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https://www.readbyqxmd.com/read/29045916/suicide-deaths-among-patients-with-end-stage-renal-disease-receiving-dialysis-a-population-based-retrospective-cohort-study-of-64-000-patients-in-taiwan
#1
I-Ming Chen, Po-Hsien Lin, Vin-Cent Wu, Chi-Shin Wu, Jia-Chi Shan, Shu-Sen Chang, Shih-Cheng Liao
BACKGROUND: Patients with end-stage renal disease (ESRD) who receive dialysis may experience increased distress and risk of suicide. METHODS: This population-based retrospective cohort study linked Taiwan's national register of ESRD patients on dialysis and the cause-of-death mortality data file. A separate multiple-cause-of-death data file was used to investigate the detailed suicide methods used. Standardized mortality ratios (SMRs) were calculated for the overall patient group and by sex, age, year of initiating dialysis, method of suicide, and time since initiation of dialysis...
October 9, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29043863/preparation-and-evaluation-of-vinpocetine-self-emulsifying-ph-gradient-release-pellets
#2
Mengqi Liu, Shiming Zhang, Shuxia Cui, Fen Chen, Lianqun Jia, Shu Wang, Xiumei Gai, Pingfei Li, Feifei Yang, Weisan Pan, Xinggang Yang
The main objective of this study was to develop a pH gradient release pellet with self-emulsifying drug delivery system (SEDDS), which could not only improve the oral bioavailability of Vinpocetine (VIN), a poor soluble drug, but reduce the fluctuation of plasma concentration. First, the liquid VIN SEDDS formulation was prepared. Then the self-emulsifying pH gradient release pellets were prepared by extrusion spheronization technique, and formulation consisted by the liquid SEDDS, absorbent (colloidal silicon dioxide), penetration enhancer (sodium chloride), microcrystalline cellulose, ethyl alcohol, and three coating materials (HPMC, Eudragit L30D55, Eudragit FS30D) were eventually selected...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/29037045/bi4o4cu1-7se2-7cl0-3-an-intergrowth-of-biocuse-and-bi2o2se-stabilized-by-the-addition-of-a-third-anion
#3
Quinn D Gibson, Matthew S Dyer, George F S Whitehead, Jonathan Alaria, Michael J Pitcher, Holly J Edwards, John B Claridge, Marco Zanella, Karl Dawson, Troy D Manning, Vin R Dhanak, Matthew J Rosseinsky
Layered two-anion compounds are of interest for their diverse electronic properties. The modular nature of their layered structures offers opportunities for the construction of complex stackings used to introduce or tune functionality, but the accessible layer combinations are limited by the crystal chemistries of the available anions. We present a layered three-anion material, Bi4O4Cu1.7Se2.7Cl0.3, which adopts a new structure type composed of alternately stacked BiOCuSe and Bi2O2Se-like units. This structure is accessed by inclusion of three chemically distinct anions, which are accommodated by aliovalently substituted Bi2O2Se0...
October 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29035398/risks-factors-and-timing-of-genital-human-papillomavirus-hpv-infection-in-female-stem-cell-transplant-survivors-a-longitudinal-study
#4
D Shanis, P Anandi, C Grant, A Bachi, N Vyas, M A Merideth, P A Pophali, E Koklanaris, S Ito, B N Savani, A J Barrett, M Battiwalla, P Stratton
This longitudinal single-center study describes the timing and risk factors for genital human papillomavirus (HPV) disease in women after allogeneic hematopoietic cell transplantation (HCT). Between 1994 and 2014, 109 females underwent HCT of whom 82 surviving transplant for >1 year had regular, comprehensive genital tract assessment and treatment of HPV disease. The cumulative proportions of any genital HPV infection at 1, 3, 5, 10 and 20 years were 4.8%, 14.9%, 28.1%, 36.7% and 40.9%, respectively. Demographic, disease-related factors, chronic GvHD (cGvHD) and its treatment were analyzed for their association with persistent, multifocal or severe genital HPV disease...
