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https://www.readbyqxmd.com/read/29045254/nutritional-interventions-in-sarcopenia-where-do-we-stand
#1
Jean Woo
PURPOSE OF REVIEW: To document recent evidence regarding the role of nutrition as an intervention for sarcopenia. RECENT FINDINGS: A review of seven randomized controlled trials (RCTs) on beta-hydroxy-beta-methylbutyrate (HMB) alone on muscle loss in 147 adults showed greater muscle mass gain in the intervention group, but no benefit in muscle strength and physical performance measures. Three other review articles examined nutrition and exercise as combined intervention, and suggest enhancement of benefits of exercise by nutrition supplements (energy, protein, vitamin D)...
October 17, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29044829/enzyme-replacement-therapy-prevents-loss-of-bone-and-fat-mass-in-murine-homocystinuria
#2
Tomas Majtan, Insun Park, Erez M Bublil, Jan P Kraus
Skeletal and connective tissue defects are the most striking symptoms in patients suffering from classical homocystinuria (HCU). Here, we determined body composition and bone mass in three mouse models of HCU and assessed whether a long-term administration of enzyme replacement therapy (ERT) corrected the phenotype. The mouse models of HCU were analyzed using dual-energy X-ray absorptiometry and the data were complemented by plasma biochemical profiles. Both the mouse model lacking CBS (KO) and the one expressing human CBS mutant transgene on a mouse CBS null background (I278T) showed marked bone loss and decreased weight mostly due to a lower fat content compared to negative controls...
October 16, 2017: Human Mutation
https://www.readbyqxmd.com/read/29043805/the-mitogen-activated-protein-kinase-kinase-5-regulates-the-proliferation-and-biosynthetic-processes-in-procyclic-forms-of-trypanosoma-brucei
#3
Fernanda G Kugeratski, Michel Batista, Carla Vanessa de Paula Lima, Lisa J Neilson, Elizabeth Sousa da Cunha, Lyris M F de Godoy, Sara Zanivan, Marco Aurelio Krieger, Fabricio K Marchini
The pathogenic protozoan T. brucei alternates into distinct developmental stages in the mammalian and insect hosts. The mitogen-activated protein kinase (MAPK) signaling pathways transduce extracellular stimuli into a range of cellular responses, which ultimately lead to the adaptation to the external environment. Here, we combined a loss of function approach with stable isotope labelling with amino acids in cell culture (SILAC)-based mass spectrometry (MS) to investigate the role of the mitogen-activated kinase kinase 5 (MKK5) in T...
October 18, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29043311/strain-induced-atomic-structure-at-the-ir-doped-laalo3-srtio3-interface
#4
M Lee, R Arras, B Warot-Fonrose, T Hungria, M Lippmaa, H Daimon, M J Casanove
The structure of Ir-doped LaAlO3/SrTiO3(001) interfaces was investigated on the atomic scale using probe-corrected transmission electron microscopy in high-angle annular dark-field scanning mode (HAADF-STEM) and electron energy loss spectroscopy (EELS), combined with first-principles calculations. We report the evolution of the strain state experimentally measured in a 5 unit-cell thick LaAlO3 film as a function of the Ir concentration in the topmost SrTiO3 layer. It is shown that the LaAlO3 layers remain fully elastically strained up to 3% of Ir doping, whereas a higher doping level seems to promote strain relaxation through enhanced cationic interdiffusion...
October 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29042560/mitigating-oxygen-loss-to-improve-the-cycling-performance-of-high-capacity-cation-disordered-cathode-materials
#5
Jinhyuk Lee, Joseph K Papp, Raphaële J Clément, Shawn Sallis, Deok-Hwang Kwon, Tan Shi, Wanli Yang, Bryan D McCloskey, Gerbrand Ceder
Recent progress in the understanding of percolation theory points to cation-disordered lithium-excess transition metal oxides as high-capacity lithium-ion cathode materials. Nevertheless, the oxygen redox processes required for these materials to deliver high capacity can trigger oxygen loss, which leads to the formation of resistive surface layers on the cathode particles. We demonstrate here that, somewhat surprisingly, fluorine can be incorporated into the bulk of disordered lithium nickel titanium molybdenum oxides using a standard solid-state method to increase the nickel content, and that this compositional modification is very effective in reducing oxygen loss, improving energy density, average voltage, and rate performance...
