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https://www.readbyqxmd.com/read/29149142/mapping-the-association-between-vitamin-d-and-low-back-pain-a-systematic-review-and-meta-analysis-of-observational-studies
#1
Joshua Zadro, Debra Shirley, Manuela Ferreira, Ana Paula Carvalho-Silva, Sarah E Lamb, Cyrus Cooper, Paulo H Ferreira
BACKGROUND: Low back pain (LBP) is the highest contributor to disability worldwide, with current intervention strategies only providing small to moderate analgesic effects. The use of vitamin D supplementation for LBP has gained interest due to its proposed anti-inflammatory and neuromodulatory properties. However, it is still unclear whether vitamin D levels differ between those with and without LBP or if vitamin D levels are associated with pain intensity. OBJECTIVES: We aim to investigate the association between vitamin D levels and LBP and to determine if vitamin D levels correlate with pain intensity in individuals with LBP...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29148365/tenacibaculum-insulae-sp-nov-isolated-from-a-tidal-flat
#2
Sooyeon Park, Jeehyun Choi, Su Jung Choi, Jung-Hoon Yoon
A Gram-stain-negative, aerobic, non-motile, non-spore-forming bacterial strain, designated JDTF-31(T), was isolated from a tidal flat in Jindo, a South Korean island. Strain JDTF-31(T) grew optimally at 25 °C and in the presence of 2.0 % (w/v) NaCl. The neighbour-joining phylogenetic tree based on 16S rRNA gene sequences revealed that strain JDTF-31(T) fell within the cluster comprising the type strains of Tenacibaculum species, joining the type strain of Tenacibaculum soleae. The novel strain exhibited 16S rRNA gene sequence similarity values of 98...
November 17, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29146463/age-dependent-in-vitro-metabolism-of-bifenthrin-in-rat-and-human-hepatic-microsomes
#3
Gopinath C Nallani, Appavu Chandrasekaran, Kelem Kassahun, Li Shen, Shaaban F ElNaggar, Zhiwei Liu
Bifenthrin, a pyrethroid insecticide, undergoes oxidative metabolism leading to the formation of 4'-hydroxy-bifenthrin (4'-OH-BIF) and hydrolysis leading to the formation of TFP acid in rat and human hepatic microsomes. In this study, age-dependent metabolism of bifenthrin in rats and humans were determined via the rates of formation of 4'-OH-BIF and TFP acid following incubation of bifenthrin in juvenile and adult rat (PND 15 and PND 90) and human (<5years and >18years) liver microsomes. Furthermore, in vitro hepatic intrinsic clearance (CLint) of bifenthrin was determined by substrate consumption method in a separate experiment...
November 13, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29145330/pathologic-femoral-fracture-due-to-tenofovir-induced-fanconi-syndrome-in-patient-with-chronic-hepatitis-b-a-case-report
#4
You-Sung Suh, Dong-Il Chun, Sung-Woo Choi, Hwan-Woong Lee, Jae-Hwi Nho, Soon-Hyo Kwon, Jae-Ho Cho, Sung Hun Won
RATIONALE: We report a case of a hepatitis B virus (HBV)-positive patient with preexisting bone disease who developed tenofovir-induced Fanconi syndrome and subsequently sustained pathologic fracture. To our best knowledge, this is the first report in the English literature about pathologic femoral fracture due to tenofovir-induced Fanconi syndrome in patient with chronic hepatitis B (CHB). The present report describes detailed our experience with the diagnosis of pathologic femoral fracture due to tenofovir-induced Fanconi syndrome and treatment...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144817/seasonal-variation-of-vitamin-d-and-serum-thyrotropin-levels-and-its-relationship-in-a-euthyroid-caucasian-population
#5
Gautam Das, Peter N Taylor, Heather Javaid, Brian P Tennant, John Geen, Andrew Aldridge, Onyebuchi Okosieme
OBJECTIVES: It is unclear whether seasonal variations in vitamin D concentrations affect the hypothalamo-pituitary-thyroid (HPT) axis. We investigated the seasonal variability of vitamin D and serum thyrotropin (TSH) levels and their inter-relationship. METHODS: Analysis of 401 patients referred with non-specific symptoms of tiredness who had simultaneous measurements of 25(OH)D3 and thyroid function. Patients were categorised according to the season of blood sampling and their vitamin D status...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29144803/endocrine-manifestations-of-primary-hyperoxaluria
