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https://www.readbyqxmd.com/read/29457303/long-term-effects-of-art-what-do-animals-tell-us
#1
REVIEW
V Duranthon, P Chavatte-Palmer
Early stages of mammalian embryonic development are now known to be very sensitive to their microenvironment, with long term effects on fetal, postnatal and adult health, thus extending to these early stages the concept of Developmental Origin of Health and Disease (DoHaD). In this scientific context, and with 3% of births in developed countries, safety of Assisted Reproductive Techniques procedures becomes a matter of concern. Besides, embryo technologies in domestic mammals, using huge number of embryos, do not seem to evidence heavy impacts on adult phenotypes...
February 19, 2018: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29445485/esophageal-atresia-and-beckwith-wiedemann-syndrome-in-one-of-the-naturally-conceived-discordant-newborn-twins-first-report
#2
Gregorio Serra, Vincenzo Antona, Mandy Schierz, Davide Vecchio, Ettore Piro, Giovanni Corsello
Recent studies report a high incidence of monozygotic twinning in Beckwith-Wiedemann syndrome. A phenotypical discordance in monozygotic twins is rare. Twinning and Beckwith-Wiedemann syndrome show higher incidence in children born after assisted reproductive techniques. We report on the first observation of esophageal atresia and Beckwith-Wiedemann syndrome in one of the naturally conceived discordant monozygotic twins.
February 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29430151/azoospermia-factor-c-subregion-of-the-y-chromosome
#3
REVIEW
Mili Nailwal, Jenabhai B Chauhan
The azoospermia factor (AZF) region on the Y chromosome consists of genes required for spermatogenesis. Among the three subregions, the AZFc subregion located at the distal portion of AZF is the driver for genetic variation in Y chromosome. The candidate gene of AZFc is known as deleted in azoospermia gene, which is studied with interest because it is involved in germ cell development and most frequently deleted genes leading to oligozoospermia and azoospermia. Recently, two partial deletions in AZFc gr/gr and b2/b3 are characterized at the molecular level which showed homologous recombination between amplicons, affecting spermatogenesis process...
October 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29422163/the-impact-of-complementary-therapies-on-psychosocial-factors-in-women-undergoing-in-vitro-fertilization-ivf-a-systematic-literature-review
#4
Jenna A LoGiudice, Jenna Massaro
AIM: This review evaluates the impact of complementary therapies on psychosocial factors in women undergoing IVF. BACKGROUND: According to the CDC, nearly 7% of married women in the United States face infertility. Approximately 1.5% of all infants born in the U.S. annually are conceived through assisted reproductive technologies (ART), such as IVF. Women undergoing ART report distress, anxiety, and depression related to their treatment. Stress has been cited as the top reason why women terminate treatment...
February 2018: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/29417894/strong-heterogeneity-in-advances-in-cryopreservation-techniques-in-the-mammalian-orders
#5
Sebastian J Charlton, Mikkel B Nielsen, Carina R Pedersen, Lisette Thomsen, Mads P Kristjansen, Thomas B Sørensen, Cino Pertoldi, Julie Strand
Between 1970 and 2012, vertebrate abundance has declined by 58% with an average annual decline of 2%, calling for serious action to prevent a mass extinction and an irreversible loss of biodiversity. Cryobanks and cryopreservation have the potential to assist and improve ex situ and in situ conservation strategies by storing valuable genetic material. A great deal of studies concerning cryopreservation have been performed within the class Mammalia, although no systematic overview has previously been presented...
February 2018: Zoological Science
https://www.readbyqxmd.com/read/29416198/cytogenetic-abnormalities-found-in-patients-with-reproductive-problems
#6
Mirela Mackic-Djurovic, Sabaheta Hasic, Emina Kiseljakovic, Dunja Rukavina, Slavka Ibrulj
Introduction: One of the important causes of male infertility is aberration at the chromosomes. Aim: The main purpose of this study was to determine the frequency and types of chromosomal aberration in infertile/sterile men whose samples were analyzed in the Center for Cytogenetics of Faculty of Medicine University of Sarajevo in the last four years. Methods: A total of 353 infertile/sterile men, between the ages of 22-55 years, referred for cytogenetic analysis to the Center for Genetics of Faculty of Medicine during the period 2013-2016...
