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https://www.readbyqxmd.com/read/27933180/serum-levels-of-immunoglobulins-and-severity-of-community-acquired-pneumonia
#1
Mari C de la Torre, Pere Torán, Mateu Serra-Prat, Elisabet Palomera, Estel Güell, Ester Vendrell, Joan Carles Yébenes, Antoni Torres, Jordi Almirall
INSTRUCTION: There is evidence of a relationship between severity of infection and inflammatory response of the immune system. The objective is to assess serum levels of immunoglobulins and to establish its relationship with severity of community-acquired pneumonia (CAP) and clinical outcome. METHODS: This was an observational and cross-sectional study in which 3 groups of patients diagnosed with CAP were compared: patients treated in the outpatient setting (n=54), patients requiring in-patient care (hospital ward) (n=173), and patients requiring admission to the intensive care unit (ICU) (n=191)...
2016: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/27932437/reverse-fluorescein-cap-sign-of-cavernous-haemangioma-of-optic-nerve-on-oct-angiography
#2
Padmaja Kumari Rani, Hari Kumar Peguda, Swathi Kaliki, Jay Chhablani
No abstract text is available yet for this article.
December 8, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27931441/policy-on-third-party-fee-capping-of-non-covered-services
#3
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Pediatric Dentistry
https://www.readbyqxmd.com/read/27931388/effects-of-pollution-on-freshwater-organisms
#4
B S Choudri, Mahad Baawain
This review includes works published in the general scientific literature during 2015 on the effects of anthropogenic pollutants on freshwater organisms. It begins with two broad sections: research reviews and broad field studies and surveys. This is followed by reviews of research categorized in sections to reflect the pollutant class. These sections include wastewater, stormwater and non-point source pollution, nutrients, sediment cap materials and suspended clays, botanical extracts, surfactants, metals, persistent organic pollutants, pharmaceuticals, endocrine disruptors, pesticides, petroleum hydrocarbons and polycyclic aromatic hydrocarbons (PAHs), ionic liquids, and nanomaterials...
October 2016: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/27930861/functional-mri-in-seven-borderline-cochlear-implant-candidates-a-preliminary-research-study
#5
F Wagner, S Weder, M D Caversaccio, A Federspiel, R Wiest, P Senn
The indications for cochlear implants (CIs) are constantly expanding, as are the numbers of patients who are not ideal or classical CI candidates. For these patients, a careful decision-making process is needed to minimize the risk of poor outcomes. Preoperatively, it may be unclear whether they will benefit from an implantation. As conventionally performed hearing tests (i.e. subjective and electrophysiological examinations, stapedial reflex testing) have limitations, further objective and effective methods for assessment of the central auditory pathway (CAP) are required [1-3]...
December 8, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27930670/ku-binding-on-telomeres-occurs-at-sites-distal-from-the-physical-chromosome-ends
#6
Mélanie V Larcher, Emeline Pasquier, R Stephen MacDonald, Raymund J Wellinger
The Ku complex binds non-specifically to DNA breaks and ensures repair via NHEJ. However, Ku is also known to bind directly to telomeric DNA ends and its presence there is associated with telomere capping, but avoiding NHEJ. How the complex discriminates between a DNA break and a telomeric extremity remains unknown. Our results using a tagged Ku complex, or a chromosome end capturing method, in budding yeast show that yKu association with telomeres can occur at sites distant from the physical end, on sub-telomeric elements, as well as on interstitial telomeric repeats...
December 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27929192/elucidating-the-influence-of-materials-binding-peptide-sequence-on-au-surface-interactions-and-colloidal-stability-of-au-nanoparticles
#7
Zak E Hughes, Michelle A Nguyen, Yue Li, Mark T Swihart, Tiffany R Walsh, Marc R Knecht
Peptide-mediated synthesis and assembly of nanostructures opens new routes to functional inorganic/organic hybrid materials. However, understanding of the many factors that influence the interaction of biomolecules, specifically peptides, with metal surfaces remains limited. Understanding of the relationship between peptide sequence and resulting binding affinity and configurations would allow predictive design of peptides to achieve desired peptide/metal interface characteristics. Here, we measured the kinetics and thermodynamics of binding on a Au surface for a series of peptide sequences designed to probe specific sequence and context effects...
December 8, 2016: Nanoscale
https://www.readbyqxmd.com/read/27928779/how-antibiotics-should-be-prescribed-to-hospitalized-elderly-patients-with-community-acquired-pneumonia
#8
Forest W Arnold
Elderly patients hospitalized with community-acquired pneumonia (CAP) should be administered antimicrobials in the emergency department prior to transfer to the ward or intensive care unit (ICU). For ward patients, a β-lactam with a macrolide or a respiratory fluoroquinolone alone should be given to cover typical and atypical pathogens. For ICU patients, a β-lactam with either a macrolide or a fluoroquinolone should be given. Other regimens are indicated if methicillin-resistant Staphylococcus aureus or Pseudomonas aeruginosa is a concern...
