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https://www.readbyqxmd.com/read/29785940/metabolic-effects-safety-and-acceptability-of-very-low-calorie-ketogenic-dietetic-scheme-on-candidates-for-bariatric-surgery
#1
Vincenzo Pilone, Salvatore Tramontano, Michele Renzulli, Mafalda Romano, Luigi Cobellis, Tiziano Berselli, Luigi Schiavo
BACKGROUND: Previous studies have demonstrated significant advantages from a preoperative dietetic regimen for candidates to bariatric procedure. OBJECTIVES: Evaluation of safety, efficacy, and acceptability of a very low-calorie ketogenic diet in patients before bariatric surgery. SETTING: University Hospital. METHODS: A standardized 30-day sequential preoperative diet regimen has been analyzed, optimizing metabolic response with gradual carbohydrate reintroduction...
March 21, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29777386/substrate-metabolism-during-ironman-triathlon-different-horses-on-the-same-courses
#2
Ed Maunder, Andrew E Kilding, Daniel J Plews
Ironman triathlons are ultra-endurance events of extreme duration. The performance level of those competing varies dramatically, with elite competitors finishing in ~ 8:00:00, and lower performing amateurs finishing in ~ 14-15:00:00. When applying appropriate values for swimming, cycling and running economies to these performance times, it is demonstrated that the absolute energy cost of these events is high, and the rate of energy expenditure increases in proportion with the athlete's competitive level...
May 18, 2018: Sports Medicine
https://www.readbyqxmd.com/read/29743883/treatment-of-diabetic-mice-with-a-combination-of-ketogenic-diet-and-aerobic-exercise-via-modulations-of-ppars-gene-programs
#3
Qiang Zhang, Lingyan Xu, Jie Xia, Dongmei Wang, Min Qian, Shuzhe Ding
Type 2 diabetes is a prevalent chronic disease arising as a serious public health problem worldwide. Diet intervention is considered to be a critical strategy in glycemic control of diabetic patients. Recently, the low-carbohydrate ketogenic diet is shown to be effective in glycemic control and weight loss. However, hepatic lipid accumulation could be observed in mice treated with ketogenic diet. On the other hand, exercise is a well-known approach for treating nonalcoholic fatty liver disease. We thus hypothesize that the combination of ketogenic diet and exercise could improve insulin sensitivity, while minimizing adverse effect of hepatic steatosis...
2018: PPAR Research
https://www.readbyqxmd.com/read/29737587/the-glycaemic-benefits-of-a-very-low-carbohydrate-ketogenic-diet-in-adults-with-type-1-diabetes-mellitus-may-be-opposed-by-increased-hypoglycaemia-risk-and-dyslipidaemia
#4
Z Z X Leow, K J Guelfi, E A Davis, T W Jones, P A Fournier
AIMS: To investigate whether very-low-carbohydrate high-fat diets, typical of ketogenic diets, can improve glycaemic control without causing any ill health effects in adults with Type 1 diabetes. METHODS: In this observational study, 11 adults with Type 1 diabetes (seven men, four women, mean ± sd age 36.1± 6.8 years, mean ± sd duration of diabetes 12.8 ± 10.3 years), who followed a ketogenic diet (< 55 g carbohydrate per day) for a mean ± sd of 2.6 ± 3...
May 8, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29716886/authors-reply-comment-on-an-online-intervention-comparing-a-very-low-carbohydrate-ketogenic-diet-and-lifestyle-recommendations-versus-a-plate-method-diet-in-overweight-individuals-with-type-2-diabetes-a-randomized-controlled-trial
#5
Laura Saslow, Ashley E Mason, Sarah Kim, Veronica Goldman, Robert Ploutz-Snyder, Hovig Bayandorian, Jennifer Daubenmier, Frederick M Hecht, Judith T Moskowitz
No abstract text is available yet for this article.
