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https://www.readbyqxmd.com/read/28535124/serum-creatinine-and-cystatin-c-provide-conflicting-evidence-of-acute-kidney-injury-following-acute-ingestion-of-potassium-permanganate-and-oxalic-acid
#1
Thilini Madushanka Wijerathna, Indika Bandara Gawarammana, Dhammika Menike Dissanayaka, Chathura Palanagasinghe, Fathima Shihana, Gihani Dassanayaka, Seyed Shahmy, Zoltan Huba Endre, Fahim Mohamed, Nicholas Alan Buckley
AIM: Acute kidney injury (AKI) is common following deliberate self-poisoning with a combination washing powder containing oxalic acid (H2C2O4) and potassium permanganate (KMnO4). Early and rapid increases in serum creatinine (sCr) follow severe poisoning. We investigated the relationship of these increases with direct nephrotoxicity in an ongoing multicenter prospective cohort study in Sri Lanka exploring AKI following poisoning. METHODS: Multiple measures of change in kidney function were evaluated in 48 consenting patients who had serial sCr and serum cystatin C (sCysC) data available...
May 23, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28534839/exploring-the-pivotal-role-of-the-ck2-hinge-region-sub-pocket-in-binding-with-tricyclic-quinolone-analogues-by-computational-analysis
#2
Yue Zhou, Na Zhang, Shan Tang, Xiaoqian Qi, Lijiao Zhao, Rugang Zhong, Yongzhen Peng
Protein kinase CK2 has been considered as an attractive therapeutic target of cancer therapy. The tricyclic quinoline compound CX-4945 is the first representative of CK2 inhibitors used in human clinical trials. The binding of non-2,6-naphtyridine substituted compounds 27e (IC50 > 500 nM) and 27h (IC50 > 1000 nM) to CK2 is abolished. However, the unbinding mechanisms due to the key pharmacophore group replacement of compounds 27e and 27h are unveiled. In the present work, combined computational analysis was performed to investigate the underlying structural basis of the low-affinity of two systems...
May 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28534733/acute-acoustic-trauma-among-soldiers-during-an-intense-combat
#3
Noam Yehudai, Nir Fink, Manor Shpriz, Tal Marom
BACKGROUND: During military actions, soldiers are constantly exposed to various forms of potentially harmful noises. Acute acoustic trauma (AAT) results from an impact, unexpected intense noise ≥140 dB, which generates a high-energy sound wave that can damage the auditory system. PURPOSE: We sought to characterize AAT injuries among military personnel during operation "Protective Edge," to analyze the effectiveness of hearing protection devices (HPDs), and to evaluate the benefit of steroid treatment in early-diagnosed AAT injury...
May 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28534703/chlorhexidine-and-silver-sulfadiazine-coating-on-central-venous-catheters-is-not-sufficient-for-protection-against-catheter-related-infection-simulation-based-laboratory-research-with-clinical-validation
#4
Yoon Ji Choi, Jae Kwan Lim, Jeong Jun Park, Hyub Huh, Dong-Joo Kim, Chang-Hoon Gong, Seung Zhoo Yoon
Objective The efficacy of chlorhexidine- and silver sulfadiazine-coated central venous catheters (CSS-CVC) against catheter-related infection remains controversial. We hypothesized that the loss of silver nanoparticles may reduce the antibacterial efficacy of CSS-CVCs and that this loss could be due to the frictional force between the surface of the CVC and the bloodstream. The objective of this study was to investigate whether the antimicrobial effect of CSS-CVCs decreases with increasing exposure time in a bloodstream model and quantitatively assay the antimicrobial effect of CSS-CVCs compared with polyurethane and antiseptic-impregnated CVCs...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28534146/detection-of-glass-particles-on-bone-lesions-using-sem-eds
#5
Romain Montoriol, Céline Guilbeau-Frugier, Elodie Chantalat, Mathieu Roumiguié, Marie-Bernadette Delisle, Bruno Payré, Norbert Telmon, Frédéric Savall
The problem of identifying the wounding agent in forensic cases is recurrent. Moreover, when several tools are involved, distinguishing the origin of lesions can be difficult. Scanning electron microscopy (SEM)/energy dispersive X-ray analysis (EDS) equipment is increasingly available to the scientific and medical community, and some studies have reported its use in forensic anthropology. However, at our knowledge, no study has reported the use of SEM-EDS in forensic cases involving glass tools, whether in case reports or experiments...
