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Component resolved diagnostics

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https://www.readbyqxmd.com/read/29753496/an-evidence-based-protocol-for-managing-neonatal-middle-ear-effusions-in-babies-who-fail-newborn-hearing-screening
#1
Brittany C Weber, Scott M Whitlock, Kaidi He, Blake S Kimbrell, Craig S Derkay
OBJECTIVES: To evaluate the prevalence of middle ear disease in infants referred for failed newborn hearing screening (NBHS) and to review patient outcomes after intervention in order to propose an evidence-based protocol for management of newborns with otitis media with effusion (OME) who fail NBHS. METHODS: 85 infants with suspected middle ear pathology were retrospectively reviewed after referral for failed NBHS. All subjects underwent a diagnostic microscopic exam with myringotomy with or without placement of a ventilation tube in the presence of a middle ear effusion and had intra-operative auditory brainstem response (ABR) testing or testing at a later date...
April 12, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29729157/the-research-of-medical-and-social-factors-of-the-risk-of-reproductive-health-of-men-by-family-doctor
#2
Serhii Yu Tsiporenko, Larysa F Matyucha
OBJECTIVE: Introduction: One of the important modern problems in the practice of a family doctor is the protection of reproductive health. Reproductive problems in marriage, including male infertility, are important components of demographic processes, therefore, attempts to resolve them are not only medical, but also social significance. Of all the physiological systems of man, for which the patterns of adaptation mechanisms are shown, the most "vulnerable" is the reproductive system, whose functioning depends on the set of exo- and endogenous influences...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29666553/the-potential-of-component-resolved-diagnosis-in-laboratory-diagnostics-of-allergy
#3
REVIEW
Slavica Dodig, Ivana Čepelak
The initial laboratory approach in the diagnosis of allergies is to detect the type of allergic reaction, i.e. whether the patient's allergy is mediated by immunoglobulin E (IgE) or not. For this purpose, the concentration of total serum IgE (tIgE) and specific IgE (sIgE) are determined. Progress in laboratory diagnostics is the use of component-resolved diagnosis (CRD) which implies determination of sIgE against purified native and recombinant allergenic molecules. Component-resolved diagnosis is used in laboratory practice as singleplex and multiplex assays...
June 15, 2018: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/29643919/an-update-on-molecular-cat-allergens-fel-d-1-and-what-else-chapter-1-fel-d-1-the-major-cat-allergen
#4
REVIEW
B Bonnet, K Messaoudi, F Jacomet, E Michaud, J L Fauquert, D Caillaud, B Evrard
Background: Cats are the major source of indoor inhalant allergens after house dust mites. The global incidence of cat allergies is rising sharply, posing a major public health problem. Ten cat allergens have been identified. The major allergen responsible for symptoms is Fel d 1, a secretoglobin and not a lipocalin, making the cat a special case among mammals. Main body: Given its clinical predominance, it is essential to have a good knowledge of this allergenic fraction, including its basic structure, to understand the new exciting diagnostic and therapeutic applications currently in development...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29618933/current-perspectives-on-tree-nut-allergy-a-review
#5
REVIEW
Tamar Weinberger, Scott Sicherer
Tree nut (TN) allergy is common and often severe. It has become an important health concern as availability and consumption have increased. Prevalence varies by age and geographic region and appears to have increased in children. Accidental ingestion of TNs is common. Unfortunately, there is a lower likelihood of resolution of TN allergy, roughly 10%. TN-specific skin tests and serum immunoglobulin E levels can help aid in the diagnosis of TN allergy, but a careful medical history is important because a positive test in isolation is not typically diagnostic...
