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JOURNAL ARTICLE
Zi-Wei Duan, Yong Liu, Pei-Pei Zhang, Jing-Yan Hu, Zhi-Xin Mo, Wen-Qing Liu, Xin Ma, Xiao-Hui Zhou, Xiao-Hui Wang, Xiu-Hua Hu, Sheng-Li Wei
ETHNOPHARMACOLOGICAL RELEVANCE: Da-Chai-Hu-Tang (DCHT), a Chinese traditional herbal compound, has been utilized for the treatment of Hepatic diseases in China for over 1,800 years. The DCHT formula contains eight herbals: Bupleurum chinense DC. (chaihu), Scutellaria baicalensis Georgi (huangqin), Paeonia lactiflora Pall. (baishao), Pinellia ternata (Thunb.) Makino (banxia), Rheum officinale Baill. (dahuang), Citrus × aurantium L. (zhishi), Zingiber officinale Roscoe (shengjiang), Ziziphus jujuba Mill...
May 3, 2024: Journal of Ethnopharmacology
#2
JOURNAL ARTICLE
Lixia Dai, Xiaolou Miao, Yudong Ma, Xiaorong Yang, Bing Li, Jian He, Yu Wang, Pengcheng Dong, Jiyu Zhang, Xiaofei Shang
Rhubarb contains an abundance of compounds and nutrients that promote health through various activities; however, these activities are affected by the harvest season. In this paper, the changes in nutrients, phytochemical profiles and antioxidant activity of Rheum officinale leaf blades (LRO) during different growth periods were investigated. The results showed that LRO is a good source of protein, fiber, and minerals and contains abundant fatty acids; however, as the harvest time increased from March to July, the levels of protein and amino acid decreased, and the levels of other nutrients reached a maximum in May or June...
2024: Frontiers in Nutrition
#3
JOURNAL ARTICLE
Tianyi Ren, Hui Feng, Yong Xu, Yun Ling
ETHNOPHARMACOLOGICAL RELEVANCE: Dahuang Huanglian Xiexin Decoction (XXD), derived from Zhang Zhongjing's Treatise on Typhoid Fever, has a long history of medicinal use and is widely used for digestive system diseases. It is mainly composed of three natural medicines, including Dahuang (Rheum palmatum L.), Huanglian (Coptis chinensis Franch.), and Huangqin (Scutellaria baicalensis Georgi). Modern pharmacological research shows that the active ingredients of XXD can have a positive effect on intestinal flora regulatory effect, but its mechanism of action is unclear...
April 28, 2024: Journal of Ethnopharmacology
#4
JOURNAL ARTICLE
Lixia Dai, Xinyuan Cao, Xiaolou Miao, Xiaorong Yang, Jiyu Zhang, Xiaofei Shang
BACKGROUND: Rhubarb is widely distributed and cultivated worldwide, and its leaves presented antioxidant activity and could be used as food additive. However, the chemical ingredients, and protective effect of Rheum officinale leaf juice (JROL) on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) are still unclear. PURPOSE: This paper sought to the characterization and functional properties of JROL, and explore the underlying mechanism on UC mice. METHODS: UPLC-ESI-Q-TOF/MS and other analytical instruments were employed to determine the chemical ingredients of JROL...
