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https://www.readbyqxmd.com/read/27695667/deceleration-of-probe-beam-by-stage-bias-potential-improves-resolution-of-serial-block-face-scanning-electron-microscopic-images
#1
James C Bouwer, Thomas J Deerinck, Eric Bushong, Vadim Astakhov, Ranjan Ramachandra, Steven T Peltier, Mark H Ellisman
Serial block-face scanning electron microscopy (SBEM) is quickly becoming an important imaging tool to explore three-dimensional biological structure across spatial scales. At probe-beam-electron energies of 2.0 keV or lower, the axial resolution should improve, because there is less primary electron penetration into the block face. More specifically, at these lower energies, the interaction volume is much smaller, and therefore, surface detail is more highly resolved. However, the backscattered electron yield for metal contrast agents and the backscattered electron detector sensitivity are both sub-optimal at these lower energies, thus negating the gain in axial resolution...
2017: Advanced Structural and Chemical Imaging
https://www.readbyqxmd.com/read/26635802/molecular-and-translational-classifications-of-damps-in-immunogenic-cell-death
#2
Abhishek D Garg, Lorenzo Galluzzi, Lionel Apetoh, Thais Baert, Raymond B Birge, José Manuel Bravo-San Pedro, Karine Breckpot, David Brough, Ricardo Chaurio, Mara Cirone, An Coosemans, Pierre G Coulie, Dirk De Ruysscher, Luciana Dini, Peter de Witte, Aleksandra M Dudek-Peric, Alberto Faggioni, Jitka Fucikova, Udo S Gaipl, Jakub Golab, Marie-Lise Gougeon, Michael R Hamblin, Akseli Hemminki, Martin Herrmann, James W Hodge, Oliver Kepp, Guido Kroemer, Dmitri V Krysko, Walter G Land, Frank Madeo, Angelo A Manfredi, Stephen R Mattarollo, Christian Maueroder, Nicolò Merendino, Gabriele Multhoff, Thomas Pabst, Jean-Ehrland Ricci, Chiara Riganti, Erminia Romano, Nicole Rufo, Mark J Smyth, Jürgen Sonnemann, Radek Spisek, John Stagg, Erika Vacchelli, Peter Vandenabeele, Lien Vandenberk, Benoit J Van den Eynde, Stefaan Van Gool, Francesca Velotti, Laurence Zitvogel, Patrizia Agostinis
The immunogenicity of malignant cells has recently been acknowledged as a critical determinant of efficacy in cancer therapy. Thus, besides developing direct immunostimulatory regimens, including dendritic cell-based vaccines, checkpoint-blocking therapies, and adoptive T-cell transfer, researchers have started to focus on the overall immunobiology of neoplastic cells. It is now clear that cancer cells can succumb to some anticancer therapies by undergoing a peculiar form of cell death that is characterized by an increased immunogenic potential, owing to the emission of the so-called "damage-associated molecular patterns" (DAMPs)...
2015: Frontiers in Immunology
https://www.readbyqxmd.com/read/26521882/adaptive-management-of-invasive-pests-in-natural-protected-areas-the-case-of-matsucoccus-feytaudi-in-central-italy
#3
A Sciarretta, L Marziali, M Squarcini, L Marianelli, D Benassai, F Logli, P F Roversi
Invasive species are a significant threat to affected ecosystems, having serious environmental, economic and social impacts. The maritime pine bast scale, Matsucoccus feytaudi Ducasse (Hemiptera: Matsucoccidae), causes serious damage to Pinus pinaster forests in SE France, Corsica and Italy where it has been introduced. This study illustrates the adaptive management plan implemented in the Migliarino, San Rossore, Massaciuccoli Regional Natural Park in Tuscany, Italy, where M. feytaudi arrived in 2004, leading to the decay of local P...
February 2016: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/26326956/human-classifier-can-individuals-deduce-which-task-someone-was-performing-based-solely-on-their-eye-movements
#4
Michael Dodd, Brett Bahle, Mark Mills, Monica Rosen, Gerald McDonnell, Joseph MacInnes
Numerous investigations have revealed that eye movements and fixation locations differ as a function of how an individual is processing a scene (e.g., Castelhano et al., 2009; Dodd et al., 2009; Land & Hayhoe, 2001; Mills et al., 2011, Yarbus, 1967). As a consequence, a common question of interest is whether a participant's task can be predicted from their observed pattern of eye movements. To that end, a number of researchers have taken a cue from the machine learning literature and attempted to train a task set classifier with varying degrees of success (e...
