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L Diaz-Balteiro, P Belavenutti, M Ezquerro, J González-Pachón, S Ribeiro Nobre, C Romero
There is an important body of literature using multi-criteria distance function methods for the aggregation of a battery of sustainability indicators in order to obtain a composite index. This index is considered to be a proxy of the sustainability goodness of a natural system. Although this approach has been profusely used in the literature, it is not exempt from difficulties and potential pitfalls. Thus, in this paper, a significant number of critical issues have been identified showing different procedures capable of avoiding, or at least of mitigating, the inherent potential pitfalls associated with each one...
March 8, 2018: Journal of Environmental Management
Redondo-Pachón Dolores, Pérez-Sáez María José, Mir Marisa, Gimeno Javier, Llinás Laura, García Carmen, Hernández Juan José, Yélamos Jose, Pascual Julio, Crespo Marta
Preformed HLA donor-specific antibodies (DSA) only detected with Luminex have been associated with increased risk of antibody-mediated rejection (ABMR) and graft failure after kidney transplantation (KT). Their evolution after KT may modify this risk. We analyzed postransplant evolution of preformed DSA identified retrospectively and their impact on outcomes of 370 KT performed 2006-2014. Antibodies were monitored prospectively at 1-3-5 years after KT and if any dysfunction. Early acute ABMR was more frequent among patients with preformed DSA class-I or I+II than isolated class-II (29...
March 7, 2018: Human Immunology
Gonzalo Duarte, Rashel Cheja, Diana Pachón, Carolina Ramírez, Lourdes Arellanes
Purpose: To report two cases of eyeball tattoos with short-term post procedural complications. Observations: Case 1 is a 26-year-old Mexican man that developed orbital cellulitis and posterior scleritis 2 h after an eyeball tattoo. Patient responded satisfactorily to systemic antibiotic and corticosteroid treatment. Case 2 is a 17-year-old Mexican man that developed two sub-episcleral nodules in the ink injection sites immediately after the procedure. Conclusions and importance: Eyeball tattoos are performed by non-ophthalmic trained personnel...
April 2017: American Journal of Ophthalmology Case Reports
V M Pachón-Garrudo, J J Martín-Marcuartu, Á de Bonilla-Damiá, J M Jiménez-Hoyuela-García
No abstract text is available yet for this article.
February 28, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
Leonardo Palacios-Sánchez, Juan Sebastián Botero-Meneses, Rocío Plazas Pachón, Laura Bibiana Pineros Hernández, Juanita Del Pilar Triana-Melo, Santiago Ramírez-Rodríguez
It could be argued that one of the few unifying qualities all human beings share is the ability to appreciate beauty. While the object of beauty may change from one person to another, the awe and the thrill experienced by an enthralled beholder remains the same. Sometimes, this experience can be so overwhelming it can bring someone to the edge of existence. A very rare condition, known as aesthetic syndrome and, more commonly, Stendhal syndrome, entails a clinical phenomenon in which the presence of a beautiful piece of work or architecture causes dysautonomic symptoms such as tachycardia, diaphoresis, chest pains and loss of consciousness...
February 2018: Arquivos de Neuro-psiquiatria
Hu Zhan, J Anthony Tyson
The Large Synoptic Survey Telescope (LSST) is a high etendue imaging facility that is being constructed atop Cerro Pachon in Northern Chile. It is scheduled to begin science operations in 2022. With an 8.4m (6.5m effective) aperture, a novel three-mirror design achieving a seeing-limited 9.6deg^2 field of view, and a 3.2 Gigapixel camera, the LSST has the deep-wide-fast imaging capability necessary to carry out an 18,000deg^2 survey in six passbands (ugrizy) to a coadded depth of r~27.5 over 10 years using 90% of its observational time...
February 23, 2018: Reports on Progress in Physics
David Calvo, Diego Pérez, José Rubín, Daniel García, Pablo Ávila, F Javier García-Fernández, Marta Pachón, Loreto Bravo, Jesús Hernández, Ángel L Miracle, Irene Valverde, Mar Gozalez-Vasserot, Miguel Ángel Árias, Javier Jimenez-Candíl, César Morís
Aims: Tachycardia mediated by septal accessory pathways (AP) and atypical atrioventricular nodal re-entry (AVNRT) require careful electrophysiologic evaluation for differential diagnosis. We aim to describe the differential behaviour of local ventriculo-atrial (VA) intervals which predicts the tachycardia mechanism. Methods and results: The local VA intervals at the para-Hisian septum were measured under three different situations: (i) tachycardia; (ii) sustained entrainment from the right ventricular apex (RVA); and (iii) continuous pacing from the RVA during sinus rhythm...
January 2, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
José Carlos Pachón-M, Enrique I Pachón-M, Tomas G Santillana P, Tasso Julio Lobo, Carlos Thiene C Pachón, Juán Carlos Pachón-M, Remy Nelson Albornoz V, Juán Carlos Zerpa A, Felipe Ortencio, Mauricio Arruda
Background: Catheter ablation of long-standing persistent AF (LSAF) remains challenging. Since AF-Nest (AFN) description, we have observed that a stable, protected, fast source firing, namely "Background Tachycardia"(BT), could be hidden beneath the chaotic AF. Following pulmonary vein isolation (PVI)+AFN ablation one or more BT may arise or be induced in 30-40% of patients, which could be the culprit forAF maintenance and ablation recurrences. Methods and Results: We studied 114 patients, from 322 sequential LSAF regular ablations, having spontaneous or induced residual BT after EGM-guided PVI+AFN ablation of LSAF; 55...