December 7, 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27928609/characterization-of-phthalocyanine-functionalized-quantum-dots-by-dynamic-light-scattering-laser-doppler-and-capillary-electrophoresis
#9
Gonzalo Ramírez-García, David O Oluwole, Siphesihle Robin Nxele, Fanny d'Orlyé, Tebello Nyokong, Fethi Bedioui, Anne Varenne
In this work, we characterized different phtalocyanine-capped core/shell/shell quantum dots (QDs) in terms of stability, ζ-potential, and size at various pH and ionic strengths, by means of capillary electrophoresis (CE), and compared these results to the ones obtained by laser Doppler electrophoresis (LDE) and dynamic light scattering (DLS). The effect of the phthalocyanine metallic center (Zn, Al, or In), the number (one or four), and nature of substituents (carboxyphenoxy- or sulfonated-) of functionalization on the phthalocyanine physicochemical properties were evaluated...
December 7, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27928157/autoinflammatory-diseases-new-diagnostic-criteria-for-caps-turning-horses-into-zebras
#10
Claas Hinze, Dirk Foell
No abstract text is available yet for this article.
December 8, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27928102/cytotoxicity-and-biocompatibility-of-resin-free-and-resin-modified-direct-pulp-capping-materials-a-state-of-the-art-review
#11
Liang Chen, Byoung In Suh
Direct pulp capping is the placement of a dental material directly over exposed pulp to prevent dental pulp from dying and avoid the need for root canal treatments. Calcium hydroxide and calcium silicates/mineral trioxide aggregates (MTA) have been commonly used for direct pulp capping with great success clinically. In recent years, resin-modified calcium hydroxide and calcium silicates have been developed with the advantages of precise placement, command set, and superior physical strength. As pulp capping materials would be in direct contact with the pulp, the cytotoxicity and biocompatibility is of particular importance in order to avoid pulp irritation and maintain pulp vitality...
December 6, 2016: Dental Materials Journal
https://www.readbyqxmd.com/read/27928055/minimum-noise-production-of-translation-factor-eif4g-maps-to-a-mechanistically-determined-optimal-rate-control-window-for-protein-synthesis
#12
Xiang Meng, Helena Firczuk, Paola Pietroni, Richard Westbrook, Estelle Dacheux, Pedro Mendes, John E G McCarthy
Gene expression noise influences organism evolution and fitness. The mechanisms determining the relationship between stochasticity and the functional role of translation machinery components are critical to viability. eIF4G is an essential translation factor that exerts strong control over protein synthesis. We observe an asymmetric, approximately bell-shaped, relationship between the average intracellular abundance of eIF4G and rates of cell population growth and global mRNA translation, with peak rates occurring at normal physiological abundance...
December 7, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27927641/genetic-architecture-distinguishes-systemic-juvenile-idiopathic-arthritis-from-other-forms-of-juvenile-idiopathic-arthritis-clinical-and-therapeutic-implications
#13
Michael J Ombrello, Victoria L Arthur, Elaine F Remmers, Anne Hinks, Ioanna Tachmazidou, Alexei A Grom, Dirk Foell, Alberto Martini, Marco Gattorno, Seza Özen, Sampath Prahalad, Andrew S Zeft, John F Bohnsack, Norman T Ilowite, Elizabeth D Mellins, Ricardo Russo, Claudio Len, Maria Odete E Hilario, Sheila Oliveira, Rae S M Yeung, Alan M Rosenberg, Lucy R Wedderburn, Jordi Anton, Johannes-Peter Haas, Angela Rosen-Wolff, Kirsten Minden, Klaus Tenbrock, Erkan Demirkaya, Joanna Cobb, Elizabeth Baskin, Sara Signa, Emily Shuldiner, Richard H Duerr, Jean-Paul Achkar, M Ilyas Kamboh, Kenneth M Kaufman, Leah C Kottyan, Dalila Pinto, Stephen W Scherer, Marta E Alarcón-Riquelme, Elisa Docampo, Xavier Estivill, Ahmet Gül, Carl D Langefeld, Susan Thompson, Eleftheria Zeggini, Daniel L Kastner, Patricia Woo, Wendy Thomson
OBJECTIVES: Juvenile idiopathic arthritis (JIA) is a heterogeneous group of conditions unified by the presence of chronic childhood arthritis without an identifiable cause. Systemic JIA (sJIA) is a rare form of JIA characterised by systemic inflammation. sJIA is distinguished from other forms of JIA by unique clinical features and treatment responses that are similar to autoinflammatory diseases. However, approximately half of children with sJIA develop destructive, long-standing arthritis that appears similar to other forms of JIA...
