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Component resolved diagnostics

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https://www.readbyqxmd.com/read/28346705/performance-of-a-polymer-coated-silicon-microarray-for-simultaneous-detection-of-food-allergen-specific-ige-and-igg4
#1
Steven Sievers, Marina Cretich, Paola Gagni, Birgit Ahrens, Galina Grishina, Hugh Sampson, Bodo Niggemann, Marcella Chiari, Kirsten Beyer
BACKGROUND: Microarray-based component-resolved diagnostics (CRD) has become an accepted tool to detect allergen specific IgE-sensitization towards hundreds of allergens in parallel from one drop of serum. Nevertheless specificity and sensitivity as well as a simultaneous detection of allergen specific IgG4, as a potential parameter for tolerance development, remain to be optimized. OBJECTIVE: We applied the recently introduced silicon chip coated with a functional polymer named copoly(DMA-NAS-MAPS) to the simultaneous detection of food allergen specific IgE and IgG4, and compared it with ImmunoCAP and ImmunoCAP ISAC...
March 27, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28341528/molecular-diagnosis-of-allergy-to-anisakis-simplex-and-gymnorhynchus-gigas-fish-parasites
#2
A Armentia, J Santos, Z Serrano, B Martín, S Martín, J Barrio, S Fernández, M González-Sagrado, F Pineda, R Palacios
BACKGROUND: There has been an increase in the prevalence of hypersensitivity to Anisakis simplex. There are fish parasites other than Anisakis simplex whose allergenicity has not yet been studied. OBJECTIVE: To assess IgE hypersensitivity caused by fish parasite allergens in patients with gastro-allergic symptoms after consumption of fish, shellfish or cephalopods, compared with healthy subjects, pollen allergic individuals and children with digestive symptoms after eating marine food...
March 21, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28285847/japanese-guidelines-for-food-allergy-2017
#3
REVIEW
Motohiro Ebisawa, Komei Ito, Takao Fujisawa
Five years have passed since the Japanese Pediatric Guideline for Food Allergy (JPGFA) was first revised in 2011 from its original version. As many scientific papers related to food allergy have been published during the last 5 years, the second major revision of the JPGFA was carried out in 2016. In this guideline, food allergies are generally classified into four clinical types: (1) neonatal and infantile gastrointestinal allergy, (2) infantile atopic dermatitis associated with food allergy, (3) immediate-type of food allergy (urticaria, anaphylaxis, etc...
March 9, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28243098/delirium-after-a-traumatic-brain-injury-predictors-and-symptom-patterns
#4
Jutaporn Maneewong, Benchalak Maneeton, Narong Maneeton, Tanat Vaniyapong, Patrinee Traisathit, Natthanidnan Sricharoen, Manit Srisurapanont
BACKGROUND: Delirium in traumatic brain injury (TBI) is common, may be predictable, and has a multifaceted symptom complex. This study aimed to examine: 1) the sum score of Glasgow Coma Scale (GCS) and if its component scores could predict delirium in TBI patients, and 2) the prominent symptoms and their courses over the first days after TBI. METHODS: TBI patients were recruited from neurosurgical ward inpatients. All participants were hospitalized within 24 hours after their TBI...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28184046/investigating-the-accuracy-risk-impact-and-cost-effectiveness-of-component-resolved-diagnostic-test-for-food-allergy-a-systematic-review-protocol
#5
Javier Flores Kim, Bright I Nwaru, Nicola McCleary, Andrew Stoddart, Aziz Sheikh
No abstract text is available yet for this article.
December 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28137276/towards-standardization-of-next-generation-sequencing-of-ffpe-samples-for-clinical-oncology-intrinsic-obstacles-and-possible-solutions
#6
Maxim Ivanov, Konstantin Laktionov, Valery Breder, Polina Chernenko, Ekaterina Novikova, Ekaterina Telysheva, Sergey Musienko, Ancha Baranova, Vladislav Mileyko
BACKGROUND: Next generation sequencing has a potential to revolutionize the management of cancer patients within the framework of precision oncology. Nevertheless, lack of standardization decelerated entering of the technology into the clinical testing space. Here we dissected a number of common problems of NGS diagnostics in oncology and introduced ways they can be resolved. METHODS: DNA was extracted from 26 formalin fixed paraffin embedded (FFPE) specimens and processed with the TrueSeq Amplicon Cancer Panel (Illumina Inc, San Diego, California) targeting 48 cancer-related genes and sequenced in single run...
