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https://www.readbyqxmd.com/read/29150429/cgamp-a-tale-of-two-signals
#1
Teneema Kuriakose, Thirumala-Devi Kanneganti
In this issue of JEM, Swanson et al. (https://doi.org/10.1084/jem.20171749) report an unanticipated role for cGAMP in priming and activation of inflammasomes in addition to its well-characterized function as an endogenous second messenger inducing type I interferons in the cytosolic DNA-sensing pathway.
November 17, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29150331/anti-amyloidogenic-and-anti-apoptotic-effect-of-%C3%AE-bisabolol-against-a%C3%AE-induced-neurotoxicity-in-pc12-cells
#2
Balakrishnan Shanmuganathan, Venkatesan Suryanarayanan, Sethuraman Sathya, Muralidharan Narenkumar, Sanjeev Kumar Singh, Kandasamy Ruckmani, Kasi Pandima Devi
Alzheimer's disease (AD) is a life-threatening neurodegenerative disorder leading to dementia, with a progressive decline in memory and other thinking skills of elderly populace. Of the multiple etiological factors of AD, the accumulation of senile plaques (SPs) particularly as Aβ oligomers correlates with the relentlessness cognitive impairment in AD patients and play a vital role in AD pathology. Since natural essential oil constituents have successfully served as a source of drugs for AD treatment, the present study aims at the in vitro and in silico investigation of anti-amyloidogenic potential and anti-apoptotic property of the α-bisabolol against Aβ25-35 induced neurotoxicity in PC12 cells...
October 10, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29148421/a-validation-study-of-the-simple-psoriatic-arthritis-screening-sipas-questionnaire-to-screen-psoriasis-patients-for-psoriatic-arthritis
#3
Fausto Salaffi, Marco Di Carlo, Michele Maria Luchetti, Eleonora Di Donato, Anna Campanati, Devis Benfaremo, Massimiliano Nicolini, Marina Carotti, Alfredo Giacchetti, Giulia Ganzetti, Leonardo Bugatti, Armando Gabrielli, Anna Maria Offidani
OBJECTIVES: To validate in a multicentric cohort of patients a self-administered PsA screening tool, called Simple Psoriatic Arthritis Screening (SiPAS) questionnaire, to screen psoriasis patients for signs and symptoms of PsA. METHODS: The SiPAS questionnaire was validated in a multicentric Italian cohort of psoriasis patients referred to two rheumatological centres. RESULTS: A total of 202 psoriasis patients were screened with SiPAS in the validation study...
November 16, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29146436/rupture-of-intra-ventricular-hydatid-cyst-the-camalote-sign
#4
Nishanth Sadashiva, Dhaval Shukla, Bhagavatula Indira Devi
Only a few cases of intraventricular hydatid cysts have been described. The Camalote or waterlily sign is described when there is detachment of the endocyst membrane, resulting in a floating appearance like a waterlily. This sign has been described most commonly in hepatic cysts. Here, we describe the camalote sign in an iatrogenically ruptured intraventricular hydatid cyst. Rupture of an intraventricular hydatid cyst poses the threat of widespread dissemination and is described in our case.
November 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29137517/the-new-way-of-governing-global-health-governing-global-health-who-runs-the-world-and-why-by-chelsea-clinton-and-devi-sridhar-new-york-ny-oxford-university-press-2017-304-pp-24-95
#5
https://www.readbyqxmd.com/read/29133823/identification-of-mirna-mediated-drought-responsive-multi-tiered-regulatory-network-in-drought-tolerant-rice-nagina-22
#6
Sonia Balyan, Mukesh Kumar, Roseeta Devi Mutum, Utkarsh Raghuvanshi, Priyanka Agarwal, Saloni Mathur, Saurabh Raghuvanshi
Comparative characterization of microRNA-mediated stress regulatory networks in contrasting rice cultivars is critical to decipher plant stress response. Consequently, a multi-level comparative analysis, using sRNA sequencing, degradome analysis, enzymatic and metabolite assays and metal ion analysis, in drought tolerant and sensitive rice cultivars was conducted. The study identified a group of miRNAs "Cultivar-specific drought responsive" (CSDR)-miRNAs (osa-miR159f, osa-miR1871, osa-miR398b, osa-miR408-3p, osa-miR2878-5p, osa-miR528-5p and osa-miR397a) that were up-regulated in the flag-leaves of tolerant cultivar, Nagina 22 (N22) and Vandana, but down-regulated in the sensitive cultivar, Pusa Basmati 1 (PB1) and IR64, during drought...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29133708/demonstration-of-autonomic-dysfunction-in-traumatic-brachial-plexus-injury-using-quantitative-sudomotor-axon-reflex-test-preliminary-results
#7
Satyakam Baruah, Akhil Deepika, Dhaval Shukla, Bhagavatula Indira Devi, Veeramani Preethish-Kumar, Talakad N Sathyaprabha
OBJECTIVE: To objectively document autonomic dysfunction in the affected arm with traumatic brachial plexus injury (TBPI) using quantitative sudomotor axon reflex test (QSART). MATERIALS AND METHODS: Patients with TBPI presenting to the neurosurgical outpatient department from August 2013 to November 2014 were included in the study. The QSART was administered to each patient with prior informed consent detailing the procedure. A total of 20 patients with TBPI were included in the study...
