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https://www.readbyqxmd.com/read/29454073/the-accumulation-of-assembly-intermediates-of-the-mitochondrial-complex-i-matrix-arm-is-reduced-by-limiting-glucose-uptake-in-a-neuronal-like-model-of-melas-syndrome
#1
Guillaume Geffroy, Rayane Benyahia, Samuel Frey, Valerie Desquiret-Dumas, Naig Gueguen, Celine Bris, Sophie Belal, Aurore Inisan, Aurelie Renaud, Arnaud Chevrollier, Daniel Henrion, Dominique Bonneau, Franck Letournel, Guy Lenaers, Pascal Reynier, Vincent Procaccio
Ketogenic diet (KD) which combined carbohydrate restriction and the addition of ketone bodies has emerged as an alternative metabolic intervention used as an anticonvulsant therapy or to treat different types of neurological or mitochondrial disorders including MELAS syndrome. MELAS syndrome is a severe mitochondrial disease mainly due to the m.3243A > G mitochondrial DNA mutation. The broad success of KD is due to multiple beneficial mechanisms with distinct effects of very low carbohydrates and ketones...
February 14, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29454024/development-of-an-in-vitro-screening-method-of-acute-cytotoxicity-of-the-pyrrolizidine-alkaloid-lasiocarpine-in-human-and-rodent-hepatic-cell-lines-by-increasing-susceptibility
#2
Kristina Forsch, Verena Schöning, Lucia Disch, Beate Siewert, Matthias Unger, Jürgen Drewe
ETHNOPHARMACOLOGICAL RELEVANCE: Pyrrolizidine alkaloids (PAs) are secondary plant ingredients formed in many plant species to protect against predators. PAs are generally considered acutely hepatotoxic, genotoxic and carcinogenic. Up to now, only few in vitro and in vivo investigations were performed to evaluate their relative toxic potential. AIM OF THE STUDY: The aim was to develop an in vitro screening method of their cytotoxicity. MATERIALS AND METHODS: Human and rodent hepatocyte cell lines (HepG2 and H-4-II-E) were used to assess cytotoxicity of the PA lasiocarpine...
February 14, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29453986/sterol-o-acyltransferase-1-deficiency-improves-defective-insulin-signaling-in-the-brains-of-mice-fed-a-high-fat-diet
#3
Ning Xu, Hao Meng, Tian-Yi Liu, Ying-Li Feng, Yuan Qi, Dong-Huan Zhang, Hong-Lei Wang
Insulin resistance induced by a high-fat diet (HFD) is related to metabolic diseases, and sterol O-acyltransferase 1 (SOAT1) is a key enzyme for the biosynthesis of cholesteryl ester. In the present study, wild-type (WT) mice and SOAT1-knockout (KO) mice with a C57BL6 background fed a HFD were used to explore the role of SOAT1 in the hypothalamus. The results show that the WT mice exhibited a significant increase in body weight as well as hepatic histologic changes; they also had a lower glucose and insulin tolerance than the WT mice fed a normal diet...
February 14, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29453983/aldolase-a-overexpression-is-associated-with-poor-prognosis-and-promotes-tumor-progression-by-the-epithelial-mesenchymal-transition-in-colon-cancer
#4
Feng Ye, Yixing Chen, Lu Xia, Jiabian Lian, Shuyu Yang
There is increasing evidence that glycolysis is involved in cancer progression. Aldolase is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. Disruption of the aldolase genes also plays a role in the progression of multiple types of cancer. However, the underlying mechanism of the action of aldolases in colon cancer progression remains elusive. In this study, aldolase A expression was investigated and found to be upregulated along with human colon cancer progression and metastasis at both the mRNA and protein levels in human colon cancer tissues...
February 14, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29453918/high-dose-of-histone-deacetylase-inhibitors-affects-insulin-secretory-mechanism-of-pancreatic-beta-cell-line
#5
Eiji Yamato
OBJECTIVE: Histone deacytylase inhibitors (HDACis) inhibit the deacetylation of the lysine residue of proteins, including histones, and regulate the transcription of a variety of genes. Recently, HDACis have been used clinically as anti-cancer drugs and possible anti-diabetic drugs. Even though HDACis have been proven to protect the cytokine-induced damage of pancreatic beta cells, evidence also shows that high doses of HDACis are cytotoxic. In the present study, we, therefore, investigated the eff ect of HDACis on insulin secretion in a pancreatic beta cell line...
