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https://www.readbyqxmd.com/read/28739659/the-stress-sensing-torc2-complex-activates-yeast-agc-family-protein-kinase-ypk1-at-multiple-novel-sites
#1
Kristin L Leskoske, Françoise M Roelants, Maria Nieves Martinez Marshall, Jennifer M Hill, Jeremy Thorner
Yeast (Saccharomyces cerevisiae) Target of Rapamycin (TOR) Complex 2 (TORC2) is a multi-subunit plasma membrane-associated protein kinase and vital growth regulator. Its essential functions are exerted via phosphorylation and stimulation of downstream protein kinase Ypk1 (and its paralog Ypk2). Ypk1 phosphorylates multiple substrates to regulate plasma membrane lipid and protein composition. Ypk1 function requires phosphorylation of Thr504 in its activation loop by eisosome-associated Pkh1 (and its paralog Pkh2)...
July 24, 2017: Genetics
https://www.readbyqxmd.com/read/28730292/efficacy-and-safety-of-taxane-monotherapy-in-advanced-gastric-cancer-refractory-to-triplet-chemotherapy-with-docetaxel-cisplatin-and-s-1-a-multicenter-retrospective-study
#2
Sakura Iizumi, Atsuo Takashima, Yukiya Narita, Masahiro Tajika, Kei Muro, Sadayuki Kawai, Hirofumi Yasui, Tomohiro Matsushima, Daisuke Takahari, Kengo Nagashima, Narikazu Boku
PURPOSE: Taxane monotherapy is widely used for advanced gastric cancer (AGC) after failure of standard first-line chemotherapy with fluoropyrimidine and cisplatin. Triplet chemotherapy with docetaxel, cisplatin, and S-1 (DCS) is a promising regimen for first-line chemotherapy of AGC. The aim of this study was to evaluate the efficacy of taxane monotherapy in patients refractory to DCS. METHODS: We retrospectively evaluated the efficacy and safety of taxane monotherapy in patients with AGC refractory to first-line therapy with DCS between January 2010 and April 2015...
July 20, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28726137/long-and-short-term-outcomes-of-laparoscopic-gastrectomy-versus-open-gastrectomy-in-patients-with-clinically-and-pathological-locally-advanced-gastric-cancer-a-propensity-score-matching-analysis
#3
Mikito Inokuchi, Masatoshi Nakagawa, Toshiro Tanioka, Keisuke Okuno, Kentaro Gokita, Kazuyuki Kojima
BACKGROUND: Laparoscopic (laparoscopy-assisted) gastrectomy (LG) has several short-term benefits as compared with open distal gastrectomy (OG) in patients with advanced gastric cancer (AGC). Survival rates did not differ significantly between LG and OG in retrospective studies of AGC, although some studies included unmatched groups of patients or patients with AGC who had a preoperative diagnosis of early gastric cancer. The aim of present study was to compare the short- and long-term outcomes of patients with AGC who underwent LG with those of patients with AGC who underwent OG using a propensity-score matching analysis...
July 19, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28725419/tree-species-diversity-promotes-aboveground-carbon-storage-through-functional-diversity-and-functional-dominance
#4
Sylvanus Mensah, Ruan Veldtman, Achille E Assogbadjo, Romain Glèlè Kakaï, Thomas Seifert
The relationship between biodiversity and ecosystem function has increasingly been debated as the cornerstone of the processes behind ecosystem services delivery. Experimental and natural field-based studies have come up with nonconsistent patterns of biodiversity-ecosystem function, supporting either niche complementarity or selection effects hypothesis. Here, we used aboveground carbon (AGC) storage as proxy for ecosystem function in a South African mistbelt forest, and analyzed its relationship with species diversity, through functional diversity and functional dominance...
October 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28722080/-a-surgery-oriented-classification-in-conversion-therapy-of-gastric-cancer
#5
Ziyu Li, Kan Xue, Jiafu Ji
Clinical practice showed that some advanced gastric cancer (AGC) patients achieved long-term survival after surgery, whereas some benefited from non-surgical treatment. In recent years, with the emergence of new drugs, diversity of treatment and development of multi-disciplinary team, the concept of conversion therapy comes into attention. Owing to diverse phenotypes with scattered cases, publications are mainly case reports or small sample studies from single centers, which makes it hard to acquire high-level evidence...