January 31, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28101431/non-invasive-terahertz-imaging-of-tissue-water-content-for-flap-viability-assessment
#7
Neha Bajwa, Joshua Au, Reza Jarrahy, Shijun Sung, Michael C Fishbein, David Riopelle, Daniel B Ennis, Tara Aghaloo, Maie A St John, Warren S Grundfest, Zachary D Taylor
Accurate and early prediction of tissue viability is the most significant determinant of tissue flap survival in reconstructive surgery. Perturbation in tissue water content (TWC) is a generic component of the tissue response to such surgeries, and, therefore, may be an important diagnostic target for assessing the extent of flap viability in vivo. We have previously shown that reflective terahertz (THz) imaging, a non-ionizing technique, can generate spatially resolved maps of TWC in superficial soft tissues, such as cornea and wounds, on the order of minutes...
January 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28092637/non-invasive-classification-of-breast-microcalcifications-using-x-ray-coherent-scatter-computed-tomography
#8
Bahaa Ghammraoui, Lucretiu M Popescu
We investigate the use of energy dispersive x-ray coherent scatter computed tomography (ED-CSCT) as a non-invasive diagnostic method to differentiate between type I and type II breast calcifications. This approach is sensitive to the differences of composition and internal crystal structure of different types of microcalcifications. The study is carried out by simulating a CSCT system with a scanning pencil beam, considering a polychromatic x-ray source and an energy-resolving photon counting detector. In a first step, the multidimensional angle and energy distributed CSCT data is reduced to the projection-space distributions of only a few components, corresponding to the expected target composition: adipose, glandular tissue, weddellite (calcium oxalate) for type I calcifications, and hydroxyapatite for type II calcifications...
February 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28060371/basaloid-blue-salivary-gland-tumors
#9
Raja R Seethala
Basaloid tumors are a common diagnostic problem in salivary gland pathology. However, delineating each of these tumor types is facilitated by an algorithmic approach incorporated by tumor border and cell types. This approach greatly diminishes the challenge of separating polymorphous low-grade adenocarcinoma (PLGA) from adenoid cystic carcinoma (ACC). Despite the overlap in growth pattern, ACC is biphasic while PLGA is not. More relevant challenges, namely differentiation of the biphasic basaloid neoplasms including: epithelial-myoepithelial carcinoma (EMCA), cellular pleomorphic adenoma (PA), basal cell adenoma (BCA), and basal cell adenocarcinoma (BCAC), are resolved by a combination of morphologic, immunophenotypic, and to a limited extent, molecular features...
January 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28048371/we-g-209-01-digital-radiography
#10
B Schueler
Digital radiography, CT, PET, and MR are complicated imaging modalities which are composed of many hardware and software components. These components work together in a highly coordinated chain of events with the intent to produce high quality images. Acquisition, processing and reconstruction of data must occur in a precise way for optimum image quality to be achieved. Any error or unexpected event in the entire process can produce unwanted pixel intensities in the final images which may contribute to visible image artifacts...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047725/we-g-209-02-ct
#11
J Kofler
Digital radiography, CT, PET, and MR are complicated imaging modalities which are composed of many hardware and software components. These components work together in a highly coordinated chain of events with the intent to produce high quality images. Acquisition, processing and reconstruction of data must occur in a precise way for optimum image quality to be achieved. Any error or unexpected event in the entire process can produce unwanted pixel intensities in the final images which may contribute to visible image artifacts...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047077/we-g-209-03-pet
#12
B Kemp
Digital radiography, CT, PET, and MR are complicated imaging modalities which are composed of many hardware and software components. These components work together in a highly coordinated chain of events with the intent to produce high quality images. Acquisition, processing and reconstruction of data must occur in a precise way for optimum image quality to be achieved. Any error or unexpected event in the entire process can produce unwanted pixel intensities in the final images which may contribute to visible image artifacts...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046416/we-g-209-04-mri
#13
R Pooley
Digital radiography, CT, PET, and MR are complicated imaging modalities which are composed of many hardware and software components. These components work together in a highly coordinated chain of events with the intent to produce high quality images. Acquisition, processing and reconstruction of data must occur in a precise way for optimum image quality to be achieved. Any error or unexpected event in the entire process can produce unwanted pixel intensities in the final images which may contribute to visible image artifacts...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046296/we-g-209-00-identifying-image-artifacts-their-causes-and-how-to-fix-them
#14
Robert Pooley
Digital radiography, CT, PET, and MR are complicated imaging modalities which are composed of many hardware and software components. These components work together in a highly coordinated chain of events with the intent to produce high quality images. Acquisition, processing and reconstruction of data must occur in a precise way for optimum image quality to be achieved. Any error or unexpected event in the entire process can produce unwanted pixel intensities in the final images which may contribute to visible image artifacts...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28009554/x-ray-grating-interferometer-for-in%C3%A2-situ-and-at-wavelength-wavefront-metrology
#15
Yves Kayser, Christian David, Uwe Flechsig, Juraj Krempasky, Volker Schlott, Rafael Abela
A wavefront metrology setup based on the X-ray grating interferometry technique for spatially resolved, quantitative, in situ and at-wavelength measurements of the wavefront at synchrotron radiation and hard X-ray free-electron laser beamlines is reported. Indeed, the ever-increasing demands on the optical components to preserve the wavefront shape and the coherence of the delivered X-ray beam call for more and more sensitive diagnostic instruments. Thanks to its angular sensitivity, X-ray grating interferometry has been established in recent years as an adequate wavefront-sensing technique for quantitatively assessing the quality of the X-ray wavefront under working conditions and hence for the in situ investigation of X-ray optical elements...
