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https://www.readbyqxmd.com/read/29143632/a-method-for-estimating-maternal-and-newborn-lives-saved-from-health-related-investments-funded-by-the-uk-government-department-for-international-development-using-the-lives-saved-tool
#1
Ingrid K Friberg, Angela Baschieri, Jo Abbotts
BACKGROUND: In 2010, the UK Government Department for International Development (DFID) committed through its 'Framework for results for reproductive, maternal and newborn health (RMNH)' to save 50,000 maternal lives and 250,000 newborn lives by 2015. They also committed to monitoring the performance of this portfolio of investments to demonstrate transparency and accountability. Methods currently available to directly measure lives saved are cost-, time-, and labour-intensive. The gold standard for calculating the total number of lives saved would require measuring mortality with large scale population based surveys or annual vital events surveillance...
November 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29126405/electronic-portfolio-use-in-pediatric-residency-and-perceived-efficacy-as-a-tool-for-teaching-lifelong-learning
#2
Annabel Frank, Kimberly Gifford
BACKGROUND: Residency programs use electronic portfolios (efolios) to organize data, track resident performance, and sometimes teach and assess lifelong learning (LLL) skills. Published studies on efolios in graduate medical education are mostly descriptions of implementation at individual institutions. METHODS: An anonymous online survey was sent to 199 pediatric residency program directors across the United States. Efolio usage patterns were described and compared between program directors that perceived efolios effective at fostering LLL and those that did not...
November 10, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29114346/enhanced-skills-in-global-health-and-health-equity-guidelines-for-curriculum-development
#3
Russell Dawe, Andrea Pike, Monica Kidd, Praseedha Janakiram, Eileen Nicolle, Jill Allison
Introduction: Global health addresses health inequities in the care of underserved populations, both domestic and international. Given that health systems with a strong primary care foundation are the most equitable, effective and efficient, family medicine is uniquely positioned to engage in global health. However, there are no nationally recognized standards in Canada for postgraduate family medicine training in global health. Objective: To generate consensus on the essential components of a Global Health/Health Equity Enhanced Skills Program in family medicine...
April 2017: Canadian Medical Education Journal
https://www.readbyqxmd.com/read/29074340/evaluation-of-clinical-teaching-quality-in-competency-based-residency-training-in-lithuania
#4
Eglė Vaižgėlienė, Žilvinas Padaiga, Daiva Rastenytė, Algimantas Tamelis, Kęstutis Petrikonis, Cornelia Fluit
BACKGROUND AND AIM: In 2013, all residency programs at the Lithuanian University of Health Sciences were renewed into the competency-based medical education curriculum (CBME). In 2015, we implemented the validated EFFECT questionnaire together with the EFFECT-System for quality assessment of clinical teaching in residency training. The aim of this study was to investigate the influence of characteristics of the resident (year of training) and clinical teacher (gender, age, and type of academic position) on teaching quality, as well as to assess areas for teaching quality improvement...
September 7, 2017: Medicina
https://www.readbyqxmd.com/read/29046674/tbvac2020-advancing-tuberculosis-vaccines-from-discovery-to-clinical-development
#5
REVIEW
Stefan H E Kaufmann, Hazel M Dockrell, Nick Drager, Mei Mei Ho, Helen McShane, Olivier Neyrolles, Tom H M Ottenhoff, Brij Patel, Danielle Roordink, François Spertini, Steffen Stenger, Jelle Thole, Frank A W Verreck, Ann Williams
TBVAC2020 is a research project supported by the Horizon 2020 program of the European Commission (EC). It aims at the discovery and development of novel tuberculosis (TB) vaccines from preclinical research projects to early clinical assessment. The project builds on previous collaborations from 1998 onwards funded through the EC framework programs FP5, FP6, and FP7. It has succeeded in attracting new partners from outstanding laboratories from all over the world, now totaling 40 institutions. Next to the development of novel vaccines, TB biomarker development is also considered an important asset to facilitate rational vaccine selection and development...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29046431/a-survey-of-perceived-effectiveness-of-part-4-maintenance-of-certification
#6
Joel S Tieder, Sean P Prall, Jimmy Beck, Erin Alberda, Debra Jensen, Deepthi Nair, Jan D Carline
OBJECTIVES: Evaluative assessment is needed to inform improvement of Part 4 Maintenance of Certification (MOC), a large-scale program that aims to improve physician knowledge, engagement, and skills in quality improvement (QI). We sought to determine if Part 4 MOC participation improves perceived educational and clinical outcomes by piloting a new physician survey. METHODS: We administered a new online survey (MOC Practice, Engagement, Attitude, and Knowledge Survey) to physicians at the beginning and end of a Part 4 MOC project sponsored by a pediatric hospital's American Board of Medical Specialties' portfolio program during 2015...
