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https://www.readbyqxmd.com/read/29655877/endocrine-and-haemodynamic-changes-in-resistant-hypertension-and-blood-pressure-responses-to-spironolactone-or-amiloride-the-pathway-2-mechanisms-substudies
#1
Bryan Williams, Thomas M MacDonald, Steve V Morant, David J Webb, Peter Sever, Gordon T McInnes, Ian Ford, J Kennedy Cruickshank, Mark J Caulfield, Sandosh Padmanabhan, Isla S Mackenzie, Jackie Salsbury, Morris J Brown
BACKGROUND: In the PATHWAY-2 study of resistant hypertension, spironolactone reduced blood pressure substantially more than conventional antihypertensive drugs. We did three substudies to assess the mechanisms underlying this superiority and the pathogenesis of resistant hypertension. METHODS: PATHWAY-2 was a randomised, double-blind crossover trial done at 14 UK primary and secondary care sites in 314 patients with resistant hypertension. Patients were given 12 weeks of once daily treatment with each of placebo, spironolactone 25-50 mg, bisoprolol 5-10 mg, and doxazosin 4-8 mg and the change in home systolic blood pressure was assessed as the primary outcome...
April 11, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29614895/heart-rate-reducing-therapy-with-add-on-ivabradine-and-bisoprolol-before-coronary-computed-tomographic-angiography-in-a-fast-track-ambulatory-setting
#2
Viktoria Muster, Markus Wallner, Albrecht Schmidt, Martin Kapl, Friederike von Lewinski, Peter Rainer, Pia Reittner, Manfred Tillich, Peter Brader, Dieter Hm Szolar, Dirk von Lewinski
Objective This study was performed to determine whether add-on oral ivabradine in patients treated with beta blockers 1 hour before coronary computed tomographic angiography (CCTA) is effective in lowering the heart rate and thus improving CCTA quality. Methods In this single-center cohort study, the data of 294 patients referred for ambulant CCTA were retrospectively screened. Patients with an initial heart rate of ≥75 bpm (n = 112) were pretreated with either a combination of bisoprolol and ivabradine or with bisoprolol alone...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29602642/persistent-tachycardia-in-clozapine-treated-patients-a-24-hour-ambulatory-electrocardiogram-study
#3
Björn M Nilsson, Leif Lindström, Issam Mohsen, Karolina Holmlöv, Robert Bodén
Tachycardia is associated with cardiovascular mortality. Tachycardia is also a known clozapine adverse effect. However, whether clozapine-associated tachycardia is persistent is not known. Thirty clozapine-treated patients with clinical tachycardia were investigated with 24-hour ambulatory electrocardiography (ECG). Baseline peripheral heart rate (HR) was 106.7±7.8. The ambulatory ECG 24-hour-HR was 98.7±9.7. Baseline HR and 24-hour-HR correlated strongly (r=0.74, p=0.000003). Daytime HR was 106.4±9.9 and nighttime HR 89...
March 27, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29601411/antihypertensive-drug-use-in-resistant-and-nonresistant-hypertension-and-in-controlled-and-uncontrolled-resistant-hypertension
#4
Alejandro de la Sierra, Pedro Armario, Anna Oliveras, José R Banegas, Manuel Gorostidi, Ernest Vinyoles, Juan J de la Cruz, Julián Segura, Luis M Ruilope
BACKGROUND AND AIM: Treatment-resistant hypertension (TRH) is associated with particular clinical features, nonadherence, and suboptimal treatment. We assessed possible associations of antihypertensive drug classes, specific agents inside each class, and types of combinations, with the presence of non-TRH vs. TRH, and with controlled vs. uncontrolled TRH. METHODS: Comparisons were done in 14 264 patients treated with three drugs (non-TRH: 2988; TRH: 11 276) and in 6974 treated with at least four drugs (controlled TRH: 1383; uncontrolled TRH: 5591)...
March 29, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29562910/left-ventricular-hypertrophy-diagnosed-after-a-stroke-a-case-report
#5
Wilfred Ifeanyi Umeojiako, Ritesh Kanyal
BACKGROUND: Stroke is a recognized clinical course of hypertrophic cardiomyopathy. This interesting case showed notable difference on the electrocardiogram of a patient 4 months prior to suffering a stroke and 10 days after suffering a stroke. The pre-stroke electrocardiogram showed atrial fibrillation with a narrow QRS complex, while the post-stroke electrocardiogram showed marked left ventricular hypertrophy. Left ventricular hypertrophy was diagnosed using the Sokolow-Lyon indices...