January 1, 2017: Journal of Synchrotron Radiation
https://www.readbyqxmd.com/read/27957401/bamboo-tea-reduction-of-taxonomic-complexity-and-application-of-dna-diagnostics-based-on-rbcl-and-matk-sequence-data
#16
Thomas Horn, Annette Häser
BACKGROUND: Names used in ingredient lists of food products are trivial and in their nature rarely precise. The most recent scientific interpretation of the term bamboo (Bambusoideae, Poaceae) comprises over 1,600 distinct species. In the European Union only few of these exotic species are well known sources for food ingredients (i.e., bamboo sprouts) and are thus not considered novel foods, which would require safety assessments before marketing of corresponding products. In contrast, the use of bamboo leaves and their taxonomic origin is mostly unclear...
2016: PeerJ
https://www.readbyqxmd.com/read/27931298/utility-of-component-diagnostic-testing-in-guiding-oral-food-challenges-to-milk-and-egg
#17
Julie Wang
BACKGROUND: Food allergies affect up to 8% of children, and milk and egg allergies are the most common triggers. Accurately diagnosing these food allergies is important to prevent allergic reactions and to avoid unnecessary dietary restrictions. However, positive skin-prick tests and detectable levels of serum food specific immunoglobulin E (IgE) alone may not be diagnostic for food allergy. Advances in the identification of relevant allergens and the development of recombinant proteins now allow assessment of IgE binding to individual proteins within a food...
November 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/27925506/aliphatic-and-polycyclic-aromatic-hydrocarbons-pahs-in-soils-of-the-northwest-qinling-mountains-patterns-potential-risk-and-an-appraisal-of-the-pah-ratios-to-infer-their-source
#18
Yanhong Liu, Yingqin Wu, Yanqing Xia, Tianzhu Lei, Chuntao Tian, Xiaohuan Hou
Surface soils from the tourist areas of the northwest Qinling Mountains were analyzed to determine the concentrations, probable sources and potential risks of hydrocarbons. Concentrations of aliphatic and aromatic hydrocarbons ranged from 4.18 to 3240 ng g(-1) and 0.0462 to 101 ng g(-1) dry weight, respectively. The extent of soil contamination by hydrocarbons was generally typified by unpolluted to slightly polluted levels. The incremental lifetime cancer risks (ILCRs) for exposure to soil-borne PAHs indicated complete safety for tourists...
March 21, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/27910570/imaging-crystal-spectrometer-for-high-resolution-x-ray-measurements-on-electron-beam-ion-traps-and-tokamaks
#19
P Beiersdorfer, E W Magee, N Hell, G V Brown
We describe a crystal spectrometer implemented on the Livermore electron beam ion traps that employ two spherically bent quartz crystals and a cryogenically cooled back-illuminated charge-coupled device detector to measure x rays with a nominal resolving power of λ/Δλ ≥ 10 000. Its focusing properties allow us to record x rays either with the plane of dispersion perpendicular or parallel to the electron beam and, thus, to preferentially select one of the two linear x-ray polarization components. Moreover, by choice of dispersion plane and focussing conditions, we use the instrument either to image the distribution of the ions within the 2 cm long trap region, or to concentrate x rays of a given energy to a point on the detector, which optimizes the signal-to-noise ratio...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27891156/usefulness-of-component-resolved-analysis-of-cat-allergy-in-routine-clinical-practice
#20
Katharina Eder, Sven Becker, Marion San Nicoló, Alexander Berghaus, Moritz Gröger
BACKGROUND: Cat allergy is of great importance, and its prevalence is increasing worldwide. Cat allergens and house dust mite allergens represent the major indoor allergens; however, they are ubiquitous. Cat sensitization and allergy are known risk factors for rhinitis, bronchial hyperreactivity and asthma. Thus, the diagnosis of sensitization to cats is important for any allergist. METHODS: 70 patients with positive skin prick tests for cats were retrospectively compared regarding their skin prick test results, as well as their specific immunoglobulin E antibody profiles with regard to their responses to the native cat extract, rFel d 1, nFel d 2 and rFel d 4...
2016: Allergy, Asthma, and Clinical Immunology
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