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Bone metastasis, neuroblastoma, cancer

G Díaz-Soto, A Rocher, C García-Rodríguez, L Núñez, C Villalobos
The extracellular calcium-sensing receptor (CaSR) is a unique G protein-coupled receptor (GPCR) activated by extracellular Ca(2+) and by other physiological cations including Mg(2+), amino acids, and polyamines. CaSR is the most important master controller of the extracellular Ca(2+) homeostatic system being expressed at high levels in the parathyroid gland, kidney, gut and bone, where it regulates parathyroid hormone (PTH) secretion, vitamin D synthesis, and Ca(2+) absorption and resorption, respectively. Gain and loss of function mutations in the CaSR are responsible for severe disturbances in extracellular Ca(2+) metabolism...
2016: International Review of Cell and Molecular Biology
Kundan Kisanrao Nawale, Monika Vyas, Shubhada Kane, Asawari Patil
INTRODUCTION: The metastatic disease of the jaw bones is very uncommon and accounts for approximately 1% of all malignancies of jaw. The most common location is molar region of mandible. Metastasis may go undetected on a routine skeletal survey for assessment of metastasis and rarely includes jaw bones. AIMS AND OBJECTIVE: The aim of the study is to analyze primary malignancies in metastatic jaw tumors. MATERIALS AND METHODS: We retrospectively studied clinicopathological features of 12 patients of metastasis to jaw bones diagnosed at tertiary cancer center between 2003 and 2011...
May 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
Johannes Fabian, Desirée Opitz, Kristina Althoff, Marco Lodrini, Barbara Hero, Ruth Volland, Anneleen Beckers, Katleen de Preter, Anneleen Decock, Nitin Patil, Mohammed Abba, Annette Kopp-Schneider, Kathy Astrahantseff, Jasmin Wünschel, Sebastian Pfeil, Maria Ercu, Annette Künkele, Jamie Hu, Theresa Thole, Leonille Schweizer, Gunhild Mechtersheimer, Daniel Carter, Belamy B Cheung, Odilia Popanda, Andreas V Deimling, Jan Koster, Rogier Versteeg, Manfred Schwab, Glenn M Marshall, Frank Speleman, Ulrike Erb, Margot Zoeller, Heike Allgayer, Thorsten Simon, Matthias Fischer, Andreas E Kulozik, Angelika Eggert, Olaf Witt, Johannes H Schulte, Hedwig E Deubzer
The systemic and resistant nature of metastatic neuroblastoma renders it largely incurable with current multimodal treatment. Clinical progression stems mainly from the increasing burden of metastatic colonization. Therapeutically inhibiting the migration-invasion-metastasis cascade would be of great benefit, but the mechanisms driving this cycle are as yet poorly understood. In-depth transcriptome analyses and ChIP-qPCR identified the cell surface glycoprotein, CD9, as a major downstream player and direct target of the recently described GRHL1 tumor suppressor...
August 27, 2016: Oncotarget
Okito Hashimoto, Makiko Yoshida, Yu-Ichiro Koma, Tomoko Yanai, Daiichiro Hasegawa, Yoshiyuki Kosaka, Noriyuki Nishimura, Hiroshi Yokozaki
Neuroblastoma is the most common extracranial solid tumour in children and is histologically classified by its Schwannian stromal cells. Although having fewer Schwannian stromal cells is generally associated with more aggressive phenotypes, the exact roles of other stromal cells (mainly macrophages and fibroblasts) are unclear. Here, we examined 41 cases of neuroblastoma using immunohistochemistry for the tumour-associated macrophage (TAM) markers CD68, CD163, and CD204, and a cancer-associated fibroblast (CAF) marker, alpha smooth muscle actin (αSMA)...
October 2016: Journal of Pathology
Michaela Semeraro, Sylvie Rusakiewicz, Laurence Zitvogel, Guido Kroemer
Until recently, the pathophysiological impact of natural killer (NK) lymphocytes has been largely elusive. Capitalizing on our previous discovery that NK cells mediate immunosurveillance against gastrointestinal stromal tumors (GISTs), we have now investigated the potential influence of immunostimulatory and immunosuppressive isoforms of the NK receptor NKp30 on the fate of infants with neuroblastoma. In three independent cohorts of high-risk neuroblastoma, we observed a similar prognostic impact of the ratio of immunostimulatory vs...
November 2015: Oncoimmunology
Mohammed A Eldesouky, Molham A Elbakary
PURPOSE: The aim of the study was to review the demographic, clinical, and imaging features of Egyptian patients with orbital metastases. METHODS: The study was a retrospective study of patients with orbital metastatic lesions over the last 15 years. RESULTS: The study included 37 patients. Male patients represented 54.1%. The primary tumor was breast carcinoma in 21.6% of patients, with hepatocellular carcinoma (HCC) in 16.2% and cutaneous malignant melanoma in 13...
