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https://www.readbyqxmd.com/read/29329291/ovule-identity-mediated-by-pre-mrna-processing-in-arabidopsis
#1
Encarnación Rodríguez-Cazorla, Samanta Ortuño-Miquel, Héctor Candela, Lindsay J Bailey-Steinitz, Martin F Yanofsky, Antonio Martínez-Laborda, Juan-José Ripoll, Antonio Vera
Ovules are fundamental for plant reproduction and crop yield as they are the precursors of seeds. Therefore, ovule specification is a critical developmental program. In Arabidopsis thaliana, ovule identity is redundantly conferred by the homeotic D-class genes SHATTERPROOF1 (SHP1), SHP2 and SEEDSTICK (STK), phylogenetically related to the MADS-domain regulatory gene AGAMOUS (AG), essential in floral organ specification. Previous studies have shown that the HUA-PEP activity, comprised of a suite of RNA-binding protein (RBP) encoding genes, regulates AG pre-mRNA processing and thus flower patterning and organ identity...
January 12, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29320160/efforts-aimed-to-reduce-attrition-in-antimalarial-drug-discovery-a-systematic-evaluation-of-current-antimalarial-targets-portfolio
#2
María Jesus Chaparro, Felix Calderon, Pablo Castañeda, Elena Fernandez Alvaro, Raquel Gabarro, Francisco-Javier Gamo, María G Gómez-Lorenzo, Julio Martín, Esther Fernandez
Malaria remains a major global health problem. In 2015 alone, more than 200 million cases of malaria were reported, and more than 400,000 deaths occurred. Since 2010, emerging resistance to current front-line ACTs (Artemisinin Combination Therapies) has been detected in endemic countries. Therefore, there is an urgency for new therapies based on novel modes of action, able to relieve symptoms as fast as the artemisinins and/or block malaria transmission. During the past few years, the antimalarial community has focused their efforts on phenotypic screening as a pragmatic approach to identify new hits...
January 10, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29309204/toxicological-and-ecotoxicological-properties-of-gas-to-liquid-gtl-products-2-ecotoxicology
#3
Graham F Whale, James Dawick, Christopher B Hughes, Delina Lyon, Peter J Boogaard
Gas-to-liquid (GTL) products are synthetic hydrocarbons produced from natural gas using a catalytic process known as the Fischer-Tropsch process. This process yields a synthetic crude oil that consists of saturated hydrocarbons which can subsequently be refined to a range of products analogous to those obtained from petroleum refining. However, in contrast to their petroleum-derived analogs, GTL products are essentially free of unsaturated or aromatic compounds and do not contain any sulfur-, oxygen-, or nitrogen-containing compounds...
January 8, 2018: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/29297394/appropriateness-and-timeliness-of-care-seeking-for-complications-of-pregnancy-and-childbirth-in-rural-ethiopia-a-case-study-of-the-maternal-and-newborn-health-in-ethiopia-partnership
#4
Lynn M Sibley, Yared Amare, Solomon Tesfaye Abebe, Mulusew Lijalem Belew, Kemeredin Shiffra, Danika Barry
BACKGROUND: In 2014, USAID and University Research Co., LLC, initiated a new project under the broader Translating Research into Action portfolio of projects. This new project was entitled Systematic Documentation of Illness Recognition and Appropriate Care Seeking for Maternal and Newborn Complications. This project used a common protocol involving descriptive mixed-methods case studies of community projects in six low- and middle-income countries, including Ethiopia. In this paper, we present the Maternal and Newborn Health in Ethiopia Partnership (MaNHEP) case study...
December 21, 2017: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/29233393/assessing-self-assessment-practices-a-survey-of-u-s-colleges-and-schools-of-pharmacy
#5
James S Wheeler, Sharon L K McDonough, Tracy M Hagemann
OBJECTIVE: This study quantifies and describes student self-assessment approaches in colleges of pharmacy across the United States. METHODS: Faculty members identified as assessment directors from college websites at U.S. colleges of pharmacy were electronically surveyed. Prior to distribution, feedback and question validation was sought from select assessment directors. Surveys were distributed and recorded, via Qualtrics® survey software and analyzed in Microsoft Excel®...
November 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29200459/competency-programming-and-emerging-innovation-in-graduate-education-within-schools-of-pharmacy-the-report-of-the-2016-2017-research-and-graduate-affairs-committee
#6
Samuel M Poloyac, Kirsten F Block, Jane E Cavanaugh, Linda P Dwoskin, Russell B Melchert, Ruth E Nemire, James M O'Donnell, Ronny Priefer, Daniel R Touchette
Graduate education in the pharmaceutical sciences is a cornerstone of research within pharmacy schools. Pharmaceutical scientists are critical contributors to addressing the challenges of new drug discovery, delivery, and optimal care in order to ensure improved therapeutic outcomes in populations of patients. The American Association of Colleges of Pharmacy (AACP) charged the 2016-2017 Research and Graduate Affairs Committee (RGAC) to define the competencies necessary for graduate education in the pharmaceutical sciences (Charge 1), recommend collaborative curricular development across schools of pharmacy (Charge 2), recommend AACP programing for graduate education (Charge 3), and provide guidance on emerging areas for innovation in graduate education (Charge 4)...
