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Component resolved diagnostics

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https://www.readbyqxmd.com/read/29094067/comorbidities-confounding-the-outcomes-of-surgery-for-third-window-syndrome-outlier-analysis
#1
P Ashley Wackym, Heather T Mackay-Promitas, Shaban Demirel, Gerard J Gianoli, Martin S Gizzi, Dale M Carter, David A Siker
Objective: Patients with third window syndrome and superior semicircular canal dehiscence (SSCD) symptoms whose surgical outcomes placed them as outliers were systematically studied to determine comorbidities that were responsible for their poor outcomes due to these confounding factors. Study Design: Observational analytic case-control study in a tertiary referral center. Methods: Twelve adult patients with clinical SSCD syndrome underwent surgical management and had outcomes that did not resolve all of their subjective symptoms...
October 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29060009/ultrasonic-thermal-dust-a-method-to-monitor-deep-tissue-temperature-profiles
#2
B Arda Ozilgen, Michel M Maharbiz
We demonstrate a tetherless, sub-millimeter implantable temperature sensing system employing ultrasonic powering and ultrasonic backscatter modulation assembled using commercially available components. We demonstrate two sizes of sensors based on available components with volumes of 1.45 mm(3) and 0.118 mm(3). Individual sensors are able to resolve ±0.5°C changes in temperature, suitable for medical diagnostic and monitoring purposes. We verify less than 0.3°C drift in temperature readings over 14 days in physiological conditions...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29056697/respiratory-allergens-from-furred-mammals-environmental-and-occupational-exposure
#3
REVIEW
Eva Zahradnik, Monika Raulf
Furry mammals kept as pets, farm and laboratory animals are important allergen sources. The prevalence of sensitization to furred mammals appears to be increasing worldwide. Several mammalian allergens from diverse species are well characterized with regard to their molecular structure and immunogenicity, and some are already available for component-resolved allergy diagnostics. The distribution of various mammalian allergens has been extensively studied during the past few decades. Animal allergens were found to be ubiquitous in the human environment, even in places where no animals reside, with concentrations differing considerably between locations and geographical regions...
August 4, 2017: Veterinary Sciences
https://www.readbyqxmd.com/read/29055045/diagnostic-relevance-of-ige-sensitization-profiles-to-eight-recombinant-phleum-pratense-molecules
#4
Francesca Cipriani, Carla Mastrorilli, Salvatore Tripodi, Giampaolo Ricci, Serena Perna, Valentina Panetta, Riccardo Asero, Arianna Dondi, Annamaria Bianchi, Nunzia Maiello, Michele Miraglia Del Giudice, Tullio Frediani, Francesco Macrì, Sandra Lucarelli, Iride Dello Iacono, Maria Francesca Patria, Elena Varin, Diego Peroni, Loredana Chini, Viviana Moschese, Roberto Bernardini, Giuseppe Pingitore, Umberto Pelosi, Mariangela Tosca, Francesco Paravati, Ifigenia Sfika, Andrea Di Rienzo Businco, Calotta Povesi Dascola, Pasquale Comberiati, Simone Frediani, Caterina Lambiase, Maria Carmen Verga, Diego Faggian, Mario Plebani, Mauro Calvani, Carlo Caffarelli, Paolo Maria Matricardi
BACKGROUND: Grass pollen-related seasonal allergic rhinoconjunctivitis (SARg) is clinically heterogeneous in severity, comorbidities and response to treatment. The component-resolved diagnostics disclosed also a high heterogeneity at molecular level. Our study aimed at analyzing the characteristics of the IgE sensitization to Phleum pratense molecules and investigating the diagnostic relevance of such molecules in childhood. METHODS: We examined 1120 children (age 4-18y) with SARg...
