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https://www.readbyqxmd.com/read/28522360/sex-with-no-regrets-how-sexual-reproduction-uses-a-no-regret-learning-algorithm-for-evolutionary-advantage
#1
Omer Edhan, Ziv Hellman, Dana Sherill-Rofe
The question of 'why sex' has long been a puzzle. The randomness of recombination, which potentially produces low fitness progeny, contradicts notions of fitness landscape hill climbing. We use the concept of evolution as an algorithm for learning unpredictable environments to provide a possible answer. While sex and asex both implement similar machine learning no-regret algorithms in the context of random samples that are small relative to a vast genotype space, the algorithm of sex constitutes a more efficient goal-directed walk through this space...
May 15, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28521139/global-representations-of-goal-directed-behavior-in-distinct-cell-types-of-mouse-neocortex
#2
William E Allen, Isaac V Kauvar, Michael Z Chen, Ethan B Richman, Samuel J Yang, Ken Chan, Viviana Gradinaru, Benjamin E Deverman, Liqun Luo, Karl Deisseroth
The successful planning and execution of adaptive behaviors in mammals may require long-range coordination of neural networks throughout cerebral cortex. The neuronal implementation of signals that could orchestrate cortex-wide activity remains unclear. Here, we develop and apply methods for cortex-wide Ca(2+) imaging in mice performing decision-making behavior and identify a global cortical representation of task engagement encoded in the activity dynamics of both single cells and superficial neuropil distributed across the majority of dorsal cortex...
May 17, 2017: Neuron
https://www.readbyqxmd.com/read/28521122/ready-steady-go-imaging-cortical-activity-during-movement-planning-and-execution
#3
Arkarup Banerjee, Michael A Long
In this issue of Neuron, Chen et al. (2017) examine premotor activity representing motor planning, Allen et al. (2017) observe the global representation of goal-directed movement on the cortical network, and Makino et al. (2017) track changes in such dynamics throughout learning.
May 17, 2017: Neuron
https://www.readbyqxmd.com/read/28509781/correction-of-severe-coagulopathy-and-hyperfibrinolysis-by-tranexamic-acid-and-recombinant-factor-viia-in-a-cirrhotic-patient-after-trauma-a-case-report
#4
Jack Louro, Katherine Andersen, Roman Dudaryk
Coagulopathy induced by trauma or cirrhosis is a well-recognized entity. Viscoelastic testing has been used in either condition for goal-directed transfusion and detection of fibrinolysis since conventional coagulation tests do not correlate with clinical risk of bleeding. Hemostatic resuscitation may not be adequate for a trauma patient with liver disease due to complex alterations in coagulation systems and occasionally require adjuvant therapy. We report a case of trauma-induced coagulopathy presenting as severe hyperfibrinolysis in a cirrhotic patient who was refractory to hemostatic resuscitation but was rapidly corrected by the administration of tranexamic acid and recombinant Factor VIIa...
May 12, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28504410/unpacking-the-ontogeny-of-gesture-understanding-how-movement-becomes-meaningful-across-development
#5
Elizabeth M Wakefield, Miriam A Novack, Susan Goldin-Meadow
Gestures, hand movements that accompany speech, affect children's learning, memory, and thinking (e.g., Goldin-Meadow, 2003). However, it remains unknown how children distinguish gestures from other kinds of actions. In this study, 4- to 9-year-olds (n = 339) and adults (n = 50) described one of three scenes: (a) an actor moving objects, (b) an actor moving her hands in the presence of objects (but not touching them), or (c) an actor moving her hands in the absence of objects. Participants across all ages were equally able to identify actions on objects as goal directed, but the ability to identify empty-handed movements as representational actions (i...
May 15, 2017: Child Development
https://www.readbyqxmd.com/read/28503840/a-critical-note-on-treatment-of-a-severe-diltiazem-intoxication-high-dose-calcium-and-glucagon-infusions
#6
N M Van Veggel, G J Van der Veen, T C Jansen, E M Westerman
The morbidity and mortality of a severe calcium channel blocker intoxication is high due to serious toxic cardiac effects. Its treatment is supported by low-quality evidence from heterogeneous literature. We describe a case of a severe diltiazem intoxication and critically appraise the efficacy and role of high-dose calcium and glucagon infusions. A 53-year-old woman was admitted to the emergency department with a cardiogenic shock with complete AV block, not responding to atropine, isoprenaline and an external pacemaker...
May 15, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28501732/asymmetrical-stabilization-and-mobilization-exploited-during-static-single-leg-stance-and-goal-directed-kicking
#7
Adam C King, Zheng Wang
The motor control properties of the right and left legs are dependent on the stabilization and mobilization features of the motor tasks. The current investigation examined the right and left leg control differences - interlateral asymmetries - during static single leg stance and dynamic goal directed kicking with an emphasis of the asymmetrical stabilization and mobilization components of movements. Ten young, healthy, right-leg preferred individuals with minimal kicking experience completed both tests on each limb...
