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https://www.readbyqxmd.com/read/28645621/two-delta-opioid-receptor-subtypes-are-functional-in-single-ventral-tegmental-area-neurons-and-can-interact-with-the-mu-opioid-receptor
#1
Elyssa B Margolis, Wakako Fujita, Lakshmi A Devi, Howard L Fields
The mu and delta opioid receptors (MOR and DOR) are highly homologous members of the opioid family of GPCRs. There is evidence that MOR and DOR interact, however the extent to which these interactions occur in vivo and affect synaptic function is unknown. There are two stable DOR subtypes: DPDPE sensitive (DOR1) and deltorphin II sensitive (DOR2); both are blocked by DOR selective antagonists. Robust motivational effects are produced by local actions of both MOR and DOR ligands in the ventral tegmental area (VTA)...
June 20, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28636882/foxn1-italian-founder-mutation-in-indian-family-implications-in-prenatal-diagnosis
#2
Akella Radha Rama Devi, Nagesh Narayan Panday, Shaik Mohammad Naushad
The Forkhead box N1 (FOXN1) is a transcriptional factor regulating the development, differentiation and function of thymic epithelial cells; maintaining T-lineage progenitors in bone marrow; promoting terminal differentiation of epithelial cells of hair follicles. Mutation in FOXN1 was reported to cause a rare disorder characterized by rudimentary thymus gland, T-cell immunodeficiency, congenital alopecia and nail dystrophy within an Italian community. This is the first report of FOXN1 p.R255X mutation from India, outside this endogamous Italian community...
June 18, 2017: Gene
https://www.readbyqxmd.com/read/28636644/longitudinal-changes-in-physical-activity-sedentary-behavior-and-body-mass-index-in-adolescence-migrations-towards-different-weight-cluster
#3
José Devís-Devís, Jorge Lizandra, Alexandra Valencia-Peris, Esther Pérez-Gimeno, Xavier García-Massò, Carmen Peiró-Velert
This study examined longitudinal changes in physical activity, sedentary behavior and body mass index in adolescents, specifically their migrations towards a different weight cluster. A cohort of 755 adolescents participated in a three-year study. A clustering Self-Organized Maps Analysis was performed to visualize changes in subjects' characteristics between the first and second assessment, and how adolescents were grouped. Also a classification tree was used to identify the behavioral characteristics of the groups that changed their weight cluster...
2017: PloS One
https://www.readbyqxmd.com/read/28634194/zbp1-dai-ubiquitination-and-sensing-of-influenza-vrnps-activate-programmed-cell-death
#4
Sannula Kesavardhana, Teneema Kuriakose, Clifford S Guy, Parimal Samir, R K Subbarao Malireddi, Ashutosh Mishra, Thirumala-Devi Kanneganti
Innate sensing of influenza virus infection induces activation of programmed cell death pathways. We have recently identified Z-DNA-binding protein 1 (ZBP1) as an innate sensor of influenza A virus (IAV). ZBP1-mediated IAV sensing is critical for triggering programmed cell death in the infected lungs. Surprisingly, little is known about the mechanisms regulating ZBP1 activation to induce programmed cell death. Here, we report that the sensing of IAV RNA by retinoic acid inducible gene I (RIG-I) initiates ZBP1-mediated cell death via the RIG-I-MAVS-IFN-β signaling axis...