#6
Shatha Murad, Yuval Eisenberg
OBJECTIVE: Primary hyperoxaluria type 1 (PH1) is a rare metabolic disorder of oxalate overproduction. It is associated with urolithiasis and nephrocalcinosis which progress to ESRD and systemic oxalosis. As oxalate deposits in tissues, non-parathyroid hormone (nonPTH) mediated hypercalcemia, oxalate osteopathy, primary hypothyroidism and primary hypogonadism develop. In this review, we will present a case of PH1 and provide an overview of this clinical entity and its endocrine manifestations...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29144098/correlation-between-plasmatic-levels-of-vitamin-d-and-pasi-score-our-experience-and-mini-review-of-the-literature
#7
Carlo Mattozzi, Giovanni Paolino, Monica Salvi, Laura Macaluso, Marco Scarno', Gaetano DE Vita, Stefano Calvieri, Antonio G Richetta
BACKGROUND: Psoriasis is a common, inflammatory, chronic, relapsing skin disease. The pathogenesis is multifactorial and it is involved both innate and acquired immunity. Several studies have shown the important role of vitamin D in the pathogenesis of this disorder. In this study we have evaluated a possible correlation between vitamin D and clinical severity of psoriasis calculated with PASI score. METHODS: In this case control study we included 141 Caucasian subjects affected by moderate to severe psoriasis and 62 healthy controls...
November 16, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29143981/high-plasma-25-hydroxyvitamin-d-and-high-risk-of-non-melanoma-skin-cancer-a-mendelian-randomisation-study-of-97849-individuals
#8
U C Winsløw, B G Nordestgaard, S Afzal
BACKGROUND: High plasma 25-hydroxyvitamin D (25 (OH)D) concentration has been associated observationally with high risk of non-melanoma skin cancer, while many studies suggest that vitamin D could have a protective effect on cancer. The true association between vitamin D and risk of skin cancer remains unclear. OBJECTIVES: In this Mendelian randomisation study we tested the hypothesis that genetically high plasma 25(OH)D protects against non-melanoma skin cancer...
November 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29143140/impact-of-conventional-medical-therapy-on-bone-mineral-density-and-bone-turnover-in-adult-patients-with-x-linked-hypophosphatemia-a-6-year-prospective-cohort-study
#9
Vikram Vinod Shanbhogue, Stinus Hansen, Niklas Rye Jørgensen, Signe Sparre Beck-Nielsen
X-linked hypophosphatemia (XLH) is a rare, inheritable disorder manifesting as rickets in children and osteomalacia in adults. While conventional medical treatment with oral phosphate and alfacalcidol is recommended in childhood, it is undecided whether adults should continue therapy. The aim of this 6-year prospective study was to determine the impact of conventional medical treatment on areal bone mineral density (aBMD), bone turnover markers (BTMs) and measures of calcium homeostasis in 27 adult patients with XLH, 11 of whom received medical treatment...
November 15, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29143122/vitamin-d-supplementation-attenuates-oxidative-stress-in-paraspinal-skeletal-muscles-in-patients-with-low-back-pain
#10
Katarzyna Dzik, Wojciech Skrobot, Damian Jozef Flis, Mateusz Karnia, Witold Libionka, Wojciech Kloc, Jan Jacek Kaczor
PURPOSE: The aim of the study was to evaluate markers of oxidative stress and vitamin D receptor in paraspinal muscles in low back pain patients with vitamin D deficiency, with normal level of vitamin D, and after 5 weeks of vitamin D supplementation. METHODS: Patients were divided into three groups: supplemented (SUP) with vitamin D, placebo with normal concentration of vitamin D (SUF), and the placebo group with vitamin D deficiency (DEF). The concentration of serum vitamin D was measured before and after the supplementation with vitamin D (3200 IU/ day for 5 weeks)...
