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https://www.readbyqxmd.com/read/28411971/mdrd-or-ckd-epi-for-glomerular-filtration-rate-estimation-in-living-kidney-donors
#1
Carla Burballa, Marta Crespo, Dolores Redondo-Pachón, María José Pérez-Sáez, Marisa Mir, Carlos Arias-Cabrales, Albert Francés, Lluis Fumadó, Lluis Cecchini, Julio Pascual
INTRODUCTION: The evaluation of the measured Glomerular Filtration Rate (mGFR) or estimated Glomerular Filtration Rate (eGFR) is key in the proper assessment of the renal function of potential kidney donors. We aim to study the correlation between glomerular filtration rate estimation equations and the measured methods for determining renal function. MATERIAL AND METHODS: We analysed the relationship between baseline GFR values measured by Tc-(99)m-DTPA (diethylene-triamine-pentaacetate) and those estimated by the four-variable Modification of Diet in Renal Disease (MDRD4) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations in a series of living donors at our institution...
April 12, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28383704/ploidyngs-visually-exploring-ploidy-with-next-generation-sequencing-data
#2
Renato Augusto Corrêa Dos Santos, Gustavo Henrique Goldman, Diego Mauricio Riaño-Pachón
Summary: ploidyNGS is a model-free, open source tool to visualize and explore ploidy levels in a newly sequenced genome, exploiting short read data. We tested ploidyNGS using both simulated and real NGS data of the model yeast Saccharomyces cerevisiae. ploidyNGS allows the identification of the ploidy level of a newly sequenced genome in a visual way. Availability and implementation: ploidyNGS is available under the GNU General Public License (GPL) at https://github...
April 5, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28373284/pathogenic-acinetobacter-species-have-a-functional-type-i-secretion-system-and-contact-dependent-inhibition-systems
#3
Christian M Harding, Marina R Pulido, Gisela Di Venanzio, Rachel L Kinsella, Andrew I Webb, Nichollas E Scott, Jerónimo Pachón, Mario F Feldman
Pathogenic Acinetobacter species, including A. baumannii and A. nosocomialis, are opportunistic human pathogens of increasing relevance worldwide. Although their mechanisms of drug resistance are well studied, the virulence factors that govern Acinetobacter pathogenesis are incompletely characterized. Here we define the complete secretome of A. nosocomialis strain M2 in minimal media and demonstrate that pathogenic Acinetobacter species produce both a functional type I secretion system (T1SS) and a contact dependent inhibition (CDI) system...
April 3, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28361917/the-low-affinity-glucose-transporter-hxtb-is-also-involved-in-glucose-signalling-and-metabolism-in-aspergillus-nidulans
#4
Thaila Fernanda Dos Reis, Benjamin M Nitsche, Pollyne Borborema Almeida de Lima, Leandro José de Assis, Laura Mellado, Steven D Harris, Vera Meyer, Renato A Corrêa Dos Santos, Diego M Riaño-Pachón, Laure Nicolas Annick Ries, Gustavo H Goldman
One of the drawbacks during second-generation biofuel production from plant lignocellulosic biomass is the accumulation of glucose, the preferred carbon source of microorganisms, which causes the repression of hydrolytic enzyme secretion by industrially relevant filamentous fungi. Glucose sensing, subsequent transport and cellular signalling pathways have been barely elucidated in these organisms. This study therefore characterized the transcriptional response of the filamentous fungus Aspergillus nidulans to the presence of high and low glucose concentrations under continuous chemostat cultivation with the aim to identify novel factors involved in glucose sensing and signalling...
March 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28360170/draft-genome-sequence-of-saccharomyces-cerevisiae-barra-grande-bg-1-a-brazilian-industrial-bioethanol-producing-strain
#5
Natalia Coutouné, Aline Tieppo Nogueira Mulato, Diego Mauricio Riaño-Pachón, Juliana Velasco de Castro Oliveira
Here, we present the draft genome sequence of Saccharomyces cerevisiae BG-1, a Brazilian industrial strain widely used for bioethanol production from sugarcane. The 11.7-Mb genome sequence consists of 216 scaffolds and harbors 5,607 predicted protein-coding genes.
