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https://www.readbyqxmd.com/read/28648215/erratum-to-renal-graft-survival-according-to-banff-2013-classification-in-indication-biopsies
#1
Carlos Arias-Cabrales, Dolores Redondo-Pachón, María José Pérez-Sáez, Javier Gimeno, Ignacio Sánchez-Güerri, Sheila Bermejo, Adriana Sierra, Carla Burballa, Marisa Mir, Marta Crespo, Julio Pascual
No abstract text is available yet for this article.
May 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28612405/a-comparative-transcriptomic-analysis-of-development-in-two-astyanax-cavefish-populations
#2
Bethany A Stahl, Joshua B Gross
Organisms that are isolated into extreme environments often evolve extreme phenotypes. However, global patterns of dynamic gene expression changes that accompany dramatic environmental changes remain largely unknown. The blind Mexican cavefish, Astyanax mexicanus, has evolved a number of severe cave-associated phenotypes including loss of vision and pigmentation, craniofacial bone fusions, increased fat storage, reduced sleep, and amplified nonvisual sensory systems. Interestingly, surface-dwelling forms have repeatedly entered different caves throughout Mexico, providing a natural set of "replicate" instances of cave isolation...
June 14, 2017: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
https://www.readbyqxmd.com/read/28595961/-flexible-bronchoscopy-in-octogenarians
#3
Antonio Noguera-Sánchez, María J Soler-Sempere, Justo Grau-Delgado, Lucía Zamora-Molina, Isabel Padilla-Navas, Eduardo García-Pachón
No abstract text is available yet for this article.
June 5, 2017: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/28585711/sudden-rhythm-change-in-dual-chamber-pacemaker-is-the-device-working-properly
#4
Miguel A Sastre, Finn Akerström, Marta Pachón, Alberto Puchol, Cristina Martín-Sierra, Marta Flores, Luis Rodríguez-Padial, Miguel A Arias
No abstract text is available yet for this article.
June 6, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28576545/-18-f-fdg-pet-ct-in-the-staging-of-alveolar-rhabdomyosarcoma
#5
Alvaro de Bonilla-Damiá, Rosa Fernández-López, Victor M Pachón-Garrudo, Catalina Márquez-Vega, Isabel Borrego-Dorado
No abstract text is available yet for this article.
May 30, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28558087/executive-summary-of-the-ii-brazilian-guidelines-for-atrial-fibrillation
#6
Luiz Pereira de Magalhães, Marcio Jansen de Oliveira Figueiredo, Fatima Dumas Cintra, Eduardo Benchimol Saad, Ricardo Ryoshim Kuniyoshi, Adalberto Menezes Lorga Filho, Andre Luiz Buchele D'Avila, Angelo Amato Vincenzo de Paola, Carlos Antonio Abunader Kalil, Dalmo Antonio Ribeiro Moreira, Dario Celestino Sobral Filho, Eduardo Back Sternick, Francisco Carlos da Costa Darrieux, Guilherme Fenelon, Gustavo Glotz de Lima, Jacob Atié, José Carlos Pachón Mateos, José Marcos Moreira, José Tarcísio Medeiros de Vasconcelos
No abstract text is available yet for this article.
December 2016: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28521337/perspectives-for-clinical-use-of-engineered-human-host-defense-antimicrobial-peptides
#7
María Eugenia Pachón-Ibáñez, Younes Smani, Jerónimo Pachón, Javier Sánchez-Céspedes
Infectious diseases caused by bacteria, viruses or fungi are among the leading causes of death worldwide. The emergence of drug-resistance mechanisms, especially among bacteria, threatens the efficacy of all current antimicrobial agents, some of them already ineffective. As a result, there is an urgent need for new antimicrobial drugs. Host defense antimicrobial peptides (HDPs) are natural occurring and well-conserved peptides of innate immunity, broadly active against Gram-negative and Gram-positive bacteria, viruses and fungi...
May 1, 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/28518147/survivin-a-key-player-in-cancer-progression-increases-in-obesity-and-protects-adipose-tissue-stem-cells-from-apoptosis
#8
Miriam Ejarque, Victòria Ceperuelo-Mallafré, Carolina Serena, Gisela Pachón, Yaiza Núñez-Álvarez, Margarida Terrón-Puig, Enrique Calvo, Catalina Núñez-Roa, Wilfredo Oliva-Olivera, Francisco J Tinahones, Miguel Angel Peinado, Joan Vendrell, Sonia Fernández-Veledo
Adipose tissue (AT) has a central role in obesity-related metabolic imbalance through the dysregulated production of cytokines and adipokines. In addition to its known risk for cardiovascular disease and diabetes, obesity is also a major risk for cancer. We investigated the impact of obesity for the expression of survivin, an antiapoptotic protein upregulated by adipokines and a diagnostic biomarker of tumor onset and recurrence. In a cross-sectional study of 111 subjects classified by body mass index, circulating levels of survivin and gene expression in subcutaneous AT were significantly higher in obese patients and positively correlated with leptin...
