keyword
https://read.qxmd.com/read/38529801/precision-allergy-molecular-diagnosis-applications-in-food-allergy
#1
JOURNAL ARTICLE
Sakura Sato, Motohiro Ebisawa
PURPOSE OF THE REVIEW: Precision medicine has become important in the diagnosis and management of food allergies. This review summarizes the latest information regarding molecular allergology, an essential component of food allergy managements. RECENT FINDINGS: Component-resolved diagnostics (CRD) can be used to investigate sensitization to allergens based on symptoms and to reveal co-sensitization and/or cross-sensitization in patients with allergies. The following allergen components are known to be associated with symptoms: ovomucoid from eggs, omega-5 gliadin from wheat, and many storage proteins (Gly m 8 from soy, Ara h 2 from peanut, Cor a 14 from hazelnut, Ana o 3 from cashew nut, Jug r 1 from walnut, and Ses i 1 from sesame)...
March 27, 2024: Current Opinion in Allergy and Clinical Immunology
https://read.qxmd.com/read/38513837/ige-to-cyclophilins-in-pollen-allergic-children-epidemiological-clinical-and-diagnostic-relevance-of-a-neglected-panallergen
#2
JOURNAL ARTICLE
Paolo Maria Matricardi, Ekaterina Potapova, Valentina Panetta, Jonas Lidholm, Lars Mattsson, Enrico Scala, Roberto Bernardini, Carlo Caffarelli, Antonella Casani, Rosa Cervone, Loredana Chini, Pasquale Comberiati, Giovanna De Castro, Michele Miraglia Del Giudice, Iride Dello Iacono, Andrea Di Rienzo Businco, Marcella Gallucci, Arianna Giannetti, Viviana Moschese, Elena Varin, Annamaria Bianchi, Mauro Calvani, Tullio Frediani, Francesco Macrì, Nunzia Maiello, Francesco Paravati, Umberto Pelosi, Diego Peroni, Giuseppe Pingitore, Mariangela Tosca, Anna Maria Zicari, Giampaolo Ricci, Riccardo Asero, Salvatore Tripodi
BACKGROUND: - Cyclophilins are ubiquitous panallergens whose epidemiological, diagnostic, and clinical relevance is largely unknown and whose sensitization is rarely examined in routine allergy practice. The aim of this study was to investigate the epidemiological, diagnostic, and clinical relevance of cyclophilin in seasonal allergic rhinitis and its comorbidities. METHODS: - We examined a random sample (25%, n 253) of 1263 Italian children affected by seasonal allergic rhinitis from the "Panallergen in Pediatrics" (PAN-PED) cohort...
March 19, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38499269/intra-bin-correction-and-inter-bin-compensation-of-respiratory-motion-in-free-running-5d-whole-heart-mri
#3
JOURNAL ARTICLE
Christopher W Roy, Bastien Milani, Jérôme Yerly, Salim Si-Mohamed, Ludovica Romanin, Aurélien Bustin, Estelle Tenisch, Tobias Rutz, Milan Prsa, Matthias Stuber
BACKGROUND: Free-running cardiac and respiratory motion-resolved whole-heart 5D MRI can reduce scan planning and provide a means of evaluating respiratory-driven changes in clinical parameters of interest. However, respiratory-resolved imaging can be limited by user-defined parameters which create trade-offs between residual artifact and motion blur. In this work, we develop and validate strategies for both correction of intra-bin and compensation of inter-bin respiratory motion to improve the quality of 5D MRI...
March 16, 2024: Journal of Cardiovascular Magnetic Resonance
https://read.qxmd.com/read/38495690/next-generation-endoscopic-probe-for-detection-of-esophageal-dysplasia-using-combined-oct-and-angle-resolved-low-coherence-interferometry
#4
JOURNAL ARTICLE
Evan T Jelly, Zachary A Steelman, Haoran Zhang, Kengyeh K Chu, Cary C Cotton, Swathi Eluri, Nicholas J Shaheen, Adam Wax
Angle-resolved low-coherence interferometry (a/LCI) is an optical technique that enables depth-specific measurements of nuclear morphology, with applications to detecting epithelial cancers in various organs. Previous a/LCI setups have been limited by costly fiber-optic components and large footprints. Here, we present a novel a/LCI instrument incorporating a channel for optical coherence tomography (OCT) to provide real-time image guidance. We showcase the system's capabilities by acquiring imaging data from in vivo Barrett's esophagus patients...
