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https://www.readbyqxmd.com/read/28807157/antiinflammatory-and-hepatoprotective-medicinal-herbs-as-potential-substitutes-for-bear-bile
#1
Sandra Appiah, Mike Revitt, Huw Jones, Milan Vu, Monique Simmonds, Celia Bell
Practitioners of traditional Chinese medicine (TCM) commonly prescribe medicinal formulations relying on the purported synergism of a combination of plant species, sometimes incorporating animal parts and minerals. Bear bile, obtained from either wild or farmed bears, is a commonly used constituent of traditional medicine formulations. With several bear species now listed under Convention on International Trade in Endangered Species of Wild Fauna and Flora as threatened with extinction and with bear farming being actively campaigned against on ethical grounds, it is important to seek and promote alternatives to the use of bear bile as medicine...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28803999/growth-arrest-and-morphological-changes-triggered-by-emodin-on-trypanosoma-cruzi-epimastigotes-cultivated-in-axenic-medium
#2
Ana R De Lima, Karem Noris-Suárez, Antonio Bretaña, Victor T Contreras, Maria C Navarro, Luis Pérez-Ybarra, José Bubis
Emodin is an anthraquinone obtained from Rheum palmatum rootstocks. Here we tested the cytotoxic effects of emodin on Trypanosoma cruzi epimastigotes, as well as the morphological changes that were induced by this compound in the parasite. Emodin was permeable and blocked in vitro cell division of T. cruzi epimastigotes in axenic medium, causing growth arrest in a dose-dependent but reversible manner. Emodin-exposed epimastigotes underwent duplication of organelles, such as the nucleus, kinetoplast and flagellum, but were incapable of completing cytokinesis...
August 10, 2017: Biochimie
https://www.readbyqxmd.com/read/28798802/prescribed-renoprotective-chinese-herbal-medicines-were-associated-with-a-lower-risk-of-all-cause-and-disease-specific-mortality-among-patients-with-chronic-kidney-disease-a-population-based-follow-up-study-in-taiwan
#3
Chuan-Fa Hsieh, Huan-Cheng Chang, Song-Lih Huang, Chien-Lung Chen, Wei-Ta Chen, Chen-Chang Yang
Chinese herbal medicines (CHMs) containing aristolochic acid (AA) are associated with chronic kidney disease (CKD), but some prescribed CHMs have been shown to possess renoprotective effects. We conducted a nationwide retrospective cohort study to delineate the role of prescribed CHMs on the CKD progression. Renoprotective CHM (RPCHM) was defined if a CHM contained dong chong xia cao (Cordyceps sinensis (Berk.) Sacc.), da huang (Rheum palmatum L), huang qi (Astragalus membranaceus), dan shen (Salvia miltiorrhiza Bge...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28782194/the-preparation-of-hyaluronic-acid-nanoparticles-from-aspicilia-lichens-using-bifido-bacteria-for-help-in-the-treatment-of-diabetes-in-rats-in-vivo
#4
Akbar Esmaeili, Shirin Rajaee
Many common herbs and spices are claimed to have blood sugar lowering properties that make them useful for people with or at high risk of diabetes. The main of compounds of kiwifruit (Actinidia deliciosa), rhubarb (Rheum ribes), membrane inner of egg shell, wool of sheep, human fingernail (unguis), hyaluronic acid produced by the Bifidobacterium, and usnic acid of Aspicilia lichen were extracted by different methods. All compounds of the extract were divided into five groups. We used variables such as pH, different compounds, concentration, number of injections, and blood glucose monitoring in different situations...
August 7, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28730954/evaluation-of-in-vitro-anti-psoriatic-activity-of-a-novel-polyherbal-formulation-by-multiparametric-analysis
#5
Nadav Shraibom, Alka Madaan, Vidushi Joshi, Ritu Verma, Anika Chaudhary, Gautam Mishra, Anshumali Awasthi, Anu Taneja Singh, Manu Jaggi
The beneficial role of traditional herbal medicines in the treatment of inflammatory skin disorders has been widely reported. Psoriasis is characterized by uncontrolled hyper-proliferation of keratinocytes, disturbed apoptosis, over-secretion of inflammatory cytokines and angiogenic factors. We have developed a novel aqueous polyherbal formulation (SIRB-001) consisting of 3 herbs; Rheum palmatum L., Rehmannia glutinosa Libosch and Lonicera Japonica in the ratio 1:1:3. SIRB-001 has demonstrated efficacious effects in psoriasis patients...