May 18, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28500387/thermal-adaptation-strategies-of-the-extremophile-bacterium-thermus-filiformis-based-on-multi-omics-analysis
#9
F Mandelli, M B Couger, D A A Paixão, C B Machado, C M Carnielli, J A Aricetti, I Polikarpov, R Prade, C Caldana, A F Paes Leme, A Z Mercadante, D M Riaño-Pachón, Fabio Marcio Squina
Thermus filiformis is an aerobic thermophilic bacterium isolated from a hot spring in New Zealand. The experimental study of the mechanisms of thermal adaptation is important to unveil response strategies of the microorganism to stress. In this study, the main pathways involved on T. filiformis thermoadaptation, as well as, thermozymes with potential biotechnological applications were revealed based on omics approaches. The strategy adopted in this study disclosed that pathways related to the carbohydrate metabolism were affected in response to thermoadaptation...
July 2017: Extremophiles: Life Under Extreme Conditions
https://www.readbyqxmd.com/read/28497342/exploration-of-the-acetylcholinesterase-inhibitory-activity-of-some-alkaloids-from-amaryllidaceae-family-by-molecular-docking-in-silico
#10
Willian O Castillo-Ordóñez, Elvira R Tamarozzi, Gabriel M da Silva, Andrés F Aristizabal-Pachón, Elza T Sakamoto-Hojo, Catarina S Takahashi, Silvana Giuliatti
Alzheimer's disease (AD) is a progressive condition, where dementia symptoms gradually worsen. Biochemically the disease is characterized by the presence of neuritic plaques, neurofibrillary tangles, in addition to cholinergic dysfunction in the central nervous system. The role of the cholinergic neurotransmission in AD is the basis of the widely accepted cholinergic hypothesis. Some of the most relevant therapies for the treatment of the disease are based on the acetylcholinesterase (AChE) inhibitor activity; however, these therapies are not effective to stop the disease progression, but only can temporarily slow down the worsening of dementia symptoms, and improve quality of life of patients and their caregivers...
May 11, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28497224/bone-density-microarchitecture-and-material-strength-in-chronic-kidney-disease-patients-at-the-time-of-kidney-transplantation
#11
M J Pérez-Sáez, S Herrera, D Prieto-Alhambra, L Vilaplana, X Nogués, M Vera, D Redondo-Pachón, M Mir, R Güerri, M Crespo, A Díez-Pérez, J Pascual
Bone health is assessed by bone mineral density (BMD). Other techniques such as trabecular bone score and microindentation could improve the risk of fracture's estimation. Our chronic kidney disease (CKD) patients presented worse bone health (density, microarchitecture, mechanical properties) than controls. More than BMD should be done to evaluate patients at risk of fracture. INTRODUCTION: BMD measured by dual-energy X-ray absorptiometry (DXA) is used to assess bone health in end-stage renal disease (ESRD) patients...
May 11, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28483170/-did-mozart-suffer-from-gilles-de-la-tourette-syndrome
#12
Leonardo Palacios-Sánchez, Juan Sebastián Botero-Meneses, Laura Daniela Vergara-Méndez, Natalia Pachón, Arianna Martínez, Santiago Ramírez
The personal and private lives of great men and women in history, like writers, painters and musicians, have been the subject of great interest for many years. A clear example of this is the vast scrutiny is cast over the famous composer, Wolfgang Amadeus Mozart. What may have started as curiosity, rapidly evolved into extensive research, as the answers about the musician's legendary talent may lie in the details of his life (his childhood, his relationships, his quirks and his mannerisms). It is usually up to historians, anthropologists or philosophers to delve into the pages of old books, trying to grasp answers and clues...
April 2017: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/28453834/overproduction-of-outer-membrane-protein-a-by-acinetobacter-baumannii-as-a-risk-factor-for-nosocomial-pneumonia-bacteremia-and-mortality-rate-increase
#13
Viviana Sánchez-Encinales, Rocío Álvarez-Marín, María Eugenia Pachón-Ibáñez, Felipe Fernández-Cuenca, Alvaro Pascual, José Garnacho-Montero, Luis Martínez-Martínez, Jordi Vila, María Mar Tomás, José Miguel Cisneros, Germán Bou, Jesús Rodríguez-Baño, Jerónimo Pachón, Younes Smani
Background.: Outer membrane protein A (OmpA) is a porin involved in Acinetobacter baumannii pathogenesis. However, OmpA clinical implication in hospital-acquired infections remains unknown. We aimed to determine whether OmpA overproduction was a risk factor associated with pneumonia, bacteremia, and mortality. Methods.: We analyzed demographic, microbiological, and clinical data from 100 patients included in a unicenter cohort and 246 included in a unicenter cohort and a multicenter cohort...
March 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28443966/miniaturized-transcatheter-leadless-pacemaker-in-a-patient-with-double-mechanical-prosthesis
#14
Marta Pachón, Alberto Puchol, Finn Akerström, Andrés Sánchez-Pérez, Miguel A Arias
No abstract text is available yet for this article.
