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https://www.readbyqxmd.com/read/29917206/up-regulation-of-microrna-503-by-high-glucose-reduces-the-migration-and-proliferation-but-promotes-the-apoptosis-of-human-umbilical-vein-endothelial-cells-by-inhibiting-the-expression-of-insulin-like-growth-factor-1-receptor
#1
L-J Hou, J-J Han, Y Liu
OBJECTIVE: The present study is aimed to investigate the regulatory effect of microRNA (miRNA or miR)-503 on endothelial functions, as well as the mechanism by which high glucose leads to injury of endothelial cells. MATERIALS AND METHODS: When reaching 80% confluency, human umbilical vein endothelial cells (HUVECs) were subjected to non-serum synchronization for 12 h, and medium of cells in high-glucose (HG) group was replaced by normal medium supplemented with 25 mmol/L D-glucose...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917037/high-plasma-apolipoprotein-b-identifies-obese-subjects-who-best-ameliorate-white-adipose-tissue-dysfunction-and-glucose-induced-hyperinsulinemia-after-a-hypocaloric-diet
#2
Simon Bissonnette, Nathalie Saint-Pierre, Valerie Lamantia, Catherine Leroux, Viviane Provost, Yannick Cyr, Remi Rabasa-Lhoret, May Faraj
Background: To optimize the prevention of type 2 diabetes (T2D), high-risk obese subjects with the best metabolic recovery after a hypocaloric diet should be targeted. Apolipoprotein B lipoproteins (apoB lipoproteins) induce white adipose tissue (WAT) dysfunction, which in turn promotes postprandial hypertriglyceridemia, insulin resistance (IR), and hyperinsulinemia. Objective: The aim of this study was to explore whether high plasma apoB, or number of plasma apoB lipoproteins, identifies subjects who best ameliorate WAT dysfunction and related risk factors after a hypocaloric diet...
June 18, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29916742/glucose-variability-a-review-of-clinical-applications-and-research-developments
#3
David Rodbard
Glycemic variability (GV) is a major consideration when evaluating quality of glycemic control. GV increases progressively from prediabetes through advanced T2D and is still higher in T1D. GV is correlated with risk of hypoglycemia. The most popular metrics for GV are the %Coefficient of Variation (%CV) and standard deviation (SD). The %CV is correlated with risk of hypoglycemia. Graphical display of glucose by date, time of day, and day of the week, and display of simplified glucose distributions showing % of time in several ranges, provide clinically useful indicators of GV...
June 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29916714/quantitative-proteomics-and-phosphoproteomics-analysis-revealed-different-regulatory-mechanisms-of-halothane-and-rendement-napole-genes-in-porcine-muscle-metabolism
#4
Honggang Huang, Tracy L Scheffler, David E Gerrard, Martin R Larsen, Rene Lametsch
Pigs with the Halothane (HAL) and/or Rendement Napole (RN) gene mutations demonstrate abnormal muscle energy metabolism patterns and produce meat with poor quality, classified as pale, soft and exudative (PSE) meat, but it is not well understood how HAL and RN mutations regulate glucose and energy metabolism in porcine muscle. In order to investigate the potential signaling pathways and phosphorylation events related to these mutations, muscle samples were collected from four genotypes of pigs: wildtype, RN, HAL and RN-HAL double mutations and subjected to quantitative proteomic and phosphoproteomic analysis using the TiO2 enrichment strategy...
June 19, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29916308/the-mtor-pathway-regulates-pkm2-to-affect-glycolysis-in-esophageal-squamous-cell-carcinoma
#5
He Xiaoyu, Yin Yiru, Shi Shuisheng, Cheng Keyan, Yan Zixing, Cheng Shanglin, Wang Yuan, Cheng Dongming, Zhang Wangliang, Bai Xudong, Ma Jie
OBJECTIVES: Esophageal squamous cell carcinoma is a highly prevalent cancer withpoor survival rate and prognosis. Increasing evidence suggests an important role for metabolic regulation in treating esophageal squamous cell carcinoma, but the underlying mechanism remains unclear. The pyruvate kinase M2 isoform is a key enzyme in the energy production process, and the upregulation of pyruvate kinase M2 isoform also plays a crucial role in gene transcription and tumorigenesis. The mammalian target of rapamycin pathway regulates an array of cellular functions, including protein synthesis, metabolism, and cell proliferation...