March 30, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28347776/identification-of-new-snps-associated-with-severe-toxicity-to-capecitabine
#6
Marta Pellicer, Xandra García-González, María I García, Luis Robles, Cristina Grávalos, Pilar García-Alfonso, Vanessa Pachón, Federico Longo, Virginia Martínez, Carolina Blanco, Irene Iglesias, María Sanjurjo, Luis A López-Fernández
Predicting individual risk of chemotherapy-induced severe adverse reaction is a critical issue when selecting the best treatment for cancer patients. SNPs have been identified in genes involved in the pharmacodynamics of fluoropyrimidines, and guidelines even recommend genotyping some DPYD variants in order to estimate the risk of toxicity. However, the predictive value of this approach remains insufficient, thus limiting its clinical implementation. The aim of the present study was to identify new genetic variants by selecting a group of tag SNPs in genes associated with the pharmacodynamics of fluoropyrimidines (CDA, DPYD, ENOSF1, CES1, TYMS, SLC22A7, TYMP, and UMPS)...
March 27, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28321398/unveiling-the-metabolic-changes-on-muscle-cell-metabolism-underlying-p-phenylenediamine-toxicity
#7
Igor Marín de Mas, Silvia Marín, Gisela Pachón, Juan C Rodríguez-Prados, Pedro Vizán, Josep J Centelles, Romà Tauler, Amaya Azqueta, Vitaly Selivanov, Adela López de Ceraín, Marta Cascante
Rhabdomyolysis is a disorder characterized by acute damage of the sarcolemma of the skeletal muscle leading to release of potentially toxic muscle cell components into the circulation, most notably creatine phosphokinase (CK) and myoglobulin, and is frequently accompanied by myoglobinuria. In the present work, we evaluated the toxicity of p-phenylenediamine (PPD), a main component of hair dyes which is reported to induce rhabdomyolysis. We studied the metabolic effect of this compound in vivo with Wistar rats and in vitro with C2C12 muscle cells...
2017: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/28261220/dual-role-of-natural-killer-cells-on-graft-rejection-and-control-of-cytomegalovirus-infection-in-renal-transplantation
#8
REVIEW
Miguel López-Botet, Carlos Vilches, Dolores Redondo-Pachón, Aura Muntasell, Aldi Pupuleku, José Yélamos, Julio Pascual, Marta Crespo
Allograft rejection constitutes a major complication of solid organ transplantation requiring prophylactic/therapeutic immunosuppression, which increases susceptibility of patients to infections and cancer. Beyond the pivotal role of alloantigen-specific T cells and antibodies in the pathogenesis of rejection, natural killer (NK) cells may display alloreactive potential in case of mismatch between recipient inhibitory killer-cell immunoglobulin-like receptors (KIRs) and graft HLA class I molecules. Several studies have addressed the impact of this variable in kidney transplant with conflicting conclusions; yet, increasing evidence supports that alloantibody-mediated NK cell activation via FcγRIIIA (CD16) contributes to rejection...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28244695/instant-noodles-made-with-fortified-wheat-flour-to-improve-micronutrient-intake-in-asia-a-review-of-simulation-nutrient-retention-and-sensory-studies
#9
Kayla L Bronder, Sarah L Zimmerman, Annoek van den Wijngaart, Karen Codling, Kirsten Ag Johns, Helena Pachón
BACKGROUND AND OBJECTIVES: Consumption of foods made with wheat flour, particularly instant noodles, is increasing in Asia. Given this trend, fortifying wheat flour with vitamins and minerals may improve micronutrient intake in the region. The objective of this review was to understand what is known about fortifying wheat flour used to make instant noodles. METHODS AND STUDY DESIGN: A literature review of seven databases was performed using the search terms "noodle" and ("Asian" or "instant")...
