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thymic carcinoma

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https://www.readbyqxmd.com/read/28932588/kras-mutation-positive-mucinous-adenocarcinoma-originating-in-the-thymus
#1
Ichiro Sakanoue, Hiroshi Hamakawa, Daichi Fujimoto, Yukihiro Imai, Kazuhiro Minami, Keisuke Tomii, Yutaka Takahashi
Thymic carcinoma is a rare, aggressive disease with a low 5-year survival rate. The most common histological neoplastic thymic tumor subtype is squamous cell. We describe an interesting case of a 39-year-old woman who presented with mucinous adenocarcinoma that originated in the thymus and was treated via radical resection and venoplasty of the superior vena cava (SVC). Macroscopically, the resected tumor contained a solid region and multiple cysts with abundant mucin. Microscopic examination showed a papillary growth pattern of goblet cells with round nuclei...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28932541/multimodality-treatment-of-stage-ii-thymic-tumours
#2
Carolina Carillo, Daniele Diso, Sara Mantovani, Ylenia Pecoraro, Tiziano De Giacomo, Anna Maria Ciccone, Camilla Poggi, Flavia Longo, Raffaele Cassese, Vincenzo Tombolini, Erino Angelo Rendina, Federico Venuta, Marco Anile
BACKGROUND: Complete resection for stage II thymic tumors can be easily accomplished even if the capsula and adjacent mediastinal tissue are macroscopically involved; however, also at this stage, recurrence may occur, particularly for B2, B3 and thymic carcinoma. The criteria for the administration of adjuvant therapy remain controversial and it is unclear whether patients at this stage may benefit from it. We reviewed a series of patients at this stage receiving adjuvant chemo-radiotherapy (chemo-RT) based on histology...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28931090/correction-long-term-oncological-outcome-of-thymoma-and-thymic-carcinoma-an-analysis-of-235-cases-from-a-single-institution
#3
Yen-Chiang Tseng, Yen-Han Tseng, Hua-Lin Kao, Chih-Cheng Hsieh, Teh-Ying Chou, Yih-Gang Goan, Wen-Hu Hsu, Han-Shui Hsu
[This corrects the article DOI: 10.1371/journal.pone.0179527.].
2017: PloS One
https://www.readbyqxmd.com/read/28921451/distribution-of-malignant-lymphomas-in-the-anterior-mediastinum-a-single-institution-study-of-76-cases-in-japan-1997-2016
#4
Akiko Miyagi Maeshima, Hirokazu Taniguchi, Tomotaka Suzuki, Sayako Yuda, Kosuke Toyoda, Nobuhiko Yamauchi, Shinichi Makita, Suguru Fukuhara, Wataru Munakata, Dai Maruyama, Yukio Kobayashi, Kensei Tobinai
We analyzed the distribution of tumors and lymphomas of the anterior mediastinum diagnosed between 1997 and 2016 at the National Cancer Center Hospital, Japan. The median age of 283 patients with anterior mediastinal tumors was 48 (range 6-84) years, and 143 (51%) were male. The incidence of tumors was as follows: thymoma, 34%; thymic carcinoma, 16%; primary mediastinal large B-cell lymphoma (PMBL), 13%; germ cell tumors, 10%; classical Hodgkin lymphoma (CHL), 9%; thymic cyst, 7%; metastatic tumors, 3%; T lymphoblastic leukemia/lymphoma (T-LBL), 2%; other lymphomas, 3%; and others, 3%...
September 18, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28890993/chemotherapy-in-nets-when-and-how
#5
REVIEW
Anna Angelousi, Gregory Kaltsas, Anna Koumarianou, Martin O Weickert, Ashley Grossman
The majority of neuroendocrine tumours (NETs) are well-differentiated tumours that follow an indolent course, in contrast to a minority of poorly differentiated neuroendocrine carcinomas (NECs) which exhibit an aggressive course and assocaited with an overall short survival. Although surgery is the only curative treatment for NETs it is not always feasible,necessitating the application of other therapies including chemotherapy. Streptozotocin (STZ)-based regimens have long been used for advanced or metastatic well-to-moderately differentiated (G1-G2) NETs, especially those originating from the pancreas (pNETs)...