October 18, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/28970192/efficacy-of-seren-ctif-a-computer-based-stress-management-program-for-patients-with-adjustment-disorder-with-anxiety-protocol-for-a-controlled-trial
#7
Dominique Servant, Anne-Claire Leterme, Olivia Barasino, Laure Rougegrez, Alain Duhamel, Guillaume Vaiva
BACKGROUND: Adjustment disorder with anxiety (ADA) is the most frequent and best characterized stress-related psychiatric disorder. The rationale for prescription of benzodiazepine monotherapy is a public health issue. Cognitive behavioral stress management programs have been studied in many countries. Several reports have shown beyond reasonable doubt their efficiency at reducing perceived stress and anxiety symptoms and improving patient quality of life. Considering the number of people who could benefit from such programs but are unable to access them, self-help programs have been offered...
October 2, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28967423/implementation-of-a-novel-portfolio-of-structured-curriculum-aligned-simulation-based-cardiothoracic-surgery-training-courses-evolving-the-delivery-of-surgical-education
#8
Narain Moorjani, Michael Lewis, Rajesh Shah, Sion Barnard, Tim Graham, Sridhar Rathinam
OBJECTIVE: The provision of high-quality cardiothoracic surgical training faces many challenges. This has generated an increased interest in simulation-based learning, which can provide a less stressful environment for deliberate practice. We developed a comprehensive, structured program of knowledge and simulation-based learning aligned to the official cardiothoracic surgery curriculum. METHODS: A portfolio of 10 curriculum-aligned training courses was designed for cardiothoracic surgical trainees during their 6-year training program...
August 24, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28957024/sparse-covariance-matrix-estimation-by-dca-based-algorithms
#9
Duy Nhat Phan, Hoai An Le Thi, Tao Pham Dinh
This letter proposes a novel approach using the [Formula: see text]-norm regularization for the sparse covariance matrix estimation (SCME) problem. The objective function of SCME problem is composed of a nonconvex part and the [Formula: see text] term, which is discontinuous and difficult to tackle. Appropriate DC (difference of convex functions) approximations of [Formula: see text]-norm are used that result in approximation SCME problems that are still nonconvex. DC programming and DCA (DC algorithm), powerful tools in nonconvex programming framework, are investigated...
November 2017: Neural Computation
https://www.readbyqxmd.com/read/28837889/humanized-mouse-models-for-epstein-barr-virus-infection
#10
REVIEW
Christian Münz
It is essential for the human immune system to control Epstein Barr virus (EBV), because this common human γ-herpesvirus efficiently spreads through the human population with more than 90% being persistently infected after 20 years of age even in developed countries. Moreover, it threatens each host with its potent growth transforming properties, readily immortalizing human B cells into persistently growing lymphoma cell lines. Since this virus only infects humans, mice with reconstituted human immune system components provide an informative in vivo model to study EBV infection, the associated tumor formation and immune control thereof...