October 16, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29026332/ultrasound-guided-methotrexate-injection-for-de-quervain-disease-of-the-wrist-what-lies-beyond-the-horizon
#5
Abdallah El-Sayed Allam, Doaa Shawky Al-Ashkar, Ahmed A Negm, Basma Aly Eltawab, Wei-Ting Wu, Ke-Vin Chang
De Quervain disease (DQVD) is one of the most common causes of lateral wrist pain and can lead to significant disability. The current case involves a right-handed, middle-aged, female patient with severe lateral wrist pain due to DQVD. Her pain was not responsive to oral non-steroidal anti-inflammatory drugs, rehabilitation, and repeated corticosteroid injections. Because she refused surgical intervention, we performed ultrasound-guided methotrexate injections (four times). After the injections, dramatic pain relief, functional improvement, and reduction of the thickness of the retinaculum and tendons in the first dorsal extensor compartment of the wrist were noted...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29021705/global-analysis-of-ginsenoside-rg1-protective-effects-in-%C3%AE-amyloid-treated-neuronal-cells
#6
Ji Seon Shim, Min-Young Song, Sung-Vin Yim, Seung-Eun Lee, Kang-Sik Park
BACKGROUND: A number of reports have described the protective effects of ginsenoside Rg1 (Rg1) in Alzheimer's disease (AD). However, the protective mechanisms of Rg1 in AD remain elusive. METHODS: To investigate the potential mechanisms of Rg1 in β-amyloid peptide-treated SH-SY5Y cells, a comparative proteomic analysis was performed using stable isotope labeling with amino acids in cell culture combined with nano-LC-MS/MS. RESULTS: We identified a total of 1,149 proteins in three independent experiments...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28994661/vitamin-d-supplementation-decreases-immune-activation-and-exhaustion-in-hiv-1-infected-youth
#7
Allison Ross Eckard, Mary Ann O'Riordan, Julia C Rosebush, Seungeun Thera Lee, Jakob G Habib, Joshua H Ruff, Danielle Labbato, Julie E Daniels, Monika Uribe-Leitz, Vin Tangpricha, Ann Chahroudi, Grace A McComsey
BACKGROUND: Heightened immune activation and exhaustion drive HIV disease progression and co-morbidities. Vitamin D has pleiotropic immunomodulatory effects, but little is known about the effects of supplementation in HIV. Our study investigates changes in immune activation and exhaustion markers after 12 months of supplementation in virologically-suppressed HIV-infected youth with vitamin D insufficiency. METHODS: This is a randomized, active-control, double-blind trial investigating with 3 different vitamin D3 doses [18,000 (standard/active-control dose), 60,000 (moderate dose) and 120,000 IU/monthly (high dose)] in 8-26 year old HIV-infected youth on combination antiretroviral therapy with baseline serum 25-hydroxyvitamin D (25(OH)D) concentrations ≤30 ng/mL...
October 10, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28956362/ctnnb1-mutation-in-aldosterone-producing-adenoma
#8
REVIEW
Jian Jhong Wang, Kang Yung Peng, Vin Cent Wu, Fen Yu Tseng, Kwan Dun Wu
Discoveries of somatic mutations permit the recognition of subtypes of aldosterone-producing adenomas (APAs) with distinct clinical presentations and pathological features. Catenin β1 (CTNNB1) mutation in APAs has been recently described and discussed in the literature. However, significant knowledge gaps still remain regarding the prevalence, clinical characteristics, pathophysiology, and outcomes in APA patients harboring CTNNB1 mutations. Aberrant activation of the Wnt/β-catenin signaling pathway will further modulate tumorigenesis...
September 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28945902/endocrine-treatment-of-gender-dysphoric-gender-incongruent-persons-an-endocrine-society-clinical-practice-guideline
#9
Wylie C Hembree, Peggy T Cohen-Kettenis, Louis Gooren, Sabine E Hannema, Walter J Meyer, M Hassan Murad, Stephen M Rosenthal, Joshua D Safer, Vin Tangpricha, Guy G T'Sjoen
Objective: To update the "Endocrine Treatment of Transsexual Persons: An Endocrine Society Clinical Practice Guideline," published by the Endocrine Society in 2009. Participants: The participants include an Endocrine Society-appointed task force of nine experts, a methodologist, and a medical writer. Evidence: This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation approach to describe the strength of recommendations and the quality of evidence...