March 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28411971/mdrd-or-ckd-epi-for-glomerular-filtration-rate-estimation-in-living-kidney-donors
#15
Carla Burballa, Marta Crespo, Dolores Redondo-Pachón, María José Pérez-Sáez, Marisa Mir, Carlos Arias-Cabrales, Albert Francés, Lluis Fumadó, Lluis Cecchini, Julio Pascual
INTRODUCTION: The evaluation of the measured Glomerular Filtration Rate (mGFR) or estimated Glomerular Filtration Rate (eGFR) is key in the proper assessment of the renal function of potential kidney donors. We aim to study the correlation between glomerular filtration rate estimation equations and the measured methods for determining renal function. MATERIAL AND METHODS: We analysed the relationship between baseline GFR values measured by Tc-(99)m-DTPA (diethylene-triamine-pentaacetate) and those estimated by the four-variable Modification of Diet in Renal Disease (MDRD4) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations in a series of living donors at our institution...
April 12, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28383704/ploidyngs-visually-exploring-ploidy-with-next-generation-sequencing-data
#16
Renato Augusto Corrêa Dos Santos, Gustavo Henrique Goldman, Diego Mauricio Riaño-Pachón
Summary: ploidyNGS is a model-free, open source tool to visualize and explore ploidy levels in a newly sequenced genome, exploiting short read data. We tested ploidyNGS using both simulated and real NGS data of the model yeast Saccharomyces cerevisiae. ploidyNGS allows the identification of the ploidy level of a newly sequenced genome in a visual way. Availability and implementation: ploidyNGS is available under the GNU General Public License (GPL) at https://github...
April 5, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28373284/pathogenic-acinetobacter-species-have-a-functional-type-i-secretion-system-and-contact-dependent-inhibition-systems
#17
Christian M Harding, Marina R Pulido, Gisela Di Venanzio, Rachel L Kinsella, Andrew I Webb, Nichollas E Scott, Jerónimo Pachón, Mario F Feldman
Pathogenic Acinetobacter species, including Acinetobacter baumannii and Acinetobacter nosocomialis, are opportunistic human pathogens of increasing relevance worldwide. Although their mechanisms of drug resistance are well studied, the virulence factors that govern Acinetobacter pathogenesis are incompletely characterized. Here we define the complete secretome of A. nosocomialis strain M2 in minimal medium and demonstrate that pathogenic Acinetobacter species produce both a functional type I secretion system (T1SS) and a contact-dependent inhibition (CDI) system...
June 2, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28361917/the-low-affinity-glucose-transporter-hxtb-is-also-involved-in-glucose-signalling-and-metabolism-in-aspergillus-nidulans
#18
Thaila Fernanda Dos Reis, Benjamin M Nitsche, Pollyne Borborema Almeida de Lima, Leandro José de Assis, Laura Mellado, Steven D Harris, Vera Meyer, Renato A Corrêa Dos Santos, Diego M Riaño-Pachón, Laure Nicolas Annick Ries, Gustavo H Goldman
One of the drawbacks during second-generation biofuel production from plant lignocellulosic biomass is the accumulation of glucose, the preferred carbon source of microorganisms, which causes the repression of hydrolytic enzyme secretion by industrially relevant filamentous fungi. Glucose sensing, subsequent transport and cellular signalling pathways have been barely elucidated in these organisms. This study therefore characterized the transcriptional response of the filamentous fungus Aspergillus nidulans to the presence of high and low glucose concentrations under continuous chemostat cultivation with the aim to identify novel factors involved in glucose sensing and signalling...
March 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28360170/draft-genome-sequence-of-saccharomyces-cerevisiae-barra-grande-bg-1-a-brazilian-industrial-bioethanol-producing-strain
#19
Natalia Coutouné, Aline Tieppo Nogueira Mulato, Diego Mauricio Riaño-Pachón, Juliana Velasco de Castro Oliveira
Here, we present the draft genome sequence of Saccharomyces cerevisiae BG-1, a Brazilian industrial strain widely used for bioethanol production from sugarcane. The 11.7-Mb genome sequence consists of 216 scaffolds and harbors 5,607 predicted protein-coding genes.
March 30, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28347776/identification-of-new-snps-associated-with-severe-toxicity-to-capecitabine
#20
Marta Pellicer, Xandra García-González, María I García, Luis Robles, Cristina Grávalos, Pilar García-Alfonso, Vanessa Pachón, Federico Longo, Virginia Martínez, Carolina Blanco, Irene Iglesias, María Sanjurjo, Luis A López-Fernández
Predicting individual risk of chemotherapy-induced severe adverse reaction is a critical issue when selecting the best treatment for cancer patients. SNPs have been identified in genes involved in the pharmacodynamics of fluoropyrimidines, and guidelines even recommend genotyping some DPYD variants in order to estimate the risk of toxicity. However, the predictive value of this approach remains insufficient, thus limiting its clinical implementation. The aim of the present study was to identify new genetic variants by selecting a group of tag SNPs in genes associated with the pharmacodynamics of fluoropyrimidines (CDA, DPYD, ENOSF1, CES1, TYMS, SLC22A7, TYMP, and UMPS)...
June 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
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