August 21, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28811131/assessment-of-translational-risk-in-drug-research-role-of-biomarker-classification-and-mechanism-based-pkpd-concepts
#11
REVIEW
Sandra A G Visser, Tjerk J H Bueters
In 2005, Danhof and coauthors proposed a new biomarker classification in the context of the application of mechanism-based PKPD modeling. They defined the term 'biomarker' as a measure that characterizes a drug-induced response, which is on the causal path between drug administration and clinical outcome. The biomarker classification identified seven categories that provide different insights into the kinetics of drug action, such as target site distribution, target engagement, or into the impact of the drug on physiology or disease...
November 15, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28762988/defining-scholarship-in-physician-assistant-education
#12
Deborah A Opacic, Elizabeth Roessler
The goal of educational scholarship is to establish evidence that identifies excellence in teaching, curriculum design, student assessment, mentoring, advising, leadership, and administration. Our challenge as faculty is to determine what best defines this within our profession. Responsibilities of physician assistant (PA) educators include not only increasing evidence supporting quality in PA education but also outlining strategies that lead us to this success. As innovative scholars, we should focus on expanding the definition of educational scholarship by reevaluating criteria that define it...
July 28, 2017: Journal of Physician Assistant Education
https://www.readbyqxmd.com/read/28761888/program-evaluation-of-an-integrated-basic-science-medical-curriculum-in-shiraz-medical-school-using-cipp-evaluation-model
#13
Azadeh Rooholamini, Mitra Amini, Leila Bazrafkan, Mohammad Reza Dehghani, Zohreh Esmaeilzadeh, Parisa Nabeiei, Rita Rezaee, Javad Kojuri
INTRODUCTION: In recent years curriculum reform and integration was done in many medical schools. The integrated curriculum is a popular concept all over the world. In Shiraz medical school, the reform was initiated by stablishing the horizontal basic science integration model and Early Clinical Exposure (ECE) for undergraduate medical education. The purpose of this study was to provide the required data for the program evaluation of this curriculum for undergraduate medical students, using CIPP program evaluation model...
July 2017: Journal of Advances in Medical Education & Professionalism
https://www.readbyqxmd.com/read/28761071/phosphopredict-a-bioinformatics-tool-for-prediction-of-human-kinase-specific-phosphorylation-substrates-and-sites-by-integrating-heterogeneous-feature-selection
#14
Jiangning Song, Huilin Wang, Jiawei Wang, André Leier, Tatiana Marquez-Lago, Bingjiao Yang, Ziding Zhang, Tatsuya Akutsu, Geoffrey I Webb, Roger J Daly
Protein phosphorylation is a major form of post-translational modification (PTM) that regulates diverse cellular processes. In silico methods for phosphorylation site prediction can provide a useful and complementary strategy for complete phosphoproteome annotation. Here, we present a novel bioinformatics tool, PhosphoPredict, that combines protein sequence and functional features to predict kinase-specific substrates and their associated phosphorylation sites for 12 human kinases and kinase families, including ATM, CDKs, GSK-3, MAPKs, PKA, PKB, PKC, and SRC...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28755542/towards-an-evidence-based-approach-for-the-development-of-adjuvanted-vaccines
#15
REVIEW
Derek T O'Hagan, Leonard R Friedland, Emmanuel Hanon, Arnaud M Didierlaurent
In the last two decades, several vaccines formulated with a new generation of adjuvants have been licensed or approved to target diseases such as influenza, hepatitis B, cervical cancer, and malaria. These new generation adjuvants appear to work by delivering a localized activation signal to the innate immune system, which in turn promotes antigen-specific adaptive immunity. Advances in understanding of the innate immune system together with high-throughput discovery of synthetic immune potentiators are now expanding the portfolio of new generation adjuvants available for evaluation...
