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https://www.readbyqxmd.com/read/28339539/unique-aggregation-of-conjugated-amphotericin-b-and-its-interaction-with-lipid-membranes
#1
Sarah Kagan, Diana E Ickowicz, Abraham J Domb, Arie Dagan, Itzhack Polacheck
The purpose of this paper was to investigate the aggregation of amphotericin B (AMB) and AMB-arabinogalactan conjugate (AMB-AGC), and the interactions of these drugs with free and membrane-embedded sterols. Aggregation of AMB and AMB-AGC was studied by circular dichroic (CD) and UV absorbance spectroscopic techniques. The effect of liposomes on the spectra was utilized to investigate the interactions of aggregates with membrane-embedded sterols. Interaction with free sterols was studied by measuring sterols' effect on AMB/AMB-AGC susceptibility test...
October 7, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28335576/genome-wide-identification-and-evolutionary-analysis-of-sarcocystis-neurona-protein-kinases
#2
Edwin K Murungi, Henry M Kariithi
The apicomplexan parasite Sarcocystis neurona causes equine protozoal myeloencephalitis (EPM), a degenerative neurological disease of horses. Due to its host range expansion, S. neurona is an emerging threat that requires close monitoring. In apicomplexans, protein kinases (PKs) have been implicated in a myriad of critical functions, such as host cell invasion, cell cycle progression and host immune response evasion. Here, we used various bioinformatics methods to define the kinome of S. neurona and phylogenetic relatedness of its PKs to other apicomplexans...
March 21, 2017: Pathogens
https://www.readbyqxmd.com/read/28303362/phase-i-ii-study-of-a-combination-of-capecitabine-cisplatin-and-intraperitoneal-docetaxel-xp-id-in-advanced-gastric-cancer-patients-with-peritoneal-metastasis
#3
Hyungwoo Cho, Min-Hee Ryu, Kyu-Pyo Kim, Baek-Yeol Ryoo, Sook Ryun Park, Bum Soo Kim, In-Seob Lee, Hee-Sung Kim, Moon-Won Yoo, Jeong Hwan Yook, Seong Tae Oh, Byung Sik Kim, Yoon-Koo Kang
BACKGROUND: This study was conducted to determine the recommended dose (RD) of intraperitoneal docetaxel (ID) in combination with systemic capecitabine and cisplatin (XP) and to evaluate its efficacy and safety at the RD in advanced gastric cancer (AGC) patients with peritoneal metastasis. METHODS: AGC patients with peritoneal metastasis received XP ID, which consists of 937.5 mg/m(2) of capecitabine twice daily on days 1-14, 60 mg/m(2) of intravenous cisplatin on day 1, and intraperitoneal docetaxel at 3 different dose levels (60, 80, or 100 mg/m(2)) on day 1, every 3 weeks...
March 16, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28287465/serine-threonine-kinase-3-phosphoinositide-dependent-protein-kinase-1-pdk1-as-a-key-regulator-of-cell-migration-and-cancer-dissemination
#4
REVIEW
Laura Di Blasio, Paolo A Gagliardi, Alberto Puliafito, Luca Primo
Dissecting the cellular signaling that governs the motility of eukaryotic cells is one of the fundamental tasks of modern cell biology, not only because of the large number of physiological processes in which cell migration is crucial, but even more so because of the pathological ones, in particular tumor invasion and metastasis. Cell migration requires the coordination of at least four major processes: polarization of intracellular signaling, regulation of the actin cytoskeleton and membrane extension, focal adhesion and integrin signaling and contractile forces generation and rear retraction...
March 11, 2017: Cancers
https://www.readbyqxmd.com/read/28277030/cost-minimization-analysis-of-capecitabine-versus-5-fluorouracil-based-treatment-for-gastric-cancer-patients-in-hong-kong
#5
Keary R Zhou, Ashley Cheng, W T Ng, T Y Kwok, Elton Y P Yip, Rosa Yao, P Y Leung, V W Y Lee
BACKGROUND: EOX (epirubicin, oxaliplatin, Xeloda; capecitabine) and FOLFOX4 (5-fluorouracil (5-FU), leucovorin, oxaliplatin) are the common chemotherapy regimens used in the treatment of advanced gastric cancer (aGC) in Hong Kong. This study aimed to compare the costs of these therapies for aGC patients from both the healthcare and societal perspectives. It should be noted that, while FOLFOX4 is routinely administered in an outpatient setting in North America and Europe, inpatient setting is adopted in Hong Kong instead, incurring hospitalization cost as a result...
