keyword
MENU ▼
Read by QxMD icon Read
search

Skeletal muscle blood flow

keyword
https://www.readbyqxmd.com/read/29775407/effect-of-healthy-aging-and-sex-on-middle-cerebral-artery-blood-velocity-dynamics-during-moderate-intensity-exercise
#1
Jaimie L Ward, Jesse C Craig, Yumei Liu, Eric Dennis Vidoni, Rebecca Malesky, David C Poole, Sandra A Billinger
Cerebral blood flow (CBF) velocity measured in the middle cerebral artery (MCAV ) increases with finite kinetics during moderate intensity exercise and both the amplitude and dynamics of the response provide invaluable insights into the controlling mechanisms. The MCAV response following exercise onset is well fit to an exponential model in young individuals but remains to be characterized in their older counterparts. The responsiveness of vasomotor control degrades with advancing age, especially in skeletal muscle, and we tested the hypothesis that older subjects would evince a slower and reduced MCAV response to exercise...
May 18, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29763373/oral-glucose-challenge-impairs-skeletal-muscle-microvascular-blood-flow-in-healthy-people
#2
Ryan D Russell, Donghua Hu, Timothy Greenaway, James E Sharman, Stephen Rattigan, Stephen M Richards, Michelle A Keske
Skeletal muscle microvascular (capillary) blood flow increases in the post-prandial state or during insulin infusion due to dilation of pre-capillary arterioles to augment glucose disposal. This effect occurs independent of changes in large artery function. However, acute hyperglycemia impairs vascular function, causes insulin to vasoconstrict pre-capillary arterioles, and causes muscle insulin resistance in vivo. We hypothesize that acute hyperglycemia impairs post-prandial muscle microvascular perfusion, without disrupting normal large artery hemodynamics, in healthy humans...
May 15, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29756164/methods-for-the-determination-of-skeletal-muscle-blood-flow-development-strengths-and-limitations
#3
REVIEW
Lasse Gliemann, Stefan P Mortensen, Ylva Hellsten
Since the first measurements of limb blood flow at rest and during nerve stimulation were conducted in the late 1800s, a number of methods have been developed for the determination of limb and skeletal muscle blood flow in humans. The methods, which have been applied in the study of aspects such as blood flow regulation, oxygen uptake and metabolism, differ in terms of strengths and degree of limitations but most have advantages for specific settings. The purpose of this review is to describe the origin and the basic principles of the methods, important aspects and requirements of the procedures...
May 14, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29722627/effect-of-dietary-nitrate-supplementation-on-conduit-artery-blood-flow-muscle-oxygenation-and-metabolic-rate-during-handgrip-exercise
#4
Jesse C Craig, Ryan M Broxterman, Joshua R Smith, Jason David Allen, Thomas J Barstow
Dietary nitrate supplementation has positive effects on mitochondrial and muscle contractile efficiency during large muscle mass exercise in humans, and on skeletal muscle blood flow (Q̇) in rats. However, concurrent measurement of these effects has not been performed in humans. Therefore, we assessed the influence of nitrate supplementation on Q̇ and muscle oxygenation characteristics during moderate (40%peak) and severe (85%peak) intensity handgrip exercise in a randomized, double-blind, crossover-design...
May 3, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29722620/elevated-extracellular-potassium-prior-to-muscle-contraction-reduces-onset-and-steady-state-exercise-hyperemia-in-humans
#5
Janée D Terwoord, Christopher M Hearon, Gary J Luckasen, Jennifer C Richards, Michael J Joyner, Frank A Dinenno
The increase in interstitial potassium (K+ ) during muscle contractions is thought to be a vasodilatory signal that contributes to exercise hyperemia. To determine the role of extracellular K+ in exercise hyperemia, we perfused skeletal muscle with K+ prior to contractions such that the effect of any endogenously-released K+ would be minimized. We tested the hypothesis that local, intra-arterial infusion of potassium chloride (KCl) at rest would impair vasodilation in response to subsequent rhythmic handgrip exercise in humans...
