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https://www.readbyqxmd.com/read/29772084/switching-to-tenofovir-vs-continuing-entecavir-for-hbv-with-partial-virologic-response-to-entecavir-a-randomized-controlled-trial
#1
Hyung Joon Yim, In Hee Kim, Sang Jun Suh, Young Kul Jung, Ji Hoon Kim, Yeon Seok Seo, Jong Eun Yeon, Chang Wook Kim, So Young Kwon, Sang Hoon Park, Myung Seok Lee, Soon Ho Um, Kwan Soo Byun
Entecavir 0.5 mg (ETV) is widely used among treatment-naïve chronic hepatitis B (CHB) patients. However, 10%-30% of patients show partial virologic response (PVR) to the drug. If the hepatitis B virus (HBV) continues to replicate, the underlying liver disease may progress. Herein, we compared the efficacy of switching to tenofovir disoproxil fumarate (TDF) with that of continuing ETV in CHB patients with PVR to ETV. This was an open-label randomized controlled trial including CHB patients who had been receiving 0...
May 17, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29768691/detection-of-hepatitis-b-virus-dna-among-chronic-and-potential-occult-hbv-patients-in-resource-limited-settings-by-loop-mediated-isothermal-amplification-assay
#2
Arifa Akram, S M Rashedul Islam, Saif Ullah Munshi, Shahina Tabassum
Transmission of Hepatitis B Virus (HBV) usually occurs due to the transfusion of blood or blood products from chronic HBV (CHB) or occult HBV infected (OBI) patients. Besides serological tests e.g. HBsAg and anti-HBc (total), detection of HBV-DNA is necessary for the diagnosis of OBI patients. Different nucleic acid tests (NATs) including real-time-Polymerase Chain Reaction (qPCR) are used for the detect HBV-DNA. The NATs are expensive and require technical expertise which are barriers to introducing them in resource-limited settings...
May 16, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29766426/seasonal-variations-and-relationships-between-environmental-parameters-and-heavy-metal-concentrations-in-tissues-of-crassostrea-species-and-in-its-ambience-from-the-tropical-estuaries
#3
Prachi Shenai-Tirodkar, Mangesh Gauns, Girish Kumar, Zakir Ansari
This study aimed to evaluate the relationship between physicochemical parameters and heavy metal (Cu, Ni, Pb, and Cd) concentrations from sediment, seawater, and its accumulation in tissues of oyster species (Crassostrea madrasensis and C. gryphoides) from the three sites (Chicalim Bay (CB), Nerul Creek (NC), Chapora Bay (ChB)) along the Goa coast (India). Results showed enrichment of Cu and Ni in sediment exceeding the effect range low (ERL) level. The higher concentrations of Cu and Ni in sediments and in suspended particulate matter (SPM) from all the study sites are indicative of severe contamination of estuarine and associated habitats...
May 15, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29766002/influence-of-vitamin-d-receptor-gene-polymorphisms-on-response-to-pegylated-interferon-in-chronic-hepatitis-b-egyptian-patients
#4
Gomaa Mostafa-Hedeab, Dina Sabry, Ghada Mostafa Abdelaziz, Manal Ewaiss, Nagla Adli, Wael Fathy
Background: We explored the effect of vitamin D receptor gene ( VDR ) polymorphisms in response to PEG-IFN treatment in Egyptian chronic hepatitis B (CHB) patients. Methods: Two hundred hepatitis B virus (HBV) patients (42.3±10.7 years) on PEG-IFN α-2a (180 µg /kg for 48 weeks) and one hundred control subjects (37.3 ±12 years) were enrolled in the study. Vitamin D levels and hepatitis B surface antigen (HBsAg) expression were assessed by ELISA. VDR polymorphisms FokI T>C (rs 10735810), BsmI A>G (rs 1544410), ApaI (rs7975253), and TaqI C>T (rs 731236), were genotyped using real-time PCR...