October 20, 2017: Allergy
https://www.readbyqxmd.com/read/29053634/petroleum-hydrocarbon-profiles-of-water-and-sediment-of-algoa-bay-eastern-cape-south-africa
#5
Abiodun O Adeniji, Omobola O Okoh, Anthony I Okoh
Petroleum hydrocarbon profiles of water and sediment samples of Algoa Bay in the Eastern Cape Province of South Africa were assessed using standard analytical procedures. Water (from surface and bottom levels) and sediment samples were collected from five locations in the bay from February to June 2016. Extraction of the petroleum hydrocarbons from the water and sediment samples collected was achieved using liquid-liquid and Soxhlet extraction techniques, respectively, followed by column clean up. Target compounds were analytically determined with gas chromatography-flame ionization detector (GC-FID) and quantified by integrating the areas of both the resolved and unresolved components...
October 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29047927/fiber-coupled-uv-swir-hyperspectral-imaging-sensor-for-combustion-diagnostics
#6
Paul S Hsu, Daniel Lauriola, Naibo Jiang, Joseph D Miller, James R Gord, Sukesh Roy
A fiber-coupled, hyperspectral imaging sensor (HSIS) ranging from ultraviolet (UV) to short-wavelength-infrared (SWIR) wavelengths is developed for remote detection of planar [two-dimensional (2D)], spectrally resolved flame emission. The key component of the sensor is a dimension-reduction 2D-to-1D (one-dimensional) fiber-optic array that contains 1024 fibers and features high-UV optical transmission (>30% transmission at 310-340 nm, >90% at 340-2000 nm), wide operational wavelengths (300-2400 nm), and a compact and robust design (full length <5  cm)...
July 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28943412/magnetic-resonance-microdynamic-imaging-reveals-distinct-tissue-microenvironments
#7
Dan Benjamini, Peter J Basser
Magnetic resonance imaging (MRI) provides a powerful set of tools with which to investigate biological tissues noninvasively and in vivo. Tissues are heterogeneous in nature; an imaging voxel contains an ensemble of different cells and extracellular matrix components. A long-standing challenge has been to infer the content of and interactions among these microscopic tissue components within a macroscopic imaging voxel. Spatially resolved multidimensional relaxation-diffusion correlation (REDCO) spectroscopy holds the potential to deliver such microdynamic information...
September 22, 2017: NeuroImage
https://www.readbyqxmd.com/read/28940152/osteomyelitis-risk-in-patients-with-transfemoral-amputations-treated-with-osseointegration-prostheses
#8
Jonatan Tillander, Kerstin Hagberg, Örjan Berlin, Lars Hagberg, Rickard Brånemark
BACKGROUND: Percutaneous anchoring of femoral amputation prostheses using osseointegrating titanium implants has been in use for more than 25 years. The method offers considerable advantages in daily life compared with conventional socket prostheses, however long-term success might be jeopardized by implant-associated infection, especially osteomyelitis, but the long-term risk of this complication is unknown. QUESTIONS/PURPOSES: (1) To quantify the risk of osteomyelitis, (2) to characterize the clinical effect of osteomyelitis (including risk of implant extraction and impairments to function), and (3) to determine whether common patient factors (age, sex, body weight, diabetes, and implant component replacements) are associated with osteomyelitis in patients with transfemoral amputations treated with osseointegrated titanium implants...
December 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28890861/idiopathic-anaphylaxis
#9
REVIEW
Bright I Nwaru, Sangeeta Dhami, Aziz Sheikh
Idiopathic anaphylaxis is a rare life-threatening disorder with symptoms similar to other forms of anaphylaxis. There is lack of a robust evidence base underpinning the treatment of anaphylaxis and even less so for idiopathic anaphylaxis. Much of the evidence therefore comes from relatively small case series and expert opinion. Idiopathic anaphylaxis is a diagnosis of exclusion, requiring a thorough history and careful diagnostic work-up investigating possible triggers and underlying predisposing factors. Key diagnostic tests include skin-prick testing, tests for specific-IgE, component-resolved diagnostics, and in some cases for allergen challenge tests...