September 11, 2017: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/28889760/an-analysis-of-clinical-characteristics-and-patient-outcomes-in-primary-mediastinal-sarcomas
#6
Omar Abdel-Rahman
BACKGROUND: Published data concerning primary mediastinal sarcomas are limited to small-sized retrospective series.  This study reviewed the clinical outcomes of these cases from the SEER (surveillance, epidemiology and end results) database. METHODS: Primary mediastinal sarcomas (1988 - 2013) were assembled from the SEER database. The incidence and 10-year cancer-specific survival rates were compared to other primary mediastinal malignancies (thymic carcinoma, germ cell tumors, neurogenic tumors, Hodgkin / non Hodgkin lymphomas) as well as to non mediastinal sarcomas...
September 14, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28888068/thymic-enteric-type-adenocarcinoma-a-case-report-with-cytological-features
#7
Marie Tamai, Mitsuaki Ishida, Yusuke Ebisu, Hisashi Okamoto, Chika Miyasaka, Chisato Ohe, Yoshiko Uemura, Tomohito Saito, Tomohiro Murakawa, Koji Tsuta
Primary thymic adenocarcinoma is an extremely rare tumor, and thymic enteric type adenocarcinoma has recently been proposed as a distinct pathological entity. Herein, we report the first cytological description of thymic enteric type adenocarcinoma. A 29-year-old Japanese female without a significant past medical history was found to have an abnormal chest shadow. Chest computed tomography demonstrated a well-circumscribed tumor in the anterior mediastinum, and thymectomy was performed. The Papanicolaou staining of the touch smear of the resected tumor demonstrated tightly cohesive epithelial cell clusters in a necrotic background...
September 9, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28879635/ectopic-hamartomatous-thymoma-a-review-of-the-literature-with-report-of-new-cases-and-proposal-of-a-new-name-biphenotypic-branchioma
#8
Kimiya Sato, Lester D R Thompson, Kosuke Miyai, Takako Kono, Hitoshi Tsuda
Ectopic hamartomatous thymoma (EHT) is a rare benign neoplasm of the lower neck suggesting branchial origin. Despite use of the term thymoma in the nomenclature, there is no evidence of thymic origin or differentiation. It affects middle-aged adults with a remarkable male predominance. To date less than 80 cases have been reported in the English literature. We present here two additional cases of EHT. The first is a benign case in a 31-year-old man, showing typical histological features. The second is a malignant case in a 70-year-old woman, showing intraductal carcinoma arising in intimate association with an EHT...
September 6, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28872098/is-a-diagnostic-video-assisted-thoracoscopic-thymectomy-an-acceptable-first-line-approach-to-the-suspicious-anterior-mediastinal-mass
#9
Ricky Vaja, Vijay Joshi, Alan G Dawson, David A Waller
INTRODUCTION: The incidental early-stage thymic mass presents a diagnostic challenge. Video-assisted thoracoscopic (VAT) thymectomy is an attractive but potentially morbid solution. The aim was to show it can be safely applied as a first-line modality in those with undiagnosed thymic enlargement with acceptable long-term results. METHODS: A total of 45 patients were identified (24 male, median age 52 interquartile range [IQR]: 41-66 years) in a 14-year experience who had CT evidence of an enlarged, possibly malignant thymic mass, but no tissue diagnosis before undertaking VAT thymectomy...
October 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/28868014/first-line-treatment-with-carboplatin-plus-nab-paclitaxel-and-maintenance-monotherapy-with-nab-paclitaxel-for-a-thymic-carcinoma-a-case-report
#10
Kunihiko Funaishi, Masahiro Yamasaki, Naomi Saito, Wakako Daido, Sayaka Ishiyama, Naoko Deguchi, Masaya Taniwaki, Nobuyuki Ohashi
Thymic carcinomas are rare malignant tumors, located in the anterior mediastinum. For the treatment of these carcinomas, several chemotherapy regimens have been suggested, including carboplatin plus paclitaxel. However, because of the rarity of these tumors, the standard chemotherapy regimen has not yet been established. Here, we report a case of thymic carcinoma that responded to first-line carboplatin plus nanoparticle albumin-bound paclitaxel (nab-paclitaxel) therapy with continuation maintenance nab-paclitaxel monotherapy...
