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https://www.readbyqxmd.com/read/29330916/separation-of-three-polar-compounds-from-rheum-tanguticum-by-high-speed-counter-current-chromatography-with-an-ethyl-acetate-glacial-acetic-acid-water-system
#1
Tao Chen, Ping Wang, Nana Wang, Chongyang Sun, Xue Yang, Hongmei Li, Guoying Zhou, Yulin Li
The separation of polar compounds by high-speed counter-current chromatography is still regarded as a challenge. In this study, an efficient strategy for the separation of three polar compounds from Rheum tanguticum has been successfully conducted by using high-speed counter-current chromatography. X-5 macroporous resin chromatography was used for the fast enrichment of the target compounds. Then, the target fraction was directly introduced into high-speed counter-current chromatography for separation using ethyl acetate/glacial acetic acid/water (100:1:100, v/v) as the solvent system...
January 13, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29243069/identification-of-a-new-uncompetitive-inhibitor-of-adenosine-deaminase-from-endophyte-aspergillus-niger-sp
#2
Xin-Guo Zhang, Jin-Wen Liu, Peng Tang, Zi-Yu Liu, Guang-Jun Guo, Qiao-Yun Sun, Jian-Jun Yin
Adenosine deaminase (ADA) is an enzyme widely distributed from bacteria to humans. ADA is known as a potential therapeutic target for the treatment of lymphoproliferative disorders and cancer. Endophytes are endosymbionts, often bacteria or fungi, which live within plant tissues and internal organs or intercellular space. Endophytes have a broad variety of bioactive metabolites that are used for the identification of novel natural compounds. Here, 54 morphologically distinct endophyte strains were isolated from six plants such as Peganum harmala Linn...
December 14, 2017: Current Microbiology
https://www.readbyqxmd.com/read/29208203/effects-of-adding-rheum-officinale-to-angiotensin-converting-enzyme-inhibitors-or-angiotensin-receptor-blockers-on-renal-function-in-patients-with-chronic-renal-failure-a-meta-analysis-of-randomized-controlled-trials%C3%A2
#3
Yue Yang, Ye-Ping Ma, Zheng Zhang, Pei-Lin Dai, Ping Li, Wen-Ge Li
OBJECTIVE: Rheum officinale is a traditional medicinal herb used widely in China to treat chronic renal failure, but the proof of evidence-based medicine is poor. This meta-analysis aims to assess the benefits of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) supplemented with Rheum officinale for delaying the progression of chronic renal failure. MATERIALS AND METHODS: The MEDLINE, EMBASE, Cochrane Library, SinoMed, Chinese National Knowledge Infrastructure, Wanfang, and VIP databases were searched to identify studies published before September 2016 that investigated the effects of ACEI/ARB plus the Chinese patented medicine Rheum (CPM-Rheum) compared to ACEI/ARB alone in lowering serum creatinine (SCr) and blood urea nitrogen (BUN) levels in chronic renal failure patients...
December 6, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/29163548/emodin-alleviates-sodium-taurocholate-induced-pancreatic-acinar-cell-injury-via-microrna-30a-5p-mediated-inhibition-of-high-temperature-requirement-a-transforming-growth-factor-beta-1-inflammatory-signaling
#4
Hong Xiang, Xufeng Tao, Shilin Xia, Jialin Qu, Huiyi Song, Jianjun Liu, Dong Shang
Pancreatitis is an inflammatory disease that is responsible for substantial morbidity and mortality, and it can induce pancreatic necrosis that starts within pancreatic acinar cells in severe cases. Emodin, a pleiotropic natural product isolated from the Chinese herb Rheum palmatum L., has effective anti-inflammatory activities. In this paper, we investigated the protective effects and molecular mechanism of emodin against sodium taurocholate (STC)-induced pancreatic acinar cells injury in vitro and in vivo; and the results showed that emodin could significantly alleviate STC-induced pancreatic acinar cells injury through decreasing trypsin, amylase and the release of inflammatory factors (tumor necrosis factor alpha, interleukin-1β, and interleukin-6)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29152137/emodin-and-rhein-decrease-levels-of-hypoxia-inducible-factor-1%C3%AE-in-human-pancreatic-cancer-cells-and-attenuate-cancer-cachexia-in-athymic-mice-carrying-these-cells
#5
Lijuan Hu, Rui Cui, Hongyi Liu, Feng Wang
The transcription factor hypoxia-inducible factor-1 (HIF-1) consists of oxygen-sensitive HIF-1α and constitutive HIF-1β. HIF-1α is undetectable in normal cells, but cancer cells frequently express HIF-1α to support their growth, angiogenesis, and high glycolysis (also known as the Warburg effect). The Warburg effect in cancer cells increases energy expenditure and thus participates in cancer-induced metabolic disorder, cancer cachexia. In the present study, we investigated whether two components of Rheum palmatum, emodin and rhein, inhibited HIF-1α expression in human pancreatic cancer cells and whether the inhibiting effect, if any, attenuated cancer cachexia...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29121121/emodin-reverses-leukemia-multidrug-resistance-by-competitive-inhibition-and-downregulation-of-p-glycoprotein
#6
Hongping Min, Miaomiao Niu, Weilin Zhang, Jia Yan, Jiachang Li, Xiying Tan, Bo Li, Mengxiang Su, Bin Di, Fang Yan
Development of multidrug resistance (MDR) is a continuous clinical challenge partially due to the overexpression of P-glycoprotein (P-gp) for chronic myelogenous leukemia (CML) patients. Herein, we evaluated the inhibitory potency of emodin, a natural anthraquinone derivative isolated from Rheum palmatum L, on P-gp in P-gp positive K562/ADM cells. Competition experiments combined with molecular docking analysis were utilized to investigate the binding modes between emodin and binding sites of P-gp. Emodin reversed adriamycin resistance in K562/ADM cells accompanied with the decrease of P-gp protein expression, further increasing the uptake of rhodamine123 in both K562/ADM and Caco-2 cells, indicating the inhibition of P-gp efflux function...
