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Eline-Claire Grosfeld, Jan Willem M Hoekstra, Ralf-Peter Herber, Dietmar J O Ulrich, John A Jansen, Jeroen J J P van den Beucken
Enhancing degradation of poorly degrading injectable calcium phosphate (CaP) cements (CPCs) can be achieved by adding poly(lactic-co-glycolic acid) (PLGA) microparticles, generating porosity after polymer degradation. CPC-PLGA has proven to be biodegradable, although its long-term biological performance is still unknown. Optimization of injectability could be achieved via addition of carboxymethyl cellulose (CMC). Here, we evaluated the long-term in vivo performance of CPC-PLGA with or without the lubricant CMC in comparison to the devitalized bovine bone mineral (DBBM) predicate device Bio-Oss(®)...
December 9, 2016: Biomedical Materials
Claire I A van Houdt, Dietmar J O Ulrich, John A Jansen, Jeroen J J P van den Beucken
The current study aimed to evaluate the biological performance of calcium phosphate cement (CPC) with polylactic-co-glycolic acid (PLGA) micro-particles and Bio-Oss(®) in ovariectomized and healthy rats. Thirty-two Wistar rats received alternating experimental CPC/PLGA and Bio-Oss(®) in femoral condyle defects in both femurs 6 weeks after ovariectomy (OVX, n = 16) or sham operation (SHAM, n = 16). Six weeks after OVX or SHAM surgery, bone morphology was analyzed by in vivo computed tomography (CT) to confirm osteoporotic bone condition...
November 27, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Babak Amoian, Ehsan Moudi, Maryam Seyed Majidi, S M Ali Tabatabaei
BACKGROUND: Several grafting materials have been used for alveolar ridge augmentation. The literature lacks researches to compare CenoBone to other grafting materials. The aim of this study was to compare CenoBone/CenoMembrane complex to Bio-Oss/Bio-Gide complex in lateral alveolar bone augmentation in terms of radiographic, histologic, and histomorphometric parameters. MATERIALS AND METHODS: In this randomized controlled trial, ten patients who needed lateral ridge augmentation were selected and augmentations were done using either of CenoBone/CenoMembrane or Bio-Oss/Bio-Gide complexes...
September 2016: Dental Research Journal
P Lohmann, A Willuweit, A T Neffe, S Geisler, T P Gebauer, S Beer, H H Coenen, H Fischer, B Hermanns-Sachweh, A Lendlein, N J Shah, F Kiessling, K-J Langen
Bone regeneration can be stimulated by implantation of biomaterials, which is especially important for larger bone defects. Here, healing potency of the porous ArcGel was evaluated in a critical-size calvarial bone defect in rats in comparison with clinical standard autologous bone and Bio-Oss(®) Collagen (BioOss), a bone graft material frequently used in clinics. Bone healing and metabolic processes involved were monitored longitudinally by [(18)F]-fluoride and [(18)F]-FDG μ-PET/CT 1d, 3d, 3w, 6w, and 12w post implantation...
October 28, 2016: Biomaterials
Elise G Zuiderveld, Henny J A Meijer, Arjan Vissink, Gerry M Raghoebar
Single immediate implant replacement is accompanied by excellent survival rates and a favorable esthetic outcome. The objective of this report was to describe a surgical approach for removal of a buccal or palatally located impacted secondary canine, combined with extraction of the failing primary canine, and immediate placement and provisionalization of an implant. A window technique was applied for surgical removal of the impacted canine. The alveolar crest was preserved. After extraction of the primary canine, the implant was inserted with primary stability...
December 2015: International Journal of Implant Dentistry
Eduardo Pinheiro Domingues, Rafael Fernandes Ribeiro, Martinho Campolina Rebello Horta, Flávio Ricardo Manzi, Maurício Greco Côsso, Elton Gonçalves Zenóbio
OBJECTIVE: Using computed tomography, to compare vertical and volumetric bone augmentation after interposition grafting with bovine bone mineral matrix (GEISTLICH BIO-OSS(®) ) or hydroxyapatite/tricalcium phosphate (STRAUMANN(®) BONECERAMIC) for atrophic posterior mandible reconstruction through segmental osteotomy. MATERIAL AND METHODS: Seven patients received interposition grafts in the posterior mandible for implant rehabilitation. The computed tomography cone beam images were analysed with OsiriX Imaging Software 6...
October 4, 2016: Clinical Oral Implants Research
T L M R Dos Anjos, R S de Molon, P R F Paim, E Marcantonio, E Marcantonio, R S Faeda
The aim of this study was to compare implant stability after maxillary sinus floor augmentation using small- or large-sized particles of Bio-Oss. Ten partially edentulous patients requiring bilateral maxillary sinus floor augmentation were enrolled. The subjects were assigned randomly to one of two experimental groups: maxillary sinus was filled with 0.25-1mm particle size (small particles) and the contralateral side was filled with 1-2mm particle size (large particles). After 8 months, a total of 25 implants were placed in the two maxillary sinuses...
