy has been linked to CAP generated reactive oxygen and nitrogen species such as hydrogen peroxide and nitrite. In this study, we monitor in real time cancer cell response to CAP over the course of 48 hours. The results demonstrate a correlation between cell viability, exposure time (30, 60, 90, 180-s) and discharge voltage (3...
February 23, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29472761/more-new-deep-reef-basslets-teleostei-grammatidae-lipogramma-with-updates-on-the-eco-evolutionary-relationships-within-the-genus
#8
Carole C Baldwin, Luke Tornabene, D Ross Robertson, Ai Nonaka, R Grant Gilmore
Two new Lipogramma basslets are described, L. barrettorum and L. schrieri , captured during submersible diving to 300 m depth off Curaçao, southern Caribbean. Superficially resembling L. robinsi in having 11-12 bars of pigment on the trunk, L. barrettorum is distinct from L. robinsi in having a stripe of blue-white pigment along the dorsal midline of the head (vs. a cap of yellow pigment), in patterns of pigment on the median fins, and in having 8-10 gill rakers on the lower limb of the first arch (vs. 11-12)...
2018: ZooKeys
https://www.readbyqxmd.com/read/29472415/cluster-randomized-trial-of-devices-to-prevent-catheter-related-bloodstream-infection
#9
Steven M Brunelli, David B Van Wyck, Levi Njord, Robert J Ziebol, Laurie E Lynch, Douglas P Killion
Central venous catheters (CVCs) contribute disproportionately to bloodstream infection (BSI) and, by extension, to infection-related hospitalization, mortality, and health care costs in patients undergoing dialysis. Recent product advancements may reduce BSIs, but a sufficiently powered comparative-effectiveness study is needed to facilitate evidence-based patient care decisions. In a 13-month, prospective, cluster-randomized, open-label trial, we compared BSI rates in facilities using ClearGuard HD antimicrobial barrier caps (ClearGuard group) with those in facilities using Tego hemodialysis connectors plus Curos disinfecting caps (Tego+Curos group)...
February 22, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29471997/always-on-my-mind
#10
Stephen Balter
This article is focused on occupational radiogenic brain tumors and some radioprotective techniques used to manage this risk. Published case reports have stimulated concern among operators. The anatomical pattern of tumor locations is not consistent with measured radiation dose distributions at operators' heads. In addition, the lack of statistically positive findings in these reports, and a recently published survey on radiologist's mortality both indicate that the current level of fluoroscopists' radiation safety practices is likely to be adequate...
March 2018: Techniques in Vascular and Interventional Radiology
https://www.readbyqxmd.com/read/29471725/dignity-from-the-nurses-and-older-patients-perspective-a-qualitative-literature-review
#11
Šárka Šaňáková, Juraj Čáp
INTRODUCTION: Dignity is one of the most important values sensitively perceived by patients in nursing care. Older patients have been identified as having a high risk of losing their dignity in institutional care. To promote optimum nursing care, a deeper insight into the problem of older patients' dignity is needed. AIM: The aim was to identify, analyse and synthesise the qualitative evidence of dignity views and factors affecting it from the nurses' and older patients' perspective in the context of nursing care and to compare synthesised finding from the both perspective...
January 1, 2018: Nursing Ethics
https://www.readbyqxmd.com/read/29471506/a-translational-silencing-function-of-mcpip1-regnase-1-specified-by-the-target-site-context
#12
Gesine Behrens, Reinhard Winzen, Nina Rehage, Anneke Dörrie, Monika Barsch, Anne Hoffmann, Jörg Hackermüller, Christopher Tiedje, Vigo Heissmeyer, Helmut Holtmann
The expression of proteins during inflammatory and immune reactions is coordinated by post-transcriptional mechanisms. A particularly strong suppression of protein expression is exerted by a conserved translational silencing element (TSE) identified in the 3' UTR of NFKBIZ mRNA, which is among the targets of the RNA-binding proteins Roquin-1/2 and MCPIP1/Regnase-1. We present evidence that in the context of the TSE MCPIP1, so far known for its endonuclease activity toward mRNAs specified by distinct stem-loop (SL) structures, also suppresses translation...
February 19, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29471488/morphological-responses-of-plant-roots-to-mechanical-stress
#13
Izabela Potocka, Joanna Szymanowska-Pulka
Background: Roots are continuously exposed to mechanical pressure and this often results in their morphological modification. Most obvious are changes in the overall form of the root system as well as in the shapes of particular roots. These changes are often accompanied by modifications of the cell pattern and cell morphology. Scope: This review focuses on the morphological responses of roots to mechanical stress. Results of early and recent experiments in which roots have been exposed to mechanical pressure are assembled, analysed and discussed...
February 17, 2018: Annals of Botany
https://www.readbyqxmd.com/read/29470945/porcine-circovirus-2-in-the-north-eastern-region-of-india-disease-prevalence-and-genetic-variation-among-the-isolates-from-areas-of-intensive-pig-rearing
#14
Priyanka Mukherjee, Amarjit Karam, Luit Barkalita, Prabodh Borah, Amit Kr Chakraborty, Samir Das, Kekungo Puro, Rajkumari Sanjukta, Sandeep Ghatak, Ingudam Shakuntala, Ram Gopal Laha, Arnab Sen, Indu Sharma
Porcine Circovirus type-2 (PCV-2) is considered as a major threat to the piggery sector in India. To ascertain the epidemiological status and infection level of PCV2, a pilot study was undertaken to find out the prevalence of PCV2 in swine population by ELISA and PCR in the interior and border areas of Meghalaya which includes the area where accessibility and medical aid is a rare phenomenon. A total of 249 serum samples were collected from October 2014 to February 2016 from three divisions of Meghalaya: Khasi, Jaintia and Garo Hills Divisions...
