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Jing Chen, Xiaoli Tian, Zijie Mei, Yacheng Wang, Ye Yao, Shimin Zhang, Xin Li, Hui Wang, Junhong Zhang, Conghua Xie
CpG-oligodeoxynucleotide (CpG-ODN) is not only reported to protect against airway hyper responsiveness but is also known as a potent vaccine adjuvant for anti-tumor therapy. Little is known about the effect of CpG-ODN in mice with radiation-induced lung fibrosis (RILF), a common late stage form of tissue damage that occurs after thorax radiotherapy (RT). Here, we evaluated the immunomodulatory effects of CpG-ODN on the development of RILF. Mice were divided into four groups: (1) RT, single dose of 12Gy to the whole thorax; (2) CpG, only intraperitoneal injection of CpG-ODN for total 5 weeks; (3) RT+CpG, irradiation plus CpG-ODN treatment before and after irradiation for total 5 weeks; and (4) control (CTL): No RT or CpG-ODN treatment...
December 2016: Molecular Immunology
Xiao-Yan Cai, Xiao-Chun Ni, Yong Yi, Hong-Wei He, Jia-Xing Wang, Yi-Peng Fu, Jian Sun, Jian Zhou, Yun-Feng Cheng, Jian-Jun Jin, Jia Fan, Shuang-Jian Qiu
Nucleoside triphosphate diphosphohydrolase-1 (ENTPD1/CD39) is the rate-limiting enzyme in a cascade leading to the generation of immunosuppressive adenosine and plays an important role in tumor progression. This study aimed to evaluate the expression of CD39 and CD39Foxp3 regulatory T cells (Tregs) and to determine their prognostic role in patients with hepatocellular carcinoma (HCC) after radical resection.Immunohistochemistry (IHC) and double IHC were used to analyze CD39 expression or the expression of CD39 and Foxp3 in a cohort of 324 HCC patients who underwent curative resection...
October 2016: Medicine (Baltimore)
E Y Choi, S S Lee, J Y Hyeon, S H Choe, B R Keum, J M Lim, D C Park, I S Choi, K K Cho
This research analyzed the effect of β-glucan that is expected to alleviate the production of the inflammatory mediator in macrophagocytes, which are processed by the lipopolysaccharide (LPS) of Escherichia. The incubated layer was used for a nitric oxide (NO) analysis. The DNA-binding activation of the small unit of nuclear factor-κB was measured using the enzyme-linked immunosorbent assay-based kit. In the RAW264.7 cells that were vitalized by Escherichia coli (E. coli) LPS, the β-glucan inhibited both the combatant and rendering phases of the inducible NO synthase (iNOS)-derived NO...
November 2016: Asian-Australasian Journal of Animal Sciences
C Y Liu, M Y Zheng, R Fu, H Q Wang, T Wang, W W Qi, Z H Shao
OBJECTIVE: To clarify the specific target of severe aplastic anemia (SAA) immune attack via identifying the target cells of cytotoxic T cell attacks and the expression of apoptosis ligand on each department and each stage of bone marrow hematopoietic cells. METHODS: A total of 15 SAA patients and 15 normal controls were recruited in the Department of Hematology, Tianjin Medical University General Hospital between March 2011 and March 2012. Factor associated suicide(Fas) protein expression of CD34(+) , CD14(+) , CD33(+) , and GlycoA(+) cells in bone marrow was detected by flow cytometry...
June 14, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Yanhong Li, Jigang Zhang, Yanfeng Xu, Yunlin Han, Binbin Jiang, Lan Huang, Hua Zhu, Yuhuan Xu, Weiling Yang, Chuan Qin
The biological effects of different wavelengths of light emitting diode (LED) light tend to vary from each other. Research into use of photobiomodulation for treatment of skin wounds and the underlying mechanisms has been largely lacking. We explored the histopathological basis of the therapeutic effect of photobiomodulation and the relation between duration of exposure and photobiomodulation effect of different wavelengths of LED in a Japanese big-ear white rabbit skin-wound model. Skin wound model was established in 16 rabbits (three wounds per rabbit: one served as control, the other two wounds were irradiated by red and blue LED lights, respectively)...
2016: PloS One
Wenxia Fan, Fenghua Qian, Qinlong Ma, Pei Zhang, Tingting Chen, Chunhai Chen, Yong Zhang, Ping Deng, Zhou Zhou, Zhengping Yu
OBJECTIVE: To investigate the effects of extremely low frequency electromagnetic field (ELF-EMF) on the proliferation and cytokine production of mesenchymal stem cells (MSC) and the effects of mesenchymal stem cell conditioned medium (MSC-CM) on the proliferation and migration of macrophagocytes (RAW264.7). METHODS: Bone marrow derived-mesenchymal stem cells (rBMSC) were isolated from rats, cultured and randomly divided into two groups: SHAM group (absence of electromagnetic field exposure) and EMF group...
