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https://www.readbyqxmd.com/read/29666834/androgen-action-in-prostate-function-and-disease
#1
REVIEW
Partha P Banerjee, Subhadra Banerjee, Terry R Brown, Barry R Zirkin
Benign prostatic hyperplasia (BPH) is an enlargement of the prostate gland that is frequently found in aging men. Androgens are essential for the development and differentiated function of the prostate, as well as for proliferation and survival of prostatic cells. In man, dog and rodent, there are age-related decreases in serum testosterone. Despite the lower serum testosterone levels, benign prostatic hyperplasia increases with age in men and dogs, while age-dependent prostatic hyperplasia develops in the dorsal and lateral lobes of the rat prostate...
2018: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29665823/exposure-to-concentrated-ambient-pm-2-5-alters-the-composition-of-gut-microbiota-in-a-murine-model
#2
Wanjun Wang, Ji Zhou, Minjie Chen, Xingke Huang, Xiaoyun Xie, Weihua Li, Qi Cao, Haidong Kan, Yanyi Xu, Zhekang Ying
BACKGROUND: Exposure to ambient fine particulate matter (PM2.5 ) correlates with abnormal glucose homeostasis, but the underlying biological mechanism has not been fully understood. The gut microbiota is an emerging crucial player in the homeostatic regulation of glucose metabolism. Few studies have investigated its role in the PM2.5 exposure-induced abnormalities in glucose homeostasis. METHODS: C57Bl/6J mice were exposed to filtered air (FA) or concentrated ambient PM2...
April 17, 2018: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29665554/inhibition-by-non-steroidal-anti-inflammatory-drugs-of-compound-action-potentials-in-frog-sciatic-nerve-fibers
#3
Rika Suzuki, Tsugumi Fujita, Kotaro Mizuta, Eiichi Kumamoto
AIMS: Although antinociception produced by non-steroidal anti-inflammatory drugs (NSAIDs) is partly attributed to nerve conduction inhibition, this has not been thoroughly examined yet. The aim of the present study was to reveal quantitatively how various types of NSAIDs affect compound action potentials (CAPs), a measure of nerve conduction. MAIN METHODS: CAPs were recorded from the frog sciatic nerve by using the air-gap method. KEY FINDINGS: Soaking the sciatic nerve with acetic acid-based NSAIDs (diclofenac and aceclofenac) reduced the peak amplitude of CAP in a concentration-dependent manner; their IC50 values were 0...
April 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29665161/poverty-as-an-independent-risk-factor-for-in-hospital-mortality-in-community-acquired-pneumonia-a-study-in-a-developing-country-population
#4
Hassan Jahanihashemi, Mona Babaie, Soroush Bijani, Maryam Bazzazan, Behzad Bijani
BACKGROUND: Community-acquired pneumonia (CAP) is one of the most severe lower respiratory tract infections with a high in-hospital mortality. The aim of this study was to investigate the socioeconomic and medical risk factors affecting the prognosis of acute pneumonia. The results of this study can mention the value of socioeconomic backgrounds like poverty and illiteracy in clinical practice, even in a well-known biological phenomenon (eg acute pneumonia). METHODS: In this cross-sectional study, all admitted patients to a tertiary teaching hospital with a diagnosis of community acquired pneumonia in a 12-month period were enrolled...
April 17, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29665036/stable-mirna-overexpression-in-human-cap-cells-engineering-alternative-production-systems-for-advanced-manufacturing-of-biologics-using-mir-136-and-mir-3074
#5
Benjamin L Weis, Nadine Guth, Simon Fischer, Silke Wissing, Simon Fradin, Karl-Heinz Holzmann, René Handrick, Kerstin Otte
Chinese hamster ovary (CHO) cells still represent the major production host for therapeutic proteins. However, multiple limitations have been acknowledged leading to the search for alternative expression systems. CEVEC's amniocyte production (CAP) cells are human production cells demonstrated to enable efficient overexpression of recombinant proteins with human glycosylation pattern. However, CAP cells have not yet undergone any engineering approaches to optimize process parameters for a cheaper and more sustainable production of biopharmaceuticals...
