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https://www.readbyqxmd.com/read/28340152/sarcopenia-and-relationships-between-muscle-mass-measured-glomerular-filtration-rate-and-physical-function-in-patients-with-chronic-kidney-disease-stages-3-5
#1
Yunan Zhou, Matthias Hellberg, Philippa Svensson, Peter Höglund, Naomi Clyne
Background.: Sarcopenia and poor physical function are common in patients with chronic kidney disease (CKD). Our aim was to investigate the relationships between muscle mass and measured glomerular filtration rate (GFR) and between muscle mass and strength and balance, respectively, in patients with CKD stages 3-5. Methods.: This is a baseline data analysis of a randomized controlled clinical trial. A total of 148 adult patients with an estimated GFR <30 mL/min/1...
March 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28339929/dietary-resveratrol-supplementation-prevents-transport-stress-impaired-meat-quality-of-broilers-through-maintaining-muscle-energy-metabolism-and-antioxidant-status
#2
C Zhang, L Wang, X H Zhao, X Y Chen, L Yang, Z Y Geng
This experiment was to evaluate the effect of dietary resveratrol (Res) supplementation (0, 400 mg/kg) on growth performance, meat quality, and muscle anaerobic glycolysis and antioxidant capacity of transported broilers. A total of 360 21-day-old male Cobb broilers was randomly allotted to 2 dietary treatments (Res-free group and Res group) with 12 replicates of 15 birds each. On the morning of d 42, after a 9-hour fast, 24 birds (2 birds of each replicate) were selected from the Res-free group and then equally placed into 2 crates, and the other 12 birds (one bird of each replicate) were selected from the Res group and then placed into the other crate...
March 2, 2017: Poultry Science
https://www.readbyqxmd.com/read/28339255/quantum-quenching-of-radiation-losses-in-short-laser-pulses
#3
C N Harvey, A Gonoskov, A Ilderton, M Marklund
Accelerated charges radiate, and therefore must lose energy. The impact of this energy loss on particle motion, called radiation reaction, becomes significant in intense-laser matter interactions, where it can reduce collision energies, hinder particle acceleration schemes, and is seemingly unavoidable. Here we show that this common belief breaks down in short laser pulses, and that energy losses and radiation reaction can be controlled and effectively switched off by appropriate tuning of the pulse length...
March 10, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28335087/ursolic-acid-and-mechanisms-of-actions-on-adipose-and-muscle-tissue-a-systematic-review
#4
REVIEW
Carlos K Katashima, Vagner R Silva, Tatyanne L Gomes, Claude Pichard, Gustavo D Pimentel
This systematic review aimed at addressing the ursolic acid actions as an adjunctive treatment of the obesity-mediated metabolic abnormalities. To explore our aims, we used the literature search including clinical and animal studies using the Medline and Google Scholar (up to December 2015). Out of 63 screened studies, 17 presented eligibility criteria, such as the use of ursolic acid on adiposity, energy expenditure and skeletal muscle mass in mice and humans. In the literature, we found that several physiological and molecular mechanisms are implicated in the effects of ursolic acid on obesity, energy expenditure, hepatic steatosis, skeletal muscle mass loss and physical fitness, such as (1) increase of thermogenesis by modulation adipocyte transcription factors, activation of 5' adenosine monophosphate-activated protein kinase and overexpression of the uncoupling protein 1 thermogenic marker; (2) enhancement of skeletal muscle mass by activation in bloodstream growth hormone and insulin-like growth factor-1 concentrations secretion, as well as in the activation of mammalian target of rapamycin and inhibition of ring-finger protein-1; and (3) improvement of physical fitness by skeletal muscle proliferator-activated receptor gamma co-activator alpha and sirtuin 1 expression...
March 23, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28334646/defluoridation-of-drinking-water-using-a-new-flow-column-electrocoagulation-reactor-fcer-experimental-statistical-and-economic-approach
#5
Khalid S Hashim, Andy Shaw, Rafid Al Khaddar, Montserrat Ortoneda Pedrola, David Phipps
A new batch, flow column electrocoagulation reactor (FCER) that utilises a perforated plate flow column as a mixer has been used to remove fluoride from drinking water. A comprehensive study has been carried out to assess its performance. The efficiency of fluoride removal (R%) as a function of key operational parameters such as initial pH, detention time (t), current density (CD), inter-electrode distance (ID) and initial concentration (C0) has been examined and an empirical model has been developed. A scanning electron microscopy (SEM) investigation of the influence of the EC process on morphology of the surface of the aluminium electrodes, showed the erosion caused by aluminium loss...
