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Component resolved diagnostics

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https://www.readbyqxmd.com/read/28101431/non-invasive-terahertz-imaging-of-tissue-water-content-for-flap-viability-assessment
#1
Neha Bajwa, Joshua Au, Reza Jarrahy, Shijun Sung, Michael C Fishbein, David Riopelle, Daniel B Ennis, Tara Aghaloo, Maie A St John, Warren S Grundfest, Zachary D Taylor
Accurate and early prediction of tissue viability is the most significant determinant of tissue flap survival in reconstructive surgery. Perturbation in tissue water content (TWC) is a generic component of the tissue response to such surgeries, and, therefore, may be an important diagnostic target for assessing the extent of flap viability in vivo. We have previously shown that reflective terahertz (THz) imaging, a non-ionizing technique, can generate spatially resolved maps of TWC in superficial soft tissues, such as cornea and wounds, on the order of minutes...
January 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28092637/non-invasive-classification-of-breast-microcalcifications-using-x-ray-coherent-scatter-computed-tomography
#2
Bahaa Ghammraoui, Lucretiu M Popescu
We investigate the use of energy dispersive x-ray coherent scatter computed tomography (ED-CSCT) as a non-invasive diagnostic method to differentiate between type I and type II breast calcifications. This approach is sensitive to the differences of composition and internal crystal structure of different types of microcalcifications. The study is carried out by simulating a CSCT system with a scanning pencil beam, considering a polychromatic x-ray source and an energy-resolving photon counting detector. In a first step, the multidimensional angle and energy distributed CSCT data is reduced to the projection-space distributions of only a few components, corresponding to the expected target composition: adipose, glandular tissue, weddellite (calcium oxalate) for type I calcifications, and hydroxyapatite for type II calcifications...
February 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28060371/basaloid-blue-salivary-gland-tumors
#3
Raja R Seethala
Basaloid tumors are a common diagnostic problem in salivary gland pathology. However, delineating each of these tumor types is facilitated by an algorithmic approach incorporated by tumor border and cell types. This approach greatly diminishes the challenge of separating polymorphous low-grade adenocarcinoma (PLGA) from adenoid cystic carcinoma (ACC). Despite the overlap in growth pattern, ACC is biphasic while PLGA is not. More relevant challenges, namely differentiation of the biphasic basaloid neoplasms including: epithelial-myoepithelial carcinoma (EMCA), cellular pleomorphic adenoma (PA), basal cell adenoma (BCA), and basal cell adenocarcinoma (BCAC), are resolved by a combination of morphologic, immunophenotypic, and to a limited extent, molecular features...
January 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28048371/we-g-209-01-digital-radiography
#4
B Schueler
: Digital radiography, CT, PET, and MR are complicated imaging modalities which are composed of many hardware and software components. These components work together in a highly coordinated chain of events with the intent to produce high quality images. Acquisition, processing and reconstruction of data must occur in a precise way for optimum image quality to be achieved. Any error or unexpected event in the entire process can produce unwanted pixel intensities in the final images which may contribute to visible image artifacts...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047725/we-g-209-02-ct
#5
J Kofler
: Digital radiography, CT, PET, and MR are complicated imaging modalities which are composed of many hardware and software components. These components work together in a highly coordinated chain of events with the intent to produce high quality images. Acquisition, processing and reconstruction of data must occur in a precise way for optimum image quality to be achieved. Any error or unexpected event in the entire process can produce unwanted pixel intensities in the final images which may contribute to visible image artifacts...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047077/we-g-209-03-pet
#6
B Kemp
: Digital radiography, CT, PET, and MR are complicated imaging modalities which are composed of many hardware and software components. These components work together in a highly coordinated chain of events with the intent to produce high quality images. Acquisition, processing and reconstruction of data must occur in a precise way for optimum image quality to be achieved. Any error or unexpected event in the entire process can produce unwanted pixel intensities in the final images which may contribute to visible image artifacts...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046416/we-g-209-04-mri
#7
R Pooley
: Digital radiography, CT, PET, and MR are complicated imaging modalities which are composed of many hardware and software components. These components work together in a highly coordinated chain of events with the intent to produce high quality images. Acquisition, processing and reconstruction of data must occur in a precise way for optimum image quality to be achieved. Any error or unexpected event in the entire process can produce unwanted pixel intensities in the final images which may contribute to visible image artifacts...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046296/we-g-209-00-identifying-image-artifacts-their-causes-and-how-to-fix-them
#8
Robert Pooley
: Digital radiography, CT, PET, and MR are complicated imaging modalities which are composed of many hardware and software components. These components work together in a highly coordinated chain of events with the intent to produce high quality images. Acquisition, processing and reconstruction of data must occur in a precise way for optimum image quality to be achieved. Any error or unexpected event in the entire process can produce unwanted pixel intensities in the final images which may contribute to visible image artifacts...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28009554/x-ray-grating-interferometer-for-in%C3%A2-situ-and-at-wavelength-wavefront-metrology
#9
Yves Kayser, Christian David, Uwe Flechsig, Juraj Krempasky, Volker Schlott, Rafael Abela
A wavefront metrology setup based on the X-ray grating interferometry technique for spatially resolved, quantitative, in situ and at-wavelength measurements of the wavefront at synchrotron radiation and hard X-ray free-electron laser beamlines is reported. Indeed, the ever-increasing demands on the optical components to preserve the wavefront shape and the coherence of the delivered X-ray beam call for more and more sensitive diagnostic instruments. Thanks to its angular sensitivity, X-ray grating interferometry has been established in recent years as an adequate wavefront-sensing technique for quantitatively assessing the quality of the X-ray wavefront under working conditions and hence for the in situ investigation of X-ray optical elements...
