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https://www.readbyqxmd.com/read/28205060/validation-of-the-jcog-prognostic-index-in-advanced-gastric-cancer-using-individual-patient-data-from-the-spirits-and-g-sox-trials
#1
Daisuke Takahari, Junki Mizusawa, Wasaburo Koizumi, Ichinosuke Hyodo, Narikazu Boku
BACKGROUND: In a phase III study for advanced gastric cancer (AGC), the Japan Clinical Oncology Group (JCOG) 9912 trial, we previously identified the following four prognostic factors-performance status ≥1, number of metastatic sites ≥2, no prior gastrectomy, and abnormal serum alkaline phosphatase levels-and proposed a prognostic index (good risk with 0 or 1 factor, moderate risk with 2 or 3 factors, and poor risk with all 4 factors). To assess the generalizability of this index, we attempted an external validation study using an independent data set...
February 16, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28195150/molecular-dietary-analysis-of-two-sympatric-felids-in-the-mountains-of-southwest-china-biodiversity-hotspot-and-conservation-implications
#2
Mengyin Xiong, Dajun Wang, Hongliang Bu, Xinning Shao, Dan Zhang, Sheng Li, Rongjiang Wang, Meng Yao
Dietary information is lacking in most of small to mid-sized carnivores due to their elusive predatory behaviour and versatile feeding habits. The leopard cat (LPC; Prionailurus bengalensis) and the Asiatic golden cat (AGC; Catopuma temminckii) are two important yet increasingly endangered carnivore species in the temperate mountain forest ecosystem in Southwest China, a global biodiversity hotspot and a significant reservoir of China's endemic species. We investigated the vertebrate prey of the two sympatric felids using faecal DNA and a next-generation sequencing (NGS)/metabarcoding approach...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28187041/laparoscopy-assisted-versus-open-d2-distal-gastrectomy-for-advanced-gastric-cancer-results-from-a-randomized-phase-ii-multicenter-clinical-trial-coact-1001
#3
Young Kyu Park, Hong Man Yoon, Young-Woo Kim, Ji Yeon Park, Keun Won Ryu, Young-Joon Lee, Oh Jeong, Ki Young Yoon, Jun Ho Lee, Sang Eok Lee, Wansik Yu, Sang-Ho Jeong, Taebong Kim, Sohee Kim, Byoung-Ho Nam
OBJECTIVE: This randomized, phase II, multicenter clinical trial was conducted to evaluate the feasibility of laparoscopy-assisted distal gastrectomy (LADG) with D2 lymph node dissection compared with open distal gastrectomy (ODG) for the treatment of advanced gastric cancer (AGC). SUMMARY OF BACKGROUND DATA: D2 lymph node dissection has been accepted as standard treatment for AGC. Although LADG is widely performed in early gastric cancer (EGC), the feasibility of LADG in AGC has not been proven yet...
February 9, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28174486/aneuploidy-of-chromosome-8-in-circulating-tumor-cells-correlates-with-prognosis-in-patients-with-advanced-gastric-cancer
#4
Yilin Li, Xiaotian Zhang, Jifang Gong, Qiyue Zhang, Jing Gao, Yanshuo Cao, Daisy Dandan Wang, Peter Ping Lin, Lin Shen
OBJECTIVE: Previous work indicated that aneuploidy of chromosome 8 in circulating tumor cells (CTCs) correlated with therapeutic efficacy for advanced gastric cancer (AGC) patients. In this follow-up study performed on the same population of AGC patients, we investigated whether and how aneuploidy of chromosome 8 in CTCs correlates with patients' clinical prognosis. METHODS: The prospective study was performed on 31 patients with newly diagnosed AGC. Previously established integrated subtraction enrichment (SE) and immunostaining-fluorescence in situ hybridization (iFISH) platform was applied to identify, enumerate and characterize CTCs...
December 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28163304/predominant-contribution-of-dgk%C3%AE-over-dgk%C3%AE-in-the-control-of-pkc-pdk-1-regulated-functions-in-t-cells
#5
A Ávila-Flores, J Arranz-Nicolás, E Andrada, D Soutar, I Mérida
Diacylglycerol kinase (DGK)-mediated consumption of the diacylglycerol (DAG) generated in response to antigen recognition is an important mechanism to limit T cell function. Targeting DGK activity presents new opportunities for therapeutic manipulation of the immune response, but assessment of individual DGK functions is complex. T cells express two DGK isoforms, DGKα and DGKζ, and there are no isoform-specific inhibitors. Here we used siRNA-mediated gene silencing in human T cells and DGKα- and DGKζ-deficient mice to define DGK isoform-specific regulation of key signaling pathways during T cell activation...
