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https://www.readbyqxmd.com/read/29124773/consumption-of-orange-fermented-beverage-improves-antioxidant-status-and-reduces-peroxidation-lipid-and-inflammatory-markers-in-healthy-humans
#1
Blanca Escudero-López, Ángeles Ortega, Isabel Cerrillo, María-Rosario Rodríguez-Griñolo, Rocío Muñoz-Hernández, Hada C Macher, Franz Martín, Dámaso Hornero-Méndez, Pedro Mena, Daniele Del Rio, María-Soledad Fernández-Pachón
BACKGROUND: Alcoholic fermentation of fruits has generated novel products with high concentrations of bioactive compounds and moderate alcohol content. The aim of this study was to evaluate the potential effect on cardiovascular risk factors of the regular consumption by healthy humans of a beverage obtained by alcoholic fermentation and pasteurization of orange juice. RESULTS: Thirty healthy volunteers were enrolled in a randomized controlled study. The experimental group (n=15) drank 500 mL orange beverage (OB) day(-1) for 2 weeks (intervention phase), followed by a 3-week washout phase...
November 9, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29118851/targeted-metatranscriptomics-of-compost-derived-consortia-reveals-a-gh11-exerting-an-unusual-exo-1-4-%C3%AE-xylanase-activity
#2
Bruno L Mello, Anna M Alessi, Diego M Riaño-Pachón, Eduardo R deAzevedo, Francisco E G Guimarães, Melissa C Espirito Santo, Simon McQueen-Mason, Neil C Bruce, Igor Polikarpov
Background: Using globally abundant crop residues as a carbon source for energy generation and renewable chemicals production stand out as a promising solution to reduce current dependency on fossil fuels. In nature, such as in compost habitats, microbial communities efficiently degrade the available plant biomass using a diverse set of synergistic enzymes. However, deconstruction of lignocellulose remains a challenge for industry due to recalcitrant nature of the substrate and the inefficiency of the enzyme systems available, making the economic production of lignocellulosic biofuels difficult...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29089624/combating-virulence-of-gram-negative-bacilli-by-ompa-inhibition
#3
Xavier Vila-Farrés, Raquel Parra-Millán, Viviana Sánchez-Encinales, Monica Varese, Rafael Ayerbe-Algaba, Nuria Bayó, Salvador Guardiola, María Eugenia Pachón-Ibáñez, Martin Kotev, Jesús García, Meritxell Teixidó, Jordi Vila, Jerónimo Pachón, Ernest Giralt, Younes Smani
Preventing the adhesion of pathogens to host cells provides an innovative approach to tackling multidrug-resistant bacteria. In this regard, the identification of outer membrane protein A (OmpA) as a key bacterial virulence factor has been a major breakthrough. The use of virtual screening helped us to identify a cyclic hexapeptide AOA-2 that inhibits the adhesion of Acinetobacter baumannii, Pseudomonas aeruginosa and Escherichia coli to host cells and the formation of biofilm, thereby preventing the development of infection in vitro and in a murine sepsis peritoneal model...
October 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29066456/erratum-for-mart%C3%A3-nez-florensa-et-al-protective-effects-of-human-and-mouse-soluble-scavenger-like-cd6-lymphocyte-receptor-in-a-lethal-model-of-polymicrobial-sepsis
#4
Mario Martínez-Florensa, Marta Consuegra-Fernández, Fernando Aranda, Noelia Armiger-Borràs, Marianna Di Scala, Esther Carrasco, Jerónimo Pachón, Jordi Vila, Gloria González-Aseguinolaza, Francisco Lozano
No abstract text is available yet for this article.
November 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29061749/heteroresistance-to-piperacillin-tazobactam-in-clinical-isolates-of-escherichia-coli-st131
#5
Ángel Rodríguez-Villodres, José Manuel Ortiz de la Rosa, Rocío Álvarez-Marín, Jerónimo Pachón, Javier Aznar, José Antonio Lepe, Younes Smani
Heteroresistance to piperacillin/tazobactam has only been reported in Pseudomonas aeruginosa (1).….