March 1, 2024: Biomedical Optics Express
https://read.qxmd.com/read/38475973/component-specific-clusters-for-diagnosis-and-prediction-of-allergic-airway-diseases
#5
JOURNAL ARTICLE
Rebecca Howard, Sara Fontanella, Angela Simpson, Clare S Murray, Adnan Custovic, Magnus Rattray
BACKGROUND: Previous studies which applied machine learning on multiplex component-resolved diagnostics arrays identified clusters of allergen components which are biologically plausible and reflect the sources of allergenic proteins and their structural homogeneity. Sensitization to different clusters is associated with different clinical outcomes. OBJECTIVE: To investigate whether within different allergen component sensitization clusters, the internal within-cluster sensitization structure, including the number of c-sIgE responses and their distinct patterns, alters the risk of clinical expression of symptoms...
March 12, 2024: Clinical and Experimental Allergy
https://read.qxmd.com/read/38472043/feasibility-safety-and-diagnostic-yield-of-interventional-cardiac-magnetic-resonance-for-routine-right-heart-catheterization-in-adults
#6
JOURNAL ARTICLE
Francesca Sanguineti, Philippe Garot, Solenn Toupin, Théo Pezel, Yohann Bohbot, Chloé Tawa, Mathieu Poupineauc, Victor Boileve, Valentin Landon, Suzanne Duhamel, Jérôme Garot
BACKGROUND: Real-time cardiac magnetic resonance generates spatially and temporally resolved images of cardiac anatomy and function, without the need for contrast agent or X-ray exposure. Cardiac magnetic resonance-guided right heart catheterization (CMR-RHC) combines the benefits of cardiac magnetic resonance and invasive cardiac catheterization. The clinical adoption of CMR-RHC represents the first step towards the development of cardiac magnetic resonance-guided therapeutic procedures...
February 27, 2024: Archives of Cardiovascular Diseases
https://read.qxmd.com/read/38424720/immunoassay-testing-of-alpha-gal-specific-immunoglobulin-e-data-from-a-national-reference-laboratory
#7
JOURNAL ARTICLE
Abdulrahman Saadalla, Jessica Jacela, Rick Poll, Patricia Slev
BACKGROUND: Immunoassay measurements of serum alpha-gal (AG) specific IgE (sIgE) enable antibody detection and quantification with high sensitivity and specificity and are essential for AG syndrome diagnosis and patient management. We here present and analyze results from over 15 000 patient serum samples tested using the ImmunoCAP (Thermo/Phadia) assay. METHODS: AG-sIgE levels and positivity rates were correlated to patient age, gender, geographic location, repeat testing results, sIgE levels to co-tested red meat whole allergen extracts, and Rocky Mountain spotted fever (RMSF) serology performed on a subset of patient samples...
March 1, 2024: Journal of Applied Laboratory Medicine
https://read.qxmd.com/read/38387961/-component-resolved-diagnosis-of-tree-pollen-allergen-identify-key-allergens-to-develop-treatment-plans
#8
JOURNAL ARTICLE
W T Luo, X H Zheng, J L Zhang, B Q Sun
With the increasing global prevalence of tree pollen allergies, there has been a significant impact on the quality of life for populations. In North and Central China, birch pollen, cypress pollen, and plane tree pollen are the most common allergens for springtime pollen allergy sufferers. The distribution of plants and patterns of pollen transmission in different geographical areas result in varying pollen exposure outcomes, further complicating the challenges in diagnosis and individualized treatment. This article delves into the research progress and clinical application of tree pollen allergies based on the "Molecular Allergology User's Guide 2...