2017: PloS One
https://www.readbyqxmd.com/read/29090552/-rapid-analysis-on-phenolic-compounds-in-rheum-palmatum-based-on-uplc-q-tof-mse-combined-with-diagnostic-ions-filter
#7
Qing Wang, Zhi-Wei Lu, Yue-Hong Liu, Ming-Ling Wang, Shuang Fu, Qing-Qing Zhang, Hui-Zhen Zhao, Zhi-Xin Zhang, Zi-Ye Xie, Zheng-Hai Huang, Hong-Hong Yu, Wen-Juan Zhou, Xiao-Yan Gao
Diagnostic ions filter method was used to rapidly detect and identify the phenolic compounds in Rheum palmatum based on ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MSE). The representative authentic standards of phenolic compounds, including gallic acid, (+)-catechin, (-)-epicatechin, (-)-epicatechin-3-O-gallate and procyanidin B2, were subjected to analysis by UPLC-Q-TOF/MSE system with negative ion mode. Fragmentation patterns of each standard were summarized based on assigned fragment ions...
May 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29076992/in-silico-uhplc-method-optimization-for-aglycones-in-the-herbal-laxatives-aloe-barbadensis-mill-cassia-angustifolia-vahl-pods-rhamnus-frangula-l-bark-rhamnus-purshianus-dc-bark-and-rheum-palmatum-l-roots
#8
Nadja Meier, Beat Meier, Samuel Peter, Evelyn Wolfram
For the European Pharmacopoeia (Ph. Eur.) herbal monograph draft of Cassia angustifolia Vahl. and Cassia senna L. leaves and pods, a safety limitation of aloe-emodin and rhein was proposed, due to toxicological concerns. A quantitative, analytical method of the anthraquinone aglycones in all Ph. Eur. monographed herbal laxatives is of interest. A rational method development for the aglycones aloe-emodin, rhein, emodin, chrysophanol, and physcion in five herbal drugs was realized by using 3D chromatographic modelling (temperature, solvent, and gradient time) and design of experiment (DOE) software (DryLab(®) 4)...
October 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29071869/-effects-of-wine-processed-rheum-palmatum-on-tissue-distribution-of-aloe-emodin-rhein-and-emodin-in-rats
#9
Yu Wu, Xiao-Qing Peng, Xiao-Yan Jiang, Mei-Qin Shi, Shui-Ying Yang, Ying-Jun Fu, Min Peng, Yan Cai, Sheng-Shi Jiang, Yan Xu
Under the traditional processing theory "wine processing could promote the efficacy", Rhubarb after wine processing could treat the upper energizer diseases such as red swelling, and breath sores. Processing changes the medicinal properties of rhubarb, and thus results in different focuses in clinical application. In this study, a sensitive and specific method was developed for the determination of aloe-emodin, rhein and emodin in rats tissue. Rhubarb raw materials and its wine processed decoction were given to SD rats respectively by gavage administration, and then the contents of aloe-emodin, rhein and emodin in the tissues (heart, lung, brain, liver, kidney) were determined by HPLC-MS to explore the effect of wine processing on free anthraquinones in rat tissues...