March 22, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29557206/occurrence-of-composite-cardiac-endpoints-with-change-in-resting-heart-rate-among-chinese-patients-with-coronary-artery-disease-chinese-cohort-from-the-real-world-biso-cad-study
#6
Yundai Chen, Xinchun Yang, Shi'an Huang, Guosheng Fu, Xiaoping Chen, Yu Yang, Shaowen Liu, Haiyan Xu, Tianrong Ma, Xuchen Zhou, Zhan Lv, Ming Yang, Xuedong Gan, Dong Xu, Feng Cao, Huiliang Liu, Junxia Li, Qiangsun Zheng, Ningfu Wang, Yong Yuan, Wenxian Liu, Tianlun Yang
OBJECTIVE: We evaluated change in resting heart rate (RHR) and its impact on the prognosis in Chinese coronary artery disease (CAD) patients treated with bisoprolol and also assessed the drug safety and tolerability. METHODS: This phase IV, single arm observational study was a sub-study of the BISO-CAD study conducted across 20 hospitals in China, between October 2011 to July 2015 with follow-up at 6, 12 and 18 months after baseline. The primary endpoint was occurrence of composite cardiac events...
March 20, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29545006/risk-of-all-cause-mortality-in-diabetic-patients-taking-%C3%AE-blockers
#7
Tetsuro Tsujimoto, Hiroshi Kajio, Martin F Shapiro, Takehiro Sugiyama
OBJECTIVE: To assess the relationship between use of β-blockers and all-cause mortality in patients with and without diabetes. PATIENTS AND METHODS: Using data from the US National Health and Nutrition Examination Survey 1999-2010, we conducted a prospective cohort study. The study participants were followed-up from the survey participation date until December 31, 2011. We used a Cox proportional hazards model for all-cause mortality analysis. The multivariate-adjusted hazard ratios (HRs) of the participants taking β-blockers were compared with those of the participants not taking β-blockers...
March 9, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29544975/-pharmacokinetic-risk-factors-of-beta-blockers-overdose-in-the-elderly-case-report-and-pharmacology-approach
#8
L Lafarge, L Bourguignon, N Bernard, T Vial, M-J Dehan-Moya, B De La Gastine, S Goutelle
Beta-blockers are widely prescribed in elderly patients and may induce severe adverse drug reactions. We report a case of bisoprolol-induced bradycardia in an elderly patient with impaired renal function and use of cytochrome P450 inhibitors. A literature review has been performed in order to analyze pharmacokinetic risk factors of beta-blockers overdosing in geriatrics. Various mechanisms can result in decreased elimination of beta-blockers. These mechanisms vary according to the beta-blocker agent and may be combined in some individuals, especially elderly patients...
March 12, 2018: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29519953/-%C3%AE-blocker-dialyzability-in-maintenance-hemodialysis-patients-a-randomized-clinical-trial
#9
Alvin Tieu, Thomas J Velenosi, Andrew S Kucey, Matthew A Weir, Bradley L Urquhart
BACKGROUND AND OBJECTIVES: There is a paucity of data available to describe drug dialyzability. Of the available information, most was obtained before implementation of modern hemodialysis membranes. Our study characterized dialyzability of the most commonly prescribed β -blockers in patients undergoing high-flux hemodialysis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Patients on hemodialysis ( n =8) were recruited to an open label, pharmacokinetic, four-way crossover trial...
March 8, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29500811/efficacy-of-propranolol-bisoprolol-and-pyridostigmine-for-postural-tachycardia-syndrome-a-randomized-clinical-trial
#10
Jangsup Moon, Do-Yong Kim, Woo-Jin Lee, Han Sang Lee, Jung-Ah Lim, Tae-Joon Kim, Jin-Sun Jun, Byeongsu Park, Jung-Ick Byun, Jun-Sang Sunwoo, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Ki-Young Jung, Manho Kim, Sang Kun Lee, Kon Chu
Postural tachycardia syndrome (POTS) is a form of dysautonomia which presents with complex symptoms including orthostatic intolerance. Several medications are prescribed for POTS; however, the efficacy of sustained medical treatment has not been well-investigated. Here, we conducted a 2 × 2 factorial design, randomized, clinical trial of a 3-month medical treatment regimen in POTS patients. Patients were randomly allocated to 4 treatment groups (Group 1: propranolol; Group 2: bisoprolol; Group 3: propranolol + pyridostigmine; Group 4: bisoprolol + pyridostigmine)...