April 18, 2024: Phytomedicine
#5
MULTICENTER STUDY
Laura Andreoli, Maria Chiara Gerardi, Maria Gerosa, Davide Rozza, Francesca Crisafulli, Roberta Erra, Daniele Lini, Laura Trespidi, Melissa Padovan, Francesca Ruffilli, Francesca Serale, Giovanna Cuomo, Bernd Raffeiner, Paolo Semeraro, Chiara Tani, Maria Sole Chimenti, Paola Conigliaro, Ariela Hoxha, Cecilia Nalli, Micaela Fredi, Maria Grazia Lazzaroni, Matteo Filippini, Marco Taglietti, Franco Franceschini, Sonia Zatti, Chiara Loardi, Rossana Orabona, Francesca Ramazzotto, Cristina Zanardini, Giulia Fontana, Giorgia Gozzoli, Claudia Barison, Paola Bizioli, Roberto Felice Caporali, Giulia Carrea, Manuela Wally Ossola, Beatrice Maranini, Ettore Silvagni, Marcello Govoni, Danila Morano, Rosita Verteramo, Andrea Doria, Teresa Del Ross, Maria Favaro, Antonia Calligaro, Marta Tonello, Maddalena Larosa, Margherita Zen, Alessandra Zambon, Marta Mosca, Dina Zucchi, Elena Elefante, Sabrina Gori, Florenzo Iannone, Maria Grazia Anelli, Marlea Lavista, Anna Abbruzzese, Carlo Giuseppe Fasano, Salvatore D'Angelo, Maria Stefania Cutro, Valentina Picerno, Teresa Carbone, Angela Anna Padula, Patrizia Rovere-Querini, Valentina Canti, Rebecca De Lorenzo, Ludovica Cavallo, Véronique Ramoni, Carlomaurizio Montecucco, Veronica Codullo, Alessandra Milanesi, Giulia Pazzola, Giuseppina Comitini, Chiara Marvisi, Carlo Salvarani, Oscar Massimiliano Epis, Sara Benedetti, Giuseppina Di Raimondo, Clizia Gagliardi, Claudia Lomater, Gloria Crepaldi, Elisa Bellis, Francesca Bellisai, Estrella Garcia Gonzalez, Anna Paola Pata, Martina Zerbinati, Maria Letizia Urban, Irene Mattioli, Annamaria Iuliano, Giandomenico Sebastiani, Antonio Luca Brucato, Emanuele Bizzi, Maurizio Cutolo, Leonardo Santo, Sara Tonetta, Gianpiero Landolfi, Greta Carrara, Alessandra Bortoluzzi, Carlo Alberto Scirè, Angela Tincani
OBJECTIVES: To investigate pregnancy outcomes in women with autoimmune rheumatic diseases (ARD) in the Italian prospective cohort study P-RHEUM.it. METHODS: Pregnant women with different ARD were enrolled for up to 20 gestational weeks in 29 Rheumatology Centres for 5 years (2018-2023). Maternal and infant information were collected in a web-based database. RESULTS: We analysed 866 pregnancies in 851 patients (systemic lupus erythematosus was the most represented disease, 19...
April 24, 2024: RMD Open
#6
JOURNAL ARTICLE
Vishal P Dubey, Varun P Sureja, Dharmeshkumar B Kheni
Menopause is characterized by various physical, mental and emotional symptoms. ERr 731 ® is a standardized extract from Rheum rhaponticum root and has been clinically studied for its role in reducing menopausal symptoms. The current systematic review and meta-analysis aimed to evaluate the efficacy of ERr 731 ® supplementation in alleviating the severity of menopausal symptoms. In this review, we searched across three online databases up to March 2023, evaluated the quality of the included studies by the Physiotherapy Evidence Database scale, and assessed the risk of bias by the Cochrane Risk of Bias tool...
April 18, 2024: Journal of Biomedical Research
#7
JOURNAL ARTICLE
Haimeng Luoa, Xiaoyun Jia, Mengyu Zhanga, Yaoyao Renb, Rui Tana, Hezhong Jianga, Xiaoqing Wua
Aloe-emodin (AE) is an anthraquinone derivative and a biologically active component sourced from various plants, including Rheum palmatum L. and Aloe vera. Known chemically as 1,8-dihydroxy-3-hydroxymethyl-anthraquinone, AE has a rich history in traditional medicine and is esteemed for its accessibility, safety, affordability, and effectiveness. AE boasts multiple biochemical and pharmacological properties, such as strong antibacterial, antioxidant, and antitumor effects. Despite its array of benefits, AE's identity as an anthraquinone derivative raises concerns about its potential for liver and kidney toxicity...
April 18, 2024: Mini Reviews in Medicinal Chemistry
#8
JOURNAL ARTICLE
Haijiao Shi, Miao Sun, Shuai Wang, Fanyu He, Ronglai Yang, Zheng Li, Wei Chen, Fengrong Wang
ETHNOPHARMACOLOGICAL RELEVANCE: JiaWei DaChaiHu is composed of Bupleurum chinense, Scutellaria baicalensis, Pinellia ternata, Paeonia lactiflora, Zingiber officinale Roscoe, Poncirus tuifoliata, Rheum palmatum L., Curcumae Radix, Herba Lysimachiae, Ziziphus. JiaWei DaChaiHu one of the most common traditional Chinese medicines for the treatment of depression. AIM OF THE STUDY: The chronic unpredictable mild stress (CUMS) has been shown to promote atherosclerosis (AS)...