May 23, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28533263/prior-weight-loss-exacerbates-the-biological-drive-to-gain-weight-after-the-loss-of-ovarian-function
#6
Vanessa D Sherk, Matthew R Jackman, Erin D Giles, Janine A Higgins, Rebecca M Foright, David M Presby, Ginger C Johnson, Julie A Houck, Jordan L Houser, Robera Oljira, Paul S MacLean
Both the history of obesity and weight loss may change how menopause affects metabolic health. The purpose was to determine whether obesity and/or weight loss status alters energy balance (EB) and subsequent weight gain after the loss of ovarian function. Female lean and obese Wistar rats were randomized to 15% weight loss (WL) or ad libitum fed controls (CON). After the weight loss period, WL rats were kept in EB at the reduced weight for 8 weeks prior to ovariectomy (OVX). After OVX, all rats were allowed to eat ad libitum until weight plateaued...
May 2017: Physiological Reports
https://www.readbyqxmd.com/read/28531772/diet-induced-weight-loss-and-markers-of-endothelial-dysfunction-and-inflammation-in-treated-patients-with-type-2-diabetes
#7
K A Berk, T P Oudshoorn, A J M Verhoeven, M T Mulder, A J M Roks, W A Dik, R Timman, E J G Sijbrands
BACKGROUND & AIMS: Overweight and obesity increase cardiovascular mortality in patients with type 2 diabetes (T2D). In a recent trial, however, diet-induced weight loss did not reduce the cardiovascular risk of patients with T2D, possibly due to the parallel intensive medical treatment. We investigated the effect of diet-induced weight loss on cardiovascular risk factors in overweight and obese patients with T2D, and whether this effect was influenced by the use of statins, ACE inhibitors, metformin and duration of T2D...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531563/what-do-individuals-with-morbid-obesity-report-as-a-usual-dietary-intake-a-narrative-review-of-available-evidence
#8
Cathy M Harbury, Elisabeth E Verbruggen, Robin Callister, Clare E Collins
BACKGROUND: In several developed countries, as obesity prevalence doubles it has quadrupled for morbid obesity (BMI ≥ 40 kgm(-2)). As more individuals with morbid obesity present for weight loss treatment there is a greater need to understand their dietary habits. No reviews were found in the literature, therefore this systematic review aims to identify and describe the existing evidence on the usual dietary intake of individuals with morbid obesity including those from a general population and those seeking treatment such as weight loss surgery...
June 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531392/a-randomised-controlled-feasibility-and-proof-of-concept-trial-in-delayed%C3%A2-gastric-emptying-when-metoclopramide-fails-we-should-revisit%C3%A2-nasointestinal-feeding-versus-dual-prokinetic-treatment-achieving-goal-nutrition-in-critical-illness-and-delayed-gastric
#9
Stephen J Taylor, Kaylee Allan, Helen McWilliam, Alex Manara, Jules Brown, Rosemary Greenwood, Deirdre Toher
BACKGROUND & AIMS: Delayed gastric emptying (DGE) commonly limits the use of enteral nutrition (EN) and may increase ventilator-associated pneumonia. Nasointestinal feeding has not been tested against dual prokinetic treatment (Metoclopramide and Erythromycin) in DGE refractory to metoclopramide. This trial tests the feasibility of recruiting this 'treatment-failed' population and the proof of concept that nasointestinal (NI) feeding can increase the amount of feed tolerated (% goal) when compared to nasogastric (NG) feeding plus metoclopramide and erythromycin treatment...
August 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531299/pain-energy-model-of-mobility-limitation-in-the-older-adult
#10
Peter C Coyle, Jennifer A Schrack, Gregory E Hicks
Background. : Chronic pain is prevalent, costly, and disabling among older adults. Although mobility decline is inevitable with aging, it is clear, from current evidence, that older adults with chronic pain experience a greater rate of functional mobility decline than their pain-free peers. Past studies suggest that pain expedites the age-related decline in functional mobility; however, the pathways through which pain affects mobility remain unclear. Gerontological experts hypothesize that the age-related decline in mobility may be driven by alterations in energy expenditure; these concepts are outlined in a model known as the Energetic Pathway of Mobility Loss...
