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Extra mammary pagets disease

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https://www.readbyqxmd.com/read/27872543/extra-mammary-paget-s-disease-of-vulva-a-case-report
#1
Than Singh Tomar, Suchetha Sambasivan, Rema Prabhakaran Nair, Shaji Thomas, Preethi T Ramadas
Extra mammary Paget's disease (EMPD) is a rare condition involving the vulva, anogenital region, and axilla. Vulvar disease usually presents as a slow growing well-defined itchy plaque with crustations or ulcerations over the affected area in postmenopausal women. Well-established guidelines for diagnosis and management are not available for this rare condition. Our patient is a 64-year-old postmenopausal woman with a history of similar complaints of 2 years duration, not responding to multiple topical treatments...
December 2016: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27760964/-a-case-of-early-anal-canal-cancer-with-pagetoid-spread-with-different-antitumor-effects-of-chemotherapy-on-different-metastatic-sites
#2
Kazuhiko Yoshimatsu, Gakuji Osawa, Hajime Yokomizo, Yuki Yano, Sachiyo Okayama, Akiko Sakuma, Masaya Satake, Yasufumi Yamada, Shinichi Asaka, Takebumi Usui, Kentaro Yamaguchi, Shunichi Shiozawa, Takeshi Shimakawa, Takao Katsube, Yoshihiko Naritaka
A 78-year-old man visited our hospital with a prolapsed hemorrhoid. He was referred to the dermatology unit due to the thickness and redness of the perianal skin. He was diagnosed as having extra mammary Paget's disease by skin biopsy. After a biopsy of the anal polyp was performed to investigate the primary site, he was diagnosed with early anal canal cancer with Pagetoid spread and underwent a radical operation. Abdominoperineal resection with skin(D2 prx D3 lymphadenectomy) was performed with perineal reconstruction using a gracilis muscle graft...
October 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27538143/-primary-penoscrotal-extra-mammary-paget-s-disease-analysis-of-22-cases
#3
Z Q Bao, D Fang, C B Yue, L Cai, T Y Wang, X S Li, L Q Zhou
OBJECTIVE: To investigate the clinical characteristics, treatment and prognosis of primary penoscrotal extra-mammary Paget's disease (PSPD). METHODS: The clinical and pathological data of 22 cases of primary PSPD were retrospectively reviewed. Survival rate of the overall patients, the invasive patients, and the patients with positive surgical margin or negative surgical margin were analyzed with Kaplan-Meier survival curve method. RESULTS: Among all the patients with primary PSPD, the median age of onset was 64...
February 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/26943427/paget-s-disease-of-the-male-breast-a-case-report
#4
Masayuki Akita, Nobuya Kusunoki, Takahiro Nakajima, Shiro Takase, Yoko Maekawa, Kazuyoshi Kajimoto, Masakazu Ohno
The patient was a 91-year-old man with change in nipple appearance, itching and redness, and a palpable breast mass. At presentation, mammary Paget's disease (PD) was clinically suspected. Skin biopsy was performed and showed epidermis invaded by Paget cells, characterized by hyperchromatic nuclei and abundant pale-staining cytoplasm. Computed tomography and mammary ultrasonography confirmed the absence of an underlying invasive carcinoma, and the patient underwent right mastectomy and sentinel lymph node biopsy (SLNB)...
December 2015: Surgical Case Reports
https://www.readbyqxmd.com/read/26233548/double-rarities-double-challenges-extra-mammary-paget-s-disease-and-anal-adenocarcinoma
#5
Sepideh Gholami, Lauren S Y Wood, David Bingham, Cindy Kin
No abstract text is available yet for this article.
April 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/25657432/extra-mammary-paget-s-disease-a-rare-case-report
#6
Vidyadhar R Sardesai, Trupti D Agarwal, Sarita P Sakhalkar
Extramammary Paget's disease is a marginated plaque resembling Paget's disease but occurring in anogenital area, axilla or most commonly on the vulva. A 62-year-old postmenopausal woman presented with extremely pruritic plaque on the perineal skin which progressed gradually over 3 years and did not respond to any topical/systemic steroids, antibiotics, and antifungals. Examination revealed 7 × 8 cm. hypertrophic, verrucous plaque with erosions, and crusts at places. There was no evidence of visceral malignancy...
January 2015: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/25600799/-contribution-of-reflectance-confocal-microscopy-in-the-diagnosis-of-extra-mammary-paget-s-disease
#7
M Suppa, A Marneffe, M Miyamoto, S Rorive, M Boone, V Del Marmol
No abstract text is available yet for this article.
