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https://www.readbyqxmd.com/read/29785165/thymic-carcinoma-a-rare-case-report
#1
Nidhi Bansal, Arnav Kr Roychoudhury, Harshi Dhingra
Introduction: Thymic carcinoma is a rare, invasive mediastinal neoplasm with a tendency to metastasize. They constitute a heterogeneous group of tumors that present differently in terms of both behavior and prognosis. Case report: We present a case of thymic carcinoma in a 55-year-old male patient known to suffer from Myasthenia gravis, whose chief complaints were fatigability, ptosis and coughing. All electromyography studies were done along with excision biopsy to reach the definitive diagnosis...
2018: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29778330/lymph-node-metastasis-in-thymic-malignancies-a-chinese-multicenter-prospective-observational-study
#2
Wentao Fang, Yun Wang, Liewen Pang, Zhitao Gu, Yucheng Wei, Yongyu Liu, Peng Zhang, Chun Chen, Xinming Zhou, Yangchun Liu, Keneng Chen, Jianyong Ding, Yongtao Han, Yin Li, Zhentao Yu, Yuan Liu, Jianhua Fu
OBJECTIVES: To study the incidence and pattern of lymph node metastases in thymic malignancies. METHODS: This multicenter prospective observational trial with intentional lymph node dissection was carried out by the Chinese Alliance for Research in Thymomas (ChART). Data on patients with thymic tumors without pretreatment were collected prospectively. Results from this prospective study were then compared with those from a previously reported ChART retrospective study...
April 18, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29775980/-comparison-of-the-masaoka-koga-classification-with-the-new-tnm-staging-of-the-iaslc-itmig-for-thymoma-and-thymic-carcinoma
#3
Michael Ried, Maria-Magdalena Eicher, Reiner Neu, Dietmar Kraus, Sebastian Inderhees, Alexander Marx, Hans-Stefan Hofmann
BACKGROUND: The Masaoka-Koga classification describes the extent and spread of thymic epithelial malignancies. The objective of this study was to evaluate the Masaoka-Koga and the new TNM-staging system regarding differences in stage distributions, clinical implementation and therapeutic consequences. METHODS: Retrospective analysis of all patients who underwent surgery between January 2005 and December 2015 for thymoma/thymic carcinoma in two centres for thoracic surgery...
May 18, 2018: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29744727/immunohistochemical-biomarkers-in-thyroid-pathology
#4
REVIEW
Zubair Baloch, Ozgur Mete, Sylvia L Asa
The application of immunohistochemistry to the diagnosis of thyroid lesions has increased as new biomarkers have emerged. In this review, we discuss the biomarkers that are critical for accurate diagnosis, prognosis, and management. Immunohistochemical markers are used to confirm that an unusual tumor in the thyroid is indeed of thyroid origin, either of follicular epithelial or C-cell differentiation; the various mimics include nonthyroidal lesions such as parathyroid tumors, paragangliomas, thymic neoplasms, and metastatic malignancies...
May 9, 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/29740957/egfr-exon-20-insertion-mutation-in-advanced-thymic-squamous-cell-carcinoma-response-to-apatinib-and-clinical-outcomes
#5
Su Yudong, Meng Zhaoting, Wang Xinyue, Lin Li, Xu Xiaoyan, Zuo Ran, Chen Jinliang, Chen Peng
Thymic carcinoma (TC) is a rare malignant tumor of the mediastinum with occult onset, rapid development, and poor prognosis. Surgery is the main treatment for early TC, but the majority of patients are diagnosed at Masaoka-Koga stage III or IV with local invasion or distant metastasis. Platinum and anthracyclines are currently considered key components of first-line chemotherapy for advanced TC; however, there are no standard treatment plans for patients who are refractory to first-line and further chemotherapy...
