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https://www.readbyqxmd.com/read/29743924/emodin-alleviates-liver-fibrosis-of-mice-by-reducing-infiltration-of-gr1-hi-monocytes
#1
Xiang-An Zhao, Guangmei Chen, Yong Liu, Hongyan Wu, Jin Chen, Yali Xiong, Chen Tian, Bei Jia, Guiyang Wang, Juan Xia, Yuxin Chen, Jian Wang, Xiaomin Yan, Zhaoping Zhang, Rui Huang, Chao Wu
Emodin, as a major active component of Rheum palmatum L. and Polygonum cuspidatum , has been reported to have antifibrotic effect. However, the mechanism of emodin on antifibrotic effect for liver fibrosis was still obscure. In the present study, we aimed to investigate whether emodin can alleviate carbon tetrachloride- (CCl4 -) induced liver fibrosis through reducing infiltration of Gr1hi monocytes. Liver fibrosis was induced by intraperitoneal CCl4 injection in mice. Mice in the emodin group received emodin treatment by gavage...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29720825/determination-of-five-chemical-markers-in-df-formula-the-herbal-composition-of-ephedra-intermedia-rheum-palmatum-and-lithospermum-erythrorhizon-using-high-performance-liquid-chromatography-ultraviolet-detection
#2
Birang Jeong, Jong Seong Roh, Michung Yoon, Yoosik Yoon, Soon Shik Shin, Hyun Joo Cho, Yong Soo Kwon, Heejung Yang
Background: DF formula is a herbal preparation comprised three medicinal herbs, namely, Ephedra intermedia , Rheum palmatum , and Lithospermum erythrorhizon , which is being used for the treatment of obesity and liver fibrosis in Korean local clinics. Objective: Since the abovementioned three herbs exist with different proportions in DF formula and their chemical markers have different physiochemical properties; it is quite challenging to develop an analytical methodology for the determination of these chemical markers...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29693154/emodin-inhibits-epithelial%C3%A2-mesenchymal-transition-and-metastasis-of-triple-negative-breast-cancer-via-antagonism-of-cc%C3%A2-chemokine-ligand-5-secreted-from-adipocytes
#3
Xiaoyun Song, Xiqiu Zhou, Yuenong Qin, Jianfeng Yang, Yu Wang, Zhenping Sun, Kui Yu, Shuai Zhang, Sheng Liu
Triple negative breast cancer (TNBC) has the lowest survival rate of the breast cancer subtypes owing to its aggressive and metastatic behavior. It has been reported that peritumoral adipose tissue contributes to the cell invasiveness and dissemination of TNBC. Emodin is an active anthraquinone derivative isolated from Rheum palmatum, with anticancer properties that have been reported to inhibit lung metastasis in a nude mouse xenograft model. In the present study, the effects of emodin on human TNBC cells and adipocytes were investigated in vivo and in vitro...
April 23, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29693149/desoxyrhapontigenin-inhibits-rankl%C3%A2-induced-osteoclast-formation-and-prevents-inflammation%C3%A2-mediated-bone-loss
#4
Phuong Thao Tran, Dong-Hwa Park, Okhwa Kim, Seung-Hae Kwon, Byung-Sun Min, Jeong-Hyung Lee
Desoxyrhapontigenin (DRG), a stilbene compound from Rheum undulatum, has been found to exhibit various pharmacological activities, however, its impact on osteoclast formation has not been investigated. The present study investigated the effect of DRG on receptor activator of nuclear factor‑κB ligand (RANKL)‑induced osteoclast differentiation in mouse bone marrow macrophages (BMMs) and inflammation‑induced bone loss in vivo. BMMs or RAW264.7 cells were treated with DRG, followed by an evaluation of cell viability, RANKL‑induced osteoclast differentiation, actin‑ring formation and resorption pits activity...
April 17, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29669309/emodin-ameliorates-ulcerative-colitis-by-the-flagellin-tlr5-dependent-pathway-in-mice
#5
Shuang Luo, Xiangliang Deng, Qi Liu, Zengfeng Pan, Zhongxiang Zhao, Lian Zhou, Xia Luo
Emodin is an anthraquinone compound derived from Rheum officinale Baill. Several reports showed that emodin had efficacy on acute pancreatitis, keratitis, myocarditis, and rheumatoid arthritis. However, the potency of emodin on ulcerative colitis(UC) remains unclear. In this study, we investigated the effect of emodin on dextran sodium sulfate (DSS)-induced ulcerative colitis in mice. Our results showed that emodin significantly alleviated the symptoms of DSS-induced UC in mice, involving prevented the loss of body weight and colon shortening, decreased the disease activity index (DAI), intestinal damages and the count of white blood cells (WBC) in peripheral blood...
