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https://www.readbyqxmd.com/read/28079693/conjunctival-autograft-versus-amniotic-membrane-transplantation-following-double-pterygium-excision-a-randomized-trial
#1
Venkatesh N Prajna, Lumbini Devi, Suganya K Seeniraj, Jeremy D Keenan
No abstract text is available yet for this article.
January 11, 2017: Cornea
https://www.readbyqxmd.com/read/28076785/infection-programs-sustained-lymphoid-stromal-cell-responses-and-shapes-lymph-node-remodeling-upon-secondary-challenge
#2
Julia L Gregory, Anne Walter, Yannick O Alexandre, Jyh Liang Hor, Ruijie Liu, Joel Z Ma, Sapna Devi, Nobuko Tokuda, Yuji Owada, Laura K Mackay, Gordon K Smyth, William R Heath, Scott N Mueller
Lymph nodes (LNs) are constructed of intricate networks of endothelial and mesenchymal stromal cells. How these lymphoid stromal cells (LSCs) regulate lymphoid tissue remodeling and contribute to immune responses remains poorly understood. We performed a comprehensive functional and transcriptional analysis of LSC responses to skin viral infection and found that LSC subsets responded robustly, with different kinetics for distinct pathogens. Recruitment of cells to inflamed LNs induced LSC expansion, while B cells sustained stromal responses in an antigen-independent manner...
January 10, 2017: Cell Reports
https://www.readbyqxmd.com/read/28070850/zolendronic-acid-conjugated-plga-ultrasmall-nanoparticle-loaded-with-methotrexate-as-a-supercarrier-for-bone-targeted-drug-delivery
#3
Vinay Raichur, Kusum Devi Vemula, Naini Bhadri, Rema Razdan
Drug delivery to deep-seated tissues such as bone has been a major complication till date. This preferential drug delivery is further important in targeting anti-tumour agents to bone metastasis owing to its complexity. The present study involves the formulation of PLGA nanoparticles and conjugation with zolendronic acid-a bisphosphonate which will anchor the nanosystem to bone due to its selective bone affinity. The conjugated nanosystem was characterized for particle size by TEM (average 36 nm) and morphology by AFM depicting surface irregularities due to ZOL conjugation on the surface of nanoparticles...
January 9, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28069163/sub-critical-impact-inhibits-the-lubricating-mechanisms-of-articular-cartilage
#4
Edward D Bonnevie, Michelle L Delco, Devis Galesso, Cynthia Secchieri, Lisa A Fortier, Lawrence J Bonassar
Although post-traumatic osteoarthritis accounts for a significant proportion of all osteoarthritis, the understanding of both biological and mechanical phenomena that lead to cartilage degeneration in the years to decades after trauma is still lacking. In this study, we evaluate how cartilage lubrication is altered after a sub-critical impact (i.e., an impact to the cartilage surface that produces surface cracking but not full thickness fissuring). Through utilizing a Stribeck-like framework, the elastoviscous transition, we evaluated changes to both the innate boundary lubricating ability of cartilage after impact and also the effectiveness of high viscosity lubricants to lower friction after impact...
December 29, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/28065811/huge-prostatic-utricle-with-transitional-cell-carcinoma-in-an-adult
#5
Anil Kumar N, Sreeranga Y L, Tyagi A, Vijayalakshmi Devi B
A 21-year-old man with pain lower abdomen and hematuria of 10 days duration was evaluated and found to have large cystic lesion behind the urinary bladder and was confirmed to be a large prostatic utricle with solid component on contrast enhanced computed tomography (CECT), magnetic resonance imaging (MRI) and on Transrectal ultrasonography (TRUS). Post operative histopathology revealed transitional cell carcinoma.
January 5, 2017: Urology
https://www.readbyqxmd.com/read/28065162/validation-of-a-competitive-elisa-and-a-virus-neutralization-test-for-the-detection-and-confirmation-of-antibodies-to-senecavirus-a-in-swine-sera
#6
Melissa Goolia, Fabio Vannucci, Ming Yang, Devi Patnayak, Shawn Babiuk, Charles K Nfon
Senecavirus A (SVA; family Picornaviridae) is a nonenveloped, single-stranded RNA virus associated with idiopathic vesicular disease (IVD) in swine. SVA was detected in pigs with IVD in Brazil, United States, Canada, and China in 2015, triggering the need to develop and/or validate serologic assays for SVA. Our objective was to fully validate a previously developed competitive enzyme-linked immunosorbent assay (cELISA) as a screening test for antibodies to SVA. Additional objectives included the development and validation of a virus neutralization test (VNT) as a confirmatory test for SVA antibody detection, and the comparison of the cELISA, VNT, and an existing immunofluorescent antibody test (IFAT) for the detection of SVA antibodies in serial bleeds from SVA outbreaks...