2018: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/29618136/the-role-of-ultrasound-defined-tenosynovitis-and-synovitis-in-the-prediction-of-rheumatoid-arthritis-development
#6
Ilfita Sahbudin, Luke Pickup, Peter Nightingale, Gina Allen, Zaeem Cader, Ruchir Singh, Paola de Pablo, Christopher D Buckley, Karim Raza, Andrew Filer
Objectives: Tenosynovitis (TS) is common in early arthritis. However, the value of US-defined TS in predicting RA development is unclear. We assessed the predictive utility of US-defined TS alongside US-defined synovitis and clinical and serological variables in a prospective cohort of early arthritis patients. Methods: One hundred and seven patients with clinically apparent synovitis of one or more joint and symptom duration ⩽3 months underwent baseline clinical, laboratory and US assessment of 19 bilateral joint sites and 16 bilateral tendon compartments...
April 3, 2018: Rheumatology
https://www.readbyqxmd.com/read/29601353/how-to-diagnose-food-allergy
#7
Sakura Sato, Noriyuki Yanagida, Motohiro Ebisawa
PURPOSE OF REVIEW: To assess the recent studies that focus on specific immunoglobulin E (sIgE) testing and basophil activation test (BAT) for diagnosing IgE-mediated food allergies. RECENT FINDINGS: The sIgE to allergen extract or component can predict reactivity to food. The cutoff value based on the positive predictive value (PPV) of sIgE can be considered whenever deciding whether oral food challenge (OFC) is required to diagnose hen's egg, cow's milk, wheat, peanut, and cashew nut allergy...
June 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29578652/non-celiac-gluten-sensitivity-how-its-gut-immune-activation-and-potential-dietary-management-differ-from-celiac-disease
#8
REVIEW
Vera Rotondi Aufiero, Alessio Fasano, Giuseppe Mazzarella
Non-celiac gluten sensitivity (NCGS) is a clinical entity triggered by the ingestion of gluten-containing grains leading to intestinal and/or extraintestinal symptoms that resolve once the gluten-containing foodstuff is eliminated from the diet and it is diagnosed when celiac disease (CD) and wheat allergy (WA) have been ruled out. The limited knowledge about the pathophysiology of NCGS and the lack of validated biomarkers are still major limitations for clinical studies, making it difficult to differentiate NCGS from other gluten-related disorders (GRD)...
March 26, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29569217/mri-evaluation-of-peripheral-vascular-anomalies-using-time-resolved-imaging-of-contrast-kinetics-tricks-sequence
#9
Nicolò Schicchi, Corrado Tagliati, Giacomo Agliata, Paolo Esposto Pirani, Raffaella Spadari, Andrea Giovagnoni
INTRODUCTION: We describe the use of time-resolved imaging of contrast kinetics (TRICKS) sequence in the diagnosis of Peripheral Vascular Anomalies. In case of suspected vascular malformations time-resolved MR angiography might add important information for therapeutic decisions and follow-up. OBJECTIVE: The objective of our study was to assess the usefulness and diagnostic performance of time-resolved imaging of contrast kinetics sequence in the evaluation of peripheral vascular anomalies...
March 22, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29518421/mast-cell-activation-test-in-the-diagnosis-of-allergic-disease-and-anaphylaxis
#10
Rajia Bahri, Adnan Custovic, Peter Korosec, Marina Tsoumani, Martin Barron, Jiakai Wu, Rebekah Sayers, Alf Weimann, Monica Ruiz-Garcia, Nandinee Patel, Abigail Robb, Mohamed H Shamji, Sara Fontanella, Mira Silar, E N Clare Mills, Angela Simpson, Paul J Turner, Silvia Bulfone-Paus
BACKGROUND: Food allergy is an increasing public health issue and the most common cause of life-threatening anaphylactic reactions. Conventional allergy tests assess for the presence of allergen-specific IgE, significantly overestimating the rate of true clinical allergy and resulting in overdiagnosis and adverse effect on health-related quality of life. OBJECTIVE: To undertake initial validation and assessment of a novel diagnostic tool, we used the mast cell activation test (MAT)...