June 20, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28629020/a-comparative-in-vivo-evaluation-of-bioactive-glasses-and-bioactive-glass-based-composites-for-bone-tissue-repair
#5
Devis Bellucci, Alexandre Anesi, Roberta Salvatori, Luigi Chiarini, Valeria Cannillo
In this work a set of novel materials for bone tissue regeneration have been tested in vivo in an animal model. In fact, despite many studies have been devoted to amorphous 45S5 Bioglass®, there is lack in the literature of works aimed to study the in vivo performance of heat-treated - and thus partially crystallized - 45S5. As widely reported, crystallization limits the bioactivity of 45S5 and is the main reason that prevents a broader use of this material. Thus, in the present work, a recently developed bioactive glass (BG_Ca/Mix) is tested, since previous investigations demonstrated that BG_Ca/Mix is particularly promising by virtue of both its high bioactivity and lower tendency to crystallize with respect to 45S5...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28627047/hysterectomy-trends-in-australia-2000-01-to-2013-14-joinpoint-regression-analysis
#6
Louise Forsyth Wilson, Nirmala Pandeya, Gita Devi Mishra
INTRODUCTION: Hysterectomy is a common gynecological procedure, particularly in middle and high income countries. The aim of this paper was to describe and examine hysterectomy trends in Australia from 2000-01 to 2013-14. MATERIAL AND METHODS: For women aged 25 years and over, data on the number of hysterectomies performed in Australia annually were sourced from the National Hospital and Morbidity Database. Age-specific and age-standardized hysterectomy rates per 10,000 women were estimated with adjustment for hysterectomy prevalence in the population...
June 19, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28620262/prevalence-of-multiple-drug-resistant-streptococcus-suis-in-and-around-guwahati-india
#7
Mrinalee Devi, Jyoti B Dutta, Swaraj Rajkhowa, Dhireswar Kalita, Girindra Kumar Saikia, Bipin Chandra Das, Razibuddin Ahmed Hazarika, Gauranga Mahato
AIM: This study was conducted to determine the prevalence and antimicrobial susceptibility of Streptococcus suis and their resistance patterns isolated from both clinically healthy carriers and diseased pigs in and around Guwahati, Assam, India. MATERIALS AND METHODS: A total of 497 samples were collected during October, 2012, to April, 2014, from clinically healthy (n=67) and diseased (n=230) pigs of varying age and either sex maintained under organized and unorganized farming systems...
May 2017: Veterinary World
https://www.readbyqxmd.com/read/28616255/global-health-governance-in-the-sustainable-development-goals-is-it-grounded-in-the-right-to-health
#8
Remco Van de Pas, Peter S Hill, Rachel Hammonds, Gorik Ooms, Lisa Forman, Attiya Waris, Claire E Brolan, Martin McKee, Devi Sridhar
This paper explores the extent to which global health governance - in the context of the early implementation of the Sustainable Development Goals is grounded in the right to health. The essential components of the right to health in relation to global health are unpacked. Four essential functions of the global health system are assessed from a normative, rights-based, analysis on how each of these governance functions should operate. These essential functions are: the production of global public goods, the management of externalities across countries, the mobilization of global solidarity, and stewardship...
January 2017: Global Chall
https://www.readbyqxmd.com/read/28615886/first-record-on-the-occurrence-of-ryukyua-circularis-pillai-1954-a-parasitic-cymothoid-crustacean-isopoda-infesting-the-clupeid-fish-amblygaster-sirm-walbaum-from-andaman-islands-india
#9
J Praveenraj, K Saravanan, P Puneeth Kumar, S Ravichandran, Arunjyoti Baruah, S Monalisha Devi, R Kiruba Sankar, S Dam Roy
In the present study, occurrence of branchial parasitic cymothoid, Ryukyua circularis from the marine finfish, Amblygaster sirm is reported for the first time from Andaman Islands. Morphological characterization was carried out which confirmed the parasite as R. circularis. Molecular characterization using 28S rDNA revealed 443 bp sequence which has been submitted to NCBI GenBank under the accession no. KX090447. Ten female and one male parasite (R. circularis) were collected from the branchial cavity of the individual host fishes (A...
June 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28615826/mnemonics-for-gillies-principles-of-plastic-surgery-and-it-importance-in-residency-training-programme
#10
Sandhya Pandey, Ravi Kumar Chittoria, Devi Prasad Mohapatra, M T Friji, Dinesh Kumar Sivakumar
No abstract text is available yet for this article.
January 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/28615806/proposal-of-a-new-classification-scheme-for-periocular-injuries
#11
Devi Prasad Mohapatra, Friji Meethale Thiruvoth, Ravi Kumar Chittoria, S Dinesh Kumar, Sudhanva Hemant Kumar, Senthil Kumar, Preethitha Babu, Elan Kumar
BACKGROUND: Eyelids are important structures and play a role in protecting the globe from trauma, brightness, in maintaining the integrity of tear films and moving the tears towards the lacrimal drainage system and contribute to aesthetic appearance of the face. Ophthalmic trauma is an important cause of morbidity among individuals and has also been responsible for additional cost of healthcare. Periocular trauma involving eyelids and adjacent structures has been found to have increased recently probably due to increased pace of life and increased dependence on machinery...
