Osayimwen Imade, Bobola V Ilesanmi, Germaine O Ogunwole, Olusola O Elekofehinti, Marília Cristina Oliveira Souza, Fernando Barbosa, Chris O Adedire, Joseph A Adeyemi
The toxic effects of 2, 4-dichlorophenol (2, 4-DCP) on aquatic organisms are well-established; however, the details regarding the mechanisms underlying the toxicity, especially immunotoxicity are poorly understood. Consequently, the aim of this study was to investigate the histopathologic, oxidative stress and immunotoxic effects attributed to exposure to sublethal concentrations of 2,4-DCP in the African catfish, Clarias gariepinus . Juvenile C. gariepinus were exposed to 0.4, 0.8, or 1.6 mg/L 2, 4-DCP for 28 days after which blood and head kidney were extracted for the determination of various nonspecific innate immune parameters while the liver was excised for histopathology examination and measurement of oxidative stress biomarkers...
April 9, 2024: Journal of Toxicology and Environmental Health. Part A