2015: International Journal of Clinical and Experimental Medicine
Hongli Yu, Yaozong Pan, Hao Wu, Xiuyun Ge, Qian Zhang, Fagen Zhu, Baochang Cai
UNLABELLED: The present study aimed at investigating the alum-processing mechanism attenuating toxicity of Araceae Pinellia ternata and Pinellia pedatisecta. Animal retroperitoneal inflammatory model in vivo and macrophagocyte release inflammatory factor model in vitro were used to detect the effect of alum processing on raphides and lectin. Scanning electron microscopy was used to observe the change in raphides during processing; HPLC method was used to determine the correlation between the dissolution and corrosion of raphides and ion in the alum solution; (27)Al-NMR technology was used to detect the relationship between aluminum oxalate complex formation and the dissolved and corrosion of raphides...
October 2015: Archives of Pharmacal Research
Ting-Ting Ma, Bi-Tao Wu, Yan Lin, Hai-Yu Xiong, Qin Wang, Zi-Wei Li, Feng Cheng, Zhi-Guang Tu
Interleukin-12 (IL-12), a member of interleukin family, plays a critical role in immune responses and anti-tumor activity. In this study, the effects of IL-12 on monocytic tumor cell lines differentiation to macrophagocyte and its likely mechanism was investigated. We examined the differentiation markers, morphological and functional changes, and possible mechanism in IL-12-treated THP-1 and U937 cells. It was found that IL-12 could up-regulated macrophage surface marker CD68 and CD11b expression in a time-dependent manner...
April 2015: Molecular and Cellular Biochemistry
Yanxia Fu, Hailing Zhou, Mengqi Wang, Juren Cen, Qun Wei
Isogarcinol is a natural compound that we extracted from Garcinia mangostana L., and we were the first to report that it is a new immunosuppressant. In the present study, we investigated the immune regulation and anti-inflammatory effects of isogarcinol on collagen-induced arthritis (CIA) and explored its potential mechanism in the treatment of rheumatoid arthritis. The oral administration of isogarcinol significantly reduced clinical scores, alleviated cartilage and bone erosion, and reduced the levels of serum inflammatory cytokines in CIA mice...
May 7, 2014: Journal of Agricultural and Food Chemistry
V A Ameliushkina, S Zh Urazalina, T I Kotkina, S I Kaba, V N Titov
The clinical and pathomorphologic data demonstrate that the most frequent cause of cardiac infarction is the formation of "soft" atheromatosis plaques in the intima of arteries. Their rupture results in thrombosis of coronary arteries. The plaques are characterized by higher content of triglycerides. On the basis of the research data, it is possible to validly consider that the detection of secretary phospholipase content A2 conjugated with lipoproteins is the test of systemic inflammatory response. This response is formed under atherosclerosis in vivo as a feedback to the accumulation in the intercellular medium of the endogenic flogogens (initiators of biological reaction of inflammation)--lipoproteins of lower density subclass A...
March 2012: Klinicheskaia Laboratornaia Diagnostika
Stefan Prokop, Frank L Heppner, Hans H Goebel, Werner Stenzel
The etiopathogenesis of sarcoidosis, a systemic granulomatous disease, still remains obscure. A multitude of organs have been described to be affected in systemic sarcoidosis. Skeletal muscles may also be affected, leading to myalgia and weakness. A workup of the specific immune response with emphasis on the macrophage response is provided herein. Affected muscle tissue from seven patients with systemic sarcoidosis was analyzed and compared with that from seven patients with other myopathies containing macrophagocytic infiltration...
March 2011: American Journal of Pathology
Yu Niu, Ai-Li He, Wang-Gang Zhang
Hemophagocytic lymphohistiocytosis (HLH) is named as hemophagocytic syndrome (HPS) and is a complicated disease with reactive hyperplasia of mononuclear/macrophagocytic system. This disease characterised by release of massive cytokines and severe functional destruction of visceral organs, which results from immune function disturbance causing by various pathogenic factors. The cardinal clinical symptoms of HLH are prolonged fever, hepatosplenomegaly, cytopenia, elevated ferritin and triglycerides, low fibrinogen, symptom in nerve system and so on...
February 2010: Zhongguo Shi Yan Xue Ye Xue za Zhi
H Noguchi
The pathological changes observed in the organs in Macacus rhesus monkeys which have succumbed to severe infection with Bartonella bacilliformis are similar to those found in human organs in persons dying of Oroya fever. The characteristic changes in the liver are the zonal necrosis of the cells around the hepatic veins, involving active macrophagocytosis of invading polymorphonuclear leucocytes in the necrotic areas, and a marked endothelial hyperplasia in the sinusoids or around the portal veins. In some instances there is fatty infiltration of hepatic cells...