July 26, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/28727487/improving-care-with-a-portfolio-of-physician-led-cancer-quality-measures-at-an-academic-center
#16
Julie Bryar Porter, Eben Lloyd Rosenthal, Marcy Winget, Andrea Segura Smith, Sridhar Belavadi Seshadri, Yohan Vetteth, Eileen F Kiamanesh, Amogh Badwe, Ranjana H Advani, Mark K Buyyounouski, Steven Coutre, Frederick Dirbas, Vasu Divi, Oliver Dorigo, Kristen N Ganjoo, Laura J Johnston, Lawrence David Recht, Joseph B Shrager, Eila C Skinner, Susan M Swetter, Brendan C Visser, Douglas W Blayney
PURPOSE: Development and implementation of robust reporting processes to systematically provide quality data to care teams in a timely manner is challenging. National cancer quality measures are useful, but the manual data collection required is resource intensive, and reporting is delayed. We designed a largely automated measurement system with our multidisciplinary cancer care programs (CCPs) to identify, measure, and improve quality metrics that were meaningful to the care teams and their patients...
August 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28711646/rural-rotations-at-core-rarefied-exposure-or-real-experience
#17
Christopher Brown, Tarig Abdelrahman, Neil Patel, Awen Iorwerth, John Pollitt, Mark Holt, Wyn G Lewis
OBJECTIVE: Surgical rotations involving rural General Hospitals (rGH) are frequently associated with recruitment challenges, partly because of adverse perceptions regarding distances from social support networks and training opportunities. The aim of this study was to determine the outcomes of core surgical training rotations involving rGHs when compared with urban hospitals in a single UK Deanery. DESIGN: Online Intercollegiate Surgical Curriculum Programme portfolios from 163 core surgical trainees (CST) were examined related to postlocation, operative experience, workplace-based assessments, and academic achievement...
July 12, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28685213/telemedicine-and-its-transformation-of-emergency-care-a-case-study-of-one-of-the-largest-us-integrated-healthcare-delivery-systems
#18
Rahul Sharma, Peter Fleischut, Daniel Barchi
Innovative methods for delivering healthcare via the use of technology are rapidly growing. Despite the passage of the Affordable Care Act, emergency department visits have continued to rise nationally. Healthcare systems must devise solutions to face these increasing volumes and also deliver high quality care. In response to the changing healthcare landscape, New York Presbyterian Hospital has implemented a comprehensive enterprise wide digital health portfolio which includes the first mobile stroke treatment unit on the east coast and the first emergency department-based digital emergency care program in New York City...
December 2017: International Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28644369/european-society-for-pediatric-gastroenterology-hepatology-and-nutrition-s-educational-offer-and-the-training-syllabus
#19
Marco Maglione, Daniela Finizio, Gabor Veres, Tudor L Pop, Grazia I Continisio, Alexandra Papadopoulou, Alfredo Guarino
The basic knowledge necessary for a European pediatric gastroenterologist/hepatologist/nutritionist is set-out in the training syllabus (TS) of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN). We retrospectively compared the topics covered in ESPGHAN's training events between 2013 and 2016 with the basic knowledge TS items. Thirty-six initiatives including e-learning were identified. Twelve (33%) courses focused on gastroenterology, 9 (25%) on hepatology, and 10 (28%) on nutrition...
November 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28642701/the-market-of-biopharmaceutical-medicines-a-snapshot-of-a-diverse-industrial-landscape
#20
Evelien Moorkens, Nicolas Meuwissen, Isabelle Huys, Paul Declerck, Arnold G Vulto, Steven Simoens
Background: Biopharmaceutical medicines represent a growing share of the global pharmaceutical market, and with many of these biopharmaceutical products facing loss of exclusivity rights, also biosimilars may now enter the biopharmaceutical market. Objectives: This study aims to identify and document which investment and development strategies are adopted by industrial players in the global biopharmaceutical market. Methods: A descriptive analysis was undertaken of the investment and development strategies of the top 25 pharmaceutical companies according to 2015 worldwide prescription drug sales...
2017: Frontiers in Pharmacology
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