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Skeletal muscle blood flow

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https://www.readbyqxmd.com/read/28729387/leg-blood-flow-is-impaired-during-small-muscle-mass-exercise-in-copd-patients
#1
Ulrik Winning Iepsen, Gregers Druedal Wibe Munch, Mette Rugbjerg, Camilla Koch Ryrsø, Niels Secher, Ylva Hellsten, Peter Lange, Bente Klarlund Pedersen, Pia Thaning, Stefan P Mortensen
Skeletal muscle blood flow is regulated to match the oxygen demand and dysregulation could contribute to exercise intolerance in patients with COPD. We measured leg hemodynamics and metabolites from vasoactive compounds in muscle interstitial fluid and plasma at rest, during one-legged knee-extensor exercise, and during arterial infusions of sodium nitroprusside (SNP) and acetylcholine (ACh), respectively. Ten patients with moderate to severe COPD and eight age- and sex matched healthy controls were studied...
July 20, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28728939/autonomic-dysreflexia-somatosympathetic-and-viscerosympathetic-vasoconstrictor-responses-to-innocuous-and-noxious-sensory-stimulation-below-lesion-in-human-spinal-cord-injury
#2
Rachael Brown, Alexander R Burton, Vaughan G Macefield
Autonomic dysreflexia is a dangerous elevation in blood pressure in people with spinal cord injury (SCI), produced by a spinally-mediated reflex activation of sympathetic vasoconstrictor neurones supplying skeletal muscle and the gut. Current dogma states that, apart from visceral inputs - such as those originating from a distended bladder or impacted colon - autonomic dysreflexia is triggered by noxious inputs below the lesion. However, while selective stimulation of small-diameter afferents in muscle or skin evokes a sustained increase in muscle sympathetic nerve activity and blood pressure, and a transient increase in skin sympathetic nerve activity and decrease in skin blood flow in able-bodied subjects, such noxious inputs have no effects on blood pressure and skin blood flow in SCI individuals...
July 13, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28721030/regular-physical-exercise-improves-cardiac-autonomic-and-muscle-vasodilatory-responses-to-isometric-exercise-in-healthy-elderly
#3
Adriana de Oliveira Sarmento, Amilton da Cruz Santos, Ivani Credidio Trombetta, Marciano Moacir Dantas, Ana Cristina Oliveira Marques, Leone Severino do Nascimento, Bruno Teixeira Barbosa, Marcelo Rodrigues Dos Santos, Maria do Amparo Andrade, Anna Myrna Jaguaribe-Lima, Maria do Socorro Brasileiro-Santos
The objective of this study was to evaluate cardiac autonomic control and muscle vasodilation response during isometric exercise in sedentary and physically active older adults. Twenty healthy participants, 10 sedentary and 10 physically active older adults, were evaluated and paired by gender, age, and body mass index. Sympathetic and parasympathetic cardiac activity (spectral and symbolic heart rate analysis) and muscle blood flow (venous occlusion plethysmography) were measured for 10 minutes at rest (baseline) and during 3 minutes of isometric handgrip exercise at 30% of the maximum voluntary contraction (sympathetic excitatory maneuver)...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28704614/carbon-dioxide-water-bath-treatment-augments-peripheral-blood-flow-through-the-development-of-angiogenesis
#4
Yan-Jun Xu, Vijayan Elimban, Naranjan S Dhalla
In this study, we investigated the effects of CO2 water-bath therapy on blood flow and angiogenesis in the ischemic hind limb as well as some plasma angiogenic factors in peripheral ischemic model. The hind limb ischemia was induced by occluding the femoral artery for 2 weeks in rats and treated with or without CO2 water-bath therapy at 37°C for 4 weeks (20 min treatment everyday for 5 days per week). The peak blood flow as well as minimal and mean blood flow in the ischemic skeletal muscle were markedly increased by the CO2 water-bath therapy...
July 13, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28687542/skeletal-muscle-microvascular-linked-improvements-in-glycemic-control-from-resistance-training-in-individuals-with-type-2-diabetes
#5
Ryan D Russell, Donghua Hu, Timothy Greenaway, Sarah J Blackwood, Renee M Dwyer, James E Sharman, Graeme Jones, Kathryn A Squibb, Aascha A Brown, Petr Otahal, Meg Boman, Hayder Al-Aubaidy, Dino Premilovac, Christian K Roberts, Samuel Hitchins, Stephen M Richards, Stephen Rattigan, Michelle A Keske
OBJECTIVE: Insulin increases glucose disposal in part by enhancing microvascular blood flow (MBF) and substrate delivery to myocytes. Insulin's microvascular action is impaired with insulin resistance and type 2 diabetes. Resistance training (RT) improves glycemic control and insulin sensitivity, but whether this improvement is linked to augmented skeletal muscle microvascular responses in type 2 diabetes is unknown. RESEARCH DESIGN AND METHODS: Seventeen (11 male and 6 female; 52 ± 2 years old) sedentary patients with type 2 diabetes underwent 6 weeks of whole-body RT...