2015: Clinical Ophthalmology
Jia Zhu, Juan Wang, Zi-Jun Zhen, Su-Ying Lu, Fei Zhang, Fei-Fei Sun, Peng-Fei Li, Jun-Ting Huang, Rui-Qing Cai, Xiao-Fei Sun
INTRODUCTION: Brain metastasis is common in relapsed neuroblastoma patients, but the characteristics of brain metastasis remain largely unknown. This study aimed to investigate the status of brain metastasis with neuroblastoma in South China. METHODS: In this retrospective case-based study, 106 patients with stage 4 neuroblastoma from the Department of Pediatric Oncology in Sun Yat-sen University Cancer Center between January 2004 and May 2013 were included. The incidence, risk factors, and survival status of these patients were reviewed and analyzed...
November 2015: Chinese Journal of Cancer
Annick Mühlethaler-Mottet, Julie Liberman, Kelly Ascenção, Marjorie Flahaut, Katia Balmas Bourloud, Pu Yan, Nicolas Jauquier, Nicole Gross, Jean-Marc Joseph
Neuroblastoma (NB) is one of the most deadly solid tumors of the young child, for which new efficient and targeted therapies are strongly needed. The CXCR4/CXCR7/CXCL12 chemokine axis has been involved in the progression and organ-specific dissemination of various cancers. In NB, CXCR4 expression was shown to be associated to highly aggressive undifferentiated tumors, while CXCR7 expression was detected in more differentiated and mature neuroblastic tumors. As investigated in vivo, using an orthotopic model of tumor cell implantation of chemokine receptor-overexpressing NB cells (IGR-NB8), the CXCR4/CXCR7/CXCL12 axis was shown to regulate NB primary and secondary growth, although without any apparent influence on organ selective metastasis...
2015: PloS One
Jens Hw Pahl, Susy J Santos, Marieke L Kuijjer, Gerharda H Boerman, Laurens Gl Sand, Karoly Szuhai, Annemarie Cleton-Jansen, R Maarten Egeler, Judith Vmg Boveé, Marco W Schilham, Arjan C Lankester
Osteosarcoma is the most frequent bone cancer in children and young adults. The outcome of patients with advanced disease is dismal. Exploitation of tumor-immune cell interactions may provide novel therapeutic approaches. CD70-CD27 interactions are important for the regulation of adaptive immunity. CD70 expression has been reported in some solid cancers and implicated in tumor escape from immunosurveillance. In this study, expression of CD70 and CD27 was analyzed in osteosarcoma cell lines and tumor specimens...
2015: Cancer Cell International
Vipin Shankar, Hiroki Hori, Kentaro Kihira, Qi Lei, Hidemi Toyoda, Shotaro Iwamoto, Yoshihiro Komada
Neuroblastoma accounts for 15% of childhood cancer deaths and presents with metastatic disease of the bone and the bone marrow at diagnosis in 70% of the cases. Previous studies have shown that the Mesenchymal Stromal Cell (MSC) secretome, triggers metastases in several cancer types such as breast and prostate cancer, but the specific role of the MSC factors in neuroblastoma metastasis is unclear. To better understand the effect of MSC secretome on chemokine receptors in neuroblastoma, and its role in metastasis, we studied a panel of 20 neuroblastoma cell lines, and compared their invasive potential towards MSC-conditioned-RPMI (mRPMI) and their cytokine receptor expression profiles...
2015: PloS One
Li Li, Yulong Cong, Lili Cai, Xinli Deng, Jie Guan
OBJECTIVE: To analyze the clinical manifestations and hematologic parameters and observe the cytomorphological features of metastatic tumors in the bone marrow originating from different primary sites. METHODS: The clinical data of 77 patients with bone marrow metasta tumors admitted between 2009 and 2014 between 2009 and 2014 in General Hospital of PLA were studied retrospectively to analyze the indications of laboratory examinations (hematological laboratory tests, tumor markers, peripheral blood films, and bone marrow aspirates)...
October 2014: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
Erica L Carpenter, JulieAnn Rader, Jacob Ruden, Eric F Rappaport, Kristen N Hunter, Paul L Hallberg, Kate Krytska, Peter J O'Dwyer, Yael P Mosse
Our understanding of the diversity of cells that escape the primary tumor and seed micrometastases remains rudimentary, and approaches for studying circulating and disseminated tumor cells have been limited by low throughput and sensitivity, reliance on single parameter sorting, and a focus on enumeration rather than phenotypic and genetic characterization. Here, we utilize a highly sensitive microfluidic and dielectrophoretic approach for the isolation and genetic analysis of individual tumor cells. We employed fluorescence labeling to isolate 208 single cells from spiking experiments conducted with 11 cell lines, including 8 neuroblastoma cell lines, and achieved a capture sensitivity of 1 tumor cell per 10(6) white blood cells (WBCs)...
2014: Frontiers in Oncology
Jianguo Feng, Liling Tang
Cell migration and metastasis greatly contribute to the progression of tumors. Secreted Protein and Rich in Cysteine (SPARC), as a multi-faceted protein, is highly expressed in highly metastatic tumors while low or undetectable in less metastatic types with aberrant promoter methylation. In highly metastatic tumors, such as glioblastomas, melanoma, breast cancer and prostate cancer, SPARC promotes bone metastasis and epithelial-mesenchymal transition (EMT). In contrast, this protein acts as an anti-tumor factor in anti-angiogenesis, pro-apoptosis, cell proliferation inhibition and cell cycle arrest in less metastatic tumors, such as neuroblastoma, ovarian cancer, pancreatic cancer, colorectal cancer and gastric cancer...