February 28, 1927: Journal of Experimental Medicine
Yong-Qing Zhang, Gao-Sheng Huang, Xie-Qun Chen, Qing-Xian Bai, Rong Liang, Zhe Wang
This study was purposed to investigate the changes of bcl-6 expression in K562 cells and the mechanism inducing differentiation into different myelocyte lineages. Models of K562 cells inducing differentiation to lineages of megakaryocyte, erythrocyte and macrophagocyte were established with inducers TPA (tetradecanoylphorbol 13-acetate), Hu (hydroxyurea) and HMBA (hexamethylene bisacetamide) respectively. Western blot assay was applied to detect the expression of bcl-6 in K562 cells before and after the induction...
April 2009: Zhongguo Shi Yan Xue Ye Xue za Zhi
Shu-feng Yang, Jian-ning Zhao
Aseptic loosening is one of the most frequent long-term complications after joint replacement,which limits the service life of prostheses. A lot of studies have been focused on interface membranes around prostheses recently. In interface membranes, there are plenty of macrophagocytes and desmocytes,which play vital roles in osteolysis. This study gave a review of interface membrane including its formation, cellulosity, osteolysis factor, immunity reaction and turnover. The advances of interface membranes will help us to comprehend the pathogenesy and treatment of the aseptic loosening...
April 2008: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Yusu Ni, Xia Zhao, Liang Zhou, Zhengzhong Shao, Wenhong Yan, Xin Chen, Zhengbing Cao, Zhen Xue, Jack J Jiang
OBJECTIVES: To explore the feasibility of silk fibroin as a biomaterial coating used in tracheal defect reconstruction. METHODS: Silk fibroin was subcutaneously embedded in three rabbits and as an artificial implant material coating to reconstruct 12 rabbits' tracheal defects. The postoperative radiologic and histologic characterization was summarized. RESULTS: The thickness of the fibroblasts layer covering the porus and nonporus silk fibroin film was 240...
August 2008: Otolaryngology—Head and Neck Surgery
H-P Fischer, U Flucke, H Zhou
Sinusoidal alterations unrelated to primary hepatocellular damage present without characteristic clinical findings and in these cases the liver biopsy is particularly important. Capillarization of sinusoids is characterized by closing of fenestration, formation of a basal membrane and by the expression of CD34 and is typical for active cirrhosis. In nodular regeneratory hyperplasia, capillarization indicates a local or general disturbance of perfusion. In large regenerative nodules, focal nodular hyperplasia and liver cell adenoma CD34-positive capillaries reflect afferent parts and CD34-negative sinusoids the efferent parts of the parenchymal vascular bed...
February 2008: Der Pathologe
Rie Tanioka, Shinichiro Mori, Takahisa Nakanishi, Shinya Fujita, Naoto Nakamichi, Kenichiro Tajima, Yoshiko Uemura, Ryuichi Amakawa, Yuji Kishimoto, Shirou Fukuhara
A 69-year-old man was admitted to our hospital with fever and right neck lymphadenopathy. A neck lymph node biopsy was performed. In the specimens, immunoblasts were present with an admixture of small T lymphocytes and macrophagocytes. Immunohistochemcal staining of immunoblasts was positive for CD20, CD30 and EBER. Epstein-Barr virus (EBV) serology showed elevated IgG antibody to VCA, and EBV DNA was detected in the peripheral blood. Since he showed latency II without immunodeficiency disease, we diagnosed age-related EBV-associated B-cell lymphoproliferative disorder (EBV-LPD) as a result of aging and EBV infection...
November 2007: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
Junzhi Wang, Kun Zou, Yanming Zhang, Chuang Liu, Jun Wu, Yuan Zhou, Feijun Dan, Yaxiong Zhang
A novel 18-norspirostanol saponin (1), along with Trillenoside A (2), was obtained from the underground parts of Trillium tschonoskii MAXIM., collected in Shennongjia Forest District, China. Based on the chemical and spectroscopic evidences, their structures were determined as shown in Fig. 1. 1 and 2 displayed marked inhibitory action towards COX-2 production in macrophagocytes of the mouse abdominal cavity stimulated by LPS at 10 microg/ml.
April 2007: Chemical & Pharmaceutical Bulletin
An-long Zhu, Hong-chi Jiang, Lian-xin Liu, Da-xun Piao, Shang-ha Pan, Hai-quan Qiao
OBJECTIVE: To study the morphology and functional character of blood-spleen barrier (BSB) and establish the concept of BSB. METHODS: Thirty healthy Wistar rats were studied. Ten rats were injected with 1.5 ml mixed fluid of India ink and physiological saline through the tail vein. Histological changes of the spleen in all animals were observed with light and electron microscopy, including HE, Foot, Masson staining and immunohistochemistry of CD68 and CD34. RESULTS: Most of the carbon particles were within the splenic sinuses in marginal zone but not in the white pulp after 6 h...
May 1, 2005: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
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