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https://www.readbyqxmd.com/read/28415786/arterial-stiffness-and-blood-pressure-improvement-in-aldosterone-producing-adenoma-harboring-kcnj5-mutations-after-adrenalectomy
#1
Chia-Hui Chang, Ya-Hui Hu, Yao-Chou Tsai, Che-Hsiung Wu, Shuo-Meng Wang, Lian-Yu Lin, Yen-Hung Lin, Fumitoshi Satoh, Kwan-Dun Wu, Vin-Cent Wu
The aim of this study was to show the effect of KCNJ5 mutational status on arterial stiffness in aldosterone-producing adenomas after adrenalectomy. Between February 2008 and January 2010, we prospectively enrolled 108 aldosterone-producing adenoma patients undergoing adrenalectomy. We conducted repeated measurements of pulse wave velocity at baseline, 6 months, and 12 months after adrenalectomy, grouped by KCNJ5 mutational status. Prognostic factors of arterial stiffness and risk for hypertension at 12 months after adrenalectomy were analyzed after propensity score matching in a 1:1 ratio...
March 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28414694/ipsilesional-nystagmus-induced-by-vibration-in-subjects-with-m%C3%A3-ni%C3%A3-re-s-disease-or-vestibular-schwannoma
#2
María Fernanda Vargas Gamarra, Claudio Krstulovic, Vanesa Pérez Guillén, Herminio Pérez-Garrigues
OBJECTIVE: To analyze the frequency in which vibration-induced nystagmus (VIN) with ipsilesional direction appears in subjects with Ménière's disease (MD) or vestibular schwannoma (VS). STUDY DESIGN: Cross-sectional study. SETTING: Tertiary referral center. PATIENTS: Fifty-two subjects with MD and 21 subjects with vestibular schwannoma. INTERVENTION: Videonystagmographic recordings of VIN at 30, 60, and 100 Hz...
April 14, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28407138/calcium-and-bone-turnover-markers-in-acromegaly-a-prospective-controlled-study
#3
Tina Constantin, Vin Tangpricha, Reshma Shah, Nelson M Oyesiku, Octavian C Ioachimescu, James Ritchie, Adriana G Ioachimescu
Context: Acromegaly has been associated with calcium-phosphate and bone turnover alterations. Controlled studies of these interactions are sparse. Objective: To evaluate calcium and bone metabolism in active and treated acromegaly. Design/Setting/Patients: We conducted a controlled prospective study at a tertiary referral center. We studied 22 patients with acromegaly referred for surgical or medical therapy (ACM) and 22 with nonfunctioning pituitary adenomas referred for surgery (control)...
April 12, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28406186/renin-angiotensin-system-inhibitor-is-associated-with-lower-risk-of-ensuing-chronic-kidney-disease-after-functional-recovery-from-acute-kidney-injury
#4
Yu-Hsiang Chou, Tao-Min Huang, Szu-Yu Pan, Chin-Hao Chang, Chun-Fu Lai, Vin-Cent Wu, Ming-Shiou Wu, Kwan-Dun Wu, Tzong-Shinn Chu, Shuei-Liong Lin
Acute kidney injury (AKI) is an independent risk factor for ensuing chronic kidney disease (CKD). Animal studies have demonstrated that renin-angiotensin system (RAS) inhibitor can reduce ensuing CKD after functional recovery from AKI. Here we study the association between ensuing CKD and use of RAS inhibitor including angiotensin converting enzyme inhibitor or angiotensin II type 1a receptor blocker starting after renal functional recovery in our prospectively collected observational AKI cohort. Adult patients who had cardiac surgery-associated AKI (CSA-AKI) are studied...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28403943/plasma-metabolomics-in-adults-with-cystic-fibrosis-during-a-pulmonary-exacerbation-a-pilot-randomized-study-of-high-dose-vitamin-d3-administration
#5
RANDOMIZED CONTROLLED TRIAL
Jessica A Alvarez, Elizabeth Y Chong, Douglas I Walker, Joshua D Chandler, Ellen S Michalski, Ruth E Grossmann, Karan Uppal, Shuzhao Li, Jennifer K Frediani, Rabindra Tirouvanziam, ViLinh T Tran, Vin Tangpricha, Dean P Jones, Thomas R Ziegler
BACKGROUND: Cystic fibrosis (CF) is a chronic catabolic disease often requiring hospitalization for acute episodes of worsening pulmonary exacerbations. Limited data suggest that vitamin D may have beneficial clinical effects, but the impact of vitamin D on systemic metabolism in this setting is unknown. OBJECTIVE: We used high-resolution metabolomics (HRM) to assess the impact of baseline vitamin D status and high-dose vitamin D3 administration on systemic metabolism in adults with CF with an acute pulmonary exacerbation...