April 15, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29656090/naturally-occurring-compounds-in-differentiation-based-therapy-of-cancer
#6
REVIEW
Sanja Mijatović, Alessia Bramanti, Ferdinando Nicoletti, Paolo Fagone, Goran Kaluđerović, Danijela Maksimović-Ivanić
Differentiation of cancer cells entails the reversion of phenotype from malignant to the original. The conversion to cell type characteristic for another tissue is named transdifferentiation. Differentiation/transdifferentiation of malignant cells in high grade tumor mass could serve as a nonaggressive approach that potentially limits tumor progression and augments chemosensitivity. While this therapeutic strategy is already being used for treatment of hematological cancers, its feasibility for solid malignancies is still debated...
April 12, 2018: Biotechnology Advances
https://www.readbyqxmd.com/read/29600603/-current-research-situation-of-nephrotoxicity-of-chinese-herbal-medicine
#7
Xue Feng, Sai-Nan Fang, Yu-Xin Gao, Jian-Ping Liu, Wei Chen
To provide the basis for the future research on the nephrotoxicity of Chinese herbal medicine through systematic and comprehensive summary of all the Chinese herbal medicines which may lead to nephrotoxicity. Foreign resources included PubMed and Cochrane library, and domestic research resources was China Food and Drug Administration(CDFA) Adverse Drug Reaction Monitoring Center database. The databases were searched from establishment to January 1, 2017. There was no limitation on research type. 28 English studies were found, including 97 Chinese herbs or prescriptions with the risk of nephrotoxicity...
February 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29563980/effect-of-yhhj-on-the-expression-of-the-hepatocellular-bile-acid-transporters-multidrug-resistance-associated-protein-2-and-bile-salt-export-pump-in-ethinylestradiol-induced-cholestasis
#8
Jia Liu, Li-Li Hou, Cui-Ying Zhao
The herbal medicine Yin Huang Mixture (YHHJ; patent no. 200910031240.7) is an aqueous extract composed from various herbs, including Artemisia capillaries Thunb, Hypericum japonicum Thunb, Eucommia ulmoides Oliver, Rheum officinale Baill, Gardenia jasminoides Ellis, Poria cocos Wolf and Dictamnus dasycarpus Turcz. Previous studies have indicated that YHHJ treatment has a beneficial effect on ameliorating itching and reducing serum bile acid levels in patients with intrahepatic cholestasis of pregnancy (ICP)...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29520909/rheum-palmatum-root-extract-inhibits-hepatocellular-carcinoma-in-rats-treated-with-diethylnitrosamine
#9
Mahmoud A El-Saied, Mansour Sobeh, Walied Abdo, Osama M Badr, Lamiaa T Youssif, Ibrahim H Elsayed, Samir M Osman, Michael Wink
OBJECTIVES: The aim of this study was to investigate the potential anticancer properties of a methanol extract of Rheum palmatum roots against diethylnitrosamine (DENA)-induced hepatocellular carcinoma (HCC) in rats and to characterize its phytoconstituents. METHODS: HPLC-PDA-MS/MS was used to profile the secondary metabolites in R. palmatum root extract. HCC was induced using diethylnitrosamine (DENA). The activity of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT), alpha-fetoprotein (AFP), total proteins, serum albumin and serum globulin was determined...
June 2018: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29484828/measuring-person-centred-care-in-nurse-led-outpatient-rheumatology-clinics
#10
Sidona-Valentina Bala, Kristina Forslind, Bengt Fridlund, Peter Hagell
BACKGROUND: Measurement of person-centred care (PCC) outcomes is underdeveloped owing to the complexity of the concept and lack of conceptual clarity. A framework conceptualizing outpatient PCC in rheumatology nurse-led clinics has therefore been suggested and operationalized into the PCC instrument for outpatient care in rheumatology (PCCoc/rheum). OBJECTIVE: The aim of the present study was to test the extent to which the PCCoc/rheum represents the underpinning conceptual outpatient PCC framework, and to assess its measurement properties as applied in nurse-led outpatient rheumatology clinics...
