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https://www.readbyqxmd.com/read/28761423/galantamine-protects-against-beta-amyloid-peptide-induced-dna-damage-in-a-model-for-alzheimer-s-disease
#1
Willian O Castillo, Andres Felipe Aristizabal-Pachon
No abstract text is available yet for this article.
June 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28753224/aspergillus-fumigatus-protein-phosphatase-ppza-is-involved-in-iron-assimilation-secondary-metabolite-production-and-virulence
#2
Adriana Oliveira Manfiolli, Patrícia Alves de Castro, Thaila Fernanda Dos Reis, Stephen Dolan, Sean Doyle, Gary Jones, Diego M Riaño Pachón, Mevlüt Ulaş, Luke M Noble, Derek J Mattern, Axel A Brakhage, Vito Valiante, Rafael Silva-Rocha, Ozgur Bayram, Gustavo H Goldman
Metal restriction imposed by mammalian hosts during an infection is a common mechanism of defense to reduce or avoid the pathogen infection. Metals are essential for organism survival due to its involvement in several biological processes. Aspergillus fumigatus causes invasive aspergillosis (IA), a disease that typically manifests in immunocompromised patients. A. fumigatus PpzA, the catalytic subunit of protein phosphatase Z (PPZ), has been recently identified as associated with iron assimilation. A. fumigatus has two high affinity mechanisms of iron acquisition during infection: reductive iron assimilation (RIA) and siderophore-mediated iron uptake...
July 28, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28745575/use-of-exome-sequencing-to-determine-the-full-profile-of-genetic-variants-in-the-fluoropyrimidine-pathway-in-colorectal-cancer-patients-affected-by-severe-toxicity
#3
Marta Pellicer, Xandra García-González, María I García, Carolina Blanco, Pilar García-Alfonso, Luis Robles, Cristina Grávalos, Daniel Rueda, Joaquín Martínez, Vanessa Pachón, Federico Longo, Virginia Martínez, Irene Iglesias, Sara Salvador, María Sanjurjo, Luis A López-Fernández
AIM: To identify genetic variants associated with capecitabine toxicity in fluoropyrimidine pathway genes using exome sequencing. PATIENTS & METHODS: Exomes from eight capecitabine-treated patients with severe adverse reactions (grade >2), among a population of 319, were sequenced (Ion Proton). SNPs in genes classified as potentially damaging (Sorting Intolerant from Tolerant and Polymorphism Phenotyping v2) were tested for association with toxicity in a validation cohort of 319 capecitabine-treated patients...
July 26, 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28713559/draft-genome-sequencing-of-the-sugarcane-hybrid-sp80-3280
#4
Diego Mauricio Riaño-Pachón, Lucia Mattiello
Sugarcane commercial cultivar SP80-3280 has been used as a model for genomic analyses in Brazil. Here we present a draft genome sequence employing Illumina TruSeq Synthetic Long reads. The dataset is available from NCBI BioProject with accession PRJNA272769.
2017: F1000Research
https://www.readbyqxmd.com/read/28704740/comparative-assessment-of-selected-sugarcane-biorefinery-centered-systems-in-brazil-a-multi-criteria-method-based-on-sustainability-indicators
#5
Edgard Gnansounou, Catarina M Alves, Elia Ruiz Pachón, Pavel Vaskan
This work proposes a new sustainability assessment framework aiming to compare selected options of biorefineries subject to provide the same services to a community. At this end, a concept of biorefinery-centered system helps to develop a joint resources and policy-oriented comparison. When an option of biorefinery cannot provide the given amounts of certain services from its own production, it complements its supply portfolio by purchasing the lacking amounts from complementary and conventional production systems...
July 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28699977/pacemaker-implants-in-children-and-adolescents-with-chagas-disease-in-brazil-18-year-incidence
#6
Carolina Christianini Mizzaci, Thiago Gonçalves Schroder E Souza, Gabriel Pelegrineti Targueta, Ana Paula Frederico Tótora, Juan Carlos Pachón Mateos, José Carlos Pachon Mateos
Background: Chagas disease continues to be a serious public health problem, and accounts for 25-30% of the indications for cardiac stimulation in Brazil. Objective: To assess clinical and epidemiological characteristics of patients with Chagas disease, younger than 18 years, who had undergone pacemaker implantation in Brazil between 1994 and 2011, and its temporal trend. Methods: This was a cross-sectional analysis of data from the Brazilian Pacemaker Registry database...
June 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28699001/identification-classification-and-transcriptional-profiles-of-dirigent-domain-containing-proteins-in-sugarcane
#7
Paula Macedo Nobile, Alexandra Bottcher, Juliana L S Mayer, Michael S Brito, Ivan A Dos Anjos, Marcos Guimarães de Andrade Landell, Renato Vicentini, Silvana Creste, Diego Mauricio Riaño-Pachón, Paulo Mazzafera
Dirigent (DIR) proteins, encoded by DIR genes, are referred to as "dirigent" because they direct the outcome of the coupling of the monolignol coniferyl alcohol into (+) or (-) pinoresinol, the first intermediates in the enantiocomplementary pathways for lignan biosynthesis. DIR domain-containing or DIR-like proteins are, thus, termed for not having a clear characterization. A transcriptome- and genome-wide survey of DIR domain-containing proteins in sugarcane was carried out, in addition to phylogenetic, physicochemical and transcriptional analyses...
