keyword
Keywords Bone metastasis, neuroblastoma...

Bone metastasis, neuroblastoma, cancer

https://read.qxmd.com/read/36176417/pro-metastatic-and-mesenchymal-gene-expression-signatures-characterize-circulating-tumor-cells-of-neuroblastoma-patients-with-bone-marrow-metastases-and-relapse
#21
JOURNAL ARTICLE
Amos H P Loh, Clara Angelina, Meng Kang Wong, Sheng Hui Tan, Sarvesh A Sukhatme, Trifanny Yeo, Su Bin Lim, York Tien Lee, Shui Yen Soh, Wing Leung, Kenneth T E Chang, Yong Wei Chua, Syed M F Alkaff, Tony K H Lim, Chwee Teck Lim, Zhi Xiong Chen
Existing marker-based methods of minimal residual disease (MRD) determination in neuroblastoma do not effectively enrich for the circulating disease cell population. Given the relative size differential of neuroblastoma tumor cells over normal hematogenous cells, we hypothesized that cell size-based separation could enrich circulating tumor cells (CTCs) from blood samples and disseminated tumor cells (DTCs) from bone marrow aspirates (BMA) of neuroblastoma patients, and that their gene expression profiles could vary dynamically with various disease states over the course of treatment...
2022: Frontiers in Oncology
https://read.qxmd.com/read/35137546/mycn-amplification-plus-1p36-loss-of-heterozygosity-predicts-ultra-high-risk-in-bone-marrow-metastatic-neuroblastoma
#22
JOURNAL ARTICLE
Zhi-Xia Yue, Tian-Yu Xing, Wen Zhao, Qian Zhao, Xi-Si Wang, Yan Su, Chao Gao, Shu-Guang Liu, Xiao-Li Ma
BACKGROUND: This study aimed to better understand the prognostic effect of multiple genetic markers and identify more subpopulations at ultra high risk of poor outcome in bone marrow (BM) metastatic neuroblastoma (NB). METHODS: We screened the MYCN, 1p36 and 11q23 loss of heterozygosity (LOH) statuses of 154 patients by interphase fluorescence in situ hybridization of BM cells. The clinical characteristics of patients with the three markers and their associations with prognosis were analysed...
April 2022: Cancer Medicine
https://read.qxmd.com/read/35023974/factors-of-recurrence-after-complete-response-in-children-with-neuroblastoma-a-16-year-retrospective-study-of-179-cases
#23
JOURNAL ARTICLE
Fan Li, Weiling Zhang, Huimin Hu, Yi Zhang, Jing Li, Dongsheng Huang
BACKGROUND: It is not clear which known adverse prognostic factors of neuroblastoma are closely associated with tumor recurrence after complete response. We analyzed the factors for post-remission recurrence in children with neuroblastoma through a retrospective study. METHODS: A total of 179 children with neuroblastoma who achieved initial complete response were included in this study. Kaplan-Meier method and multivariate Cox regression model were used to assess the factors that may have impact on tumor recurrence after complete response...
2022: Cancer Management and Research
https://read.qxmd.com/read/34853141/metastatic-4s-neuroblastoma-with-excellent-outcome-in-saudi-cancer-center
#24
JOURNAL ARTICLE
Waheed A AlZhrani, Naglla A Elimam, Abeer S Almehdar, Saeed M Bassem, Daniah E Abdullatif, Khursheed D Ahmed, Abdullah A Baothman
OBJECTIVES: To retrospectively review a small series of infant neuroblastoma (NBL) in a single Saudi medical institution over 10 years, including their presentation, management, and outcomes. METHODS: Fifty-three subjects aged 0 to 14 years with previously untreated NBL who were diagnosed and treated at Princess Nora Oncology Center, King Abdulaziz Medical City (KAMC), Jeddah, Saudi Arabia, between 2010 and 2019. Six infants (11.3%) had stage 4S characteristics...
