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thymic carcinoma

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https://www.readbyqxmd.com/read/28212996/analysis-of-a-panel-of-druggable-gene-mutations-and-of-alk-and-pd-l1-expression-in-a-series-of-thymic-epithelial-tumors-tets
#1
Marcello Tiseo, Angela Damato, Lucia Longo, Fausto Barbieri, Federica Bertolini, Alessandro Stefani, Mario Migaldi, Letizia Gnetti, Roberta Camisa, Paola Bordi, Sebastiano Buti, Giulio Rossi
INTRODUCTION: Thymic epithelial tumors (TETs) are rare neoplasms with different prognosis lacking consistent molecular alterations possibly leading to targeted therapy. We collected a consecutive series of TETs aimed at investigating the mutational status of druggable genes (EGFR, c-KIT, KRAS, BRAF, PDGFR-alpha and -beta, HER2 and c-MET) and the expression of ALK and PD-L1. PATIENTS AND METHODS: One hundred twelve consecutive cases of TETs and relative clinico-pathologic features were collected...
February 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28183214/appearance-of-a-thymic-mass-after-treatment-of-cushing-s-syndrome
#2
Alessandro P Delitala, Laura Olita, Carla Piras, Rossella Cosseddu, Giorgio Bagella, Giuseppe Fanciulli
A 23-year-old woman was referred to our center with hirsutism, acne, weight gain, weakness, and irregular menses. Laboratory tests revealed increased levels of cortisol and sex hormones, and reduced adrenocorticotropic hormone levels. The patient underwent a right adrenalectomy. Pathology of the resected right adrenal gland showed an adrenal carcinoma. Computed tomography 8 months after the surgery revealed a thymic mass that was not detected preoperatively. The frequency of rebound thymic hyperplasia after normalization of hypercortisolism is not known, but possibly as high as 40%...
February 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/28179162/loss-of-p16-ink4a-expression-and-homozygous-cdkn2a-deletion-are-associated-with-worse-outcome-and-younger-age-in-thymic-carcinomas
#3
Scott W Aesif, Marie Christine Aubry, Eunhee S Yi, Sara M Kloft-Nelson, Sarah M Jenkins, Grant M Spears, Patricia T Greipp, William R Sukov, Anja C Roden
PURPOSE: Thymic carcinomas are aggressive tumors. Biomarkers and alternative treatment modalities are needed. We studied the expression of p16 and cytogenetic abnormalities of CDKN2A and correlated findings with clinical features and outcome in a large cohort of thymic carcinomas. MATERIALS AND METHODS: Thymic carcinomas (1963-2013) were stained with p16. Fluorescence in situ hybridization was utilized to assess for the presence of CDKN2A gene (at 9p21). Statistical analysis was performed...
February 4, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28174490/clinical-value-of-contrast-enhanced-ultrasound-in-improving-diagnostic-accuracy-rate-of-transthoracic-biopsy-of-anterior-medial-mediastinal-lesions
#4
Jingjing Fu, Wei Yang, Song Wang, Jing Bai, Hao Wu, Haiyue Wang, Kun Yan, Minhua Chen
OBJECTIVE: To evaluate the clinical value of contrast-enhanced ultrasound (CEUS) in transthoracic biopsy of anterior-medial mediastinal lesions. METHODS: A total of 123 patients with anterior or middle mediastinum lesions required ultrasound guided transthoracic biopsy for pathological diagnosis. Among them, 72 patients received CEUS examinations before biopsy. After CEUS, 8 patients were excluded from biopsy and the rest 64 patients underwent biopsy (CEUS group)...
December 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28168064/hypercalcemia-of-malignancy-in-thymic-carcinoma-evolving-mechanisms-of-hypercalcemia-and-targeted-therapies
#5
Cheng Cheng, Jose Kuzhively, Sanford Baim
Here we describe, to our knowledge, the first case where an evolution of mechanisms responsible for hypercalcemia occurred in undifferentiated thymic carcinoma and discuss specific management strategies for hypercalcemia of malignancy (HCM). Case Description. We report a 26-year-old male with newly diagnosed undifferentiated thymic carcinoma associated with HCM. Osteolytic metastasis-related hypercalcemia was presumed to be the etiology of hypercalcemia that responded to intravenous hydration and bisphosphonate therapy...
