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https://www.readbyqxmd.com/read/28633105/effects-of-triacontanol-on-ascorbate-glutathione-cycle-in-brassica-napus-l-exposed-to-cadmium-induced-oxidative-stress
#1
Elham Asadi Karam, Viviana Maresca, Sergio Sorbo, Batool Keramat, Adriana Basile
The ability of exogenous triacontanol (TRIA), a plant growth regulator, to reduce Cd toxicity was studied in canola (Brassica napus L.) plants. The following biological parameters were examined in canola seedlings to investigate TRIA-induced tolerance to Cd toxicity: seedling growth, chlorophyll damage and antioxidant response. In particular, TRIA application reduced Cd-induced oxidative damage, as shown by reduction of ROS content, lipoxygenase (LOX) activity and lipid peroxidation level. TRIA pretreatment increased non-enzymatic antioxidant contents (ascorbate, AsA, glutathione and GSH), phytochelatin content (PCs) and activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX), guaiacol peroxidase (GPX), monodehydroascorbate reductase (MDHAR), dehydro ascorbate reductase (DHAR), and glutathione reductase (GR), so reducing the oxidative stress...
June 17, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28611302/the-peripheral-immune-status-of-granulocytic-myeloid-derived-suppressor-cells-correlates-the-survival-in-advanced-gastric-cancer-patients-receiving-cisplatin-based-chemotherapy
#2
Hirokazu Shoji, Kohei Tada, Shigehisa Kitano, Takashi Nishimura, Yasuhiro Shimada, Kengo Nagashima, Kazunori Aoki, Nobuyoshi Hiraoka, Yoshitaka Honma, Satoru Iwasa, Atsuo Takashima, Ken Kato, Narikazu Boku, Kazufumi Honda, Tesshi Yamada, Yuji Heike, Tetsuya Hamaguchi
BACKGROUND: The prognostic significance of peripheral immune status in patients with advanced gastric cancer (AGC) remains unclear. RESULTS: From July 2013 through December 2014, 37 patients were enrolled. Among patients with 25 subsets of immune cells, patients in the high group of granulocytic myeloid-derived suppressor cells (Gr-MDSCs) showed significantly shorter progression-free survival (PFS) than those in the low group (3.98 vs. 8.78 months; hazards ratio (HR), 2...
May 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28600624/desflurane-usage-during-anesthesia-with-and-without-n2o-using-flow-i-automatic-gas-control-with-three-different-wash-in-speeds
#3
Robrecht De Medts, Rik Carette, Andre M De Wolf, Jan F A Hendrickx
AGC(®) (Automatic Gas Control) is the FLOW-i's automated low flow tool (Maquet, Solna, Sweden) that target controls the inspired O2 (FIO2) and end-expired desflurane concentration (FAdes) while (by design) exponentially decreasing fresh gas flow (FGF) during wash-in to a maintenance default FGF of 300 mL min(-1). It also offers a choice of wash-in speeds for the inhaled agents. We examined AGC performance and hypothesized that the use of lower wash-in speeds and N2O both reduce desflurane usage (Vdes). After obtaining IRB approval and patient consent, 78 ASA I-II patients undergoing abdominal surgery were randomly assigned to 1 of 6 groups (n = 13 each), depending on carrier gas (O2/air or O2/N2O) and wash-in speed (AGC speed 2, 4, or 6) of desflurane, resulting in groups air/2, air/4, air/6, N2O/2, N2O/4, and N2O/6...
June 9, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28593558/combined-effect-of-pulse-density-and-grid-cell-size-on-predicting-and-mapping-aboveground-carbon-in-fast-growing-eucalyptus-forest-plantation-using-airborne-lidar-data
#4
Carlos Alberto Silva, Andrew Thomas Hudak, Carine Klauberg, Lee Alexandre Vierling, Carlos Gonzalez-Benecke, Samuel de Padua Chaves Carvalho, Luiz Carlos Estraviz Rodriguez, Adrián Cardil
BACKGROUND: LiDAR remote sensing is a rapidly evolving technology for quantifying a variety of forest attributes, including aboveground carbon (AGC). Pulse density influences the acquisition cost of LiDAR, and grid cell size influences AGC prediction using plot-based methods; however, little work has evaluated the effects of LiDAR pulse density and cell size for predicting and mapping AGC in fast-growing Eucalyptus forest plantations. The aim of this study was to evaluate the effect of LiDAR pulse density and grid cell size on AGC prediction accuracy at plot and stand-levels using airborne LiDAR and field data...