July 7, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28685423/dorsiflexor-muscle-oxygenation-during-low-moderate-and-submaximal-sustained-isometric-contraction
#6
Adkham Paiziev, Martin Wolf, Fikrat Kerimov
Sustained isometric contractions of skeletal muscles produce intramuscular pressures that lead to blood flow restriction. Thus, we have the paradox of rising O2 demand due to muscle activity and at the same time reduced blood flow. The aim was to assess muscle oxygenation during sustained isometric low (30%), moderate (60%) and submaximal [90% of maximal voluntary contraction (MVC)] contraction of the dorsiflexor muscle. Experiments were conducted on the dominant (right) leg of 8 male students (age 19 ± 2 years, weight 75 ± 6 kg)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28676489/voltage-dependent-ca-2-entry-into-smooth-muscle-during-contraction-promotes-endothelium-mediated-feedback-vasodilation-in-arterioles
#7
Christopher J Garland, Pooneh Bagher, Chloe Powell, Xi Ye, Hamish A L Lemmey, Lyudmyla Borysova, Kim A Dora
Vascular smooth muscle contraction is suppressed by feedback dilation mediated by the endothelium. In skeletal muscle arterioles, this feedback can be activated by Ca(2+) signals passing from smooth muscle through gap junctions to endothelial cells, which protrude through holes in the internal elastic lamina to make contact with vascular smooth muscle cells. Although hypothetically either Ca(2+) or inositol trisphosphate (IP3) may provide the intercellular signal, it is generally thought that IP3 diffusion is responsible...
July 4, 2017: Science Signaling
https://www.readbyqxmd.com/read/28667051/folic-acid-ingestion-improves-skeletal-muscle-blood-flow-during-graded-handgrip-and-plantar-flexion-exercise-in-aged-humans
#8
Steven A Romero, Daniel Gagnon, Amy N Adams, Gilbert Moralez, Ken Kouda, Manall F Jaffery, Matthew N Cramer, Craig G Crandall
Skeletal muscle blood flow is attenuated in aged humans performing dynamic exercise, which is due, in part, to impaired local vasodilatory mechanisms. Recent evidence suggests that folic acid improves cutaneous vasodilation during localized and whole-body heating through nitric oxide-dependent mechanisms. However, it is unclear if folic acid improves vasodilation in other vascular beds during conditions of increased metabolism (i.e. exercise). The purpose of this study was to test the hypothesis that folic acid ingestion improves skeletal muscle blood flow in aged adults performing graded handgrip and plantar flexion exercise via increased vascular conductance...
June 30, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28664576/exercise-versus-vasodilator-stress-limb-perfusion-imaging-for-the-assessment-of-peripheral-artery-disease
#9
Brian P Davidson, J Todd Belcik, Gregory Landry, Joel Linden, Jonathan R Lindner
PURPOSE: Our aim was to determine whether pharmacologic vasodilation is an alternative to exercise stress during limb perfusion imaging for peripheral artery disease (PAD). METHODS: Quantitative contrast-enhanced ultrasound (CEU) perfusion imaging of the bilateral anterior thigh and calf was performed in nine control subjects and nine patients with moderate to severe PAD at rest and during vasodilator stress with dipyridamole. For those who were able, CEU of the calf was then performed during modest plantar flexion exercise (20 watts)...
June 29, 2017: Echocardiography
https://www.readbyqxmd.com/read/28661427/deletion-of-txnip-mitigates-high-fat-diet-impaired-angiogenesis-and-prevents-inflammation-in-a-mouse-model-of-critical-limb-ischemia
#10
Sally L Elshaer, Islam N Mohamed, Maha Coucha, Sara Altantawi, Wael Eldahshan, Megan L Bartasi, Ahmed Y Shanab, Renee Lorys, Azza B El-Remessy
BACKGROUND: Previous work demonstrated that high-fat diet (HFD) triggered thioredoxin-interacting protein (TXNIP) and that silencing TXNIP prevents diabetes-impaired vascular recovery. Here, we examine the impact of genetic deletion of TXNIP on HFD-impaired vascular recovery using hind limb ischemia model. METHODS: Wild type mice (WT, C57Bl/6) and TXNIP knockout mice (TKO) were fed either normal chow diet (WT-ND and TKO-ND) or 60% high-fat diet (WT-HFD and TKO-HFD)...