July 20, 2017: Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28713834/renoprotective-effect-of-the-shen-yan-fang-shuai-formula-by-inhibiting-tnf-%C3%AE-nf-%C3%AE%C2%BAb-signaling-pathway-in-diabetic-rats
#6
Jie Lv, Zhen Wang, Ying Wang, Weiwei Sun, Jingwei Zhou, Mengdi Wang, Wei Jing Liu, Yaoxian Wang
Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease, and satisfactory therapeutic strategies have not yet been established. The Shen-Yan-Fang-Shuai Formula (SYFSF) is a traditional Chinese formula composed of Astragali radix, Radixangelicae sinensis, Rheum officinale Baill, and four other herbs. It has been widely used as an effective treatment for DKD patients in China. However, little is known about the molecular mechanisms underlying SYFSF's renoprotection. In this study, we compared the protective effect of SYFSF to irbesartan on the histology and renal cells in type 2 DKD rat model and high-glucose (HG) cultured mesangial cells, respectively...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28703078/chrysophanol-suppresses-pro-inflammatory-response-in-microglia-via-regulation-of-drp1-dependent-mitochondrial-fission
#7
Unbin Chae, Ju-Sik Min, Hanna Lee, Kyung-Sik Song, Hyun-Shik Lee, Hong Jun Lee, Sang-Rae Lee, Dong-Seok Lee
OBJECTIVES: Chrysophanol, also called chrysophanic acid, is a natural anthraquinone compound found in Rheum palmatum. R. palmatum has been used in oriental medicine in ancient East Asia. Microglial cells represent not only the forefront immune defense in the central nervous system but also the most reactive sensors to various threats. However, activated microglia can exert neurotoxic effects via excessive production of cytotoxic molecules and proinflammatory cytokines. Therefore, modulation of microglial cell activation is important for maintaining neuronal function...
July 13, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28678381/antimetastatic-effects-of-rheum-palmatum-l-extract-on-oral-cancer-cells
#8
Yang-Yu Chen, Ming-Ju Hsieh, Yih-Shou Hsieh, Yu-Chao Chang, Pei-Ni Chen, Shun-Fa Yang, Hsin-Yu Ho, Ying-Erh Chou, Chiao-Wen Lin
Rheum palmatum L., a traditional Chinese medication, has been used for the treatment of various disorders. However, the detailed impacts and underlying mechanisms of R. palmatum L. extracts (RLEs) on human oral cancer cell metastasis are still unclear. Here, we tested the hypothesis that an RLE has antimetastatic effects on SCC-9 and SAS human oral cancer cells. Gelatin zymography, Western blot, real-time polymerase chain reaction, and luciferase assay were used to explore the underlying mechanisms involved in the antimetastatic effects on oral cancer cells...
July 5, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28676176/corrigendum-to-systematic-review-of-systemic-sclerosis-specific-instruments-for-the-eular-outcome-measures-library-an-evolutional-database-model-of-validated-patient-reported-outcomes-semin-arthritis-rheum-46-5-2017-609-614
#9
Francesca Ingegnoli, Loreto Carmona, Isabel Castrejon
No abstract text is available yet for this article.
July 1, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28668805/-rheum-to-improve-quality-improvement-in-outpatient-rheumatology
#10
Shirley L Chow, Kaveh G Shojania
The commitment to improve care processes and patient outcomes is a professional mandate for clinicians and is also seen as an operational priority for institutions. Quality improvement now figures in the accreditation of training programs, specialty examinations, and hospital scorecards. Rheumatologists have traditionally focused primarily on quality problems such as guideline adherence; however, improvement goals should also include other aspects of care that are helpful to patients and are professionally rewarding for practitioners...