May 22, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28531108/regulation-of-metabolic-activity-by-p53
#11
REVIEW
Jessica Flöter, Irem Kaymak, Almut Schulze
Metabolic reprogramming in cancer cells is controlled by the activation of multiple oncogenic signalling pathways in order to promote macromolecule biosynthesis during rapid proliferation. Cancer cells also need to adapt their metabolism to survive and multiply under the metabolically compromised conditions provided by the tumour microenvironment. The tumour suppressor p53 interacts with the metabolic network at multiple nodes, mostly to reduce anabolic metabolism and promote preservation of cellular energy under conditions of nutrient restriction...
May 20, 2017: Metabolites
https://www.readbyqxmd.com/read/28530498/negative-consequences-of-low-energy-availability-in-natural-male-bodybuilding-a-review
#12
Petter Fagerberg
Energy availability (EA) is a scientific concept describing how much energy is available for basic metabolic functions such as reproduction, immunity and skeletal homeostasis. Carefully controlled studies on women have shown pathological effects of EA<30kcal/kg fat free mass (FFM) and this state has been labeled low EA (LEA). Bodybuilding is a sport in which athletes compete to show muscular definition, symmetry and low body fat. The process of contest preparation in bodybuilding includes months of underfeeding, thus increasing the risk of LEA and its negative health consequences...
May 22, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/28530181/green-synthesis-of-cuo-nanoparticles-loaded-on-the-seashell-surface-using-rumex-crispus-seeds-extract-and-its-catalytic-applications-for-reduction-of-dyes
#13
Akbar Rostami-Vartooni
In this study, CuO nanoparticles supported on the seashell (CuO NPs/seashell) was prepared using Rumex crispus seeds extract as a chelating and capping agent. The prepared nanocomposite was characterised by Fourier transform infrared spectroscopy, X-ray diffraction, field emission scanning electron microscopy, energy-dispersive X-ray spectroscopy and transmission electron microscopy. The particle size of CuO NPs on the seashell sheets was in the range of 8-60 nm. Catalytic ability of CuO NPs/seashell was investigated for the reduction of 4-nitrophenol (4-NP) and Congo red (CR)...
June 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28528893/body-temperature-responses-to-handling-stress-in-wintering-black-capped-chickadees-poecile-atricapillus-l
#14
Agnès Lewden, Andreas Nord, Magali Petit, François Vézina
Body temperature variation in response to acute stress is typically characterized by peripheral vasoconstriction and a concomitant increase in core body temperature (stress-induced hyperthermia). It is poorly understood how this response differs between species and within individuals of the same species, and how it is affected by the environment. We therefore investigated stress-induced body temperature changes in a non-model species, the Black-capped Chickadee, in two environmental conditions: outdoors in low ambient temperature (mean: -6...
May 18, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28527951/digital-food-photography-technology-improves-efficiency-and-feasibility-of-dietary-intake-assessments-in-large-populations-eating-ad-libitum-in-collective-dining-facilities
#15
Holly L McClung, Catherine M Champagne, H Raymond Allen, Susan M McGraw, Andrew J Young, Scott J Montain, Aaron P Crombie
BACKGROUND: Accurate assessment of dietary intake continues to challenge researchers, especially in field, or non-laboratory settings. OBJECTIVE: In this study, digital food photography (DFP) methodology was used to assess nutritional intake (NI) of Soldiers participating in the US Army's Ranger Selection and Assessment Program (RASP). METHODS: During this high-intensity six-week course, Soldiers complete simulated operational missions, perform various military tasks, and importantly, eating time is severely limited...