November 2017: Neurology India
https://www.readbyqxmd.com/read/29133642/frequency-of-primary-mutations-of-leber-s-hereditary-optic-neuropathy-patients-in-north-indian-population
#8
Anushree Mishra, Saranya Devi, Rohit Saxena, Neerja Gupta, Madhulika Kabra, Madhumita Roy Chowdhury
PURPOSE: Leber's hereditary optic neuropathy (LHON) is an inherited optic neuropathy characterized by subacute painless vision loss. The majority of LHON is caused due to one of the three primary mutations in the mitochondrial DNA (m.G3460A, m.G11778A, and m.T14484C). The frequency of these mutations differs in different populations. The purpose of this study is to observe the frequency of three common primary mutations in the North Indian population. METHODS: Forty LHON patients within the age group of 10-50 years underwent molecular testing for primary mutations...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29128729/recent-advances-in-inflammasome-biology
#9
REVIEW
David E Place, Thirumala-Devi Kanneganti
The inflammasome is a complex of proteins that through the activity of caspase-1 and the downstream substrates gasdermin D, IL-1β, and IL-18 execute an inflammatory form of cell death termed pyroptosis. Activation of this complex often involves the adaptor protein ASC and upstream sensors including NLRP1, NLRP3, NLRC4, AIM2, and pyrin, which are activated by different stimuli including infectious agents and changes in cell homeostasis. Here we discuss new regulatory mechanisms that have been identified for the canonical inflammasomes, the most recently identified NLRP9b inflammasome, and the new gasdermin family of proteins that mediate pyroptosis and other forms of regulated cell death...
November 9, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29124628/chronic-intermittent-hypoxia-exposure-induces-kidney-injury-in-growing-rats
#10
Neha-Devi Poonit, Yi-Chun Zhang, Chu-Yuan Ye, Hui-Lin Cai, Chen-Yi Yu, Ting Li, Xiao-Hong Cai
OBJECTIVE: The objectives of this paper are to examine the effect of chronic intermittent hypoxia (CIH) on the morphological changes in the kidney of growing rats and to explore the mechanisms underlying the CIH-induced renal damage. METHODS: Forty Sprague-Dawley rats were randomly divided into two groups: 2 and 4 weeks CIH groups (2IH, 4IH), and in the control group 2 and 4 weeks air-stimulated groups (2C, 4C), with 10 rats in each group. Pathological changes of renal tissue were observed by HE staining, PAS staining, and Masson staining...
November 9, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29120083/isolation-and-evolutionary-analysis-of-australasian-topotype-of-bluetongue-virus-serotype-4-from-india
#11
Y V Reddy, B Susmitha, S Patil, Y Krishnajyothi, K Putty, K V Ramakrishna, G Sunitha, B V Devi, K Kavitha, B Deepthi, S Krovvidi, Y N Reddy, G H Reddy, K P Singh, N S Maan, D Hemadri, S Maan, P P Mertens, N R Hegde, P P Rao
Bluetongue (BT) is a Culicoides-borne disease caused by several serotypes of bluetongue virus (BTV). Similar to other insect-borne viral diseases, distribution of BT is limited to distribution of Culicoides species competent to transmit BTV. In the tropics, vector activity is almost year long, and hence, the disease is endemic, with the circulation of several serotypes of BTV, whereas in temperate areas, seasonal incursions of a limited number of serotypes of BTV from neighbouring tropical areas are observed...