April 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28987074/combination-of-rheum-ribes-and-metformin-against-diabetes-thermal-hyperalgesia-and-tactile-allodynia-in-a-mice-model
#10
Karim Raafat, Abdalla El-Lakany
Context • The prevalence of diabetes mellitus (DM) is increasing. Because of its progressive nature, therapeutic shifts and combinations are often required to reduce the risk of glucose toxicity and avoid serious side effects. To treat DM and its related complications, a combination therapy may offer a promising remedy to counteract those issues. Objectives • The study was established to evaluate the phytochemical content of a standardized aqueous extract of Rheum ribes (RR) and to determine the antidiabetic, antihyperalgesic, and antimechanical allodynic effects of 50 mg/kg of RR alone, 25 mg/kg of metformin (MTF) alone, and a combination of the 2 substances (MTF+RR) in mice with alloxan-induced diabetes...
October 2, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28900458/effects-of-angelica-dahurica-and-rheum-officinale-extracts-on-excisional-wound-healing-in-rats
#11
Wan-Ting Yang, Chun-Yen Ke, Wen-Tien Wu, Horng-Jyh Harn, Yi-Hsiung Tseng, Ru-Ping Lee
The main objective of wound treatments is to restore the functional skin properties and prevent infection. Traditional Chinese medicine provides alternative anti-inflammatory, antimicrobial, and wound healing therapies. Both Angelica dahurica extract (AE) and Rheum officinale extract (RE) possess antimicrobial activity. In this study, AE and RE were applied in wound treatment to investigate their healing effects. Thirty Sprague-Dawley rats with dorsal full-thickness skin excision were divided into normal saline (NS), AE, RE, AE plus RE (ARE), and Biomycin (BM) groups...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28861641/medicinal-plant-extracts-modulate-respiratory-burst-and-proliferation-activity-of-rainbow-trout-oncorhynchus-mykiss-leukocytes
#12
Chiara Bulfon, Marco Galeotti, Donatella Volpatti
The present study was designed to investigate the immunomodulatory effects of Aloe vera, Curcuma longa, Echinacea purpurea, Lavandula officinalis, Origanum vulgare, Panax ginseng, and Rheum officinale extracts on leukocytes purified from rainbow trout (Oncorhynchus mykiss) head kidney. The cells were cultured in a medium containing increasing doses of extracts; afterwards, they were tested for reactive oxygen species production after stimulation with phorbol myristate acetate (PMA) and proliferation in the presence or absence of phytohemagglutinin from Phaseolus vulgaris (PHA-P)...
September 1, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28844213/effects-of-rhubarb-rheum-ribes-l-syrup-on-dysenteric-diarrhea-in-children-a-randomized-double-blind-placebo-controlled-trial
#13
Ali Khiveh, Mohammad Hashem Hashempur, Mehrdad Shakiba, Mohammad Hassan Lotfi, Afsaneh Shakeri, SeidKazem Kazemeini, Zohre Mousavi, Marzie Jabbari, Mohammad Kamalinejad, Majid Emtiazy
BACKGROUND: Rheum ribes L. is a plant native to China, Iran, Turkey, India, and a few other countries. Antidiarrheal activity is considered to be one of its important properties according to various systems of traditional medicine. An increasing rate of bacterial resistance to antibiotics has led to treatment failure in some cases of shigellosis in children, and underlines a need for safe, efficient and valid options. OBJECTIVE: The purpose of this study is to evaluate the efficacy of R...
September 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28842339/gangjihwan-a-polyherbal-composition-inhibits-fat-accumulation-through-the-modulation-of-lipogenic-transcription-factors-srebp1c-ppar%C3%AE-and-c-ebp%C3%AE
#14
Jaewoong Jang, Yoonju Jung, Seyeon Chae, Soo Hyun Cho, Michung Yoon, Heejung Yang, Soon Shik Shin, Yoosik Yoon
ETHNOPHARMACOLOGICAL RELEVANCE: Gangjihwan (DF) which is composed of Ephedra intermedia, Lithospermum erythrorhizon, and Rheum palmatum has been used for the treatment of obesity in traditional medical clinics in Korea. AIM OF THE STUDY: This study was conducted to standardize DF and elucidate its mechanism of action for inhibiting fat accumulation in adipocytes and adipose tissues. MATERIALS AND METHODS: The herbal ingredients of DF were extracted in water, 30% ethanol or 70% ethanol and freeze-dried followed by HPLC analyses...
August 24, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28840029/profuse-and-acute-hemorrhagic-gastroesophageal-injury-after-cryotherapy-in-a-cardiac-surgery-patient
#15
Hyae-Jin Kim, Hyeon-Jeong Lee, Dowon Lee, Haekyu Kim, A-Rheum Cho, Soeun Jeon, Suyeon Hong
Upper gastrointestinal injury associated with cryoablation and under placement of transesophageal echocardiography (TEE) during cardiac surgery is a rare complication but potentially fatal. During the cryoablation for the treatment of atrial fibrillation, delivered cryoenergy can adversely affect the esophagus, resulting in gastroesophageal ulceration. The TEE probe itself also can induce adverse effects like esophageal ulceration or perforation. In this case report, we describe a case of emergent gastroesophageal injury with massive bleeding that occurred after manipulation of a TEE probe during cryoablation therapy in a cardiac surgery patient...