October 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29042142/fat-brain-connections-adipocyte-glucocorticoid-control-of-stress-and-metabolism
#6
Annette D de Kloet, James P Herman
Glucocorticoids act via multiple mechanisms to mobilize energy for in maintenance and restoration of homeostasis. In adipose tissue, glucocorticoids can promote lipolysis and facilitate adipocyte differentiation/growth, serving both energy-mobilizing and restorative processes during negative energy balance. Recent data suggest that adipose-dependent feedback may also be involved in regulation of stress responses. Adipocyte glucocorticoid receptor (GR) deletion causes increased HPA axis stress reactivity, due to a loss of negative feedback signals into the CNS...
October 14, 2017: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/29041549/high-q-factor-with-the-excitation-of-anapole-modes-in-dielectric-split-nanodisk-arrays
#7
Shao-Ding Liu, Zhi-Xing Wang, Wen-Jie Wang, Jing-Dong Chen, Zhi-Hui Chen
The simultaneous realization of high Q-factor resonances and strong near-field enhancements around and inside of dielectric nanostructures is important for many applications in nanophotonics. However, the incident fields are often confined within dielectric nanoparticles, which results in poor optical interactions with external environment. Near-field enhancements can be extended outside of dielectric nanostructures with proper design, but the Q-factor is often reduced caused by additional radiation losses...
September 18, 2017: Optics Express
https://www.readbyqxmd.com/read/29041503/dual-band-and-polarization-independent-infrared-absorber-based-on-two-dimensional-black-phosphorus-metamaterials
#8
Jiao Wang, Yannan Jiang, Zhirun Hu
Two-dimensional (2D) black phosphorus (BP) with direct band gap, bridges the characteristics of graphene with a zero or near-zero band gap and transition metal dichalcogenides with a wide band gap. In the infrared (IR) regime, 2D BP materials can attenuate electromagnetic energy due to losses derived from its surface conductivity. This paper proposes an IR absorber based on 2D BP metamaterials. It consists of multi-layer BP-based nano-ribbon pairs, each formed by two orthogonally stacked nano-ribbons. The multi-layer BP metamaterials and bottom gold mirror together form a Fabry-Perot resonator that could completely inhibit light transmission to create strong absorption through the BP metamaterials...
September 4, 2017: Optics Express
https://www.readbyqxmd.com/read/29041256/polaritonic-figure-of-merit-of-plane-structures
#9
Jose Ordonez-Miranda, Younès Ezzahri, Laurent Tranchant, Jérémie Drevillon, Sergei Gluchko, Karl Joulain, Sebastian Volz
Based on the ability of plane structures to simultaneously optimize the propagation, confinement, and energy of surface plasmon-polaritons or surface phonon-polaritons, we develop the polaritonic figure of merit Z = βRΛ(2)/δ, where βR, Λ and δ are the longitudinal wave vector, propagation length, and penetration depth, respectively. Explicit and analytical expressions of Z are derived for a single interface and a suspended thin film, as functions of the material permittivities and the film thickness. Higher Z are obtained for thinner films and smaller energy losses...
October 16, 2017: Optics Express
https://www.readbyqxmd.com/read/29041099/nanostructured-antireflective-in-plane-solar-harvester
#10
Jared Tippens, Abhijeet Bagal, Xu A Zhang, Chih-Hao Chang
In this work, we demonstrate a two-dimensional nano-hole array that can reduce reflection losses while passively trapping and harvesting incident light. The surface structure is designed to scavenge a small portion of incident light that would typically be lost due to Fresnel reflection, while the majority of light transmits unobstructed like a regular window. The trapping mechanism is dependent on angle and wavelength, and can be designed to selectively trap narrow wavelength bands using the constructed theoretical models...