February 6, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28133181/-a-case-of-advanced-gastric-cancer-resected-for-rebleeding-after-palliative-radiotherapy-for-hemostasis
#6
Yusuke Muneoka, Hiroshi Ichikawa, Takashi Ishikawa, Takaaki Hanyu, Yu Sato, Yosuke Kano, Kenji Usui, Takahiro Otani, Mariko Hishiki, Kohei Miura, Masayuki Nagahashi, Jun Sakata, Takashi Kobayashi, Hitoshi Kameyama, Shinichi Kosugi, Toshifumi Wakai
We report a case of advanced gastric cancer(AGC)that was resected for rebleeding after palliative radiotherapy for hemostasis. A 74-year-old man with Stage IV gastric cancer received chemotherapy and achieved stable disease. After 23 months, he experienced continuous bleeding from the tumor due to regrowth. Palliative radiotherapy was conducted to control the bleeding, and the tumor successfully achieved hemostasis. However, 6 weeks later, the patient experienced rebleeding and developed hemostatic shock. We then performed a successful emergency gastrectomy...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28132088/long-term-outcome-after-laparoscopic-gastrectomy-a-multicenter-retrospective-study
#7
Hiroshi Kawase, Yuma Ebihara, Toshiaki Shichinohe, Fumitaka Nakamura, Katsuhiko Murakawa, Takayuki Morita, Shunichi Okushiba, Satoshi Hirano
BACKGROUND: Despite its spread and advances, laparoscopic gastrectomy (LG) for advanced gastric cancer (AGC) remains controversial. The aim of this study was to evaluate the oncologic outcomes and to identify the potential risk factors for recurrence and survival after LG in AGC patients. PATIENTS AND METHODS: The medical records of patients who underwent radical LG for histopathologically diagnosed stage IB or more advanced gastric cancer from 2004 to 2012 were collected...
January 29, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28131714/indolyl-naphthyl-maleimides-as-potent-and-selective-inhibitors-of-protein-kinase-c-%C3%AE-%C3%AE
#8
Maurice J van Eis, JeanPierre Evenou, Walter Schuler, Gerhard Zenke, Eric Vangrevelinghe, Juergen Wagner, Peter von Matt
The indolyl-naphthyl maleimide 7 is a potent inhibitor of the classical PKC isotypes α,β and shows excellent selectivity over the novel PKC isotypes δ,ε,η,θ and other kinases belonging to the AGC family. The SAR around 7 as well as the physico-chemical characteristics of selected derivatives and their activity in T and B cell activation and proliferation assays are discussed.
January 16, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28117472/association-between-severe-asthma-and-changes-in-the-stomatognathic-system
#9
Mayra Carvalho-Oliveira, Cristina Salles, Regina Terse, Argemiro D'Oliveira
Objective: To describe orofacial muscle function in patients with severe asthma. Methods: This was a descriptive study comparing patients with severe controlled asthma (SCA) and severe uncontrolled asthma (SUA). We selected 160 patients, who completed a sociodemographic questionnaire and the 6-item Asthma Control Questionnaire (ACQ-6), as well as undergoing evaluation of orofacial muscle function. Results: Of the 160 patients evaluated, 126 (78...
November 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/28108419/regulation-of-protein-kinase-c-related-kinase-prk-signalling-by-the-tp%C3%AE-and-tp%C3%AE-isoforms-of-the-human-thromboxane-a2-receptor-implications-for-thromboxane-and-androgen-dependent-neoplastic-and-epigenetic-responses-in-prostate-cancer
#10
Aine G O'Sullivan, Eamon P Mulvaney, B Therese Kinsella
The prostanoid thromboxane (TX) A2 and its T Prostanoid receptor (the TP) are increasingly implicated in prostate cancer (PCa). Mechanistically, we recently discovered that both TPα and TPβ form functional signalling complexes with members of the protein kinase C-related kinase (PRK) family, AGC- kinases essential for the epigenetic regulation of androgen receptor (AR)-dependent transcription and promising therapeutic targets for treatment of castrate-resistant prostate cancer (CRPC). Critically, similar to androgens, activation of the PRKs through the TXA2/TP signalling axis induces phosphorylation of histone H3 at Thr11 (H3Thr11), a marker of androgen-induced chromatin remodelling and transcriptional activation, raising the possibility that TXA2-TP signalling can mimic and/or enhance AR-induced cellular changes even in the absence of circulating androgens such as in CRPC...