December 2017: Carbon Balance and Management
https://www.readbyqxmd.com/read/28591657/agc-kinases-mechanisms-of-regulation-%C3%A2-and-innovative-drug-development
#5
REVIEW
Alejandro E Leroux, Jörg Schulze, Ricardo M Biondi
The group of AGC kinases consists of 63 evolutionarily related serine/threonine protein kinases comprising PDK1, PKB/Akt, SGK, PKC, PRK/PKN, MSK, RSK, S6K, PKA, PKG, DMPK, MRCK, ROCK, NDR, LATS, CRIK, MAST, GRK, Sgk494, and YANK, while two other families, Aurora and PLK, are the most closely related to the group. Eight of these families are physiologically activated downstream of growth factor signaling, while other AGC kinases are downstream effectors of a wide range of signals. The different AGC kinase families share aspects of their mechanisms of inhibition and activation...
June 4, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28585197/human-protein-kinases-and-obesity
#6
Atilla Engin
The action of protein kinases and protein phosphatases is essential for multiple physiological responses. Each protein kinase displays its own unique substrate specificity, and a regulatory mechanism that may be modulated by association with other proteins. Protein kinases are classified by the target amino acid in their substrates. Some protein kinases can phosphorylate both serine/threonine, as well as tyrosine residues. This group of kinases has been known as dual specificity kinases. Unlike the dual specificity kinases, a heterogeneous group of protein phosphatases are known as dual-specificity phosphatases...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28584889/associations-between-early-tumor-shrinkage-and-depth-of-response-and-clinical-outcomes-in-patients-treated-with-1st-line-chemotherapy-for-advanced-gastric-cancer
#7
Hiroki Osumi, Daisuke Takahari, Eiji Shinozaki, Keisho Chin, Mariko Ogura, Takeru Wakatsuki, Takashi Ichimura, Izuma Nakayama, Tomohiro Matsushima, Kensei Yamaguchi
BACKGROUND: Although early tumor shrinkage (ETS) predictions of the efficacy and depth of response (DpR) reflects clinical outcomes in chemotherapy with epidermal growth factor receptor inhibitor regimens to treat metastatic colorectal cancer, their value in assessing treatments for advanced gastric cancer (AGC) is unclear. Here we evaluated relationships between ETS and DpR and clinical outcomes in AGC patients treated with first-line chemotherapy. METHODS: We retrospectively enrolled 612 consecutive patients treated with first-line chemotherapy for AGC between January 2010 and June 2016...
June 5, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28580567/cytohistological-discrepancies-of-cervico-vaginal-smears-and-hpv-status
#8
İbrahim Alanbay, Mustafa Öztürk, Fahri Burçin Fıratlıgil, Kazım Emre Karaşahin, Müfit Cemal Yenen, Serkan Bodur
OBJECTIVES: Discrepancies between abnormal cervical cytology or high-risk human papillomavirus (HR-HPV) status (cytolo-gy negative/HPV positive) and subsequent histological findings are a common occurrence. After using co-testing, the dis-crepancies between the HR-HPV status and cervical cytology have become an issue. In this study, we aimed to determine the characteristics of women with a discrepancy between histology and cytology/HR-HPV status, in terms of diagnosis, review and identification...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28579171/the-ndr-lats-protein-kinases-in-immunology-and-cancer-biology
#9
REVIEW
Ahmad A D Sharif, Alexander Hergovich
The NDR (nuclear Dbf2-related)/LATS (large tumour suppressor) family of kinases represents a subclass of the AGC (protein kinase A (PKA)/PKG/PKC-like) group of serine/threonine protein kinases. Members of the NDR/LATS family are vital components of conserved pathways controlling essential cellular processes, such as proliferation (cell cycle progression) and cell death. In particular, the central involvement of NDR/LATS as YAP/TAZ kinases in the Hippo tissue growth control pathway has gained much interest. In this review, we summarize the roles of mammalian NDR1/2 (aka STK38/STK38L) and LATS1/2 in immunity and cancer biology...