May 11, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28501632/high-levels-of-maternally-transferred-mercury-disrupt-magnetic-responses-of-snapping-turtle-hatchlings-chelydra-serpentina
#8
Lukas Landler, Michael S Painter, Brittney Hopkins Coe, Paul W Youmans, William A Hopkins, John B Phillips
The Earth's magnetic field is involved in spatial behaviours ranging from long-distance migration to non-goal directed behaviours, such as spontaneous magnetic alignment (SMA). Mercury is a harmful pollutant most often generated from anthropogenic sources that can bio-accumulate in animal tissue over a lifetime. We compared SMA of hatchling snapping turtles from mothers captured at reference (i.e., low mercury) and mercury contaminated sites. Reference turtles showed radio frequency-dependent SMA along the north-south axis, consistent with previous studies of SMA, while turtles with high levels of maternally inherited mercury failed to show consistent magnetic alignment...
May 11, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28501337/late-in-hospital-management-of-patients-hospitalized-with-acute-heart-failure
#9
REVIEW
Nicole B Cyrille, Snehal R Patel
Acute Heart Failure (AHF) hospitalization presents a significant financial burden and portends a poor prognosis following discharge. As such, there has been significant emphasis on the late inpatient management of patients hospitalized with AHF to ensure successful transition to the outpatient setting and to reduce overall readmission and mortality rates. Thorough discharge planning and a multidisciplinary team approach are essential and as outlined in this review should focus on four key elements: the assessment of patients' readiness for discharge, optimization of goal directed medical therapy and appropriate device therapy, patient education and transition to the outpatient care...
May 10, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/28500653/blood-transfusion-in-the-surgical-treatment-of-adolescent-idiopathic-scoliosis-a-single-center-experience-of-patient-blood-management-in-210-cases
#10
Søren Ohrt-Nissen, Naeem Bukhari, Casper Dragsted, Martin Gehrchen, Pär I Johansson, Jesper Dirks, Jakob Stensballe, Benny Dahl
BACKGROUND: The surgical treatment of adolescent idiopathic scoliosis can be associated with substantial blood loss, requiring allogeneic red blood cell (RBC) transfusion. This study describes the use of RBC and the effect of a standardized perioperative patient blood management program. STUDY DESIGN AND METHODS: Patients treated with posterior instrumented fusion were consecutively enrolled over a 6-year period. Patient blood management strategies were implemented in 2011, including prophylactic tranexamic acid, intraoperative permissive hypotension, restrictive fluid therapy (including avoidance of synthetic colloids), restrictive RBC trigger according to institutional standardized protocol, the use of cell savage, and goal-directed therapy according to thrombelastography...
May 12, 2017: Transfusion
https://www.readbyqxmd.com/read/28500456/sex-differences-in-spatial-accuracy-relate-to-the-neural-activation-of-antagonistic-muscles-in-young-adults
#11
Agostina Casamento-Moran, Sandra K Hunter, Yen-Ting Chen, Min Hyuk Kwon, Emily J Fox, Basma Yacoubi, Evangelos A Christou
Sex is an important physiological variable of behavior, but its effect on motor control remains poorly understood. Some evidence suggests that women exhibit greater variability during constant contractions and poorer accuracy during goal-directed tasks. However, it remains unclear whether motor output variability or altered muscle activation impairs accuracy in women. Here, we examine sex differences in endpoint accuracy during ankle goal-directed movements and the activity of the antagonistic muscles. Ten women (23...
May 12, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28499991/an-interactive-simulator-for-imposing-virtual-musculoskeletal-dynamics
#12
Christopher Hasson
OBJECTIVE: Disease processes are often marked by both neural and muscular changes that alter movement control and execution, but these adaptations are difficult to tease apart because they occur simultaneously. This is addressed by swapping an individual's limb dynamics with a neurally-controlled facsimile using an interactive musculoskeletal simulator (IMS) that allows controlled modifications of musculoskeletal dynamics. This paper details the design and operation of the IMS, quantifies and describes human adaptation to the IMS, and determines whether the IMS allows users to move naturally, a prerequisite for manipulation experiments...
May 10, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28499987/evoked-potentials-in-final-epoch-of-self-initiated-hand-movement-a-study-in-patients-with-depth-electrodes
#13
Miloslav Kukleta, Alena Damborská, Baris Turak, Jacques Louvel
Comparison between the intended and performed motor action can be expected to occur in the final epoch of a voluntary movement. In search for electrophysiological correlates of this mental process the purpose of the current study was to identify intracerebral sites activated in final epoch of self-paced voluntary movement. Intracerebral EEG was recorded from 235 brain regions of 42 epileptic patients who performed self-paced voluntary movement task. Evoked potentials starting at 0 to 243ms after the peak of averaged, rectified electromyogram were identified in 21 regions of 13 subjects...