July 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28722075/a-new-route-for-the-synthesis-of-a-ag-nanopore-inlay-nanogap-structure-integrated-ag-core-graphene-shell-ag-jacket-nanoparticles-for-high-efficiency-sers-detection
#6
Hengwei Qiu, Minqiang Wang, Zhi Yang, Shouzhen Jiang, Yanjun Liu, Le Li, Minghui Cao, Junjie Li
We present a new route for the synthesis of Ag nanopore-inlay-nanogap structures using creviced graphene-shell encapsulated Cu nanoparticles (Cu@G-NPs) as the sacrificial templates. The as-synthesized integrated Ag-core@graphene-shell@Ag-jacket nanoparticles (AgC@G@AgJ-NPs) presents "chrysanthemum" shapes that contain abundant sub-10 nm size intraparticle nanopores/nanogaps, which can generate huge enhanced electromagnetic fields to support SERS activity, resulting in an average EF > 10(7) due to a high-density of intraparticle and interparticle "hot spots"...
July 19, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28712702/clinical-usefulness-of-f-18-fdg-pet-in-lymphoepithelioma-like-gastric-carcinoma
#7
Soyeon Park, Dakeun Lee, Kee Myung Lee, Sang-Uk Han, Jei Hee Lee, Su Jin Lee, Young-Sil An, Joon-Kee Yoon
PURPOSE: Lymphoepithelioma-like carcinoma (LELC) is a rare type of gastric cancer. We evaluated the clinical usefulness of F-18 FDG positron emission tomography/computed tomography (PET/CT) in LELC of stomach. MATERIALS AND METHODS: A total of 28 patients (mean age=59years) who underwent preoperative F-18 FDG PET/CT were enrolled retrospectively. Nine patients underwent follow-up F-18 FDG PET/CT. Pathologic information was obtained through gastrectomy and the association with Epstein-Barr virus (EBV) was investigated in 26 patients...
June 27, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28709491/band-pattern-analysis-of-mutations-in-rifampicin-resistance-strain-of-mycobacterium-tuberculosis-by-line-probe-assay-in-patients-from-delhi-india
#8
Himanshu Vashistha, M Hanif, K K Chopra, Ashwani Khanna, Divya Shrivastava
BACKGROUND: The GenoType MTBDRplus, a commercial Line Probe Assay (LPA) kit from Hain Lifescience, Germany, is endorsed by India's RNTCP Program for diagnosis of DRTB cases among smear-positive sputum samples. Although the LPA has been studied in several laboratories, there is a wide variation in existing M. tuberculosis strains across the globe, and false results can occur due to the presence of unique genetic mutations in different settings. AIM AND OBJECTIVE: An attempt was made to carry out band pattern analysis using LPA and also to observe uncommon mutations in MDR strains...
July 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28706257/efficacy-and-safety-of-taxane-based-systemic-chemotherapy-of-advanced-gastric-cancer-a-systematic-review-and-meta-analysis
#9
Jinxin Shi, Peng Gao, Yongxi Song, Xiaowan Chen, Yuan Li, Changwang Zhang, Hongchi Wang, Zhenning Wang
Taxanes are chemotherapeutic agents commonly used to treat several cancers. However, the effects of taxanes on advanced gastric cancer (AGC) are still not clear, especially when used as a first-line treatment. This systematic review and meta-analysis aims to investigate the efficacy and safety of taxanes as a first-line treatment of AGC. The quality of our included studies was assessed using the Cochrane risk of bias tool for RCTs and NOS scale for nRCTs, and the data of the included studies was of satisfactory quality to analyze...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28701892/a-pilot-study-of-post-operative-adjuvant-vaccine-for-advanced-gastric-cancer
#10
Yoshiyuki Fujiwara, Keijiro Sugimura, Hiroshi Miyata, Takeshi Omori, Hiroyuki Nakano, Chie Mochizuki, Katsuji Shimizu, Hiroaki Saito, Keigo Ashida, Soichiro Honjyo, Yusuke Nakamura, Masahiko Yano
BACKGROUND: Previously, we had performed a clinical study using human leukocyte antigen (HLA)-A24-binding peptide vaccines containing a combination of novel cancer-testis antigens and anti-angiogenic peptides derived from DEPDC1, URLC10, FOXM1, KIF20A and VEGFR1 for advanced gastric cancer (AGC) patients who were refractory to chemotherapy. We applied the cocktail vaccine to the combination therapy with S-1 for patients with AGC as a post-operative adjuvant therapy and performed this clinical pilot study...