October 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/29200453/targeting-assessment-for-learning-within-pharmacy-education
#7
Michael J Peeters
Formative assessment is critical for deliberate improvement, development and growth. While not entirely synonymous, assessment for learning (AFL) is an approach using formative assessment to specifically improve students' learning. While using formative assessments, AFL can also have summative programmatic-assessment implications. For each learning assessment, summative and formative uses can be leveraged; it can scaffold (formative), foster students' growth (formative), and document students' development in a competency/standard (summative)...
October 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/29178891/rationale-and-design-for-sharehd-a-quality-improvement-collaborative-to-scale-up-shared-haemodialysis-care-for-patients-on-centre-based-haemodialysis
#8
James Fotheringham, Tania Barnes, Louese Dunn, Sonia Lee, Steven Ariss, Tracey Young, Stephen J Walters, Paul Laboi, Andy Henwood, Rachel Gair, Martin Wilkie
BACKGROUND: The study objective is to assess the effectiveness and economic impact of a structured programme to support patient involvement in centre-based haemodialysis and to understand what works for whom in what circumstances and why. It implements a program of Shared Haemodialysis Care (SHC) that aims to improve experience and outcomes for those who are treated with centre-based haemodialysis, and give more patients the confidence to dialyse independently both at centres and at home...
November 24, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29177217/how-to-design-and-deliver-a-local-teaching-program
#9
Christopher Limb, Katharine Whitehurst, Buket Gundogan, Kiron Koshy, Riaz Agha
Teaching is an invaluable aspect of any medical or surgical career. Many trainees will find themselves delivering teaching at several stages in their career and in this "How to" article we explain how to design, set up, and deliver a successful teaching program, as well as how to evidence this in your portfolio.
July 2017: International Journal of Surgery. Oncology
https://www.readbyqxmd.com/read/29143632/a-method-for-estimating-maternal-and-newborn-lives-saved-from-health-related-investments-funded-by-the-uk-government-department-for-international-development-using-the-lives-saved-tool
#10
Ingrid K Friberg, Angela Baschieri, Jo Abbotts
BACKGROUND: In 2010, the UK Government Department for International Development (DFID) committed through its 'Framework for results for reproductive, maternal and newborn health (RMNH)' to save 50,000 maternal lives and 250,000 newborn lives by 2015. They also committed to monitoring the performance of this portfolio of investments to demonstrate transparency and accountability. Methods currently available to directly measure lives saved are cost-, time-, and labour-intensive. The gold standard for calculating the total number of lives saved would require measuring mortality with large scale population based surveys or annual vital events surveillance...
November 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29126405/electronic-portfolio-use-in-pediatric-residency-and-perceived-efficacy-as-a-tool-for-teaching-lifelong-learning
#11
Annabel Frank, Kimberly Gifford
BACKGROUND: Residency programs use electronic portfolios (efolios) to organize data, track resident performance, and sometimes teach and assess lifelong learning (LLL) skills. Published studies on efolios in graduate medical education are mostly descriptions of implementation at individual institutions. METHODS: An anonymous online survey was sent to 199 pediatric residency program directors across the United States. Efolio usage patterns were described and compared between program directors that perceived efolios effective at fostering LLL and those that did not...
November 10, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29114346/enhanced-skills-in-global-health-and-health-equity-guidelines-for-curriculum-development
#12
Russell Dawe, Andrea Pike, Monica Kidd, Praseedha Janakiram, Eileen Nicolle, Jill Allison
Introduction: Global health addresses health inequities in the care of underserved populations, both domestic and international. Given that health systems with a strong primary care foundation are the most equitable, effective and efficient, family medicine is uniquely positioned to engage in global health. However, there are no nationally recognized standards in Canada for postgraduate family medicine training in global health. Objective: To generate consensus on the essential components of a Global Health/Health Equity Enhanced Skills Program in family medicine...
April 2017: Canadian Medical Education Journal
https://www.readbyqxmd.com/read/29074340/evaluation-of-clinical-teaching-quality-in-competency-based-residency-training-in-lithuania
#13
Eglė Vaižgėlienė, Žilvinas Padaiga, Daiva Rastenytė, Algimantas Tamelis, Kęstutis Petrikonis, Cornelia Fluit
BACKGROUND AND AIM: In 2013, all residency programs at the Lithuanian University of Health Sciences were renewed into the competency-based medical education curriculum (CBME). In 2015, we implemented the validated EFFECT questionnaire together with the EFFECT-System for quality assessment of clinical teaching in residency training. The aim of this study was to investigate the influence of characteristics of the resident (year of training) and clinical teacher (gender, age, and type of academic position) on teaching quality, as well as to assess areas for teaching quality improvement...