August 7, 2017: Optics Express
https://www.readbyqxmd.com/read/29041049/full-spectrum-light-management-by-pseudo-disordered-moth-eye-structures-for-thin-film-solar-cells
#11
Xiaojun Liu, Yun Da, Yimin Xuan
In this paper, the role of pseudo-disordered moth-eye structures on the optical features for application to thin-film solar cells is investigated to realize the superior light management for the full-spectrum solar energy utilization, compared with some ordered structures. Without loss of generality, the c-Si thin film solar cell is taken as the example. The results demonstrate that the fluctuations introduced into the geometry parameters of moth-eye elements can lead to the remarkable absorption enhancement in the wavelength region of 0...
August 7, 2017: Optics Express
https://www.readbyqxmd.com/read/29041038/optical-analysis-of-a-iii-v-nanowire-array-on-si-dual-junction-solar-cell
#12
Yang Chen, Oliver Höhn, Nico Tucher, Mats-Erik Pistol, Nicklas Anttu
A tandem solar cell consisting of a III-V nanowire subcell on top of a planar Si subcell is a promising candidate for next generation photovoltaics due to the potential for high efficiency. However, for success with such applications, the geometry of the system must be optimized for absorption of sunlight. Here, we consider this absorption through optics modeling. Similarly, as for a bulk dual-junction tandem system on a silicon bottom cell, a bandgap of approximately 1.7 eV is optimum for the nanowire top cell...
August 7, 2017: Optics Express
https://www.readbyqxmd.com/read/29040734/geometrical-efficiency-of-plane-parallel-ionization-chambers-in-proton-scanning-beam
#13
N Mojzeszek, M Klodowska, W Komenda, L Stolarczyk, R Kopec, P Olko
For commissioning of a proton therapy unit depth dose distributions must be determined and introduced into the Treatment Planning System. In pencil beam scanning (PBS) technique, integral depth dose (IDD) acquisition should be performed with detector large enough to ensure entire beam laterally broadened by scattered and secondary contributions. The purpose of this article is to quantify, using measurements and Monte Carlo transport calculations, the ionization chamber's (IC) geometrical efficiency versus the chamber radius and proton beam energy...
October 11, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29040301/surveying-predictors-of-late-life-longitudinal-change-in-daily-activity-energy-expenditure
#14
Vincenzo Valiani, Sandrine Sourdet, Dale A Schoeller, Dawn C Mackey, Douglas C Bauer, Nancy W Glynn, Yosuke Yamada, Tamara B Harris, Todd M Manini
BACKGROUND: Total daily energy expenditure (TEE) is composed of resting metabolic rate (RMR), post-prandial thermogenesis and activity energy expenditure (AEE). Higher AEE is strongly associated with lower mortality and physical limitations among older adults, but factors that predict changes in AEE in septu and octogenarians are not clearly understood. OBJECTIVE: To identify factors associated with late-life longitudinal change in AEE. DESIGN: Energy expenditure was re-assessed in 83 participants (average age at baseline, 74...
2017: PloS One
https://www.readbyqxmd.com/read/29039743/bioactivity-and-cell-compatibility-of-%C3%AE-wollastonite-derived-from-rice-husk-ash-and-limestone
#15
Roslinda Shamsudin, Farah 'Atiqah Abdul Azam, Muhammad Azmi Abdul Hamid, Hamisah Ismail
The aim of this study was to prepare β-wollastonite using a green synthesis method (autoclaving technique) without organic solvents and to study its bioactivity. To prepare β-wollastonite, the precursor ratio of CaO:SiO₂ was set at 55:45. This mixture was autoclaved for 8 h and later sintered at 950 °C for 2 h. The chemical composition of the precursors was studied using X-ray fluorescence (XRF), in which rice husk ash consists of 89.5 wt % of SiO₂ in a cristobalite phase and calcined limestone contains 97...