March 20, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28334493/glucose-metabolism-in-mammalian-photoreceptor-inner-and-outer-segments
#6
REVIEW
Daniel S Narayan, Glyn Chidlow, John Pm Wood, Robert J Casson
Photoreceptors are the first order neurons of the visual pathway, converting light into electrical signals. Rods and cones are the two main types of photoreceptors in the mammalian retina. Rods are specialized for sensitivity at the expense of resolution and are responsible for vision in dimly lit conditions. Cones are responsible for high acuity central vision and colour vision. Many human retinal diseases are characterized by a progressive loss of photoreceptors. Photoreceptors consist of four primary regions: outer segments, inner segments, cell bodies, and synaptic terminals...
March 23, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28334282/comprehensive-assessment-of-flexible-ligand-docking-algorithms-current-effectiveness-and-challenges
#7
Sheng-You Huang
Protein-ligand docking has been playing an important role in modern drug discovery. To model drug-target binding in real systems, a number of flexible-ligand docking algorithms with different sampling strategies and scoring methods have been subsequently developed over the past three decades, while rigid-ligand docking is still being used because of its compelling computational efficiency. Here, a comprehensive assessment has been conducted to investigate the effectiveness of flexible-ligand docking versus rigid-ligand docking for three representative docking algorithms (global optimization, incremental construction and multi-conformer docking) in virtual screening and pose prediction on the Directory of Useful Decoys...
March 14, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/28333235/ovarian-hormones-and-obesity
#8
Brigitte Leeners, Nori Geary, Philippe N Tobler, Lori Asarian
BACKGROUND: Obesity is caused by an imbalance between energy intake, i.e. eating and energy expenditure (EE). Severe obesity is more prevalent in women than men worldwide, and obesity pathophysiology and the resultant obesity-related disease risks differ in women and men. The underlying mechanisms are largely unknown. Pre-clinical and clinical research indicate that ovarian hormones may play a major role. OBJECTIVE AND RATIONALE: We systematically reviewed the clinical and pre-clinical literature on the effects of ovarian hormones on the physiology of adipose tissue (AT) and the regulation of AT mass by energy intake and EE...
March 2, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28333151/fto-is-required-for-myogenesis-by-positively-regulating-mtor-pgc-1%C3%AE-pathway-mediated-mitochondria-biogenesis
#9
Xiaobo Wang, Ning Huang, Min Yang, Dandan Wei, Haoran Tai, Xiaojuan Han, Hui Gong, Jiao Zhou, Jianqiong Qin, Xiawei Wei, Honghan Chen, Tingting Fang, Hengyi Xiao
Global germ line loss of fat mass- and obesity-associated (FTO) gene results in both the reduction of fat mass and lean mass in mice. The role of FTO in adipogenesis has been proposed, however, that in myogenesis has not. Skeletal muscle is the main component of body lean mass, so its connection with FTO physiologic significance need to be clarified. Here, we assessed the impact of FTO on murine skeletal muscle differentiation by in vitro and in vivo experiments. We found that FTO expression increased during myoblasts differentiation, while the silence of FTO inhibited the differentiation; in addition, skeletal muscle development was impaired in skeletal muscle FTO-deficient mice...