June 1, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28572288/prospective-evaluation-of-changes-in-tumor-size-and-tumor-metabolism-in-patients-with-advanced-gastric-cancer-undergoing-chemotherapy-association-and-clinical-implication
#10
Seongyeol Park, Seunggyun Ha, Hyun Woo Kwon, Woo Hyoung Kim, Tae-Yong Kim, Do-Youn Oh, Gi Jeong Cheon, Yung-Jue Bang
A change in tumor size is a well-validated and commonly used value for evaluating response to chemotherapy in cancer. Metabolic changes induced by chemotherapy are related to prognosis in several tumor types. However, the clinical implication of metabolic changes in patients with advanced gastric cancer (AGC) undergoing chemotherapy remains unclear. We aimed to evaluate response of tumor size and metabolism in AGC during chemotherapy and to reveal the relationship between them in view of their impact on patient survival...
June 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28571764/protein-kinase-c-pkc-isoforms-in-cancer-tumor-promotion-and-tumor-suppression
#11
REVIEW
Noah Isakov
The AGC family of serine/threonine kinases (PKA, PKG, PKC) includes more than 60 members that are critical regulators of numerous cellular functions, including cell cycle and differentiation, morphogenesis, and cell survival and death. Mutation and/or dysregulation of AGC kinases can lead to malignant cell transformation and contribute to the pathogenesis of many human diseases. Members of one subgroup of AGC kinases, the protein kinase C (PKC), have been singled out as critical players in carcinogenesis, following their identification as the intracellular receptors of phorbol esters, which exhibit tumor-promoting activities...
May 29, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28559521/contribution-of-putative-efflux-pump-genes-to-isoniazid-resistance-in-clinical-isolates-of-mycobacterium-tuberculosis
#12
Anshika Narang, Astha Giri, Shraddha Gupta, Kushal Garima, Mridula Bose, Mandira Varma-Basil
BACKGROUND: Isoniazid (INH) resistance in Mycobacterium tuberculosis has been mainly attributed to mutations in katG (64%) and inhA (19%). However, 20%-30% resistance to INH cannot be explained by mutations alone. Hence, other mechanisms besides mutations may play a significant role in providing drug resistance. Here, we explored the role of 24 putative efflux pump genes conferring INH-resistance in M. tuberculosis. MATERIALS AND METHODS: Real-time expression profiling of the efflux pump genes was performed in five INH-susceptible and six high-level INH-resistant clinical isolates of M...
April 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28549032/expression-of-phosphoinositide-3-kinase-p110%C3%AE-and-p110%C3%AE-subunits-and-pik3ca-mutation-in-patients-with-advanced-gastric-carcinoma
#13
Kyungeun Kim, Hyoun Wook Lee
Activation of phosphoinositide 3-kinase (PI3K) is pivotal for the activity of the oncogenic PI3K/AKT signaling pathway. This study assessed the expression of 2 PI3K isoform proteins, p110α and p110β, and PIK3CA mutational status in advanced gastric carcinoma (AGC) and their correlation with clinicopathologic factors. Tissue microarray blocks were generated from 99 AGCs and immunohistochemically stained for p110α and p110β. Analysis of mutations in the PIK3CA gene, which encodes p110α, was performed using the PNAClamp PIK3CA Mutation Detection kit...
May 25, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28538217/the-significance-of-glandular-cells-on-conventional-cervicovaginal-smears-experience-from-a-tertiary-care-hospital-in-coastal-india
#14
Pooja K Suresh, Hema Kini, Jessica Minal, Neha Dhavalpure, Sridevi H Basavaiah, Deepa S Adiga, Laveena Maben
INTRODUCTION: Glandular lesions of the female genital tract (FGT) are quite uncommon compared to squamous lesions. Their cytological diagnosis is difficult because of their architectural and cytological complexity, as well as the lack of experience of many cytopathologists in this field. The aim of this study was to determine the significance of Papanicolaou (Pap) smears in the diagnosis of glandular FGT lesions. METHODOLOGY: All Pap smears reported during the period of January 2012 to December 2013 were retrieved...
2017: Acta Cytologica
https://www.readbyqxmd.com/read/28516322/do-functional-diversity-and-trait-dominance-determine-carbon-storage-in-an-altered-tropical-landscape
#15
Achim Häger, Gerardo Avalos
Altered landscapes play a major role in biodiversity conservation and carbon (C) storage in the tropics. There is increasing evidence that C storage potential is controlled by tree functional diversity, but underlying mechanisms are debated. We analyzed the effects of trait dominance (mass-ratio hypothesis), species diversity, and trait variation (species complementarity) on C storage in the soils and vegetation of 20 agroforestry systems (AFS) and seven forested sites in Costa Rica. AFS consisted of organic and conventional coffee farms and pastures with trees...