January 1, 2018: Endocrine Regulations
https://www.readbyqxmd.com/read/29453556/effects-of-increasing-dietary-protein-supplies-on-milk-yield-milk-composition-and-nitrogen-use-efficiency-in-lactating-buffalo
#6
Muhammad Naveed-Ul-Haque, Muhammad Uzair Akhtar, Rizwan Munnawar, Saba Anwar, Anjum Khalique, Murtaza Ali Tipu, Fayyaz Ahmad, Muhammad Qamer Shahid
Nitrogen efficiency of lactating buffalo can be increased by providing dietary crude protein (CP) precisely to the requirement. Twelve lactating Nili-Ravi buffaloes (6 primiparous and 6 multiparous) at 76 ± 37.5 days in milk (DIM) were used in this study. The treatments were diets providing three levels of CP (% DM basis): (1) low-protein = 11%; (2) medium-protein = 13.1%; (3) high-protein = 14.2% according to a 3 × 3 Latin square design. The period length of each treatment was 21 days and the total duration of experiment was 63 days...
February 16, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29453461/roux-en-y-gastric-bypass-and-sleeve-gastrectomy-induces-specific-shifts-of-the-gut-microbiota-without-altering-the-metabolism-of-bile-acids-in-the-intestinal-lumen
#7
Henri Duboc, Caroline Chong Nguyen, Jean-Baptiste Cavin, Lara Ribeiro-Parenti, Anne-Charlotte Jarry, Dominique Rainteau, Lydie Humbert, Benoit Coffin, Maude Le Gall, André Bado, Harry Sokol
Some shifts in the gut microbiota composition and its metabolic fingerprints have been associated to Sleeve gastrectomy (SG) and Roux-en-Y Gastric Bypass (RYGB). So far, plasma bile acids have been associated with post-operative glucose improvement and weight loss, but nothing is known about their metabolism in the gut lumen. As bile acids are physiologically transformed by the microbiota into various species, the aim of this work was to study how SG and RYGB-associated dysbiosis impact the bioconversion of bile acids in the intestinal lumen...
January 30, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29453165/endoscopic-submucosal-dissection-for-the-diagnosis-and-therapy-of-pedunculated-gastric-cancer-with-prolapse-into-the-duodenal-bulb-a-case-report
#8
Norihiko Suzuki, Masashi Yoshida, Hironori Ohdaira, Tomonori Imakita, Nobuhiro Tsutsui, Yasunobu Kobayashi, Junji Takahashi, Shinya Okada, Masaki Kitajima, Yutaka Suzuki
INTRODUCTION: Preoperative diagnosis of gastric cancer invasion is not always sufficiently accurate. Diagnostic endoscopic submucosal dissection (ESD) can be performed for the purpose of accurate decision making and to avoid partial treatment vs aggressive over-treatment. We present a patient with the gastric cancer with indeterminate pre-operative diagnosis for depth of the invasion. CASE PRESENTATION: A 70-year-old man presented at our hospital because both anti-Helicobacter pylori (Hp) IGG antibody and serum pepsinogen (PG) levels were classified as positive...
February 9, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29452900/prevalence-and-correlates-of-hypertension-outcome-of-a-free-medical-screening-in-oke-ogun-area-of-oyo-state-nigeria-west-africa
#9
REVIEW
Rasaki O Shittu, Louis O Odeigah, Kasali O Fakorede, Biliaminu A Sikiru, Abdullateef G Sule, Yusuf Musah, Folorunsho M Adeyemi
Literature abounds on prevalence of hypertension in Nigeria and urban areas of Oyo state but none in Oke-Ogun geopolitical zone, which constitutes 10 local governments of the 33 in Oyo state, despite the fact that they have high genetic and environmental predisposition to developing high blood pressure. The purpose of the study was to determine the prevalence of high blood pressure and associated risk factors among indigenes of Oke-ogun, Oyo state. A total of 10,000 respondents were recruited using proportionate sampling techniques...
February 1, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29452425/clinical-evidence-on-dietary-supplementation-with-chia-seed-salvia-hispanica-l-a-systematic-review-and-meta-analysis
#10
Siew Li Teoh, Nai Ming Lai, Possatorn Vanichkulpitak, Vladimir Vuksan, Hoang Ho, Nathorn Chaiyakunapruk
Context: Chia seed is a popular dietary supplement, taken mainly for its high content of alpha-linolenic acid, vegetable protein, and dietary fiber, yet information about its clinical effects is lacking. Objective: This review aims to summarize the clinical evidence regarding the use of chia seed for a wide variety of health conditions. Data Sources: A number of databases, including PubMed and Embase, were searched systematically. Study Selection: Randomized controlled trials that assessed the clinical effects of chia seed consumption in human participants were included...