April 15, 2024: Journal of Ethnopharmacology
#9
JOURNAL ARTICLE
Scott E Wenderfer, Jennifer C Cooper
A 14-year-old patient presents with hematuria and proteinuria. Clinical evaluation reveals a positive anti-nuclear antibody titer, positive anti-double stranded DNA antibody and hypocomplementemia. Systemic lupus erythematosus (SLE) is diagnosed based on the 2019 EULAR/ACR (European League Against Rheumatism/American College of Rheumatology) classification criteria (Aringer et al. Arthritis Rheumatol 71:1400-1412, 2019). A kidney biopsy is performed that confirms the presence of immune complex glomerulonephritis, ISN-RPS (International Society of Nephrology/Renal Pathology Society) class IV (Bajema et al...
April 12, 2024: Pediatric Nephrology
#10
JOURNAL ARTICLE
Tianyi Zhang, Lipan Zhou, Yang Pu, Yadi Tang, Jie Liu, Li Yang, Tao Zhou, Li Feng, Xumei Wang
BACKGROUND: Rhubarb is one of common traditional Chinese medicine with a diverse array of therapeutic efficacies. Despite its widespread use, molecular research into rhubarb remains limited, constraining our comprehension of the geoherbalism. RESULTS: We assembled the genome of Rheum palmatum L., one of the source plants of rhubarb, to elucidate its genome evolution and unpack the biosynthetic pathways of its bioactive compounds using a combination of PacBio HiFi, Oxford Nanopore, Illumina, and Hi-C scaffolding approaches...
April 10, 2024: BMC Plant Biology
#11
JOURNAL ARTICLE
Shiman Luo, Meilan Huang, Xiaohua Lu, Mingming Zhang, Huiling Xiong, Xiyue Tan, Xinyu Deng, Wenwen Zhang, Xiao Ma, Jinhao Zeng, Thomas Efferth
BACKGROUND: Cholestatic hepatitis is recognized as a significant contributor to the development of liver fibrosis and cirrhosis. As a well-known classic formula for the treatment of cholestatic hepatitis, Yinchenhao decoction (YCHD) is widely used in countries in Asia, including China, Japan, and Korea. However, in recent years, a risk of liver injury has been reported from Rheum palmatum L. and Gardenia jasmonoides J.Ellis which are the main ingredients of YCHD. Therefore, the question arises whether YCHD is still safe enough for the treatment of cholestatic hepatitis or whether an optimized ratio of ingredients should be applied...
March 28, 2024: Phytomedicine
#12
JOURNAL ARTICLE
Mid-infrared spectroscopic identification of the right-baked rhubarb for ulcerative colitis therapy.
Jing Sun, Linying Zhong, Ling Dong, Jianbo Chen
Clinical and experimental evidences have confirmed the significant therapeutic effects of rhubarb on ulcerative colitis (UC), but the strong purgative function of rhubarb also aggravates UC symptoms such as bloody diarrhea. Stir-baking to scorch is a traditional Chinese medicinal processing method that can eliminate the adverse purgative function while keep or even enhance the UC therapeutic function of rhubarb. However, the under-baked rhubarb still have the undesirable purgative function, but the over-baked rhubarb may lose the required medicinal functions...
April 2, 2024: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
#13
JOURNAL ARTICLE
Jinsheng Gao, Yousong Li, Jiaohua Chen, Wen Feng, Jianchen Bu, Zixuan Lu, Jiandong Wang
BACKGROUND: Emodin, a natural anthraquinone derivative isolated from the roots of Rheum officinale Baill, has many pharmacological effects including anti-inflammatory, antioxidant, antiviral, antibacterial and anti-cancer. However, little is known about the effect of emodin on acute radiation proctitis (ARP). The present study was conducted to determine its effects and elucidate its mechanisms involving AKT/MAPK/NF-κB/VEGF pathways in ARP mice. METHODS: Total 60 C57BL/6 mice were divided randomly into control group, ARP group, AKT inhibitor MK-2206 group, and different doses of emodin groups...