January 2015: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/24385708/locally-recurrent-penile-apocrine-carcinoma-initially-diagnosed-as-metastatic-adenocarcinoma-of-colon
#8
Ok-Jun Lee, Seok-Joong Yun, Wun-Jae Kim, Song-Yi Choi, Ho-Chang Lee, Hyung-Geun Song, Sung-Nam Lim, Ki-Hyeong Lee, Seung-Taik Kim, Hye-Suk Han
Apocrine carcinoma is a rare malignant adnexal neoplasm. The differential diagnosis between apocrine carcinoma and cutaneous metastasis is often difficult. Here, we report a case of locally recurrent penile apocrine carcinoma initially diagnosed as metastatic adenocarcinoma of the colon. A 75-year-old man with a history of surgical resection due to sigmoid colon cancer and penile metastasis two years prior to this study presented with a nodule at the left penile base. He underwent a wide local resection of the penile mass under a suggested preoperative diagnosis of extra-mammary Paget's disease (EMPD) associated with previous sigmoid colon cancer...
December 2013: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/24163070/interventions-for-the-treatment-of-paget-s-disease-of-the-vulva
#9
REVIEW
Katharine A Edey, Ernest Allan, John B Murdoch, Susan Cooper, Andrew Bryant
BACKGROUND: Extra-mammary Paget's disease is a rare form of superficial skin cancer. The most common site of involvement is the vulva. It is seen mainly in postmenopausal white women. Paget's disease of the vulva often spreads in an occult fashion, with margins extending beyond the apparent edges of the lesion. There is a range of interventions from surgical to non-invasive techniques or treatments. The challenges of interventions are to remove or treat disease that may not be visible, without overtreatment and with minimisation of morbidity from radical surgery...
2013: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/23372329/extra-mammary-paget-s-disease-of-the-vulva
#10
Debabrata Barmon, Amal Chandra Kataki, Lima Imchen, Jagannath Dev Sharma
Extra mammary Paget's disease (EMPD) is a rare condition, which affects postmenopausal women. Wide local excision may not be appropriate in elderly patients with extensive disease. It is an uncommon malignant neoplasia with a high local recurrence rate. The standard treatment is local excision of the affected area with adequate margins; however, 40~45% of cases recur after surgery within 4 years. Although surgery is currently considered the preferred primary treatment for EMPD, it has a high relapse rate due to the multifocal nature of the disease...
July 2012: Journal of Mid-life Health
https://www.readbyqxmd.com/read/23031371/extramammary-paget-disease-immunohistochemistry-is-critical-to-distinguish-potential-mimickers
#11
Etienne Ce Wang, Yung Chien Kwah, Wee Ping Tan, Joyce Ss Lee, Suat Hoon Tan
Extra-mammary Paget disease (EMPD) is a rare intra-epithelial carcinoma that is usually found on the apocrine-rich skin of the perineum. We report 2 cases in which EMPD was initially misdiagnosed on the initial punch biopsy as melanoma-in-situ and Bowen disease respectively. Reasons for the misdiagnoses included a rare pigmented axillary variant of EMPD in the first case and atypical bowenoid features on H&E in the second. The cases are described with a critical review of the histopathological findings, along with a review of the current literature...
September 2012: Dermatology Online Journal
https://www.readbyqxmd.com/read/22949076/a-retrospective-analysis-of-real-life-practice-of-off-label-photodynamic-therapy-using-methyl-aminolevulinate-mal-pdt-in-20-italian-dermatology-departments-part-2-oncologic-and-infectious-indications
#12
Pier Giacomo Calzavara-Pinton, Maria Teresa Rossi, Raffaella Sala
Photodynamic therapy (PDT) with methyl aminolevulinate (MAL) has been suggested as a useful treatment option in a number of skin tumors, other than approved indications, and infections. However, evidence is poor because it is mainly supported by isolated case reports or small case series, often with conflicting results. To assess the effectiveness, tolerability and safety of off-label MAL-PDT in daily clinical practice in 20 Italian hospitals, a retrospective observational study of medical records of patients treated for off-label oncologic and infectious skin conditions was carried out...
January 2013: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/22796514/perianal-paget-s-disease-report-of-a-rare-case
#13
Maria Stavrou, Laura Martin, Faisal El-Madani, Veena Naik, Stephanos Papanastasiou, Sanjay Gupta
INTRODUCTION: Perianal extra-mammary Paget's disease is a rare skin disorder of unknown aetiology, which is frequently associated with malignancy. This case report draws attention to this rare condition and comments upon its diagnosis and treatment. PRESENTATION OF CASE: A 64-year-old otherwise fit man, presented to us in 2006 with one-year-long history of perianal irritation. On examination there was an erythematous discoid skin lesion in the right perianal area...
2012: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/22578344/-metastatic-extramammary-paget-s-disease-of-the-scrotum
#14
C Renaud-Vilmer, B Cavelier-Balloy, L Boazec, P Moguelet, M Bagot
BACKGROUND: Extra-mammary Paget's disease (EMPD) is currently considered a slowly progressing in situ adenocarcinoma. It is much more rarely associated with an invasive underlying adenocarcinoma than in mammary sites, where this association is almost always seen. However, an invasive course is to be feared where EMPD has been progressing for several years. PATIENTS AND METHODS: A 59-year-old man consulted for treatment of scrotal Paget's disease present for over 15 years and treated with topical emollients alone...