September 27, 2016: International Journal of Oral and Maxillofacial Surgery
Fang Wang, Qiong Li, Zuolin Wang
BACKGROUND: To compare the effects of Bio-Oss in combination with concentrated growth factors (CGFs) and bone marrow-derived mesenchymal stem cells (BMSCs) on bone regeneration for maxillary sinus floor augmentation in beagle dogs. METHODS: Six beagle dogs received bilateral maxillary sinus floor augmentation. Venous blood drawn from dogs was collected and centrifugated to obtain CGFs. BMSCs derived from canine bone marrow was cultured using density gradient centrifugation...
September 28, 2016: Journal of Oral Pathology & Medicine
Charlotte Rombouts, Charlotte Jeanneau, Josette Camilleri, Patrick Laurent, Imad About
Adequate revascularization is a prerequisite for successful healing of periodontal bone defects. This study characterized three different xenogeneic bone grafting materials: Gen-Os of equine and porcine origins, and anorganic Bio-Oss. We also investigated their angiogenic potential. All materials were composed of poorly crystalline calcium oxide phosphate, with Bio-Oss exhibiting a carbonated phase and larger particle size and both Gen-Os showing the presence of collagen. Both Gen-Os materials significantly enhanced vascular endothelial growth factor (VEGF) secretion by PDL cells...
December 1, 2016: Dental Materials Journal
Jie Chen, Ge Ma, Wei Liu, Yanpu Liu, Yuxiang Ding
In order to explore the effects of calcitonin gene-related peptide (CGRP) on bone mesenchymal stem cells (BMSCs) from ovariectomized (OVX) rats, an OVX rat model was used. An ELISA was performed to examine the changes in CGRP level in the plasma and skeleton. The BMSCs from the sham rats were designated group A. The BMSCs from the OVX rats (groups B, C, D and E) were treated with different concentrations of CGRP (10(-6), 10(-8), 10(-10) and 0 M) in vitro. The proliferation and osteogenic and adipogenic differentiation potential of the BMSCs were evaluated...
September 13, 2016: Journal of Bone and Mineral Metabolism
Nan Ru, Sean Shih-Yao Liu, Yuxing Bai, Song Li, Yunfeng Liu, Guanjun Zhou
OBJECTIVE:   BoneCeramic can regenerate bone in alveolar defects, but it remains unknown whether it is feasible to move a tooth through BoneCeramic grafting sites. The objective of this study was to investigate three-dimensional real-time bone responses and micromechanical properties in the grafting sites during orthodontic tooth movement. METHODS:   Sixty 5-week-old rats were randomly assigned into three groups to receive BoneCeramic, natural bovine cancellous bone particles (Bio-Oss), and no graft, respectively, after the extraction of the left maxillary first molar...
September 12, 2016: Cleft Palate-craniofacial Journal
Hai-Yan Lin, Wei-Dan Zhang, Yan-Chun Yu, Hong-Yu Jia, Ren-Fei Wang
PURPOSE: To evaluate the effect of overlaying titanium mesh with concentrate growth factors(CGF) for rebuilding severe buccal bone defect of anterior maxilla when used in association with dental implantation. METHODS: Twenty patients with severe buccal bone defect of maxilla were selected. A total of 25 dental implants were placed, including 5 cases in bilateral central incisor area and 15 cases in unilateral central incisor area. After implantation, the defects were treated with Bio-oss and Bio-guid in conjunction with fixation of titanium mesh and then CGF technology was used...
June 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
Nan Ru, Sean Shih-Yao Liu, Yuxing Bai, Song Li, Yunfeng Liu, Guanjun Zhou
OBJECTIVE: To investigate three-dimensional microarchitecture and micromechanical properties of alveolar bone in the BoneCeramic grafting sites during orthodontic tooth movement. MATERIALS AND METHODS: Sixty 5-week-old rats were randomly assigned into three groups to receive BoneCeramic, natural bovine cancellous bone particles (Bio-Oss), and no graft, respectively, after the extraction of the left maxillary first molar. After 4 weeks, the maxillary left second molar was moved into the extraction site for 28 days...
August 30, 2016: Angle Orthodontist
Eylem Ayhan Alkan, Gülay Tüter, Ateş Parlar, Ayşegül Yücel, Bülent Kurtiş
OBJECTIVES: This study compares peri-implant crevicular fluid (PICF) prostaglandin E2 (PGE2) levels, clinical parameters and implant stability quotient (ISQ) values around implants placed in augmented extraction sockets. MATERIALS AND METHODS: The sockets (24 in total) were randomly augmented using either EMD or Bio-Oss Collagen. Implant placements were performed after three months of healing. ISQ readings were evaluated at three points: at the time of surgery, at the first month and at the third month...