February 6, 2024: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://read.qxmd.com/read/38376470/molecular-profiling-in-bee-venom-allergy-clinical-and-therapeutic-characterization-in-a-portuguese-cohort
#9
JOURNAL ARTICLE
J Cardoso Lopes, P Botelho Alves, H Pires Pereira, F Cunha, I Farinha, A Maresch, R Cunha, G Loureiro, A Todo-Bom, B Tavares
Background. Bee venom allergy (BVA) can trigger local and systemic allergic reactions, including anaphylaxis. Recently, the molecular sensitization profile has gained importance in the reaction's stratification and venom immunotherapy (VIT). Methods. Retrospective analysis of patients with hypersensitivity to BVA, confirmed by specific sIgE to Apis mellifera ≥0.35 kU/L and/or positive skin tests to bee venom commercial extract, evaluated in specialized consultation. Demographic, clinical, and laboratory data (including molecular Api m 1, 4, and 10) were analyzed, looking for risk factors associated with the severity of the index reaction and reactions during VIT...
February 20, 2024: European Annals of Allergy and Clinical Immunology
https://read.qxmd.com/read/38360181/accurate-determination-of-house-dust-mite-sensitization-in-asthma-and-allergic-rhinitis-through-cytometric-detection-of-der-p-1-and-der-p-2-binding-on-basophils-cytobas
#10
JOURNAL ARTICLE
Lin Hsin, Nirupama Varese, Pei Mun Aui, Bruce D Wines, Anouk von Borstel, Laurent Mascarell, P Mark Hogarth, Mark Hew, Robyn E O'Hehir, Menno C van Zelm
BACKGROUND: House dust mite (HDM) is the most common allergen trigger globally for allergic rhinitis and atopic asthma. To expedite accurate confirmation of allergen sensitization, we designed fluorescent allergen tetramers to directly stain specific IgE on basophils to detect specific allergen sensitization using the flow cytometric CytoBas assay. METHODS: Recombinant proteins of major HDM allergens (component), Der f 1, Der p 1 and Der p 2 were biotinylated and conjugated with fluorochrome streptavidins as tetramers...
February 13, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38359101/understanding-the-heterogeneity-of-childhood-allergic-sensitization-and-its-relationship-with-asthma
#11
JOURNAL ARTICLE
Adnan Custovic, Darije Custovic, Sara Fontanella
PURPOSE OF REVIEW: To review the current state of knowledge on the relationship between allergic sensitization and asthma; to lay out a roadmap for the development of IgE biomarkers that differentiate, in individual sensitized patients, whether their sensitization is important for current or future asthma symptoms, or has little or no relevance to the disease. RECENT FINDINGS: The evidence on the relationship between sensitization and asthma suggests that some subtypes of allergic sensitization are not associated with asthma symptoms, whilst others are pathologic...
February 8, 2024: Current Opinion in Allergy and Clinical Immunology
https://read.qxmd.com/read/38336314/identification-of-rblo-t-41-with-a-chitin-binding-type-2-domain-a-novel-major-allergen-from-blomia-tropicalis
#12
JOURNAL ARTICLE
Wenting Luo, Jiale Zhang, Xianhui Zheng, Aoli Li, Miaoyuan Xv, Dongmei Zhou, Cunyin Yuan, YuBao Cui, Baoqing Sun
BACKGROUND: Blomia tropicalis (B. tropicalis) has been reported to impose an increased risk of allergic diseases. However, few characteristics of the unknown allergen components responsible for B. tropicalis allergy and clinical relevance have been fully identified. METHODS: We synthesized and characterized the physicochemical properties and cross-reactivity of the newly discovered recombinant B. tropicalis group 41 allergen (rBlo t 41). Subsequently, sera were collected from 107 B...