July 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28641287/chrysophanol-suppressed-glutamate-induced-hippocampal-neuronal-cell-death-via-regulation-of-dynamin-related-protein-1-dependent-mitochondrial-fission
#11
Unbin Chae, Ju-Sik Min, Hyun Hee Leem, Hyun-Shik Lee, Hong Jun Lee, Sang-Rae Lee, Dong-Seok Lee
Chrysophanic acid, or chrysophanol, is an anthraquinone found in Rheum palmatum, which was used in the preparation of oriental medicine in ancient China. The hippocampus plays a major role in controlling the activities of the short- and long-term memory. It is one of the major regions affected by excessive cell death in Alzheimer's disease. Therefore, neuronal cell-death modulation in the hippocampus is important for maintaining neuronal function. We investigated chrysophanol's effects on glutamate-induced hippocampal neuronal cell death...
2017: Pharmacology
https://www.readbyqxmd.com/read/28618413/induction-of-apoptosis-in-heparg-cell-line-by-aloe-emodin-through-generation-of-reactive-oxygen-species-and-the-mitochondrial-pathway
#12
Xiaoxv Dong, Jing Fu, Xingbin Yin, Changhai Qu, Chunjing Yang, Huyiligeqi He, Jian Ni
BACKGROUND/AIMS: Aloe-emodin (1,8-dihydroxy-3-hydroxymethyl-anthraquinone), an anthraquinone active compounds, is isolated from some traditional medicinal plants such as Rheum palmatum L. and Cassia occidentalis, which induce hepatotoxicity in rats. The aim of this study was to determine potential cytotoxic effects of aloe-emodin on HepaRG cells and to define the underlying mechanism. METHODS: MTT was used to evaluate cell viability. Apoptotic cell death was analyzed via Annexin V-FITC/PI double staining...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28616631/the-effect-of-emodin-on-staphylococcus-aureus-strains-in-planktonic-form-and-biofilm-formation-in-vitro
#13
Xin Yan, Shanshan Gu, Yunjia Shi, Xingyang Cui, Shanshan Wen, Junwei Ge
Staphylococcus aureus (S. aureus) is a Gram-positive pathogen and forms biofilm easily. Bacteria inside biofilms display an increased resistance to antibiotics and disinfectants. The objective of the current study was to assess the antimicrobial activities of emodin, 1,2,8-trihydroxy-6-methylanthraquinone, an anthraquinone derivative isolated from Polygonum cuspidatum and Rheum palmatum, against S. aureus CMCC26003 grown in planktonic and biofilm cultures in vitro. In addition, a possible synergistic effect between emodin and berberine chloride was evaluated...
June 14, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28602867/effect-of-gangjihwan-on-hepatic-steatosis-and-inflammation-in-high-fat-diet-fed-mice
#14
Jong Seong Roh, Haerim Lee, Jonghoon Lim, Jeongjun Kim, Heejung Yang, Yooshik Yoon, Soon Shik Shin, Michung Yoon
ETHNOPHARMACOLOGICAL RELEVANCE: Gangjihwan (DF), a polyherbal drug composed of Ephedra intermedia Schrenk et C. A. Mayer (Ephedraceae), Lithospermum erythrorhizon Siebold et Zuccarini (Borraginaceae), and Rheum palmatum L. (Polygonaceae), is used to treat obesity in local Korean clinics. The constituents of DF have traditionally been reported to exert anti-obesity and anti-nonalcoholic fatty liver disease (NAFLD) effects. Thus, we investigated the effects of DF on obesity and NAFLD and the underlying mechanisms...