October 2016: Acta Odontologica Scandinavica
Ryoe-Woon Kim, Ji-Hyoung Kim, Seong-Yong Moon
BACKGROUND: Xenologous or synthetic graft materials are commonly used as an alternative for autografts for guided bone regeneration. The purpose of this study was to evaluate effectiveness of carbonate apatite on the critical-size bone defect of rat's calvarium. METHODS: Thirty-six critical-size defects were created on 18 adult male Sprague-Dawley rat calvaria under general anesthesia. Calvarial bones were grinded with 8 mm in daimeter bilaterally and then filled with (1) no grafts (control, n = 10 defects), (2) bovine bone mineral (Bio-Oss®, Geistlich Pharma Ag...
December 2016: Maxillofacial Plastic and Reconstructive Surgery
Orion Luiz Haas Junior, Lucas da Silva Meirelles, Neimar Scolari, Otávio Emmel Becker, Marcelo Fernandes Santos Melo, Rogério Belle de Oliveira
INTRODUCTION: Segmental maxillary osteotomy enables correction of anterior open bites. However, the outcome can be somewhat unstable, particularly if pseudarthrosis occurs. Bone grafts can be used to prevent this complication. Among the many biomaterials available for grafting, Bio-oss(®) has been used successfully in a range of modalities, with studies to support several indications. This report describes a case of segmental maxillary osteotomy in which Bio-oss(®) granules were used as bone grafts in the surgical gap...
2016: International Journal of Surgery Case Reports
Filipe de Assis Gonzaga, Tatiana Teixeira de Miranda, Luisa Mourão Dias Magalhães, Walderez Ornelas Dutra, Kenneth John Gollob, Paulo Eduardo Alencar Souza, Martinho Campolina Rebello Horta
In contribution to diverse techniques of bone reconstruction involving biomaterials in contemporary dentistry, this study aimed to evaluate the effect of the bone-grafting materials Bio-Oss(®) and Cerasorb(®) Dental M on the expression of cytokines associated with bone remodeling by human monocytes in vitro. Bio-Oss(®) and Cerasorb(®) Dental M were incubated in separate culture media, and their supernatants were added to mononuclear cells of human peripheral blood, some of which had been stimulated with Porphyromonas gingivalis...
July 12, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Pâmela Letícia Dos Santos, Rafael Scaf de Molon, Thallita Pereira Queiroz, Roberta Okamoto, Ana Paula de Souza Faloni, Jéssica Lemos Gulinelli, Eloá Rodrigues Luvizuto, Idelmo Rangel Garcia
PURPOSE: We sought to evaluate the effectiveness of bone substitutes in circumferential peri-implant defects created in the rabbit tibia. METHODS: Thirty rabbits received 45 implants in their left and right tibia. A circumferential bone defect (6.1 mm in diameter/4 mm depth) was created in each rabbit tibia using a trephine bur. A dental implant (4.1 mm × 8.5 mm) was installed after the creation of the defect, providing a 2-mm gap. The bone defect gaps between the implant and the bone were randomly filled according to the following groups: blood clot (CO), particulate Bio-Oss(®) (BI), and Bio-Oss(®) Collagen (BC)...
June 2016: Journal of Periodontal & Implant Science
Jörg Wiltfang, Michael Rohnen, Jan-Hendrik Egberts, Ulf Lützen, Henning Wieker, Yahya Açil, Hendrik Naujokat
Reconstruction of critical-size jaw defects still remains challenging. The standard treatment today is transplantation of autologous bone grafts, which is associated with high donor-site morbidity and unsatisfactory outcomes. We aimed to reconstruct a mandibular discontinuity defect after ablative surgery using the gastrocolic omentum as a bioreactor for heterotopic ossification. Three-dimensional computed tomography data were used to produce an ideal virtual replacement for the mandibular defect. A titanium mesh cage was filled with bone mineral blocks, infiltrated with 12 mg of recombinant human bone morphogenetic protein 2, and enriched with bone marrow aspirate...
August 2016: Tissue Engineering. Part C, Methods
Vukoman Jokanović, Božana Čolović, Dejan Marković, Milan Petrović, Ivan Soldatović, Djordje Antonijević, Petar Milosavljević, Nikola Sjerobabin, Jelena Sopta
This study examined the potential of a new porous calcium hydroxyapatite scaffold covered with poly (lactide-co-glycolide) (PLGA) as a bone substitute, identifying its advantages over Geistlich Bio-Oss®, considered the gold standard, in in vivo biofunctionality investigations. Structural and morphological properties of the new scaffold were analyzed by scanning electron and atomic force microscopy. The biofunctionality assays were performed on New Zealand white rabbits using new scaffold for filling full-thickness defects of critical size...
June 10, 2016: Biomedizinische Technik. Biomedical Engineering
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