June 2017: Yonago Acta Medica
https://www.readbyqxmd.com/read/28697579/can-low-dose-ct-perfusion-imaging-accurately-assess-response-of-advanced-gastric-cancer-with-neoadjuvant-chemotherapy
#11
Zong-Qiong Sun, Gen Yan, Yu-Xi Ge, Jie Li, Lin-Fang Jin, Zhi-Hui Xie, Peng Zhao
PURPOSE: To explore the value of low-dose CT perfusion imaging (LDCTPI) technology and its perfusion parameters in assessing response of neoadjuvant chemotherapy (NAC) in patients with advanced gastric cancer (AGC). METHODS: Thirty patients with AGC were studied prospectively by LDCTPI to measure two parameters including blood flow (BF) and blood volume (BV) of tumor area before and after chemotherapy, respectively. All of the patients received two courses of NAC and surgical resection of gastric tumor within one week after chemotherapy, and then obtained the result of postoperative pathology response for chemotherapy...
July 7, 2017: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/28694518/pdk1-plays-a-vital-role-on-hematopoietic-stem-cell-function
#12
Tianyuan Hu, Cong Li, Le Wang, Yingchi Zhang, Luyun Peng, Hui Cheng, Yajing Chu, Weili Wang, Hideo Ema, Yingdai Gao, Zhenyu Ju, Zhongzhou Yang, Xiaomin Wang, Tao Cheng, Weiping Yuan
3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a pivotal regulator in the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway that have been shown to play key roles in the functional development of B and T cells via activation of AGC protein kinases during hematopoiesis. However, the role of PDK1 in HSCs has not been fully defined. Here we specifically deleted the PDK1 gene in the hematopoietic system and found that PDK1-deficient HSCs exhibited impaired function and defective lineage commitment abilities...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28694503/cd44v8-10-as-a-potential-theranostic-biomarker-for-targeting-disseminated-cancer-cells-in-advanced-gastric-cancer
#13
Eun-Seok Choi, Hyunjin Kim, Hyung-Pyo Kim, Yongdoo Choi, Sung-Ho Goh
Gastric cancer is the third most common cause of cancer mortality, and the survival rate of stage IV advanced gastric cancer (AGC) patients with distant metastasis is very low. Thus, the detection and eradication of disseminated cancer cells by targeting cell surface molecules in AGC would improve patient survival. The hyaluronic acid receptor, CD44, has various isoforms generated by alternative splicing, and some isoforms are known to be correlated to gastric cancer. In this study, to find out the most appropriate CD44v for targeting AGC, we analysed the expression differences of CD44 isoforms at the mRNA level in stomach cancer cell lines as well as in 74 patients with AGC by using exon-specific qRT-PCR...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28688646/laparoscopic-versus-open-gastrectomy-for-gastric-cancer-with-serous-invasion-long-term-outcomes
#14
Yonggang Xu, Jin Hua, Jipeng Li, Liubin Shi, Jie Yuan, Jianjun Du
BACKGROUND: Laparoscopy-assisted gastrectomy (LAG) has already been introduced for advanced gastric cancer (AGC). However, little is known as to whether LAG is also applicable for AGC with serous invasion given the possibility that malignant cell dissemination and local recurrence incidence might increase. This study was designed to evaluate the technical feasibility and oncological adequacy of LAG in comparison with open gastrectomy (OG) for AGC with serous invasion. METHODS: A retrospective case-matched study was conducted to compare LAG and OG for AGC with serous invasion...