January 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/28615208/deficiency-of-the-nod-like-receptor-nlrc5-results-in-decreased-cd8-t-cell-function-and-impaired-viral-clearance
#12
Christopher R Lupfer, Kate L Stokes, Teneema Kuriakose, Thirumala-Devi Kanneganti
Pathogen recognition receptors are vital components of the immune system. Engagement of these receptors is important not only for instigation of innate immune responses to invading pathogens but also for initiating the adaptive immune response. Members of the NOD-like receptor (NLR) family of pathogen recognition receptors have important roles in orchestrating this response. The NLR family member, NLRC5 regulates major histocompatibility complex class I (MHC-I) expression during various types of infections, but its role in immunity to influenza A virus (IAV) is not well studied...
June 14, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28611451/beta-sitosterol-and-daucosterol-phytosterols-identified-in-grewia-tiliaefolia-perturbs-cell-cycle-and-induces-apoptotic-cell-death-in-a549-cells
#13
Tamilselvam Rajavel, Ramar Mohankumar, Govindaraju Archunan, Kandasamy Ruckmani, Kasi Pandima Devi
Lung cancer is the leading cause of cancer related deaths both in developed and developing countries. Since majority of the existing therapeutic methods harms both normal and malignant cells, a viable alternative is to switch into safe and beneficial traditional medicinal plants. Hence the present study was framed to identify selective anti-lung cancer agents from the medicinal plant Grewia tiliaefolia (GT). Cell viability experiments showed that benzene extract of GT (BGT) leaf effectively inhibited the growth of A549 cells, while being non-toxic to normal human lung L132 and PBMC cells...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28610306/typhlocarcinus-kerala-a-new-species-of-rhizopine-crab-from-southwestern-india-and-the-identity-of-t-craterifer-rathbun-1914-crustacea-brachyura-pilumnidae
#14
Peter K L Ng, Suvarna Devi, Appukuttannair Biju Kumar
A new species of rhizopine crab of the genus Typhlocarcinus Stimpson, 1858 (family Pilumnidae), is described from southwestern India. Typhlocarcinus kerala sp. nov. is characterised by its granular carapace with the dorsal regions well demarcated and the gastro-cardiac grooves deep, the anterolateral margin entire and prominently granulated, the posterolateral margin lacks a low granulated lobe, proportions of the ambulatory legs and shape of the female telson.
May 26, 2017: Zootaxa
https://www.readbyqxmd.com/read/28607467/changes-in-novel-haematological-parameters-following-thermal-injury-a-prospective-observational-cohort-study
#15
R J Dinsdale, A Devi, P Hampson, C M Wearn, A L Bamford, J Hazeldine, J Bishop, S Ahmed, C Watson, J M Lord, N Moiemen, P Harrison
The mortality caused by sepsis is high following thermal injury. Diagnosis is difficult due to the ongoing systemic inflammatory response. Previous studies suggest that cellular parameters may show promise as diagnostic markers of sepsis. The aim of this study was to evaluate the effect of thermal injury on novel haematological parameters and to study their association with clinical outcomes. Haematological analysis was performed using a Sysmex XN-1000 analyser on blood samples acquired on the day of the thermal injury to 12 months post-injury in 39 patients (15-95% TBSA)...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28606320/lice-induced-immuno-oxidative-wreckage-of-goats
#16
Y Ajith, U Dimri, Shanker K Singh, A Gopalakrishnan, Gopinath Devi, M R Verma, Vivek Joshi, Shahjahan Alam
The present study aimed to evaluate the immuno-oxidative patho-biology of lice infestation in goats. Sixty goats were divided into five groups; sucking lice (Linognathus africanus) infested (Group 1, n=12), chewing lice (Bovicola caprae) infested-mild (Group 2, n=12), chewing lice (B. caprae) infested-moderate (Group 3, n=12), chewing lice (B. caprae) infested-severe (Group 4, n=12) and healthy control (Group 5, n=12). To assess the pathological changes, markers of oxidative stress (lipid peroxidation-LPO, reduced glutathione-GSH, superoxide dismutase-SOD, Catalase-CAT and total antioxidant capacity-TAC), the markers of immune status (Tumour necrosis factor alpha- TNF-α, Interleukin-10- IL-10, Transforming growth factor beta 1- TGF-β1, ratios of TNF-α/IL-10 and TNF-α/TGF-β1) and hemato-biochemical status were evaluated...