December 2021: Saudi Medical Journal
https://read.qxmd.com/read/34831167/mechanisms-diagnosis-and-treatment-of-bone-metastases
#25
REVIEW
Jozef Ban, Valerie Fock, Dave N T Aryee, Heinrich Kovar
Bone and bone marrow are among the most frequent metastatic sites of cancer. The occurrence of bone metastasis is frequently associated with a dismal disease outcome. The prevention and therapy of bone metastases is a priority in the treatment of cancer patients. However, current therapeutic options for patients with bone metastatic disease are limited in efficacy and associated with increased morbidity. Therefore, most current therapies are mainly palliative in nature. A better understanding of the underlying molecular pathways of the bone metastatic process is warranted to develop novel, well-tolerated and more successful treatments for a significant improvement of patients' quality of life and disease outcome...
October 29, 2021: Cells
https://read.qxmd.com/read/34798079/musculoskeletal-diagnoses-before-cancer-in-children-a-danish-registry-based-cohort-study
#26
JOURNAL ARTICLE
Ninna Brix, Jesper Amstrup, Mette Nørgaard, Søren Hagstrøm, Henrik Hasle, Troels Herlin
OBJECTIVE: To identify the prevalence of musculoskeletal diagnoses recorded 6 months before the diagnosis of cancer and to evaluate whether preceding musculoskeletal diagnoses affected survival. STUDY DESIGN: We performed a nationwide registry-based cohort study including all children under 15 years of age diagnosed with cancer in Denmark over a 23-year period (1996-2018). The Danish National Patient Registry was used to identify musculoskeletal diagnoses and associated dates recorded within 6 months preceding the diagnosis of cancer...
March 2022: Journal of Pediatrics
https://read.qxmd.com/read/34789839/chd5-inhibits-metastasis-of-neuroblastoma
#27
JOURNAL ARTICLE
Astrid K Laut, Carmen Dorneburg, Axel Fürstberger, Thomas F E Barth, Hans A Kestler, Klaus-Michael Debatin, Christian Beltinger
CHD5, a tumor suppressor at 1p36, is frequently lost or silenced in poor prognosis neuroblastoma (NB) and many adult cancers. The role of CHD5 in metastasis is unknown. We confirm that low expression of CHD5 is associated with stage 4 NB. Forced expression of CHD5 in NB cell lines with 1p loss inhibited key aspects of the metastatic cascade in vitro: anchorage-independent growth, migration, and invasion. In vivo, formation of bone marrow and liver metastases developing from intravenously injected NB cells was delayed and decreased by forced CHD5 expression...
January 2022: Oncogene
https://read.qxmd.com/read/34503120/landscape-of-bone-marrow-metastasis-in-human-neuroblastoma-unraveled-by-transcriptomics-and-deep-multiplex-imaging
#28
JOURNAL ARTICLE
Daria Lazic, Florian Kromp, Fikret Rifatbegovic, Peter Repiscak, Michael Kirr, Filip Mivalt, Florian Halbritter, Marie Bernkopf, Andrea Bileck, Marek Ussowicz, Inge M Ambros, Peter F Ambros, Christopher Gerner, Ruth Ladenstein, Christian Ostalecki, Sabine Taschner-Mandl
While the bone marrow attracts tumor cells in many solid cancers leading to poor outcome in affected patients, comprehensive analyses of bone marrow metastases have not been performed on a single-cell level. We here set out to capture tumor heterogeneity and unravel microenvironmental changes in neuroblastoma, a solid cancer with bone marrow involvement. To this end, we employed a multi-omics data mining approach to define a multiplex imaging panel and developed DeepFLEX, a pipeline for subsequent multiplex image analysis, whereby we constructed a single-cell atlas of over 35,000 disseminated tumor cells (DTCs) and cells of their microenvironment in the metastatic bone marrow niche...