November 15, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29142975/sclerostin%C3%A2-a-debutant-on-the-autosomal-dominant-polycystic-kidney-disease-scene
#11
Magdalena Jankowska, Mathias Haarhaus, Abdul Rashid Qureshi, Bengt Lindholm, Pieter Evenepoel, Peter Stenvinkel
Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disease originating from a mutation in genes encoding polycystin 1 and 2. Recent evidence suggests that these polycystins mediate mechanosensation not only in the primary cilium of kidney cells but also in bone cells. The Wnt/β-catenin signaling pathway plays a central role in mechanotransduction in osteocytes. Mechanical unloading causes the upregulation of the Wnt inhibitor sclerostin. We tested the hypothesis that ADPKD associates with higher circulating sclerostin levels...
May 2017: KI Reports
https://www.readbyqxmd.com/read/29142440/constituents-and-antioxidant-activity-of-bleeding-sap-from-various-xinjiang-grapes
#12
Lv Le, Anwar Umar, Arkin Iburaim, Nicholas Moore
Objective: Wine grape sap or bleeding sap of grapes (GBS) is commonly used in Xinjiang (China) for therapeutic aims. Do variations in composition related to region and variety affect its properties? Methods: GBS samples originating in various parts of Xinjiang (Turpan, Hotan, Kashgar, and Atush) were tested for phenols and polyphenols, polysaccharides, saponin, proteins, individual amino acids, and minerals. Their antioxidant activity was measured using ascorbic acid as reference...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29141976/25-hydroxyvitamin-d-as-a-biomarker-of-vitamin-d-status-and-its-modeling-to-inform-strategies-for-prevention-of-vitamin-d-deficiency-within-the-population
#13
REVIEW
Kevin D Cashman, Ellen Ghm van den Heuvel, Ruud Jw Schoemaker, Damien P Prévéraud, Helen M Macdonald, Jayashree Arcot
There is substantial evidence that the prevalence of vitamin D deficiency is unacceptably high in the population, and this requires action from a public health perspective. Circulating 25-hydroxyvitamin D [25(OH)D] is a robust and reliable marker of vitamin D status and has been used by numerous agencies in the establishment of vitamin D dietary requirements and for population surveillance of vitamin D deficiency or inadequacy. In a wider context, modeling of serum 25(OH)D data and its contributory sources, namely dietary vitamin D supply and UVB availability, can inform our understanding of population vitamin D status...
November 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/29139306/equilibria-kinetics-and-mechanism-for-the-degradation-of-the-cytotoxic-compound-l-n-g-nitroarginine
#14
Pham Van Quyet, Bernice Mei Jin Tan, Celine Valeria Liew, Lai Wah Chan, Quan Sing Ng, Paul Wan Sia Heng
L-N(G)-nitroarginine (LNNA), an analogue of L-arginine, is a competitive inhibitor of nitric oxide synthase which causes the selective reduction of blood flow to tumor cells. Despite the potential of LNNA to function as an adjuvant in cancer therapies, its poor solubility and stability have hindered the development of an injectable formulation of LNNA that is suitable for human administration. This work, for the first time, details a systematic study on the determination of equilibrium Ka constants and the rate law of LNNA degradation...
November 15, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29138535/comparable-pharmacokinetics-and-pharmacodynamics-of-two-epoetin-alfa-formulations-eporon-%C3%A2-and-eprex-%C3%A2-following-a-single-subcutaneous-administration-in-healthy-male-volunteers
#15
Sumin Yoon, Su-Jin Rhee, Sun Ju Heo, Tae Young Oh, Seo Hyun Yoon, Joo-Youn Cho, SeungHwan Lee, Kyung-Sang Yu
Purpose: This study aimed to assess and compare the pharmacokinetic (PK) and pharmacodynamic (PD) properties following a single subcutaneous injection of epoetin alfa (Eporon(®)) with those of the comparator (Eprex(®)) in healthy male subjects. Subjects and methods: A randomized, double-blind, two-sequence, crossover study was conducted. Subjects were randomly assigned to receive a single dose, that is, 4,000 IU, of the test or comparator epoetin alfa. After 4 weeks, all subjects received the alternative formulation...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29137944/reproductive-factors-nutritional-status-and-serum-25-oh-d-levels-in-women-with-breast-cancer-a-case-control-study
#16
REVIEW
Nighat Y Sofi, Monika Jain, Umesh Kapil, Vuthaluru Seenu, Lakshmy R, Chander P Yadav, Ravindra M Pandey, Neha Sareen
The study was conducted with an objective to investigate the association between reproductive factors, nutritional status and serum 25(OH)D levels among women diagnosed with breast cancer (BC). A total of 200 women with BC attending a tertiary healthcare institute of Delhi, India matched with 200 healthy women for age (±2years) and socio economic status were included in the study. Data was collected on socio-demographic profile, reproductive factors, physical activity and dietary intake (24hour dietary recall and food frequency questionnaire) using interviewer administered structured questionnaires and standard tools...