March 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28196534/comparative-genomics-reveals-high-biological-diversity-and-specific-adaptations-in-the-industrially-and-medically-important-fungal-genus-aspergillus
#10
Ronald P de Vries, Robert Riley, Ad Wiebenga, Guillermo Aguilar-Osorio, Sotiris Amillis, Cristiane Akemi Uchima, Gregor Anderluh, Mojtaba Asadollahi, Marion Askin, Kerrie Barry, Evy Battaglia, Özgür Bayram, Tiziano Benocci, Susanna A Braus-Stromeyer, Camila Caldana, David Cánovas, Gustavo C Cerqueira, Fusheng Chen, Wanping Chen, Cindy Choi, Alicia Clum, Renato Augusto Corrêa Dos Santos, André Ricardo de Lima Damásio, George Diallinas, Tamás Emri, Erzsébet Fekete, Michel Flipphi, Susanne Freyberg, Antonia Gallo, Christos Gournas, Rob Habgood, Matthieu Hainaut, María Laura Harispe, Bernard Henrissat, Kristiina S Hildén, Ryan Hope, Abeer Hossain, Eugenia Karabika, Levente Karaffa, Zsolt Karányi, Nada Kraševec, Alan Kuo, Harald Kusch, Kurt LaButti, Ellen L Lagendijk, Alla Lapidus, Anthony Levasseur, Erika Lindquist, Anna Lipzen, Antonio F Logrieco, Andrew MacCabe, Miia R Mäkelä, Iran Malavazi, Petter Melin, Vera Meyer, Natalia Mielnichuk, Márton Miskei, Ákos P Molnár, Giuseppina Mulé, Chew Yee Ngan, Margarita Orejas, Erzsébet Orosz, Jean Paul Ouedraogo, Karin M Overkamp, Hee-Soo Park, Giancarlo Perrone, Francois Piumi, Peter J Punt, Arthur F J Ram, Ana Ramón, Stefan Rauscher, Eric Record, Diego Mauricio Riaño-Pachón, Vincent Robert, Julian Röhrig, Roberto Ruller, Asaf Salamov, Nadhira S Salih, Rob A Samson, Erzsébet Sándor, Manuel Sanguinetti, Tabea Schütze, Kristina Sepčić, Ekaterina Shelest, Gavin Sherlock, Vicky Sophianopoulou, Fabio M Squina, Hui Sun, Antonia Susca, Richard B Todd, Adrian Tsang, Shiela E Unkles, Nathalie van de Wiele, Diana van Rossen-Uffink, Juliana Velasco de Castro Oliveira, Tammi C Vesth, Jaap Visser, Jae-Hyuk Yu, Miaomiao Zhou, Mikael R Andersen, David B Archer, Scott E Baker, Isabelle Benoit, Axel A Brakhage, Gerhard H Braus, Reinhard Fischer, Jens C Frisvad, Gustavo H Goldman, Jos Houbraken, Berl Oakley, István Pócsi, Claudio Scazzocchio, Bernhard Seiboth, Patricia A vanKuyk, Jennifer Wortman, Paul S Dyer, Igor V Grigoriev
BACKGROUND: The fungal genus Aspergillus is of critical importance to humankind. Species include those with industrial applications, important pathogens of humans, animals and crops, a source of potent carcinogenic contaminants of food, and an important genetic model. The genome sequences of eight aspergilli have already been explored to investigate aspects of fungal biology, raising questions about evolution and specialization within this genus. RESULTS: We have generated genome sequences for ten novel, highly diverse Aspergillus species and compared these in detail to sister and more distant genera...