August 26, 2021: Cancers
https://read.qxmd.com/read/34218225/conservation-of-epithelial-to-mesenchymal-transition-process-in-neural-crest-cells-and-metastatic-cancer
#29
JOURNAL ARTICLE
April Zhang, Hira Aslam, Neha Sharma, Aryeh Warmflash, Walid D Fakhouri
Epithelial to mesenchymal transition (EMT) is a highly conserved cellular process in several species, from worms to humans. EMT plays a fundamental role in early embryogenesis, wound healing, and cancer metastasis. For neural crest cell (NCC) development, EMT typically results in forming a migratory and potent cell population that generates a wide variety of cell and tissue, including cartilage, bone, connective tissue, endocrine cells, neurons, and glia amongst many others. The degree of conservation between the signaling pathways that regulate EMT during development and metastatic cancer (MC) has not been fully established, despite ample studies...
2021: Cells, Tissues, Organs
https://read.qxmd.com/read/34141621/clinical-characteristics-and-survival-outcomes-in-neuroblastoma-with-bone-metastasis-based-on-seer-database-analysis
#30
JOURNAL ARTICLE
Bin He, Jianshui Mao, Leyi Huang
PURPOSE: Clinical features and survival analysis of neuroblastoma (NB) are well explored. However, clinical research of NB patients with bone metastasis is rarely reported. Thus, the current study was performed to analyze the clinical features, survival outcome, and risk factors in those patients. MATERIALS AND METHODS: We reviewed the Surveillance, Epidemiology, and End Results (SEER) database to select cases diagnosed with NB with bone metastasis from 2010 to 2016...
2021: Frontiers in Oncology
https://read.qxmd.com/read/34108028/chromosome-10-abnormality-predicts-prognosis-of-neuroblastoma-patients-with-bone-marrow-metastasis
#31
JOURNAL ARTICLE
Chi-Yi Jiang, Xiao Xu, Bing-Lin Jian, Xue Zhang, Zhi-Xia Yue, Wei Guo, Xiao-Li Ma
BACKGROUND: Neuroblastoma (NB) is the most common extracranial solid tumor in children. It is known for high heterogeneity and concealed onset. In recent years, the mechanism of its occurrence and development has been gradually revealed. The purpose of this study is to summarize the clinical characteristics of children with NB and abnormal chromosome 10, and to investigate the relationship between the number and structure of chromosome 10 abnormalities and NB prognosis. METHODS: Chromosome G-banding was used at the time of diagnosis to evaluate the genetics of chromosomes in patients with NB and track their clinical characteristics and prognosis...
June 9, 2021: Italian Journal of Pediatrics
https://read.qxmd.com/read/33507629/mandibular-metastases-in-neuroblastoma-outcomes-and-dental-sequelae
#32
JOURNAL ARTICLE
Annu Singh, Shakeel Modak, Armand K Solano, Brian H Kushner, Suzanne Wolden, Joseph Huryn, Cherry L Estilo
BACKGROUND: Although metastatic involvement of bony sites including cranial bones is common in neuroblastoma (NB), mandibular metastases (MM) are uncommon, and specific outcomes have not been reported upon in the modern therapeutic era. METHODS: In this retrospective study, medical records on patients with MM from NB were reviewed. Statistical analysis was performed using the Kaplan-Meier method. RESULTS: Of 29 patients, nine (31%) had MM at diagnosis, whereas in 20 (69%) MM were first detected at NB relapse at a median time of 26 (6-89) months from diagnosis...