February 14, 2018: Nutrition Reviews
https://www.readbyqxmd.com/read/29452393/no-copper-supplementation-in-a-corn-soybean-basal-diet-has-no-adverse-effects-on-late-phase-laying-hens-under-normal-and-cyclic-high-temperatures
#11
W X Li, Y Q Chen, L H Zhao, Q G Ma, J Y Zhang, C Ji
Over supplementation of copper (Cu) in animal diets may cause serious pollution in soil, water and harvested crops. To minimize the potential pollution, the effects of corn-soybean basal diet with or without supplementation of 8 mg Cu/kg on laying performance, plasma biochemical metabolic indices, and antioxidant status in laying hens were evaluated under normal and cyclic high temperatures. A total of 240 Hy-Line Brown laying hens were randomly allotted to 4 treatments with 6 replicates of 10 hens per replicate according to factorial design involved in 2 temperatures [normal temperature (NT) vs...
February 14, 2018: Poultry Science
https://www.readbyqxmd.com/read/29452274/control-of-thiol-maleimide-reaction-kinetics-in-peg-hydrogel-networks
#12
Lauren E Jansen, Lenny J Negrón-Piñeiro, Sualyneth Galarza, Shelly R Peyton
Michael-type addition reactions are widely used to polymerize biocompatible hydrogels. The thiol-maleimide modality achieves the highest macromer coupling efficiency of the reported Michael-type pairs, but the resulting hydrogel networks are heterogeneous, because polymerization is faster than the individual components can be manually mixed. The reactivity of the thiol dictates the overall reaction speed, which can be slowed in organic solvents and acidic buffers. Since these modifications also reduce the biocompatibility of resulting hydrogels, we investigated a series of biocompatible buffers and crosslinkers to decelerate gelation while maintaining high cell viability...
February 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29452268/high-prevalence-of-liver-fibrosis-among-european-adults-with-unknown-liver-disease-a-population-based-study
#13
Llorenç Caballería, Guillem Pera, Ingrid Arteaga, Lluís Rodríguez, Alba Alumà, Rosa Ma Morillas, Napoleón de la Ossa, Alba Díaz, Carmen Expósito, Dolores Miranda, Carmen Sánchez, Rosa Ma Prats, Marta Urquizu, Angels Salgado, Magda Alemany, Alba Martinez, Irfan Majeed, Núria Fabrellas, Isabel Graupera, Ramón Planas, Isabel Ojanguren, Miquel Serra, Pere Torán, Juan Caballería, Pere Ginès
BACKGROUND AND AIMS: Liver fibrosis is the main determinant of long-term outcome in chronic liver diseases. Little is known about prevalence of liver fibrosis in general population. Aim of the study was to investigate the prevalence of liver fibrosis in general adult population with unknown liver disease. METHODS: Population-based, cross-sectional study, performed in Barcelona metropolitan area. Subjects aged 18-75yr were identified randomly from citizens included in primary health care registry...
February 13, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29452266/healthy-brain-aging-interplay-between-reactive-species-inflammation-and-energy-supply
#14
REVIEW
O Garaschuk, H M Semchyshyn, V I Lushchak
Brains' high energy expenditure with preferable utilization of glucose and ketone bodies, defines the specific features of its energy homeostasis. The extensive oxidative metabolism is accompanied by a concomitant generation of high amounts of reactive oxygen, nitrogen, and carbonyl species, which will be here collectively referred to as RONCS. Such metabolism in combination with high content of polyunsaturated fatty acids creates specific problems in maintaining brains' redox homeostasis. While the levels of products of interaction between RONCS and cellular components increase slowly during the first two trimesters of individuals' life, their increase is substantially accelerated towards the end of life...
February 13, 2018: Ageing Research Reviews
https://www.readbyqxmd.com/read/29452240/the-effect-of-non-anti-tnf-targeting-biologics-and-small-molecules-on-insulin-resistance-in-inflammatory-arthritis
#15
REVIEW
Francesco Ursini, Emilio Russo, Piero Ruscitti, Roberto Giacomelli, Giovambattista De Sarro
Inflammatory arthritides are chronic diseases characterised by an increase in cardiovascular risk, largely attributable to the synergy between high-grade systemic inflammation and an elevated prevalence of traditional cardiovascular risk factors. Amongst the latter, insulin resistance and type 2 diabetes (T2D) play a key position. Previous studies demonstrated a potential insulin-sensiting effect of anti-TNF biologic medications. For converse, less is known about the role of newer biologics or small molecules...