July 11, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28697549/deamidation-of-pseudopeptidic-molecular-hydrogelators-and-its-application-to-controlled-release
#8
César A Angulo-Pachón, Diego Navarro-Barreda, Celia M Rueda, Francisco Galindo, Juan F Miravet
HYPOTHESIS: The incorporation of a succinic acid-derived moiety in amino acid derivatives would favor an intramolecular catalysis of a deamidation reaction. Such reaction would permit controlled disassembly of molecular hydrogelators and the use of the hydrogels for controlled release of actives. EXPERIMENTAL: Low molecular weight hydrogelators containing a succinic acid-derived moiety were prepared by conventional organic synthesis procedures. Hydrogels were examined by electron microscopy and (1)HNMR studies were carried out to evaluate the solubility in water of the hydrogelators and the deamidation reaction...
July 3, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28666414/comparative-transcriptome-analysis-reveals-different-strategies-for-degradation-of-steam-exploded-sugarcane-bagasse-by-aspergillus-niger-and-trichoderma-reesei
#9
Gustavo Pagotto Borin, Camila Cristina Sanchez, Eliane Silva de Santana, Guilherme Keppe Zanini, Renato Augusto Corrêa Dos Santos, Angélica de Oliveira Pontes, Aline Tieppo de Souza, Roberta Maria Menegaldo Tavares Soares Dal'Mas, Diego Mauricio Riaño-Pachón, Gustavo Henrique Goldman, Juliana Velasco de Castro Oliveira
BACKGROUND: Second generation (2G) ethanol is produced by breaking down lignocellulosic biomass into fermentable sugars. In Brazil, sugarcane bagasse has been proposed as the lignocellulosic residue for this biofuel production. The enzymatic cocktails for the degradation of biomass-derived polysaccharides are mostly produced by fungi, such as Aspergillus niger and Trichoderma reesei. However, it is not yet fully understood how these microorganisms degrade plant biomass. In order to identify transcriptomic changes during steam-exploded bagasse (SEB) breakdown, we conducted a RNA-seq comparative transcriptome profiling of both fungi growing on SEB as carbon source...
June 30, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28648215/erratum-to-renal-graft-survival-according-to-banff-2013-classification-in-indication-biopsies
#10
Carlos Arias-Cabrales, Dolores Redondo-Pachón, María José Pérez-Sáez, Javier Gimeno, Ignacio Sánchez-Güerri, Sheila Bermejo, Adriana Sierra, Carla Burballa, Marisa Mir, Marta Crespo, Julio Pascual
No abstract text is available yet for this article.
May 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28612405/a-comparative-transcriptomic-analysis-of-development-in-two-astyanax-cavefish-populations
#11
Bethany A Stahl, Joshua B Gross
Organisms that are isolated into extreme environments often evolve extreme phenotypes. However, global patterns of dynamic gene expression changes that accompany dramatic environmental changes remain largely unknown. The blind Mexican cavefish, Astyanax mexicanus, has evolved a number of severe cave-associated phenotypes including loss of vision and pigmentation, craniofacial bone fusions, increased fat storage, reduced sleep, and amplified nonvisual sensory systems. Interestingly, surface-dwelling forms have repeatedly entered different caves throughout Mexico, providing a natural set of "replicate" instances of cave isolation...
June 14, 2017: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
https://www.readbyqxmd.com/read/28595961/-flexible-bronchoscopy-in-octogenarians
#12
Antonio Noguera-Sánchez, María J Soler-Sempere, Justo Grau-Delgado, Lucía Zamora-Molina, Isabel Padilla-Navas, Eduardo García-Pachón
No abstract text is available yet for this article.
June 5, 2017: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/28585711/sudden-rhythm-change-in-dual-chamber-pacemaker-is-the-device-working-properly
#13
Miguel A Sastre, Finn Akerström, Marta Pachón, Alberto Puchol, Cristina Martín-Sierra, Marta Flores, Luis Rodríguez-Padial, Miguel A Arias
No abstract text is available yet for this article.
June 6, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28576545/-18-f-fdg-pet-ct-in-the-staging-of-alveolar-rhabdomyosarcoma
#14
Alvaro de Bonilla-Damiá, Rosa Fernández-López, Victor M Pachón-Garrudo, Catalina Márquez-Vega, Isabel Borrego-Dorado
No abstract text is available yet for this article.
May 30, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28558087/executive-summary-of-the-ii-brazilian-guidelines-for-atrial-fibrillation
#15
Luiz Pereira de Magalhães, Marcio Jansen de Oliveira Figueiredo, Fatima Dumas Cintra, Eduardo Benchimol Saad, Ricardo Ryoshim Kuniyoshi, Adalberto Menezes Lorga Filho, Andre Luiz Buchele D'Avila, Angelo Amato Vincenzo de Paola, Carlos Antonio Abunader Kalil, Dalmo Antonio Ribeiro Moreira, Dario Celestino Sobral Filho, Eduardo Back Sternick, Francisco Carlos da Costa Darrieux, Guilherme Fenelon, Gustavo Glotz de Lima, Jacob Atié, José Carlos Pachón Mateos, José Marcos Moreira, José Tarcísio Medeiros de Vasconcelos
No abstract text is available yet for this article.