January 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28064107/ethnomedicine-based-evaluation-of-osteoprotective-properties-of-tinospora-cordifolia-on-in-vitro-and-in-vivo-model-systems
#7
G Abiramasundari, C M Mohan Gowda, G Pampapathi, Sheela Praveen, S Shivamurugan, M Vijaykumar, A Devi, M Sreepriya
Indian ethnomedicine acclaims the use of Tinospora cordifolia (TC) in the treatment of bone fractures and vat rakta (gout). The objective of the study is to investigate the effects of alcoholic extract of Tinospora cordifolia on bone remodeling (involving osteoblastic and osteoclastic actions) in vitro and protect against ovariectomy-induced bone loss in vivo. Human osteoblast-like cells MG-63 and primary osteoblast cells isolated from rat femur were used as osteoblast models and RAW macrophage cell line 264...
January 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28062421/intraoperative-oct-assisted-descemetopexy-with-stromal-vent-incisions-and-intracameral-gas-injection-for-case-of-non-resolving-descemet-s-membrane-detachment
#8
Archita Singh, Murugesan Vanathi, Suman Sahu, Saranya Devi
Descemet's membrane detachment (DMD) though uncommon in the present day scenario of advancing surgical techniques is a significant complication that requires prompt diagnosis and management. A middle-aged man presented to our hospital with poor gain of vision following cataract surgery. There was significant corneal oedema with DMD which was confirmed on anterior segment optical coherence tomography. We describe a modified continuous intraoperative-guided approach for the management of DMD in cases with oedematous hazy corneas...
January 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28059465/rosmarinic-acid-mediates-mitochondrial-biogenesis-in-insulin-resistant-skeletal-muscle-through-activation-of-ampk
#9
Govindaraj Jayanthy, Vellai Roshana Devi, Kaliappan Ilango, Sorimuthu Pillai Subramanian
Rosmarinic acid (RA), a polyphenol, is known to improve hepatic insulin sensitivity in experimental type 2 diabetes. However, its effect on skeletal muscle insulin resistance is meagerly understood. The present study was aimed to investigate the upstream and downstream mediators of the molecular targets of RA in attenuating insulin resistance in the skeletal muscle both in vivo and in vitro. We found that supplementation of RA increased the expression of key genes involved in the mitochondrial biogenesis like PGC-1α, SIRT-1 and TFAM via activation of AMPK in the skeletal muscle of insulin resistant rats as well as in L6 myotubes...
January 6, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28057589/microsurgical-clipping-of-unruptured-intracranial-aneurysms-a-single-surgeon-s-experience-over-sixteen-years
#10
Anil Nanda, Devi Prasad Patra, Shyamal C Bir, Tanmoy K Maiti, Piyush Kalakoti, Papireddy Bollam
INTRODUCTION: Unruptured intracranial aneurysms (UIA) have become an issue of greater significance as their detection rates have increased over the years. We present the overall experience of microsurgical clipping of unruptured aneurysms by a single surgeon over a period of more than 16 years. METHODS: The clinical and radiological data were retrospectively reviewed. Clinical outcome at follow-up was assessed by Glasgow Outcome Scale (GOS), and angiograms were reviewed for the degree of occlusion...