April 17, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29664920/linear-self-assembly-and-grafting-of-gold-nanorods-into-arrayed-micrometer-long-nanowires-on-a-silicon-wafer-via-a-combined-top-down-bottom-up-approach
#6
Elena Lestini, Codrin Andrei, Dominic Zerulla
Macroscopically long wire-like arrangements of gold nanoparticles were obtained by controlled evaporation and partial coalescence of an aqueous colloidal solution of capped CTAB-Au nanorods onto a functionalised 3-mercaptopropyl trimethoxysilane (MPTMS) silicon substrate, using a removable, silicon wafer with a hydrophobic surface that serves as a "handrail" for the initial nanorods' linear self-assembly. The wire-like structures display a quasi-continuous pattern by thermal annealing of the gold nanorods when the solvent (i...
2018: PloS One
https://www.readbyqxmd.com/read/29664331/handheld-raman-spectrometer-instrumentation-for-quantitative-tuberculosis-biomarker-detection-a-performance-assessment-for-point-of-need-infectious-disease-diagnostics
#7
Nicholas A Owens, Lars B Laurentius, Marc D Porter, Qun Li, Sean Wang, Delphi Chatterjee
Techniques for the detection of disease biomarkers are key components in the protection of human health. While work over the last few decades has redefined the low-level measurement of disease biomarkers, the translation of these capabilities from the formal clinical setting to point-of-need (PON) usage has been much more limited. This paper presents the results of experiments designed to examine the potential utility of a handheld Raman spectrometer as a PON electronic reader for a sandwich immunoassay based on surface-enhanced Raman scattering (SERS)...
January 1, 2018: Applied Spectroscopy
https://www.readbyqxmd.com/read/29664089/radioluminescence-studies-of-colloidal-oleate-capped-%C3%AE-na-gd-lu-f-4-ln-3-nanoparticles-ln-ce-eu-tb
#8
Daniel R Cooper, John A Capobianco, Jan Seuntjens
We report on the synthesis, characterization, and radioluminescence quantification of several new varieties of nanoparticles with the general composition β-NaLnF4, incorporating known luminescent activator/sensitizer pairs. Using Monte Carlo modeling to complement luminescence measurements, we have calculated the radioluminescence yields and intrinsic conversion efficiencies of colloidally-dispersed nanoparticles by comparison to an organic liquid scintillator. While five of the compositions had low to modest radioluminescence yields relative to bulk materials, colloidal β-Na(Lu0...
April 17, 2018: Nanoscale
https://www.readbyqxmd.com/read/29663060/a-novel-fluorescent-biosensor-for-adrenaline-detection-and-tyrosinase-inhibitor-screening
#9
Ziping Liu, Shasha Liu
In this work, a novel simple fluorescent biosensor for the highly sensitive and selective detection of adrenaline was established. Firstly, water-soluble CuInS2 quantum dots (QDs) capped by L-Cys were synthesized via a hydrothermal synthesis method. Then, the positively charged adrenaline was assembled on the surface of CuInS2 QDs due to the electrostatic interactions and hydrogen bonding, which led to the formation of adrenaline-CuInS2 QD (Adr-CuInS2 QD) electrostatic complexes. Tyrosinase (TYR) can catalyze adrenaline to generate H2 O2 , and additionally oxidize the adrenaline to adrenaline quinone...
April 17, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29662981/examination-of-inequivalent-wetting-on-the-crystal-habit-surfaces-of-rs-ibuprofen-using-grid-based-molecular-modelling
#10
I Rosbottom, J H Pickering, B Etbon, R B Hammond, K J Roberts
Synthonic engineering tools, including grid-based searching molecular modelling, are applied to investigate the wetting interactions of the solute and four crystallisation solvents (ethanol, ethyl acetate, acetonitrile and toluene) with the {100}, {001} and {011} forms of RS-ibuprofen. The grid-based methods, in particular the construction of a crystal slab parallel to a given plane in a coordinate system with one axis perpendicular to the surface, are defined in detail. The interaction strengths and nature (dispersive, hydrogen bonding (H-bonding) or coulombic forces) are related to the crystal growth rates and morphologies...