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/28163719/inferior-vena-cava-and-renal-vein-thrombosis-associated-with-thymic-carcinoma
#6
Vlad Teodor Berbecar, Roxana Jurubita, Marina Paraschiv, Bogdan Obrisca, Bogdan Sorohan, Gener Ismail
Thymic tumors are rare mediastinal tumors that can present with a wide variety of symptoms. They can cause distant manifestations and are frequently associated with paraneoplastic syndromes. In our case, we describe the evolution of a 68-year-old male whose first manifestation was thrombosis of the inferior vena cava and renal veins. Thrombosis of large abdominal veins is rare, especially without being associated with any other comorbidity or risk factors.
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28126540/the-impact-of-postoperative-radiotherapy-for-thymoma-and-thymic-carcinoma
#7
Matthew W Jackson, David A Palma, D Ross Camidge, Bernard L Jones, Tyler P Robin, David J Sher, Matthew Koshy, Brian D Kavanagh, Laurie E Gaspar, Chad G Rusthoven
INTRODUCTION: The optimal role for postoperative radiation therapy (PORT) for thymoma and thymic carcinoma remains controversial. We used the National Cancer Database to investigate the impact of PORT on overall survival. METHODS: Patients who underwent surgery for thymoma or thymic carcinoma were categorized into Masaoka-Koga stage groups I-IIA, IIB, III, and IV. Patients who did not undergo surgery or those who received preoperative radiation were excluded. Kaplan-Meier OS estimates, univariate (UVA) and multivariate (MVA) Cox proportional hazards regression analyses were performed...
January 24, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28123154/the-usefulness-of-positron-emission-tomography-findings-in-the-management-of-anterior-mediastinal-tumors
#8
Akihiko Kitami, Fumitoshi Sano, Shinichi Ohashi, Kosuke Suzuki, Shugo Uematsu, Takashi Suzuki, Mitsutaka Kadokura
PURPOSE: We performed a retrospective analysis to evaluate the usefulness of positron-emission tomography/computed tomography (PET/CT) findings in the classification and management of anterior mediastinal tumors. METHODS: Between 2006 and 2015, 105 patients with anterior mediastinal tumor received PET/CT. (18)F-fluorodeoxyglucose ((18)F-FDG)-PET images were obtained 60 minutes after the injection of (18)F-FDG. RESULTS: The histological classifications were as follows: thymoma (n = 49), thymic carcinoma (TC) (n = 19), malignant lymphoma (ML) (n = 8), teratoma (n = 7), thymic cyst (n = 14), and others (n = 8)...
February 20, 2017: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28119349/expression-of-pten-and-its-pseudogene-ptenp1-and-promoter-methylation-of-pten-in-non-tumourous-thymus-and-thymic-tumours
#9
Atsuko Masunaga, Mutsuko Omatsu, Toshiaki Kunimura, Shugo Uematsu, Yoshito Kamio, Akihiko Kitami, Yohei Miyagi, Kenzo Hiroshima, Takashi Suzuki
AIMS: Mutation or promoter methylation of the phosphatase tensin homologue deleted on chromosome 10 tumour suppressor gene (PTEN) promotes some cancers. Moreover, PTENP1 (PTEN pseudogene) transcript regulates PTEN expression and is thought to be associated with tumourigenesis in some cancers. Here, we investigated PTEN expression in thymic epithelium and thymic epithelial tumours. METHODS: Immunohistochemical analysis of PTEN was performed on two non-tumourous thymus (NT) samples, 33 thymomas (three type A, eight type AB, 11 type B1, six type B2, and five type B3), and four thymic carcinomas (TCs)...