October 17, 2017: Materials
https://www.readbyqxmd.com/read/29038509/optimal-formula-see-text-symmetric-switch-features-exceptional-point
#16
Anatole Lupu, Vladimir V Konotop, Henri Benisty
We consider the optimization problem of least energy-cost path in open systems that are described by non-Hermitian Hamiltonians. We apply it to find the optimal gain-loss profile for a non-uniform PT-symmetric coupler performing a binary transfer function. We bring evidence that the gain-loss profile fulfilling this requirement corresponds to a non-conventional situation where light intensity is conserved at every point along the PT-symmetric system. Besides, we find that the optimal profile corresponds to a practically important case of optical switching operation achieved with minimal amount of aggregate amplification level...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29038293/loss-of-hepatic-amp-activated-protein-kinase-impedes-the-rate-of-glycogenolysis-but-not-gluconeogenic-fluxes-in-exercising-mice
#17
Curtis C Hughey, Freyja D James, Deanna P Bracy, E Patrick Donahue, Jamey D Young, Benoit Viollet, Marc Foretz, David H Wasserman
Pathologies including diabetes and conditions such as exercise place an unusual demand on liver energy metabolism, and this demand induces a state of energy discharge. Hepatic AMP-activated protein kinase (AMPK) has been proposed to inhibit anabolic processes such as gluconeogenesis in response to cellular energy stress. However, both AMPK activation and glucose release from the liver are increased during exercise. Here, we sought to test the role of hepatic AMPK in the regulation of in vivo glucose producing and citric acid cycle-related fluxes during an acute bout of muscular work...
October 16, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29037389/lower-critical-temperature-and-cold-induced-thermogenesis-of-lean-and-overweight-humans-are-inversely-related-to-body-mass-and-basal-metabolic-rate
#18
Kimberly J Nahon, Mariëtte R Boon, Fleur Doornink, Ingrid M Jazet, Patrick C N Rensen, Gustavo Abreu-Vieira
It is colloquially stated that body size plays a role in the human response to cold, but the magnitude and details of this interaction are unclear. To explore the inherent influence of body size on cold-exposed metabolism, we investigated the relation between body composition and resting metabolic rate in humans at thermoneutrality and during cooling within the nonshivering thermogenesis range. Body composition and resting energy expenditure were measured in 20 lean and 20 overweight men at thermoneutrality and during individualized cold exposure...
October 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29037093/less-periprosthetic-bone-loss-following-the-anterolateral-approach-to-the-hip-compared-with-the-direct-lateral-approach
#19
Terje O Ugland, Glenn Haugeberg, Svein Svenningsen, Stein H Ugland, Øystein H Berg, Are Hugo Pripp, Lars Nordsletten
Background and purpose - The loss of bone mineral in the proximal femur following hip arthroplasty may increase the fracture risk around uncemented stems. We hypothesized that the surgical approach to the hip might influence bone mineral changes around the femoral stem in patients with a femoral neck fracture (FNF). Patients and methods - This was a pre-specified subgroup analysis (n = 51) of an ongoing randomized trial (n = 120) in patients with FNF. Participants were allocated to an uncemented hemiarthroplasty inserted through a direct lateral (Hardinge) approach or an anterolateral (modified Watson-Jones) approach...
October 17, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/29036856/informal-care-employment-and-quality-of-life-barriers-and-facilitators-to-combining-informal-care-and-work-participation-for-healthcare-professionals
#20
Eveline Heitink, Yvonne Heerkens, Josephine Engels
BACKGROUND: In The Netherlands, one out of six Dutch employees has informal care tasks; in the hospital and healthcare sector, this ratio is one out of four workers. Informal carers experience problems with the combination of work and informal care. In particular, they have problems with the burden of responsibility, a lack of independence and their health. These problems can reveal themselves in a variety of mental and physical symptoms that can result in absenteeism, reduction or loss of (work) participation, reduction of income, and even social isolation...
October 8, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
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