April 17, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29662908/portable-brain-computer-interface-for-the-intensive-care-unit-patient-communication-using-subject-dependent-ssvep-identification
#11
Omid Dehzangi, Muhamed Farooq
A major predicament for Intensive Care Unit (ICU) patients is inconsistent and ineffective communication means. Patients rated most communication sessions as difficult and unsuccessful. This, in turn, can cause distress, unrecognized pain, anxiety, and fear. As such, we designed a portable BCI system for ICU communications (BCI4ICU) optimized to operate effectively in an ICU environment. The system utilizes a wearable EEG cap coupled with an Android app designed on a mobile device that serves as visual stimuli and data processing module...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29661307/effect-of-ph-and-precursor-salts-on-in-situ-formation-of-calcium-phosphate-nanoparticles-in-methylcellulose-hydrogel
#12
Min Hee Kim, Hanna Park, Won Ho Park
Thermo-reversible hydrogels have been widely studied in biomedical research fields, because of their potential performance in drug delivery and tissue engineering. In this study, a novel thermo-sensitive methylcellulose (MC) hydrogel based on calcium phosphate nanoparticles (CaP NPs) was prepared by in situ formation process in which precursor salts induced a salt-out effect in the MC solution. Based on the Hofmeister series, CaCl2 , Na2 HPO4 , and NaH2 PO4 precursor salts with a good salt-out effect were used as the precursor salts for CaP NPs...
July 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29661135/the-relative-burden-of-community-acquired-pneumonia-hospitalizations-in-older-adults-a-retrospective-observational-study-in-the-united-states
#13
Joshua D Brown, James Harnett, Richard Chambers, Reiko Sato
BACKGROUND: The risk of community-acquired pneumonia (CAP) increases with age and significantly impacts morbidity and mortality in the elderly population. The burden of illness and cost of preventing CAP has not been compared to other serious diseases. METHODS: This retrospective analysis used claims data from 2014 to 2015 and compared hospitalizations for CAP, myocardial infarction (MI), stroke, and osteoporotic fractures (OF) in adults aged ≥65 years enrolled in a Medicare Advantage insurance plan...
April 16, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29660488/changes-in-the-radicular-pulp-dentine-complex-in-healthy-intact-teeth-and-in-response-to-deep-caries-or-restorations-a-histological-and-histobacteriological-study
#14
Domenico Ricucci, Simona Loghin, Li-Na Niu, Franklin R Tay
INTRODUCTION: The present study reported the histological events that occurred in the radicular pulp of human mature teeth in the presence of medium/deep untreated caries lesions, and those teeth with restorations or direct pulp capping, with particular emphasis on the morphology of the canal wall dentine and the odontoblast layer. METHODS: Sixty-two teeth with medium/deep caries lesions, extensive restorations or after application of a direct pulp capping procedure were obtained from 57 subjects...
April 13, 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29660428/the-kinetics-of-anti-drug-antibodies-drug-levels-and-clinical-outcomes-in-infliximab-exposed-patients-with-immuno-mediated-disorders
#15
Nencini Francesca, Vultaggio Alessandra, Pratesi Sara, Cammelli Daniele, Milla Monica, Fiori Ginevra, Bagnoli Siro, Prignano Francesca, Romagnani Sergio, Maggi Enrico, Matucci Andrea
BACKGROUND: Hypersensitivity reactions (HRs) and loss of response (LOR) to infliximab (IFX) are related to drug immunogenicity characterized by anti-drug antibodies (ADA). OBJECTIVE: To analyse the timing of ADA appearance, and its relationship with drug levels and clinical outcomes in IFX-treated patients with different diseases. METHODS: Samples were longitudinally collected before each infusion from 91 IFX-treated patients and were assayed for ADA and drug levels by ELISA and for IgE by CAP-system Clinical data were also monitored, regarding efficacy and safety of therapy...