April 2018: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29765988/genetic-variability-of-the-glucose-dependent-insulinotropic-peptide-gene-is-involved-in-the-premature-coronary-artery-disease-in-a-chinese-population-with-type-2-diabetes
#5
Xiaowei Ma, Jia Huang, Difei Lu, Nan Gu, Ran Lu, Jianwei Zhang, Hong Zhang, Jianping Li, Junqing Zhang, Xiaohui Guo
Background: Glucose-dependent insulinotropic polypeptide (GIP) is closely related to diabetes and obesity, both of which are confirmed to increase the risk of coronary artery disease (CAD). Our study aimed to investigate whether the polymorphisms in GIP genes could affect the risk of cardiovascular disease in type 2 diabetic patients in the Chinese Han population. Methods: We selected and genotyped two haplotype-tagging single nucleotide polymorphisms (tag-SNPs) (rs2291725 C>T, rs8078510 G>A) of GIP gene based on CHB data in HapMap Phase II database ( r 2 < 0...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29765238/higher-baseline-viral-diversity-correlates-with-lower-hbsag-decline-following-pegylated-interferon-alpha-therapy-in-patients-with-hbeag-positive-chronic-hepatitis-b
#6
Hu Li, Li Zhang, Hong Ren, Peng Hu
Background: Viral diversity seems to predict treatment outcomes in certain viral infections. The aim of this study was to evaluate the association between baseline intra-patient viral diversity and hepatitis B surface antigen (HBsAg) decline following PEGylated interferon-alpha (Peg-IFN-α) therapy. Patients and methods: Twenty-six HBeAg-positive patients who were treated with Peg-IFN-α were enrolled. Nested polymerase chain reaction (PCR), cloning, and sequencing of the hepatitis B virus S gene were performed on baseline samples, and normalized Shannon entropy (Sn) was calculated as a measure of small hepatitis B surface protein (SHBs) diversity...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29763915/serum-from-chronic-hepatitis-b-patients-promotes-growth-and-proliferation-via-the-igf-ii-igf-ir-mek-erk-signaling-pathway-in-hepatocellular-carcinoma-cells
#7
Yuanyuan Ji, Zhidong Wang, Haiyan Chen, Lei Zhang, Fei Zhuo, Qingqing Yang
BACKGROUND/AIMS: Chronic hepatitis B virus (HBV) infection (CHB) plays a central role in the etiology of hepatocellular carcinoma (HCC). Emerging evidence implicates insulin-like growth factor (IGF)-II as a major risk factor for the growth and development of HCC. However, the relationship between HBV infection and IGF-II functions remains to be elucidated. METHODS: Levels of circulating IGF-II and IGF-I receptor (IGF-IR) in healthy donors (HDs) and CHB patients were tested by ELISA...
May 9, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29761604/remaining-hepatocellular-carcinoma-risk-in-chronic-hepatitis-b-patients-receiving-entecavir-tenofovir-in-south-korea
#8
Jung Hwan Yu, Young-Joo Jin, Jin-Woo Lee, Don-Haeng Lee
BACKGROUND/AIM: We aimed to identify the incidence rate of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients treated with entecavir or tenofovir in South Korea, and to identify predictors of HCC development in these patients. METHODS: Between January, 2007 and December, 2015, 582 CHB patients initially received entecavir (n=406, 69.8%) or tenofovir (n=176, 30.2%) for CHB. RESULTS: During a median follow-up of 57.1 months, HCC developed in 38 (6...
May 14, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29760793/hepatitis-b-virus-infection-predicts-better-survival-in-patients-with-colorectal-liver-only-metastases-undergoing-liver-resection
#9
Yujie Zhao, Junzhong Lin, Jianhong Peng, Yuxiang Deng, Ruixia Zhao, Qiaoqi Sui, Zhenhai Lu, Desen Wan, Zhizhong Pan
Objective: Hepatitis B virus (HBV) infection has been shown to decrease the risk of liver metastasis in patients with non-metastatic colorectal cancer (CRC). However, the prognostic value of HBV infection in long-term survival of patients with colorectal liver-only metastases (CRLM) after liver resection has not yet been evaluated. This study aims to explore the association between HBV infection and survival in CRLM patients. Methods: A total of 289 CRLM patients undergoing liver resection were recruited at our center from September 1999 to August 2015...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29760545/quantitative-assessment-of-hepatic-fibrosis-in-chronic-hepatitis-b-and-c-t1-mapping-on-gd-eob-dtpa-enhanced-liver-magnetic-resonance-imaging
#10
Shen Pan, Xiao-Qi Wang, Qi-Yong Guo
AIM: To assess the accuracy of Look-Locker on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) for staging liver fibrosis in chronic hepatitis B/C (CHB/C). METHODS: We prospectively included 109 patients with CHB or CHC who underwent a 3.0-Tesla MRI examination, including T1-weighted and Look-Locker sequences for T1 mapping. Hepatocyte fractions (HeF) and relaxation time reduction rate (RE) were measured for staging liver fibrosis...