2015: Journal of Vision
https://www.readbyqxmd.com/read/24669745/lack-of-energetic-equivalence-in-forest-soil-invertebrates
#5
Roswitha B Ehnes, Melanie M Pollierer, Georgia Erdmann, Bernhard Klarner, Bernhard Eitzinger, Christoph Digel, David Ott, Mark Maraun, Stefan Scheu, Ulrich Brose
Ecological communities consist of small abundant and large non-abundant species. The energetic equivalence rule is an often-observed pattern that could be explained by equal energy usage among abundant small organisms and non-abundant large organisms. To generate this pattern, metabolism (as an indicator of individual energy use) and abundance have to scale inversely with body mass, and cancel each other out. In contrast, the pattern referred to as biomass equivalence states that the biomass of all species in an area should be constant across the body-mass range...
February 2014: Ecology
https://www.readbyqxmd.com/read/24497818/jumping-and-landing-techniques-in-elite-women-s-volleyball
#6
Mark D Tillman, Chris J Hass, Denis Brunt, Gregg R Bennett
Volleyball has become one of the most widely played participant sports in the world. Participation requires expertise in many physical skills and performance is often dependent on an individual's ability to jump and land. The incidence of injury in volleyball is similar to the rates reported for sports that are considered more physical contact sports. Though the most common source of injury in volleyball is the jump landing sequence, little research exists regarding the prevalence of jumping and landing techniques...
March 2004: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/24228458/-the-efficacy-of-ultrasound-guided-infraorbital-nerve-block-with-hockey-stick-typed-probe
#7
Naoto Iwase, Hidekimi Fukui, Youko Yuunaiyama, Kouki Kaneko, Kiyoshige Ohseto, Hiroyuki Uchino
We report a case of ultrasound-guided infraorbital nerve block with a hockey stick typed probe in plane approach. Individual difference of infraorbital anatomy makes it difficult to puncture the infraorbital for a man, and the risks include bleeding, double vision and paranasal sinus puncture. The advantage of ultrasound-guided nerve block has been reported. Compared with conventional land mark method approach, ultrasound technique is thought to be easy to perform, more quickly and safely without any complications...
October 2013: Masui. the Japanese Journal of Anesthesiology
https://www.readbyqxmd.com/read/22031565/prairie-grass-establishment-on-calcareous-reclaimed-mine-soil
#8
Mark Thorne, John Cardina
Reclaimed Appalachian surface mined lands have difficulty in sustaining native deciduous forest communities. Establishing prairie communities could increase ecosystem function; however, a native model system does not exist. We evaluated establishment of 15 North American prairie grasses as monocultures on reclaimed mine soil in southeast Ohio in four randomized complete blocks planted May 2005 and 2006. Population density was assessed 30 d after planting (30 DAP) and in October of the planting year (YR1) and second year following planting (YR2) and expressed as percentage of viable seeds sown (PVSS)...
November 2011: Journal of Environmental Quality
https://www.readbyqxmd.com/read/19936221/oxidative-stress-impairs-the-heat-stress-response-and-delays-unfolded-protein-recovery
#9
Masaaki Adachi, Yaohua Liu, Kyoko Fujii, Stuart K Calderwood, Akira Nakai, Kohzoh Imai, Yasuhisa Shinomura
BACKGROUND: Environmental changes, air pollution and ozone depletion are increasing oxidative stress, and global warming threatens health by heat stress. We now face a high risk of simultaneous exposure to heat and oxidative stress. However, there have been few studies investigating their combined adverse effects on cell viability. PRINCIPAL FINDINGS: Pretreatment of hydrogen peroxide (H(2)O(2)) specifically and highly sensitized cells to heat stress, and enhanced loss of mitochondrial membrane potential...