January 1, 2017: Journal of Synchrotron Radiation
https://www.readbyqxmd.com/read/27957401/bamboo-tea-reduction-of-taxonomic-complexity-and-application-of-dna-diagnostics-based-on-rbcl-and-matk-sequence-data
#10
Thomas Horn, Annette Häser
BACKGROUND: Names used in ingredient lists of food products are trivial and in their nature rarely precise. The most recent scientific interpretation of the term bamboo (Bambusoideae, Poaceae) comprises over 1,600 distinct species. In the European Union only few of these exotic species are well known sources for food ingredients (i.e., bamboo sprouts) and are thus not considered novel foods, which would require safety assessments before marketing of corresponding products. In contrast, the use of bamboo leaves and their taxonomic origin is mostly unclear...
2016: PeerJ
https://www.readbyqxmd.com/read/27931298/utility-of-component-diagnostic-testing-in-guiding-oral-food-challenges-to-milk-and-egg
#11
Julie Wang
BACKGROUND: Food allergies affect up to 8% of children, and milk and egg allergies are the most common triggers. Accurately diagnosing these food allergies is important to prevent allergic reactions and to avoid unnecessary dietary restrictions. However, positive skin-prick tests and detectable levels of serum food specific immunoglobulin E (IgE) alone may not be diagnostic for food allergy. Advances in the identification of relevant allergens and the development of recombinant proteins now allow assessment of IgE binding to individual proteins within a food...
November 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/27925506/aliphatic-and-polycyclic-aromatic-hydrocarbons-pahs-in-soils-of-the-northwest-qinling-mountains-patterns-potential-risk-and-an-appraisal-of-the-pah-ratios-to-infer-their-source
#12
Yanhong Liu, Yingqin Wu, Yanqing Xia, Tianzhu Lei, Chuntao Tian, Xiaohuan Hou
Surface soils from the tourist areas of the northwest Qinling Mountains were analyzed to determine the concentrations, probable sources and potential risks of hydrocarbons. Concentrations of aliphatic and aromatic hydrocarbons ranged from 4.18 to 3240 ng g(-1) and 0.0462 to 101 ng g(-1) dry weight, respectively. The extent of soil contamination by hydrocarbons was generally typified by unpolluted to slightly polluted levels. The incremental lifetime cancer risks (ILCRs) for exposure to soil-borne PAHs indicated complete safety for tourists...
December 7, 2016: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/27910570/imaging-crystal-spectrometer-for-high-resolution-x-ray-measurements-on-electron-beam-ion-traps-and-tokamaks
#13
P Beiersdorfer, E W Magee, N Hell, G V Brown
We describe a crystal spectrometer implemented on the Livermore electron beam ion traps that employ two spherically bent quartz crystals and a cryogenically cooled back-illuminated charge-coupled device detector to measure x rays with a nominal resolving power of λ/Δλ ≥ 10 000. Its focusing properties allow us to record x rays either with the plane of dispersion perpendicular or parallel to the electron beam and, thus, to preferentially select one of the two linear x-ray polarization components. Moreover, by choice of dispersion plane and focussing conditions, we use the instrument either to image the distribution of the ions within the 2 cm long trap region, or to concentrate x rays of a given energy to a point on the detector, which optimizes the signal-to-noise ratio...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27891156/usefulness-of-component-resolved-analysis-of-cat-allergy-in-routine-clinical-practice
#14
Katharina Eder, Sven Becker, Marion San Nicoló, Alexander Berghaus, Moritz Gröger
BACKGROUND: Cat allergy is of great importance, and its prevalence is increasing worldwide. Cat allergens and house dust mite allergens represent the major indoor allergens; however, they are ubiquitous. Cat sensitization and allergy are known risk factors for rhinitis, bronchial hyperreactivity and asthma. Thus, the diagnosis of sensitization to cats is important for any allergist. METHODS: 70 patients with positive skin prick tests for cats were retrospectively compared regarding their skin prick test results, as well as their specific immunoglobulin E antibody profiles with regard to their responses to the native cat extract, rFel d 1, nFel d 2 and rFel d 4...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27736060/photophysical-properties-of-organoplatinum-ii-compounds-and-derived-self-assembled-metallacycles-and-metallacages-fluorescence-and-its-applications
#15
Manik Lal Saha, Xuzhou Yan, Peter J Stang
Over the past couple of decades, coordination-driven self-assembly has evolved as a broad multidisciplinary domain that not only covers the syntheses of aesthetically pleasing supramolecular architectures but also emerges as a method to form new optical materials, chemical sensors, theranostic agents, and compounds with light-harvesting and emissive properties. The majority of these applications depend upon investigations that reveal the photophysical nature and electronic structure of supramolecular coordination complexes (SCCs), including two-dimensional (2D) metallacycles and three-dimensional (3D) metallacages...