February 27, 2018: Musculoskeletal Care
https://www.readbyqxmd.com/read/29455094/emodin-attenuates-titanium-particle-induced-osteolysis-and-rankl-mediated-osteoclastogenesis-through-the-suppression-of-ikk-phosphorylation
#11
Juehong Li, Yamin Li, Xiaochun Peng, Bin Li, Xiangwei Yuan, Yunsu Chen
Aseptic loosening due to wear particles is a serious challenge for orthopedic surgeons, sabotaging the long-term success of total joint arthroplasty. The existing treatments for aseptic loosening are still far from satisfactory, necessitating more aggressive drug exploration. Here, we examined the effect of emodin on titanium particle-induced osteolysis and further investigated its underlying mechanism in vivo and in vitro. Thirty-two C57BL/6 mice were randomly assigned into four groups: the Sham group (sham operation with vehicle injection), Vehicle group (titanium particle treatment with vehicle injections), Low group (titanium particle treatment with injections of 10 mg/kg/day emodin) and High group (titanium particle treatment with injections of 50 mg/kg/day emodin)...
April 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29417945/emodin-alleviates-alternatively-activated-macrophage-and-asthmatic-airway-inflammation-in-a-murine-asthma-model
#12
Yun-Duan Song, Xiao-Zong Li, Ya-Xian Wu, Yao Shen, Fang-Fang Liu, Pei-Pei Gao, Lei Sun, Feng Qian
Alternatively activated macrophages (AAMs) are not only associated with asthma but also lead to asthmatic airway inflammation and remodeling. Inhibition of AAMs is an alternative therapeutic strategy for treating asthma. In this study we investigated whether emodin (1,3,8-trihydroxy-6-methylanthraquinone), isolated from the rhizome of Rheum palmatum, alleviated asthmatic airway inflammation and reduced AAM polarization in a murine asthma model. Mice were sensitized with a triple allergen mix containing dust mite, ragweed and aspergillus (DRA)...
February 8, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29417713/person-centred-care-in-nurse-led-outpatient-rheumatology-clinics-conceptualization-and-initial-development-of-a-measurement-instrument
#13
Sidona-Valentina Bala, Kristina Forslind, Bengt Fridlund, Karin Samuelson, Björn Svensson, Peter Hagell
BACKGROUND: Person-centred care (PCC) is considered a key component of effective illness management and high-quality care. However, the PCC concept is underdeveloped in outpatient care. In rheumatology, PCC is considered an unmet need and its further development and evaluation is of high priority. The aim of the present study was to conceptualize and operationalize PCC, in order to develop an instrument for measuring patient-perceived PCC in nurse-led outpatient rheumatology clinics. METHODS: A conceptual outpatient PCC framework was developed, based on the experiences of people with rheumatoid arthritis (RA), person-centredness principles and existing PCC frameworks...
February 8, 2018: Musculoskeletal Care
https://www.readbyqxmd.com/read/29402747/estrogenic-activity-of-constituents-from-the-rhizomes-of-rheum-undulatum-linn%C3%A3
#14
SeonJu Park, Yun Na Kim, Hee Jae Kwak, Eun Ju Jeong, Seung Hyun Kim
Stilbenes have been reported to be phytoestrogen compounds owing to its structural similarity to the estrogenic agent diethylstilbestrol. To find new stilbene-derivative phytoestrogens, isolation of stilbene-rich R. undulatum was performed and led to identify six new compounds (1-5 and 28), one newly determined absolute configurations compound (27) together with 21 previously reported compounds (6-26). The structures of compounds were determined on the basis of extensive spectroscopic methods including 1D and 2D NMR and CD spectra data...
February 15, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29376246/-simultaneous-content-determination-of-14-components-in-rhei-radix-et-rhizoma-by-high-performance-liquid-chromatography-method
#15
Yue-Hong Liu, Zheng-Hai Huang, Ling Dong, Wen-Xuan Pei, Yu Sun, Xiao-Yan Gao
To establish an HPLC (high performance liquid chromatography) method for the simultaneous content determination of gallic acid, (+)-catechin, (-)-epicatechin-3-O-gallate, isolindleyin, 4-(4'-hydroxyphenyl)-2-butanone, emodin, chrysophanol, physcion, aloe-emodin, rhein, lindleyin, 4-(4'-hydroxyphenyl)-2-butanone-4'-O-β-D-(2″-O-galloyl-6″-O-cinnamoyl)-glucopyranoside, sennoside A and sennoside B in Rhei Radix et Rhizoma. The analysis was performed on Agilent Zorbax SB-C₁₈ (4.6 mm×150 mm, 5 μm) with 0...