May 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29758335/normal-on-treatment-alt-during-antiviral-treatment-is-associated-with-a-lower-risk-of-hepatic-events-in-patients-with-chronic-hepatitis-b
#11
Grace Lai-Hung Wong, Henry Lik-Yuen Chan, Yee-Kit Tse, Terry Cheuk-Fung Yip, Kelvin Long-Yan Lam, Grace Chung-Yan Lui, Vincent Wai-Sun Wong
BACKGROUND AND AIMS: Recent studies reveal the rate of normal on-treatment alanine aminotransferase (ALT) appears different for different nucleos(t)ide analogues (NAs); yet its clinical significance is unclear. We aimed to evaluate the impact of normal on-treatment ALT during antiviral treatment with entecavir (ETV) or tenofovir disoproxil fumarate (TDF) in patients with chronic hepatitis B (CHB). METHODS: A territory-wide cohort of CHB patients who received ETV and/or TDF in 2005-2016 was identified...
May 11, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29758333/hepatitis-b-virus-specific-t-cell-responses-after-stopping-nucleos-t-ide-analogue-therapy-in-hbeag-negative-chronic-hepatitis-b
#12
Franziska Rinker, Christine L Zimmer, Christoph Höner Zu Siederdissen, Michael P Manns, Anke R M Kraft, Heiner Wedemeyer, Niklas K Björkström, Markus Cornberg
BACKGROUND AND AIMS: Treatment with nucleos(t)ide analogues (NA) leads to HBV DNA suppression in most patients with chronic hepatitis B (CHB), but HBsAg loss rates are low. Upon NA discontinuation, HBV DNA can return rapidly with ensuing ALT flares and induction of cytokines. Several studies reported higher HBsAg loss rates after stopping therapy, but at present, it is unclear if cell-mediated immune responses are altered after treatment discontinuation. The aim of this study was to characterise T cell responses during the early phase of virological relapse following discontinuation of NA therapy in HBeAg-negative patients...
May 11, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29755645/hepatic-steatosis-in-chronic-hepatitis-b-a-study-of-metabolic-and-genetic-factors
#13
Michael O Baclig, Karen G Reyes, Veni R Liles, Cynthia A Mapua, Mark Pierre S Dimamay, Juliet Gopez-Cervantes
Hepatic steatosis is a common finding in liver biopsy and may co-exist with chronic hepatitis B (CHB) infection. The aims of this study were to determine the prevalence of steatosis in CHB patients among Filipinos; determine the factors related to the presence of steatosis among individuals with and without CHB infection; and to investigate the possible association between steatosis and polymorphism in interleukin 28B (IL28B) gene. The presence of steatosis was correlated with clinical, biochemical and histological parameters...
2018: International Journal of Molecular Epidemiology and Genetics
https://www.readbyqxmd.com/read/29753730/expression-and-significance-of-peripheral-myeloid-derived-suppressor-cells-in-chronic-hepatitis-b-patients
#14
Y Lv, M Cui, Z Lv, J Lu, X Zhang, Z Zhao, Y Wang, L Gao, N M Tsuji, H Yan
BACKGROUND: Myeloid-derived suppressor cells (MDSCs) exert their suppressive effects on multiple immune response and contribute to the development of many diseases. However, limited data is available on the involvement of MDSCs in human chronic HBV infection. OBJECTIVE: To investigate whether the progression of chronic HBV infection was associated with imbalance of MDSCs. METHODS: The percentages of MDSCs, regulatory T (Treg), Th1 and Tc1 cells in the peripheral blood from chronic hepatitis B (CHB) patients and healthy controls (HC) were determined by flow cytometry...
May 9, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29753054/psoriatic-patients-with-chronic-viral-hepatitis-do-not-have-an-increased-risk-of-liver-cirrhosis-despite-long-term-methotrexate-use-real-world-data-from-a-nationwide-cohort-study-in-taiwan
#15
Kuo-Tung Tang, Yi-Ming Chen, Shih-Ni Chang, Ching-Heng Lin, Der-Yuan Chen
BACKGROUND: Methotrexate (MTX) is commonly used in the treatment of patients with moderate to severe psoriasis. OBJECTIVE: We conducted a nationwide population-based cohort study to investigate the impact of long-term MTX use on the risk of chronic viral hepatitis-related cirrhosis among psoriatic patients in Taiwan. METHODS: This study obtained data from the National Health Insurance Research Database in Taiwan. We identified 2417 psoriatic patients with chronic hepatitis B (CHB) (370 MTX users and 2047 MTX non-users) and 1127 psoriatic patients with chronic hepatitis C (CHC) (174 MTX users and 953 MTX non-users) from January 1, 2000 to December 31, 2010...