August 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28599841/changing-paradigm-in-the-management-of-elderly-patients-with-intracranial-aneurysms-an-institutional-review
#17
Oleg Y Chernyshev, Shyamal C Bir, Tanmoy K Maiti, Devi Prasad Patra, Cesar Liendo, Hugo Cuellar, Alireza Minagar, Anil Nanda
Optimal treatment of intracranial aneurysms (IAs) in elderly patients has not yet been well established. We have investigated the clinical and radiological outcomes and predictors of unfavorable outcome of IAs in elderly patients. Radiological and clinical data of 85 elderly patients from 2010 through 2015 were retrospectively reviewed. Significant differences between the groups were determined by a chi-square test. Regression analysis was performed to identify the predictors of unfavorable outcome. Among the 85 patients with IAs, the number of patients with >7mm size aneurysm (p=0...
June 6, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28598238/nlrc3-regulates-cellular-proliferation-and-apoptosis-to-attenuate-the-development-of-colorectal-cancer
#18
Rajendra Karki, R K Subbarao Malireddi, Qifan Zhu, Thirumala-Devi Kanneganti
Nucleotide-binding domain, leucine-rich-repeat-containing proteins (NLRs) are intracellular innate immune sensors of pathogen-associated and damage-associated molecular patterns. NLRs regulate diverse biological processes such as inflammatory responses, cell proliferation and death, and gut microbiota to attenuate tumorigenesis. In a recent publication in Nature, we identified NLRC3 as a negative regulator of PI3K-mTOR signaling and characterized its potential tumor suppressor function. Enterocytes lacking NLRC3 cannot control cellular proliferation because they are unable to suppress activation of PI3K-mTOR signaling pathways...
June 9, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28597727/influence-of-groundnut-bud-necrosis-virus-on-the-life-history-traits-and-feeding-preference-of-its-vector-thrips-palmi-karny
#19
Guisuibou Daimei, Harpreet Singh Raina, Pushpa Devi Pukhrambam, Gunjan Kumar Saurav, Perumal Renukadevi, Varagur Ganesan Malathi, Chinniah Senthilraja, Bikash Mandal, Rajagopal Raman
The effect of Groundnut bud necrosis virus (GBNV) infection on the life history traits of its vector Thrips palmi and its feeding preference on GBNV-infected plants were studied. A significant difference was observed in the developmental period (1st instar to adult) between the GBNV-infected and healthy thrips, wherein the developmental period of GBNV-infected thrips was decreased. However, there was no effect on the other parameters such as pre-adult mortality, adult longevity and fecundity. Further investigation on settling and feeding choice assay of T...
June 9, 2017: Phytopathology
https://www.readbyqxmd.com/read/28597122/nanoparticle-in-gel-system-for-delivery-of-vitamin-c-for-topical-application
#20
Sanjukta Duarah, Ramya Devi Durai, VedhaHari B Narayanan
Hyperpigmentation is a dermal condition of melanocyte proliferation, induced by various factors like ultraviolet radiation producing reactive oxygen species, DNA damage, and apoptosis. The application of topical antioxidants through the different type of formulations can help to prevent oxidative damage to the skin. L-ascorbic acid (vitamin C) is a water-soluble compound and the most abundant antioxidant in human skin, but this vitamin is unstable and loses its potency with poor formulation strategies. Nanotechnology has been effectively used to promote stability and therapeutic activity of various drug molecules...
June 8, 2017: Drug Delivery and Translational Research
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