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https://www.readbyqxmd.com/read/29224406/novel-psychotherapeutics-a-cautiously-optimistic-focus-on-hallucinogens
#1
Alexander M Sherwood, Thomas E Prisinzano
No abstract text is available yet for this article.
December 11, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/29221792/the-serotonin-hallucinogen-5-meo-dmt-alters-cortico-thalamic-activity-in-freely-moving-mice-regionally-selective-involvement-of-5-ht1a-and-5-ht2a-receptors
#2
REVIEW
Maurizio S Riga, Laia Lladó-Pelfort, Francesc Artigas, Pau Celada
5-MeO-DMT is a natural hallucinogen acting as serotonin 5-HT1A/5-HT2A receptor agonist. Its ability to evoke hallucinations could be used to study the neurobiology of psychotic symptoms and to identify new treatment targets. Moreover, recent studies revealed the therapeutic potential of serotonin hallucinogens in treating mood and anxiety disorders. Our previous results in anesthetized animals show that 5-MeO-DMT alters cortical activity via 5-HT1A and 5-HT2A receptors. Here, we examined 5-MeO-DMT effects on oscillatory activity in prefrontal (PFC) and visual (V1) cortices, and in mediodorsal thalamus (MD) of freely-moving wild-type (WT) and 5-HT2A-R knockout (KO2A) mice...
December 5, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29216523/use-of-synthetic-stimulants-and-hallucinogens-in-a-cohort-of-electronic-dance-music-festival-attendees
#3
Amanda L A Mohr, Melissa Friscia, Jillian K Yeakel, Barry K Logan
Novel psychoactive substances (NPS), often characterized as unregulated psychoactive compounds designed to circumvent existing legislation, have become mainstream on the illicit drug market. Because of their physical and mind-altering properties, NPS may be deliberately or inadvertently ingested at electronic dance music (EDM) festivals to enhance the attendees' appreciation of the music and overall experience. Their widespread use at EDM festivals have been well documented and several adverse events and fatalities associated with NPS ingestion have been reported in the United States...
November 21, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29209235/the-endless-trip-among-the-nps-users-psychopathology-and-psychopharmacology-in-the-hallucinogen-persisting-perception-disorder-a-systematic-review
#4
REVIEW
Laura Orsolini, Gabriele Duccio Papanti, Domenico De Berardis, Amira Guirguis, John Martin Corkery, Fabrizio Schifano
Hallucinogen-persisting perception disorder (HPPD) is a syndrome characterized by prolonged or reoccurring perceptual symptoms, reminiscent of acute hallucinogen effects. HPPD was associated with a broader range of LSD (lysergic acid diethylamide)-like substances, cannabis, methylenedioxymethamphetamine (MDMA), psilocybin, mescaline, and psychostimulants. The recent emergence of novel psychoactive substances (NPS) posed a critical concern regarding the new onset of psychiatric symptoms/syndromes, including cases of HPPD...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29199899/alcohol-and-drug-use-pain-and-psychiatric-symptoms-among-adults-seeking-outpatient-psychiatric-treatment-latent-class-patterns-and-relationship-to-health-status
#5
Danielle E Ramo, Amber L Bahorik, Kevin L Delucchi, Cynthia I Campbell, Derek D Satre
BACKGROUND: Substance use, psychiatric problems, and pain frequently co-occur, yet clinical profiles of treatment-seeking patients are poorly understood. To inform service and treatment planning, substance use and symptom patterns were examined in an outpatient psychiatry clinic, along with the relationship of these patterns to demographic characteristics and physical health. METHODS: Patients (N = 405; age M = 38; 69% White; 60% female) presenting for intake in a psychiatry outpatient clinic completed a computerized assessment of psychiatric problems, drinking, and drug use...
December 4, 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/29189143/retrospective-demonstration-of-25i-nbome-acute-poisoning-using-hair-analysis
#6
Alice Ameline, Audrey Farrugia, Jean-Sebastien Raul, Pascal Kintz
BACKGROUND: The abuse of new psychoactive substances or NPS has been dramatically increasing all around the world since the late 2000s and has become a serious public health problem. NPS are a challenge for the worldwide forensic community due to the difficulties to accurately document the cases. The N-benzylmethoxy (NBOMe) group is a new class of hallucinogenic designer drugs and has gained importance in the recent years. 25I-NBOMe (2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine) is an analog of the 2C series of psychedelic phenethylamine drugs that contain an N-methoxybenzyl substituent, which significantly affects their pharmacological activities...
November 29, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29180224/a-regulatory-perspective-on-the-evaluation-of-hallucinogen-drugs-for-human-use
#7
REVIEW
Silvia N Calderon, Joshua Hunt, Michael Klein
In the recent years, there is renewed interest in the study of various hallucinogens for their potential therapeutic effects. In the United States of America (USA), the abuse potential assessment of a drug is carried out as part of the general safety and efficacy evaluation of a drug. Additionally, the abuse potential assessment is taken under consideration in determining if a drug needs to be subject to controls to minimize the abuse of the drug once on the market. This assessment is conducted for all new drugs with central nervous system (CNS) activity, that are chemically or pharmacologically similar to other drugs with known abuse potential, or drugs that produce psychoactive effects predictive of abuse, such as euphoria and hallucinations...