December 2017: Medical Archives
https://www.readbyqxmd.com/read/29409493/scrotal-hemorrhage-after-testicular-sperm-aspiration-may-be-associated-with-phosphodiesterase-5-inhibitor-administration-a-retrospective-study
#7
Yong-Tong Zhu, Rui Hua, Song Quan, Wan-Long Tan, Qing-Jun Chu, Chun-Yan Wang
BACKGROUND: Scrotal hemorrhage after testicular sperm aspiration (TESA) is uncommon in clinical operation. Phosphodiesterase-5 inhibitors (PDE5i) are commonly given to men who have difficulty providing a sperm sample for assisted reproductive technique such as in vitro fertilization. In this study, we examine the incidence of scrotal hemorrhage after TESA in men who received a PDE5i. METHODS: In this retrospective study, 504 men with TESA operation in Center for Reproductive Medicine, Nanfang Hospital, Southern Medical University were collected...
February 6, 2018: BMC Urology
https://www.readbyqxmd.com/read/29409138/treatment-of-semen-samples-with-%C3%AE-chymotrypsin-alters-the-expression-pattern-of-sperm-functional-proteins-a-pilot-study
#8
M K Panner Selvam, A Agarwal, R Sharma, L Samanta
Semen hyperviscosity delays the liquefaction of semen sample and is subjected to limited proteolysis by addition of α-chymotrypsin to reduce the viscosity. α-Chymotrypsin is a proteolytic enzyme involved in degradation of the proteins and polypeptides. Even though α-chymotrypsin improves the handling of hyperviscous samples, its effect on the sperm proteins is not clear. This study was aimed to evaluate the alteration in the expression of sperm functional proteins in samples treated with α-chymotrypsin...
February 6, 2018: Andrology
https://www.readbyqxmd.com/read/29402920/parental-age-and-gene-expression-profiles-in-individual-human-blastocysts
#9
Kiyotaka Kawai, Tatsuya Harada, Tomonori Ishikawa, Rikikazu Sugiyama, Toshihiro Kawamura, Atsumi Yoshida, Osamu Tsutsumi, Fumitoshi Ishino, Toshiro Kubota, Takashi Kohda
The epigenetic status of the genome changes dynamically from fertilization to implantation. In addition, the physiological environment during the process of gametogenesis, including parental age, may affect the epigenome of the embryo after fertilization. It is important to clarify the influence of parental age on gene expression in the embryo in terms of transgenerational epigenetics to improve the techniques currently used in assisted reproductive medicine. Here, we performed single-embryo RNA-seq analysis on human blastocysts fertilized by intracytoplasmic sperm injection, including from relatively elderly mothers, to elucidate the effects of parental age on the embryonic gene expression profile...
February 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29402199/fertility-sparing-treatment-of-adenomyosis-in-patients-with-infertility-a-systematic-review-of-current-options
#10
Tainá Pezzin Rocha, Marina Paula Andres, Giuliano Moysés Borrelli, Mauricio Simões Abrão
Adenomyosis is a benign gynecological disease observed in women in their reproductive age. Recent studies have shown that adenomyosis might be a relevant factor for infertility, either impairing implantation or leading to early miscarriage. However, conservative treatment of infertility related to adenomyosis is still unclear. This study systematically reviews the literature for the reproductive outcomes of the available conservative treatments for patients with adenomyosis-associated infertility. We conducted a search in PubMed/Medline for studies in English published in the last 7 years and included 16 studies...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29397458/how-medical-technologies-shape-the-experience-of-illness
#11
Bjørn Hofmann, Fredrik Svenaeus
In this article we explore how diagnostic and therapeutic technologies shape the lived experiences of illness for patients. By analysing a wide range of examples, we identify six ways that technology can (trans)form the experience of illness (and health). First, technology may create awareness of disease by revealing asymptomatic signs or markers (imaging techniques, blood tests). Second, the technology can reveal risk factors for developing diseases (e.g., high blood pressure or genetic tests that reveal risks of falling ill in the future)...