May 10, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28499145/human-dorsomedial-parieto-motor-circuit-specifies-grasp-during-the-planning-of-goal-directed-hand-actions
#14
Michael Vesia, Michael Barnett-Cowan, Behzad Elahi, Gaayathiri Jegatheeswaran, Reina Isayama, Jason L Neva, Marco Davare, W Richard Staines, Jody C Culham, Robert Chen
According to one influential view, two specialized parieto-frontal circuits control prehension: a dorsomedial stream for hand transport during reaching and a dorsolateral stream for preshaping the fingers during grasping. However, recent evidence argues that an area within the dorsomedial stream-macaque area V6A and, its putative human homolog, superior parietal occipital cortex (SPOC) - encodes both hand transport and grip formation. We tested whether planning varied hand actions modulates functional connectivity between left SPOC and ipsilateral primary motor cortex (M1) using a dual-site, paired-pulse transcranial magnetic stimulation paradigm with two coils (dsTMS)...
April 19, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28497379/-choosing-wisely-recommendations-in-cardiology
#15
REVIEW
K Werdan, S Baldus, N Frey, U Nixdorff, K-H Kuck, H Katus
This article describes controversially discussed Choosing wisely recommendations presented by the German Cardiac Society: anticoagulation therapy in patients with atrial fibrillation and "only" moderate stroke risk, on the one hand, and goal-directed low-density lipoprotein (LDL) cholesterol-lowering, on the other. Presuming an adequate regime, patients with atrial fibrillation and only moderate risk of stroke (CHA2DS2-VASc Score of 1 in men and of 2 in women) also benefit from anticoagulation therapy, even in elderly patients...
May 11, 2017: Der Internist
https://www.readbyqxmd.com/read/28496402/cortico-striatal-thalamic-loop-circuits-of-the-orbitofrontal-cortex-promising-therapeutic-targets-in-psychiatric-illness
#16
REVIEW
Peter Fettes, Laura Schulze, Jonathan Downar
Corticostriatal circuits through the orbitofrontal cortex (OFC) play key roles in complex human behaviors such as evaluation, affect regulation and reward-based decision-making. Importantly, the medial and lateral OFC (mOFC and lOFC) circuits have functionally and anatomically distinct connectivity profiles which differentially contribute to the various aspects of goal-directed behavior. OFC corticostriatal circuits have been consistently implicated across a wide range of psychiatric disorders, including major depressive disorder (MDD), obsessive compulsive disorder (OCD), and substance use disorders (SUDs)...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28489712/maximizing-surgical-skills-during-fellowship-training
#17
Brian Shiu, Djuro Petkovic, William N Levine, Christopher S Ahmad
Orthopaedic surgery fellowship provides an opportunity to further develop skills in a particular subspecialty. However, the condensed time frame, complex skill acquisition, and clinical demands require efficient and effective learning techniques to achieve mastery. As with any advanced task, success during fellowship training can be achieved with active participation and a goal-directed approach. Skill acquisition can be successfully achieved by following a framework that includes preparation, execution, and reflection for every surgical case...
June 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28487563/neural-correlates-of-distraction-and-conflict-resolution-for-nonverbal-auditory-events
#18
Hannah J Stewart, Sygal Amitay, Claude Alain
In everyday situations auditory selective attention requires listeners to suppress task-irrelevant stimuli and to resolve conflicting information in order to make appropriate goal-directed decisions. Traditionally, these two processes (i.e. distractor suppression and conflict resolution) have been studied separately. In the present study we measured neuroelectric activity while participants performed a new paradigm in which both processes are quantified. In separate block of trials, participants indicate whether two sequential tones share the same pitch or location depending on the block's instruction...
May 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28486594/apathy-and-impulsivity-in-frontotemporal-lobar-degeneration-syndromes
#19
Claire J Lansdall, Ian T S Coyle-Gilchrist, P Simon Jones, Patricia Vázquez Rodríguez, Alicia Wilcox, Eileen Wehmann, Katrina M Dick, Trevor W Robbins, James B Rowe
Apathy and impulsivity are common and disabling consequences of frontotemporal lobar degeneration. They cause substantial carer distress, but their aetiology remains elusive. There are critical limitations to previous studies in this area including (i) the assessment of either apathy or impulsivity alone, despite their frequent co-existence; (ii) the assessment of behavioural changes within single diagnostic groups; and (iii) the use of limited sets of tasks or questions that relate to just one aspect of these multifactorial constructs...
May 9, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28485884/altered-sensorimotor-cortical-oscillations-in-individuals-with-multiple-sclerosis-suggests-a-faulty-internal-model
#20
David J Arpin, Elizabeth Heinrichs-Graham, James E Gehringer, Rana Zabad, Tony W Wilson, Max J Kurz
Multiple sclerosis (MS) is a demyelinating disease that results in a broad array of symptoms, including impaired motor performance. How such demyelination of fibers affects the inherent neurophysiological activity in motor circuits, however, remains largely unknown. Potentially, the movement errors associated with MS may be due to imperfections in the internal model used to make predictions of the motor output that will meet the task demands. Prior magnetoencephalographic (MEG) and electroencephalographic brain imaging experiments have established that the beta (15-30 Hz) oscillatory activity in the sensorimotor cortices is related to the control of movement...
May 9, 2017: Human Brain Mapping
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