November 11, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29137773/ultrasonic-assisted-synthesis-of-batio3-nanoparticles-at-25%C3%A2-%C3%A2-c-and-atmospheric-pressure
#17
Songkot Utara, Sitchai Hunpratub
Barium titanate (BaTiO3) nanoparticles were successfully synthesized via a sonochemical method (25 kHz) at a constant temperature of 25 °C and atmospheric pressure without a calcination step. Barium hydroxide Ba(OH)2 and diisopropoxytitanium bis(acetylacetonate) (C12H28O6Ti) were used as the starting materials. The effects of the concentration of NaOH used and ultrasonic reaction time were investigated. The phase composition, functional groups and morphology of synthesized powders were characterized using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Fourier transform Raman spectroscopy (FT-Raman) and transmission electron microscopy (TEM)...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137635/the-association-between-serum-25-hydroxyvitamin-d3-concentration-and-serum-lipids-in-the-rural-population-of-china
#18
Huina Ge, Hualei Sun, Teng Wang, Xinxin Liu, Xing Li, Fei Yu, Han Han, Jun Wang, Wenjie Li
BACKGROUND: Vitamin D deficiency is implicated in some diseases, including cardiovascular. Few studies have assessed the correlation between 25-hydroxyvitamin D3 [25(OH) D3] and serum lipids. In this study, we explored the correlation between serum 25(OH) D3 concentrations and serum lipids with a typical sample of the rural population in China. METHODS: Face-to-face research was used to gather some basic information. Fasting serum concentrations of 25-(OH) D3, total cholesterol (TC), triglyceride (TG), HDL cholesterol (HDL-C) and, LDL cholesterol (LDL-C) tested in the laboratory...
November 14, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29137132/maternal-vitamin-d-status-and-the-relationship-with-neonatal-anthropometric-and-childhood-neurodevelopmental-outcomes-results-from-the-seychelles-child-development-nutrition-study
#19
Eamon Laird, Sally W Thurston, Edwin van Wijngaarden, Conrad F Shamlaye, Gary J Myers, Philip W Davidson, Gene E Watson, Emeir M McSorley, Maria S Mulhern, Alison J Yeates, Mary Ward, Helene McNulty, J J Strain
Vitamin D has an important role in early life; however, the optimal vitamin D status during pregnancy is currently unclear. There have been recent calls for pregnant women to maintain circulating 25-hydroxyvitamin D (25(OH)D) concentrations >100 nmol/L for health, yet little is known about the long-term potential benefits or safety of achieving such high maternal 25(OH)D concentrations for infant or child health outcomes. We examined maternal vitamin D status and its associations with infant anthropometric and later childhood neurocognitive outcomes in a mother-child cohort in a sun-rich country near the equator (4...
November 11, 2017: Nutrients
https://www.readbyqxmd.com/read/29136622/serum-transaminase-concentrations-and-the-presence-of-irritable-bowel-syndrome-are-associated-with-serum-25-hydroxy-vitamin-d-concentrations-in-adolescent-girls-who-are-overweight-and-obese
#20
Sayyed Saeid Khayyatzadeh, Hassanali Vatanparast, Amir Avan, Mohammad Bagherniya, Afsane Bahrami, Mohammad Ali Kiani, Hamidreza Bahrami-Taghanaki, Gordon A Ferns, Majid Ghayour-Mobarhan
BACKGROUND/AIMS: Vitamin D deficiency has become endemic globally and its etiology is complex. Few studies have investigated the determinants of serum 25-hydroxy vitamin D (25-OH D). The aim of this study was to investigate the association between lifestyle patterns, liver functional tests (LFTs), and the presence of irritable bowel syndrome (IBS) with serum 25-OH D in apparently healthy girls. METHODS: This cross-sectional study was undertaken in 965 adolescent girls aged 12-18 years...
November 14, 2017: Annals of Nutrition & Metabolism
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