May 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28844590/surgical-approaches-anaesthetic-management-and-outcome-in-pediatric-superior-mediastinal-tumors
#11
Gehad Ahmed, Mohammed M Hegazy, Tarek Raafat, Hanafy Hafez, Sayed Fadel, Maged Elshafiey
BACKGROUND: Pediatric superior mediastinal tumors are a heterogeneous group of tumors with marked variation in pathology and extension. We reviewed our experience with different surgical approaches to tumors originating from or extending to superior mediastinum in pediatrics. PATIENTS AND METHODS: The medical records of all patients who had undergone resection for superior mediastinal tumors in Children's Cancer Hospital - Egypt, between January 2008 to December 2015, were reviewed for demographic data, clinico-pathological features, radiologic findings, operative techniques and outcome...
August 22, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28840135/assessment-of-mediastinal-tumors-using-suvmax-and-volumetric-parameters-on-fdg-pet-ct
#12
Takahiro Morita, Mitsuaki Tatsumi, Mana Ishibashi, Kayako Isohashi, Hiroki Kato, Osamu Honda, Eku Shimosegawa, Noriyuki Tomiyama, Jun Hatazawa
OBJECTIVES: This study aimed to evaluate the role of pretreatment SUVmax and volumetric FDG positron emission tomography (PET) parameters in the differentiation between benign and malignant mediastinal tumors. In addition, we investigated whether pretreatment SUVmax and volumetric FDG-PET parameters could distinguish thymomas from thymic carcinomas, and low-risk from high-risk thymomas. METHODS: This study was conducted on 52 patients with mediastinal tumors undergoing FDG-PET/CT...
2017: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/28840026/ectopic-right-parietal-pleural-thymic-carcinoma-a-rare-case-and-review-of-the-literature
#13
Haoshuai Zhu, Yiyan Lei, Jianyong Zou, Chunhua Su, Bo Zeng, Yan Li, Honghe Luo
Ectopic thymic carcinoma is extremely rare. We present a case of a 73-year-old male patient with ectopic right parietal pleural thymic carcinoma and performed a literature review. Computed tomography (CT) of the chest demonstrated a sharp-edged soft tissue mass with intense enhancement measuring 47 mm × 29 mm with a broader base adjacent to the right axillary chest wall at the level of the 5th rib. There was no hilar or mediastinal lymphadenopathy or evidence of a mediastinal tumor or pleural nodules. A totally extra-pleural tumor resection and partial right lung resection was performed...
July 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28838380/frequent-silencing-of-rassf1a-by-dna-methylation-in-thymic-neuroendocrine-tumours
#14
Koichiro Kajiura, Hiromitsu Takizawa, Yuki Morimoto, Kiyoshi Masuda, Mitsuhiro Tsuboi, Reina Kishibuchi, Nuliamina Wusiman, Toru Sawada, Naoya Kawakita, Hiroaki Toba, Mitsuteru Yoshida, Yukikiyo Kawakami, Takuya Naruto, Issei Imoto, Akira Tangoku, Kazuya Kondo
OBJECTIVES: Aberrant methylation of promoter CpG islands (CGIs) of tumour suppressor genes is a common epigenetic mechanism underlying cancer pathogenesis. The methylation patterns of thymic tumours have not been studied in detail since such tumours are rare. Herein, we sought to identify genes that could serve as epigenetic targets for thymic neuroendocrine tumour (NET) therapy. MATERIALS AND METHODS: Genome-wide screening for aberrantly methylated CGIs was performed in three NET samples, seven thymic carcinoma (TC) samples, and eight type-B3 thymoma samples...
September 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28810302/-primary-basaloid-thymic-carcinoma-report-of-a-case
#15
D Q Zheng, H J Ruan, L H Yu
No abstract text is available yet for this article.
August 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28796544/journal-club-doubling-time-of-thymic-epithelial-tumors-correlates-with-world-health-organization-histopathologic-classification
#16
Dong Young Jeong, Kyung Soo Lee, Myung Jin Chung, Jae Ill Zo, Young Mog Shim, Jung Won Moon
OBJECTIVE: Awareness of volume doubling times (VDTs) of different thymic epithelial tumors (TETs), including low- and high-grade thymomas and thymic carcinomas, is important for their management. The purpose of this study was to evaluate the VDTs of incidentally found TETs using 3D volumetry (3D-VDT) and longest diameter (LD-VDT). MATERIALS AND METHODS: This retrospective study included 50 patients (30 men, 20 women) who had histologically proven TETs and who underwent at least two serial CT studies at greater than 2-month intervals...