February 3, 2018: Life Sciences, Society and Policy
https://www.readbyqxmd.com/read/29392515/obstetric-and-neonatal-outcome-following-icsi-with-assisted-oocyte-activation-by-calcium-ionophore-treatment
#12
Ileana Mateizel, Greta Verheyen, Hilde Van de Velde, Herman Tournaye, Florence Belva
PURPOSE: Calcium ionophore treatment is being used in assisted reproductive technology (ART) for cases with previous low fertilization rate or total absence of fertilization after insemination by intracytoplasmic sperm injection or when a specific indication such as globozoospermia is present. As this technique is more invasive and differs from the physiological process of fertilization, a thorough investigation of the health of the children born following this procedure is required. We intent to report the medical outcome of all children conceived following calcium ionophore treatment in our IVF center...
February 1, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29387825/reconstruction-of-mammalian-oocytes-by-germinal-vesicle-transfer-a-systematic-review
#13
REVIEW
Sara Darbandi, Mahsa Darbandi, Hamid Reza Khorram Khorshid, Abolfazl Shirazi, Mohammad Reza Sadeghi, Ashok Agarwal, Safaa Al-Hasani, Mohammad Mehdi Naderi, Ahmet Ayaz, Mohammad Mehdi Akhondi
Nuclear transfer procedures have been recently applied for clinical and research targets as a novel assisted reproductive technique and were used for increasing the oocyte activity during its growth and maturation. In this review, we summarized the nuclear transfer technique for germinal vesicle stage oocytes to reconstruct the maturation of them. Our study covered publications between 1966 and August 2017. In result utilized germinal vesicle transfer techniques, fusion, and fertilization survival rate on five different mammalian species are discussed, regarding their potential clinical application...
October 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29385154/effect-of-maternal-age-on-the-risk-of-preterm-birth-a-large-cohort-study
#14
Florent Fuchs, Barbara Monet, Thierry Ducruet, Nils Chaillet, Francois Audibert
BACKGROUND: Maternal age at pregnancy is increasing worldwide as well as preterm birth. However, the association between prematurity and advanced maternal age remains controversial. OBJECTIVE: To evaluate the impact of maternal age on the occurrence of preterm birth after controlling for multiple known confounders in a large birth cohort. STUDY DESIGN: Retrospective cohort study using data from the QUARISMA study, a large Canadian randomized controlled trial, which collected data from 184,000 births in 32 hospitals...
2018: PloS One
https://www.readbyqxmd.com/read/29379671/fertility-preservation-in-male-patients-subjected-to-chemotherapy-innovative-approaches-for-further-progress
#15
Mohamed Shehata
About 4% of male patients with cancer are under the age of 35 years. With the current increase in efficacy and safety of therapies, a growing number of young adults can achieve long-term survival. In male patients receiving systemic chemotherapy and or bone marrow transplantation, a permanent loss of fertility is a common adverse effect. The only possibility to preserve the patient's fertility is to spare the gametes or gamete-forming cells from the chemotherapeutic effect. In adults, this can be achieved by the cryopreservation of spermatozoa with the subsequent application of assisted reproductive technology...
December 2017: Turkish Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29363374/mood-state-at-the-beginning-of-the-pregnancy-and-its-influence-on-obstetric-and-perinatal-outcomes
#16
Ernesto S González-Mesa, M Luisa Arroyo-González, Nadia Ibrahim-Díez, Olga Cazorla-Granados
AIM: We designed this study to ascertain the prevalence of depressive disorders and anxiety at the beginning of the pregnancy, studying possible associated factors and assessing the influence of mood disorders on perinatal outcomes. METHODS: A representative sample of 191 pregnant women at first trimester of their pregnancies completed a questionnaire that included the Whooley´s questions, the Spanish version of the Beck Depression Inventory (BDI), the State-Trait Anxiety Inventory and a series of questions related to health status, general mood and sociodemographic variables...
