Kaveh Roshanbinfar, Miriam Schiffer, Esther Carls, Miriam Angeloni, Maria Koleśnik-Gray, Stefan Schruefer, Dirk W Schubert, Fulvia Ferrazzi, Vojislav Krstić, Bernd K Fleischmann, Wilhelm Roell, Felix B Engel
Myocardial infarction (MI) causes cell death, disrupts electrical activity, triggers arrhythmia, and results in heart failure, whereby 50-60% of MI-associated deaths manifest as sudden cardiac deaths (SCD). The most effective therapy for SCD prevention is implantable cardioverter defibrillators (ICDs). However, ICDs contribute to adverse remodeling and disease progression and do not prevent arrhythmia. We developed an injectable collagen-PEDOT:PSS hydrogel that protects infarcted hearts against ventricular tachycardia (VT) and can be combined with hiPSC-cardiomyocytes to promote partial cardiac remuscularization...
April 23, 2024: Advanced Materials