September 7, 2017: Medicina
https://www.readbyqxmd.com/read/29046674/tbvac2020-advancing-tuberculosis-vaccines-from-discovery-to-clinical-development
#14
REVIEW
Stefan H E Kaufmann, Hazel M Dockrell, Nick Drager, Mei Mei Ho, Helen McShane, Olivier Neyrolles, Tom H M Ottenhoff, Brij Patel, Danielle Roordink, François Spertini, Steffen Stenger, Jelle Thole, Frank A W Verreck, Ann Williams
TBVAC2020 is a research project supported by the Horizon 2020 program of the European Commission (EC). It aims at the discovery and development of novel tuberculosis (TB) vaccines from preclinical research projects to early clinical assessment. The project builds on previous collaborations from 1998 onwards funded through the EC framework programs FP5, FP6, and FP7. It has succeeded in attracting new partners from outstanding laboratories from all over the world, now totaling 40 institutions. Next to the development of novel vaccines, TB biomarker development is also considered an important asset to facilitate rational vaccine selection and development...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29046431/a-survey-of-perceived-effectiveness-of-part-4-maintenance-of-certification
#15
Joel S Tieder, Sean P Prall, Jimmy Beck, Erin Alberda, Debra Jensen, Deepthi Nair, Jan D Carline
OBJECTIVES: Evaluative assessment is needed to inform improvement of Part 4 Maintenance of Certification (MOC), a large-scale program that aims to improve physician knowledge, engagement, and skills in quality improvement (QI). We sought to determine if Part 4 MOC participation improves perceived educational and clinical outcomes by piloting a new physician survey. METHODS: We administered a new online survey (MOC Practice, Engagement, Attitude, and Knowledge Survey) to physicians at the beginning and end of a Part 4 MOC project sponsored by a pediatric hospital's American Board of Medical Specialties' portfolio program during 2015...
November 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/28970192/efficacy-of-seren-ctif-a-computer-based-stress-management-program-for-patients-with-adjustment-disorder-with-anxiety-protocol-for-a-controlled-trial
#16
Dominique Servant, Anne-Claire Leterme, Olivia Barasino, Laure Rougegrez, Alain Duhamel, Guillaume Vaiva
BACKGROUND: Adjustment disorder with anxiety (ADA) is the most frequent and best characterized stress-related psychiatric disorder. The rationale for prescription of benzodiazepine monotherapy is a public health issue. Cognitive behavioral stress management programs have been studied in many countries. Several reports have shown beyond reasonable doubt their efficiency at reducing perceived stress and anxiety symptoms and improving patient quality of life. Considering the number of people who could benefit from such programs but are unable to access them, self-help programs have been offered...
October 2, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28967423/implementation-of-a-novel-portfolio-of-structured-curriculum-aligned-simulation-based-cardiothoracic-surgery-training-courses-evolving-the-delivery-of-surgical-education
#17
Narain Moorjani, Michael Lewis, Rajesh Shah, Sion Barnard, Tim Graham, Sridhar Rathinam
OBJECTIVE: The provision of high-quality cardiothoracic surgical training faces many challenges. This has generated an increased interest in simulation-based learning, which can provide a less stressful environment for deliberate practice. We developed a comprehensive, structured program of knowledge and simulation-based learning aligned to the official cardiothoracic surgery curriculum. METHODS: A portfolio of 10 curriculum-aligned training courses was designed for cardiothoracic surgical trainees during their 6-year training program...
August 24, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28957024/sparse-covariance-matrix-estimation-by-dca-based-algorithms
#18
Duy Nhat Phan, Hoai An Le Thi, Tao Pham Dinh
This letter proposes a novel approach using the [Formula: see text]-norm regularization for the sparse covariance matrix estimation (SCME) problem. The objective function of SCME problem is composed of a nonconvex part and the [Formula: see text] term, which is discontinuous and difficult to tackle. Appropriate DC (difference of convex functions) approximations of [Formula: see text]-norm are used that result in approximation SCME problems that are still nonconvex. DC programming and DCA (DC algorithm), powerful tools in nonconvex programming framework, are investigated...
November 2017: Neural Computation
https://www.readbyqxmd.com/read/28837889/humanized-mouse-models-for-epstein-barr-virus-infection
#19
REVIEW
Christian Münz
It is essential for the human immune system to control Epstein Barr virus (EBV), because this common human γ-herpesvirus efficiently spreads through the human population with more than 90% being persistently infected after 20 years of age even in developed countries. Moreover, it threatens each host with its potent growth transforming properties, readily immortalizing human B cells into persistently growing lymphoma cell lines. Since this virus only infects humans, mice with reconstituted human immune system components provide an informative in vivo model to study EBV infection, the associated tumor formation and immune control thereof...
August 21, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28811131/assessment-of-translational-risk-in-drug-research-role-of-biomarker-classification-and-mechanism-based-pkpd-concepts
#20
REVIEW
Sandra A G Visser, Tjerk J H Bueters
In 2005, Danhof and coauthors proposed a new biomarker classification in the context of the application of mechanism-based PKPD modeling. They defined the term 'biomarker' as a measure that characterizes a drug-induced response, which is on the causal path between drug administration and clinical outcome. The biomarker classification identified seven categories that provide different insights into the kinetics of drug action, such as target site distribution, target engagement, or into the impact of the drug on physiology or disease...
November 15, 2017: European Journal of Pharmaceutical Sciences
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