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https://www.readbyqxmd.com/read/28031235/htp-nutraceutical-screening-for-histone-deacetylase-inhibitors-and-effects-of-hdacis-on-tumor-suppressing-mirnas-by-trichostatin-a-and-grapeseed-vitis-vinifera-in-hela-cells
#1
Elizabeth A Mazzio, Karam F A Soliman
BACKGROUND/AIM: Aggressive tumor malignancies are a consequence of delayed diagnosis, epigenetic/phenotype changes and chemo-radiation resistance. Histone deacetylases (HDACs) are a major epigenetic regulator of transcriptional repression, which are highly overexpressed in advanced malignancy. While original chemotherapy drugs were modeled after phytochemicals elucidated by botanical screenings, HDAC inhibitors (HDACi) such as apicidin, trichostatin A (TSA) and butyrate were discovered as products of fungus and microbes, in particular, gut microbiota...
2, 2017: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/28027536/effects-of-a-standardized-extract-of-rheum-turkestanicum-janischew-root-on-diabetic-changes-in-the-kidney-liver-and-heart-of-streptozotocin-induced-diabetic-rats
#2
Azar Hosseini, Hamid Mollazadeh, Mohammad Sadegh Amiri, Hamid Reza Sadeghnia, Ahmad Ghorbani
Numerus studies highlighted benefits of natural flavonoids in the management of diabetes. The present study was aimed to investigate the effects of a high flavonoids containing extract of Rheum turkestanicum on diabetic changes in different tissues. Male Wistar rats were divided into normal and streptozotocin-induced diabetic groups received saline or hydroalcoholic extract of R. turkestanicum root (100, 200 and 300mg/kg) through orogastric gavage for 4 weeks. Serum glucose, HbA1c, lipids, creatinine, uric acid, liver enzymes (alkaline phosphatase, aspartate aminotransferase and alanine aminotransferase), and cardiac enzymes (lactate dehydrogenase and creatine phosphokinase) in diabetic control group were significantly higher compared to normal control group (p<0...
December 24, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27976036/lipoxygenase-inhibitory-constituents-from-rheum-undulatum-linn%C3%A3
#3
D H Park, J H Han, Y W Jung, J A Kim, B S Min
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27965575/san-huang-xie-xin-tang-constituents-exert-drug-drug-interaction-of-mutual-reinforcement-at-both-pharmacodynamics-and-pharmacokinetic-level-a-review
#4
REVIEW
Jiasi Wu, Yingfan Hu, Li Xiang, Sheng Li, Yi Yuan, Xiaomei Chen, Yan Zhang, Wenge Huang, Xianli Meng, Ping Wang
Inflammatory disorders underlie varieties of human diseases. San-Huang-Xie-xin-Tang (SHXXT), composed with Rhizoma Rhei (Rheum palmatum L.), Rhizoma Coptidis (Coptis chinensis Franch), and Radix Scutellaria (Scutellaria baicalensis Georgi), is a famous formula which has been widely used in the fight against inflammatory abnormalities. Mutual reinforcement is one of the basic theories of traditional Chinese medicine. Here this article reviewed and analyzed the recent research on (1) How the main constituents of SHXXT impact on inflammation-associated signaling pathway molecules...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27929444/using-light-microscopy-and-liquid-chromatography-tandem-mass-spectrometry-for-qualitative-and-quantitative-control-of-a-combined-three-herb-formulation-in-different-preparations
#5
Tun-Pin Hsueh, Wan-Ling Lin, Tung-Hu Tsai
Artemisia capillaries Thunb, Gardenia jasminoides Ellis, and Rheum officinale Baill have been combined to treat jaundice for thousands of years. Studies have revealed that these herbs induce anti-hepatic fibrosis and anti-hepatic apoptosis and alleviate hepatic oxidative stress. This study aims to determine the quality and quantity of an herbal formulation (Chinese name: Yin-Chen-Hao-Tang) using physical and chemical examinations. Physical examination of Yin-Chen-Hao-Tang in pharmaceutical herbal products, raw fiber powders, and decoction preparations was performed using Congo red and iodine-potassium staining...