March 23, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28332577/absence-of-role-of-dietary-protein-sensing-in-the-metabolic-benefits-of-duodenal-jejunal-bypass-in-the-mouse
#10
Aude Barataud, Daisy Goncalves, Jennifer Vinera, Carine Zitoun, Adeline Duchampt, Amandine Gautier-Stein, Gilles Mithieux
Roux-en-Y gastric bypass (RYGB) induces remission or substantial improvement of type 2 diabetes mellitus (T2D) but underlying mechanisms are still unclear. The beneficial effects of dietary proteins on energy and glucose homeostasis are mediated by the antagonist effects of peptides toward mu-opioid receptors (MORs), which are highly expressed in the distal gut. We hypothesized that the beneficial effects of RYGB could depend at least in part on the interaction of peptides from food with intestinal MORs. Duodenal-jejunal bypass (DJB) was performed in obese and lean wild-type (WT) or MOR deficient (MOR(-/-)) mice...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28332537/mapping-vibrational-surface-and-bulk-modes-in-a-single-nanocube
#11
Maureen J Lagos, Andreas Trügler, Ulrich Hohenester, Philip E Batson
Imaging of vibrational excitations in and near nanostructures is essential for developing low-loss infrared nanophotonics, controlling heat transport in thermal nanodevices, inventing new thermoelectric materials and understanding nanoscale energy transport. Spatially resolved electron energy loss spectroscopy has previously been used to image plasmonic behaviour in nanostructures in an electron microscope, but hitherto it has not been possible to map vibrational modes directly in a single nanostructure, limiting our understanding of phonon coupling with photons and plasmons...
March 22, 2017: Nature
https://www.readbyqxmd.com/read/28332031/how-do-energy-stores-and-changes-in-these-affect-departure-decisions-by-migratory-birds-a-critical-view-on-stopover-ecology-studies-and-some-future-perspectives
#12
REVIEW
Heiko Schmaljohann, Cas Eikenaar
In birds, accumulating energy is far slower than spending energy during flight. During migration, birds spend, therefore, most of the time at stopover refueling energy used during the previous flight. This elucidates why current energy stores and actual rate of accumulating energy are likely crucial factors influencing bird's decision when to resume migration in addition to other intrinsic (sex, age) and extrinsic (predation, weather) factors modulating the decision within the innate migration program. After first summarizing how energy stores and stopover durations are generally determined, we critically review that high-energy stores and low rates of accumulating energy were significantly related to high departure probabilities in several bird groups...
March 22, 2017: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://www.readbyqxmd.com/read/28331551/environmental-costs-and-benefits-of-growing-miscanthus-for-bioenergy-in-the-uk
#13
REVIEW
Jon P McCalmont, Astley Hastings, Niall P McNamara, Goetz M Richter, Paul Robson, Iain S Donnison, John Clifton-Brown
Planting the perennial biomass crop Miscanthus in the UK could offset 2-13 Mt oil eq. yr(-1), contributing up to 10% of current energy use. Policymakers need assurance that upscaling Miscanthus production can be performed sustainably without negatively impacting essential food production or the wider environment. This study reviews a large body of Miscanthus relevant literature into concise summary statements. Perennial Miscanthus has energy output/input ratios 10 times higher (47.3 ± 2.2) than annual crops used for energy (4...
March 2017: Global Change Biology. Bioenergy
https://www.readbyqxmd.com/read/28331546/increasing-phosphorus-recovery-from-dewatering-centrate-in-microbial-electrolysis-cells
#14
Pengyi Yuan, Younggy Kim
BACKGROUND: Microbial electrolysis cells (MECs) use bioelectrochemical reactions to remove organic contaminants at the bioanode and produce hydrogen gas at the cathode. High local pH conditions near the cathode can also be utilized to produce struvite from nutrient-rich wastewater. This beneficial aspect was investigated using lab-scale MECs fed with dewatering centrate collected at a local wastewater treatment plant. The main objective was to improve phosphorus recovery by examining various cathode configurations and electric current conditions...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28330345/coexistence-of-low-and-high-overlap-phases-in-a-supercooled-liquid-an-integral-equation-investigation
#15
Jean-Marc Bomont, Giorgio Pastore, Jean-Pierre Hansen
The pair structure, free energy, and configurational overlap order parameter Q of an annealed system of two weakly coupled replicas of a supercooled "soft sphere" fluid are determined by solving the hypernetted-chain (HNC) and self-consistent Rogers-Young (RY) integral equations over a wide range of thermodynamic conditions ρ (number-density), T (temperature), and inter-replicas couplings ε12. Analysis of the resulting effective (or Landau) potential W(ρ,T; Q) and of its derivative with respect to Q confirms the existence of a "precursor transition" between weak and strong overlap phases below a critical temperature Tc well above the temperature To of the "ideal glass" transition observed in the limit ε12→0...