November 24, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29162429/studies-with-psychedelic-drugs-in-human-volunteers
#8
REVIEW
Edward M Sellers, Myroslava K Romach, Deborah B Leiderman
Scientific curiosity and fascination have played a key role in human research with psychedelics along with the hope that perceptual alterations and heightened insight could benefit well-being and play a role in the treatment of various neuropsychiatric disorders. These motivations need to be tempered by a realistic assessment of the hurdles to be cleared for therapeutic use. Development of a psychedelic drug for treatment of a serious psychiatric disorder presents substantial although not insurmountable challenges...
November 18, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29147729/regulation-of-human-research-with-lsd-in-the-united-states-1949-1987
#9
REVIEW
Katherine R Bonson
Human research with hallucinogens such as lysergic acid diethylamide (LSD) has been ongoing in the USA since 1949. During the 1960s, LSD was investigated for a variety of psychiatric indications, including the following: as an aid in treatment of schizophrenia; as a means of creating a "model psychosis"; as a direct antidepressant; and as an adjunct to psychotherapy. Studies with all drugs, including LSD, have always been conducted under federal regulatory controls, including the 1938 Food Drug and Cosmetic Act (FDCA; which ensured the safety of drugs) and the 1962 Kefauver-Harris Amendments to the FDCA (which described appropriate scientific methodology and ensured drug efficacy)...
November 17, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29120851/the-generalizability-of-the-structure-of-substance-abuse-and-antisocial-behavioral-syndromes-a-systematic-review
#10
REVIEW
S E Soe-Agnie, M C S Paap, J E L VanDerNagel, H J M Nijman, C A J de Jong
BACKGROUND: Although several authors have suggested that a single externalizing spectrum encompassing both antisocial behavioral syndromes and substance use disorder is to be preferred, this assumption has not been evaluated systematically throughout studies. PURPOSE: The objective was to establish the generalizability of transdiagnostic models of externalizing disorders across different types of disorders and populations, in regard to the strength of the evidence...
November 4, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29118576/psychosocial-therapy-for-parkinson-s-related-dementia-intervention-development
#11
Sheree A McCormick, Kathryn R McDonald, Sabina Vatter, Vasiliki Orgeta, Ellen Poliakoff, Sarah J Smith, Iracema Leroi
Background: Group-based psychosocial therapy, such as group Cognitive Stimulation Therapy, improves cognition and quality of life in people living with dementia. Neuropsychiatric symptoms and restricted mobility are common complications for people with Parkinson's-related dementia (PRD) and may limit access to, and participation in, group activities. This study describes the development of a condition-specific, home-based psychosocial therapy for people with PRD ready to be trialled in a clinical population...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29116367/double-blind-comparison-of-the-two-hallucinogens-psilocybin-and-dextromethorphan-similarities-and-differences-in-subjective-experiences
#12
Theresa M Carbonaro, Matthew W Johnson, Ethan Hurwitz, Roland R Griffiths
RATIONALE: Although psilocybin and dextromethorphan (DXM) are hallucinogens, they have different receptor mechanisms of action and have not been directly compared. OBJECTIVE: This study compared subjective, behavioral, and physiological effects of psilocybin and dextromethorphan under conditions that minimized expectancy effects. METHODS: Single, acute oral doses of psilocybin (10, 20, 30 mg/70 kg), DXM (400 mg/70 kg), and placebo were administered under double-blind conditions to 20 healthy participants with histories of hallucinogen use...
November 7, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29097307/effect-fingerprinting-of-new-psychoactive-substances-nps-what-can-we-learn-from-in-vitro-data
#13
REVIEW
Laura Hondebrink, Anne Zwartsen, Remco H S Westerink
The use of new psychoactive substances (NPS) is increasing and currently >600 NPS have been reported. However, limited information on neuropharmacological and toxicological effects of NPS is available, hampering risk characterization. We reviewed the literature on the in vitro neuronal modes of action to obtain effect fingerprints of different classes of illicit drugs and NPS. The most frequently reported NPS were selected for review: cathinones (MDPV, α-PVP, mephedrone, 4-MEC, pentedrone, methylone), cannabinoids (JWH-018), (hallucinogenic) phenethylamines (4-fluoroamphetamine, benzofurans (5-APB, 6-APB), 2C-B, NBOMes (25B-NBOMe, 25C-NBOMe, 25I-NBOMe)), arylcyclohexylamines (methoxetamine) and piperazine derivatives (mCCP, TFMPP, BZP)...
October 30, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29057388/overlapping-risky-decision-making-and-olfactory-processing-ability-in-hiv-infected-individuals
#14
Christopher Jackson, Narayan Rai, Charlee K McLean, Maria Mananita S Hipolito, Flora Terrell Hamilton, Suad Kapetanovic, Evaristus A Nwulia
OBJECTIVE: Given neuroimaging evidences of overlap in the circuitries for decision-making and olfactory processing, we examined the hypothesis that impairment in psychophysical tasks of olfaction would independently predict poor performances on Iowa Gambling Task (IGT), a laboratory task that closely mimics real-life decision-making, in a US cohort of HIV-infected (HIV+) individuals. METHOD: IGT and psychophysical tasks of olfaction were administered to a Washington DC-based cohort of largely African American HIV+ subjects (N=100), and to a small number of demographically-matched non-HIV healthy controls (N=43) from a different study...