November 9, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29112879/myocardial-strain-computed-at-multiple-spatial-scales-from-tagged-magnetic-resonance-imaging-estimating-cardiac-biomarkers-for-crt-patients
#12
Matthew Sinclair, Devis Peressutti, Esther Puyol-Antón, Wenjia Bai, Simone Rivolo, Jessica Webb, Simon Claridge, Thomas Jackson, David Nordsletten, Myrianthi Hadjicharalambous, Eric Kerfoot, Christopher A Rinaldi, Daniel Rueckert, Andrew P King
Abnormal cardiac motion can indicate different forms of disease, which can manifest at different spatial scales in the myocardium. Many studies have sought to characterise particular motion abnormalities associated with specific diseases, and to utilise motion information to improve diagnoses. However, the importance of spatial scale in the analysis of cardiac deformation has not been extensively investigated. We build on recent work on the analysis of myocardial strains at different spatial scales using a cardiac motion atlas to find the optimal scales for estimating different cardiac biomarkers...
October 31, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/29112844/polycyclic-aromatic-hydrocarbons-in-house-dust-and-surface-soil-in-major-urban-regions-of-nepal-implication-on-source-apportionment-and-toxicological-effect
#13
Ishwar Chandra Yadav, Ningombam Linthoingambi Devi, Jun Li, Gan Zhang
Urban centers have turned to be the provincial store for resource consumptions and source releases of different types of semi-volatile organic compounds (SVOCs) including polycyclic aromatic hydrocarbons (PAHs), bringing about boundless environmental pollutions, among different issues. Human prosperity inside urban communities is unambiguously dependent on the status of urban soils and house dusts. However, environmental occurrence and sources of release of these SVOCs are challenging in Nepalese cities, as exceptionally very limited data are accessible...
November 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29111974/architecture-of-taf11-taf13-tbp-complex-suggests-novel-regulation-properties-of-general-transcription-factor-tfiid
#14
Kapil Gupta, Aleksandra A Watson, Tiago Baptista, Elisabeth Scheer, Anna L Chambers, Christine Koehler, Juan Zou, Ima Obong-Ebong, Eaazhisai Kandiah, Arturo Temblador, Adam Round, Eric Forest, Petr Man, Christoph Bieniossek, Ernest D Laue, Edward A Lemke, Juri Rappsilber, Carol V Robinson, Didier Devys, Làszlò Tora, Imre Berger
General transcription factor TFIID is a key component of RNA polymerase II transcription initiation. Human TFIID is a megadalton-sized complex comprising TATA-binding protein (TBP) and 13 TBP-associated factors (TAFs). TBP binds to core promoter DNA, recognizing the TATA-box. We identified a ternary complex formed by TBP and the histone fold (HF) domain-containing TFIID subunits TAF11 and TAF13. We demonstrate that TAF11/TAF13 competes for TBP binding with TATA-box DNA, and also with the N-terminal domain of TAF1 previously implicated in TATA-box mimicry...
November 7, 2017: ELife
https://www.readbyqxmd.com/read/29111262/overcoming-monocarboxylate-transporter-8-mct8-deficiency-to-promote-human-oligodendrocyte-differentiation-and-myelination
#15
Jae Young Lee, Min Joung Kim, Devy Deliyanti, Michael F Azari, Fernando Rossello, Adam Costin, Georg Ramm, Edouard G Stanley, Andrew G Elefanty, Jennifer L Wilkinson-Berka, Steven Petratos
Cell membrane thyroid hormone (TH) transport can be facilitated by the monocarboxylate transporter 8 (MCT8), encoded by the solute carrier family 16 member 2 (SLC16A2) gene. Human mutations of the gene, SLC16A2, result in the X-linked-inherited psychomotor retardation and hypomyelination disorder, Allan-Herndon-Dudley syndrome (AHDS). We posited that abrogating MCT8-dependent TH transport limits oligodendrogenesis and myelination. We show that human oligodendrocytes (OL), derived from the NKX2.1-GFP human embryonic stem cell (hESC) reporter line, express MCT8...