May 8, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29702286/expression-patterns-prognostic-value-and-intratumoral-heterogeneity-of-pd-l1-and-pd-1-in-thymoma-and-thymic-carcinoma
#6
Dwight Owen, Benjamin Chu, Amy M Lehman, Lakshmanan Annamalai, Jennifer H Yearley, Konstantin Shilo, Gregory A Otterson
INTRODUCTION: Thymic epithelial tumors (TET) including thymoma and thymic carcinoma are rare tumors with little data available to guide treatment. Immunotherapy with checkpoint blockade has shown promising activity, but data regarding the expression patterns and prognostic implications of programmed death 1 (PD-1) and its ligand (PD-L1) in TET have yielded conflicting results. Intratumoral heterogeneity of PD-1/L1 expression has been demonstrated in other cancers but has not been described in the TET literature...
April 24, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29681772/thymic-tumors-and-results-of-radiotherapy
#7
Sureyya Sarıhan, Ahmet Sami Bayram, Cengiz Gebitekin, Omer Yerci, Deniz Sıgırlı
Aim: The aim of this study was to evaluate thymic epithelial tumors (TETs) for treatment outcomes and prognostic factors on survival. Background: TETs are very rare neoplasms and multidisciplinary approach is recommended according to prognostic factors. Materials and methods: Between 1995 and 2013, 31 patients were treated with median 5400 cGy (range: 1620-6596 cGy) radiotherapy (RT). Eleven patients received adjuvant or concurrent chemotherapy...
March 2018: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/29649019/nut-carcinoma-of-the-salivary-glands-clinicopathologic-and-molecular-analysis-of-3-cases-and-a-survey-of-nut-expression-in-salivary-gland-carcinomas
#8
Abbas Agaimy, Isabel Fonseca, Carmo Martins, Khin Thway, Ryan Barrette, Kevin J Harrington, Arndt Hartmann, Christopher A French, Cyril Fisher
NUT carcinoma (NC) represents a rare subset of highly aggressive poorly differentiated carcinomas characterized by rearrangement of the NUT (aka NUTM1, nuclear protein in testis) gene, most commonly fused to BRD4. Originally described as a mediastinal/thymic malignancy, NC has been reported at a variety of anatomic regions including the upper and lower aerodigestive tract. To date, only 7 NC cases of probable salivary gland origin have been reported. We herein describe 3 new cases (all affecting the parotid gland) in 2 women (39- and 55-y old) and 1 man (35-y old)...
April 11, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29645059/diagnosis-of-thymic-epithelial-tumor-subtypes-by-a-quantitative-proteomic-approach
#9
Ting Zhao, Jie Wu, Xiaohui Liu, Lei Zhang, Gang Chen, Haojie Lu
The histological typing of thymic epithelial tumours (TETs) still remains a challenge for surgical pathologists, especially when encountering borderline cases mainly focused on spindle cell types (including type A, atypical type A (aA), AB, and B3). A systematic proteomics analysis of TETs was performed using isobaric tags for relative and absolute quantification (iTRAQ) labeling coupled with two-dimensional liquid chromatography-tandem mass spectrometry (2D-LC-MS/MS). In total, 6479 and 6305 proteins were identified and quantified, respectively...
April 12, 2018: Analyst
https://www.readbyqxmd.com/read/29613961/mr-imaging-of-thymic-epithelial-neoplasms
#10
Brett W Carter, John P Lichtenberger, Marcelo F Benveniste
Thymic epithelial neoplasms are malignant lesions that originate from the thymus and include thymoma, thymic carcinoma, and thymic neuroendocrine tumors. Although computed tomography (CT) is typically considered the imaging modality of choice for identifying thymic tumors, characterizing the primary neoplasm, and staging of disease, the role of magnetic resonance (MR) imaging continues to expand. MR imaging is effective in distinguishing thymic epithelial neoplasms and other malignant tumors from benign lesions in the prevascular mediastinum, can be used to characterize and stage thymic tumors in those patients with contraindications to contrast-enhanced CT, and can reveal morphologic features of thymic tumors...
