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Thanyaporn Kangwannaronkul, Keskanya Subbalekha, Philaiporn Vivatbutsiri, Jaijam Suwanwela
PURPOSE: Bio-Oss and demineralized freeze-dried bone allograft (DFDBA) are two commercial bone grafts that have been associated with clinical success for many years. However, there are few in vivo studies regarding their healing mechanism. The purpose of this study was to investigate the level of bone formation using microcomputed tomography (micro-CT) and gene expression in mouse calvaria at 1 and 3 months after bone grafting with deproteinized bovine bone and freeze-dried human bone, and compare them to natural bone healing...
March 15, 2018: International Journal of Oral & Maxillofacial Implants
Federico Tirone, Stefano Salzano, Marco Pagano
Healing of extraction sockets may sometimes result in formation of fibrous tissue instead of bone, even after 4 months, an occurrence that may hinder implant placement. The aim of this preliminary observational study was to histologically evaluate quality and amount of bone regeneration after treating nonhealing sockets with a bovine-derived xenograft enriched with porcine collagen (Bio-Oss Collagen, Geistlich) without barrier membranes. Biopsy specimens were collected during implant placement, 4 months after grafting...
March 7, 2018: International Journal of Periodontics & Restorative Dentistry
Yaniv Mayer, Ofir Ginesin, Alaa Khutaba, Eli E Machtei, Hadar Zigdon Giladi
BACKGROUND: Cells, scaffolds, and growth factors are the key components in bone tissue engineering. Scaffold composition, topography, and architecture influence the amount of regenerated bone in the implantation site. The aims of the study were to compare viability and proliferation of mesenchymal stem cells (MSCs) seeded onto two commercial xenografts: Bio-Oss (BO) and bioactive bone bovine (BB). Next, these materials were compared for histomorphometric bone formation in a socket preservation model in rats...
March 6, 2018: Clinical Implant Dentistry and related Research
Shin Kasuya, Nahoko Kato-Kogoe, Michi Omori, Kayoko Yamamoto, Shogo Taguchi, Hiroshi Fujita, Naoko Imagawa, Akihiro Sunano, Kazuya Inoue, Yuichi Ito, Azumi Hirata, Takaaki Ueno, Peter K Moy
PURPOSE: We carried out guided bone regeneration of cranial bone defects in rats using the bovine bone substitute Bio-Oss and a collagen membrane and performed histological observations of the bone repair process. MATERIALS AND METHODS: Bone defects were created in the cranial bones of 30 15-week-old Sprague-Dawley rats. We made 3 groups. A is unfilled, B is Bio-Oss, and C is Bio-Oss plus a collagen membrane. At 4 or 8 weeks postoperatively, tissue samples were taken...
February 26, 2018: Implant Dentistry
Marcus Seiler, Peer W Kaemmerer, Michael Peetz, Amely Gundula Hartmann
The aim of this initial case report was to provide a new protocol for the clinical application of a patient-specific titanium lattice structure (Yxoss CBR®, ReOSS, Filderstadt, Germany) for customized bone regeneration. To obtain a 3-dimensional reconstruction of a posterior mandible segment in a 61-year-old woman, a patient-specific titanium customized lattice structure was used. As graft material autogenous bone tissue mixed with xenogenic alloplastic material (Bio Oss®, Geistlich Pharma, Wolhusen, Switzerland) was obtained for reconstruction...
February 19, 2018: Journal of Oral Implantology
Branko Trajkovski, Matthias Jaunich, Wolf-Dieter Müller, Florian Beuer, Gregory-George Zafiropoulos, Alireza Houshmand
The indication-oriented Dental Bone Graft Substitutes (DBGS) selection, the correct bone defects classification, and appropriate treatment planning are very crucial for obtaining successful clinical results. However, hydrophilic, viscoelastic, and physicochemical properties' influence on the DBGS regenerative potential has poorly been studied. For that reason, we investigated the dimensional changes and molecular mobility by Dynamic Mechanical Analysis (DMA) of xenograft (cerabone®), synthetic (maxresorb®), and allograft (maxgraft®, Puros®) blocks in a wet and dry state...
January 30, 2018: Materials
Liping Zhao, Tao Xu, Wenjie Hu, Kwok-Hung Chung
BACKGROUND: Studies of the extracted infected-molar ridge preservation are limited. PURPOSE: To compare alterations of hard and soft tissue in infected-molar sockets receiving ridge preservation compared with natural healing. MATERIALS AND METHODS: Thirty-five infected-molar extraction sites either preserving with Bio-Gide membrane covered the Bio-Oss material or receiving natural healing procedure as controls. The soft tissue profile was evaluated before tooth extraction and after 6-month healing...