October 23, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29051551/reducing-sarcolipin-expression-mitigates-duchenne-muscular-dystrophy-and-associated-cardiomyopathy-in-mice
#6
Antanina Voit, Vishwendra Patel, Ronald Pachon, Vikas Shah, Mohammad Bakhutma, Erik Kohlbrenner, Joseph J McArdle, Louis J Dell'Italia, Jerry R Mendell, Lai-Hua Xie, Roger J Hajjar, Dongsheng Duan, Diego Fraidenraich, Gopal J Babu
Sarcolipin (SLN) is an inhibitor of the sarco/endoplasmic reticulum (SR) Ca(2+) ATPase (SERCA) and is abnormally elevated in the muscle of Duchenne muscular dystrophy (DMD) patients and animal models. Here we show that reducing SLN levels ameliorates dystrophic pathology in the severe dystrophin/utrophin double mutant (mdx:utr (-/-)) mouse model of DMD. Germline inactivation of one allele of the SLN gene normalizes SLN expression, restores SERCA function, mitigates skeletal muscle and cardiac pathology, improves muscle regeneration, and extends the lifespan...
October 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/29044300/3rd-guideline-for-perioperative-cardiovascular-evaluation-of-the-brazilian-society-of-cardiology
#7
Danielle Menosi Gualandro, Pai Ching Yu, Bruno Caramelli, André Coelho Marques, Daniela Calderaro, Luciana Savoy Fornari, Claudio Pinho, Alina Coutinho Rodrigues Feitosa, Carisi Anne Polanczyk, Carlos Eduardo Rochitte, Carlos Jardim, Carolina L Z Vieira, Debora Y M Nakamura, Denise Iezzi, Dirk Schreen, Eduardo Leal Adam, Elbio Antonio D'Amico, Emerson Q de Lima, Emmanuel de Almeida Burdmann, Enrique Indalecio Pachón Mateo, Fabiana Goulart Marcondes Braga, Fabio S Machado, Flavio J de Paula, Gabriel Assis Lopes do Carmo, Gilson Soares Feitosa-Filho, Gustavo Faibischew Prado, Heno Ferreira Lopes, João R C Fernandes, José J G de Lima, Luciana Sacilotto, Luciano Ferreira Drager, Luciano Janussi Vacanti, Luis Eduardo Paim Rohde, Luis F L Prada, Luis Henrique Wolff Gowdak, Marcelo Luiz Campos Vieira, Maristela Camargo Monachini, Milena Frota Macatrão-Costa, Milena Ribeiro Paixão, Mucio Tavares de Oliveira, Patricia Cury, Paula R Villaça, Pedro Silvio Farsky, Rinaldo F Siciliano, Roberto Henrique Heinisch, Rogerio Souza, Sandra F M Gualandro, Tarso Augusto Duenhas Accorsi, Wilson Mathias
No abstract text is available yet for this article.
January 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29036370/estimation-of-the-effects-of-multipoint-pacing-on-battery-longevity-in-routine-clinical-practice
#8
Finn Akerström, Irene Narváez, Alberto Puchol, Marta Pachón, Cristina Martín-Sierra, Moisés Rodríguez-Mañero, Luis Rodríguez-Padial, Miguel A Arias
Aims: Multipoint pacing (MPP) permits simultaneous multisite pacing of the left ventricle (LV); initial studies suggest haemodynamic and clinical benefits over conventional (single LV site) cardiac resynchronization therapy (CRT). The aim of this study was to estimate the impact of MPP activation on battery longevity in routine clinical practice. Methods and results: Patient (n = 46) and device data were collected from two centres at least 3 months after MPP-CRT device implantation...
September 23, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28949089/treatment-of-chronic-antibody-mediated-rejection-with-intravenous-immunoglobulins-and-rituximab-a-multicenter-prospective-randomized-double-blind-clinical-trial
#9
Francesc Moreso, Marta Crespo, Juan C Ruiz, Armando Torres, Alex Gutierrez-Dalmau, Antonio Osuna, Manel Perelló, Julio Pascual, Irina B Torres, Dolores Redondo-Pachón, Emilio Rodrigo, Marcos Lopez-Hoyos, Daniel Seron
There are no approved treatments for chronic antibody mediated rejection (ABMR). We conducted a multicenter, prospective, randomized, placebo-controlled, double-blind clinical trial to evaluate efficacy and safety of intravenous immunoglobulins (IVIG) combined with rituximab (RTX) (EudraCT 2010-023746-67). Patients with transplant glomerulopathy and anti-HLA donor-specific antibodies (DSA) were eligible. Patients with estimated glomerular filtration rate (eGFR) <20 mL/min per 1.73m(2) and/or severe interstitial fibrosis/tubular atrophy were excluded...