May 1, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29716884/comment-on-an-online-intervention-comparing-a-very-low-carbohydrate-ketogenic-diet-and-lifestyle-recommendations-versus-a-plate-method-diet-in-overweight-individuals-with-type-2-diabetes-a-randomized-controlled-trial
#6
https://www.readbyqxmd.com/read/29689338/the-ketogenic-diet-in-disease-and-development
#7
REVIEW
Denis Barry, Sarah Ellul, Lindsey Watters, David Lee, Robert Haluska, Robin White
The ketogenic diet, low in carbohydrates and high in fat, was initially designed to reduce seizure onset in epilepsy. More recent evidence has shown its effectiveness in the treatment of movement and psychological disorders, and in general health maintenance. The cellular significance of ketone body metabolism during development and in the adult central nervous system is being revealed; however, the effects of replacing glucose with ketone bodies as the brains primary energy source especially in pregnancy are not fully understood...
April 21, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29644487/therapeutic-use-of-carbohydrate-restricted-diets-in-an-autistic-child-a-case-report-of-clinical-and-18fdg-pet-findings
#8
Iwona Żarnowska, Beata Chrapko, Grażyna Gwizda, Anna Nocuń, Krystyna Mitosek-Szewczyk, Maciej Gasior
The ketogenic diet (KD) is a high-fat, adequate-protein, and low-carbohydrate diet that has been used successfully in the treatment of refractory epilepsies for almost 100 years. There has been accumulating evidence to show that the KD may provide a therapeutic benefit in autism spectrum disorders, albeit by a yet-unknown mechanism. We report a case of a 6-year-old patient with high-functioning autism and subclinical epileptic discharges who responded poorly to several behavioural and psychopharmacological treatments...
April 11, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29619799/low-carbohydrate-ketogenic-diet-impairs-anaerobic-exercise-performance-in-exercise-trained-women-and-men-a-randomized-sequence-crossover-trial
#9
Kymberly A Wroble, Morgan N Trott, George G Schweitzer, Rabia S Rahman, Patrick V Kelly, Edward P Weiss
BACKGROUND: Low-carbohydrate, ketogenic diets cause mild, sub-clinical systemic acidosis. Anaerobic exercise performance is limited by acidosis. Therefore, we evaluated the hypothesis that a low-carbohydrate, ketogenic diet impairs anaerobic exercise performance, as compared to a high-carbohydrate diet. METHODS: Sixteen men and women (BMI, 23±1 kg/m2, age 23±1 yr) participated in a randomized-sequence, counterbalanced crossover study in which they underwent exercise testing after four days of either a low-carbohydrate, ketogenic diet (LC; <50 g/day and <10% of energy from carbohydrates) or a high-carbohydrate diet (HC; 6-10 g/kg/day carbohydrate)...
April 4, 2018: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29607218/nutritional-ketosis-and-mitohormesis-potential-implications-for-mitochondrial-function-and-human-health
#10
REVIEW
Vincent J Miller, Frederick A Villamena, Jeff S Volek
Impaired mitochondrial function often results in excessive production of reactive oxygen species (ROS) and is involved in the etiology of many chronic diseases, including cardiovascular disease, diabetes, neurodegenerative disorders, and cancer. Moderate levels of mitochondrial ROS, however, can protect against chronic disease by inducing upregulation of mitochondrial capacity and endogenous antioxidant defense. This phenomenon, referred to as mitohormesis, is induced through increased reliance on mitochondrial respiration, which can occur through diet or exercise...
2018: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/29556949/more-sugar-no-thank-you-the-elusive-nature-of-low-carbohydrate-diets
#11
REVIEW
Dario Giugliano, Maria Ida Maiorino, Giuseppe Bellastella, Katherine Esposito
In the past decades, dietary guidelines focused on reducing saturated fat as the primary strategy for cardiovascular disease prevention, neglecting the many other potential effects of diet on health, in particular the harmful effects of sugar. A greater intake of soft drinks (sugar-sweetened beverages), for example, is associated with a 44% increased prevalence of metabolic syndrome, a higher risk of obesity, and a 26% increased risk of developing diabetes mellitus. Carbohydrates comprise around 55% of the typical western diet, ranging from 200 to 350 g/day in relation to a person's overall caloric intake...