2014: Current Pharmaceutical Design
Aydıncan Akdur, Mahir Kırnap, Sedat Yıldırım, Özden Altundağ, Gökhan Moray, Mehmet Haberal
OBJECTIVES: The incidence of malignancy is higher in solid-organ transplant recipients compared with the general population. In the present study, we present our experience with de novo malignancies encountered after both deceased-donor and living-donor liver transplants. MATERIALS AND METHODS: We retrospectively reviewed the medical records of 335 patients who underwent an orthotopic liver transplant at our institution between September 2001 and December 2012 to identify subjects with de novo malignancies...
March 2014: Experimental and Clinical Transplantation
Dongliang Cao, Satoshi Kishida, Peng Huang, Ping Mu, Shoma Tsubota, Masaaki Mizuno, Kenji Kadomatsu
Tumorsphere culture enriches and expands tumor cells, thus providing important resources for cancer studies. However, as compared with metastatic tissues, primary tumors in the nervous system rarely give rise to long-surviving tumorspheres, thereby seriously limiting studies on these cancers. This might be due to the limited self-renewal capability of tumor cells and/or to inappropriate culture conditions. The growth and maintenance of tumor cells may depend on microenvironments and/or cell origins (e.g., primary or metastatic; stem cell-like or progenitor-like)...
2014: PloS One
Jun S Wei, Peter Johansson, Li Chen, Young K Song, Catherine Tolman, Samuel Li, Laura Hurd, Rajesh Patidar, Xinyu Wen, Thomas C Badgett, Adam T C Cheuk, Jean-Claude Marshall, Patricia S Steeg, José P Vaqué Díez, Yanlin Yu, J Silvio Gutkind, Javed Khan
Neuroblastoma is one of the most genomically heterogeneous childhood malignances studied to date, and the molecular events that occur during the course of the disease are not fully understood. Genomic studies in neuroblastoma have showed only a few recurrent mutations and a low somatic mutation burden. However, none of these studies has examined the mutations arising during the course of disease, nor have they systemically examined the expression of mutant genes. Here we performed genomic analyses on tumors taken during a 3...
2013: PloS One
Qiang Yang, Jian-min Li, Zhi-ping Yang, Xin Li, Zhen-feng Li, Jun Yan
OBJECTIVE: To investigate the therapeutic effect of total en bloc spondylectomy (TES) for thoracolumbar tumors and the results of spinal stability reconstruction. METHODS: From January 2007 to June 2011 there were 18 patients with thoracolumbar tumors distributed in the thoracic vertebrae (n = 10) and lumbar vertebrae (n = 8). There were 7 haemangiomas, 5 giant cell tumors of bone, 1 malignant schwannoma, 1 solitary plasmocytoma, 1 neuroblastoma, 1 osteoblastoma, 1 metastatic malignant fibrous histiocytoma, and 1 metastasis of breast cancer...
March 2013: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
J Osman, S Galli, M Hanafy, X Tang, A Ahmed
PURPOSE: Neuroblastoma is a common pediatric neoplasm with variable histopathological features that carry an inherent risk of developing distant metastases, in particular bone marrow metastasis. Nestin, X-linked inhibitor of apoptosis (XIAP) and vascular growth factors (VEGF) are biomarkers that are implicated in the tumorigenesis of various cancers. We studied the expression of these biomarkers in neuroblastoma, in relation to bone marrow (BM) metastasis and other histologic parameters...
November 2013: Clinical & Translational Oncology
Tal Teitz, Madoka Inoue, Marcus B Valentine, Kejin Zhu, Jerold E Rehg, Wei Zhao, David Finkelstein, Yong-Dong Wang, Melissa D Johnson, Christopher Calabrese, Marcelo Rubinstein, Razqallah Hakem, William A Weiss, Jill M Lahti
Neuroblastoma, the most common extracranial pediatric solid tumor, is responsible for 15% of all childhood cancer deaths. Patients frequently present at diagnosis with metastatic disease, particularly to the bone marrow. Advances in therapy and understanding of the metastatic process have been limited due, in part, to the lack of animal models harboring bone marrow disease. The widely used transgenic model, the Th-MYCN mouse, exhibits limited metastasis to this site. Here, we establish the first genetic immunocompetent mouse model for metastatic neuroblastoma with enhanced secondary tumors in the bone marrow...
July 1, 2013: Cancer Research
Catherine Rechnitzer
Survival after childhood cancer has dramatically increased in the last 3 to 4 decades. Among extracranial tumours, Wilms tumours and other less common kidney tumours have the best results, but treatment of neuroblastoma, often disseminated at diagnosis, is still extremely challenging. How did survival of solid tumours in childhood increase from around 30% in the 1970s to 70-90% today? This is the result of a multidisciplinary effort and access to improved diagnostic techniques and treatment modalities. This article focuses on the role of imaging in this positive evolution and particularly, how imaging will contribute to keep the survival curves improving...
2011: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
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