September 26, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28890404/structural-and-functional-characterization-of-a-highly-secreted-%C3%AE-l-arabinofuranosidase-gh62-from-aspergillus-nidulans-grown-on-sugarcane-bagasse
#10
Fabiano Jares Contesini, Marcelo Vizoná Liberato, Marcelo Ventura Rubio, Felipe Calzado, Mariane Paludetti Zubieta, Diego Mauricio Riaño-Pachón, Fabio Marcio Squina, Fabricio Bracht, Munir S Skaf, André Ricardo Damasio
Carbohydrate-Active Enzymes are key enzymes for biomass-to-bioproducts conversion. α-l-Arabinofuranosidases that belong to the Glycoside Hydrolase family 62 (GH62) have important applications in biofuel production from plant biomass by hydrolyzing arabinoxylans, found in both the primary and secondary cell walls of plants. In this work, we identified a GH62 α-l-arabinofuranosidase (AnAbf62Awt) that was highly secreted when Aspergillus nidulans was cultivated on sugarcane bagasse. The gene AN7908 was cloned and transformed in A...
September 8, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28761423/galantamine-protects-against-beta-amyloid-peptide-induced-dna-damage-in-a-model-for-alzheimer-s-disease
#11
Willian O Castillo, Andres Felipe Aristizabal-Pachon
No abstract text is available yet for this article.
June 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28753224/aspergillus%C3%A2-fumigatus-protein-phosphatase-ppza-is-involved-in-iron-assimilation-secondary-metabolite-production-and-virulence
#12
Adriana Oliveira Manfiolli, Patrícia Alves de Castro, Thaila Fernanda Dos Reis, Stephen Dolan, Sean Doyle, Gary Jones, Diego M Riaño Pachón, Mevlüt Ulaş, Luke M Noble, Derek J Mattern, Axel A Brakhage, Vito Valiante, Rafael Silva-Rocha, Ozgur Bayram, Gustavo H Goldman
Metal restriction imposed by mammalian hosts during an infection is a common mechanism of defence to reduce or avoid the pathogen infection. Metals are essential for organism survival due to its involvement in several biological processes. Aspergillus fumigatus causes invasive aspergillosis, a disease that typically manifests in immunocompromised patients. A. fumigatus PpzA, the catalytic subunit of protein phosphatase Z (PPZ), has been recently identified as associated with iron assimilation. A. fumigatus has 2 high-affinity mechanisms of iron acquisition during infection: reductive iron assimilation and siderophore-mediated iron uptake...
July 28, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28745575/use-of-exome-sequencing-to-determine-the-full-profile-of-genetic-variants-in-the-fluoropyrimidine-pathway-in-colorectal-cancer-patients-affected-by-severe-toxicity
#13
Marta Pellicer, Xandra García-González, María I García, Carolina Blanco, Pilar García-Alfonso, Luis Robles, Cristina Grávalos, Daniel Rueda, Joaquín Martínez, Vanessa Pachón, Federico Longo, Virginia Martínez, Irene Iglesias, Sara Salvador, María Sanjurjo, Luis A López-Fernández
AIM: To identify genetic variants associated with capecitabine toxicity in fluoropyrimidine pathway genes using exome sequencing. PATIENTS & METHODS: Exomes from eight capecitabine-treated patients with severe adverse reactions (grade >2), among a population of 319, were sequenced (Ion Proton). SNPs in genes classified as potentially damaging (Sorting Intolerant from Tolerant and Polymorphism Phenotyping v2) were tested for association with toxicity in a validation cohort of 319 capecitabine-treated patients...
August 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28713559/draft-genome-sequencing-of-the-sugarcane-hybrid-sp80-3280
#14
Diego Mauricio Riaño-Pachón, Lucia Mattiello
Sugarcane commercial cultivar SP80-3280 has been used as a model for genomic analyses in Brazil. Here we present a draft genome sequence employing Illumina TruSeq Synthetic Long reads. The dataset is available from NCBI BioProject with accession PRJNA272769.
2017: F1000Research
https://www.readbyqxmd.com/read/28704740/comparative-assessment-of-selected-sugarcane-biorefinery-centered-systems-in-brazil-a-multi-criteria-method-based-on-sustainability-indicators
#15
Edgard Gnansounou, Catarina M Alves, Elia Ruiz Pachón, Pavel Vaskan
This work proposes a new sustainability assessment framework aiming to compare selected options of biorefineries subject to provide the same services to a community. At this end, a concept of biorefinery-centered system helps to develop a joint resources and policy-oriented comparison. When an option of biorefinery cannot provide the given amounts of certain services from its own production, it complements its supply portfolio by purchasing the lacking amounts from complementary and conventional production systems...