March 19, 2018: Endocrine
https://www.readbyqxmd.com/read/29541907/overweight-and-diabetes-prevention-is-a-low-carbohydrate-high-fat-diet-recommendable
#12
REVIEW
Fred Brouns
In the past, different types of diet with a generally low-carbohydrate content (< 50-< 20 g/day) have been promoted, for weight loss and diabetes, and the effectiveness of a very low dietary carbohydrate content has always been a matter of debate. A significant reduction in the amount of carbohydrates in the diet is usually accompanied by an increase in the amount of fat and to a lesser extent, also protein. Accordingly, using the term "low carb-high fat" (LCHF) diet is most appropriate...
June 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29537059/-update-on-the-adverse-effects-during-therapy-with-a-ketogenic-diet-in-paediatric-refractory-epilepsy
#13
REVIEW
M Armeno, C Araujo, B Sotomontesano, R H Caraballo
INTRODUCTION: The ketogenic diet is a non-pharmacological treatment that has been used as a therapeutic alternative for the management of refractory epilepsy since 1921. It is a diet, high in fats and low in carbohydrates, which is used to treat paediatric refractory epilepsy, and is effective in around 50% of the patients that begin to follow it. It is a nutrition plan that is imbalanced in terms of both macro- and micro-nutrients, which can give rise to nutritional deficits in energy, proteins, minerals and vitamins, as well as an excess of lipids...
March 16, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29470430/metabolic-responses-in-endothelial-cells-following-exposure-to-ketone-bodies
#14
Erika Meroni, Nadia Papini, Franca Criscuoli, Maria C Casiraghi, Luca Massaccesi, Nicoletta Basilico, Daniela Erba
The ketogenic diet (KD) is a high-fat, low-carbohydrate diet based on the induction of the synthesis of ketone bodies (KB). Despite its widespread use, the systemic impact of KD is not completely understood. The purpose of this study was to evaluate the effects of physiological levels of KB on HMEC-1 endothelial cells. To this aim, DNA oxidative damage and the activation of Nrf2, a known transcriptional factor involved in cell responses to oxidative stress, were assessed. The exposure of cells to KB exerted a moderate genotoxic effect, measured by a significant increase in DNA oxidative damage...
February 22, 2018: Nutrients
https://www.readbyqxmd.com/read/29463034/chronic-ketogenic-low-carbohydrate-high-fat-diet-has-minimal-effects-on-acid-base-status-in-elite-athletes
#15
Amelia J Carr, Avish P Sharma, Megan L Ross, Marijke Welvaert, Gary J Slater, Louise M Burke
Although short (up to 3 days) exposure to major shifts in macronutrient intake appears to alter acid-base status, the effects of sustained (>1 week) interventions in elite athletes has not been determined. Using a non-randomized, parallel design, we examined the effect of adaptations to 21 days of a ketogenic low carbohydrate high fat (LCHF) or periodized carbohydrate (PCHO) diet on pre- and post-exercise blood pH, and concentrations of bicarbonate (HCO₃- ) and lactate (La- ) in comparison to a high carbohydrate (HCHO) control...
February 18, 2018: Nutrients
https://www.readbyqxmd.com/read/29454073/the-accumulation-of-assembly-intermediates-of-the-mitochondrial-complex-i-matrix-arm-is-reduced-by-limiting-glucose-uptake-in-a-neuronal-like-model-of-melas-syndrome
#16
Guillaume Geffroy, Rayane Benyahia, Samuel Frey, Valerie Desquiret-Dumas, Naig Gueguen, Celine Bris, Sophie Belal, Aurore Inisan, Aurelie Renaud, Arnaud Chevrollier, Daniel Henrion, Dominique Bonneau, Franck Letournel, Guy Lenaers, Pascal Reynier, Vincent Procaccio
Ketogenic diet (KD) which combined carbohydrate restriction and the addition of ketone bodies has emerged as an alternative metabolic intervention used as an anticonvulsant therapy or to treat different types of neurological or mitochondrial disorders including MELAS syndrome. MELAS syndrome is a severe mitochondrial disease mainly due to the m.3243A > G mitochondrial DNA mutation. The broad success of KD is due to multiple beneficial mechanisms with distinct effects of very low carbohydrates and ketones...