December 2016: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28521337/perspectives-for-clinical-use-of-engineered-human-host-defense-antimicrobial-peptides
#16
María Eugenia Pachón-Ibáñez, Younes Smani, Jerónimo Pachón, Javier Sánchez-Céspedes
Infectious diseases caused by bacteria, viruses or fungi are among the leading causes of death worldwide. The emergence of drug-resistance mechanisms, especially among bacteria, threatens the efficacy of all current antimicrobial agents, some of them already ineffective. As a result, there is an urgent need for new antimicrobial drugs. Host defense antimicrobial peptides (HDPs) are natural occurring and well-conserved peptides of innate immunity, broadly active against Gram-negative and Gram-positive bacteria, viruses and fungi...
May 1, 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/28518147/survivin-a-key-player-in-cancer-progression-increases-in-obesity-and-protects-adipose-tissue-stem-cells-from-apoptosis
#17
Miriam Ejarque, Victòria Ceperuelo-Mallafré, Carolina Serena, Gisela Pachón, Yaiza Núñez-Álvarez, Margarida Terrón-Puig, Enrique Calvo, Catalina Núñez-Roa, Wilfredo Oliva-Olivera, Francisco J Tinahones, Miguel Angel Peinado, Joan Vendrell, Sonia Fernández-Veledo
Adipose tissue (AT) has a central role in obesity-related metabolic imbalance through the dysregulated production of cytokines and adipokines. In addition to its known risk for cardiovascular disease and diabetes, obesity is also a major risk for cancer. We investigated the impact of obesity for the expression of survivin, an antiapoptotic protein upregulated by adipokines and a diagnostic biomarker of tumor onset and recurrence. In a cross-sectional study of 111 subjects classified by body mass index, circulating levels of survivin and gene expression in subcutaneous AT were significantly higher in obese patients and positively correlated with leptin...
May 18, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28500387/thermal-adaptation-strategies-of-the-extremophile-bacterium-thermus-filiformis-based-on-multi-omics-analysis
#18
F Mandelli, M B Couger, D A A Paixão, C B Machado, C M Carnielli, J A Aricetti, I Polikarpov, R Prade, C Caldana, A F Paes Leme, A Z Mercadante, D M Riaño-Pachón, Fabio Marcio Squina
Thermus filiformis is an aerobic thermophilic bacterium isolated from a hot spring in New Zealand. The experimental study of the mechanisms of thermal adaptation is important to unveil response strategies of the microorganism to stress. In this study, the main pathways involved on T. filiformis thermoadaptation, as well as, thermozymes with potential biotechnological applications were revealed based on omics approaches. The strategy adopted in this study disclosed that pathways related to the carbohydrate metabolism were affected in response to thermoadaptation...
July 2017: Extremophiles: Life Under Extreme Conditions
https://www.readbyqxmd.com/read/28497342/exploration-of-the-acetylcholinesterase-inhibitory-activity-of-some-alkaloids-from-amaryllidaceae-family-by-molecular-docking-in-silico
#19
Willian O Castillo-Ordóñez, Elvira R Tamarozzi, Gabriel M da Silva, Andrés F Aristizabal-Pachón, Elza T Sakamoto-Hojo, Catarina S Takahashi, Silvana Giuliatti
Alzheimer's disease (AD) is a progressive condition, where dementia symptoms gradually worsen. Biochemically the disease is characterized by the presence of neuritic plaques, neurofibrillary tangles, in addition to cholinergic dysfunction in the central nervous system. The role of the cholinergic neurotransmission in AD is the basis of the widely accepted cholinergic hypothesis. Some of the most relevant therapies for the treatment of the disease are based on the acetylcholinesterase (AChE) inhibitor activity; however, these therapies are not effective to stop the disease progression, but only can temporarily slow down the worsening of dementia symptoms, and improve quality of life of patients and their caregivers...
May 11, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28497224/bone-density-microarchitecture-and-material-strength-in-chronic-kidney-disease-patients-at-the-time-of-kidney-transplantation
#20
M J Pérez-Sáez, S Herrera, D Prieto-Alhambra, L Vilaplana, X Nogués, M Vera, D Redondo-Pachón, M Mir, R Güerri, M Crespo, A Díez-Pérez, J Pascual
Bone health is assessed by bone mineral density (BMD). Other techniques such as trabecular bone score and microindentation could improve the risk of fracture's estimation. Our chronic kidney disease (CKD) patients presented worse bone health (density, microarchitecture, mechanical properties) than controls. More than BMD should be done to evaluate patients at risk of fracture. INTRODUCTION: BMD measured by dual-energy X-ray absorptiometry (DXA) is used to assess bone health in end-stage renal disease (ESRD) patients...
May 11, 2017: Osteoporosis International
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