August 2017: Journal of Atrial Fibrillation
Miguel A Arias, Marta Pachón, Finn Akerström, Alberto Puchol, Cristina Martín-Sierra, Luis Rodríguez-Padial
INTRODUCTION AND OBJECTIVES: The subcutaneous implantable cardioverter-defibrillator (S-ICD) has emerged as an alternative to the transvenous defibrillator. The incidence of complications is similar, with inappropriate shocks (IS) being more frequent than those occurring with contemporary programming of transvenous defibrillators. Several improvements have been implemented after the S-ICD was approved for use in Europe in 2009. This study reports the results of S-ICD use in a single center, whose experience began late, at the end of 2013...
December 5, 2017: Revista Española de Cardiología
Natalia M Moreno-Pachon, Marie-Chantal Mutimawurugo, Eveline Heynen, Lidiya Sergeeva, Anne Benders, Ikram Blilou, Henk W M Hilhorst, Richard G H Immink
Tulip vegetative reproduction. Tulips reproduce asexually by the outgrowth of their axillary meristems located in the axil of each bulb scale. The number of axillary meristems in one bulb is low, and not all of them grow out during the yearly growth cycle of the bulb. Since the degree of axillary bud outgrowth in tulip determines the success of their vegetative propagation, this study aimed at understanding the mechanism controlling the differential axillary bud activity. We used a combined physiological and "bottom-up" molecular approach to shed light on this process and found that first two inner located buds do not seem to experience dormancy during the growth cycle, while mid-located buds enter dormancy by the end of the growing season...
December 7, 2017: Plant Reproduction
Victor Simon, Romain Elleboode, Kélig Mahé, Laurent Legendre, Patricia Ornelas-Garcia, Luis Espinasa, Sylvie Rétaux
Background: Life in the darkness of caves is accompanied, throughout phyla, by striking phenotypic changes including the loss or severe reduction in eyes and pigmentation. On the other hand, cave animals have undergone constructive changes, thought to be adaptive, to survive in this extreme environment. The present study addresses the question of the evolution of growth in caves, taking advantage of the comparison between the river-dwelling and the cave-dwelling morphs of the Mexican tetra, Astyanax mexicanus ...
2017: EvoDevo
Julio César Padilla, Fredy Eberto Lizarazo, Olga Lucía Murillo, Fernando Antonio Mendigaña, Edwin Pachón, Mauricio Javier Vera
Introducción. Las enfermedades transmitidas por vectores representan más de 17 % de todas las enfermedades infecciosas y causan anualmente un millón de defunciones a nivel mundial. En Colombia, la malaria, el dengue, la enfermedad de Chagas y las leishmaniasis son condiciones endemoepidémicas persistentes.Objetivo. Determinar el comportamiento epidemiológico de las enfermedades transmitidas por vectores en zonas urbanas y rurales de Colombia entre 1990 y 2016.Materiales y métodos. Se hizo un estudio descriptivo del comportamiento epidemiológico de las principales enfermedades transmitidas por vectores en zonas urbanas y rurales de Colombia entre 1990 y 2016, con la información proveniente de fuentes oficiales secundarias...
March 29, 2017: Biomédica: Revista del Instituto Nacional de Salud
Blanca Escudero-López, Ángeles Ortega, Isabel Cerrillo, María-Rosario Rodríguez-Griñolo, Rocío Muñoz-Hernández, Hada C Macher, Franz Martín, Dámaso Hornero-Méndez, Pedro Mena, Daniele Del Rio, María-Soledad Fernández-Pachón
BACKGROUND: Alcoholic fermentation of fruits has generated novel products with high concentrations of bioactive compounds and moderate alcohol content. The aim of this study was to evaluate the potential effect on cardiovascular risk factors of the regular consumption by healthy humans of a beverage obtained by alcoholic fermentation and pasteurization of orange juice. RESULTS: Thirty healthy volunteers were enrolled in a randomized controlled study. The experimental group (n = 15) drank 500 mL orange beverage (OB) per day for 2 weeks (intervention phase), followed by a 3-week washout phase...
November 9, 2017: Journal of the Science of Food and Agriculture
Bruno L Mello, Anna M Alessi, Diego M Riaño-Pachón, Eduardo R deAzevedo, Francisco E G Guimarães, Melissa C Espirito Santo, Simon McQueen-Mason, Neil C Bruce, Igor Polikarpov
Background: Using globally abundant crop residues as a carbon source for energy generation and renewable chemicals production stand out as a promising solution to reduce current dependency on fossil fuels. In nature, such as in compost habitats, microbial communities efficiently degrade the available plant biomass using a diverse set of synergistic enzymes. However, deconstruction of lignocellulose remains a challenge for industry due to recalcitrant nature of the substrate and the inefficiency of the enzyme systems available, making the economic production of lignocellulosic biofuels difficult...