May 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29434537/how-can-a-ketogenic-diet-improve-motor-function
#17
REVIEW
Charlotte Veyrat-Durebex, Pascal Reynier, Vincent Procaccio, Rudolf Hergesheimer, Philippe Corcia, Christian R Andres, Hélène Blasco
A ketogenic diet (KD) is a normocaloric diet composed by high fat (80-90%), low carbohydrate, and low protein consumption that induces fasting-like effects. KD increases ketone body (KBs) production and its concentration in the blood, providing the brain an alternative energy supply that enhances oxidative mitochondrial metabolism. In addition to its profound impact on neuro-metabolism and bioenergetics, the neuroprotective effect of specific polyunsaturated fatty acids and KBs involves pleiotropic mechanisms, such as the modulation of neuronal membrane excitability, inflammation, or reactive oxygen species production...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29431534/organisation-of-dietary-control-for-nutrition-training-intervention-involving-periodized-carbohydrate-cho-availability-and-ketogenic-low-cho-high-fat-lchf-diet
#18
Joanne G Mirtschin, Sara F Forbes, Louise E Cato, Ida A Heikura, Nicki Strobel, Rebecca Hall, Louise M Burke
We describe the implementation of a 3-week dietary intervention in elite race walkers at the Australian Institute of Sport, with a focus on the resources and strategies needed to accomplish a complex study of this scale. Interventions involved: traditional guidelines of high carbohydrate (CHO) availability for all training sessions (HCHO); a periodized CHO diet which integrated sessions with low CHO and high CHO availability within the same total CHO intake, and a ketogenic low-CHO high-fat diet (LCHF). 7-day menus and recipes were constructed for a communal eating setting to meet nutritional goals as well as individualized food preferences and special needs...
February 12, 2018: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29414764/low-ketolytic-enzyme-levels-in-tumors-predict-ketogenic-diet-responses-in-cancer-cell-lines-in-vitro-and-in-vivo
#19
Jie Zhang, Ping-Ping Jia, Qing-Le Liu, Ming-Hua Cong, Yun Gao, Han-Ping Shi, Wei-Nan Yu, Ming-Yong Miao
The ketogenic diet (KD) is a high-fat, very-low-carbohydrate diet that triggers a fasting state by decreasing glucose and increasing ketone bodies, such as β-hydroxybutyrate (βHB). In experimental models and clinical trials, the KD has shown anti-tumor effects, possibly by reducing energy supplies to cells, which damage the tumor microenvironment and inhibit tumor growth. Here, we determined expression levels of genes encoding the ketolytic enzymes 3-hydroxybutyrate dehydrogenase 1 (BDH1) and succinyl-CoA: 3-oxoacid CoA transferase 1 (OXCT1) in 33 human cancer cell lines...
April 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29361967/the-effect-of-a-ketogenic-diet-versus-a-high-carbohydrate-low-fat-diet-on-sleep-cognition-thyroid-function-and-cardiovascular-health-independent-of-weight-loss-study-protocol-for-a-randomized-controlled-trial
#20
Stella Iacovides, Rebecca M Meiring
BACKGROUND: Many physiological health benefits observed after following a ketogenic diet (KD) can be attributed to the associated weight loss. The KD has become more prominent as a popular health choice, not only in obese/overweight individuals, but also in healthy adults. The study aims to determine the effects of a KD, independent of weight loss, on various aspects of physiological health including: sleep, thyroid function, cognition, and cardio-metabolic health. The study will also aim to determine whether a change in basal metabolic rate may be associated with any changes observed...
January 23, 2018: Trials
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