October 19, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29111151/experimental-optimization-of-lornoxicam-liposomes-for-sustained-topical-delivery
#16
Joshny Joseph, Vedha Hari B N, Ramya Devi D
The purpose of the present investigation is to formulate liposomes of Lornoxicam for topical delivery using Central Composite Design, to provide a sustained release of the drug and thereby extend its elimination half-life. Liposomes were prepared by thin film hydration method with pH induced vesiculation. The liposomes were assessed for their particle size, charge, morphology and drug entrapment and characterized using TGA-DSC and FTIR analysis, to assess the interaction between the drug and excipients. The in vitro release study was performed using modified USP dissolution apparatus-I using three different dissolution media and the ex vivo release study was performed using goat skin...
October 27, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29110865/establishing-a-cohort-in-a-developing-country-experiences-of-the-diabetes-tuberculosis-treatment-outcome-cohort-study
#17
Fatima Mukhtar, Zahid A Butt
BACKGROUND: Prospective cohort studies are instrumental in generating valid scientific evidence based on identifying temporal associations between cause and effect. Researchers in a developing country like Pakistan seldom undertake cohort studies hence little is known about the challenges encountered while conducting them. We describe the retention rates among tuberculosis patients with and without diabetes, look at factors associated with loss to follow up among the cohort and assess operational factors that contributed to retention of cohort...
December 2017: Journal of Epidemiology and Global Health
https://www.readbyqxmd.com/read/29110624/recent-advancements-in-organotin-iv-complexes-as-potential-anticancer-agents
#18
Jai Devi, Jyoti Yadav
Cancer is a multistep disease incorporating physical, chemical, environmental, metabolic and genetic factors, which play direct or indirect role in the induction and deterioration of cancer. Many of the platinum based drugs were synthesized but due to their systemic toxicity, broad spectrum of action, intrinsic and acquired drug resistivity, it has become necessary to search for the effective anticancer drugs with superior efficiency. Among non-platinum metal compounds with antitumor activity, organotin complexes have proven effective management of toxicity, specific targeted drug uptake by the cancerous cell line and significant potential in the pharmaceutical chemistry...
November 6, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29109143/microrna-874-mediated-inhibition-of-the-major-g1-s-phase-cyclin-ccne1-is-lost-in-osteosarcomas
#19
Tanushree Ghosh, Akhil Varshney, Praveen Kumar, Manpreet Kaur, Vipin Kumar, Ritu Shekhar, Raksha Devi, Priyanka Priyanka, Md Muntaz Khan, Sandeep Saxena
The tumor microenvironment is characterized by nutrient-deprived conditions in which the cancer cells have to adapt for survival. Serum starvation resembles the growth factor deprivation characteristic of the poorly vascularized tumor microenvironment and has aided in the discovery of key growth regulatory genes and microRNAs (miRNAs) that have a role in the oncogenic transformation. We report here that miR-874 downregulates the major G1/S phase cyclin, cyclin E1 (CCNE1), during serum starvation. Since the adaptation of cancer cells to the tumor microenvironment is vital for subsequent oncogenesis, we tested for miR-874 and CCNE1 interdependence in osteosarcoma cells...
November 6, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29108253/identification-of-lrp-1-as-an-endocytosis-and-recycling-receptor-for-%C3%AE-1-integrin-in-thyroid-cancer-cells
#20
Louis Theret, Albin Jeanne, Benoit Langlois, Cathy Hachet, Marion David, Michel Khrestchatisky, Jérôme Devy, Emonard Hervé, Sébastien Almagro, Stéphane Dedieu
LRP-1 is a large endocytic receptor mediating the clearance of various molecules from the extracellular matrix. LRP-1 was reported to control focal adhesion turnover to optimize the adhesion-deadhesion balance to support invasion. To better understand how LRP-1 coordinates cell-extracellular matrix interface, we explored its ability to regulate cell surface integrins in thyroid carcinomas. Using an antibody approach, we demonstrated that β1-integrin levels were increased at the plasma membrane under LRP1 silencing or upon RAP treatment, used as LRP-1 antagonist...
October 3, 2017: Oncotarget
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