2017: Biotechnology for Biofuels
Xavier Vila-Farrés, Raquel Parra-Millán, Viviana Sánchez-Encinales, Monica Varese, Rafael Ayerbe-Algaba, Nuria Bayó, Salvador Guardiola, María Eugenia Pachón-Ibáñez, Martin Kotev, Jesús García, Meritxell Teixidó, Jordi Vila, Jerónimo Pachón, Ernest Giralt, Younes Smani
Preventing the adhesion of pathogens to host cells provides an innovative approach to tackling multidrug-resistant bacteria. In this regard, the identification of outer membrane protein A (OmpA) as a key bacterial virulence factor has been a major breakthrough. The use of virtual screening helped us to identify a cyclic hexapeptide AOA-2 that inhibits the adhesion of Acinetobacter baumannii, Pseudomonas aeruginosa and Escherichia coli to host cells and the formation of biofilm, thereby preventing the development of infection in vitro and in a murine sepsis peritoneal model...
October 31, 2017: Scientific Reports
Mario Martínez-Florensa, Marta Consuegra-Fernández, Fernando Aranda, Noelia Armiger-Borràs, Marianna Di Scala, Esther Carrasco, Jerónimo Pachón, Jordi Vila, Gloria González-Aseguinolaza, Francisco Lozano
No abstract text is available yet for this article.
November 2017: Antimicrobial Agents and Chemotherapy
Ángel Rodríguez-Villodres, José Manuel Ortiz de la Rosa, Rocío Álvarez-Marín, Jerónimo Pachón, Javier Aznar, José Antonio Lepe, Younes Smani
No abstract text is available yet for this article.
January 2018: Antimicrobial Agents and Chemotherapy
Antanina Voit, Vishwendra Patel, Ronald Pachon, Vikas Shah, Mohammad Bakhutma, Erik Kohlbrenner, Joseph J McArdle, Louis J Dell'Italia, Jerry R Mendell, Lai-Hua Xie, Roger J Hajjar, Dongsheng Duan, Diego Fraidenraich, Gopal J Babu
Sarcolipin (SLN) is an inhibitor of the sarco/endoplasmic reticulum (SR) Ca(2+) ATPase (SERCA) and is abnormally elevated in the muscle of Duchenne muscular dystrophy (DMD) patients and animal models. Here we show that reducing SLN levels ameliorates dystrophic pathology in the severe dystrophin/utrophin double mutant (mdx:utr (-/-)) mouse model of DMD. Germline inactivation of one allele of the SLN gene normalizes SLN expression, restores SERCA function, mitigates skeletal muscle and cardiac pathology, improves muscle regeneration, and extends the lifespan...
October 20, 2017: Nature Communications
Danielle Menosi Gualandro, Pai Ching Yu, Bruno Caramelli, André Coelho Marques, Daniela Calderaro, Luciana Savoy Fornari, Claudio Pinho, Alina Coutinho Rodrigues Feitosa, Carisi Anne Polanczyk, Carlos Eduardo Rochitte, Carlos Jardim, Carolina L Z Vieira, Debora Y M Nakamura, Denise Iezzi, Dirk Schreen, Eduardo Leal Adam, Elbio Antonio D'Amico, Emerson Q de Lima, Emmanuel de Almeida Burdmann, Enrique Indalecio Pachón Mateo, Fabiana Goulart Marcondes Braga, Fabio S Machado, Flavio J de Paula, Gabriel Assis Lopes do Carmo, Gilson Soares Feitosa-Filho, Gustavo Faibischew Prado, Heno Ferreira Lopes, João R C Fernandes, José J G de Lima, Luciana Sacilotto, Luciano Ferreira Drager, Luciano Janussi Vacanti, Luis Eduardo Paim Rohde, Luis F L Prada, Luis Henrique Wolff Gowdak, Marcelo Luiz Campos Vieira, Maristela Camargo Monachini, Milena Frota Macatrão-Costa, Milena Ribeiro Paixão, Mucio Tavares de Oliveira, Patricia Cury, Paula R Villaça, Pedro Silvio Farsky, Rinaldo F Siciliano, Roberto Henrique Heinisch, Rogerio Souza, Sandra F M Gualandro, Tarso Augusto Duenhas Accorsi, Wilson Mathias
No abstract text is available yet for this article.
January 2017: Arquivos Brasileiros de Cardiologia
Finn Akerström, Irene Narváez, Alberto Puchol, Marta Pachón, Cristina Martín-Sierra, Moisés Rodríguez-Mañero, Luis Rodríguez-Padial, Miguel A Arias
Aims: Multipoint pacing (MPP) permits simultaneous multisite pacing of the left ventricle (LV); initial studies suggest haemodynamic and clinical benefits over conventional (single LV site) cardiac resynchronization therapy (CRT). The aim of this study was to estimate the impact of MPP activation on battery longevity in routine clinical practice. Methods and results: Patient (n = 46) and device data were collected from two centres at least 3 months after MPP-CRT device implantation...
September 23, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
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