January 1, 2018: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29916137/high-serum-osteopontin-levels-are-associated-with-prevalent-fractures-and-worse-lipid-profile-in-post-menopausal-women-with-type-2-diabetes
#6
T Filardi, V Carnevale, R Massoud, C Russo, L Nieddu, F Tavaglione, I Turinese, A Lenzi, E Romagnoli, S Morano
PURPOSE: Patients with type 2 diabetes (T2DM) have increased fracture risk. Osteopontin (OPN) is a protein involved in bone remodeling and inflammation. The aim of this study was to evaluate the association of OPN with fracture prevalence and with metabolic parameters in post-menopausal women with T2DM. METHODS: Sixty-four post-menopausal women with T2DM (age 67.0 ± 7.8 years, diabetes duration 8.9 ± 6.7 years), enrolled in a previous study, were followed up (3...
June 18, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29916117/mapping-bone-marrow-response-in-the-vertebral-column-by-positron-emission-tomography-following-radiotherapy-and-erlotinib-therapy-of-lung-cancer
#7
Azadeh Abravan, Hanne Astrid Eide, Ayca Muftuler Løndalen, Åslaug Helland, Eirik Malinen
PURPOSE: To map functional bone marrow (BM) by 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) positron emission tomography (PET) in the vertebral column of lung cancer patients prior to, during, and after treatment. Moreover, to identify radiation- and erlotinib-induced changes in the BM. PROCEDURES: Twenty-six patients with advanced non-small cell lung cancer, receiving radiotherapy (RT) alone or concomitantly with erlotinib, were examined by [18 F]FDG PET before, during, and after treatment...
June 18, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29915972/intestinal-glucose-absorption-was-reduced-by-vertical-sleeve-gastrectomy-via-decreased-gastric-leptin-secretion
#8
Jinpeng Du, Chaojie Hu, Jie Bai, Miaomiao Peng, Qingbo Wang, Ning Zhao, Yu Wang, Guobin Wang, Kaixiong Tao, Geng Wang, Zefeng Xia
BACKGROUND: The unique effects of gastric resection after vertical sleeve gastrectomy (VSG) on type 2 diabetes mellitus remain unclear. This work aimed to investigate the effects of VSG on gastric leptin expression and intestinal glucose absorption in high-fat diet-induced obesity. METHODS: Male C57BL/6J mice were fed a high-fat diet (HFD) to induce obesity. HFD mice were randomized into VSG and sham-operation groups, and the relevant parameters were measured at 8 weeks postoperation...
June 18, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29915538/efficacy-and-safety-of-once-weekly-semaglutide-for-the-treatment-of-type-2-diabetes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#9
Fang-Hong Shi, Hao Li, Min Cui, Zai-Li Zhang, Zhi-Chun Gu, Xiao-Yan Liu
Background: Semaglutide, a newly once-weekly glucagon like peptide-1 (GLP-1) receptor agonist, has showed a favorable effect on glycaemic control and weight reduction in type 2 diabetes mellitus (T2DM). This meta-analysis was conducted to evaluate the clinical efficacy and safety of semaglutide in T2DM. Methods: A comprehensive searching was performed for Phase III randomized controlled trials (RCTs) which reported the efficacy and safety data of semaglutide and other therapies. The efficacy data expressed as weight mean difference (WMD) and the safety data expressed as risk ratios (RRs) were calculated by employing random-effects model...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29915365/metabolic-effects-of-genetic-variation-in-the-human-repin1-gene
#10
Jacqueline Krüger, Claudia Berger, Kerstin Weidle, Dorit Schleinitz, Anke Tönjes, Michael Stumvoll, Matthias Blüher, Peter Kovacs, Nora Klöting
BACKGROUND: Replication initiator 1 (Repin1) is a zinc finger protein highly expressed in liver and adipose tissue. The Repin1 resides within a quantitative trait locus (QTL) for body weight and triglyceride levels in the rat, and its hepatic deletion in mice results in improved insulin sensitivity and lower body weight. Here, we analyzed whether genetic variation within the Repin1 affects parameters of glucose and lipid metabolism. METHODS: We sequenced REPIN1 in 48 non-related Caucasian subjects...