September 13, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28939374/factors-associated-with-early-outcomes-following-standardised-therapy-in-children-with-ulcerative-colitis-protect-a-multicentre-inception-cohort-study
#10
Jeffrey S Hyams, Sonia Davis, David R Mack, Brendan Boyle, Anne M Griffiths, Neal S LeLeiko, Cary G Sauer, David J Keljo, James Markowitz, Susan S Baker, Joel Rosh, Robert N Baldassano, Ashish Patel, Marian Pfefferkorn, Anthony Otley, Melvin Heyman, Joshua Noe, Maria Oliva-Hemker, Paul Rufo, Jennifer Strople, David Ziring, Stephen L Guthery, Boris Sudel, Keith Benkov, Prateek Wali, Dedrick Moulton, Jonathan Evans, Michael D Kappelman, Alison Marquis, Francisco A Sylvester, Margaret H Collins, Suresh Venkateswaran, Marla Dubinsky, Vin Tangpricha, Krista L Spada, Ashley Britt, Bradley Saul, Nathan Gotman, Jessie Wang, Jose Serrano, Subra Kugathasan, Thomas Walters, Lee A Denson
BACKGROUND: Previous retrospective studies of paediatric ulcerative colitis have had limited ability to describe disease progression and identify predictors of treatment response. In this study, we aimed to identify characteristics associated with outcomes following standardised therapy after initial diagnosis. METHODS: The PROTECT multicentre inception cohort study was based at 29 centres in the USA and Canada and included paediatric patients aged 4-17 years who were newly diagnosed with ulcerative colitis...
September 19, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28927790/design-semisynthesis-and-potent-cytotoxic-activity-of-novel-10-fluorocamptothecin-derivatives
#11
Cheng-Jie Yang, Zi-Long Song, Masuo Goto, Pei-Ling Hsu, Xiao-Shuai Zhang, Qian-Ru Yang, Ying-Qian Liu, Mei-Juan Wang, Susan L Morris-Natschke, Xiao-Fei Shang, Kuo-Hsiung Lee
Fluorination is a well-known strategy for improving the bioavailability of bioactive molecules in the lead optimization phase of drug discovery projects. In an attempt to improve the antitumor activity of camptothecins (CPTs), novel 10-fluoro-CPT derivatives were designed, synthesized and evaluated for cytotoxicity against five human cancer cell lines (A-549, MDA-MB-231, KB, KB-VIN and MCF-7). All of the derivatives showed more potent in vitro cytotoxic activity than the clinical CPT-derived drug irinotecan against the tumor cell lines tested, and most of them showed comparable or superior potency to topotecan...
September 8, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28911163/response-to-letter-calcium-and-bone-turnover-markers-in-acromegaly-a-prospective-controlled-study
#12
Tina Constantin, Vin Tangpricha, Reshma Shah, Nelson M Oyesiku, Octavian Ioachimescu, James Ritchie, Adriana G Ioachimescu
No abstract text is available yet for this article.
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28902705/effects-of-vitamin-d-supplementation-on-bone-mineral-density-and-bone-markers-in-hiv-infected-youth
#13
Allison Ross Eckard, Mary Ann O'Riordan, Julia C Rosebush, Joshua H Ruff, Ann Chahroudi, Danielle Labbato, Julie E Daniels, Monika Uribe-Leitz, Vin Tangpricha, Grace A McComsey
BACKGROUND: Low bone mineral density (BMD) is a significant co-morbidity in HIV. However, studies evaluating vitamin D supplementation on bone health in this population are limited. This study investigates changes in bone health parameters after 12 months of supplementation in HIV-infected youth with vitamin D insufficiency. METHODS: This is a randomized, active-control, double-blind trial investigating changes in bone parameters with 3 different vitamin D3 doses [18,000 (standard/control dose), 60,000 (moderate dose) and 120,000 IU/monthly (high dose)] in HIV-infected youth 8-25 years old with baseline serum 25-hydroxyvitamin D (25(OH)D) concentrations <30 ng/mL...
September 11, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28902663/aldosterone-induces-left-ventricular-subclinical-systolic-dysfunction-a-strain-imaging-study
#14
Zheng-Wei Chen, Kuan-Chih Huang, Jen-Kuang Lee, Lung-Chun Lin, Ching-Way Chen, Yi-Yao Chang, Che-Wei Liao, Vin-Cent Wu, Chi-Shen Hung, Yen-Hung Lin
BACKGROUND: Primary aldosteronism is associated with a higher incidence of left ventricular (LV) hypertrophy and diastolic dysfunction than essential hypertension. However, systolic function via endocardial measurements is similar between patients with primary aldosteronism and essential hypertension. Speckle-tracking echocardiography is a sensitive tool which can detect subclinical impairments in systolic function. The aim of this study was to investigate aldosterone-induced subclinical impairments in systolic function...
September 11, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28892632/gan-metalens-for-pixel-level-full-color-routing-at-visible-light
#15
Bo Han Chen, Pin Chieh Wu, Vin-Cent Su, Yi-Chieh Lai, Cheng Hung Chu, I Chen Lee, Jia-Wern Chen, Yu Han Chen, Yung-Chiang Lan, Chieh-Hsiung Kuan, Din Ping Tsai
Metasurface-based components are known to be one of the promising candidates for developing flat optical systems. However, their low working efficiency highly limits the use of such flat components for feasible applications. Although the introduction of the metallic mirror has been demonstrated to successfully enhance the efficiency, it is still somehow limited for imaging and sensing applications because they are only available for devices operating in a reflection fashion. Here, we demonstrate three individual GaN-based metalenses working in a transmission window with extremely high operation efficiency at visible light (87%, 91...