March 2, 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29464917/head-to-head-comparison-of-the-heart-rate-variability-between-the-bisoprolol-transdermal-patch-and-bisoprolol-fumarate-tablet
#11
Akinori Sairaku, Yukiko Nakano, Nobuo Shiode, Kazuyoshi Suenari, Nozomu Oda, Koichi Ono, Yasuki Kihara
AIM: The bisoprolol transdermal patch is a newly developed β-blocker designed to deliver its pharmaceutical ingredient through the skin surface. We aimed to compare the bisoprolol transdermal patch and bisoprolol fumarate tablet using the heart rate variability (HRV). METHOD: Eligible hypertensive patients received a 2-week administration with a 2.5 mg bisoprolol fumarate tablet, followed by 24-hour Holter monitoring. The tablet was then switched to a 4 mg bisoprolol transdermal patch, and after 2-weeks of its administration, the Holter monitoring was repeated...
February 21, 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29433578/resistant-hypertension-on-treatment-reshypot-sequential-nephron-blockade-compared-to-dual-blockade-of-the-renin-angiotensin-aldosterone-system-plus-bisoprolol-in-the-treatment-of-resistant-arterial-hypertension-study-protocol-for-a-randomized-controlled-trial
#12
Elizabeth do Espirito Santo Cestário, Letícia Aparecida Barufi Fernandes, Luiz Tadeu Giollo-Júnior, Jéssica Rodrigues Roma Uyemura, Camila Suemi Sato Matarucco, Manoel Idelfonso Paz Landim, Luciana Neves Cosenso-Martin, Lúcia Helena Bonalume Tácito, Heitor Moreno, José Fernando Vilela-Martin, Juan Carlos Yugar-Toledo
BACKGROUND: Resistant hypertension is characterized when the blood pressure (BP) remains above the recommended goal after taking three antihypertensive drugs with synergistic actions at their maximum recommended tolerated doses, preferably including a diuretic. Identifying the contribution of intravascular volume and serum renin in maintaining BP levels could help tailor more effective hypertension treatment, whether acting on the control of intravascular volume or sodium balance, or acting on the effects of the renin-angiotensin-aldosterone system (RAAS) on the kidney...
February 12, 2018: Trials
https://www.readbyqxmd.com/read/29391388/a-patient-with-left-bundle-branch-block-and-persistent-atrial-fibrillation-treated-with-cardiac-catheter-ablation-and-pharmacologic-cardiac-resynchronization-therapy-without-the-use-of-an-implantable-cardiac-device
#13
Hideyuki Hasebe
BACKGROUND Left bundle branch block (LBBB) is associated with atrial fibrillation (AF) and systolic heart failure, which can be treated with cardiac resynchronization therapy (CRT) that includes an implantable cardiac device (ICD). However, in some patients, LBBB may vary with heart rate, and during episodes of AF in LBBB, aberrant ventricular conduction, or wide QRS complex tachycardia (Ashman beats) can occur. This report is a case of LBBB treated with pharmacologic CRT, without the use of an ICD. CASE REPORT A 68-year-old man presented with persistent AF and systolic heart failure...
February 2, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29366925/pharmacological-intervention-in-hypertension-using-beta-blockers-real-world-evidence-for-long-term-effectiveness
#14
Meritxell Sabidó, Thilo Hohenberger, Guido Grassi
The study objective was to compare the long-term incidence and risk of mortality and cardiovascular outcomes in patients with hypertension initiating bisoprolol, other β-blockers or other antihypertensive therapies. Cohort analysis using UK Clinical Practice Research Datalink (CPRD). Adult patients with first diagnosis of hypertension recorded between 2000 and 2014, with ≥365 days of registration to first event and initiating monotherapies of bisoprolol, other β-blockers or drugs other than β-blockers within 6 months of diagnosis were included...
January 31, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29361520/divergent-effect-of-adrenaline-in-human-induced-pluripotent-stem-cell-derived-cardiomyocytes-obtained-from-hypertrophic-cardiomyopathy
#15
Chandra Prajapati, Marisa Ojala, Katriina Aalto-Setälä
Hypertrophic cardiomyopathy (HCM) is a common inherited cardiac disease that affects the heart muscle with diverse clinical outcomes. HCM can cause sudden cardiac death (SCD) during or immediately after mild to rigorous physical work in young patients. However, the mechanism causing SCD as a result of exercise remains unknown, but exercise-induced ventricular arrhythmias are thought to be responsible for this fatal consequence. To understand the disease mechanism behind HCM in a better way, we generated patient-specific induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) from HCM patients carrying either the MYBPC3-Gln1061X or TPM1-Asp175Asn mutation...