May 17, 2017: Appetite
https://www.readbyqxmd.com/read/28527629/p62-sequestosome-1-knockout-delays-neurodegeneration-induced-by-drp1-loss
#16
Tatsuya Yamada, Yoshihiro Adachi, Toru Yanagawa, Miho Iijima, Hiromi Sesaki
Purkinje neurons, one of the largest neurons in the brain, are critical for controlling body movements, and the dysfunction and degeneration of these cells cause ataxia. Purkinje neurons require a very efficient energy supply from mitochondria because of their large size and extensive dendritic arbors. We have previously shown that mitochondrial division mediated by dynamin-related protein 1 (Drp1) is critical for the development and survival of Purkinje neurons. Drp1 deficiency has been associated with one of the major types of ataxia: autosomal recessive spastic ataxia of Charlevoix Saguenay...
May 17, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28527581/nuclear-receptors-in-skeletal-homeostasis
#17
Hao Zuo, Yihong Wan
Nuclear receptors are a family of transcription factors that can be activated by lipophilic ligands. They are fundamental regulators of development, reproduction, and energy metabolism. In bone, nuclear receptors enable bone cells, including osteoblasts, osteoclasts, and osteocytes, to sense their dynamic microenvironment and maintain normal bone development and remodeling. Our views of the molecular mechanisms in this process have advanced greatly in the past decade. Drugs targeting nuclear receptors are widely used in the clinic for treating patients with bone disorders such as osteoporosis by modulating bone formation and resorption rates...
2017: Current Topics in Developmental Biology
https://www.readbyqxmd.com/read/28527105/association-between-lumbar-bone-mineral-density-and-serum-uric-acid-in-postmenopausal-women-a-cross-sectional-study-of-healthy-chinese-population
#18
Wen Han, Xiaojuan Bai, Nan Wang, Lulu Han, Xuefeng Sun, Xiangmei Chen
Partial correlation and regression analyses were used in this study. We showed that there is a linear relationship between bone mineral density and serum uric acid within the normal physiologic range, and higher serum uric acid levels had a protective effect on bone loss in postmenopausal osteoporosis. PURPOSE: The significance of the relationship between lumbar bone mineral density (()BMD) and serum uric acid (SUA) levels is unclear. The aims of this study were to investigate on a population-level the association between lumbar BMD and SUA within the normal physiologic range and to determine whether SUA plays a protective role in bone loss in healthy postmenopausal Chinese women...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28526530/insights-into-the-early-stage-of-pinus-nigra-arn-somatic-embryogenesis-using-discovery-proteomics
#19
Katarína Klubicová, Lubica Uvácková, Maksym Danchenko, Peter Nemecek, Ludovít Skultéty, Ján Salaj, Terézia Salaj
The somatic embryogenesis in conifers represents a suitable model of plant regeneration system facilitating studies of fundamental aspects of an early development as well as in vitro micropropagation. The aim of our study was to deeper understand the somatic embryogenesis in the conifer tree Pinus nigra Arn. Comparative proteomic analysis based on 2D-PAGE in 1) proliferating embryogenic tissues (E) initiated from immature zygotic embryos, 2) non-embryogenic calli (NEC) initiated from cotyledons of somatic seedlings of the same genotypes, 3) embryogenic tissues that lost the maturation capacity (E-L) of two cell lines (E362, E366)...
May 16, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28526377/orange-juice-allied-to-a-reduced-calorie-diet-results-in-weight-loss-and-ameliorates-obesity-related-biomarkers-a-randomized-controlled-trial
#20
Carolina Ribeiro, Grace Dourado, Thais Cesar
OBJECTIVE: Assumptions have linked orange juice (OJ) consumption with weight gain and adverse effects on health due to its sugar content; however, epidemiologic studies have not shown increased risk for overweight or obesity with the consumption of 100% OJ. The aim of this study was to verify whether the combination of a reduced-calorie diet (RCD) and 100% OJ contribute to weight loss, promote changes in glucose and lipid metabolism, and improve diet quality in obese individuals. METHODS: A randomized controlled trial with 78 obese patients (age 36 ± 1 y, body mass index [BMI] 33 ± 3 kg/m(2)) were enrolled in two groups: Individuals in the OJ group submitted to an RCD that included OJ (500 mL/d), and individuals in the control group submitted to an RCD without OJ...
June 2017: Nutrition
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