Carla Burballa, Laura Llinàs-Mallol, Susana Vázquez, M José Pérez-Sáez, Carlos Arias-Cabrales, Anna Buxeda, José Luís Hernandez, Marta Riera, Sara Sanz, Elisenda Alari, Judith Federico-Vega, Jorge Eguía, Julio Pascual, Dolores Redondo-Pachón, Marta Crespo
BACKGROUND: Alloantibodies, especially anti-human leukocyte antigen antibodies (HLA antibodies), and autoantibodies, as angiotensin II type 1 receptor antibodies (AT1R antibodies), may complicate the access and the course of transplantation. Pregnancy is a known source of HLA antibodies, with most studies evaluating pregnancy-induced sensitization by complement-dependent cytotoxicity assays, mainly after childbirth. AT1R antibodies have been evaluated in the context of preeclampsia. We aimed to evaluate pregnancy as a natural source of HLA antibodies and AT1R antibodies, their dynamics along gestation and the potential factors involved in antibody appearance...
January 17, 2024: Human Immunology