April 2021: Pediatric Blood & Cancer
https://read.qxmd.com/read/33466359/specific-and-sensitive-detection-of-neuroblastoma-mrna-markers-by-multiplex-rt-qpcr
#33
JOURNAL ARTICLE
Lieke M J van Zogchel, Lily Zappeij-Kannegieter, Ahmad Javadi, Marjolein Lugtigheid, Nina U Gelineau, Nathalie S M Lak, Danny A Zwijnenburg, Jan Koster, Janine Stutterheim, C Ellen van der Schoot, Godelieve A M Tytgat
mRNA RT-qPCR is shown to be a very sensitive technique to detect minimal residual disease (MRD) in patients with neuroblastoma. Multiple mRNA markers are known to detect heterogeneous neuroblastoma cells in bone marrow (BM) or blood from patients. However, the limited volumes of BM and blood available can hamper the detection of multiple markers. To make optimal use of these samples, we developed a multiplex RT-qPCR for the detection of MRD in neuroblastoma. GUSB and PHOX2B were tested as single markers. The adrenergic markers TH , GAP43 , CHRNA3 and DBH and mesenchymal markers POSTN , PRRX1 and FMO3 were tested in multiplex...
January 5, 2021: Cancers
https://read.qxmd.com/read/33394374/metastatic-neuroblastoma-to-the-mandible-of-children-report-of-two-cases-and-critical-review-of-the-literature
#34
REVIEW
Gleyson Kleber do Amaral-Silva, Amanda Almeida Leite, Bruno Augusto Linhares Almeida Mariz, Fernanda Dos Santos Moreira, Márcio Ajudarte Lopes, Ana Carolina Prado Ribeiro, Alan Roger Santos-Silva, André Caroli Rocha, Pablo Agustin Vargas
Neuroblastoma is the most common extracranial solid cancer of infancy, occurring mainly in the adrenal gland, with high metastatic potential. However, involvement of the head and neck region is rare. Here, we present two cases of metastatic neuroblastoma of childhood, in which a mandibular swelling was the first sign of disseminated disease. Case 1 describes a 4-year-old boy with a 2-week history of painful swelling in the left mandibular region, body soreness and weakness. Panoramic radiography and computed tomography showed a destructive lesion in the left mandibular ramus...
September 2021: Head and Neck Pathology
https://read.qxmd.com/read/33287630/mesenchymal-stromal-cells-in-neuroblastoma-exploring-crosstalk-and-therapeutic-implications
#35
REVIEW
Caroline Hochheuser, Laurens J Windt, Nina Y Kunze, Dieuwke L de Vos, Godelieve A M Tytgat, Carlijn Voermans, Ilse Timmerman
Neuroblastoma (NB) is the second most common solid cancer in childhood, accounting for 15% of cancer-related deaths in children. In high-risk NB patients, the majority suffers from metastasis. Despite intensive multimodal treatment, long-term survival remains <40%. The bone marrow (BM) is among the most common sites of distant metastasis in patients with high-risk NB. In this environment, small populations of tumor cells can persist after treatment (minimal residual disease) and induce relapse. Therapy resistance of these residual tumor cells in BM remains a major obstacle for the cure of NB...
January 15, 2021: Stem Cells and Development
https://read.qxmd.com/read/33147765/the-metastatic-bone-marrow-niche-in-neuroblastoma-altered-phenotype-and-function-of-mesenchymal-stromal-cells
#36
JOURNAL ARTICLE
Caroline Hochheuser, Lieke M J van Zogchel, Marion Kleijer, Carlijn Kuijk, Simon Tol, C Ellen van der Schoot, Carlijn Voermans, Godelieve A M Tytgat, Ilse Timmerman
Background : The bone marrow (BM) is the main site of metastases and relapse in patients with neuroblastoma (NB). BM-residing mesenchymal stromal cells (MSCs) were shown to promote tumor cell survival and chemoresistance. Here we characterize the MSC compartment of the metastatic NB BM niche. Methods : Fresh BM of 62 NB patients (all stages), and control fetal and adult BM were studied by flow cytometry using well-established MSC-markers (CD34-, CD45-, CD90+, CD105+), and CD146 and CD271 subtype-markers. FACS-sorted BM MSCs and tumor cells were validated by qPCR...
