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Yamuna Devi Bakthavatchalam, Boopalan Ramaswamy, Rajinikanth Janakiraman, Runal John Steve, Balaji Veeraraghavan
OBJECTIVE: Glycopeptides are being increasingly used to multi-resistant MRSA infections. We report MRSA with low level teicoplanin resistance recovered from a patient treated with teicoplanin for fatal necrotizing fasciitis. PATIENT AND METHODS: MRSA recovered from a patient with necrotizing fasciitis was treated with teicoplanin. The minimum inhibitory concentration (MIC) for vancomycin and teicoplanin was determined using E-test. Reduced glycopeptide susceptibility was screened using GRD E-test and population analysis profile (PAP) method...
May 15, 2018: Journal of Global Antimicrobial Resistance
Sarita Devi, Aneesia Varkey, M S Sheshshayee, Thomas Preston, Anura V Kurpad
Background: Recent evaluations of the risk of dietary protein deficiency have indicated that protein digestibility may be a key limiting factor in the provision of indispensable amino acids (IAAs), particularly for vulnerable populations living in challenging environments where intestinal dysfunction may exist. Since the digestion of protein occurs only in the small intestine, and the metabolic activity of colonic bacteria confounds measurements at the fecal level, there is a need to develop noninvasive protein digestibility measurements at the ileal level...
May 15, 2018: American Journal of Clinical Nutrition
Raghavender Medishetty, Zongji Zhang, Alexander Sadlo, Stefan Cwik, Daniel Peeters, Sebastian Henke, Nagarathinam Mangayarkarasi, Anjana Devi
Fabrication of three-dimensional metal-organic framework (MOF) thin films has been investigated for the first time through the conversion of a ZnO layer via a pure vapour-solid deposition reaction at ambient pressure. The fabrication of MOF thin films with a dicarboxylate linker, (DMA)2[Zn3(bdc)4] (1) (bdc = 1,4-benzenedicarboxylate), and a carboxy-pyrazolate linker, [Zn4O(dmcapz)6] (2) (dmcapz = 3,5-dimethyl-4-carboxypyrazole), involves the deposition of the linker and/or the preparation of a composite film preliminarily and its subsequent conversion into a MOF film using closed cell thermal treatment...
May 17, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Samhita Panda, Mandaville Gourie-Devi, Ankkita Sharma
Background: Amyotrophic lateral sclerosis (ALS) is a relatively rare neurological disorder affecting upper and lower motor neurons in the brain and spinal cord with survival for 3-5 years and rarely beyond 10 years. Sleep disturbances in ALS are underreported and undertreated and there is no related data from India. This study aimed to assess the frequency of sleep disorders in patients of ALS and their determinants. Methods: Patients with definite and probable ALS as per the El Escorial criteria were recruited from May 2014 to April 2016...
May 2018: Neurology India
Gopal Krishnan, Dhananjaya I Bhat, B Indira Devi
No abstract text is available yet for this article.
May 2018: Neurology India
P Narendran, Archana Rajendran, Mirna Garhnayak, Lokanath Garhnayak, J Nivedhitha, K Chandra Devi, Deepak K Pattanayak
Here, effect of solution pH on precipitation of silver decorated hydroxyapatite (Ag-HAp) nano powder during its wet-synthesis was systematically studied. XRD pattern of Ag-HAp nano powder synthesised at pH ranging from 5 to 10 shows that calcium hydrogen phosphate was formed as dominating phase when the solution pH was between 5 and 9 and this phase was gradually transformed into a stable HAp above pH 9. A quantitative analysis of silver amount in Ag-HAp nano powder synthesised at different pH showed that silver can be precipitated to its maximum amount at pH 8 and the further addition of ammonia leads to the formation of a silver-ammonium complex, thereby remaining in the solution...
April 22, 2018: Colloids and Surfaces. B, Biointerfaces
Kavita Devi, A Padhye, P G Schunemann, M Ebrahim-Zadeh
We report the generation of tunable continuous-wave (cw) mid-infrared (mid-IR) radiation across 4608-4694 nm using the new nonlinear material, orientation-patterned gallium phosphide (OP-GaP). By exploiting difference-frequency mixing between a cw Tm-fiber laser and a home-built cw optical parametric oscillator in a 40-mm-long crystal, we have generated up to 43 mW of cw output power, with >30  mW across >95% of the mid-IR tuning range. The output at 4608 nm exhibits high beam quality with a passive power stability of 2...