2009: PloS One
https://www.readbyqxmd.com/read/19935105/kinematic-and-kinetic-comparisons-of-elite-and-well-trained-sprinters-during-sprint-start
#10
COMPARATIVE STUDY
Jean Slawinski, Alice Bonnefoy, Jean-Michel Levêque, Guy Ontanon, Annie Riquet, Raphaël Dumas, Laurence Chèze
The purpose of this study was to compare the main kinematic, kinetic, and dynamic parameters of elite and well-trained sprinters during the starting block phase and the 2 subsequent steps. Six elite sprinters (10.06-10.43 s/100 m) and 6 well-trained sprinters (11.01-11.80 s/100 m) equipped with 63 passive reflective markers performed 4 maximal 10 m sprint starts on an indoor track. An opto-electronic motion analysis system consisting of 12 digital cameras (250 Hz) was used to record 3D marker trajectories. At the times "on your marks," "set," "clearing the block," and "landing and toe-off of the first and second step," the horizontal position of the center of mass (CM), its velocity (XCM and VCM), and the horizontal position of the rear and front hand (X(Hand_rear) and X(Hand_front)) were calculated...
April 2010: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/19460433/estrogen-receptor-beta-erbeta-subtype-specific-ligands-increase-transcription-p44-p42-mitogen-activated-protein-kinase-mapk-activation-and-growth-in-human-non-small-cell-lung-cancer-cells
#11
Pamela A Hershberger, Laura P Stabile, Beatriz Kanterewicz, Mary E Rothstein, Chris T Gubish, Stephanie Land, Yongli Shuai, Jill M Siegfried, Mark Nichols
In non-small cell lung cancer (NSCLC) cells, 17beta-estradiol increases transcription, activates MAPK, and stimulates proliferation. We hypothesize that estrogen receptor beta (ERbeta) mediates these responses because it, but not ERalpha, is detected in our NSCLC cell lines. To test this, we determined the effects of the ERbeta-selective agonists genistein (GEN) and 2,3-bis(4-hydroxyphenyl)propionitrile (DPN) and the ERalpha-selective agonist 4,4',4''-(4-propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol (PPT) in 201T cells...
August 2009: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/19241916/immunosuppression-in-pancreas-transplantation-the-euro-spk-trials-and-beyond
#12
REVIEW
J Malaise, A De Roover, J P Squifflet, W Land, P Neuhaus, J Pratschke, A Kahl, A Pascher, S Boas-Knoop, H Arbogast, J Hoffmann, W D Illner, Seissler, Schlamp, Viebahn, Wunsch, Hajt, E Klar, W Scharek, Hopt, P Pisarski, O Drognitz, C Thurow, K Dette, W O Bechstein, G Woeste, J Klempnauer, T Becker, Lück, Neipp, A Königsrainer, W Steurer, R Margreiter, Mark, Bonatti, F Saudek, P Boucek, M Adamec, T Havrdova, R Koznarova, Y Vanrenterghem, J Pirenne, B Maes, D Kuypers, W Coosemans, P Evenepoel, D van Ophem, V Marcelis, van Vlem, Peeters, de Hemptinne, de Roose, L Fernandez-Cruz, M J Ricart, R Nakache, P Morel, T Berney, S Demuylder
The Immunosuppression in Pancreas Transplantation was historically based on the fact that the pancreas is an extremely immunogenic organ. Quadruple drug therapy with polyclonal or monoclonal antibodies induction was the mainstay therapy since the introduction of Cyclosporine A. In the modern era of Immunosuppression, Mycophenolate Mofetil replaced Azathioprine while Tacrolimus-another potent calcineurin inhibitor-had-and still has-a difficult challenge to replaced Cyclosporine A, due to its potential diabetogenic effect...
November 2008: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/17972731/-as-soon-as-the-bat-met-the-ball-i-knew-it-was-gone-outcome-prediction-hindsight-bias-and-the-representation-and-control-of-action-in-expert-and-novice-baseball-players
#13
Rob Gray, Sun L Beilock, Thomas H Carr
A virtual-reality batting task compared novice and expert baseball players' ability to predict the outcomes of their swings as well as the susceptibility of these outcome predictions to hindsight bias--a measure of strength and resistance to distortion of memory for predicted action outcomes. During each swing the simulation stopped when the bat met the ball. Batters marked where on the field they thought the ball would land. Correct feedback was then displayed, after which batters attempted to remark the location they had indicated prior to feedback...