July 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28687001/clinical-efficacy-of-neoadjuvant-chemotherapy-regimens-fleeox-vs-xelox-in-patients-with-initially-unresectable-advanced-gastric-cancer-a-propensity-score-analysis
#15
Yang Li, Jun Chen, Qi He, Xiang Ji, Xulin Wang, Chaogang Fan, Guoli Li
PURPOSE: This study was designed to assess the effectiveness of FLEEOX (5-Fu, leucovorin, etoposide, oxaliplatin, and epirubicin) compared with XELOX (capecitabine and oxaliplatin) as neoadjuvant chemotherapy (NAC) for initially unresectable advanced gastric cancer (AGC). METHODS: This study reviewed patients who underwent FLEEOX or XELOX for initially unresectable AGC. To reduce the bias in patient selection, we conducted propensity score match (PSM) with 1:1 ratio...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28680955/second-line-treatments-for-advanced-gastric-cancer-a-network-meta-analysis-of-overall-survival-using-parametric-modelling-methods
#16
Rebecca C Harvey
INTRODUCTION: Advanced gastric cancer (AGC) is one of the most common forms of cancer and remains difficult to cure. There is currently no recommended therapy for second-line AGC in the UK despite the availability of various interventions. This paper aims to compare different interventions for treatment of second-line AGC using more complex methods to estimate relative efficacy, fitting various parametric models and to compare results to those published adopting conventional methods of synthesis...
2017: Oncology and Therapy
https://www.readbyqxmd.com/read/28676627/sorghum-dw2-encodes-a-protein-kinase-regulator-of-stem-internode-length
#17
Josie L Hilley, Brock D Weers, Sandra K Truong, Ryan F McCormick, Ashley J Mattison, Brian A McKinley, Daryl T Morishige, John E Mullet
Sorghum is an important C4 grass crop grown for grain, forage, sugar, and bioenergy production. While tall, late flowering landraces are commonly grown in Africa, short early flowering varieties were selected in US grain sorghum breeding programs to reduce lodging and to facilitate machine harvesting. Four loci have been identified that affect stem length (Dw1-Dw4). Subsequent research showed that Dw3 encodes an ABCB1 auxin transporter and Dw1 encodes a highly conserved protein involved in the regulation of cell proliferation...
July 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28669343/pharmacoinformatic-approaches-to-design-novel-inhibitors-of-protein-kinase-b-pathways-in-cancer
#18
Noreen Akhtar, Ishrat Jabeen
BACKGROUND: Protein kinase B (PKB/Akt) belongs to the AGC superfamily of related serine/threonine kinases with three structurally homologous mammalian isoforms, Akt1 (PKBα), Akt2 (PKBβ), and Akt3 (PKBγ). Various immunohistochemical studies have reported that the constitutive hyperactivation of Akt signaling is responsible for several types of human cancers. Thus, inhibition of Akt activation represents a promising concept to induce cell apoptosis in various cancers. However, till date none of them could reach the market for routine clinical usage to circumvent cell proliferation in cancer due to lack of isoform selectivity and off-target toxicity...
June 23, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/28659723/helitrons-and-retrotransposons-are-co-localized-in-bos-taurus-genomes
#19
A Babii, S Kovalchuk, T Glazko, G Kosovsky, V Glazko
BACKGROUND: DNA transposons helitrons are mobile genetic elements responsible for major movements of the genetic material within and across different genomes. This ability makes helitrons suitable candidate elements for the development of new approaches of multilocus genotyping of live-stock animals, along with the well-known microsatellite loci. OBJECTIVE: We aimed to estimate the informativeness of helitron and microsatellite markers in assessing the consolidation and the "gene pool" standards of two commercial dairy cattle breeds (Ayrshire breed and holsteinized Black-and-White cattle) and one local breed of Kalmyk cattle, and to reveal any inter-breed difference in the organization of genomic regions flanked by helitrons in the studied cattle breeds...
June 2017: Current Genomics
https://www.readbyqxmd.com/read/28650730/yield-of-staging-laparoscopy-for-incurable-factors-in-chinese-patients-with-advanced-gastric-cancer
#20
Jun Huang, Hongliang Luo, Chengliang Zhou, Jianjun Zhan, Xionghui Rao, Gang Zhao, Zhengming Zhu
BACKGROUND: Although the role of staging laparoscopy (SL) in detecting radiologically occult M1 disease has been widely recognized, it is seldom used in China and its clinical value based on Chinese population has been rarely reported. The aim of this study is to identify the yield of SL for Chinese patients with advanced gastric cancer (AGC) and determine the proportions of patients in whom treatment plan is altered. MATERIALS AND METHODS: The clinical data were retrospectively collected from 879 AGC patients who underwent SL without any definite signs of disseminated disease on imaging examination...
June 26, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
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