February 19, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29470537/microsomal-prostaglandin-e-synthase-1-gene-deletion-impairs-neuro-immune-circuitry-of-the-cholinergic-anti-inflammatory-pathway-in-endotoxaemic-mouse-spleen
#15
Priya Revathikumar, Johanna Estelius, Utsa Karmakar, Erwan Le Maître, Marina Korotkova, Per-Johan Jakobsson, Jon Lampa
The cholinergic anti-inflammatory pathway (CAP) is an innate neural reflex where parasympathetic and sympathetic nerves work jointly to control inflammation. Activation of CAP by vagus nerve stimulation (VNS) has paved way for novel therapeutic strategies in treating inflammatory diseases. Recently, we discovered that VNS mediated splenic acetylcholine (ACh) release and subsequent immunosuppression in response to LPS associated inflammation is impaired in mice lacking microsomal prostaglandin E synthase-1 (mPGES-1) expression, a key enzyme responsible for prostaglandin E2 synthesis...
2018: PloS One
https://www.readbyqxmd.com/read/29469217/effect-of-treatment-with-direct-acting-antivirals-on-body-mass-index-and-hepatic-steatosis-in-chronic-hepatitis-c
#16
Hend Ibrahim Shousha, Rasha Ahmed Abdelaziz, Sherief Musa Azab, Marwa Khairy, Shahira Ahmed Afifi, Mai Ismael Mehrez, Mohamed Ali Eshra, Ayman Yosry Abdelrahim
BACKGROUND: Direct Acting Agents (DAAs) have high cure rate but still lack the knowledge of their effect on hepatic steatosis in chronic hepatitis C (CHC). Controlled Attenuation Parameter (CAP), evaluated with transient elastography, could help in assessment of steatosis grades. We aim to evaluate the effect of DAAs on BMI and steatosis in CHC using CAP. PATIENTS AND METHODS: This cohort study included 155 CHC Egyptian patients divided into three groups according to the DAAs regimens...
February 22, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29469187/the-prediction-of-cyclic-proximal-humerus-fracture-fixation-failure-by-various-bone-density-measures
#17
Peter Varga, Leonard Grünwald, Markus Windolf
Fixation of osteoporotic proximal humerus fractures has remained challenging, but may be improved by careful pre-operative planning. The aim of this study was to investigate how well the failure of locking plate fixation of osteoporotic proximal humerus fractures can be predicted by bone density measures assessed with currently available clinical imaging (realistic case) and a higher resolution and quality modality (theoretical best-case). Various density measures were correlated to experimentally assessed number of cycles to construct failure of plated unstable low-density proximal humerus fractures (N = 18)...
February 22, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29469058/straightforward-measurement-of-anisotropic-thermal-properties-of-a-bi-2-se-3-single-crystal
#18
D Fournier, M Marangolo, M Eddrief, N N Kolesnikov, C Fretigny
We demonstrate here a simple measurement protocol which allows the thermal properties of anisotropic crystalline materials to be determined. This protocol is validated by the measurement of Bi2 Se3 , a layered material consisting of covalently bonded sheets with weak van der Waals bonds between each layer, which has highly anisotropic thermal properties. Thermoreflectance microscopy measurements were carried out on a single-crystal Bi2 Se3 sample, firstly on the bare sample and then after capping with a 100 nm thick gold layer...
February 22, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29468828/liquid-exfoliation-of-colloidal-rhenium-disulfide-nanosheets-as-a-multifunctional-theranostic-agent-for-in-vivo-photoacoustic-ct-imaging-and-photothermal-therapy
#19
Zhao-Hua Miao, Lan-Xiang Lv, Kai Li, Pei-Ying Liu, Zhenglin Li, Huanjie Yang, Qingliang Zhao, Manli Chang, Liang Zhen, Cheng-Yan Xu
Near-infrared light-mediated theranostic agents with superior tissue penetration and minimal invasion have captivated researchers in cancer research in the past decade. Herein, a probe sonication-assisted liquid exfoliation approach for scalable and continual synthesis of colloidal rhenium disulfide nanosheets, which is further explored as theranostic agents for cancer diagnosis and therapy, is reported. Due to high-Z element of Re (Z = 75) and significant photoacoustic effect, the obtained PVP-capped ReS2 nanosheets are evaluated as bimodality contrast agents for computed tomography and photoacoustic imaging...
February 22, 2018: Small
https://www.readbyqxmd.com/read/29468722/podoplanin-positive-myofibroblasts-a-pathologic-hallmark-of-pleuroparenchymal-fibroelastosis
#20
Yasunori Enomoto, Sayomi Matsushima, Shiori Meguro, Hideya Kawasaki, Isao Kosugi, Tomoyuki Fujisawa, Noriyuki Enomoto, Naoki Inui, Yutaro Nakamura, Takafumi Suda, Toshihide Iwashita
Pathologic differential diagnoses of pleuroparenchymal fibroelastosis (PPFE) include usual interstitial pneumonia (UIP) and pulmonary apical cap (PAC); however, there are no specific immunostaining makers to distinguish between these diseases. We performed immunohistochemistry using several pleural mesothelial cell-related markers, including cytokeratin-5/6, CAM5.2, WT-1, calretinin, desmin and podoplanin, for PPFE (n = 4), UIP (n = 10) and PAC (n = 3) lung sections. Among the examined markers, in PPFE and PAC lungs, podoplanin commonly showed positivity for spindle cells both in thickened pleura and subpleural fibroelastosis lesions; these cells were also stained with α-smooth muscle actin, a marker of myofibroblasts...
February 22, 2018: Histopathology
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