Vera Labitzky, Anke Baranowsky, Hanna Maar, Sandra Hanika, Sarah Starzonek, Ann-Kristin Ahlers, Katrin Stübke, Eva J Koziolek, Markus Heine, Paula Schäfer, Sabine Windhorst, Manfred Jücker, Kristoffer Riecken, Michael Amling, Thorsten Schinke, Udo Schumacher, Ursula Valentiner, Tobias Lange
The majority of cancer-related deaths are due to hematogenous metastases, and the bone marrow (BM) represents one of the most frequent metastatic sites. To study BM metastasis formation in vivo, the most efficient approach is based on intracardiac injection of human tumor cells into immunodeficient mice. However, such a procedure circumvents the early steps of the metastatic cascade. Here we describe the development of xenograft mouse models (balb/c rag2 -/- and severe combined immunodeficient (SCID)), in which BM metastases are spontaneously derived from subcutaneous (s...
February 7, 2020: Cancers