December 6, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27891789/incorrect-panel-in-figure-3-of-the-article-by-ellman-et-al-arthritis-rheum-june-2012
#6
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27882165/emodin-inhibits-migration-and-invasion-of-mhcc-97h-human-hepatocellular-carcinoma-cells
#7
Wanfu Lin, Maofeng Zhong, Shufang Liang, Yongan Chen, Dong Liu, Zifei Yin, Qingxin Cao, Chen Wang, Changquan Ling
Emodin, an anthraquinone derivative from the root and rhizome of Rheum palmatum L., was found to have antitumor effects in different types of cancer by regulating multi-molecular targets. The aim of the present study was to explore the effect of emodin on the migration and invasion of MHCC-97H human hepatocellular carcinoma cells and the underlying molecular mechanisms. Firstly, it was demonstrated that emodin can inhibit cell proliferation and induce apoptosis of cells in a time- and dose-dependent manner, using a MTT assay and flow cytometry, respectively...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27812335/rapid-hplc-quantification-approach-for-detection-of-active-constituents-in-modern-combinatorial-formula-san-huang-xie-xin-tang-shxxt
#8
Tung-Ying Wu, Fang-Rong Chang, Jing-Ru Liou, I-Wen Lo, Tang-Chia Chung, Li-Yao Lee, Chun-Chen Chi, Ying-Chi Du, Man-Hon Wong, Suh-Hang Hank Juo, Chun-Chen Lee, Yang-Chang Wu
San-Huang-Xie-Xin-Tang (SHXXT), one of the most important traditional Chinese medicinal formulas, is comprised by three herbal medicines, the rhizome of Rheum officinale [or Rheum tanguticum (Polygonaceae) (Dahuang in Chinese)], the root of Scutellaria baicalensis (Labiatae) (Huangqin in Chinese), and the rhizome of Coptis chinensis (Ranunculaceae) (Huanglian in Chinese) in the ratios of 2:1:1 or 1:1:1. This study is aimed to quantitate and qualify of SHXXT, by a rapid, convenient, and effective HPLC-PDA approach associated with LC-MS technique...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27790424/efficacy-of-aqueous-and-methanolic-extracts-of-rheum-spiciformis-against-pathogenic-bacterial-and-fungal-strains
#9
Khalid Bashir Dar, Aashiq Hussain Bhat, Shajrul Amin, Suhail Anees, Akbar Masood, Mohammed Iqbal Zargar, Showkat Ahmad Ganie
INTRODUCTION: Rheum spiciformis is a newly identified edible medicinal plant of genus Rheum. The plant is used to treat various diseases on traditional levels in Kashmir Valley, India. AIM: To evaluate the phytochemical screening, antibacterial and antifungal potential of aqueous and methanolic extracts of Rheum spiciformis, a traditionally used edible medicinal plant. MATERIALS AND METHODS: Methanolic and aqueous extracts of Rheum spiciformis were tested for their antimicrobial activities against six bacterial strains namely Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus vulgaris and Escherichia coli and four fungal strains Penicillium chrysogenum, Aspergillus fumigatus, Candida albicans and Saccharomyces cerevisiae...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27769031/synthesis-sar-and-pharmacological-characterization-of-novel-anthraquinone-cation-compounds-as-potential-anticancer-agents
#10
Yanyan Zheng, Li Zhu, Lulu Fan, Wenna Zhao, Jianlong Wang, Xianxiao Hao, Yunhui Zhu, Xiufang Hu, Yaofeng Yuan, Jingwei Shao, Wenfeng Wang
Emodin, a natural anthraquinone derivative isolated from Rheum palmatum L., has been demonstrated to exhibit good anti-cancer effect. In this study, a series of novel quaternary ammonium salts of emodin, anthraquinone and anthrone were synthesized and their anticancer activities were tested in vitro. The effects of emodin quaternary ammonium salts on cell viability, apoptosis, intracellular ROS, and mitochondrial membrane potential were investigated in A375, BGC-823, HepG2 and HELF cells. The results demonstrated that compound 4a induced morphological changes and decreased cell viability...