March 5, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29489807/20-khz-ch-2-o-and-oh-plif-with-stereo-piv
#11
Stephen D Hammack, Campbell D Carter, Aaron W Skiba, Christopher A Fugger, Josef J Felver, Joseph D Miller, James R Gord, Tonghun Lee
Planar laser-induced fluorescence (PLIF) of hydroxyl (OH) and formaldehyde (CH2 O) radicals was performed alongside stereo particle image velocimetry (PIV) at a 20 kHz repetition rate in a highly turbulent Bunsen flame. A dual-pulse burst-mode laser generated envelopes of 532 nm pulse pairs for PIV as well as a pair of 355 nm pulses, the first of which was used for CH2 O PLIF. A diode-pumped solid-state Nd:YAG/dye laser system produced the excitation beam for the OH PLIF. The combined diagnostics produced simultaneous, temporally resolved two-dimensional fields of OH and CH2 O and two-dimensional, three-component velocity fields, facilitating the observation of the interaction of fluid dynamics with flame fronts and preheat layers...
March 1, 2018: Optics Letters
https://www.readbyqxmd.com/read/29445888/addressing-molecular-diagnosis-of-occupational-allergies
#12
REVIEW
Monika Raulf, Santiago Quirce, Olivier Vandenplas
PURPOSE OF REVIEW: Numerous clinically relevant allergenic molecules enhance the performance of specific (s) IgE tests and improve the specificity of allergy diagnosis. This review aimed to summarize our current knowledge of the high-molecular-weight allergens involved in the development of occupational asthma and rhinitis and to critically analyze the contribution of component-resolved diagnosis in the management of these conditions. RECENT FINDINGS: There is a lack of standardization and validation for most available extracts of occupational agents, and assessment of sIgE reactivity to occupational allergen components has been poorly investigated, with the notable exception of natural rubber latex (NRL) and wheat flour...
February 14, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29413339/current-insights-in-allergen-immunotherapy
#13
REVIEW
Giovanni Passalacqua, Diego Bagnasco, Matteo Ferrando, Enrico Heffler, Francesca Puggioni, Giorgio Walter Canonica
OBJECTIVE: Allergen-specific immunotherapy (AIT) in its subcutaneous and sublingual forms is currently a well-established and experimentally supported treatment for respiratory allergy and hymenoptera venom allergy. There have been advances in its use linked strictly to the advancement in the knowledge of the molecular mechanisms of allergy, the production of well-characterized extracts, and diagnostic techniques. The use of AIT in asthma and the application of new approaches are expanding...
February 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29411550/dog-and-cat-allergies-current-state-of-diagnostic-approaches-and-challenges
#14
REVIEW
Sanny K Chan, Donald Y M Leung
Allergies to dogs and cats affect 10%-20% of the population worldwide and is a growing public health concern as these rates increase. Given the prevalence of detectable dog and cat allergens even in households without pets, there is a critical need to accurately diagnose and treat patients to reduce morbidity and mortality from exposure. The ability to diagnose cat sensitization is good, in contrast to dogs. Component resolved diagnostics of sensitization to individual allergenic proteins will dramatically improve diagnosis...
March 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29377469/component-resolved-diagnostics-demonstrates-that-most-peanut-allergic-individuals-could-potentially-introduce-tree-nuts-to-their-diet
#15
R Uotila, A K Kukkonen, W M Blom, B Remington, J Westerhout, A S Pelkonen, M J Mäkelä
BACKGROUND: Nut allergy varies from pollen cross-allergy, to primary severe allergy with life-threatening symptoms. The screening of IgE antibodies to a wide spectrum of allergens, including species-specific and cross-reactive allergens, is made possible via microarray analysis. OBJECTIVE: We sought to study the association of variable IgE sensitization profiles to clinical response in peanut-challenged children and adolescents in a birch-endemic region. In addition, we studied the avoidance of tree nuts and species-specific sensitizations...