January 24, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28116199/a-rare-tumor-with-a-very-rare-initial-presentation-thymic-carcinoma-as-bone-marrow-metastasis
#10
Sonam Sharma, Leelavathi Dawson
Tumors of thymus gland are rare and account for 0.2% to 1.5% of all the neoplasms. They constitute a heterogeneous group that has an unknown etiology and a complex as well as varied biology. This has led to difficulty in their histological classification and in predicting their prognostic and survival markers. Among them, thymic carcinoma is the most aggressive thymic epithelial tumor exhibiting cytological malignant features and a diversity of clinicopathological characteristics that can cause diagnostic dilemmas, misdiagnosis, and therapeutic challenge...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28106503/ct-and-mri-findings-of-thymic-carcinoid
#11
Aya Shimamoto, Kazuto Ashizawa, Yasuo Kido, Hideyuki Hayashi, Takeshi Nagayasu, Atsushi Kawakami, Hiroshi Mukae, Tomayoshi Hayashi, Mayumi Ohtsubo, Kazuto Shigematsu, Takahiko Nakazono, Hidetake Yabuuchi, Masataka Uetani
OBJECTIVES: To evaluate the computed tomography (CT) and magnetic resonance imaging (MRI) findings of thymic carcinoid and to compare these findings with previously published findings of thymoma. METHODS: Eleven cases of pathologically proven thymic carcinoid were reviewed retrospectively. Three patients had typical carcinoid and eight patients had atypical carcinoid. The characteristics of the tumours and related thoracic abnormalities were assessed in each case on CT and/or MRI by two chest radiologists...
January 20, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28095872/an-unusual-combined-thymic-carcinoma-composed-of-squamous-cell-carcinoma-and-type-ab-thymoma-a-rare-case-report
#12
Yufeng Jiang, Yang Liu, Xiuying Shi, Xiaoyun Mao, Yang Zhao, Chuifeng Fan
BACKGROUND: Combined thymic carcinoma is a malignant neoplasm of the thymus recently added to the 4th edition of the World Health Organization (WHO) classification of tumors of the lung, pleura, thymus and heart. It involves at least one type of thymic carcinoma and another thymic epithelial tumor. The previously used term "combined thymic epithelial tumor" has been abandoned. CASE PRESENTATION: Here, we present an unusual case of combined thymic carcinoma of the thymus in a 44-year-old male who had suffered from fever, chest pain, chest tightness and shortness of breath...
January 17, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28087968/thymic-carcinoma-presenting-with-an-unusual-and-delayed-metastasis-to-the-neural-foramen-mimicking-thoracic-spinal-radiculopathy
#13
H M Low, C F Wong, M W H'ng
We report a case of metastatic thymic carcinoma which presented as an enhancing mass located in the neural foramen of the thoracic spine. More common tumours which arise in the neural foramen would include a neurogenic tumour or developmental anomalies such as a foregut duplication cyst. This case is singular firstly because the lesion present as radiculopathy which mimics a neurogenic tumour. Secondly, the presentation was unusually delayed as the patient presented to our centre more than a decade after the resection of the primary tumour in another institution...
December 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28072694/effect-of-hyperthermic-intrathoracic-chemotherapy-hithoc-on-the-malignant-pleural-effusion-a-systematic-review-and-meta-analysis
#14
REVIEW
Hua Zhou, Wei Wu, Xiaoping Tang, Jianying Zhou, Yihong Shen
BACKGROUND: Although hyperthermic intraperitoneal chemotherapy (HIPEC) has been widely used to treat malignant ascites or as a preventive strategy for microscopic carcinomatosis following surgical resection of abdominal tumors, application of hyperthermic intrathoracic chemotherapy (HITHOC) in the treatment of malignant pleural effusion is limited. The objective of the current study was to conduct a systematic review and meta-analysis on the application of HITHOC in the palliative treatment of malignant pleural effusion...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28071625/thymic-epithelial-tumors-can-fluorodeoxyglucose-positron-emission-tomography-help-in-predicting-histologic-type-and-stage
#15
N C Purandare, C S Pramesh, G Karimundackal, S Jiwnani, A Agrawal, S Shah, J P Agarwal, K Prabhash, V Noronha, A Joshi, R Kumar, V Rangarajan
OBJECTIVES: To study the utility of fluorodeoxyglucose (FDG) positron emission tomography (PET) in predicting (1) the World Health Organization (WHO) histologic type and differentiating low-risk from high-risk types. (2) Tumor stage and differentiate early from advanced stage disease. MATERIALS AND METHODS: Patients with thymic epithelial neoplasia who underwent a pretreatment FDG-PET study were included. Tumor maximum standardized uptake value (SUVmax) was correlated with the WHO histologic type and also with the Masaoka-Koga (MK) staging system...