2017: Current Treatment Options in Allergy
https://www.readbyqxmd.com/read/28890490/time-and-space-resolved-optical-diagnostics-for-discharge-plasmas-separately-formed-in-aqueous-solution
#10
Motohiro Banno, Hotaka Takakuwa, Hiroharu Yui
When high voltage is applied to a gap between electrodes in aqueous solution, a discharge plasma is generated that connects the edges of the facing electrodes. When the width of the gap between the electrodes is extended to more than several millimeters, the plasma is separated into two and they are localized at the vicinities of the edges of the anode (+plasma) and cathode (-plasma). Although they are expected to supply characteristic reaction fields, the properties of the plasmas, such as electron number density and temperatures of transient species, have not yet been clarified...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28791829/intravitreal-ocriplasmin-a-breakthrough-in-the-treatment-of-vitreomacular-traction
#11
REVIEW
Anna E Mec-Słomska, Joanna Adamiec-Mroczek, Ewa Kuźmicz, Marta Misiuk-Hojło
Vitreoretinal interface pathologies, such as vitreomacular traction syndrome, epiretinal membranes and macular holes are sight-threatening conditions and one of the important causes of vision defects and vision loss. To this date, vigilance with observation of how the vitreomacular traction resolves, or vitreoretinal surgery in more severe cases, were the only treatment options. Recent rapid progress in ophthalmology, especially in diagnostic and visualization techniques, provided better insight into the mechanisms taking place on the vitreoretinal surface, which enabled a more accurate selection of treatment options...
May 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28759475/component-resolved-diagnostics-for-hymenoptera-venom-allergy
#12
Thilo Jakob, Ulrich Müller, Arthur Helbling, Edzard Spillner
PURPOSE OF REVIEW: Component-resolved diagnostics makes use of defined allergen molecules to analyse IgE-mediated sensitizations at a molecular level. Here, we review recent studies on the use of component-resolved diagnostics in the field of Hymenoptera venom allergy (HVA) and discuss its benefits and limitations. RECENT FINDINGS: Component resolution in HVA has moved from single molecules to panels of allergens. Detection of specific immunoglobulin E (sIgE) to marker and cross-reactive venom allergens has been reported to facilitate the discrimination between primary sensitization and cross-reactivity and thus, to provide a better rationale for prescribing venom immunotherapy (VIT), particularly in patients sensitized to both honeybee and vespid venom...
October 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28757143/methods-in-allergy-immunology-food-challenges
#13
EDITORIAL
Barbara K Ballmer-Weber, Kirsten Beyer
Since there is no in vitro test, which can accurately predict the clinical relevance of a sensitization to food, the oral food challenge still remains the most reliable procedure to confirm or exclude food allergy and to assess the development of tolerance in children with potentially transient food allergies such as to cow's milk, hen's egg, wheat or soy. Although in the last few years component-resolved diagnostic has improved the food allergy diagnostics, especially in peanut and tree nut allergy, the majority of patients still need to undergo oral food challenge...
July 27, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28663879/fluorescence-lifetime-microscopy-of-nadh-distinguishes-alterations-in-cerebral-metabolism-in-vivo
#14
Mohammad A Yaseen, Jason Sutin, Weicheng Wu, Buyin Fu, Hana Uhlirova, Anna Devor, David A Boas, Sava Sakadžić
Evaluating cerebral energy metabolism at microscopic resolution is important for comprehensively understanding healthy brain function and its pathological alterations. Here, we resolve specific alterations in cerebral metabolism in vivo in Sprague Dawley rats utilizing minimally-invasive 2-photon fluorescence lifetime imaging (2P-FLIM) measurements of reduced nicotinamide adenine dinucleotide (NADH) fluorescence. Time-resolved fluorescence lifetime measurements enable distinction of different components contributing to NADH autofluorescence...
May 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28623421/comparison-of-dual-energy-ct-ultrasound-and-surface-measurement-for-assessing-tophus-dissolution-during-rapid-urate-debulking
#15
Dodji V Modjinou, Svetlana Krasnokutsky, Soterios Gyftopoulos, Virginia C Pike, Elaine Karis, Robert T Keenan, Kristen Lee, Daria B Crittenden, Jonathan Samuels, Michael H Pillinger
Tophaceous gout is painful and impairs quality of life. The optimal modality for assessing tophus resolution in response to urate-lowering treatment remains poorly defined. Using pegloticase as a model system for resolving tophi, we compared multiple imaging and physical diagnostic strategies for assessing tophus resolution. A 32-year-old subject with chronic refractory tophaceous gout was enrolled and received 6 months of pegloticase treatment. Measurements of tophi using vernier calipers (monthly), photographs and musculoskeletal ultrasound (MSK-US; every 3 months), and dual-energy CT (DECT) were compared...