June 29, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28655467/determination-of-skeletal-muscle-microvascular-flowmotion-with-contrast-enhanced-ultrasound
#11
Sarah J Blackwood, Renee M Dwyer, Eloise A Bradley, Michelle A Keske, Stephen M Richards, Stephen Rattigan
Most methods of assessing flowmotion (rhythmic oscillation of blood flow through tissue) are limited to small sections of tissue and are invasive in tissues other than skin. To overcome these limitations, we adapted the contrast-enhanced ultrasound (CEUS) technique to assess microvascular flowmotion throughout a large region of tissue, in a non-invasive manner and in real time. Skeletal muscle flowmotion was assessed in anaesthetised Sprague Dawley rats, using CEUS and laser Doppler flowmetry (LDF) for comparison...
June 24, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28637396/modulation-of-mir29a-improves-impaired-post-ischemic-angiogenesis-in-hyperglycemia
#12
Lingdan Chen, Emmanuel Okeke, Dawit Ayalew, Danny Wang, Lyeba Shahid, Ayotunde O Dokun
Individuals with diabetes mellitus suffer from impaired angiogenesis and this contributes to poorer peripheral arterial disease outcomes. In experimental peripheral arterial disease, angiogenesis and perfusion recovery are impaired in mice with diabetes. We recently showed that a disintegrin and metalloproteinase domain-containing protein 12 (ADAM12) is upregulated in ischemic endothelial cells and plays a key role in post-ischemic angiogenesis and perfusion recovery following experimental peripheral arterial disease...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28624852/vasoconstrictor-responsiveness-in-contracting-human-muscle-influence-of-contraction-frequency-contractile-work-and-metabolic-rate
#13
Nicholas T Kruse, William E Hughes, Kenichi Ueda, Darren P Casey
PURPOSE: The aim of this study was to examine whether independent effects exist between contractile work and metabolic demand (VO2m) on vasoconstrictor responsiveness (i.e., functional sympatholysis) under different contraction durations matched for total contractile work in exercising human skeletal muscle. METHODS: Ten young men performed rhythmic forearm contractions at 10 and 15% of maximum voluntary contraction (MVC) which consisted of muscle contractions using the same duty cycle but altering the duration of the contraction-relaxation cycles of exercise and included: 1) fast frequency contractions at 10% MVC (FFC10%) using a contraction relaxation cycle at 1:2 s; 2) slow frequency contractions at 10% MVC (SFC10%) at 2:4 s; and 3) SFC at 15% MVC (SFC15%) at 2:4 s...
August 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28590933/the-caudal-pedunculopontine-tegmental-nucleus-may-be-involved-in-the-regulation-of-skeletal-muscle-activity-by-melanocortinsympathetic-pathway-a-virally-mediated-trans-synaptic-tracing-study-in-spinally-transected-transgenic-mice
#14
Zhi-Gang He, Bao-Wen Liu, Zhi-Xiao Li, Xue-Bi Tian, San-Guang Liu, Anne Manyande, Ding-Yu Zhang, Hong-Bing Xiang
Understanding neuroanatomical sympathetic circuitry and neuronal connections from the caudal pedunculopontine tegmental nucleus to skeletal muscle is important to the study of possible mechanisms of pedunculopontine tegmental nucleus (PPTg) and cuneiform nucleus (CnF) that are involved in the regulation of skeletal muscle activity of the sympathetic pathway. The aim of this study was to use virus PRV-614 to trace the melanocortin-sympathetic neural pathways from PPTg and CnF to a hindlimb muscle (gastrocnemius) in spinally transected MC4R-GFP transgenic mice...
May 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28571935/dissociation-of-local-and-global-skeletal-muscle-oxygen-transport-metrics-in-type-2-diabetes
#15
P Mason McClatchey, Timothy A Bauer, Judith G Regensteiner, Irene E Schauer, Amy G Huebschmann, Jane E B Reusch
AIMS: Exercise capacity is impaired in type 2 diabetes, and this impairment predicts excess morbidity and mortality. This defect appears to involve excess skeletal muscle deoxygenation, but the underlying mechanisms remain unclear. We hypothesized that reduced blood flow, reduced local recruitment of blood volume/hematocrit, or both contribute to excess skeletal muscle deoxygenation in type 2 diabetes. METHODS: In patients with (n=23) and without (n=18) type 2 diabetes, we recorded maximal reactive hyperemic leg blood flow, peak oxygen utilization during cycling ergometer exercise (VO2peak), and near-infrared spectroscopy-derived measures of exercise-induced changes in skeletal muscle oxygenation and blood volume/hematocrit...