June 2017: Oecologia
https://www.readbyqxmd.com/read/28499502/sesamin-encouraging-effects-on-chondrogenic-differentiation-of-human-amniotic-fluid-derived-mesenchymal-stem-cells
#16
Suteera Narakornsak, Sirinda Aungsuchawan, Peeraphan Pothacharoen, Runchana Markmee, Waleephan Tancharoen, Tanongsak Laowanitwattana, Chawapon Thaojamnong, Lamaiporn Peerapapong, Nonglak Boonma, Witoon Tasuya, Junjira Keawdee, Naree Poovachiranon
Worldwide, the most recognized musculoskeletal degenerative disease is osteoarthritis (OA). Sesamin, a major abundant lignan compound present in Sesamun Indicum Linn, has been described for its various pharmacological effects and health benefits. However, the promoting effects of sesamin on chondrogenic differentiation have not yet been observed. Herein, the aim of this study was to investigate the effects of sesamin on cell cytotoxicity and the potent supporting effects on chondrogenic differentiation of human amniotic fluid-derived mesenchymal stem cells (hAF-MSCs)...
May 9, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28497560/untargeted-metabolomic-analysis-of-capsicum-spp-by-gc-ms
#17
Bianca Camargo Aranha, Jessica Fernanda Hoffmann, Rosa Lia Barbieri, Cesar Valmor Rombaldi, Fábio Clasen Chaves
INTRODUCTION: In order to conserve the biodiversity of Capsicum species and find genotypes with potential to be utilised commercially, Embrapa Clima Temperado maintains an active germplasm collection (AGC) that requires characterisation, enabling genotype selection and support for breeding programmes. OBJECTIVE: The objective of this study was to characterise pepper accessions from the Embrapa Clima Temperado AGC and differentiate species based on their metabolic profile using an untargeted metabolomics approach...
May 11, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28493119/co2-sensing-in-fungi-at-the-heart-of-metabolic-signaling
#18
REVIEW
Ronny Martin, Susann Pohlers, Fritz A Mühlschlegel, Oliver Kurzai
Adaptation to the changing environmental CO2 levels is essential for all living cells. In particular, microorganisms colonizing and infecting the human body are exposed to highly variable concentrations, ranging from atmospheric 0.04 to 5% and more in blood and specific host niches. Carbonic anhydrases are highly conserved metalloenzymes that enable fixation of CO2 by its conversion into bicarbonate. This process is not only crucial to ensure the supply of adequate carbon amounts for cellular metabolism, but also contributes to several signaling processes in fungi, including morphology and communication...
May 10, 2017: Current Genetics
https://www.readbyqxmd.com/read/28476062/patient-reported-outcomes-following-single-and-multiple-radius-total-knee-replacement-a-randomized-controlled-trial
#19
Nadeem Mushtaq, Alexander D Liddle, David Isaac, Katherine Dillow, Paul Gill
Although single-radius (SR) designs of total knee replacement (TKR) have theoretical benefits, the clinical advantage conferred by such designs is unknown. The aim of this randomized, controlled study was to compare the short-term clinical outcomes of the two design rationales. A total of 105 knees were randomized to receive either a single radius (Scorpio, Stryker; SR Group) or multiple radius (AGC, Zimmer Biomet; MR group) TKR. Patient-reported outcomes (Oxford Knee Score [OKS] and Knee Society Score [KSS]) were collected at 6 weeks, 6 months, and 1 year following surgery...
May 5, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28473255/inhibition-of-akt-and-other-agc-kinases-a-target-for-clinical-cancer-therapy
#20
REVIEW
Vincent Prêtre, Andreas Wicki
AGC kinases have been identified to contribute to cancer development and progression. Currently, most AGC inhibitors in clinical development are Akt inhibitors such as MK-2206 or GDC-0068, which are known to promote cell growth arrest and to sensitize cancer cells to radiotherapy. Response rates in clinical trials with single agent Akt inhibitors are typically low. The observed adverse events are within the expected limits for compounds inhibiting the PI3K-mTOR axis. Preclinical and early clinical data for combination therapies are accumulating...
May 1, 2017: Seminars in Cancer Biology
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