May 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28382814/sonographic-guide-for-botulinum-toxin-injections-of-the-lower-limb-euro-musculus-usprm-spasticity-approach
#6
Bayram Kaymak, Murat Kara, Fatih Tok, Ulaşlı Am, Öztürk Gt, Ke-Vin Chang, Ming-Yen Hsiao, Chen-Yu Hung, Arzu Y On, Levent Özçakar
The pertinent literature lacks overt technical data for optimal lower limb muscle botulinum toxin injections using ultrasound (US) imaging. Therefore, this guide is prepared for the commonly injected muscles of the lower limb and the pelvic girdle mainly in spasticity. It includes clinical information, anatomical description and explanation regarding the ultrasound imaging of several muscles. The figures have been organized to orient the readers on the innervation zones, injection sites, probe positionings and the US images simultaneously...
April 4, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28382597/earlier-versus-later-initiation-of-renal-replacement-therapy-among-critically-ill-patients-with-acute-kidney-injury-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#7
Tai-Shuan Lai, Chih-Chung Shiao, Jian-Jhong Wang, Chun-Te Huang, Pei-Chen Wu, Eric Chueh, Shih-Chieh Jeff Chueh, Kianoush Kashani, Vin-Cent Wu
BACKGROUND: Although the optimal timing of initiation of renal replacement therapy (RRT) in critically ill patients with acute kidney injury has been extensively studied in the past, it is still unclear. METHODS: In this systematic review, we searched all related randomized controlled trials (RCTs) that directly compared earlier and later RRT published prior to June 25, 2016, from PubMed, MEDLINE, and EMBASE. We extracted the study characteristics and outcomes of all-cause mortality, RRT dependence, and intensive care unit (ICU) and hospital length of stay (LOS)...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28373281/an-immunoaffinity-based-method-for-isolating-ultrapure-adult-astrocytes-based-on-atp1b2-targetting-by-the-acsa-2-antibody
#8
Mykhailo Y Batiuk, Filip de Vin, Sandra I Duqué, Chen Li, Takashi Saito, Takaomi Saido, Mark Fiers, T Grant Belgard, Matthew G Holt
Astrocytes are a major cell type in the mammalian central nervous system (CNS). Astrocytes are now known to play a number of essential roles in processes including synapse formation and function, as well as blood brain barrier formation and control of cerebral blood flow. However, our understanding of the molecular mechanisms underlying astrocyte development and function is still rudimentary (1). This lack of knowledge is at least partly due to the lack of tools currently available for astrocyte biology. ACSA-2 is a commercially available antibody originally developed for the isolation of astrocytes from young postnatal mouse brain, using magnetic cell sorting methods, but its utility in isolating cells from adult tissue has not yet been published...
April 3, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28362886/concomitant-primary-cns-lymphoma-and-fsh-pituitary-adenoma-arising-within-the-sella-entirely-coincidental
#9
Vin Shen Ban, Bedansh Roy Chaudhary, Kieren Allinson, Thomas Santarius, Ramez Wadie Kirollos
BACKGROUND AND IMPORTANCE: Collision tumors are the simultaneous occurrence of more than one type of neoplasm within an anatomic space. In the pituitary sella, collision tumors are exceedingly rare, and not much is known about their etiology and prognosis. CLINICAL PRESENTATION: A 74-year-old man presented with a concomitant primary pituitary lymphoma (diffuse large B-cell non-Hodgkin's lymphoma; DLBCL) and follicle-stimulating hormone (FSH)-adenoma diagnosed histologically after clinical features of apoplexy prompted urgent surgical decompression and resection...