May 9, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29743020/ifi16-is-involved-in-hbv-associated-acute-on-chronic-liver-failure-inflammation
#16
Xiuqing Pang, Xinhua Li, Zhishuo Mo, Jing Huang, Hong Deng, Ziying Lei, Xingrong Zheng, Zhiying Feng, Dongying Xie, Zhiliang Gao
BACKGROUND: Hepatitis B virus (HBV) is a hepatotropic DNA virus, and its DNA may be a potent inflammatory molecule. Interferon-inducible protein 16 (IFI16), a newly discovered DNA sensor, plays an important role in the process of inflammation in viral infections. Our study sought to identify a correlation between IFI16 expression and inflammation in patients with chronic hepatitis B (CHB) and HBV-associated acute-on-chronic liver failure (HBV-ACLF). METHODS: We performed flow cytometry to measure IFI16 levels in peripheral blood mononuclear cells (PBMC) and used immunohistochemistry and western blotting to measure IFI16 protein levels in liver tissues...
May 9, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29741704/incidence-and-predictors-of-hbsag-loss-after-peginterferon-therapy-in-hbeag-negative-chronic-hepatitis-b-a-multicenter-long-term-follow-up-study
#17
I-Cheng Lee, Sien-Sing Yang, Chieh-Ju Lee, Chien-Wei Su, Yuan-Jen Wang, Keng-Hsin Lan, Han-Chieh Lin, Ming-Chih Hou, Cheng-Yuan Peng, Yi-Hsiang Huang
Background: The long-term incidence and factors associated with HBsAg loss in HBeAg-negative chronic hepatitis B (CHB) patients receiving peginterferon is rarely reported. Methods: From 2004 to 2016, 233 HBeAg-negative CHB patients who completed 48 weeks of peginterferon treatment from three medical centers in Taiwan were retrospectively enrolled. Results: During a median follow-up of 7.4 years, 27 cases achieved HBsAg loss. The cumulative incidences of HBsAg loss and HBsAg seroconversion at 3, 5, 10 years after peginterferon treatment were 4...
May 7, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29741286/comparison-of-overall-survival-between-antiviral-induced-viral-suppression-and-inactive-phase-chronic-hepatitis-b-patients
#18
Young Youn Cho, Jeong-Hoon Lee, Young Chang, Joon Yeul Nam, Hyeki Cho, Dong Hyeon Lee, Eun Ju Cho, Dong Ho Lee, Su Jong Yu, Jeong Min Lee, Yoon Jun Kim, Jung-Hwan Yoon
Nucleot(s)ide analogues (NAs) reduce the risk of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients. However, the risk of HCC is reportedly higher for NA-treated patients than for patients in the inactive CHB phase. This study aimed to compare the long-term outcomes of CHB patients with NA-induced viral suppression and those of patients with inactive CHB. This retrospective study involved 1,118 consecutive CHB patients whose HBV DNA level was continuously <2,000 IU/mL during follow up with/without antiviral agents...
May 9, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29741285/systematic-review-and-meta-analysis-development-of-hepatocellular-carcinoma-in-chronic-hepatitis-b-patients-with-hepatitis-e-antigen-seroconversion
#19
Tai-Cheng Zhou, Xin Lai, Mu-Hua Feng, Yang Tang, Liang Zhang, Jia Wei
Hepatitis B e antigen (HBeAg) seroconversion is considered to have significantly favorable clinical outcomes for patients with chronic hepatitis B (CHB). However, inconsistent study results suggest that hepatocellular carcinoma (HCC) still occurs in patients with HBeAg seroconversion. We performed a systematic review and meta-analysis to determine the incidence of HCC in patients with CHB after HBeAg seroconversion. Web of Science, PubMed and EMBASE databases were searched through July 2017. The incidence of HCC in CHB patients after HBeAg seroconversion was pooled using a random-effects model or fix-effects model...
May 9, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29741221/a-novel-index-using-routinely-clinical-parameters-for-predicting-significant-liver-inflammation-in-chronic-hepatitis-b
#20
Jian Wang, Juan Xia, Rui Zhang, Xiaomin Yan, Yue Yang, Xiang-An Zhao, Haiyan Chang, Guiyang Wang, Guangmei Chen, Yong Liu, Yuxin Chen, Bei Jia, Zhaoping Zhang, Weimao Ding, Rui Huang, Chao Wu
Identifying the degree of liver inflammation is critical for therapeutic judgment of patients with chronic hepatitis B(CHB). However, we lack indexes which can accurately predict significant liver inflammation in CHB patients. This study aimed to develop a simple predictive index for liver inflammation in CHB using routine clinical parameters. 519 CHB patients who underwent liver biopsy were enrolled and randomly divided into training(n=346) and validation cohorts(n=173). Based on routine clinical parameters, gamma-glutamyl transpeptidase(GGT)(P=0...
May 9, 2018: Journal of Viral Hepatitis
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