November 15, 2016: Accounts of Chemical Research
https://www.readbyqxmd.com/read/27726410/ct-screening-for-lung-cancer-part-solid-nodules-in-baseline-and-annual-repeat-rounds
#16
Claudia I Henschke, Rowena Yip, James P Smith, Andrea S Wolf, Raja M Flores, Mingzhu Liang, Mary M Salvatore, Ying Liu, Dong Ming Xu, David F Yankelevitz
OBJECTIVE: The purpose of this study was to assess the frequencies of identifying participants with part-solid nodules, of diagnostic pursuit, of diagnoses of lung cancer, and long-term lung cancer survival in baseline and annual repeat rounds of CT screening in the International Early Lung Cancer Action Project. MATERIALS AND METHODS: Screenings were performed under a common protocol. Participants with solid, nonsolid, and part-solid nodules and the diagnoses of lung cancer were documented...
December 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27644013/ana-o-3-specific-ige-is-a-good-predictor-for-clinically-relevant-cashew-allergy-in-children
#17
L Lange, L Lasota, A Finger, D Vlajnic, S Büsing, J Meister, I Brockaert, C Pfannenstiel, F Friedrichs, M Price, V Trendelenburg, B Niggemann, K Beyer
INTRODUCTION: Component resolved diagnostics using specific IgE to 2 S albumins has shown to be a valuable new option in diagnostic procedure. Ana o 3 is a 2 S albumin from cashew. Aim of this study was to investigate the role of Ana o 3 specific serum IgE in the diagnosis of cashew allergy and to identify cut-off levels to replace oral food challenges. Moreover, the value of additional determination of total IgE has been investigated. METHODS: In a multicentre study we analysed specific IgE to cashew extract and Ana o 3 as well as total IgE in children with suspected cashew allergy using the ImunoCAP-FEIA and a standardized diagnostic procedure including oral challenges where indicated...
September 19, 2016: Allergy
https://www.readbyqxmd.com/read/27543004/recent-advances-in-component-resolved-diagnosis-in-food-allergy
#18
REVIEW
Magnus P Borres, Nobuyuki Maruyama, Sakura Sato, Motohiro Ebisawa
Due to the high prevalence of food allergic diseases globally there are increasing demands in clinical practice for managing IgE-mediated conditions. During the last decade, component resolved diagnostics has been introduced into the field of clinical allergology, providing information that cannot be obtained from extract-based tests. Component resolved data facilitate more precise diagnosis of allergic diseases and identify sensitizations attributable to cross-reactivity. Furthermore it assists risk assessment in clinical practice as sensitization to some allergenic molecules is related to persistence of clinical symptoms and systemic rather than local reactions...
October 2016: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/27526429/-diagnosis-of-food-allergy
#19
REVIEW
Małgorzata Leśniak, Maciej Juda, Łukasz Dyczek, Maria Czarnobilska, Magdalena Leśniak, Ewa Czarnobilska
Food allergy is most often linked to the type I allergic reaction, while IgE-dependent mechanism causes symptoms in only about 50% of patients. If symptoms are coming from other types of allergic reactions we do not have enough standardized diagnostic methods. The purpose of our review is to discuss the possibilities of diagnosis of food allergies. Regardless of the causal mechanism the interview has the most important role in the diagnosis, and the gold standard is a double blind placebo controlled food challenge...
2016: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/27519815/fundus-autofluorescence-lifetimes-are-increased-in-non-proliferative-diabetic-retinopathy
#20
Johanna Schmidt, Sven Peters, Lydia Sauer, Dietrich Schweitzer, Matthias Klemm, Regine Augsten, Nicolle Müller, Martin Hammer
PURPOSE: To discriminate non-proliferative diabetic retinopathy (NPDR) patients from healthy controls by fluorescence lifetime imaging ophthalmoscopy (FLIO). METHODS: A prototype FLIO (Heidelberg-Engineering, Heidelberg, Germany) was used to examine the retina of 33 patients and 28 controls. As increased fluorescence of the diabetic lens is known, the lenses of 34 patients and 24 controls were investigated as well. Time-resolved decay was detected in two spectral channels (ch1: 498-560 nm, ch2: 560-720 nm) and approximated by a series of three exponential functions yielding in lifetimes (τ1 , τ2 , τ3 ), amplitudes (α1 , α2 , α3 ) and their amplitude-weighted means (τm )...
February 2017: Acta Ophthalmologica
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