October 11, 2017: Nano Letters
https://www.readbyqxmd.com/read/28891732/effects-of-vitamin-d-supplementation-on-carotid-intima-media-thickness-in-hiv-infected-youth
#16
Allison Ross Eckard, Paolo Raggi, Mary Ann O'Riordan, Julia C Rosebush, Danielle Labbato, Ann Chahroudi, Joshua H Ruff, Christopher T Longenecker, Vin Tangpricha, Grace A McComsey
No abstract text is available yet for this article.
September 11, 2017: Virulence
https://www.readbyqxmd.com/read/28888384/ulnar-nerve-cross-sectional-area-for-the-diagnosis-of-cubital-tunnel-syndrome-a-meta-analysis-of-ultrasonographic-measurements
#17
REVIEW
Ke-Vin Chang, Wei-Ting Wu, Der-Sheng Han, Levent Özçakar
OBJECTIVE: This meta-analysis aimed to examine the performance of sonographic cross-sectional area (CSA) measurements, in the diagnosis of cubital tunnel syndrome (CuTS). DATA SOURCE: Electronic databases, comprising of PubMed and Embase, were searched for the pertinent literature before July 2017. STUDY SELECTION: Fourteen trials comparing the ulnar nerve CSA measurements between participants, with and without CuTS, were included. DATA EXTRACTION: Study design, participants' demographics, diagnostic reference of CuTS and methods of CSA measurement...
September 6, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28887161/loss-of-discoidin-domain-receptor-1-ddr1-via-cpg-methylation-during-emt-in-epithelial-ovarian-cancer
#18
Vin Yee Chung, Tuan Zea Tan, Rui-Lan Huang, Hung-Cheng Lai, Ruby Yun-Ju Huang
Epithelial ovarian cancer (EOC) can be stratified according to the stages of epithelial-mesenchymal transition (EMT). Here, we aim to identify tyrosine kinases (TKs) in EOC that correlate with the EMT subtypes. By gene expression microarray, we analyzed the expression levels of tyrosine kinases in EOC cell lines in correlation with EMT. Among the candidate TKs identified, DDR1 was expressed mainly in EOC cells with an Epithelial phenotype. Its expression was validated by qPCR, ELISA and western blotting. Using Infinium HumanMethylation27K BeadChip array and pyrosequencing, we further analyzed the CpG methylation levels at the DDR1 promoter in EOC cells and found that the CpG methylation levels of DDR1 promoter correlated negatively with the expression of DDR1 along the EMT spectrum...
November 30, 2017: Gene
https://www.readbyqxmd.com/read/28874727/effectiveness-of-glenohumeral-joint-dilatation-for-treatment-of-frozen-shoulder-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#19
Wei-Ting Wu, Ke-Vin Chang, Der-Sheng Han, Chung-Hsun Chang, Fu-Sui Yang, Chih-Peng Lin
The objective was to explore the effectiveness of glenohumeral joint distension for the treatment of frozen shoulder. We searched electronic data sources including PubMed, Scopus, and Embase from the earliest records available to February 2017. Eleven randomized controlled trials including at least one pair of comparisons between capsular distension and a reference treatment were included, comprising 747 participants. Patients' characteristics, details of reference treatments, aspects of capsular distension therapy, and outcome measurement were evaluated at three points in time: baseline, early following intervention, and at the trial's end...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28832680/predicting-the-length-of-hospital-stay-of-post-acute-care-patients-in-taiwan-using-the-chinese-version-of-the-continuity-assessment-record-and-evaluation-item-set
#20
Chen-Yu Hung, Wei-Ting Wu, Ke-Vin Chang, Tyng-Guey Wang, Der-Sheng Han
BACKGROUND: The Chinese version of the Continuity Assessment Record and Evaluation (CARE-C) item set was developed to facilitate the assessment of post-acute care (PAC) patients in Taiwan. Considering that the length of hospital stay (LOS) has a significant effect on the total healthcare cost, determining whether the CARE-C scores could predict the LOS of PAC patients is of great interest to the PAC providers. METHODS: This prospective trial included PAC patients with stroke or central nervous system injuries...
2017: PloS One
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