November 2, 2020: Cancers
https://read.qxmd.com/read/32979173/significance-of-hematopoietic-surface-antigen-cd34-in-neuroblastoma-prognosis-and-the-genetic-landscape-of-cd34-expressing-neuroblastoma-cscs
#37
JOURNAL ARTICLE
Natarajan Aravindan, Dinesh Babu Somasundaram, Terence S Herman, Sheeja Aravindan
High-risk neuroblastoma (HR-NB) is branded with hematogenous metastasis, relapses, and dismal long-term survival. Intensification of consolidation therapy with tandem/triple autologous stem cell (SC) rescue (with bone marrow [BM]/peripheral blood [PB] CD34+ selection) after myeloablative chemotherapy has improved long-term survival. However, the benefit is limited by the indication of NB cells in CD34+ PBSCs, CD34 expression in NB cells, and the risk of reinfusing NB cancer stem cells (NB CSCs) that could lead to post-transplant relapse...
June 2021: Cell Biology and Toxicology
https://read.qxmd.com/read/32568600/analysis-of-treatment-cost-for-neuroblastoma-to-the-family-a-single-center-cross-sectional-study-in-china
#38
JOURNAL ARTICLE
Chiyi Jiang, Siyu Cai, Chao Duan, Na Xu, Yuchen Zhou, Xiaoxia Peng, Xiaoli Ma
BACKGROUND: Neuroblastoma (NB) is notorious in childhood cancer because of its high incidence and poor prognosis. The Children's Oncology Group reported that the 3-year OS in the high-risk (HR) group is 50%, and the HR-NB with bone marrow metastasis in our center is 43.1%. Thousands of families in China suffer from the cost of NB, but the true costs of therapy are unknown; to date, no study has ever performed a detailed therapy costs analysis for NB. The objective of this study was to assess the economic burden of NB treatment in children to the family, to ultimately reduce related expenses for patients and promote the establishment of NB management policy...
June 22, 2020: Journal of Medical Economics
https://read.qxmd.com/read/32046143/modeling-spontaneous-bone-metastasis-formation-of-solid-human-tumor-xenografts-in-mice
#39
JOURNAL ARTICLE
Vera Labitzky, Anke Baranowsky, Hanna Maar, Sandra Hanika, Sarah Starzonek, Ann-Kristin Ahlers, Katrin Stübke, Eva J Koziolek, Markus Heine, Paula Schäfer, Sabine Windhorst, Manfred Jücker, Kristoffer Riecken, Michael Amling, Thorsten Schinke, Udo Schumacher, Ursula Valentiner, Tobias Lange
The majority of cancer-related deaths are due to hematogenous metastases, and the bone marrow (BM) represents one of the most frequent metastatic sites. To study BM metastasis formation in vivo, the most efficient approach is based on intracardiac injection of human tumor cells into immunodeficient mice. However, such a procedure circumvents the early steps of the metastatic cascade. Here we describe the development of xenograft mouse models (balb/c rag2 -/- and severe combined immunodeficient (SCID)), in which BM metastases are spontaneously derived from subcutaneous (s...
February 7, 2020: Cancers
https://read.qxmd.com/read/31879982/pir-39980-promotes-cell-proliferation-migration-and-invasion-and-inhibits-apoptosis-via-repression-of-serpinb1-in-human-osteosarcoma
#40
JOURNAL ARTICLE
Basudeb Das, Neha Jain, Bibekanand Mallick
BACKGROUND INFORMATION: Piwi-interacting RNAs (piRNAs) are a novel class of ∼23-36 nts long endogenous small non-coding RNAs, earlier known to maintain germline genome integrity during development by regulating transposable elements. Recently, piRNAs are known to regulate cell proliferation, apoptosis and metastasis in different cancer cells. However, piRNAs have not yet been reported in human osteosarcoma (OS), a highly metastatic aggressive bone tumour among adolescents. Therefore, our current study aimed to decrypt the potential role of a piRNA, piR-39980 in osteosarcoma, which was earlier reported by us in fibrosarcoma, neuroblastoma and epithelial ovarian cancer...
March 2020: Biology of the Cell
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