February 13, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29452184/production-of-chitinase-from-escherichia-fergusonii-chitosanase-from-chryseobacterium-indologenes-comamonas-koreensis-and-its-application-in-n-acetylglucosamine-production
#16
Tae Il Kim, Dong Hyun Lim, Kwang Soo Baek, Sun Sik Jang, Beom Young Park, Vijayakumar Mayakrishnan
The important platform polysaccharide N-acetylglucosamine (GlcNAc) has great potential to be used in the fields of food, cosmetics, agricultural, pharmaceutical, medicine and biotechnology. This GlcNAc is being produced by traditional methods of environment-unfriendly chemical digestion with strong acids. Therefore, researchers have been paying more attention to enzymatic hydrolysis process for the production of GlcNAc. Hence, in this study, we isolated novel chitinase (Escherichia fergusonii) and chitosanase (Chryseobacterium indologenes, Comamonas koreensis) producing strains from Korean native calves feces, and developed the potential of an eco-friendly microbial progression for GlcNAc production from swollen chitin and chitosan by enzymatic degradation...
February 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29451991/exogenous-ketone-salts-do-not-improve-cognitive-responses-after-a-high-intensity-exercise-protocol-in-healthy-college-aged-males
#17
Hunter S Waldman, Steven A Basham, Ffi G Price, JohnEric W Smith, Harish Chander, Adam C Knight, Ben M Krings, Matthew J McAllister
This study examined the effects of a D-ß-hydroxybutyrate (ßHB) containing beverage on cognitive and performance measures during a bout of repeated Wingates. Fifteen healthy, college-aged males (mean ± SD age: 23.1 ± 2.4 years, height: 165.4 ± 2.0 cm, mass: 81.4 ± 9.2 kg) volunteered for the present study. Trial 1 consisted of baseline measures and familiarization for the protocol. During trials 2 and 3, subjects reported to the laboratory, after a 10 h fast, and ingested 11.38 grams of ßHB or a placebo (PLA) beverage 30 min before exercise...
February 16, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29451987/association-of-adiponectin-leptin-ratio-with-carbohydrate-and-lipid-metabolism-parameters-in-hiv-infected-patients-during-antiretroviral-therapy
#18
Catalin Tiliscan, Victoria Arama, Raluca Mihailescu, Daniela Munteanu, Diana Gabriela Iacob, Cristina Popescu, Remulus Catana, Anca Negru, Alina Lobodan, Stefan Sorin Arama
BACKGROUND: Adiponectin and leptin are adipose tissue hormones that regulate important lipid and glucose metabolic pathways. Our objective was to evaluate the interplay of these hormones described by the adiponectin/leptin ratio (ALR) in correlation to lipid and carbohydrate metabolism parameters in nondiabetic HIV-infected patients during antiretroviral therapy (ART). MATERIALS AND METHODS: We enrolled consecutive nondiabetic patients with confirmed HIV infection, undergoing stable ART regimens for at least six months...
February 16, 2018: Endocrine Research
https://www.readbyqxmd.com/read/29451831/high-dose-perinatal-folic-acid-supplementation-alters-insulin-sensitivity-in-sprague-dawley-rats-and-diminishes-the-expression-of-adiponectin
#19
Ayodele Olufemi Morakinyo, Titilola Aderonke Samuel, Funmileyi Olubajo Awobajo, Gabriel Olorunleke Oludare, Adekunle Mofolorunso
The possible intake of folate in excess of the recommended upper levels is a matter of critical importance. This study was conducted to investigate the effects of prenatal and postnatal high folic acid supplementation (FAS) on glucose tolerance, insulin sensitivity, lipid metabolism, and expression of adiponectin in rats. The study included 20 female rats divided into two groups: control group and FAS group (receiving high folic acid supplemented diet). Both groups of female rats were mated and pregnancy confirmed...
February 16, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29451589/active-brazilian-crack-cocaine-users-nutritional-anthropometric-and-drug-use-profiles
#20
Mariana Escobar, Juliana N Scherer, Cassia M Soares, Luciano S P Guimarães, Martine E Hagen, Lisia von Diemen, Flavio Pechansky
OBJECTIVE: To evaluate the nutritional status of crack users and to analyze its correlation with drug use profiles. METHODS: Cross-sectional study with 108 crack users. Anthropometric data were assessed through body mass index (BMI) and bioimpedance (BIA) measurements. A blood test to analyze hematocrit, hemoglobin, glucose, and lipid profiles was also performed. Crack use was determined through a standardized interview. RESULTS: Based on BMI and BIA, most individuals were eutrophic (about 70%)...
February 15, 2018: Revista Brasileira de Psiquiatria
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