May 15, 2018: Optics Letters
Kavita Devi, Vinoth Rajendran, T M Rangarajan, Rishi Pal Singh, Prahlad C Ghosh, Manjula Singh
A new class of compounds comprising two series of chalcones with 2,2,2-trifluoroethoxy group and 2-fluoroethoxy groups were synthesized and screened for in vitro antiplasmodial activity against Plasmodium falciparum (3D7) using the [³H] hypoxanthine incorporation inhibition assay. Chalcones with 2,2,2-trifluoroethoxy groups substituted on the p - and m -positions of the 1-phenyl ring showed weak antiplasmodial activity, while compounds substituted on the o -position of the 1-phenyl ring displayed enhanced antiplasmodial activity, thus indicating that 2,2,2-trifluoroethoxy groups on the 1-phenyl ring of chalcones show position-dependent antiplasmodial activity...
May 14, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Lokesh S Nehete, Dhananjay I Bhat, M S Gopalakrishnan, Dhaval Shukla, Subhas Konar, Prashant Singh, Bhagavatula Indira Devi
Introduction: High cervical myelopathy can be rarely caused by the developmental anomalies of atlas. Patients with C1 arch stenosis can present in early childhood or later in life. In symptomatic patients, posterior decompression at atlas is mandatory. We report the first clinical series of 20 patients of C1 arch stenosis in the English literature. Materials and Methods: This is retrospective case series having a cohort of 20 patients with congenital C1 arch stenosis...
January 2018: Journal of Craniovertebral Junction and Spine
Meenal Dhall, Kshetrimayum Surmala Devi, Nilupher, Urvashi Gupta, Renu Tyagi, Satwanti Kapoor
AIM: Study aims to assess the association of various adiposity markers with blood pressure levels. STUDY DESIGN: The present study was a cross-sectional study conducted in Delhi. A total of 568 (males- 250, females- 318) participants aged 20-55 years were enrolled for the study. RESULT: Mean height (167.35 ± 7.59) and weight (73.76 ± 15.08) was found to be significantly higher in males. Mean values of minimum waist circumference (183...
May 5, 2018: Diabetes & Metabolic Syndrome
Arasi Thangavelu, Steven Rosenbaum, Devi Thangavelu
BACKGROUND: Cholecystitis is an inflammation of the gallbladder that most commonly occurs as a result of obstruction of the cystic duct by gallstones. The current standard of treatment for acute cholecystitis is cholecystectomy. OBJECTIVE: Our goal was to discuss the benefits of and compare early laparoscopic cholecystectomy and delayed laparoscopic cholecystectomy in the treatment of acute cholecystitis. MATERIALS AND METHODS: A Medline literature search was performed dating from January 1982 to July 2015...
May 8, 2018: Journal of Emergency Medicine
Rajendra Singh, Deepak Pandey, Neena Devi, Duni Chand
Butyramide is a commodity chemical having wide range of applications from material science to biological sciences including synthesis of therapeutic drugs, hydroxamic acids, and electrorheological fluids. The nitrile hydratase protein of Bacillus sp. APB-6 was explored to develop an efficient biocatalytic process for the biotransformation of butyronitrile to butyramide using free and immobilized cells. The reaction conditions for nitrile hydratase activity were not affected after immobilization of the free cells and the optimum pH and temperature for both free and immobilized cells were 8...
May 10, 2018: Bioprocess and Biosystems Engineering
Jyothshna Devi Katamreddy, Prasanna Raju Yalavarthi, Subba Rao D, Sowjanya Battu, Jaya Preethi Peesa
During the twenty-first century, drug discovery is expanding rapidly and a large number of chemical moieties are recognized. Many of them are poorly soluble and hence related biopharmaceutical constraints are to be addressed systematically. Among novel approaches to resolving biopharmaceutical issues, micro- and nano-emulsified systems serve as the best strategy for delivering both hydrophobic and hydrophilic drugs owing to their greater solubilization and transportation capabilities. Of late, the unique physical and biopharmaceutical properties of these liquid isotropic homogenous systems have gained substantive research importance...
May 10, 2018: Lipids in Health and Disease
Devis Benfaremo, Lucia Manfredi, Michele Maria Luchetti, Armando Gabrielli
BACKGROUND: Immune checkpoint inhibitors are a new promising class of antitumor drugs that have been associated to a number of immune-related adverse events (AEs), including musculoskeletal and rheumatic disease. METHODS: We searched Medline reviewing reports of musculoskeletal and rheumatic AEs induced by immune checkpoint inhibitors. RESULTS: Several musculoskeletal and rheumatic AEs associated with immune checkpoint inhibitors treatment are reported in literature...