January 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28351669/effect-of-maximum-inhalation-flow-and-inhaled-volume-on-formoterol-drug-deposition-in-vitro-from-an-easyhaler%C3%A2-dry-powder-inhaler
#10
Mohamad Abadelah, Firisteh Hazim, Henry Chrystyn, Golshan Bagherisadeghi, Hassan Rahmoune, Hassan Larhrib
Most patients using dry powder inhalers (DPIs) do not achieve the inhalation parameters recommended for pharmacopoeial in-vitro dose emission testing. The dose emission characteristics of formoterol from an Easyhaler have been measured using the Andersen Cascade Impactor (ACI) with a maximum inhalation flow (MIF) of 28.3, 60 and 90L/min and inhaled volumes (Vin) of 240, 750, 1500 and 2000mL. The total emitted dose (TED) was significantly higher at 90L/min (p<0.05), but the difference in the TED between low (28...
March 25, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28349703/comparative-effectiveness-of-botulinum-toxin-versus-non-surgical-treatments-for-treating-lateral-epicondylitis-a-systematic-review-and-meta-analysis
#11
Yu-Ching Lin, Wei-Ting Wu, Yu-Chun Hsu, Der-Sheng Han, Ke-Vin Chang
OBJECTIVES: To explore the effectiveness of botulinum toxin compared with non-surgical treatments in patients with lateral epicondylitis. METHODS: Data sources including PubMed, Scopus, Embase and Airity Library from the earliest record to February 2017 were searched. Study design, patients' characteristics, dosage/brand of botulinum toxin, injection techniques, and measurements of pain and hand grip strength were retrieved. The standardized mean differences (SMDs) in pain relief and grip strength reduction were calculated at the following time points: 2-4, 8-12, and 16 weeks or more after injection...
March 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28349030/treadmill-exercise-alleviates-nigrostriatal-dopaminergic-loss-of-neurons-and-fibers-in-rotenone-induced-parkinson-rats
#12
Mal-Soon Shin, Tae-Woon Kim, Jae-Min Lee, Eun-Sang Ji, Baek-Vin Lim
Parkinson disease is one of the common brain diseases caused by dopaminergic neuronal loss in the substantia nigra and dopaminergic fiber loss in the striatum. In the present study, the effects of treadmill exercise on motor performance, dopaminergic loss of neurons and fibers, and α-synuclein expression in the nigrostriatum were evaluated using rotenone-induced Parkinson rats. For the induction of Parkinson rats, 3-mg/kg rotenone was injected, once a day for 14 consecutive days. Treadmill running was conducted for 30 min once a day during 14 consecutive days...
February 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/28346307/ultrasound-guided-selective-cervical-root-injection-for-postherpetic-neuralgia
#13
Ke-Vin Chang, Chih-Peng Lin, Wei-Ting Wu, Levent Özçakar
No abstract text is available yet for this article.
March 24, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28341566/vibration-induced-nystagmus-in-patients-with-vestibular-schwannoma-characteristics-and-clinical-implications
#14
Jeon Mi Lee, Mi Joo Kim, Jin Won Kim, Dae Bo Shim, Jinna Kim, Sung Huhn Kim
OBJECTIVE: To investigate the clinical significance of vibration-induced nystagmus (VIN) in unilateral vestibular asymmetry and vestibular schwannoma. METHODS: Thirteen patients with vestibular schwannoma underwent the VIN test, in which stimulation was applied to the mastoid processes and sternocleidomastoid (SCM) muscles on the ipsilateral and contralateral sides of lesions. Preoperative VIN was measured, and changes in VIN were followed up for 6months after tumor removal...
March 6, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28339513/ultrasound-imaging-of-metastatic-colon-cancer-in-a-case-of-intractable-intercostal-neuralgia-scan-before-you-block
#15
Ke-Vin Chang, Wei-Ting Wu, Levent Özçakar
No abstract text is available yet for this article.