July 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28573250/the-use-of-rheum-palmatum-l-in-the-treatment-of-acute-respiratory-distress-syndrome-a-meta-analysis-of-randomized-controlled-trials
#15
Tie-Zhu Yang, Yan Liu, Yue-Yun Liu, Xiu-Fang Ding, Jia-Xu Chen, Mei-Jing Kou, Xiao-Juan Zou
BACKGROUND: Chinese medicine theory shows that "lung being connected with large intestine", and the modern western medicine also shows that the lung and intestinal tract affect each other in physiological and pathological conditions. If the lung ventilation dysfunction is caused by inflammatory exudate or secretions obstruction of the small airway ventilation, blood gas partial pressure is increased and intestinal gas absorption difficulty may lead to intestinal inflation and dysfunction (Wang N et al...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28569293/rhubarb-rheum-species-the-role-of-edinburgh-in-its-cultivation-and-development
#16
M R Lee, J Hutcheon, E Dukan, I Milne
Rhubarb was grown and used throughout China for thousands of years. It then found its way to St Petersburg where the Romanovs developed a flourishing trade in the plant to the rest of Europe. James Mounsey, a physician to the Tsar, brought back seeds from Russia to Scotland at considerable risk to himself. He passed some of the seeds to Alexander Dick and John Hope. Both these physicians then grew rhubarb at Prestonfield and the Botanic Garden (both in Edinburgh), respectively. Eventually rhubarb, in the form of Gregory's powder, became a common and popular medicine throughout the UK...
March 2017: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/28507818/screening-of-a-natural-compound-library-identifies-emodin-a-natural-compound-from-rheum-palmatum-linn-that-inhibits-dpp4
#17
Zhaokai Wang, Longhe Yang, Hu Fan, Peng Wu, Fang Zhang, Chao Zhang, Wenjie Liu, Min Li
Historically, Chinese herbal medicines have been widely used in the treatment of hyperglycemia, but the mechanisms underlying their effectiveness remain largely unknown. Here, we screened a compound library primarily comprised of natural compounds extracted from herbs and marine organisms. The results showed that emodin, a natural compound from Rheum palmatum Linn, inhibited DPP4 activity with an in vitro IC50 of 5.76 µM without inhibiting either DPP8 or DPP9. A docking model revealed that emodin binds to DPP4 protein through Glu205 and Glu206, although with low affinity...
2017: PeerJ
https://www.readbyqxmd.com/read/28485221/web-review-your-rheum
#18
Simon Stones
Social media sites that encourage peer support among young people with rheumatic conditions.
May 9, 2017: Nursing Children and Young People
https://www.readbyqxmd.com/read/28475921/pharmacokinetics-and-pharmacodynamics-of-rhubarb-anthraquinones-extract-in-normal-and-disease-rats
#19
Peijin Li, Qianfeng Lu, Wenjiao Jiang, Xue Pei, Yilin Sun, Haiping Hao, Kun Hao
BACKGROUND: Anthraquinones extract from Rheum palmatum L. (rhubarb) including rhein, emodin, aloe-emodin, chrysophanol, physcion and sennoside A, has been widely used in China to treat various diseases. OBJECTIVE: This study was designed to explore the pharmacokinetic and pharmacodynamic properties of rhubarb anthraquinones extract in diabetic nephropathy and acute liver injury rats. METHODS: The diabetic nephropathy and acute liver injury rats were induced by intraperitoneal injection with streptozotocin (STZ) and carbon tetrachloride (CCL4), respectively...
July 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28444790/aloe-emodin-induces-apoptosis-in-human-liver-hl-7702-cells-through-fas-death-pathway-and-the-mitochondrial-pathway-by-generating-reactive-oxygen-species
#20
Xiaoxv Dong, Jing Fu, Xingbin Yin, Chunjing Yang, Jian Ni
Aloe-emodin (1,8-dihydroxy-3-hydroxymethyl-anthraquinone) is one of the primary active compounds in total rhubarb anthraquinones isolated from some traditional medicinal plants such as Rheum palmatum L. and Cassia occidentalis, which induce hepatotoxicity in rats. Thus, the aim of this study was to determine the potential cytotoxic effects and the underlying mechanism of aloe-emodin on human normal liver HL-7702 cells. The CCK-8 assays demonstrated that aloe-emodin decreased the viability of HL-7702 cells in a dose-dependent and time-dependent manner...
June 2017: Phytotherapy Research: PTR
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