July 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28807157/antiinflammatory-and-hepatoprotective-medicinal-herbs-as-potential-substitutes-for-bear-bile
#16
Sandra Appiah, Mike Revitt, Huw Jones, Milan Vu, Monique Simmonds, Celia Bell
Practitioners of traditional Chinese medicine (TCM) commonly prescribe medicinal formulations relying on the purported synergism of a combination of plant species, sometimes incorporating animal parts and minerals. Bear bile, obtained from either wild or farmed bears, is a commonly used constituent of traditional medicine formulations. With several bear species now listed under Convention on International Trade in Endangered Species of Wild Fauna and Flora as threatened with extinction and with bear farming being actively campaigned against on ethical grounds, it is important to seek and promote alternatives to the use of bear bile as medicine...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28803999/growth-arrest-and-morphological-changes-triggered-by-emodin-on-trypanosoma-cruzi-epimastigotes-cultivated-in-axenic-medium
#17
Ana R De Lima, Karem Noris-Suárez, Antonio Bretaña, Victor T Contreras, Maria C Navarro, Luis Pérez-Ybarra, José Bubis
Emodin is an anthraquinone obtained from Rheum palmatum rootstocks. Here we tested the cytotoxic effects of emodin on Trypanosoma cruzi epimastigotes, as well as the morphological changes that were induced by this compound in the parasite. Emodin was permeable and blocked in vitro cell division of T. cruzi epimastigotes in axenic medium, causing growth arrest in a dose-dependent but reversible manner. Emodin-exposed epimastigotes underwent duplication of organelles, such as the nucleus, kinetoplast and flagellum, but were incapable of completing cytokinesis...
November 2017: Biochimie
https://www.readbyqxmd.com/read/28798802/prescribed-renoprotective-chinese-herbal-medicines-were-associated-with-a-lower-risk-of-all-cause-and-disease-specific-mortality-among-patients-with-chronic-kidney-disease-a-population-based-follow-up-study-in-taiwan
#18
Chuan-Fa Hsieh, Huan-Cheng Chang, Song-Lih Huang, Chien-Lung Chen, Wei-Ta Chen, Chen-Chang Yang
Chinese herbal medicines (CHMs) containing aristolochic acid (AA) are associated with chronic kidney disease (CKD), but some prescribed CHMs have been shown to possess renoprotective effects. We conducted a nationwide retrospective cohort study to delineate the role of prescribed CHMs on the CKD progression. Renoprotective CHM (RPCHM) was defined if a CHM contained dong chong xia cao (Cordyceps sinensis (Berk.) Sacc.), da huang (Rheum palmatum L), huang qi (Astragalus membranaceus), dan shen (Salvia miltiorrhiza Bge...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28782194/the-preparation-of-hyaluronic-acid-nanoparticles-from-aspicilia-lichens-using-bifido-bacteria-for-help-in-the-treatment-of-diabetes-in-rats-in-vivo
#19
Akbar Esmaeili, Shirin Rajaee
Many common herbs and spices are claimed to have blood sugar lowering properties that make them useful for people with or at high risk of diabetes. The main of compounds of kiwifruit (Actinidia deliciosa), rhubarb (Rheum ribes), membrane inner of egg shell, wool of sheep, human fingernail (unguis), hyaluronic acid produced by the Bifidobacterium, and usnic acid of Aspicilia lichen were extracted by different methods. All compounds of the extract were divided into five groups. We used variables such as pH, different compounds, concentration, number of injections, and blood glucose monitoring in different situations...
August 7, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28730954/evaluation-of-in-vitro-anti-psoriatic-activity-of-a-novel-polyherbal-formulation-by-multiparametric-analysis
#20
Nadav Shraibom, Alka Madaan, Vidushi Joshi, Ritu Verma, Anika Chaudhary, Gautam Mishra, Anshumali Awasthi, Anu Taneja Singh, Manu Jaggi
The beneficial role of traditional herbal medicines in the treatment of inflammatory skin disorders has been widely reported. Psoriasis is characterized by uncontrolled hyper-proliferation of keratinocytes, disturbed apoptosis, over-secretion of inflammatory cytokines and angiogenic factors. We have developed a novel aqueous polyherbal formulation (SIRB-001) consisting of 3 herbs; Rheum palmatum L., Rehmannia glutinosa Libosch and Lonicera Japonica in the ratio 1:1:3. SIRB-001 has demonstrated efficacious effects in psoriasis patients...
July 20, 2017: Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
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