March 30, 2024: International Immunopharmacology
#14
REVIEW
Chung-Chun Wu, Mei-Shu Chen, Jen-Yang Chen
Nasopharyngeal carcinoma (NPC) is a malignancy prevailing in Taiwan, Hong Kong, Southern China, Southeast Asia, and North Africa. Although early-stage NPC responds well to the primary treatment of radio-chemotherapy, the mortality rate of advanced NPC remains high. Therefore, developing new therapies for nasopharyngeal carcinoma is an urgent task. Emodin is an anthraquinone derivative mainly found in Rheum palmatum . Emodin has been found to possess many anti-cancer functions against various types of cancers, but they are less discussed in the treatment of NPC...
February 21, 2024: Biomedicines
#15
JOURNAL ARTICLE
Lingling Wang, Shuo Zhao, Jianan Li, Guoying Zhou
BACKGROUND: Plant growth and quality are often affected by environmental factors, including geographical location, climate, and soil. In this study, we describe the effect of altitudinal differences on the growth and active ingredients in Rheum tanguticum Maxim. ex Balf. (R. tanguticum), a traditional Chinese medicinal herb known for its laxative properties. RESULTS: The results showed that plants grown at lower altitudes had better growth performances than those in higher altitude areas...
March 28, 2024: BMC Plant Biology
#16
JOURNAL ARTICLE
Xue Xiao, Xiaokang Guan, Zhouyi Xu, Qiao Lu
With its high resolving power and sensitivity, mass spectrometry is considered the most informative technique for metabolite qualitation and quantification in the plant sciences. However, the spatial location information, which is crucial for the exploration of plant physiological mechanisms, is lost. Mass spectrometry imaging (MSI) is able to visualize the spatial distribution of a large number of metabolites from the complex sample surface in a single experiment. In this paper, a flexible and low-cost laser desorption-dielectric barrier discharge ionization-MSI (LD-DBDI-MSI) platform was constructed by combining an LD system with an in-line DBDI source, a high-precision sample translation stage, and an ambient mass spectrometer...
February 21, 2024: Metabolites
#17
JOURNAL ARTICLE
Ke Wang, Hua Qiu, Fang Chen, Pingping Cai, Fanghua Qi
Chronic constipation is one of the most common gastrointestinal disorders worldwide. Due to changes in diet, lifestyle, and the aging population, the incidence of chronic constipation has increased year by year. It has had an impact on daily life and poses a considerable economic burden. Nowadays, many patients with chronic constipation try to seek help from complementary and alternative therapies, and traditional Chinese medicine (TCM) is often their choice. The intestinal flora play an important role in the pathogenesis of constipation by affecting the body's metabolism, secretion, and immunity...
March 25, 2024: Bioscience Trends
#18
JOURNAL ARTICLE
Fan Yang, Xinghua Li, Yujie Zhang, Yun Ren, Jiao Zhang, Keyuan Xiao
The objective of this study was to investigate the potential targets and mechanism of Rheum palmatum L in the treatment of colorectal cancer based on the network pharmacology and molecular docking, which could provide the theoretical basis for clinical applications. The potential components were screened using TCMSP database and articles. The gene targets of colorectal cancer were screened through the Genecards database and Online Mendelian Inheritance in Man database. Then, the common targets of components and colorectal cancer were used to construct the network diagram of active components and targets in Cytoscape 3...
March 22, 2024: Medicine (Baltimore)
#19
JOURNAL ARTICLE
Feriha Göksu, Zeynep Özlü, Sibel Bölek
As a traditional staple food, bread lacks several nutrients such as fiber and minerals. In this study, the possibilities of using rhubarb powder to enrich wheat bread were investigated. Rhubarb powder was replaced with wheat flour at the ratios of 0%, 4%, 8%, and 12%. In order to reveal effects of rhubarb powder on quality properties of bread, color, moisture, total protein, fat content, antioxidant activity, textural, and sensory analysis were conducted. As the rhubarb powder ratio increased, the fiber (10...
March 15, 2024: Journal of Food Science
#20
JOURNAL ARTICLE
Helen Saul, Brendan Deeney, Laura Swaithes, Edward Roddy
The studyRoddy E, Bajpai R, Forrester H, et al. Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink. Ann Rheum Dis 2023;82:1618-25.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/how-common-are-side-effects-of-treatment-to-prevent-gout-flares-when-starting-allopurinol/.
March 8, 2024: BMJ: British Medical Journal
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