Yifan Huang, Peng Gao, Tao Qin, Bo Chu, Tao Xu, Jiang Yi, Qian Wang, Zhenqi Yang, Tao Jiang, Jin Fan, Shujie Zhao, Wei Zhou, Jian Chen, Guoyong Yin
Fibrotic scars appear after spinal cord injury (SCI) and are mainly composed of fibroblasts and excess extracellular matrix (ECM), including different types of collagen. The temporal and spatial distribution and role of excess collagens and ECM after SCI are not yet fully understood. Here, we identified that the procollagen type I C-terminal propeptide (PICP), a marker of collagen type I deposition, and bone morphogenetic protein 1 (BMP1), a secreted procollagen c-proteinase (PCP) for type I collagen maturation, were significantly elevatedin cerebrospinal fluid of patients with SCI compared with healthy controls, and were associated with spinal cord compression and neurological symptoms...
April 2023: Matrix Biology: Journal of the International Society for Matrix Biology