January 5, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27765358/sennoside-a-derived-from-the-traditional-chinese-medicine-plant-rheum-l-is-a-new-dual-hiv-1-inhibitor-effective-on-hiv-1-replication
#11
Francesca Esposito, Ilaria Carli, Claudia Del Vecchio, Lijia Xu, Angela Corona, Nicole Grandi, Dario Piano, Elias Maccioni, Simona Distinto, Cristina Parolin, Enzo Tramontano
BACKGROUND: Despite the availability of effective antiretroviral therapies, drugs for HIV-1 treatment with new mode of action are still needed. An innovative approach is aimed to identify dual HIV-1 inhibitors, small molecules that can inhibit two viral functions at the same time. Rhubarb, originated from Rheum palmatum L. and Rheum officinale Baill., is one of the earliest and most commonly used medicinal plants in Traditional Chinese Medicine (TCM) practice. We wanted to explore TCM for the identification of new chemical scaffolds with dual action abilities against HIV-1...
November 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27706568/comparison-of-methods-to-preserve-rheum-palmatum-polygonaceae-for-efficient-dna-extraction-and-pcr-amplification
#12
M Huang, X J Sun, Y Zhou, X M Wang
In this study, we compared the quality of DNA extracted using the modified CTAB method, from Rheum palmatum leaves preserved using fourteen different methods, including ones used commonly in other species: under ultra-cold (-80°C) temperatures, after drying with an absorbent paper, desiccating using a silica gel, drying at 60°C, in 70% ethanol, absolute ethanol, 70% ethanol supplemented with 50 mM EDTA, SDS-DNA extracting solution, nuclear separation buffer, improved NaCl-CTAB solution, TE-buffer, I-solution, or II-solution...
August 19, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27677719/botanicals-and-their-bioactive-phytochemicals-for-women-s-health
#13
REVIEW
Birgit M Dietz, Atieh Hajirahimkhan, Tareisha L Dunlap, Judy L Bolton
Botanical dietary supplements are increasingly popular for women's health, particularly for older women. The specific botanicals women take vary as a function of age. Younger women will use botanicals for urinary tract infections, especially Vaccinium macrocarpon (cranberry), where there is evidence for efficacy. Botanical dietary supplements for premenstrual syndrome (PMS) are less commonly used, and rigorous clinical trials have not been done. Some examples include Vitex agnus-castus (chasteberry), Angelica sinensis (dong quai), Viburnum opulus/prunifolium (cramp bark and black haw), and Zingiber officinale (ginger)...
October 2016: Pharmacological Reviews
https://www.readbyqxmd.com/read/27633141/the-natural-anthraquinones-from-rheum-palmatum-induced-the-metabolic-disorder-of-melatonin-by-inhibiting-human-cyp-and-sult-enzymes
#14
Weiru Jiang, Xiangge Tian, Yan Wang, Zheng Sun, Peipei Dong, Chao Wang, Xiaokui Huo, Baojing Zhang, Shanshan Huang, Sa Deng, Xiaobo Wang, Xiaochi Ma
Melatonin (Mel) as an endogenous hormone, has been widely used in clinic for multiple therapeutic purposes. Further, the natural anthraquinones were widespread in various plants including herbs, foods, and some flavoring agents. The present work aims to evaluate the metabolic disorder of Mel caused by various common herbs and further identify their underlying mechanism. More importantly, the relationships between inhibitory activity and their structures were also investigated. Our results demonstrate that some herbs containing anthraquinone derivatives exhibited strong inhibition on Mel metabolism...
November 16, 2016: Toxicology Letters
https://www.readbyqxmd.com/read/27626758/the-twist-to-bend-compliance-of-the-rheum-rhabarbarum-petiole-integrated-computations-and-experiments
#15
Tanvir R Faisal, Nicolay Hristozov, Tamara L Western, Alejandro Rey, Damiano Pasini
Plant petioles can be considered as hierarchical cellular structures, displaying geometric features defined at multiple length scales. Their macroscopic mechanical properties are the cumulative outcome of structural properties attained at each level of the structural hierarchy. This work appraises the compliance of a rhubarb stalk by determining the stalk's bending and torsional stiffness both computationally and experimentally. In our model, the irregular cross-sectional shape of the petiole and the layers of the constituent tissues are considered to evaluate the stiffness properties at the structural level...