January 24, 2018: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29345446/the-first-south-american-case-of-pre-implantation-genetic-diagnosis-to-select-compatible-embryo-for-cord-blood-transplantation-as-treatment-for-sickle-cell-anemia
#17
Ciro D Martinhago, Kalina Rn Endo, Mariana A Oliveira, Alex Mm Dias, Gislaine S Pereira, Augusto M Azzolini, Paula Rq Estrada, Caio G Bruzaca, Ana Carolina N Martinhago
Sickle cell anemia is an inherited systemic hemoglobinopathy that affects hemoglobin production in red blood cells, leading to early morbidity and mortality. It is caused by a homozygous nucleotide substitution (c.20A>T) in the β-globin gene (HBB) that changes a glutamic acid to a valine in the protein. We present a case report of a fertile couple, both carriers of the sickle cell anemia mutation, with one affected daughter. Six cycles of assisted reproductive techniques were performed, resulting in 53 embryos in cleavage stage...
January 18, 2018: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/29343272/biotechnologies-that-empower-transgender-persons-to-self-actualize-as-individuals-partners-spouses-and-parents-are-defining-new-ways-to-conceive-a-child-psychological-considerations-and-ethical-issues
#18
REVIEW
Agnès Condat, Nicolas Mendes, Véronique Drouineaud, Nouria Gründler, Chrystelle Lagrange, Colette Chiland, Jean-Philippe Wolf, François Ansermet, David Cohen
Today, thanks to biomedical technologies advances, some persons with fertility issues can conceive. Transgender persons benefit also from these advances and can not only actualize their self-identified sexual identities but also experience parenthood. Based on clinical multidisciplinary seminars that gathered child psychiatrists and psychoanalysts interested in the fields of assisted reproduction technology (ART) and gender dysphoria, philosophers interested in bioethics, biologists interested in ART, and endocrinologists interested in pubertal suppression, we explore how new biotechnical advances, whether in gender transition or procreation, could create new ways to conceive a child possible...
January 17, 2018: Philosophy, Ethics, and Humanities in Medicine: PEHM
https://www.readbyqxmd.com/read/29339137/oxygen-induced-alterations-in-the-expression-of-chromatin-modifying-enzymes-and-the-transcriptional-regulation-of-imprinted-genes
#19
William M Skiles, Avery Kester, Jane H Pryor, Mark E Westhusin, Michael C Golding, Charles R Long
Embryo culture and assisted reproductive technologies have been associated with a disproportionately high number of epigenetic abnormalities in the resulting offspring. However, the mechanisms by which these techniques influence the epigenome remain poorly defined. In this study, we evaluated the capacity of oxygen concentration to influence the transcriptional control of a selection of key enzymes regulating chromatin structure. In mouse embryonic stem cells, oxygen concentrations modulated the transcriptional regulation of the TET family of enzymes, as well as the de novo methyltransferase Dnmt3a...
January 12, 2018: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/29334209/comparison-of-the-effects-of-vitrification-on-gene-expression-of-mature-mouse-oocytes-using-cryotop-and-open-pulled-straw
#20
Fardin Amidi, Zahra Khodabandeh, Mohamad Hossain Nori Mogahi
Background: Oocyte cryopreservation is an essential part of the assisted reproductive technology (ART), which was recently introduced into clinical practice. This study aimed to evaluate the effects of two vitrification systems-Cryotop and Open Pulled Straw (OPS)-on mature oocytes gene expressions. MATERIALS AND METHODS: In this experimental study, the survival rate of metaphase II (MII) mouse oocytes were assessed after cryopreservation by vitrification via i. OPS or ii...
April 2018: International Journal of Fertility & Sterility
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