June 16, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28616774/-molecular-component-resolved-allergy-diagnostics-in-ent
#16
REVIEW
L Klimek, S Becker
Molecular component-resolved diagnostics (CRD) are, in addition to its research applications, being increasingly used in daily allergological routine. CRD offers improved diagnostic accuracy via a better understanding of the underlying allergen causing symptoms and helps to distinguish between true sensitization and cross reactions in polysensitized patients, thereby providing an approach for individual personalized therapy. Particularly in food allergies and anaphylaxis, CRD can stratify risks for the recurrence of reactions and their severity...
June 14, 2017: HNO
https://www.readbyqxmd.com/read/28605372/a-component-resolved-diagnostic-approach-for-a-study-on-grass-pollen-allergens-in-chinese-southerners-with-allergic-rhinitis-and-or-asthma
#17
Wenting Luo, Guichang Pan, Huimin Huang, Peiyan Zheng, Nili Wei, Yifei Zhang, Guangqiao Zeng, Baoqing Sun
Sensitization to grass pollen imposes a global risk for allergic airway diseases. Although prevention relies on local investigation of the pollen allergens, data on this topic are limited in southern China. Any available data were obtained by self-report questionnaires, skin prick tests, and total or specific IgE tests using crude extracts. For many reasons, these methods are unreliable. Serum sIgE reactivity to Bermuda grass, Timothy grass, and Humulus scandens allergens in a cohort of patients from Greater Guangzhou (southern China's largest city and its outskirts) with allergic rhinitis and/or asthma were examined using a fully-automated immunoassay analyzer as a component-resolved diagnostics (CRD) tool...
June 4, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28604163/allergen-specific-immunotherapy-of-hymenoptera-venom-allergy-also-a-matter-of-diagnosis
#18
Maximilian Schiener, Anke Graessel, Markus Ollert, Carsten B Schmidt-Weber, Simon Blank
Stings of hymenoptera can induce IgE-mediated hypersensitivity reactions in venom-allergic patients, ranging from local up to severe systemic reactions and even fatal anaphylaxis. Allergic patients' quality of life can be mainly improved by altering their immune response to tolerate the venoms by injecting increasing venom doses over years. This venom-specific immunotherapy is highly effective and well tolerated. However, component-resolved information about the venoms has increased in the last years. This knowledge is not only able to improve diagnostics as basis for an accurate therapy, but was additionally used to create tools which enable the analysis of therapeutic venom extracts on a molecular level...
October 3, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28501976/component-resolved-diagnosis-in-hymenoptera-anaphylaxis
#19
REVIEW
D Tomsitz, K Brockow
PURPOSE OF REVIEW: Hymenoptera anaphylaxis is one of the leading causes of severe allergic reactions and can be fatal. Venom-specific immunotherapy (VIT) can prevent a life-threatening reaction; however, confirmation of an allergy to a Hymenoptera venom is a prerequisite before starting such a treatment. Component resolved diagnostics (CRD) have helped to better identify the responsible allergen. RECENT FINDINGS: Many new insect venom allergens have been identified within the last few years...
June 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28490893/sesame-allergy-current-perspectives
#20
REVIEW
Adil Adatia, Ann Elaine Clarke, Yarden Yanishevsky, Moshe Ben-Shoshan
Sesame is an important global allergen affecting ~0.1% of the North American population. It is a major cause of anaphylaxis in the Middle East and is the third most common food allergen in Israel. We conducted a systematic review of original articles published in the last 10 years regarding the diagnosis and management of sesame allergy. Skin prick testing appears to be a useful predictor of sesame allergy in infants, although data are less consistent in older children and adults. The diagnostic capacity of serum-specific immunoglobulin E is poor, especially in studies that used oral food challenges to confirm the diagnosis...
2017: Journal of Asthma and Allergy
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