June 18, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29915361/amp-kinase-promotes-glioblastoma-bioenergetics-and-tumour-growth
#11
Rishi Raj Chhipa, Qiang Fan, Jane Anderson, Ranjithmenon Muraleedharan, Yan Huang, Georgianne Ciraolo, Xiaoting Chen, Ronald Waclaw, Lionel M Chow, Zaza Khuchua, Matthew Kofron, Matthew T Weirauch, Ady Kendler, Christopher McPherson, Nancy Ratner, Ichiro Nakano, Nupur Dasgupta, Kakajan Komurov, Biplab Dasgupta
Stress is integral to tumour evolution, and cancer cell survival depends on stress management. We found that cancer-associated stress chronically activates the bioenergetic sensor AMP kinase (AMPK) and, to survive, tumour cells hijack an AMPK-regulated stress response pathway conserved in normal cells. Analysis of The Cancer Genome Atlas data revealed that AMPK isoforms are highly expressed in the lethal human cancer glioblastoma (GBM). We show that AMPK inhibition reduces viability of patient-derived GBM stem cells (GSCs) and tumours...
June 18, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29915239/non-communicable-disease-risk-factor-profile-among-public-employees-in-a-regional-city-in-northern-ethiopia
#12
Lemlem Weldegerima Gebremariam, Chifa Chiang, Hiroshi Yatsuya, Esayas Haregot Hilawe, Alemayehu Bayray Kahsay, Hagos Godefay, Loko Abraham, Yoshihisa Hirakawa, Hiroyasu Iso, Atsuko Aoyama
The burden of non-communicable diseases (NCDs) is increasing in Ethiopia. This study aims to describe the prevalence of NCD risk factors of public employees in a regional city in northern Ethiopia. We conducted a cross-sectional epidemiological study targeting men and women aged 25-64 years employed by public offices in Mekelle. The prevalence was age-standardized to the Ethiopian 2007 population. Among the 1380 subjects (823 men and 557 women), 68.7% had less than 1 serving of fruits and vegetables per day, 41...
June 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29915142/impaired-%C3%AE-cell-glucokinase-as-an-underlying-mechanism-in-diet-induced-diabetes
#13
Brian Lu, Kiran Kurmi, Miguel Munoz-Gomez, Egon J Jacobus Ambuludi, Jason M Tonne, Kuntol Rakshit, Taro Hitosugi, Yogish C Kudva, Aleksey V Matveyenko, Yasuhiro Ikeda
High-fat diet (HFD)-fed mouse models have been widely used to study early type 2 diabetes. Decreased β-cell glucokinase (GCK) expression has been observed in HFD-induced diabetes. However, owing to its crucial roles in glucose metabolism in the liver and in islet β-cells, the contribution of decreased GCK expression to the development of HFD-induced diabetes is unclear. Here, we employed a β-cell-targeted gene transfer vector and determined the impact of β-cell-specific increase in GCK expression on β-cell function and glucose handling in vitro and in vivo Overexpression of GCK enhanced glycolytic flux, ATP-sensitive potassium channel activation and membrane depolarization, and increased proliferation in Min6 cells...
June 13, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29914986/glpr-is-a-direct-transcriptional-repressor-of-fructose-metabolic-genes-in-haloferax-volcanii
#14
Jonathan H Martin, Katie Sherwood Rawls, Jou Chin Chan, Sungmin Hwang, Mar Martinez-Pastor, Lana J McMillan, Laurence Prunetti, Amy K Schmid, Julie A Maupin-Furlow
DeoR-type helix-turn-helix (HTH) domain proteins are transcriptional regulators of sugar and nucleoside metabolism in diverse bacteria and occur in select archaea. In the model archaeon Haloferax volcanii , previous work implicated GlpR, a DeoR-type transcriptional regulator, in transcriptional repression of glpR and the gene encoding the fructose-specific phosphofructokinase ( pfkB ) during growth on glycerol. However, the global regulon governed by GlpR remained unclear. Here we compared transcriptomes of wild type and Δ glpR mutant strains grown on glycerol and glucose to detect significant transcript level differences for nearly 50 new genes regulated by GlpR...
June 18, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29914938/amino-acid-and-lipid-associated-plasma-metabolomic-patterns-are-related-to-healthspan-indicators-with-aging-in-humans
#15
Lawrence C Johnson, Christopher R Martens, Jessica R Santos-Parker, Candace J Bassett, Talia R Strahler, Charmion Cruickshank-Quinn, Nichole Reisdorph, Matthew B McQueen, Douglas R Seals
Advancing age is associated with impairments in numerous physiological systems, leading to an increased risk of chronic disease and disability, and reduced healthspan (the period of high functioning healthy life). The plasma metabolome is thought to reflect changes in the activity of physiological systems that influence healthspan. Accordingly, we utilized an LC-MS metabolomics analysis of plasma collected from healthy young and older individuals to characterize global changes in small molecule abundances with age...