May 8, 2018: Current Drug Safety
Nirmala Jagadish, Rukhsar Fatima, Aditi Sharma, Sonika Devi, Vitusha Suri, Vikash Kumar, Anil Suri
SPAG9 is a novel tumor associated antigen, expressed in variety of malignancies. However, its role in ovarian cancer remains unexplored. SPAG9 expression was validated in ovarian cancer cells by real time PCR and Western blot. SPAG9 involvement in cell cycle, DNA damage, apoptosis, paclitaxel sensitivity and epithelial- mesenchymal transition (EMT) was investigated employing RNA interference approach. Combinatorial effect of SPAG9 ablation and paclitaxel treatment was evaluated in in vitro. Quantitative PCR and Western blot analysis revealed SPAG9 expression in A10, SKOV-3 and Caov3 compared to normal ovarian epithelial cells...
May 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Subhas K Konar, B N Nandeesh, M Sandhya, N Chandana, B Indira Devi, Dhananjaya I Bhat
Pilocytic astrocytoma is a benign low-grade tumor with a favorable prognosis. We present a 47-year-old- lady with a posterior fossa pilocytic astrocytoma who underwent surgical decompression. She developed multiple early local recurrences Along with malignant transformation of the cranial lesion she developed skeletal dissemination within a very short time frame. There were no features or family history of neurofibromatosis 1. She did not receive radiotherapy or chemotherapy prior to the recurrences.
May 10, 2018: British Journal of Neurosurgery
P R K Bhargav, M Sabaretnam, V Amar, N Vimala Devi
Introduction: Primary hyperparathyroidism is one of the most common endocrine disorders requiring surgical parathyroidectomy for its definitive treatment. Surgical exploration is traditionally performed through conventional open neck approach. A wide range of minimal access and minimally invasive endoscopic techniques (gas less and with gas) have been attempted in the past two decades. In this context, we evaluated the feasibility and safety of an innovative transoral endoscopic parathyroidectomy (EP) technique, which represents a paradigm shift in transluminal endocrine surgery...
May 4, 2018: Journal of Minimal Access Surgery
Balaji Veeraraghavan, Mark Ranjan Jesudason, John Antony Jude Prakasah, Shalini Anandan, Rani Diana Sahni, Agila Kumari Pragasam, Yamuna Devi Bakthavatchalam, Rajesh Joseph Selvakumar, T N Dhole, Camilla Rodrigues, Indranil Roy, Sangeetha Joshi, Bhaskar Narayan Chaudhuri, D S Chitnis
Background: The emergence of antibiotic resistance among bacterial pathogens in the hospital and community has increased the concern to the health-care providers due to the limited treatment options. Surveillance of antimicrobial resistance (AMR) in frequently isolated bacterial pathogens causing severe infections is of great importance. The data generated will be useful for the clinicians to decide empiric therapy on the local epidemiological resistance profile of the antimicrobial agents...
January 2018: Indian Journal of Medical Microbiology
Kedir N Turi, Jyoti Shankar, Larry J Anderson, Devi Rajan, Kelsey Gaston, Tebeb Gebretsadik, Suman R Das, Cosby Stone, Emma K Larkin, Christian Rosas-Salazar, Steven M Brunwasser, Martin L Moore, R Stokes Peebles, Tina V Hartert
RATIONALE: Recurrent wheeze and asthma are thought to result from alterations in early life immune development following RSV infection, however, prior studies of the nasal immune-response to infection have assessed only individual cytokines, which doesn't capture the whole spectrum of response to infection. OBJECTIVE: To identify nasal immune phenotypes in response to RSV infection and their association with recurrent wheeze. METHODS: A birth cohort of term healthy infants born June-December were recruited and followed to capture the first infant RSV infection...
May 7, 2018: American Journal of Respiratory and Critical Care Medicine
Aparna K Sanath, A Santha Devy, Sanath Aithal, G Sathish Kumar, B Ganesh Prasad, P S Pradeep
Background: Pemphigus is a group of autoimmune blistering diseases characterized by loss of keratinocyte cell adhesion that leads to blister formation clinically. Induction of apoptosis or of proapoptotic proteins by pemphigus immunoglobulin G (IgG) may be part of the mechanism by which IgG induces acantholysis. Some of the current data suggest that activation of proapoptotic proteins such as bax and caspase cysteine proteinases may sensitize cells to the acantholytic effects of pemphigus IgG...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
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