August 10, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28774861/multidisciplinary-tumor-board-decision-making-for-postoperative-radiotherapy-in-thymic-epithelial-tumors-insights-from-the-rythmic-prospective-cohort
#17
Clémence Basse, Sébastien Thureau, Suzanna Bota, Eric Dansin, Pascal-Alexandre Thomas, Eric Pichon, Hervé Lena, Carole Massabeau, Christelle Clement-Duchene, Gilbert Massard, Virginie Westeel, Xavier Quantin, Youssef Oulkhouir, Serge Danhier, Delphine Lerouge, Ronan Tanguy, François Thillays, Cécile Le Pechoux, Bernard Dubray, Luc Thiberville, Benjamin Besse, Nicolas Girard
BACKGROUND: Thymic Epithelial Tumors (TET) are rare intrathoracic malignancies for which surgery represents the mainstay of the treatment. Current practice for postoperative radiotherapy (PORT) is highly variable and there is a lack of prospective, high level evidence. RYTHMIC is the nationwide network for TET in France established in 2012, which prospectively collects data for all TET patients, for whom management is discussed at a national multidisciplinary tumor board (MTB). We assessed whether postoperative radiotherapy (PORT) decisions at the MTB were in accordance with RYTHMIC guidelines, and ultimately implemented in patients...
July 31, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28772352/cytologic-characteristics-of-thymic-adenocarcinoma-with-enteric-differentiation-a-study-of-four-fine-needle-aspiration-specimens
#18
Ah-Young Kwon, Joungho Han, Hae-Yon Cho, Seokhwi Kim, Heejin Bang, Jiyeon Hyeon
Thymic adenocarcinoma is extremely rare. Although its histologic features have been occasionally reported, a lack of description of the cytologic features has hampered the prompt and accurate diagnosis of this condition. Herein, we describe the cytologic findings and histology of four aspiration cytology specimens of thymic adenocarcinoma. The specimens were obtained from primary tumors, metastatic lymph nodes, and pericardial effusions. All four specimens showed three-dimensional glandular clusters with a loss of polarity and nuclear overlapping...
September 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28771603/expression-of-pd-l1-and-other-immunotherapeutic-targets-in-thymic-epithelial-tumors
#19
Kathryn C Arbour, Jarushka Naidoo, Keith E Steele, Ai Ni, Andre L Moreira, Natasha Rekhtman, Paul B Robbins, Joyson Karakunnel, Andreas Rimner, James Huang, Gregory J Riely, Matthew D Hellmann
INTRODUCTION: The thymus is a critical organ for the development of the adaptive immune system and thymic epithelial tumors (TETs; thymomas and thymic carcinomas) are often associated with auto-immune paraneoplastic conditions. However, the immunobiology of TETs is not well described. An evaluation of the tumor microenvironment, with particular focus on expression of immunotherapeutic targets, may facilitate and prioritize development of immunotherapy strategies for patients with TETs...
2017: PloS One
https://www.readbyqxmd.com/read/28758089/diagnosis-of-churg-strauss-syndrome-presented-with-neuroendocrine-carcinoma-a-case-report
#20
Dayun Park, Ho Jun Lee, Kwang Hoon Lee, Bum Sun Kwon, Jin-Woo Park, Ki Yeun Nam, Kyoung Hwan Lee
Churg-Strauss syndrome (CSS) is a rare systemic vasculitis that affect small and medium-sized blood vessels and is accompanied by asthma, eosinophilia, and peripheral neuropathy. This report describes a case of a 52-year-old man who had a history of sinusitis, asthma, and thymus cancer and who had complained of bilateral lower extremity paresthesia and weakness for a month. Peripheral neuropathy was detected by electrodiagnostic studies. Resection of a mediastinal mass, which was diagnosed as thymic neuroendocrine carcinoma, was performed five months before his visit...
June 2017: Annals of Rehabilitation Medicine
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