September 2017: Clinical and Experimental Psychology
https://www.readbyqxmd.com/read/29045249/inhaled-loxapine-for-agitation-in-intoxicated-patients-a-case-series
#15
Carlos Roncero, Elena Ros-Cucurull, Raúl Felipe Palma-Álvarez, Alfonso Carlos Abad, Christian Fadeuilhe, Miquel Casas, Lara Grau-López
OBJECTIVES: Episodes of agitation are frequent in intoxicated patients who have a substance use disorder, a psychiatric disorder or both (dual diagnosis). For managing the agitation, it is necessary to act promptly in a safe environment and addressing any underlying etiology. Inhaled loxapine improves symptoms of agitation in adults with psychiatric disorders (eg, schizophrenia) within 10 minutes of administration. Recently, some reports have documented the usefulness of loxapine in dual diagnoses patients with agitation...
November 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28987938/tcb-2-7r-3-bromo-2-5-dimethoxy-bicyclo-4-2-0-octa-1-3-5-trien-7-yl-methanamine-a-hallucinogenic-drug-a-selective-5-ht2a-receptor-pharmacological-tool-or-none-of-the-above
#16
REVIEW
Giuseppe Di Giovanni, Philippe De Deurwaerdère
The development of 5-HT2A receptor agonists has been considerably marginalized since the demonstration that the tryptaminergic drugs, LSD and psilocybin, or the phenylakylamine drugs, mescaline and DOI, exert their hallucinogenic properties via the stimulation of 5-HT2A receptors. Nonetheless, the ability of drugs to stimulate 5-HT2A receptors is not necessarily associated with psychedelic experience and the hallucinogenic properties are still not understood. Several studies have increased interest in stimulating 5-HT2A receptors in various CNS diseases...
October 4, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28956316/anesthetic-implications-of-recreational-drug-use
#17
Pierre Beaulieu
PURPOSE: As the use of recreational drugs increases, the likelihood of an anesthesiologist perioperatively encountering patients using or addicted to these drugs will also increase. PRINCIPAL FINDINGS: Addicted patients may present for anesthetic care in a variety of circumstances in everyday elective surgeries or in acute or life-saving situations, such as emergency Cesarean delivery or trauma surgery. Therefore, it is important for anesthesiologists to know about the most common illicit drugs being used, their clinical presentation and side effects, and the anesthetic options that are beneficial or detrimental to these patients...
September 27, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28954366/-research-on-hallucinogenic-drugs-used-in-shaman-religious-activities
#18
X Y Fang, P F Fei, J P Zhu, B Yuan
The development of medicine experienced a long history, and the origin of medicine is not appeared overnight. Due to the lack of historical data, the question of the origin of medicine has not been agreed upon. As an ancient primitive religion, Shamanism retains the use of hallucinogenic drugs in its early religious activities rather well, providing a guidance for exploring the cognition on drugs in early human. Through the review of the hallucinogenic plants used by shaman religious activities in different countries and areas, it was found that hallucinogenic drugs can be classified into two categories: single and mixed, which came mainly from plants and fungi, and the origin of hallucinogenic drugs has a high fitting degree with Shaman location...
July 28, 2017: Zhonghua Yi Shi za Zhi, Chinese Journal of Medical History
https://www.readbyqxmd.com/read/28949320/-bunanje-xx-century-abuse-of-atropa-belladonna-halucinogenic-berries-in-continental-croatia
#19
Zdravko Lacković
BACKGROUND: Atropa belladonna (Engl. deadly nightshade, Cro. velebilje, bunika) is a plant containing pharmacologically active, potentially toxic alkaloids: atropine, hyocyamine and scopolamine. The risk of poisoning in children is important because of possible confusion of black/dark blue belladonna fruit berries with other edible berries. There are many reports in literature of accidental intoxication but no report on traditional intentional usage to achieve hallucinogenic effects. SUBJECTS AND METHODS: Here we report purposeful ingestion of Atropa belladonna berries for hallucinatory effects among adolescents in Bjelovar region in north part of Croatia...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28948056/could-hallucinogens-induce-permanent-pupillary-changes-in-ab-users-a-case-report-from-new-zealand
#20
Ahmed Al-Imam
An eighteen-year-old female patient of the Caucasian ethnicity from Australasia presented with a persistently dilated pupil causing her discomfort and occasional burning sensation when she is outdoors due to oversensitivity to sunlight. However, her pupillary reaction to light (pupillary light reflex) was intact. The patient is a known user of psychedelic substances (entheogens) including LSD, NBOMe, psilocybin, and DMT. The condition affects both eyes to the same extent. Thorough medical, neurological, and radiological examinations, including an EEG and an MRI of the head and neck region, were completely normal...
2017: Case Reports in Neurological Medicine
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