January 29, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29372197/a-method-for-the-quantitative-extraction-of-gold-nanoparticles-from-human-bronchoalveolar-lavage-fluids-through-a-glycerol-gradient
#16
Dimitrios Bitounis, Vincent Barnier, Cyril Guibert, Jérémie Pourchez, Valérie Forest, Delphine Boudard, Jean-François Hochepied, Pierre Chelle, Jean-Michel Vergnon, Michèle Cottier
Bronchoalveolar lavage (BAL) is a diagnostic procedure which samples the cellular and non-cellular components of the pulmonary epithelial surface. The inherent biological noise of BAL fluids inhibits their direct mineralogical analysis while currently available particle retrieval protocols are suspected to impose quantitative and qualitative bias on the studied particle load. This study presents a simple method for the near-lossless extraction of citrate-capped gold nanoparticles from human BAL fluids at sub-ppm levels which enables their quantitation and surface characterization...
February 8, 2018: Nanoscale
https://www.readbyqxmd.com/read/29358620/the-high-molecular-weight-dipeptidyl-peptidase-iv-pol-d-3-is-a-major-allergen-of-polistes-dominula-venom
#17
Maximilian Schiener, Christiane Hilger, Bernadette Eberlein, Mariona Pascal, Annette Kuehn, Dominique Revets, Sébastien Planchon, Gunilla Pietsch, Pilar Serrano, Carmen Moreno-Aguilar, Federico de la Roca, Tilo Biedermann, Ulf Darsow, Carsten B Schmidt-Weber, Markus Ollert, Simon Blank
Hymenoptera venom allergy can cause severe anaphylaxis in untreated patients. Polistes dominula is an important elicitor of venom allergy in Southern Europe as well as in the United States. Due to its increased spreading to more moderate climate zones, Polistes venom allergy is likely to gain importance also in these areas. So far, only few allergens of Polistes dominula venom were identified as basis for component-resolved diagnostics. Therefore, this study aimed to broaden the available panel of important Polistes venom allergens...
January 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29331514/employment-of-proteomic-and-immunological-based-methods-for-the-identification-of-catalase-as-novel-allergen-from-banana
#18
Jasna Nikolić, Andrijana Nešić, Skadi Kull, Frauke Schocker, Uta Jappe, Marija Gavrović-Jankulović
Diagnostic reagents based on food allergen extracts often lack sufficient sensitivity. The introduction of well characterized food allergens in molecular allergy diagnosis has been recognized as valid approach to circumvent unstandardized allergen extracts. Banana fruit (Musa acuminata) is a well-established allergen source which besides six characterized allergens, contains unidentified IgE reactive proteins whose clinical relevance remains undefined. By employment of a combinatorial peptide ligand library (CPLL) methodology with 2-D PAGE, mass spectrometric and 2-D immunoblot analysis, a novel allergen from banana fruit was detected in banana as catalase...
March 20, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29331065/component-resolved-diagnostics-to-direct-in-venom-immunotherapy-important-steps-towards-precision-medicine
#19
REVIEW
S Blank, M B Bilò, M Ollert
Stings of Hymenoptera can induce IgE-mediated systemic and even fatal allergic reactions. Venom-specific immunotherapy (VIT) is the only disease-modifying and curative treatment of venom allergy. However, choosing the correct venom for VIT represents a necessary prerequisite for efficient protection against further anaphylactic sting reactions after VIT. In the past, therapeutic decisions based on the measurement of specific IgE (sIgE) levels to whole venom extracts were not always straightforward, especially when the patient was not able to identify the culprit insect...
April 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29327915/multispectral-atomic-force-microscopy-infrared-nano-imaging-of-malaria-infected-red-blood-cells
#20
David Perez-Guaita, Kamila Kochan, Mitchell Batty, Christian Doerig, Jose Garcia-Bustos, Shirly Espinoza, Don McNaughton, Phil Heraud, Bayden R Wood
Atomic force microscopy-infrared (AFM-IR) spectroscopy is a powerful new technique that can be applied to study molecular composition of cells and tissues at the nanoscale. AFM-IR maps are acquired using a single wavenumber value: they show either the absorbance plotted against a single wavenumber value or a ratio of two absorbance values. Here, we implement multivariate image analysis to generate multivariate AFM-IR maps and use this approach to resolve subcellular structural information in red blood cells infected with Plasmodium falciparum at different stages of development...
March 6, 2018: Analytical Chemistry
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