April 13, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29660074/the-effect-of-triple-therapy-on-the-mortality-of-catastrophic-anti-phospholipid-syndrome-patients
#16
Ignasi Rodríguez-Pintó, Gerard Espinosa, Doruk Erkan, Yehuda Shoenfeld, Ricard Cervera
Objectives: The objective of this study was to assess the effect that triple therapy (anticoagulation plus CS plus plasma exchange and/or IVIGs) has on the mortality risk of patients with catastrophic APS (CAPS) included in the CAPS Registry. Methods: Patients from the CAPS Registry were grouped based on their treatments: triple therapy; drugs included in the triple therapy but in different combinations; and none of the treatments included in the triple therapy...
April 11, 2018: Rheumatology
https://www.readbyqxmd.com/read/29660001/translatome-analysis-at-the-egg-to-embryo-transition-in-sea-urchin
#17
Héloïse Chassé, Julie Aubert, Sandrine Boulben, Gildas Le Corguillé, Erwan Corre, Patrick Cormier, Julia Morales
Early embryogenesis relies on the translational regulation of maternally stored mRNAs. In sea urchin, fertilization triggers a dramatic rise in translation activity, necessary for the onset of cell division. Here, the full spectrum of the mRNAs translated upon fertilization was investigated by polysome profiling and sequencing. The translatome of the early sea urchin embryo gave a complete picture of the polysomal recruitment dynamics following fertilization. Our results indicate that only a subset of maternal mRNAs were selectively recruited onto polysomes, with over-represented functional categories in the translated set...
April 6, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29659922/chronology-of-the-intrapuparial-development-of-the-blowfly-chrysomya-albiceps-diptera-calliphoridae-application-in-forensic-entomology
#18
Mônica Salazar-Souza, Márcia S Couri, Valeria M Aguiar
Insects display different patterns of development, and blow flies have one of the most specialized patterns of intrapuparial development of all. In forensic entomology, pupae can be used as a tool to estimate the minimum postmortem time interval (minPMI). We analyzed the intrapuparial development of Chrysomya albiceps (Diptera: Caloricidade), whose larvae had been fed pig lungs and reared in a climate-controlled room at 28°C day/26°C night, 70 ± 10% RH, and 12 h of photophase and monitored daily. After the third-instar larvae abandoned their diet, the process of pupariation and pupation was monitored...
April 12, 2018: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29659911/comparative-bio-efficacy-and-synergism-of-new-generation-polyfluorobenzyl-and-conventional-pyrethroids-against-culex-quinquefasciatus-diptera-culicidae
#19
Manas Sarkar, Ambadas Akulwad, Rajendra Kshirsagar, Siva Muthukrishnan
Intensive exposure to insecticides has resulted in the evolution of insecticide resistance in the mosquitoes. We tested the bio-efficacy of two Culex quinquefasciatus Say (Diptera: Culicidae) laboratory strains differentially bio-responsive to pyrethroids to understand the comparative efficacy of different polyfluorobenzyle and conventional pyrethroid molecules and the role of piperonyl butoxide (PBO) in synergizing these molecules in increased tolerance of mosquitoes to these molecules. We have taken deltamethrin (α-cyano pyrethroid with phenoxybenzyl moiety); permethrin (phenoxybenzyl pyrethroid without an α-cyano group); transfluthrin, dimefluthrin, metofluthrin, and meperfluthrin (polyfluorinated benzyl compounds); and prallethrin (modified cyclopentadienone compound) for this study...
April 12, 2018: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29658398/live-cell-imaging-reveals-the-dynamics-and-function-of-single-telomere-terra-molecules-in-cancer-cells
#20
Laura Avogaro, Emmanuelle Querido, Myriam Dalachi, Michael F Jantsch, Pascal Chartrand, Emilio Cusanelli
Telomeres cap the ends of eukaryotic chromosomes, protecting them from degradation and erroneous recombination events which may lead to genome instability. Telomeres are transcribed giving rise to telomeric repeat-containing RNAs, called TERRA. The TERRA long noncoding RNAs have been proposed to play important roles in telomere biology, including heterochromatin formation and telomere length homeostasis. While TERRA RNAs are predominantly nuclear and localize at telomeres, little is known about the dynamics and function of TERRA molecules expressed from individual telomeres...
April 16, 2018: RNA Biology
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