January 2, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28056738/microtubule-targeting-agents-as-cancer-chemotherapeutics-an-overview-of-molecular-hybrids-as-stabilising-and-destabilising-agents
#11
Anjana Devi Tangutur, Dinesh Kumar, Kommalapati Vamsi Krishna, Srinivas Kantevari, Anjana Devi Tangutur, Dinesh Kumar, Kommalapati Vamsi Krishna, Srinivas Kantevari
Microtubules form crucial dynamic structural cellular components of the cell and are composed of the alpha beta tubulin heterodimers. Microtubules are involved in a wide variety of functions in the cell such as attribution to cell shape, motility, intracellular trafficking and mitotic spindle formation. Owing to these reasons, tubulin and microtubules have gained significant interest as important targets for cancer therapy. A review of the existing microtubule targeting drugs specifies that these agents can be categorised into two of the major categories: Microtubule stabilising agents such as paclitaxel, docetaxel, epothilones, and discodermolide which bind to the tubulin polymer and stabilize the microtubules, microtubule destabilising agents such as vinca alkaloids, colchicine and combretastatins which bind to tubulin dimers and cause destabilisation...
January 4, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28050843/evaluating-the-probiotic-and-therapeutic-potentials-of-saccharomyces-cerevisiae-strain-obs2-isolated-from-fermented-nectar-of-toddy-palm
#12
Banoth Srinivas, Ganapathiwar Swarupa Rani, Bhukya Kiran Kumar, Banoth Chandrasekhar, Kommalapati Vamsi Krishna, Tangutur Anjana Devi, Bhukya Bhima
The purpose of this study is to evaluate the probiotic characteristics of 15 yeast strains isolated from nectar of toddy palm. Initially, the collected samples were inoculated on yeast extract peptone dextrose agar plates and the colonies so obtained were culturally and morphologically characterized. Commercial probiotic yeast, Saccharomyces boulardii served as the control in these experiments. Of the 15 yeast strains, the isolates that were resistant to antibiotics and worked synergistically with other cultures were considered for further evaluation...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28050726/preoperative-chemotherapy-and-survival-for-large-anorectal-gastrointestinal-stromal-tumors-a-national-analysis-of-333-cases
#13
Alexander T Hawkins, Katerina O Wells, Devi Mukkai Krishnamurty, Steven R Hunt, Matthew G Mutch, Sean C Glasgow, Paul E Wise, Matthew L Silviera
PURPOSE: Anorectal gastrointestinal stromal tumors (GISTs) are exceedingly rare, and management remains controversial in regard to local resection (LR) and preoperative chemotherapy. METHODS: The National Cancer Data Base was queried from 1998 to 2012 for cases of GIST resection in the rectum or anus. Patient demographics, type of surgery (LR vs. radical excision [RE]), short-term outcomes, and overall survival (OS) were analyzed. Preoperative chemotherapy was recorded following the US FDA approval of imatinib in 2002...
January 3, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28049468/mandatory-tb-notification-in-mysore-city-india-have-we-heard-the-private-practitioner-s-plea
#14
Sarabjit Singh Chadha, Sharath Burugina Nagaraja, Archana Trivedi, Sachi Satapathy, Devendrappa N M, Karuna Devi Sagili
BACKGROUND: The Government of India, made TB notification by private healthcare providers mandatory from May 2012 onwards. The National TB Programme developed a case based web based online reporting mechanism called NIKSHAY. However, the notification by private providers has been very low. We conducted the present study to determine the awareness, practice and anticipated enablers related to TB notification among private practitioners in Mysore city during 2014. METHODS: A cross-sectional study was conducted among private practitioners of Mysore city in south India...
January 3, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28043985/in-vivo-confocal-microscopy-appearance-of-fusarium-and-aspergillus-species-in-fungal-keratitis
#15
Jaya Devi Chidambaram, Namperumalsamy Venkatesh Prajna, Natasha Larke, David Macleod, Palepu Srikanthi, Shruti Lanjewar, Manisha Shah, Prajna Lalitha, Shanmugam Elakkiya, Matthew J Burton
BACKGROUND: Clinical outcomes in fungal keratitis vary between Fusarium and Aspergillus spp, therefore distinguishing between species using morphological features such as filament branching angles, sporulation along filaments (adventitious sporulation) or dichotomous branching may be useful. In this study, we assessed these three features within Heidelberg Retina Tomograph 3 in vivo confocal microscopy (IVCM) images from culture-positive Fusarium and Aspergillus spp keratitis participants...