March 2, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28269324/a-simulation-analysis-of-the-variability-of-the-roving-level-hearing-test
#6
Greg D Watkins, Brett A Swanson, Gregg J Suaning
In the study of auditory prostheses, the Speech Recognition Threshold (SRT) is the Signal to Noise Ratio (SNR) at which 50% of words are correctly identified. SRT is typically measured using an adaptive procedure wherein speech is presented at a fixed sound pressure level (SPL) and the noise level is varied according to the subject's responses. A roving level SRT test has been used by researchers with the goal of including the effectiveness of Automatic Gain Control (AGC) systems in SRT measurements. The roving method presents speech at three different SPLs with the level for each sentence chosen pseudo-randomly, while adaptively varying the SNR...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269120/automated-embolic-signal-detection-using-adaptive-gain-control-and-classification-using-anfis
#7
Praotasna Sombune, Phongphan Phienphanich, Sombat Muengtaweepongsa, Anuchit Ruamthanthong, Charturong Tantibundhit
This work proposes an automated system for real-time high-accuracy detection of cerebral embolic signals (ES) to couple with transcranial Doppler ultrasound (TCD) devices in diagnosing a risk of stroke. The algorithm employs Adaptive Gain Control (AGC) approach to capture suspected ESs in real-time. Then, Adaptive Wavelet Packet Transform (AWPT) and Fast Fourier Transform (FFT) are used to extract from them features most efficiently representing ES, which determined by Sequential Feature Selection technique...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268701/dual-mode-cmos-analog-front-end-afe-for-electrical-impedance-spectroscopy-eis-systems
#8
Virgilio Valente, Dai Jiang, Andreas Demosthenous
This paper presents the operation of a dual-mode wideband CMOS analog front-end (AFE) for electrical impedance spectroscopy. The chip combines two current-readout (CR) channels and four voltage-readout (VR) channels suitable for both bipolar and tetrapolar EIS analysis. The chip addresses the need for flexible readout units for real-time simultaneous single-cell and large scale tissue/organ analysis. Postlayout simulations show that the VR channel is capable of wideband operation up to 12 MHz with noise floor as low as 16...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28264193/substrate-specificity-of-tor-complex-2-is-determined-by-a-ubiquitin-fold-domain-of-the-sin1-subunit
#9
Hisashi Tatebe, Shinichi Murayama, Toshiya Yonekura, Tomoyuki Hatano, David Richter, Tomomi Furuya, Saori Kataoka, Kyoko Furuita, Chojiro Kojima, Kazuhiro Shiozaki
The target of rapamycin (TOR) protein kinase forms multi-subunit TOR complex 1 (TORC1) and TOR complex 2 (TORC2), which exhibit distinct substrate specificities. Sin1 is one of the TORC2-specific subunit essential for phosphorylation and activation of certain AGC-family kinases. Here, we show that Sin1 is dispensable for the catalytic activity of TORC2, but its conserved region in the middle (Sin1CRIM) forms a discrete domain that specifically binds the TORC2 substrate kinases. Sin1CRIM fused to a different TORC2 subunit can recruit the TORC2 substrate Gad8 for phosphorylation even in the sin1 null mutant of fission yeast...