April 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28038793/histologic-characteristics-of-thymic-adenocarcinomas-clinicopathologic-study-of-a-nine-case-series-and-a-review-of-the-literature
#16
Ah-Young Kwon, Joungho Han, Jinah Chu, Yong Soo Choi, Byeong-Ho Jeong, Myung-Ju Ahn, Yong Chan Ahn
Primary thymic adenocarcinoma is an extraordinarily rare malignancy; only 49 cases have been reported in the medical literature to date. Because of its rarity, clinical and pathologic characteristics of thymic adenocarcinoma are unclear. We present nine cases of primary thymic adenocarcinoma and discuss clinicopathologic findings in the context of the existing literature. Two-hundred twenty-six thymic carcinoma cases were diagnosed at Samsung Medical Center in Korea, from January, 2001 to July, 2016. Nine of these 226 cases were primary thymic adenocarcinomas...
November 15, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28007273/complete-resection-of-masaoka-stage-ivb-thymic%C3%A2-carcinoma-after-chemoradiotherapy
#17
Hiroyuki Kayata, Mitsuhiro Isaka, Yasuhisa Ohde, Toshiaki Takahashi, Hideyuki Harada
We report a case of Masaoka stage IVb thymic carcinoma that had metastasized to right supraclavicular lymph nodes, where it would have been difficult to achieve complete resection. Thus, we performed concurrent chemoradiotherapy, which decreased the tumor's size and facilitated complete resection. The patient had an uneventful postoperative course and 30 months of recurrence-free survival. Concurrent chemoradiotherapy followed by complete surgical resection may be a useful strategy in cases of stage IVb thymic carcinoma with supraclavicular lymph node metastasis...
January 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28007263/thymic-and-mediastinal-lymph-node-metastasis-of-colon-cancer
#18
Yoko Yamamoto, Ken Kodama, Yoshihito Ide, Masashi Takeda
Most anterior mediastinal tumors are thymomas. Thymic metastasis from other primary cancers is extremely rare. We report the case of a 72-year-old man who developed thymic and mediastinal lymph node metastases of cecum cancer. He had undergone laparoscopic ileocecal resection with regional lymph node dissection for primary cecum cancer 15 months previously. Follow-up computed tomography revealed tumors in the anterior mediastinum. Fluorodeoxyglucose positron emission tomography showed positive uptake in the tumors...
January 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27999073/prognostic-impact-of-tumour-size-in-completely-resected-thymic-epithelial-tumours
#19
Takayuki Fukui, Koichi Fukumoto, Toshiki Okasaka, Koji Kawaguchi, Shota Nakamura, Shuhei Hakiri, Naoki Ozeki, Akihiro Hirakawa, Hisashi Tateyama, Kohei Yokoi
OBJECTIVES: The T descriptor of thymic epithelial tumours proposed by the International Association for the Study of Lung Cancer and the International Thymic Malignancy Interest Group as well as the Masaoka-Koga system is defined by the anatomical extent of primary tumours, regardless of their size. However, the prognostic significance of tumour size in thymic epithelial tumours has not been fully elucidated. METHODS: We evaluated the prognostic significance of tumour size in 154 consecutive patients with thymic epithelial tumours including 124 thymomas, 21 thymic carcinomas and 9 neuroendocrine tumours, who underwent complete resection between 2001 and 2014...
December 2016: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/27992479/octreotide-lar-and-prednisone-as-neoadjuvant-treatment-in-patients-with-primary-or-locally-recurrent-unresectable-thymic-tumors-a-phase-ii-study
#20
Lukas Kirzinger, Sandra Boy, Jörg Marienhagen, Gerhard Schuierer, Reiner Neu, Michael Ried, Hans-Stefan Hofmann, Karsten Wiebe, Philipp Ströbel, Christoph May, Julia Kleylein-Sohn, Claudia Baierlein, Ulrich Bogdahn, Alexander Marx, Berthold Schalke
Therapeutic options to cure advanced, recurrent, and unresectable thymomas are limited. The most important factor for long-term survival of thymoma patients is complete resection (R0) of the tumor. We therefore evaluated the response to and the induction of resectability of primarily or locally recurrent unresectable thymomas and thymic carcinomas by octreotide Long-Acting Release (LAR) plus prednisone therapy in patients with positive octreotide scans. In this open label, single-arm phase II study, 17 patients with thymomas considered unresectable or locally recurrent thymoma (n = 15) and thymic carcinoma (n = 2) at Masaoka stage III were enrolled...
2016: PloS One
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