April 2018: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/29600097/concurrent-thymic-carcinoma-and-middle-lobe-syndrome
#11
Xi Zheng, Yue Huang, Junhe Gou, Daxing Zhu, Qinghua Zhou
Surgery is one of the first-line treatments for thymic carcinoma. Middle lobe syndrome which is irresponsive to conservative therapies also calls for surgical intervention. We reported the case of a 65-year-old male who was diagnosed with coexistent thymic carcinoma and non-obstructive middle lobe syndrome. Before the operation, we took measures including repeated sputum examination, physical therapy, postural sputum drainage and bronchodilator inhalation. After removal of the mediastinal neoplasm, venous antibiotics were used to prevent pneumonia...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29588619/primary-clear-cell-carcinoma-of-the-thymus-and-literature-comparison-of-features
#12
Xiaomin Dai, Li Zhao, Fang Peng
Clear cell carcinoma arising from the thymus is considered exceedingly rare. It shows aggressive clinical behavior and demonstrates frequent local recurrences as well as widespread metastasis. The detailed clinical data of one patient with thymic clear cell carcinoma were compiled, and a review of relevant reported studies was performed. We summarized the clinical characteristics, pathological diagnosis of the patient and other reported cases. The analysis showed that older male patients were more likely to suffer, and the manifestations included chest pain and dyspnea...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29587720/spontaneous-adrenocorticotropic-hormone-acth-normalisation-due-to-tumour-regression-induced-by-metyrapone-in-a-patient-with-ectopic-acth-syndrome-case-report-and-literature-review
#13
Hideyuki Iwayama, Sho Hirase, Yuka Nomura, Tatsuo Ito, Hiroyuki Morita, Kazuo Otake, Akihisa Okumura, Junko Takagi
BACKGROUND: Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is caused by tumours releasing ACTH. Ectopic ACTH-producing tumour regression is rarely induced using steroidogenesis inhibitors. We presented a case of EAS in which ACTH production by a lung tumour was reduced by metyrapone (MTP) and also reviewed previous cases of ectopic ACTH production suppressed via steroidogenesis inhibition. CASE PRESENTATION: A 71-year-old female with general fatigue, central obesity and impaired glucose tolerance was diagnosed with Cushing's syndrome due to elevated ACTH (192...
March 27, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29577488/cytomorphology-and-sonographic-features-of-ectopic-thymic-tissue-diagnosed-in-paediatric-fna-biopsies
#14
F A Escobar, L Pantanowitz, J L Picarsic, F E Craig, J P Simons, P A Viswanathan, S Yilmaz, S E Monaco
INTRODUCTION: Ectopic thymic tissue can arise as an asymptomatic neck mass, which may be detected on imaging studies. The aim of this study was to determine the incidence of ectopic thymic tissue in paediatric FNAs and to the correlate clinical, radiological and cytomorphological findings. METHODS: FNAs in children with neck and mediastinal lesions performed between January 2012 and July 2016 were reviewed for cases of ectopic thymus. These were then evaluated and correlated with the cytology findings...
March 26, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29567820/prognostic-factors-and-efficacy-of-first-line-chemotherapy-in-patients-with-advanced-thymic-carcinoma-a-retrospective-analysis-of-286-patients-from-nej023-study
#15
Ryo Ko, Takehito Shukuya, Yusuke Okuma, Kazunari Tateishi, Hisao Imai, Shunichiro Iwasawa, Eisaku Miyauchi, Akiko Fujiwara, Tomohide Sugiyama, Keisuke Azuma, Keiko Muraki, Masahiro Yamasaki, Hisashi Tanaka, Yuta Takashima, Sayo Soda, Osamu Ishimoto, Nobuyuki Koyama, Satoshi Morita, Kunihiko Kobayashi, Toshihiro Nukiwa, Kazuhisa Takahashi
BACKGROUND: The prognostic factors and the efficacy of first-line chemotherapy remain unclear in patients with advanced thymic carcinoma. MATERIALS AND METHODS: We conducted a multi-institutional retrospective study named NEJ023 for patients with advanced thymic carcinoma. All patients without any indication of curative treatment were treated with chemotherapy from 1995 to 2014 at 40 institutions of the North East Japan Study Group. RESULTS: A total of 286 patients with advanced thymic carcinoma were analyzed...