May 3, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29708589/impaired-modulation-of-postjunctional-%C3%AE-1-but-not-%C3%AE-2-adrenergic-vasoconstriction-in-contracting-forearm-muscle-of-postmenopausal-women
#6
Nicholas T Kruse, William E Hughes, Kenichi Ueda, Satoshi Hanada, Andrew J Feider, Erika Iwamoto, Joshua M Bock, Darren P Casey
Contraction mediated blunting of postjunctional α-adrenergic vasoconstriction (functional sympatholysis) is attenuated in older males; however, direct confirmation of this effect remains unknown in postmenopausal women (PMW). The present study examined whether PMW exhibit augmented postjunctional α-adrenergic receptor vasoconstriction at rest and during forearm exercise compared to young women (YW). Eight YW (24 ± 1 yrs) and eight PMW (65 ± 1 yrs) completed a series of randomized experimental trials; 1) at rest 2) under high flow (adenosine infusion) conditions and 3) during 6-minutes of forearm exercise at relative (20% of maximum (MVC) and absolute (7 kg) intensities...
April 30, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29668326/effects-of-aging-and-exercise-training-on-leg-hemodynamics-and-oxidative-metabolism-in-the-transition-from-rest-to-steady-state-exercise-role-of-cgmp-signaling
#7
Peter Piil, Tue Smith Jørgensen, Jon Egelund, Nicolai Rytter, Lasse Gliemann, Jens Bangsbo, Ylva Hellsten, Michael Nyberg
Aging is associated with slower skeletal muscle O2 uptake (VO2 ) kinetics; however, the mechanisms underlying this effect of age are unclear. Also, the effects of exercise training in elderly on the initial vascular and metabolic response to exercise remain to be elucidated. We measured leg hemodynamics and oxidative metabolism in the transition from rest to steady state exercise engaging the knee-extensor muscles in young (n=15, 25{plus minus}1 years) and older (n=15, 72{plus minus}1 years) subjects before and after a period of aerobic high-intensity exercise training...
April 18, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29665013/planhab-hypoxia-does-not-worsen-the-impairment-of-skeletal-muscle-oxidative-function-induced-by-bed-rest-alone
#8
Desy Salvadego, Michail E Keramidas, Roger Kölegård, Lorenza Brocca, Stefano Lazzer, Irene Mavelli, Jörn Rittweger, Ola Eiken, Igor B Mekjavic, Bruno Grassi
KEY POINTS: Superposition of hypoxia on 21 day bed rest did not worsen the impairment of skeletal muscle oxidative function induced by bed rest alone. A significant impairment of maximal oxidative performance was identified downstream of cardiovascular O2 delivery, involving both the intramuscular matching between O2 supply and utilization and mitochondrial respiration. These chronic adaptations appear to be relevant in terms of exposure to spaceflights and reduced gravity habitats (Moon or Mars), as characterized by low gravity and hypoxia, in patients with chronic diseases characterized by hypomobility/immobility and hypoxia, as well as in ageing...
April 17, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29663541/eccentric-exercise-increases-circulating-fibroblast-activation-protein-but-not-bioactive-fibroblast-growth-factor-21-in-healthy-humans
#9
Biraj Parmar, Jo E Lewis, Ricardo J Samms, Francis J P Ebling, Christine C Cheng, Andrew C Adams, Joanne Mallinson, Scott Cooper, Tariq Taylor, Reza Ghasemi, Francis B Stephens, Kostas Tsintzas
NEW FINDINGS: What is the central question of this study? The role of FGF21 as an exercise-induced myokine remains controversial. The aim of this study was to determine whether eccentric exercise would augment the release of FGF21 and/or its regulatory enzyme Fibroblast Activation Protein (FAP) from skeletal muscle tissue into the systemic circulation of healthy human volunteers. What is the main finding and its importance? Eccentric exercise does not release total or bioactive FGF21 from human skeletal muscle...
April 16, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29652542/sympathoexcitation-constrains-vasodilation-in-the-human-skeletal-muscle-microvasculature-during-post-occlusive-reactive-hyperemia
#10
Masashi Ichinose, Mikie Nakabayashi, Yumie Ono
We used diffuse correlation spectroscopy (DCS) to investigate sympathetic vasoconstriction, local vasodilation, and integration of these two responses in the skeletal muscle microvasculature of 20 healthy volunteers. DCS probes were placed on the flexor carpi radialis muscle (FC) or the vastus lateralis muscle (VL), and a blood flow index (BFI) was derived continuously. We measured hemodynamic responses during sympathoexcitation induced by forehead cooling, after which the effects of the increased sympathetic tone on vasodilatory responses during post-occlusive reactive hyperemia (PORH) were examined...