October 21, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28338668/corrigendum-long-term-outcome-of-aldosteronism-after-target-treatments
#16
Vin-Cent Wu, Shuo-Meng Wang, Chia-Hui Chang, Ya-Hui Hu, Lian-Yu Lin, Yen-Hung Lin, Shih-Chieh Jeff Chueh, Likwang Chen, Kwan-Dun Wu
No abstract text is available yet for this article.
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28321026/left-ventricular-outflow-tract-migration-of-a-balloon-expandable-prosthesis-during-transcatheter-aortic-valve-implantation
#17
Daisuke Hachinohe, Ken Kobayashi, Azusa Furugen, Ryuji Koshima
Valve migration into the left ventricular outflow tract (LVOT) during transcatheter aortic valve implantation (TAVI) is a life-threatening complication. An 89-year-old female patient was admitted for TAVI due to severe symptomatic aortic stenosis. After deployment of a balloon-expandable prosthesis, the prosthesis had migrated into the LVOT. The prosthesis was reimpacted to the aortic annulus by a balloon-assisted recapture procedure. Immediately after recapturing the prosthesis with an oversized balloon, the patient's vital signs deteriorated due to acute aortic regurgitation (AR), and a prompt valve-in-valve (V-in-V) procedure allowed us to stabilize the patient's condition...
March 17, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28285912/design-synthesis-and-potent-cytotoxic-activity-of-novel-7-n-substituted-sulfonyl-piperazinyl-methyl-camptothecin-derivatives
#18
Gao-Xiang Zhu, Pi-Le Cheng, Masuo Goto, Na Zhang, Susan L Morris-Natschke, Kan-Yen Hsieh, Guan-Zhou Yang, Qian-Ru Yang, Ying-Qian Liu, Hai-Le Chen, Xiao-Shuai Zhang, Kuo-Hsiung Lee
In an effort to discover potent camptothecin-derived antitumor agents, novel camptothecin analogues with sulfonylpiperazinyl motifs at position-7 were designed and synthesized. They were evaluated for in vitro cytotoxicity with the sulforhodamine-B (SRB) method in five types of human tumor cell lines, A-549, MDA-MB-231, KB, KB-VIN and MCF-7. With IC50 values in the low μM to nM level, most of the new analogues showed greater cytotoxicity activity than the reference compounds irinotecan and topotecan. Furthermore, compounds 12l (IC50, 1...
February 28, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28264546/sonographic-guide-for-botulinum-toxin-injections-of-the-upper-limb-euro-musculus-usprm-spasticity-approach
#19
Murat Kara, Bayram Kaymak, Alper M Ulaşli, Fatih Tok, Gokhan T Öztürk, Ke-Vin Chang, Ming-Yen Hsiao, Chen-Yu Hung, Arzu Yağiz On, Levent Özçakar
The pertinent literature lacks overt technical data for optimal upper limb muscle botulinum toxin injections using ultrasound (US) imaging. Therefore, this guide is prepared for the commonly injected muscles of the upper limb and the shoulder girdle mainly in spasticity. It includes clinical information, anatomical description and explanation regarding the US imaging of several muscles. The figures have been organized to orient the readers on the innervation zones, injection sites, probe positionings and the US images simultaneously...
March 6, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28263111/survey-of-attitudes-toward-and-experiences-with-animal-abuse-encounters-in-a-convenience-sample-of-us-veterinarians
#20
Lori R Kogan, Regina M Schoenfeld-Tacher, Peter W Hellyer, Mark Rishniw, Rebecca A Ruch-Gallie
OBJECTIVE To survey practicing veterinarians regarding their perceptions of and experiences with cases of suspected or confirmed animal abuse and related state laws. DESIGN Cross-sectional study. POPULATION Members of the Veterinary Information Network (VIN; n = 34,144) who were in veterinary practice at the time of the survey. PROCEDURES A survey was designed and distributed online to all VIN members from January 26 to February 28, 2015. Responses were compiled, and binary logistic regression analysis was performed to identify factors that influenced decisions or perceptions regarding animal abuse encounters and related legislation...
March 15, 2017: Journal of the American Veterinary Medical Association
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