January 18, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28102709/weight-loss-during-initial-chemotherapy-predicts-survival-in-patients-with-advanced-gastric-cancer
#11
Kotoe Takayoshi, Keita Uchino, Masahiro Nakano, Koji Ikejiri, Eishi Baba
BACKGROUND: Patients with advanced gastric cancer (AGC) often suffer weight loss, which can be used to predict prognosis. Few reports have assessed the correlation between weight loss during chemotherapy and survival in patients with AGC. METHODS: Fifty-three patients with histologically proven AGC, who started systemic chemotherapy from September 2010 to March 2014, were retrospectively examined for body weight, inflammatory status, and survival. Correlation analyses were performed between weight change and survival...
January 19, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28100301/high-throughput-screening-of-a-glaxosmithkline-protein-kinase-inhibitor-set-identifies-an-inhibitor-of-human-cytomegalovirus-replication-that-prevents-creb-and-histone-h3-post-translational-modification
#12
Amina S Khan, Matthew J Murray, Catherine M K Ho, William J Zuercher, Matthew B Reeves, Blair L Strang
To identify new compounds with anti-human cytomegalovirus (HCMV) activity and new anti-HCMV targets, we developed a high throughput strategy to screen a GlaxoSmithKline (GSK) Published Kinase Inhibitor Set (PKIS). This collection contains a range of extensively characterized compounds grouped into chemical families (chemotypes). From our screen we identified compounds within chemotypes that impede HCMV replication and identified kinase proteins associated with inhibition of HCMV replication that are potential novel anti-HCMV targets...
January 18, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28074308/influence-of-ts-and-abcb1%C3%A2-gene-polymorphisms-on-survival-outcomes-of-5%C3%A2-fu-based-chemotherapy-in-a%C3%A2-chinese-population-of-advanced-gastric-cancer-patients
#13
Jun Chen, Xueming Ying, Ling Zhang, Xiaojun Xiang, Jianping Xiong
To investigate the impacts of gene variations on survival outcomes of advanced gastric cancer (AGC) patients treated with 5‑fluorouracil (5-FU)-based chemotherapy, we analyzed the associations of 2 indels of the TS gene rs34743033 (double or triple tandem repeats of a 28 bp sequence in 5'-UTR, denoted as 2R or 3R allele) and rs16430 (a 6 bp variation at 1494 bp in 3'-UTR, denoted as ins6 or del6 allele) and 2 single nucleotide polymorphisms (SNPs) of ABCB1gene rs2032582 in exon 21 and rs1045642 in exon 26, with clinical outcomes after 5‑FU treatment...
January 10, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28060456/significance-of-high-risk-hpv-detection-in-women-with-atypical-glandular-cells-on-pap-testing-analysis-of-1857-cases-from-an-academic-institution
#14
Stell Patadji, Zaibo Li, Dinesh Pradhan, Chengquan Zhao
BACKGROUND: The role of high-risk human papillomavirus (hrHPV) testing in women with various types of atypical glandular cells (AGC) on Papanicolaou (Pap) test is undetermined. METHODS: Herein, the authors retrospectively searched their pathology database for cases of AGC with concurrent hrHPV testing and histological follow-up results within 1 year between January 2008 and December 2013. RESULTS: Among 3709 AGC cases occurring during the study period, 2287 had concurrent Hybrid Capture 2 HPV testing results...
October 24, 2016: Cancer
https://www.readbyqxmd.com/read/28045490/an-allosteric-inhibitor-scaffold-targeting-the-pif-pocket-of-atypical-protein-kinase-c-isoforms
#15
Jose M Arencibia, Wolfgang Fröhner, Magdalena Krupa, Daniel Pastor-Flores, Piotr Merker, Thomas Oellerich, Sonja Neimanis, Christian Schmithals, Verena Köberle, Evelyn Süß, Stefan Zeuzem, Holger Stark, Albrecht Piiper, Dalibor Odadzic, Jörg O Schulze, Ricardo M Biondi
There is a current and pressing need for improved cancer therapies. The use of small molecule kinase inhibitors and their application in combinatorial regimens represent an approach to personalized targeted cancer therapy. A number of AGC kinases, including atypical Protein Kinase C enzymes (PKCs), are validated drug targets for cancer treatment. Most drug development programs for protein kinases focus on the development of drugs that bind at the ATP-binding site. Alternatively, allosteric drugs have great potential for the development of future innovative drugs...