February 7, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38335854/cytokine-expression-patterns-a-single-cell-rna-sequencing-and-machine-learning-based-roadmap-for-cancer-classification
#13
JOURNAL ARTICLE
Zhixiang Ren, Yiming Ren, Pengfei Liu, Huan Xu
Cytokines are small protein molecules that exhibit potent immunoregulatory properties, which are known as the essential components of the tumor immune microenvironment (TIME). While some cytokines are known to be universally upregulated in TIME, the unique cytokine expression patterns have not been fully resolved in specific types of cancers. To address this challenge, we develop a TIME single-cell RNA sequencing (scRNA-seq) dataset, which is designed to study cytokine expression patterns for precise cancer classification...
February 6, 2024: Computational Biology and Chemistry
https://read.qxmd.com/read/38327880/identification-of-cd8-t-cell-dysfunction-associated-with-symptoms-in-myalgic-encephalomyelitis-chronic-fatigue-syndrome-me-cfs-and-long-covid-and-treatment-with-a-nebulized-antioxidant-anti-pathogen-agent-in-a-retrospective-case-series
#14
JOURNAL ARTICLE
Anna Gil, George E Hoag, John P Salerno, Mady Hornig, Nancy Klimas, Liisa K Selin
BACKGROUND: Patients with post-acute sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection (PASC, i.e., Long COVID) have a symptom complex highly analogous to many features of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), suggesting they may share some aspects of pathogenesis in these similar disorders. ME/CFS is a complex disease affecting numerous organ systems and biological processes and is often preceded by an infection-like episode. It is postulated that the chronic manifestations of illness may result from an altered host response to infection or inability to resolve inflammation, as is being reported in Long COVID...
March 2024: Brain, behavior, & immunity health
https://read.qxmd.com/read/38316183/ockham-s-razor-the-application-of-parsimonious-medicine-in-allergy-immunology
#15
JOURNAL ARTICLE
John O Warner
The spectacular advances of modern medicine have distracted clinicians from applying the age-old principles of thorough history and examination followed by only ordering tests relevant to the patient's presentation. The most obvious diagnosis is the most likely and should be addressed first. Ockham's razor, or parsimonious medicine, should be applied because plurality of diagnoses is less likely than a single explanation. Component resolved diagnostics and highly effective biological therapies for allergy/immune mediated diseases have been highly effective when used by specialist allergy services...
February 3, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38311961/heterogeneity-of-sensitization-profiles-and-clinical-phenotypes-among-patients-with-seasonal-allergic-rhinitis-in-southern-european-countries-the-it-2020-multicenter-study
#16
JOURNAL ARTICLE
S Dramburg, U Grittner, E Potapova, A Travaglini, S Tripodi, S Arasi, S Pelosi, A Acar Şahin, X Aggelidis, A Barbalace, A Bourgoin, B Bregu, M A Brighetti, E Caeiro, S Caglayan Sozmen, L Caminiti, D Charpin, M Couto, L Delgado, A Di Rienzo Businco, C Dimier, M V Dimou, J A Fonseca, O Goksel, D Hernandez, C J Hernandez Toro, T M Hoffmann, D T Jang, F Kalpaklioglu, B Lame, R Llusar, M Makris, A Mazon, E Mesonjesi, A Nieto, A B Öztürk, L Pahus, G Pajno, I Panasiti, N G Papadopoulos, E Pellegrini, A M Pereira, M Pereira, N M Pinar, A Priftanji, F Psarros, C Sackesen, I Sfika, J Suarez, M Thibaudon, U Uguz, V Verdier, V Villella, P Xepapadaki, D Yazici, P M Matricardi
BACKGROUND: Pollen allergy poses a significant health and economic burden in Europe. Disease patterns are relatively homogeneous within Central and Northern European countries. However, no study broadly assessed the features of seasonal allergic rhinitis (SAR) across different Southern European countries with a standardized approach. OBJECTIVE: To describe sensitization profiles and clinical phenotypes of pollen allergic patients in nine Southern European cities with a uniform methodological approach...