March 7, 2017: ELife
https://www.readbyqxmd.com/read/28227565/a-simulation-analysis-of-the-variability-of-the-roving-level-hearing-test
#10
Greg D Watkins, Brett A Swanson, Gregg J Suaning, Greg D Watkins, Brett A Swanson, Gregg J Suaning, Greg D Watkins, Brett A Swanson, Gregg J Suaning
In the study of auditory prostheses, the Speech Recognition Threshold (SRT) is the Signal to Noise Ratio (SNR) at which 50% of words are correctly identified. SRT is typically measured using an adaptive procedure wherein speech is presented at a fixed sound pressure level (SPL) and the noise level is varied according to the subject's responses. A roving level SRT test has been used by researchers with the goal of including the effectiveness of Automatic Gain Control (AGC) systems in SRT measurements. The roving method presents speech at three different SPLs with the level for each sentence chosen pseudo-randomly, while adaptively varying the SNR...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227349/automated-embolic-signal-detection-using-adaptive-gain-control-and-classification-using-anfis
#11
Praotasna Sombune, Phongphan Phienphanich, Sombat Muengtaweepongsa, Anuchit Ruamthanthong, Charturong Tantibundhit, Praotasna Sombune, Phongphan Phienphanich, Sombat Muengtaweepongsa, Anuchit Ruamthanthong, Charturong Tantibundhit, Praotasna Sombune, Charturong Tantibundhit, Phongphan Phienphanich, Sombat Muengtaweepongsa, Anuchit Ruamthanthong
This work proposes an automated system for real-time high-accuracy detection of cerebral embolic signals (ES) to couple with transcranial Doppler ultrasound (TCD) devices in diagnosing a risk of stroke. The algorithm employs Adaptive Gain Control (AGC) approach to capture suspected ESs in real-time. Then, Adaptive Wavelet Packet Transform (AWPT) and Fast Fourier Transform (FFT) are used to extract from them features most efficiently representing ES, which determined by Sequential Feature Selection technique...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226889/dual-mode-cmos-analog-front-end-afe-for-electrical-impedance-spectroscopy-eis-systems
#12
Virgilio Valente, Dai Jiang, Andreas Demosthenous, Virgilio Valente, Dai Jiang, Andreas Demosthenous, Dai Jiang, Andreas Demosthenous, Virgilio Valente
This paper presents the operation of a dual-mode wideband CMOS analog front-end (AFE) for electrical impedance spectroscopy. The chip combines two current-readout (CR) channels and four voltage-readout (VR) channels suitable for both bipolar and tetrapolar EIS analysis. The chip addresses the need for flexible readout units for real-time simultaneous single-cell and large scale tissue/organ analysis. Postlayout simulations show that the VR channel is capable of wideband operation up to 12 MHz with noise floor as low as 16...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28205060/validation-of-the-jcog-prognostic-index-in-advanced-gastric-cancer-using-individual-patient-data-from-the-spirits-and-g-sox-trials
#13
Daisuke Takahari, Junki Mizusawa, Wasaburo Koizumi, Ichinosuke Hyodo, Narikazu Boku
BACKGROUND: In a phase III study for advanced gastric cancer (AGC), the Japan Clinical Oncology Group (JCOG) 9912 trial, we previously identified the following four prognostic factors-performance status ≥1, number of metastatic sites ≥2, no prior gastrectomy, and abnormal serum alkaline phosphatase levels-and proposed a prognostic index (good risk with 0 or 1 factor, moderate risk with 2 or 3 factors, and poor risk with all 4 factors). To assess the generalizability of this index, we attempted an external validation study using an independent data set...
February 16, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28195150/molecular-dietary-analysis-of-two-sympatric-felids-in-the-mountains-of-southwest-china-biodiversity-hotspot-and-conservation-implications
#14
Mengyin Xiong, Dajun Wang, Hongliang Bu, Xinning Shao, Dan Zhang, Sheng Li, Rongjiang Wang, Meng Yao
Dietary information is lacking in most of small to mid-sized carnivores due to their elusive predatory behaviour and versatile feeding habits. The leopard cat (LPC; Prionailurus bengalensis) and the Asiatic golden cat (AGC; Catopuma temminckii) are two important yet increasingly endangered carnivore species in the temperate mountain forest ecosystem in Southwest China, a global biodiversity hotspot and a significant reservoir of China's endemic species. We investigated the vertebrate prey of the two sympatric felids using faecal DNA and a next-generation sequencing (NGS)/metabarcoding approach...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28187041/laparoscopy-assisted-versus-open-d2-distal-gastrectomy-for-advanced-gastric-cancer-results-from-a-randomized-phase-ii-multicenter-clinical-trial-coact-1001
#15
Young Kyu Park, Hong Man Yoon, Young-Woo Kim, Ji Yeon Park, Keun Won Ryu, Young-Joon Lee, Oh Jeong, Ki Young Yoon, Jun Ho Lee, Sang Eok Lee, Wansik Yu, Sang-Ho Jeong, Taebong Kim, Sohee Kim, Byoung-Ho Nam
OBJECTIVE: This randomized, phase II, multicenter clinical trial was conducted to evaluate the feasibility of laparoscopy-assisted distal gastrectomy (LADG) with D2 lymph node dissection compared with open distal gastrectomy (ODG) for the treatment of advanced gastric cancer (AGC). SUMMARY OF BACKGROUND DATA: D2 lymph node dissection has been accepted as standard treatment for AGC. Although LADG is widely performed in early gastric cancer (EGC), the feasibility of LADG in AGC has not been proven yet...