January 3, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29338932/functional-characteristics-of-a-renal-h-lipophilic-cation-antiport-system-in-porcine-llc-pk-1-cells-and-rats
#16
Ryutaro Matsui, Ryutaro Hattori, Youhei Usami, Masumi Koyama, Yuki Hirayama, Emi Matsuba, Yukiya Hashimoto
We have recently found an H+ /quinidine (a lipophilic cation, QND) antiport system in Madin-Darby canine kidney (MDCK) cells. The primary aim of the present study was to evaluate whether the H+ /lipophilic cation antiport system is expressed in porcine LLC-PK1 cells. That is, we investigated uptake and/or efflux of QND and another cation, bisoprolol, in LLC-PK1 cells. In addition, we studied the renal clearance of bisoprolol in rats. Uptake of QND into LLC-PK1 cells was decreased by acidification of the extracellular pH or alkalization of the intracellular pH...
February 2018: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29276907/-regulatory-adaptive-status-in-determining-the-effectiveness-of-bisoprololum-and-sotalolum-in-patients-with-hypertensive-disease-and-paroxysmal-supraventricular-tachycardia
#17
V G Tregubov, V M Pokrovsky, N M Nazhalkina
AIM: To determine efficacy of bisoprolol and sotalol treatments in patients with paroxysmal supraventricular tachycardia (SVT) and essential hypertension (EH) considering effects of these treatments on the regulatory adaptive status (RAS). MATERIALS AND METHODS: The study included 49 patients with paroxysmal SVT associated with stage II-III EH randomized to two groups of either bisoprolol (6.9±2.2 mg/day, n=25) or sotalol (162.5±46.2 mg/day, n=24) treatment. Lisinopril (14...
2017: Kardiologiia
https://www.readbyqxmd.com/read/29159953/relationship-between-heart-failure-concurrent-chronic-obstructive-pulmonary-disease-and-beta-blocker-use-a-danish-nationwide-cohort-study
#18
Maurizio Sessa, Annamaria Mascolo, Rikke Nørmark Mortensen, Mikkel Porsborg Andersen, Giuseppe Massimo Claudio Rosano, Annalisa Capuano, Francesco Rossi, Gunnar Gislason, Henrik Enghusen-Poulsen, Christian Torp-Pedersen
AIMS: To compare the hazard of all-cause, chronic obstructive pulmonary disease (COPD) and heart failure (HF) hospitalization in carvedilol vs. metoprolol/bisoprolol/nebivolol users with COPD and concurrent HF from 2009 to 2012, and to evaluate the use and persistence in treatment of these β-blockers, their impact on the risk of COPD-related hospitalization, and the factors important for their selection. METHODS AND RESULTS: Cox and logistic regression were used for both unadjusted and adjusted analyses...
November 20, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29127750/-cosyrel-an-efficient-fixed-combination-for-treatment-of-hypertension-stable-ishd-and-heart-failure
#19
Jiří Widimský
Fixed combinations of two or three drugs are being frequently used in cardiovascular diseases. This approach markedly increases adherence of the patients to prolonged therapy and thus leads to better control of the diseases. Fixed combinations are often used in hypertension and coronary artery disease (CAD). Cosyrel is the first fixed combination of betablocker (bisoprolol fumarat) and ACE inhibitor (perindopril arginin) available in czech market. The advantage is availability in several concentrations (10 mg/10 mg, 10 mg/5 mg a 5 mg/10 mg a 5 mg/5 mg) , when first indicates bisoprolol dose and the second perindopril...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29121091/effects-of-four-different-antihypertensive-drugs-on-plasma-metabolomic-profiles-in-patients-with-essential-hypertension
#20
Timo P Hiltunen, Jenni M Rimpelä, Robert P Mohney, Steven M Stirdivant, Kimmo K Kontula
OBJECTIVE: In order to search for metabolic biomarkers of antihypertensive drug responsiveness, we measured >600 biochemicals in plasma samples of subjects participating in the GENRES Study. Hypertensive men received in a double-blind rotational fashion amlodipine, bisoprolol, hydrochlorothiazide and losartan, each as a monotherapy for one month, with intervening one-month placebo cycles. METHODS: Metabolomic analysis was carried out using ultra high performance liquid chromatography-tandem mass spectrometry...
2017: PloS One
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