December 7, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27927236/chronic-infantile-neurological-cutaneous-and-articular-cinca-syndrome-a-review
#14
REVIEW
Martina Finetti, Alessia Omenetti, Silvia Federici, Roberta Caorsi, Marco Gattorno
INTRODUCTION: The Chronic Infantile Neurological Cutaneous and Articular (CINCA, or Neonatal-onset multisystem inflammatory disease NOMID) is a rare autoinflammatory disease identified in 1987 by Prieur et al., typically characterized by the triad of skin rash, arthropathy and central nervous system manifestations. It represents the most severe phenotype of the cryopyrin-associated periodic syndrome (CAPS). CLINICAL DESCRIPTION AND ETIOLOGY: The syndrome is due to autosomal dominant gain of function mutations in NLRP3, which encodes a key component of the innate immunity that regulates the activation and secretion of interleukin (IL)-1β...
December 7, 2016: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/27925558/letter
#15
Elaine Blisset
In answer to your Readers' Panel question 'Is the 1% pay cap destroying nurses' morale?' (opinion, 23 November), it already has. Experienced nurses are leaving and it is almost impossible to fill their posts. Hence the shortage of nurses.
December 7, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27925507/haematopoietic-effects-of-angelica-sinensis-root-cap-polysaccharides-against-lisinopril-induced-anaemia-in-albino-rats
#16
Fryal Younas, Bilal Aslam, Faqir Muhammad, Mashkoor Mohsin, Ahmad Raza, Muhammad Naeem Faisal, Shamshud-Ul- Hassan, Wafa Majeed
CONTEXT: Angelica sinensis L. (Umbelliferae) has medicinal properties. OBJECTIVES: The present study evaluates the haematopoietic effects of A. sinensis polysaccharides (ASP) against lisinopril-induced anaemia. MATERIALS AND METHODS: Thirty healthy adult male albino rats were randomly divided into five groups (n = 6). Group I was control group. Group II was treated with angiotensin-converting enzyme inhibitor (ACEI, 20 mg/kg/day) to induce anaemia...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27925418/white-light-emitting-carbon-dots-prepared-by-the-electrochemical-exfoliation-of-graphite
#17
Aji A Anappara, Julin Joseph
Here we report single-step synthesis of white-light emitting carbon dots (CDs) through a green, facile and cheap electrochemical route using graphite rods as the carbon source. Under UV-excitation, the aqueous dispersion of as-synthesized CDs exhibited broad-band emission which covers a significant fraction of visible spectrum; owing to the heterogeneity in the particle-size and surface-functional groups. The CDs were further explored for their potential as UV-to-visible color-convertor under remote-phosphor technology by capping a 365 nm UV-LED chip with CDs-loaded PMMA to obtain color parameters: CIE (0...
December 7, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/27925415/utilization-of-red-light-emitting-cdte-nanoparticles-for-the-trace-level-detection-of-harmful-herbicides-in-adulterated-food-and-agricultural-crops
#18
Nilanjan Dey, Deepa Bhagat, Durgadas Cherukaraveedu, Santanu Bhattacharya
Red-light-emitting water-soluble semiconducting quantum dots (QDs) were synthesized by using a wide variety of commercially available thiol-type capping agents. QDs with a negatively charged nanosurface showed excellent selectivity for paraquat (PQ) at pH 7.4 over other commonly encountered pesticides/herbicides, including diquat (DQ). The presence of a 4,4'-bis-pyridinium unit in PQ enabled it to initiate long-range aggregation, thereby leading to the formation of nanostructures with excellent emission-quenching behavior...
November 7, 2016: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/27924983/detection-of-the-tuberculosis-antigenic-marker-mannose-capped-lipoarabinomannan-in-pretreated-serum-by-surface-enhanced-raman-scattering
#19
Alexis C Crawford, Lars B Laurentius, Timothy S Mulvihill, Jennifer H Granger, John S Spencer, Delphi Chatterjee, Kimberly E Hanson, Marc D Porter
The ability to detect tuberculosis (TB) continues to be a global health care priority. This paper describes the development and preliminary assessment of the clinical accuracy of a heterogeneous immunoassay that integrates a serum pretreatment process with readout by surface-enhanced Raman scattering (SERS) for the low-level detection of mannose-capped lipoarabinomannan (ManLAM). ManLAM is a major virulence factor in the infectious pathology of Mycobacterium tuberculosis (Mtb) that has been found in the serum and other body fluids of infected patients...
December 7, 2016: Analyst
https://www.readbyqxmd.com/read/27924950/molecular-gated-nanoporous-anodic-alumina-for-the-detection-of-cocaine
#20
Àngela Ribes, Elisabet Xifré-Pérez, Elena Aznar, Félix Sancenón, Teresa Pardo, Lluís F Marsal, Ramόn Martínez-Máñez
We present herein the use of nanoporous anodic alumina (NAA) as a suitable support to implement "molecular gates" for sensing applications. In our design, a NAA support is loaded with a fluorescent reporter (rhodamine B) and functionalized with a short single-stranded DNA. Then pores are blocked by the subsequent hybridisation of a specific cocaine aptamer. The response of the gated material was studied in aqueous solution. In a typical experiment, the support was immersed in hybridisation buffer solution in the absence or presence of cocaine...
December 7, 2016: Scientific Reports
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