December 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29371580/botanicals-and-phosphonate-show-potential-to-replace-copper-for-control-of-potato-late-blight
#16
Hans-Rudolf Forrer, Susanne Vogelgsang, Tomke Musa
Potato late blight (PLB) caused by Phytophthora infestans (Pi) is the most harmful disease in potato production worldwide. In organic farming, copper is used despite its persistence in soil and toxicity to soil organisms. To replace copper, suspensions of powders from three promising botanicals, including bark of buckthorn ( Frangula alnus , FA), roots of medicinal rhubarb ( Rheum palmatum ) and galls of the nutgall tree ( Galla chinensis ), were tested in multi-year field experiments. The current study shows for the first time that botanicals could replace copper under field conditions and best PLB reduction on leaves was achieved with FA, reaching a level close to that of 2 to 3 kg copper per hectare and year...
November 24, 2017: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29330916/separation-of-three-polar-compounds-from-rheum-tanguticum-by-high-speed-countercurrent-chromatography-with-an-ethyl-acetate-glacial-acetic-acid-water-system
#17
Tao Chen, Ping Wang, Nana Wang, Chongyang Sun, Xue Yang, Hongmei Li, Guoying Zhou, Yulin Li
The separation of polar compounds by high-speed countercurrent chromatography is still regarded as a challenge. In this study, an efficient strategy for the separation of three polar compounds from Rheum tanguticum has been successfully conducted by using high-speed countercurrent chromatography. X-5 macroporous resin chromatography was used for the fast enrichment of the target compounds. Then, the target fraction was directly introduced into high-speed countercurrent chromatography for separation using ethyl acetate/glacial acetic acid/water (100:1:100, v/v/v) as the solvent system...
January 13, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29243069/identification-of-a-new-uncompetitive-inhibitor-of-adenosine-deaminase-from-endophyte-aspergillus-niger-sp
#18
Xin-Guo Zhang, Jin-Wen Liu, Peng Tang, Zi-Yu Liu, Guang-Jun Guo, Qiao-Yun Sun, Jian-Jun Yin
Adenosine deaminase (ADA) is an enzyme widely distributed from bacteria to humans. ADA is known as a potential therapeutic target for the treatment of lymphoproliferative disorders and cancer. Endophytes are endosymbionts, often bacteria or fungi, which live within plant tissues and internal organs or intercellular space. Endophytes have a broad variety of bioactive metabolites that are used for the identification of novel natural compounds. Here, 54 morphologically distinct endophyte strains were isolated from six plants such as Peganum harmala Linn...
December 14, 2017: Current Microbiology
https://www.readbyqxmd.com/read/29208203/effects-of-adding-rheum-officinale-to-angiotensin-converting-enzyme-inhibitors-or-angiotensin-receptor-blockers-on-renal-function-in-patients-with-chronic-renal-failure-a-meta-analysis-of-randomized-controlled-trials
#19
Yue Yang, Ye-Ping Ma, Zheng Zhang, Pei-Lin Dai, Ping Li, Wen-Ge Li
OBJECTIVE: Rheum officinale is a traditional medicinal herb used widely in China to treat chronic renal failure, but the proof of evidence-based medicine is poor. This meta-analysis aims to assess the benefits of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) supplemented with Rheum officinale for delaying the progression of chronic renal failure. MATERIALS AND METHODS: The MEDLINE, EMBASE, Cochrane Library, SinoMed, Chinese National Knowledge Infrastructure, Wanfang, and VIP databases were searched to identify studies published before September 2016 that investigated the effects of ACEI/ARB plus the Chinese patented medicine Rheum (CPM-Rheum) compared to ACEI/ARB alone in lowering serum creatinine (SCr) and blood urea nitrogen (BUN) levels in chronic renal failure patients...
December 6, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/29163548/emodin-alleviates-sodium-taurocholate-induced-pancreatic-acinar-cell-injury-via-microrna-30a-5p-mediated-inhibition-of-high-temperature-requirement-a-transforming-growth-factor-beta-1-inflammatory-signaling
#20
Hong Xiang, Xufeng Tao, Shilin Xia, Jialin Qu, Huiyi Song, Jianjun Liu, Dong Shang
Pancreatitis is an inflammatory disease that is responsible for substantial morbidity and mortality, and it can induce pancreatic necrosis that starts within pancreatic acinar cells in severe cases. Emodin, a pleiotropic natural product isolated from the Chinese herb Rheum palmatum L ., has effective anti-inflammatory activities. In this paper, we investigated the protective effects and molecular mechanism of emodin against sodium taurocholate (STC)-induced pancreatic acinar cells injury in vitro and in vivo ; and the results showed that emodin could significantly alleviate STC-induced pancreatic acinar cells injury through decreasing trypsin, amylase and the release of inflammatory factors (tumor necrosis factor alpha, interleukin-1β, and interleukin-6)...
2017: Frontiers in Immunology
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