March 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28330171/purification-and-characterization-of-endo-%C3%AE-1-4-d-glucanase-from-trichoderma-harzianum-strain-hzn11-and-its-application-in-production-of-bioethanol-from-sweet-sorghum-bagasse
#16
Zabin K Bagewadi, Sikandar I Mulla, Harichandra Z Ninnekar
An acidophilic-solvent-thermostable endo β-1,4-D-glucanase produced from a potential Trichoderma harzianum strain HZN11 was purified to homogeneity by DEAE-Sepharose and Sephadex G-100 chromatography with 33.12 fold purification with specific activity of 66.25 U/mg and molecular mass of ~55 kDa. The optimum temperature and pH were 60 °C and 5.5 retaining 76 and 85 % of activity after 3 h, respectively. It showed stability between pH 4.5-6.0 and temperature between 50-70 °C indicating thermostability...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28329295/flow-dynamics-assessment-of-mitral-valve-surgery-by-intraoperative-vector-flow-mapping
#17
Koichi Akiyama, Naotoshi Nakamura, Keiichi Itatani, Yoshifumi Naito, Mao Kinoshita, Masaru Shimizu, Saeko Hamaoka, Hideya Kato, Hiroaki Yasumoto, Yasufumi Nakajima, Toshiki Mizobe, Satoshi Numata, Hitoshi Yaku, Teiji Sawa
OBJECTIVES: We assessed vortex patterns and energy loss in left ventricular flow in patients who underwent mitral valve repair or replacement with bioprosthetic valves. METHODS: Vector flow mapping was performed before and after the procedure in 15 and 17 patients who underwent repair and replacement, respectively. The preprocedure mitral-septal angle was measured in all patients. Relationships between vortex patterns or energy loss change (ELC) and annuloplasty ring or bioprosthetic valve sizes or the effect of mitral leaflet resection in the repair group were statistically analysed...
February 22, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28329121/very-low-calorie-diets-for-weight-loss-in-obese-older-adults-a-randomized-trial
#18
Cilla J Haywood, Luke A Prendergast, Katrina Purcell, Lauren Le Fevre, Wen Kwang Lim, Mary Galea, Joseph Proietto
Background: Obesity contributes to disability in older adults, and this is offset by weight loss and exercise. Very Low Calorie Diets (VLCDs) achieve rapid weight loss; however, these have not been rigorously evaluated in older people. Methods: A randomized trial was conducted from August 2012 through December 2015. The intervention was 12 weeks of thrice weekly exercise combined with either healthy eating advice (Ex/HE), hypocaloric diet (Ex/Diet), or VLCD (Ex/VLCD)...
February 20, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28328067/diminishing-returns-limit-energetic-costs-of-climate-change
#19
Ofir Levy, Jason D Borchert, Travis W Rusch, Lauren B Buckley, Michael J Angilletta
Changes in the time available for organisms to maintain physiologically preferred temperatures (thermal opportunity) is a primary mechanism by which climate change impacts the fitness and population dynamics of organisms. Yet, it is unclear whether losses or gains in thermal opportunity result in proportional changes in rates of energy procurement and use. We experimentally quantified lizard food consumption and energy assimilation at different durations of thermal opportunity. We incorporated these data in an individual-based model of foraging and digestion in lizards to explore the implications of nonlinear responses to shifts in thermal opportunity across a wide geographic range...
March 22, 2017: Ecology
https://www.readbyqxmd.com/read/28328028/large-area-elemental-imaging-reveals-van-eyck-s-original-paint-layers-on-the-ghent-altarpiece-1432-rescoping-its-conservation-treatment
#20
Geert Van der Snickt, Hélène Dubois, Jana Sanyova, Stijn Legrand, Alexia Coudray, Cécile Glaude, Marie Postec, Piet Van Espen, Koen Janssens
A combination of large-scale and micro-scale elemental imaging, yielding elemental distribution maps obtained by, respectively non-invasive macroscopic X-ray fluorescence (MA-XRF) and by secondary electron microscopy/energy dispersive X-ray analysis (SEM-EDX) and synchrotron radiation-based micro-XRF (SR μ-XRF) imaging was employed to reorient and optimize the conservation strategy of van Eyck's renowned Ghent Altarpiece. By exploiting the penetrative properties of X-rays together with the elemental specificity offered by XRF, it was possible to visualize the original paint layers by van Eyck hidden below the overpainted surface and to simultaneously assess their condition...
March 22, 2017: Angewandte Chemie
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