January 29, 2018: Clinical Implant Dentistry and related Research
Mario Vinicius Zendron, Matheus Völz Cardoso, Giovana Fuzeto Veronesi, Daniel Romeu Benchimol de Resende, Carla Andreotti Damante, Adriana Campos Passanezi Sant'ana, Sebastião Luis Aguiar Greghi, Mariana Schutzer Ragghianti Zangrando
PURPOSE: This animal study investigated vertical bone formation (VBF) around implants and used histomorphometric analysis to compare different bone-filling materials associated with a massive titanium dome as a tissue barrier. MATERIALS AND METHODS: Seven dogs were submitted to surgical procedures with extraoral access to the lower edge of the mandible, and four implants were semi-inserted in each animal. Each implant received one treatment: autogenous bone with clot (AB), control clot (C), synthetic graft (Biogran [BG]), or xenograft (Bio-Oss [BO])...
January 19, 2018: International Journal of Oral & Maxillofacial Implants
Hyun-Suk Kim, Ju-Cheol Park, Pil-Young Yun, Young-Kyun Kim
Background: The goal of this study is to evaluate complication and effectiveness of alveolar ridge augmentations using a hydroxyapatite-based alloplastic bony substitute with rhBMP-2. Methods: A total of 10 patients (4 males, 6 females; 58.5 ± 8.6 years) participated in this clinical research. Alveolar ridge augmentations were performed in edentulous (4 maxillary posterior, 5 mandibular posterior, and 1 mandibular anterior) regions. Anorganic bovine bone (ABB; Bio-Oss®, Geistlich Pharma AG, Wolhusen, Switzerland) was used as the bone graft material in the control group (n = 5)) while hydroxyapatite-based alloplastic bony substitute with rhBMP-2(HA+rhBMP-2; NOVOSIS®-Dent, CGBio Inc...
December 2017: Maxillofacial Plastic and Reconstructive Surgery
Stefan Fickl, Frederic Kauffmann, Christian F Stappert, Anke Kauffmann, Ulrich Schlagenhauf
The aim of this retrospective case control study was to compare a porcine collagen matrix (Mucograft Seal, Geistlich) with a free gingival punch graft with respect to size, invagination, and color of resulting soft tissue scar formation. Following definition of inclusion and exclusion criteria, 22 patients were retrospectively included in this study. The patients were divided into two groups. In group A, the extraction socket was filled with bovine bone mineral (Bio-Oss, Geistlich) and covered with a free gingival punch graft...
January 2018: International Journal of Periodontics & Restorative Dentistry
Xian Zhou, Xiu Lian Hu, Jian Hui Li, Ye Lin
OBJECTIVE: To evaluate the effectiveness and clinical results of a new crestal sinus lift technique used to elevate the sinus floor simultaneously with bone grafts and implant placement. METHODS: Eleven patients underwent this crestal sinus lift technique performed using an SCA KIT. The mean residual bone height was 6.4 mm (range: 4.1 mm to 8.6 mm). Bio-Oss collagen was used as the graft material, and 12 implants were simultaneously placed after sinus augmentation...
2017: Chinese Journal of Dental Research
Ferdinand Mabula Machibya, Yiyuan Zhuang, Weizhong Guo, Dongdong You, Shan Lin, Dong Wu, Jiang Chen
OBJECTIVES: To evaluate the effects of bone regeneration materials and orthodontic tooth movement (OTM) timing on tooth movement through alveolar bone defects treated with guided bone regeneration (GBR) utilizing xenografts (Bio-Oss) and alloplast (β-TCP). MATERIALS AND METHODS: Twenty-four standard alveolar bone defects in six male beagle dogs were treated by GBR using either Bio-Oss or β-TCP (experimental), whereas the control defects were left empty. The defects were further grouped into early or late subgroups, depending on OTM timing after GBR (ie 1 month or 2 months, respectively)...
November 20, 2017: Angle Orthodontist
Rongquan Duan, Davide Barbieri, Xiaoman Luo, Jie Weng, Chongyun Bao, Joost D de Bruijn, Huipin Yuan
Because of their bioactive properties and chemical similarity to the inorganic component of bone, calcium phosphate (CaP) materials are widely used for bone regeneration. Six commercially available CaP bone substitutes (Bio-Oss, Actifuse, Bi-Ostetic, MBCP, Vitoss and chronOs) as well as two tricalcium phosphate (TCP) ceramics with either a micron-scale (TCP-B) or submicron-scale (TCP-S) surface structure are characterized and their bone forming potential is evaluated in a canine ectopic implantation model. After 12 weeks of implantation in the paraspinal muscle of four beagles, sporadic bone (0...
November 17, 2017: Biomaterials Science
João Paulo Bonardi, Rodrigo Dos Santos Pereira, Fernanda Brasil Daura Jorge Boos Lima, Leonardo Perez Faverani, Geraldo Luiz Griza, Roberta Okamoto, Eduardo Hochuli-Vieira
PURPOSE: The aim of this study was to compare ChronOS (β-tricalcium phosphate), Bio-Oss, and their addition to an autogenous bone graft in a 1:1 ratio in human maxillary sinus bone augmentation. MATERIALS AND METHODS: Thirty maxillary sinuses were divided in 5 groups: group 1 included 6 maxillary sinuses grafted with autogenous bone graft alone; group 2 included 6 maxillary sinuses grafted with ChronOS; group 3 included 6 maxillary sinuses grafted with ChronOS and autogenous bone graft in a 1:1 ratio; group 4 included 6 maxillary sinuses grafted with Bio-Oss; and group 5 included 6 maxillary sinuses grafted with Bio-Oss and autogenous bone graft in a 1:1 ratio...