February 14, 2017: Genome Biology
https://www.readbyqxmd.com/read/28182695/two-three-loci-control-scleral-ossicle-formation-via-epistasis-in-the-cavefish-astyanax-mexicanus
#11
Anastasia Lyon, Amanda K Powers, Joshua B Gross, Kelly E O'Quin
The sclera is the protective outer layer of the eye. In fishes, birds, and reptiles, the sclera may be reinforced with additional bony elements called scleral ossicles. Teleost fish vary in the number and size of scleral ossicles; however, the genetic mechanisms responsible for this variation remain poorly understood. In this study, we examine the inheritance of scleral ossicles in the Mexican tetra, Astyanax mexicanus, which exhibits both a cave morph and a surface fish morph. As these morphs and their hybrids collectively exhibit zero, one, and two scleral ossicles, they represent a microcosm of teleost scleral ossicle diversity...
2017: PloS One
https://www.readbyqxmd.com/read/28159569/nonfluoroscopic-catheter-ablation-results-from-a-prospective-multicenter-registry
#12
Miguel Álvarez, Vicente Bertomeu-González, M Fe Arcocha, Pablo Moriña, Luis Tercedor, Ángel Ferrero de Loma, Marta Pachón, Amaya García, Mónica Pardo, Tomás Datino, Concepción Alonso, Joaquín Osca
INTRODUCTION AND OBJECTIVES: Nonfluoroscopic catheter ablation is feasible in most procedures. The aim of our registry was to evaluate the safety and feasibility of a zero-fluoroscopic approach to catheter ablation in several Spanish centers. METHODS: Eleven centers prospectively included a minimum of 20 patients. Patients with an arrhythmic substrate deemed suitable by the operator for a zero-fluoroscopic approach throughout the procedure were recruited. Patients with intracardiac devices were not included...
January 31, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28128094/efficacy-of-ceftaroline-versus-vancomycin-in-an-experimental-foreign-body-and-systemic-infection-model-caused-by-biofilm-producing-methicillin-resistant-staphylococcus-epidermidis
#13
Juan Domínguez-Herrera, Rafael López-Rojas, Younes Smani, Gema Labrador-Herrera, Jerónimo Pachón
In this study, the efficacy of ceftaroline versus vancomycin against biofilm-producing methicillin-resistant Staphylococcus epidermidis (MRSE) in a murine model of foreign-body and systemic infection was compared. Two bacteraemic biofilm-producing MRSE strains were used (SE284 and SE385). The minimum inhibitory concentrations (MICs) for strains SE284 and SE385, were, respectively, 0.25 mg/L and 0.5 mg/L for ceftaroline and 4 mg/L and 2 mg/L for vancomycin. The in vitro bactericidal activities of ceftaroline and vancomycin were evaluated using time-kill curves...
December 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28119484/overproduction-of-outer-membrane-protein-a-ompa-by-acinetobacter-baumannii-is-a-risk-factor-for-nosocomial-pneumonia-bacteremia-and-mortality-increase
#14
Viviana Sánchez-Encinales, Rocío Álvarez-Marín, María Eugenia Pachón-Ibáñez, Felipe Fernández-Cuenca, Alvaro Pascual, José Garnacho-Montero, Luis Martínez-Martínez, Jordi Vila, María Mar Tomás, José Miguel Cisneros, Germán Bou, Jesús Rodríguez-Baño, Jerónimo Pachón, Younes Smani
BACKGROUND: OmpA is a porin involved in Acinetobacter baumannii pathogenesis. However, OmpA clinical implication in hospital-acquired infections remains unknown. We aimed to determine whether OmpA overproduction was a risk factor associated with pneumonia, bacteremia, and mortalilty. METHODS: Demographic, microbiological and clinical data from 100 and 246 patients included, respectively, in a unicenter cohort (UC) and a multicenter cohort (MC) were analyzed. Representative isolates were classified in two groups: i-16 UC and 20 MC isolates from colonized patients (CP) by A...