February 5, 2024: Allergy
https://read.qxmd.com/read/38303627/characterisation-of-paediatric-brain-tumours-by-their-mrs-metabolite-profiles
#17
JOURNAL ARTICLE
Simrandip K Gill, Heather E L Rose, Martin Wilson, Daniel Rodriguez Gutierrez, Lara Worthington, Nigel P Davies, Lesley MacPherson, Darren R Hargrave, Dawn E Saunders, Christopher A Clark, Geoffrey S Payne, Martin O Leach, Franklyn A Howe, Dorothee P Auer, Tim Jaspan, Paul S Morgan, Richard G Grundy, Shivaram Avula, Barry Pizer, Theodoros N Arvanitis, Andrew C Peet
1 H-magnetic resonance spectroscopy (MRS) has the potential to improve the noninvasive diagnostic accuracy for paediatric brain tumours. However, studies analysing large, comprehensive, multicentre datasets are lacking, hindering translation to widespread clinical practice. Single-voxel MRS (point-resolved single-voxel spectroscopy sequence, 1.5 T: echo time [TE] 23-37 ms/135-144 ms, repetition time [TR] 1500 ms; 3 T: TE 37-41 ms/135-144 ms, TR 2000 ms) was performed from 2003 to 2012 during routine magnetic resonance imaging for a suspected brain tumour on 340 children from five hospitals with 464 spectra being available for analysis and 281 meeting quality control...
February 1, 2024: NMR in Biomedicine
https://read.qxmd.com/read/38282198/sensitization-profiles-to-house-dust-mite-dermatophagoides-pteronyssinus-molecular-allergens-in-the-lithuanian-population-understanding-allergic-sensitization-patterns
#18
JOURNAL ARTICLE
Gabija Biliute, Monika Miskinyte, Asta Miskiniene, Aukse Zinkeviciene, Violeta Kvedariene
BACKGROUND: House dust mite (HDM) allergy is a prevalent global health concern, with varying sensitization profiles observed across populations. We aimed to provide a comprehensive assessment of molecular allergen sensitization patterns in the Lithuanian population, with a focus on Dermatophagoides pteronyssinus (Der p), and investigate patterns of concomitant reactivity among different allergens to enhance the accuracy of HDM allergy diagnostics. METHODS: A comprehensive analysis of 1520 patient test results in Lithuania from 2020 to 2022 was performed...
January 2024: Clinical and Translational Allergy
https://read.qxmd.com/read/38248061/motion-contrast-phase-gradient-and-simultaneous-oct-images-assist-in-the-interpretation-of-dark-field-images-in-eyes-with-retinal-pathology
#19
JOURNAL ARTICLE
Mircea Mujat, Konstantina Sampani, Ankit H Patel, Ronald Zambrano, Jennifer K Sun, Gadi Wollstein, R Daniel Ferguson, Joel S Schuman, Nicusor Iftimia
The cellular-level visualization of retinal microstructures such as blood vessel wall components, not available with other imaging modalities, is provided with unprecedented details by dark-field imaging configurations; however, the interpretation of such images alone is sometimes difficult since multiple structural disturbances may be present in the same time. Particularly in eyes with retinal pathology, microstructures may appear in high-resolution retinal images with a wide range of sizes, sharpnesses, and brightnesses...
January 15, 2024: Diagnostics
https://read.qxmd.com/read/38238524/a-modular-chemoenzymatic-cascade-strategy-for-the-structure-customized-assembly-of-ganglioside-analogs
#20
JOURNAL ARTICLE
Xuefeng Jin, Hanchao Cheng, Xiaohui Chen, Xuefeng Cao, Cong Xiao, Fengling Ding, Huirong Qu, Peng George Wang, Yan Feng, Guang-Yu Yang
Gangliosides play vital biological regulatory roles and are associated with neurological system diseases, malignancies, and immune deficiencies. They have received extensive attention in developing targeted drugs and diagnostic markers. However, it is difficult to obtain enough structurally defined gangliosides and analogs especially at an industrial-relevant scale, which prevent exploring structure-activity relationships and identifying drug ingredients. Here, we report a highly modular chemoenzymatic cascade assembly (MOCECA) strategy for customized and large-scale synthesis of ganglioside analogs with various glycan and ceramide epitopes...
January 18, 2024: Communications Chemistry
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