April 13, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29629973/the-application-of-blood-flow-restriction-lessons-from-the-laboratory
#11
Kevin T Mattocks, Matthew B Jessee, J Grant Mouser, Scott J Dankel, Samuel L Buckner, Zachary W Bell, Johnny G Owens, Takashi Abe, Jeremy P Loenneke
Blood flow restriction by itself or in combination with exercise has been shown to produce beneficial adaptations to skeletal muscle. These adaptations have been observed across a range of populations, and this technique has become an attractive possibility for use in rehabilitation. Although there are concerns that applying blood flow restriction during exercise makes exercise inherently more dangerous, these concerns appear largely unfounded. Nevertheless, we have advocated that practitioners could minimize many of the risks associated with blood flow-restricted exercise by accounting for methodological factors, such as cuff width, cuff type, and the individual to which blood flow restriction is being applied...
April 2018: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/29623692/daily-muscle-stretching-enhances-blood-flow-endothelial-function-capillarity-vascular-volume-and-connectivity-in-aged-skeletal-muscle
#12
Kazuki Hotta, Bradley J Behnke, Bahram Arjmandi, Payal Ghosh, Bei Chen, Rachael Brooks, Joshua J Maraj, Marcus L Elam, Patrick Maher, Daniel Kurien, Alexandra Churchill, Jaime L Sepulveda, Max B Kabolowsky, Demetra D Christou, Judy M Muller-Delp
KEY POINTS: In aged rats, daily muscle stretching increases blood flow to skeletal muscle during exercise. Daily muscle stretching enhanced endothelium-dependent vasodilatation of skeletal muscle resistance arterioles of aged rats. Angiogenic markers and capillarity increased in response to daily stretching in muscles of aged rats. Muscle stretching performed with a splint could provide a feasible means of improving muscle blood flow and function in elderly patients who cannot perform regular aerobic exercise...
April 5, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29604268/mild-aerobic-training-with-blood-flow-restriction-increases-the-hypertrophy-index-and-musk-in-both-slow-and-fast-muscles-of-old-rats-role-of-pgc-1%C3%AE
#13
Mohammad-Ali Bahreini Pour, Siyavash Joukar, Fariborz Hovanloo, Hamid Najafipour, Vida Naderi, Alireza Raji, Saeed Esmaeili-Mahani
AIMS: Existing evidence emphasize the role of mitochondrial dysfunction in sarcopenia which is revealed as loss of skeletal muscle mass and neuromuscular junction remodeling. We assessed the effect of low-intensity aerobic training along with blood flow restriction on muscle hypertrophy index, muscle-specific kinase (MuSK), a pivotal protein of the neuromuscular junction and Peroxisome proliferator-activated receptor gamma co-activator 1-alpha (PGC-1α) in aged male rats. MAIN METHODS: Animals groups were control (CTL), sham (Sh), leg blood flow restriction (BFR), exercise (Ex), sham + exercise (Sh + Ex), and BFR plus exercise (BFR + Ex) groups...
March 28, 2018: Life Sciences
https://www.readbyqxmd.com/read/29603743/inhibition-of-na-k-atpase-and-k-ir-channels-abolishes-hypoxic-hyperaemia-in-resting-but-not-contracting-skeletal-muscle-of-humans
#14
Matthew L Racine, Anne R Crecelius, Gary J Luckasen, Dennis G Larson, Frank A Dinenno
Exercise hyperaemia in hypoxia is augmented relative to the same exercise intensity in normoxia. During moderate-intensity handgrip exercise, endothelium-derived nitric oxide (NO) and vasodilating prostaglandins (PGs) contribute to ∼50% of the augmented forearm blood flow (FBF) response to hypoxic exercise (HypEx), but the mechanism(s) underlying the remaining response are unclear. We hypothesized that combined inhibition of NO, PGs, Na+ /K+ -ATPase, and inwardly rectifying potassium (KIR ) channels would abolish the augmented hyperaemic response in HypEx...
March 31, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29596016/chronic-interval-exercise-training-prevents-bk-ca-channel-mediated-coronary-vascular-dysfunction-in-aortic-banded-mini-swine
#15
T Dylan Olver, Jenna C Edwards, Brian S Ferguson, Jessica A Hiemstra, Pamela K Thorne, Michael A Hill, Maurice Harold Laughlin, Craig A Emter
Conventional treatments have failed to improve the prognosis of heart failure with preserved ejection fraction (HFpEF) patients. Thus, the purpose of this study was to determine the therapeutic efficacy of chronic interval exercise training (IT) on BKCa channel-mediated coronary vascular function in heart failure. We hypothesized chronic interval exercise training would attenuate pressure overload-induced impairments to coronary BKCa channel-mediated function. A translational large animal model with cardiac features of heart failure with preserved ejection fraction was used to test this hypothesis...