September 14, 2016: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/27608856/the-korean-herbal-medicine-do-in-seung-gi-tang-attenuates-atherosclerosis-via-ampk-in-high-fat-diet-induced-apoe-mice
#16
Sun Haeng Park, Yoon-Young Sung, Seol Jang, Kyoung Jin Nho, Go Ya Choi, Ho Kyoung Kim
BACKGROUND: Do In Seung Gi-Tang (DISGT) is an herbal mixture of traditional Korean medicine that is composed of Rheum undulatum Linne, Prunus Persica (L.) Batsch, Conyza canadensis L., Cinnamomum Cassia Presl, and Glycytthiza uralensis Fischer (8: 6: 4: 4: 4 ratio). We investigated the effect of DISGT on vascular inflammation and lipid accumulation in apolipoprotein E-deficient (ApoE(-/-)) mice. METHODS: ApoE(-/-) mice that were fed a high-fat diet (HFD) were treated with DISGT (300 mg/kg/day) or statin (10 mg/kg/day) for 16 weeks...
September 8, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27592494/rheum-rhabarbarum-extract-promotes-healing-of-the-incision-through-relieving-inflammation-and-stimulating-angiogenesis
#17
Yingjun Li, Yulan Sun, Hui Ma, Xutao Chen, Jing Liu
As one of the most important treatment strategies in clinic, surgery has improved to be more and more efficient and safe. However, the infection risk of incision caused by surgery is still the main concern of patients. In our research, we found extract of Rheum rhabarbarum (rhubarb) could be used to diminish this risk through promoting the healing of the incision. Using MTT assay, flow cytometry and clinical statics, we also tried to explore the mechanism of rhubarb's effect. The data showed that rhubarb extract decreased the number of leukocytesand neutrophils and inhibited the growth of bacteria...
July 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27582705/a-comprehensive-and-system-review-for-the-pharmacological-mechanism-of-action-of-rhein-an-active-anthraquinone-ingredient
#18
REVIEW
Hao Sun, Guangwen Luo, Dahui Chen, Zheng Xiang
Rhein is a major medicinal ingredient isolated from several traditional Chinese medicines, including Rheum palmatum L., Aloe barbadensis Miller, Cassia angustifolia Vahl., and Polygonum multiflorum Thunb. Rhein has various pharmacological activities, such as anti-inflammatory, antitumor, antioxidant, antifibrosis, hepatoprotective, and nephroprotective activities. Although more than 100 articles in PubMed are involved in the pharmacological mechanism of action of rhein, only a few focus on the relationship of crosstalk among multiple pharmacological mechanisms...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27555350/soluble-epoxide-hydrolase-inhibitory-components-from-rheum-undulatum-and-in-silico-approach
#19
Ah Reum Jo, Jang Hoon Kim, Xi-Tao Yan, Seo Young Yang, Young Ho Kim
Continuous efforts to identify sEH inhibitors using activity-guided fractionation have revealed 12 known compounds, 2-13, from Rheum undulatum. Compounds 2-13 and 1, which was obtained from the in-house library, were tested for inhibitory activity against sEH. Compounds 1-9, 11, and 12 were shown to have inhibitory activity, with IC50 values ranging from 2.5 ± 0.5 to 53.2 ± 4.4 μM. They were subjected to enzyme kinetic studies to explore the binding mode between the ligand and receptor. Based on our results, compounds 1, 2, 5-9, and 11 (mixed type) and compounds 3 and 12 (noncompetitive type) had a preferred allosteric site...
2016: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/27547165/rheum-rhaponticum-extract-err-731-postmarketing-data-on-safety-surveillance-and-consumer-complaints
#20
Jyh-Lurn Chang, Michael B Montalto, Peter W Heger, Eva Thiemann, Reinhard Rettenberger, Jürgen Wacker
CONTEXT: Postmarketing surveillance data for a commercially available extract of Rheum rhaponticum (ERr 731) have not been published since the beginning of the reporting in 1993 in Germany about adverse events (AEs) that were believed to be associated with it. The extract is derived from the plant's roots and is indicated for menopausal relief. In Germany, the extract has been marketed as Phytoestrol N and other related products-Phyto-Strol, Phyto-Strol Loges, and Phyto-Strol compact and as femi-loges...
June 2016: Integrative Medicine
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