January 24, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28100806/the-lateral-line-confers-evolutionarily-derived-sleep-loss-in-the-mexican-cavefish
#15
James Jaggard, Beatriz G Robinson, Bethany A Stahl, Ian Oh, Pavel Masek, Masato Yoshizawa, Alex C Keene
Sleep is an essential behavior exhibited by nearly all animals, and disruption of this process is associated with an array of physiological and behavioral deficits. Sleep is defined by changes in sensory gating that reduce sensory input to the brain, but little is known about the neural basis for interactions between sleep and sensory processing. Blind Mexican cavefish comprise an extant surface dwelling form and 29 cave morphs that have independently evolved increased numbers of mechanoreceptive lateral line neuromasts and convergent evolution of sleep loss...
January 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28100795/lateral-line-makes-pach%C3%A3-n-cavefish-sleepless
#16
Kathryn Knight
No abstract text is available yet for this article.
January 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28072755/strategies-for-an-expanded-use-of-kidneys-from-elderly-donors
#17
María José Pérez-Sáez, Núria Montero, Dolores Redondo-Pachón, Marta Crespo, Julio Pascual
The old-for-old allocation policy used for kidney transplantation (KT) has confirmed the survival benefit compared to remaining listed on dialysis. Shortage of standard donors has stimulated the development of strategies aimed to expand acceptance criteria, particularly of kidneys from elderly donors. We have systematically reviewed the literature on those different strategies. In addition to the review of outcomes of expanded criteria donor or advanced age kidneys, we assessed the value of the Kidney Donor Profile Index policy, preimplantation biopsy, dual KT, machine perfusion and special immunosuppressive protocols...
April 2017: Transplantation
https://www.readbyqxmd.com/read/28035778/synthesis-of-a-double-network-supramolecular-hydrogel-by-having-one-network-catalyse-the-formation-of-the-second
#18
Nishant Singh, Chandan Maity, Kai Zhang, César A Angulo-Pachón, Jan H van Esch, Rienk Eelkema, Beatriu Escuder
Self-assembly of biomolecules catalytically controls the formation of natural supramolecular structures, giving highly ordered complex materials. Such desirable hybrid systems are very difficult to design and construct synthetically. A hybrid double-network hydrogel with a maximum storage modulus (G'max ) of up to 55 kPa can be synthesized by using a self-assembled hydrogel that catalyses the formation of another kinetically arrested hydrogel network. Tuning of the catalytic efficiency of the first network allowed spatiotemporal control over the evolution of the second network and the resulting mechanical properties...
December 30, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27992986/-effect-of-genetics-epigenetics-and-variations-in-the-transcriptional-expression-of-cadherin-e-in-breast-cancer-susceptibility
#19
Andrés Felipe Aristizábal-Pachón, Catarina Satie Takahashi
INTRODUCTION: Cadherin-E (CDH1) is an important regulator of epithelial-mesenchymal transition, invasion and metastasis in many carcinomas. However, germinal epimutations and mutations effect in breast cancer susceptibility is not clear. OBJECTIVE: To evaluate rs334558 polymorphism, promoter methylation status and CDH1 expression profile in breast cancer patients. MATERIALS AND METHODS: We collected peripheral blood samples from 102 breast cancer patients and 102 healthy subjects...
December 1, 2016: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/27992528/colistin-dosage-without-loading-dose-is-efficacious-when-treating-carbapenem-resistant-acinetobacter-baumannii-ventilator-associated-pneumonia-caused-by-strains-with-high-susceptibility-to-colistin
#20
Rocío Álvarez-Marín, Rafael López-Rojas, Juan Antonio Márquez, María José Gómez, José Molina, José Miguel Cisneros, Carlos Ortiz-Leyba, Javier Aznar, José Garnacho-Montero, Jerónimo Pachón
OBJECTIVES: This study aims to analyze the mortality and the length of ICU stay (LOS) of A. baumannii VAP compared to respiratory colonization in patients with mechanical ventilation (MV). METHODS: A prospective cohort study was performed in an ICU of adult patients (February 2010-June 2011). One hundred patients on MV with A. baumannii in lower respiratory airways were recruited, and classified as VAP or airways colonization according to CPIS criteria, with a punctuation ≥6...
2016: PloS One
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