January 13, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28033156/tubulopapillary-cystic-adenoma-with-apocrine-differentiation-a-unifying-concept-for-syringocystadenoma-papilliferum-apocrine-gland-cyst-and-tubular-papillary-adenoma
#16
Shin-Ichi Ansai, Takashi Anan, Takaya Fukumoto, Hidehisa Saeki
Syringocystadenoma papilliferum (SCAP), apocrine gland cyst (AGC, also called apocrine hidrocystoma or apocrine cystadenoma), and tubular papillary adenoma (TPA) with apocrine differentiation are defined as proliferations of apocrine epithelium with myoepithelial cells. At Sapporo Dermatopathology Institute, we retrieved 308 benign neoplastic lesions diagnosed as SCAP, AGC, or TPA and combinations of these entities. Among the 308 lesions, 202 (66%) exhibited features of only one type, of which 144 (47%) were AGC, 39 (13%) were TPA, and 19 (6%) were SCAP...
December 28, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28028296/human-papillomavirus-hpv-in-egyptian-females-study-by-cytology-histopathology-colposcopy-and-molecular-diagnosis-of-high-risk-types
#17
M A Nayel, O G Shaker, A N Hosni, H N Hosni, S E Khalifa, A F Shazly
OBJECTIVES: In Northern Africa, the region Egypt belongs to, about 10.7% of women are estimated to harbour cervical human papillomavirus (HPV) infection and 78.4% of invasive cancers are attributed to HPVs 16 or 18. We aimed at comparing HPV detection by ISH-PCR tissue with other conventional available cheaper techniques, finding which of them can be relied upon in a developing country like Egypt for HPV detection. METHODS: Sixty patients were included. For them colposcopy, PAP smear, histopathology and detection of HPV using ISH PCR tissue and PCR swab were achieved...
December 2016: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28011507/platinum-based-doublet-chemotherapy-for-advanced-gastric-cancer-with-disseminated-intravascular-coagulation
#18
Keiji Sugiyama, Yukiya Narita, Shigenori Kadowaki, Takashi Ura, Masahiro Tajika, Kei Muro
BACKGROUND: Disseminated intravascular coagulation (DIC) is a rare complication of advanced gastric cancer (AGC). Despite reports of the efficacy of chemotherapy for AGC with DIC, little is known of platinum-based doublet therapy. PATIENTS AND METHODS: We conducted a single-institute, retrospective chart review of 500 consecutive chemotherapy-naïve patients with advanced gastric adenocarcinoma (recurrent or metastatic) from November 2010 to November 2015. RESULTS: Six patients were diagnosed with AGC with DIC (1...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28011176/alkyl-substituted-phenylamino-derivatives-of-7-nitrobenz-2-oxa-1-3-diazole-as-uncouplers-of-oxidative-phosphorylation-and-antibacterial-agents-involvement-of-membrane-proteins-in-the-uncoupling-action
#19
Yuri N Antonenko, Stepan S Denisov, Ljudmila S Khailova, Pavel A Nazarov, Tatyana Rokitskaya, Vadim N Tashlitsky, Alexander M Firsov, Galina A Korshunova, Elena A Kotova
In search for new effective uncouplers of oxidative phosphorylation, we studied 4-aryl amino derivatives of a fluorescent group 7-nitrobenz-2-oxa-1,3-diazol (NBD). In our recent work (Denisov et al., Bioelectrochemistry, 2014), NBD-conjugated alkyl amines (NBD-Cn) were shown to exhibit uncoupling activity. It was concluded that despite a pKa value being about 10, the expected hindering of the uncoupling activity could be overcome by insertion of an alkyl chain. There is evidence in the literature that the introduction of an aryl substituent in the 4-amino NBD group shifts the pKa to neutral values...
December 21, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28000200/-efficacy-and-safety-of-surgery-combined-with-hyperthermic-intraperitoneal-chemotherapy-in-the-treatment-of-advanced-gastric-cancer-a-meta-analysis
#20
Zhentian Ni, Chen Li, Chao Yan, Wentao Liu, Xuexin Yao, Mingmin Chen, Min Yan, Zhenggang Zhu
OBJECTIVE: To systematically evaluate the efficacy and safety of surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of advanced gastric cancer (AGC). METHODS: Clinical control trials about the efficacy and safety of surgery combined with HIPEC in the treatment of advanced gastric cancer published before June 2014 were searched in Embase, PubMed, Cochrane Library, Wanfang database and CNKI database. Quality of enrolled articles was evaluated with the guidelines from Cochrane collaborative network...
December 25, 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
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