March 15, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28174486/aneuploidy-of-chromosome-8-in-circulating-tumor-cells-correlates-with-prognosis-in-patients-with-advanced-gastric-cancer
#16
Yilin Li, Xiaotian Zhang, Jifang Gong, Qiyue Zhang, Jing Gao, Yanshuo Cao, Daisy Dandan Wang, Peter Ping Lin, Lin Shen
OBJECTIVE: Previous work indicated that aneuploidy of chromosome 8 in circulating tumor cells (CTCs) correlated with therapeutic efficacy for advanced gastric cancer (AGC) patients. In this follow-up study performed on the same population of AGC patients, we investigated whether and how aneuploidy of chromosome 8 in CTCs correlates with patients' clinical prognosis. METHODS: The prospective study was performed on 31 patients with newly diagnosed AGC. Previously established integrated subtraction enrichment (SE) and immunostaining-fluorescence in situ hybridization (iFISH) platform was applied to identify, enumerate and characterize CTCs...
December 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28163304/predominant-contribution-of-dgk%C3%AE-over-dgk%C3%AE-in-the-control-of-pkc-pdk-1-regulated-functions-in-t-cells
#17
Antonia Ávila-Flores, Javier Arranz-Nicolás, Elena Andrada, Denise Soutar, Isabel Mérida
Diacylglycerol kinase (DGK)-mediated consumption of the diacylglycerol (DAG) generated in response to antigen recognition is an important mechanism to limit T-cell function. Targeting DGK activity presents new opportunities for therapeutic manipulation of the immune response, but assessment of individual DGK functions is complex. T cells express two DGK isoforms, DGKα and DGKζ, and there are no isoform-specific inhibitors. Here we used short interfering RNA-mediated gene silencing in human T cells and DGKα- and DGKζ-deficient mice to define DGK isoform-specific regulation of key signaling pathways during T-cell activation...
February 28, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28133181/-a-case-of-advanced-gastric-cancer-resected-for-rebleeding-after-palliative-radiotherapy-for-hemostasis
#18
Yusuke Muneoka, Hiroshi Ichikawa, Takashi Ishikawa, Takaaki Hanyu, Yu Sato, Yosuke Kano, Kenji Usui, Takahiro Otani, Mariko Hishiki, Kohei Miura, Masayuki Nagahashi, Jun Sakata, Takashi Kobayashi, Hitoshi Kameyama, Shinichi Kosugi, Toshifumi Wakai
We report a case of advanced gastric cancer(AGC)that was resected for rebleeding after palliative radiotherapy for hemostasis. A 74-year-old man with Stage IV gastric cancer received chemotherapy and achieved stable disease. After 23 months, he experienced continuous bleeding from the tumor due to regrowth. Palliative radiotherapy was conducted to control the bleeding, and the tumor successfully achieved hemostasis. However, 6 weeks later, the patient experienced rebleeding and developed hemostatic shock. We then performed a successful emergency gastrectomy...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28132088/long-term-outcome-after-laparoscopic-gastrectomy-a-multicenter-retrospective-study
#19
Hiroshi Kawase, Yuma Ebihara, Toshiaki Shichinohe, Fumitaka Nakamura, Katsuhiko Murakawa, Takayuki Morita, Shunichi Okushiba, Satoshi Hirano
BACKGROUND: Despite its spread and advances, laparoscopic gastrectomy (LG) for advanced gastric cancer (AGC) remains controversial. The aim of this study was to evaluate the oncologic outcomes and to identify the potential risk factors for recurrence and survival after LG in AGC patients. PATIENTS AND METHODS: The medical records of patients who underwent radical LG for histopathologically diagnosed stage IB or more advanced gastric cancer from 2004 to 2012 were collected...
February 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28131714/indolyl-naphthyl-maleimides-as-potent-and-selective-inhibitors-of-protein-kinase-c-%C3%AE-%C3%AE
#20
Maurice J van Eis, JeanPierre Evenou, Walter Schuler, Gerhard Zenke, Eric Vangrevelinghe, Juergen Wagner, Peter von Matt
The indolyl-naphthyl maleimide 7 is a potent inhibitor of the classical PKC isotypes α,β and shows excellent selectivity over the novel PKC isotypes δ,ε,η,θ and other kinases belonging to the AGC family. The SAR around 7 as well as the physico-chemical characteristics of selected derivatives and their activity in T and B cell activation and proliferation assays are discussed.
January 16, 2017: Bioorganic & Medicinal Chemistry Letters
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