January 2, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28034886/sustained-antibody-responses-six-years-following-one-two-or-three-doses-of-quadrivalent-hpv-vaccine-in-adolescent-fijian-girls-and-subsequent-responses-to-a-single-dose-of-bivalent-hpv-vaccine-a-prospective-cohort-study
#16
Zheng Quan Toh, Fiona M Russell, Rita Reyburn, James Fong, Evelyn Tuivaga, Tupou Ratu, Cattram D Nguyen, Rachel Devi, Mike Kama, Silivia Matanitobua, Sepehr N Tabrizi, Suzanne M Garland, Rohit Sinha, Ian Frazer, Lisi Tikoduadua, Joseph Kado, Eric Rafai, Edward K Mulholland, Paul V Licciardi
BACKGROUND: The antibody response following reduced HPV vaccine doses has not been determined. We compared the antibody responses in girls previously vaccinated with zero, one, two or three doses of 4vHPV (Gardasil(®),Merck Inc.) six years previously. METHODS: A prospective cohort study was undertaken in 200 Fijian girls (15-19 years old). Approximately equal numbers of girls from two main ethnic groups (Fijians-of-Indian-Descent;FIDs) and (Indigenous-Fijians;iTaukei) in Fiji were recruited for each dosage groups...
December 28, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28033379/targeting-a-hidden-enemy-pyriproxyfen-autodissemination-strategy-for-the-control-of-the-container-mosquito-aedes-albopictus-in-cryptic-habitats
#17
Kshitij Chandel, Devi Shankar Suman, Yi Wang, Isik Unlu, Eric Williges, Gregory M Williams, Randy Gaugler
BACKGROUND: The Asian tiger mosquito, Aedes albopictus, is a vector of dengue, Chikungunya, and Zika viruses. This mosquito inhabits a wide range of artificial water-holding containers in urban and suburban areas making it difficult to control. We tested the hypothesis that female-driven autodissemination of an insect growth regulator could penetrate cryptic oviposition habitats difficult to treat with conventional insecticidal sprays. METHODOLOGY: Oviposition preferences of Ae...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28031601/undergraduate-pharmacology-curriculum-at-an-international-medical-college-in-india
#18
Vasudha Devi, Vishal Bhat, Ganesh K Shenoy
Pharmacology is an important aspect of rational therapeutics. There has been a long-standing need for a change in the undergraduate medical curriculum of pharmacology. A review of literature throws up different approaches to improve the curriculum and to provide more importance to conceptualization and relevance to clinical practice. This article describes the undergraduate pharmacology curriculum which is revised to meet the needs of our unique status as an international medical college in India. We highlight how our curriculum prepares the students for future clinical practice by inculcating higher cognitive skills and soft skills...
October 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28029420/early-dural-metastasis-from-a-case-of-glioblastoma-with-primitive-neuroectodermal-differentiation-a-case-report-and-literature-review
#19
Subhas K Konar, Shyamal C Bir, Tanmoy K Maiti, Devi Prasad Patra, Angela C DiPoto Brahmbhatt, Jamie A Jacobsohn, Anil Nanda
Glioblastoma with a primitive neuroectodermal (PNET) variant is a rare primary parenchymal tumor. Only a few cases of extraparenchymal metastasis are reported in world literature. Although the overall survival duration of glioblastoma multiforme (GBM) with primitive neuroectodermal tumor (PNET) variety may be prolonged in comparison to classical glioblastoma, the metastatic trend is completely different, and the prognosis is worse. We report an early dural metastasis of pure PNET component appearing in a case of primary glioblastoma with PNET variant...
October 28, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28029245/selective-binding-of-genomic-escherichia-coli-dna-with-zno-leads-to-white-light-emission-a-new-aspect-of-nano-bio-interaction-and-interface
#20
Sumita Das, Srikrishna Pramanik, Sabyasachi Chatterjee, Partha Pratim Das, Parukuttyamma Sujatha Devi, Gopinatha Suresh Kumar
Here, we report for the first time, a novel and intriguing application of deoxyribonucleic acid (DNA) in the area of optics by demonstrating white light emission by tuning the emission of a nanomaterial, ZnO rods, exhibiting surface defects, in the presence of genomic Escherichia coli DNA with a comparatively high quantum efficiency. In order to understand the DNA specificity, we have also studied the interaction of ZnO with CT, and ML DNA, ss EC DNA, synthetic polynucleotides and different mononucleosides and bases...
December 28, 2016: ACS Applied Materials & Interfaces
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