March 29, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29595019/validation-of-diffuse-correlation-spectroscopy-sensitivity-to-nicotinamide-induced-blood-flow-elevation-in-the-murine-hindlimb-using-the-fluorescent-microsphere-technique
#16
Ashley R Proctor, Gabriel A Ramirez, Songfeng Han, Ziping Liu, Tracy M Bubel, Regine Choe
Nicotinamide has been shown to affect blood flow in both tumor and normal tissues, including skeletal muscle. Intraperitoneal injection of nicotinamide was used as a simple intervention to test the sensitivity of noninvasive diffuse correlation spectroscopy (DCS) to changes in blood flow in the murine left quadriceps femoris skeletal muscle. DCS was then compared with the gold-standard fluorescent microsphere (FM) technique for validation. The nicotinamide dose-response experiment showed that relative blood flow measured by DCS increased following treatment with 500- and 1000-mg  /  kg nicotinamide...
March 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29593014/ryanodine-receptor-calcium-leak-in-circulating-b-lymphocytes-as-a-biomarker-in-heart-failure
#17
Alexander Kushnir, Gaetano Santulli, Steven R Reiken, Ellie Coromilas, Sarah J Godfrey, Danielle L Brunjes, Paolo C Colombo, Melana Yuzefpolskaya, Seth I Sokol, Richard N Kitsis, Andrew R Marks
Background -Advances in congestive heart failure (CHF) management depend on biomarkers for monitoring disease progression and therapeutic response. During systole, intracellular Ca2+ is released from the sarcoplasmic reticulum (SR) into the cytoplasm through type 2 ryanodine receptor/Ca2+ release channels (RyR2). In CHF, chronically elevated circulating catecholamine levels cause pathologic remodeling of RyR2 resulting in diastolic SR Ca2+ leak, and decreased myocardial contractility. Similarly, skeletal muscle contraction requires SR Ca2+ release through type-1 ryanodine receptors (RyR1), and chronically elevated catecholamine levels in CHF cause RyR1 mediated SR Ca2+ leak, contributing to myopathy and weakness...
March 28, 2018: Circulation
https://www.readbyqxmd.com/read/29584857/impaired-muscle-efficiency-but-preserved-peripheral-hemodynamics-and-mitochondrial-function-with-advancing-age-evidence-from-exercise-in-the-young-old-and-oldest-old
#18
Gwenael Layec, Joel D Trinity, Corey R Hart, Yann Le Fur, Jia Zhao, Van Reese, Eun-Kee Jeong, Russell S Richardson
Muscle weakness in the elderly has been linked to recurrent falls and morbidity, therefore, elucidating the mechanisms contributing to the loss of muscle function and mobility with advancing age is critical. To this aim, we comprehensively examined skeletal muscle metabolic function and hemodynamics in 11 young (23±2 yrs), 11 old (68±2 yrs), and 10 oldest-old (84±2 yrs) physical activity-matched subjects. Specifically, oxidative stress markers, mitochondrial function and the ATP cost of contraction as well as peripheral hemodynamics were assessed during dynamic plantar flexion exercise at 40% of maximal work rate (WRmax)...
March 23, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29577514/gene-expression-profiles-of-ion-channels-and-receptors-in-mouse-resistance-arteries-effects-of-cell-type-vascular-bed-and-age
#19
Erika M Boerman, Sen Sidharth, Rebecca L Shaw, Trupti Joshi, Steven S Segal
OBJECTIVE: Receptors and ion channels of smooth muscle cells (SMCs) and endothelial cells (ECs) are integral to the regulation of vessel diameter and tissue blood flow. Physiological roles of ion channels and receptors in skeletal muscle and mesenteric arteries have been identified however their gene expression profiles are undefined. We tested the hypothesis that expression profiles for ion channels and receptors governing vascular reactivity vary with cell type, vascular bed and age...
March 25, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29575714/blood-flow-restricted-exercise-providing-more-bang-for-buck-in-trained-athletes
#20
EDITORIAL
Richard A Ferguson
Blood flow restriction (BFR) has been utilised in physiology for centuries; from William Harvey's (1578-1657) initial use of a tourniquet to describe in detail the systemic circulation of blood, to the use in the last 40 years in the investigation of cardiovascular reflex responses, angiogenesis, skeletal muscle metabolism and fatigue. Recent investigation has largely focussed on the adaptive potential of BFR exercise training, with particular reference to skeletal muscle strength and hypertrophy and its use in the rehabilitation process...
March 25, 2018: Acta Physiologica
keyword
keyword
33726
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"