March 22, 2018: Oncologist
https://www.readbyqxmd.com/read/29557524/secretomes-reveal-several-novel-proteins-as-well-as-tgf-%C3%AE-1-as-the-top-upstream-regulator-of-metastatic-process-in-breast-cancer
#16
Nuray Erin, Nur Ogan, Azmi Yerlikaya
PURPOSE: Metastatic breast cancer is resistant to many conventional treatments and novel therapeutic targets are needed. We previously isolated subsets of 4T1 murine breast cancer cells which metastasized to liver (4TLM), brain (4TBM), and heart (4THM). Among these cells, 4TLM is the most aggressive one, demonstrating mesenchymal phenotype. Here we compared secreted proteins from 4TLM, 4TBM, and 4THM cells and compared with that of hardly metastatic 67NR cells to detect differentially secreted factors involved in organ-specific metastasis...
March 20, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29553964/usefulness-of-volume-perfusion-computed-tomography-in-differentiating-histologic-subtypes-of-thymic-epithelial-tumors
#17
Yong Jing, Wei-Qiang Yan, Gang-Feng Li, Shi-Jun Duan, Shu-Mei Wang, Lin Sun, Yu-Chuan Hu, Guang-Bin Cui
PURPOSE: This study aimed to evaluate the usefulness of volume perfusion computed tomography (VPCT) parameters in differentiating the World Health Organization subtypes of thymic epithelial tumors. MATERIALS AND METHODS: This study was approved by the local ethics committee, and informed written consent was obtained. Fifty-one thymic epithelial tumor patients confirmed by histopathological analysis underwent conventional CT and a 48-second VPCT scan of the tumor bulk before any treatment...
March 16, 2018: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/29551914/a-novel-mechanism-of-tumor-induced-thymic-atrophy-in-mice-bearing-h22-hepatocellular-carcinoma
#18
Sujun Sun, Haiyu Ji, Yingying Feng, Yu Kang, Juan Yu, Anjun Liu
Background: Thymic atrophy was discovered in tumor-bearing mice in recent years. Methods: Flow cytometry was carried out including Annexin V-FITC/PI double staining, PI staining, Terminal dUTP nick-end labeling, CD3-FITC/CD19-PE and CD8-FITC/CD4-PE double staining. Enzyme-linked immunosorbent assay and polymerase chain reaction were also investigated. Results: According to our experiments, we demonstrated that no signs of apoptosis in thymocytes were found in H22-bearing mice, while the proportions of CD4+ T cells and CD8+ T cells in thymuses were remarkably increased, the opposite tendency was found in peripheral bloods, and only CD3+ CD8+ T cells were discovered in H22 solid tumors...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29550202/incidental-detection-of-basaloid-thymic-carcinoma-with-68-ga-psma-11-pet-ct-in-a-patient-with-recurrent-prostate-cancer
#19
Andrea Farolfi, Francesco Ceci, Tiziano Graziani, Alessandro Lambertini, Veronica Cervati, Gian Luca Basilico, Tullio Biraghi, Alberto Briganti, Paolo Castellucci, Stefano Fanti
No abstract text is available yet for this article.
February 23, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29534953/radiographic-predictors-of-resectability-in-thymic-carcinoma
#20
Sara A Hayes, James Huang, Jennifer Golia Pernicka, Jane Cunningham, Junting Zheng, Chaya S Moskowitz, Michelle S Ginsberg
BACKGROUND: The aim of this study was to assess pre-operative computed tomography (CT) characteristics of thymic carcinomas and to investigate which features could predict an incomplete surgical resection. A secondary aim was to correlate pre-operative imaging features with Masaoka stage. METHODS: In this study, approved by our Institutional Review Board, two readers retrospectively reviewed pre-operative CTs at our tertiary referral oncology center between 1994 and 2014...
March 10, 2018: Annals of Thoracic Surgery
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