May 14, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28538308/effect-of-electrical-myostimulation-on-the-function-of-lower-leg-muscles
#16
Viktoras Silinskas, Albinas GrŪnovas, Jurate Stanislovaitiene, Alfonsas Buliuolis, Eugenijus Trinkunas, Jonas Poderys
Electrical myostimulation (EMS) method is applied to improve skeletal muscle function. The aim of this study was to evaluate the efficacy of EMS applied to the sole and calf muscles on their strength and on maximal sprint performance. Each of 10 training sessions involved 10 seconds of stimulation and 50 seconds of rest for a total of 10 minutes. After the 10 training sessions, the maximal voluntary contraction (MVC) of right calf muscles increased by 6.0% from 830.0 ± 47.0 N to 878.0 ± 45.3 N (p ≤ 0.05)...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28533261/the-superoxide-dismutase-mimetic-tempol-does-not-alleviate-glucocorticoid-mediated-rarefaction-of-rat-skeletal-muscle-capillaries
#17
Erin R Mandel, Emily C Dunford, Ghoncheh Abdifarkosh, Patrick C Turnbull, Christopher G R Perry, Michael C Riddell, Tara L Haas
Sustained elevations in circulating glucocorticoids elicit reductions in skeletal muscle microvascular content, but little is known of the underlying mechanisms. We hypothesized that glucocorticoid-induced oxidative stress contributes to this phenomenon. In rats that were implanted with corticosterone (CORT) or control pellets, CORT caused a significant decrease in muscle glutathione levels and a corresponding increase in protein carbonylation, an irreversible oxidative modification of proteins. Decreased endothelial nitric oxide synthase and increased endothelin-1 mRNA levels were detected after 9 days of CORT, and blood flow to glycolytic muscles was diminished...
May 2017: Physiological Reports
https://www.readbyqxmd.com/read/28522759/effect-of-cyclooxygenase-inhibition-on-the-inspiratory-muscle-metaboreflex-induced-cardiovascular-consequences-in-men
#18
Joshua R Smith, Kaylin D Didier, Shane M Hammer, Andrew M Alexander, Stephanie P Kurti, Steven W Copp, Thomas J Barstow, Craig A Harms
Inspiratory muscle metaboreflex activation increases mean arterial pressure (MAP) and limb vascular resistance (LVR) and decreases limb blood flow (Q̇L). Cyclooxygenase (COX) inhibition has been found to attenuate limb skeletal muscle metaboreflex-induced increases in muscle sympathetic nerve activity. We hypothesized that compared to placebo (PLA), COX inhibition would attenuate inspiratory muscle metaboreflex-induced 1) increases in MAP and LVR and 2) decreases in Q̇L Seven men (22±1 years) were recruited and orally consumed ibuprofen (IB, 10mg/kg) or PLA 90 min prior to performing the cold pressor test (CPT) for 2 min and inspiratory resistive breathing task (IRBT) for 14...
May 18, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28513326/the-effects-of-blood-flow-restricted-electrostimulation-on-strength-hypertrophy
#19
Joshua Slysz, Jamie F Burr
CONTEXT: The combined effect of neuromuscular electrical muscle stimulation (NMES) and blood flow restriction (BFR) on muscle mass and strength has not been thoroughly investigated. OBJECTIVE: To examine the effects of combined and independent BFR and a low-intensity NMES on skeletal muscle adaptation. DESIGN: Exploratory Study. SETTING: Laboratory. PARTICIPANTS: Twenty recreationally active subjects...
May 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28502541/prolonged-stance-phase-during-walking-in-intermittent-claudication
#20
Lindy N M Gommans, Annemieke T Smid, Marc R M Scheltinga, Ernst Cancrinus, Frans A M Brooijmans, Kenneth Meijer, Joep A W Teijink
BACKGROUND: Patients with intermittent claudication (IC) tend to walk slower and consume approximately 40% more oxygen during walking compared with healthy individuals. An unfavorable locomotion pattern has been suggested to explain this metabolic inefficiency. However, detailed knowledge of gait parameters in IC is lacking. METHODS: In a cross-sectional study, the gait pattern of newly diagnosed IC patients was compared with that of healthy controls. Spatiotemporal gait parameters such as step length and duration of stance phase were obtained by a photoelectric technique (OptoGait; Microgate, Bolzano, Italy)...
May 11, 2017: Journal of Vascular Surgery
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