November 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28699977/pacemaker-implants-in-children-and-adolescents-with-chagas-disease-in-brazil-18-year-incidence
#16
Carolina Christianini Mizzaci, Thiago Gonçalves Schroder E Souza, Gabriel Pelegrineti Targueta, Ana Paula Frederico Tótora, Juan Carlos Pachón Mateos, José Carlos Pachon Mateos
Background: Chagas disease continues to be a serious public health problem, and accounts for 25-30% of the indications for cardiac stimulation in Brazil. Objective: To assess clinical and epidemiological characteristics of patients with Chagas disease, younger than 18 years, who had undergone pacemaker implantation in Brazil between 1994 and 2011, and its temporal trend. Methods: This was a cross-sectional analysis of data from the Brazilian Pacemaker Registry database...
June 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28699001/identification-classification-and-transcriptional-profiles-of-dirigent-domain-containing-proteins-in-sugarcane
#17
Paula Macedo Nobile, Alexandra Bottcher, Juliana L S Mayer, Michael S Brito, Ivan A Dos Anjos, Marcos Guimarães de Andrade Landell, Renato Vicentini, Silvana Creste, Diego Mauricio Riaño-Pachón, Paulo Mazzafera
Dirigent (DIR) proteins, encoded by DIR genes, are referred to as "dirigent" because they direct the outcome of the coupling of the monolignol coniferyl alcohol into (+) or (-) pinoresinol, the first intermediates in the enantiocomplementary pathways for lignan biosynthesis. DIR domain-containing or DIR-like proteins are, thus, termed for not having a clear characterization. A transcriptome- and genome-wide survey of DIR domain-containing proteins in sugarcane was carried out, in addition to phylogenetic, physicochemical and transcriptional analyses...
December 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28697549/deamidation-of-pseudopeptidic-molecular-hydrogelators-and-its-application-to-controlled-release
#18
César A Angulo-Pachón, Diego Navarro-Barreda, Celia M Rueda, Francisco Galindo, Juan F Miravet
HYPOTHESIS: The incorporation of a succinic acid-derived moiety in amino acid derivatives would favor an intramolecular catalysis of a deamidation reaction. Such reaction would permit controlled disassembly of molecular hydrogelators and the use of the hydrogels for controlled release of actives. EXPERIMENTAL: Low molecular weight hydrogelators containing a succinic acid-derived moiety were prepared by conventional organic synthesis procedures. Hydrogels were examined by electron microscopy and (1)HNMR studies were carried out to evaluate the solubility in water of the hydrogelators and the deamidation reaction...
November 1, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28666414/comparative-transcriptome-analysis-reveals-different-strategies-for-degradation-of-steam-exploded-sugarcane-bagasse-by-aspergillus-niger-and-trichoderma-reesei
#19
Gustavo Pagotto Borin, Camila Cristina Sanchez, Eliane Silva de Santana, Guilherme Keppe Zanini, Renato Augusto Corrêa Dos Santos, Angélica de Oliveira Pontes, Aline Tieppo de Souza, Roberta Maria Menegaldo Tavares Soares Dal'Mas, Diego Mauricio Riaño-Pachón, Gustavo Henrique Goldman, Juliana Velasco de Castro Oliveira
BACKGROUND: Second generation (2G) ethanol is produced by breaking down lignocellulosic biomass into fermentable sugars. In Brazil, sugarcane bagasse has been proposed as the lignocellulosic residue for this biofuel production. The enzymatic cocktails for the degradation of biomass-derived polysaccharides are mostly produced by fungi, such as Aspergillus niger and Trichoderma reesei. However, it is not yet fully understood how these microorganisms degrade plant biomass. In order to identify transcriptomic changes during steam-exploded bagasse (SEB) breakdown, we conducted a RNA-seq comparative transcriptome profiling of both fungi growing on SEB as carbon source...
June 30, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28648215/erratum-to-renal-graft-survival-according-to-banff-2013-classification-in-indication-biopsies
#20
Carlos Arias-Cabrales, Dolores Redondo-Pachón, María José Pérez-Sáez, Javier Gimeno, Ignacio Sánchez-Güerri, Sheila Bermejo, Adriana Sierra, Carla Burballa, Marisa Mir, Marta Crespo, Julio Pascual
No abstract text is available yet for this article.
May 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
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