August 2007: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/11574879/the-landing-of-the-near-shoemaker-spacecraft-on-asteroid-433-eros
#14
J Veverka, B Farquhar, M Robinson, P Thomas, S Murchie, A Harch, P G Antreasian, S R Chesley, J K Miller, W M Owen, B G Williams, D Yeomans, D Dunham, G Heyler, M Holdridge, R L Nelson, K E Whittenburg, J C Ray, B Carcich, A Cheng, C Chapman, J F Bell, M Bell, B Bussey, B Clark, D Domingue, M J Gaffey, E Hawkins, N Izenberg, J Joseph, R Kirk, P Lucey, M Malin, L McFadden, W J Merline, C Peterson, L Prockter, J Warren, D Wellnitz
The NEAR-Shoemaker spacecraft was designed to provide a comprehensive characterization of the S-type asteroid 433 Eros (refs 1,2,3), an irregularly shaped body with approximate dimensions of 34 x 13 x 13 km. Following the completion of its year-long investigation, the mission was terminated with a controlled descent to its surface, in order to provide extremely high resolution images. Here we report the results of the descent on 12 February 2001, during which 70 images were obtained. The landing area is marked by a paucity of small craters and an abundance of 'ejecta blocks'...
September 27, 2001: Nature
https://www.readbyqxmd.com/read/11334835/transgenic-mice-overexpressing-human-kvlqt1-dominant-negative-isoform-part-i-phenotypic-characterisation
#15
S Demolombe, G Lande, F Charpentier, M A van Roon, M J van den Hoff, G Toumaniantz, I Baro, G Guihard, N Le Berre, A Corbier, J de Bakker, T Opthof, A Wilde, A F Moorman, D Escande
OBJECTIVES: The KCNQ1 gene encodes the KvLQT1 potassium channel, which generates in the human heart the slow component of the cardiac delayed rectifier current, I(Ks). Mutations in KCNQ1 are the most frequent cause of the congenital long QT syndrome. We have previously cloned a cardiac KCNQ1 human isoform, which exerts a strong dominant-negative effect on KvLQT1 channels. We took advantage of this dominant-negative isoform to engineer an in vivo model of KvLQT1 disruption, obtained by overexpressing the dominant-negative subunit under the control of the alpha-myosin heavy chain promoter...
May 2001: Cardiovascular Research
https://www.readbyqxmd.com/read/8234022/antinociceptive-effects-of-the-enkephalinase-inhibitor-sch-34826-in-the-snail-cepaea-nemoralis
#16
L M Saksida, L A Galea, M Kavaliers
In vertebrates the effects of endogenous opioid peptides are limited by proteolytic enzymes such as endopeptidase 24.11 (enkephalinase), which cleaves the Gly-Phe bonds in both methionine- and leucine-enkephalin. SCH 34826 ((S)-N-[n-[1-[(2,2-dimethyl-1,3-dioxolan-4yl) methoxy]carbonyl]-2-phenylethyl]-L-phenylalanine-B-alanine) is a potent, highly specific, enkephalinase inhibitor that has marked analgesic effects in mammals. The present study examined the effects of SCH 34826 on opioid-mediated aversive thermal (nociceptive) response of an invertebrate, the land snail, Cepaea nemoralis...
July 1993: Peptides
https://www.readbyqxmd.com/read/2831517/fmrfamide-receptors-in-helix-aspersa
#17
K Payza
An in vitro receptor binding assay and an isolated heart bioassay were developed and used to characterize the structure-activity relations (SAR) of FMRFamide receptors in a land snail, Helix aspersa. In the radioreceptor assay, binding of 125I-desaminoTyr-PhenorLeu-Arg-Phe-amide (125I-daYFnLRFamide) at 0 degrees C to Helix brain membranes was reversible, saturable, and specific, with a KD of 14 nM and a Bmax of 85 fmol/mg brain. A lower affinity site was also observed (KD = 245 nM; Bmax = 575 fmol/mg brain)...
November 1987: Peptides
https://www.readbyqxmd.com/read/117248/transient-b-cell-immaturity-with-intractable-diarrhoea-a-possible-new-immunodeficiency-syndrome
#18
S O Lie, S Frøland, P Brandtzaeg, B Vandvik, J Steen-Johnsen
A male boy is described, who suffered from an intractable diarrhoea and several infections and who died in a severe marasmic state at the age of 8 months. Immunological studies revealed a block in the normal differentiation of B cells to Ig-producing plasma cells. After the age of 5 months, however, this block disappeared, leading to a dramatic increase in circulating Ig, most pronounced in the IgM class. In the intestine, plasma cells could only be detected after the age of 5 months, and then with a marked preponderance of IgM cells...
1978: Journal of Inherited Metabolic Disease
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