February 2018: Journal of Oral and Maxillofacial Surgery
Jonas Lorenz, Tadas Korzinskas, Poju Chia, Sarah Al Maawi, Katrin Eichler, Robert Sader, Shahram Ghanaati
The present prospective randomized split-mouth trial reports on the 3-year clinical and radiological follow-up investigation of implants placed 7 months after sinus augmentation with two different bone substitute materials. Aim of the study was to complete the histologic observation of the cellular reactions by analysis of the implants and the volumetric changes of the augmented bone substitute materials. A sinus augmentation split-mouth trial was performed in 14 patients with the synthetic bone substitute material Nanobone® (NB) and the xenogeneic Bio-Oss® (BO)...
November 1, 2017: Journal of Oral Implantology
Barbara Buffoli, Gaia Favero, Elisa Borsani, Ramon Boninsegna, Guido Sancassani, Mauro Labanca, Rita Rezzani, Pier Francesco Nocini, Massimo Albanese, Luigi Fabrizio Rodella
Surgical techniques in dental and maxillofacial surgery request fast bone tissue regeneration, so there is a significant need to improve therapy for bone regeneration. Several studies have recently underlined the importance of nucleotides and nucleosides to increase cell proliferation and activity; in particular, the ability of polydeoxyribonucleotide (PDRN) to induce growth and activity of human osteoblasts was demonstrated. Sodium-DNA is the deoxyribonucleic acid (DNA) extracted from the gonadic tissue of male sturgeon and then purified, depolymerized, and neutralized with sodium hydroxide...
2017: BioMed Research International
Hanna Aludden, Anna Dahlin, Thomas Starch-Jensen, Christer Dahlin, Arne Mordenfeld
OBJECTIVE: The objective of this study was to estimate the area fraction of different ratios of Bio-Oss(®) and bone, prior to grafting in an in vitro model to demonstrate a histomorphometric baseline. METHODS: Bio-Oss(®) particles were mixed with autogenous bone from pig jaw in three different ratios (50:50, 80:20 and 100:0) and packed in rice paper in a standardized procedure. Histomorphometric analyses were performed in 25 specimens and 74 regions of interest...
October 27, 2017: Clinical Oral Implants Research
Nicolas Grognard, Gino Verleye, Dimitrios Mavreas, Bart Vande-Vannet
BACKGROUND: The healing of xenograft augmentated intra-alveolar gaps following immediate implant placement (IMIP) after tooth extraction is likely to differ in time and density compared to the native bone part that directly contacts the implant. MATERIAL AND METHODS: Secondary implant stability (SIS) data recorded 2-3 months following a late implant placement protocol (LIP) (n= 43) and 6-8 months following an immediate implant placement protocol (IMIP) (n=33) of variable-thread implants (Nobel Active™) in the maxilla were retrospectively collected from files of 63 patients (42 females, 21 males)...
September 2017: Journal of Clinical and Experimental Dentistry
Yuanjing Li, Lan Yang, Zhichao Zheng, Zhengmao Li, Tian Deng, Wen Ren, Caijuan Wu, Lvhua Guo
Bio-Oss(®) and α-calcitonin gene-related peptide (CGRP) are involved in osteogenesis. However, it has remained to be assessed how α-CGRP affects the effect of Bio-Oss. In the present study, primary osteoblasts were incubated with α-CGRP, Bio-Oss, α-GGRP-Bio-Oss or mimic-α-CGRP. The proliferation rate, mineralization nodules, alkaline phosphatase (ALP) activity and the expression of osteogenic genes were measured by a Cell Counting Kit-8 assay, Alizarin Red-S staining, ALP activity detection and reverse-transcription quantitative PCR as well as western blot analysis, respectively...
November 2017: Experimental and Therapeutic Medicine
G Russmueller, L Winkler, R Lieber, R Seemann, K Pirklbauer, C Perisanidis, B Kapeller, E Spassova, E Halwax, W P Poeschl, K Macfelda, D Moser
Much research has been done on bone cells, but only a few studies deal with biomaterial-induced effects on human osteoclasts, which may take on an important role in the successful regeneration of bone. In order to highlight such effects, human peripheral blood mononuclear cells (PBMCs) were extracted from venous blood, differentiated to osteoclasts and then cultured in, the presence of five particulate hydroxyapatite (HA)/β-tricalcium phosphate (TCP) biomaterials, on bovine bone slices and glass cover slips...
October 24, 2017: European Cells & Materials
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