May 2012: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/21676258/effectiveness-of-photodynamic-therapy-for-mammary-and-extra-mammary-paget-s-disease-a-state-of-the-science-review
#15
REVIEW
Alexa A Nardelli, Tania Stafinski, Devidas Menon
BACKGROUND: Paget's disease is a rare skin disorder occurring in the breast (mammary) or in the groin, genital, peri-anal and axillary regions (extra-mammary). Typical treatment involves surgical excision, which in the case of extra-mammary Paget's disease, can lead to significant morbidity. Photodynamic therapy (PDT) which uses a topical or intravenous photosensitizing agent that is activated by a light source to ablate abnormal tissue, offers a minimally invasive alternative. The purpose of this study was to assess the effectiveness of photodynamic therapy in the treatment of Paget's disease...
June 15, 2011: BMC Dermatology
https://www.readbyqxmd.com/read/21501860/paget-s-disease-of-the-vulva-diagnosis-and-follow-up-key-to-management-a-retrospective-study-of-50-cases-from-queensland
#16
Ian S C Jones, Alex Crandon, Karen Sanday
OBJECTIVE: To review the clinical features, diagnosis, management, and outcomes for the 50 cases of Paget's disease (PD) of the vulva referred to Queensland Centre for Gynaecological Cancer between 1986 and 2009. METHODS: Vulvar PD cases from QCGC were reviewed and analyzed using the computer software Statistical Package for the Social Sciences (SPSS) 11.0. RESULTS: Paget's disease (PD) of the vulva is uncommon. Of the 50 patients, 2 have died of their PD, 1 patient that had coexisting PD died of squamous cell vulva cancer, and 11 died of unrelated causes...
July 2011: Gynecologic Oncology
https://www.readbyqxmd.com/read/21352263/cystic-fibrosis-transmembrane-conductance-regulator-is-helpful-in-the-distinction-of-extra-mammary-paget-s-disease-from-squamous-cell-carcinoma-in-situ-bowen-s-disease
#17
Rick Bains, Briana C Gleason, Antoinette B Thomas, Thomas A Victor, Thomas L Cibull
Cystic fibrosis transmembrane conductance regulator (CFTR) represents a cAMP-dependent channel found in normal apocrine glands. The classification and histogenesis of extra-mammary Paget's disease (EMPD) remains controversial, but it is generally accepted that primary EMPD exhibits apocrine differentiation. Therefore, we examined the utility of CFTR in the differential diagnosis of EMPD and squamous cell carcinoma in situ (SCCIS). Twenty-five cases of SCCIS and 14 cases of EMPD were evaluated for immunohistochemical expression of CFTR...
July 2011: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/20884199/extra-mammary-paget-s-disease-of-the-perianal-region-a-review-of-the-literature-emphasizing-the-operative-management-technique
#18
REVIEW
Ioannis D Kyriazanos, Nikolaos P Stamos, Lazaros Miliadis, Grigorios Noussis, Christos N Stoidis
The perianal skin is a common area for extra-mammary Paget's disease development. The unique clinical, histopathological, and immunohistochemical features which this medical phenomenon demonstrates, along with its rarity and frequent association with synchronous or metachronous carcinomas, present us with a treatment challenge. In order to organize the surgical treatment, it is important to determine whether the disease is localized exclusively to the perianal skin or associated with metastasis or anorectal carcinomas...
June 2011: Surgical Oncology
https://www.readbyqxmd.com/read/20803209/treatment-of-recurrent-vulvar-paget-disease-with-imiquimod-cream-a-case-report-and-review-of-the-literature
#19
REVIEW
Esra Tonguc, Tayfun Güngor, Turgut Var, Mustafa Ozat, Izzet Sahin, Levent Sirvan
INTRODUCTION: Extra-mammary Paget disease is one of the rare neoplastic conditions of the skin. The most common site of involvement is the vulva and presents itself with erythematous plaques. Surgery is the most important treatment option. In the recent years, there are publications of the topical use of imiquimod cream in extra-mammary cutaneous Paget disease. We report the case of a woman with recurrent vulvar Paget disease, who underwent successful treatment with imiquimod cream. We also review the reports of other patients with vulvar Paget disease who were treated with topical imiquimod cream...
January 2011: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/20184077/extra-mammary-paget-s-disease-of-the-scrotum-and-penis-a-case-report
#20
Y-M Chang, K-F Hsu, S-C Chang
Extra-mammary Paget's disease is a rare disease mainly observed in elderly patients. It is an intra-epithelial adenocarcinoma that involves the area rich in apocrine glands. The most common affected lesions are the vulva and perianal region, followed by the axillae and inguinoscrotal area. Mostly, extra-mammary Paget's disease is restricted to the epidermis, but advanced invasion to the dermis is possible with a poor prognosis of disease. The associated occult malignancy is reported and often exists for more than 10 years without clinical manifestation...
November 2009: Acta Chirurgica Belgica
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