June 18, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29914888/a-diverse-lipid-antigen-specific-tcr-repertoire-is-clonally-expanded-during-active-tuberculosis
#16
William S DeWitt, Krystle K Q Yu, Damien B Wilburn, Anna Sherwood, Marissa Vignali, Cheryl L Day, Thomas J Scriba, Harlan S Robins, Willie J Swanson, Ryan O Emerson, Philip H Bradley, Chetan Seshadri
Human T cells that recognize lipid Ags presented by highly conserved CD1 proteins often express semi-invariant TCRs, but the true diversity of lipid Ag-specific TCRs remains unknown. We use CD1b tetramers and high-throughput immunosequencing to analyze thousands of TCRs from ex vivo-sorted or in vitro-expanded T cells specific for the mycobacterial lipid Ag, glucose monomycolate. Our results reveal a surprisingly diverse repertoire resulting from editing of germline-encoded gene rearrangements analogous to MHC-restricted TCRs...
June 18, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29914776/cerebrospinal-fluid-lactate-concentration-and-bacterial-encephalitis-diagnosis
#17
M Maillet, T De Broucker, A Mailles, P Bouzat, J P Stahl
OBJECTIVES: A French national study on infectious encephalitis enrolled 253 patients in 2007. Fifty-two per cent of patients had a proven etiological diagnosis; 16% had bacterial encephalitis. We aimed to assess the predictive value of CSF lactate concentration to diagnose bacterial encephalitis. PATIENTS AND METHODS: Patients from the 2007 cohort whose CSF lactate concentration was available were included. Clinical and biological features associated with a bacterial etiology were assessed using univariate analysis and multivariate logistic regression...
June 15, 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29914667/methylation-in-3-near-region-of-gc-gene-and-its-association-with-the-level-of-vitamin-d-binding-protein-and-type-2-diabetes-mellitus
#18
Songcheng Yu, Yan Wang, Xing Li, Zhenxing Mao, Fei Yu, Ling Wang, Yue Ba, Chongjian Wang, Wenjie Li
As the major vitamin D binding protein (DBP), the group-specific component (GC) plays an important role in the bioactivity of vitamin D. Abnormal expression of GC gene may be associated with vitamin D related disease, type 2 diabetes mellitus (T2DM). DNA methylation is an important regulator of gene expression. It has been reported that methylation in 3' untranslated region played a role in regulation of protein expression via interaction with miRNA. This study hypothesized that DNA methylation of 3' near region of GC gene (3'GC) might be associated with T2DM...
June 2018: Nutrition Research
https://www.readbyqxmd.com/read/29914537/combination-therapy-of-ipilimumab-and-nivolumab-induced-thyroid-storm-in-a-patient-with-hashimoto-s-disease-and-diabetes-mellitus-a-case-report
#19
Kazuko Yonezaki, Toshihiro Kobayashi, Hitomi Imachi, Takuo Yoshimoto, Fumi Kikuchi, Kensaku Fukunaga, Seisuke Sato, Tomohiro Ibata, Nao Yamaji, Jingya Lyu, Tao Dong, Koji Murao
BACKGROUND: Recently, immune checkpoint inhibitors have widely been used for the management of advanced melanoma. However, high-grade immune-related adverse events can occur, particularly with combination immunotherapy. We report a case of a patient with melanoma who developed thyroid storm following treatment with ipilimumab and nivolumab. CASE PRESENTATION: An 85-year-old Japanese man with a history of malignant melanoma presented to our department with severe thyrotoxicosis and poor blood glucose control...
June 19, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29914251/visfatin-levels-in-hormonally-inactive-adrenal-adenoma-and-their-association-with-metabolic-parameters
#20
Alp Atasoy, Evrim Çakır, Süleyman Ahbab, Yasemin Erdoğan Döventaş, Macit Koldaş, Esra Ataoğlu, Mustafa Yenigün
Background/aim: In parallel with increased frequency and higher quality of imaging techniques, the prevalence of adrenal adenoma has gradually increased. However, despite the growing incidence, the metabolic and tumorigenesis processes involved in its etiology are still unclear. Although visfatin has been reported to be associated with inflammation and tumorigenesis, its role in adrenal adenoma has not yet been investigated. Therefore, the present study was performed with an aim to evaluate visfatin levels and cardiometabolic risk factors in patients with adrenal adenoma...
June 14, 2018: Turkish Journal of Medical Sciences
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