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Transplant, renal allograft, renal stone

J Branchereau, R Thuret, F Kleinclauss, M-O Timsit
OBJECTIVES: To report epidemiology and characteristics of urinary lithiasis and its management in kidney allograft at the time of organ procurement or after kidney transplantation. MATERIAL AND METHODS: An exhaustive systematic review of the scientific literature was performed in the Medline database ( and Embase ( using different associations of the following keywords (MESH): urinary lithiasis, stone, kidney transplantation...
September 16, 2016: Progrès en Urologie
Burcin Ekser, Richard S Mangus, Chandrashekhar A Kubal, Jonathan A Fridell, John A Powelson, Santosh Nagaraju, Plamen Mihaylov, Carrie L Phillips, Romil Saxena, William C Goggins
BACKGROUND: Enteric hyperoxaluria (EH) occurs with a rate of 5-24% in patients with inflammatory bowel disease, ileal resection and modern bariatric surgery. The excessive absorption of calcium oxalate causes chronic kidney disease (CKD) in patients with EH. In the literature, a single experience was reported in combined intestine-kidney transplantation (CIKTx) in patients with CKD due to EH. METHODS: After a report of 2 successful cases of CIKTx in patients with EH and CKD, one was performed at our center in a 59-year-old Caucasian female who developed intestinal failure with total parenteral nutrition (TPN) dependence after a complication post-bariatric surgery...
2016: American Journal of Nephrology
Yusuke Okabayashi, Izumi Yamamoto, Yo Komatsuzaki, Takahito Niikura, Takafumi Yamakawa, Haruki Katsumata, Mayuko Kawabe, Ai Katsuma, Yasuyuki Nakada, Akimitsu Kobayashi, Yusuke Koike, Jun Miki, Hiroki Yamada, Yudo Tanno, Ichiro Ohkido, Nobuo Tsuboi, Kimiyoshi Ichida, Hiroyasu Yamamoto, Takashi Yokoo
We report a rare case of nephrocalcinosis caused by hereditary renal hypouricaemia 3 months after kidney transplantation. A 41-year-old man who underwent living-related kidney transplantation from his father was admitted to our hospital for a protocol biopsy; he had a serum creatinine (S-Cr) of 1.37 mg/dL and no proteinuria. Histologically, there was no evidence of rejection or calcineurin inhibitor toxicity, although scattered nephrocalcinosis was observed in the distal tubules. Perioperatively, the patient had a serum uric acid (S-UA) of 1...
July 2016: Nephrology
Guillaume Bollée, Pierre Cochat, Michel Daudon
PURPOSE OF REVIEW: To provide transplant physicians with a summary of the pathogenesis and diagnosis of adenine phosphoribosyl transferase (APRT) deficiency and primary hyperoxaluria and, focussed on kidney transplantation, and to discuss interventions aimed at preventing and treating the recurrence of crystalline nephropathy in renal transplant recipients. SOURCE OF INFORMATION: Pubmed literature search. SETTING: Primary hyperoxaluria and APRT deficiency are rare inborn errors of human metabolism...
2015: Canadian Journal of Kidney Health and Disease
M S Rezaee-Zavareh, R Ajudani, M Ramezani Binabaj, F Heydari, B Einollahi
BACKGROUND: It is said that renal transplantation lithiasis is rare. However, literature has some different frequencies in this field and most of the studies related to this issue are case reports. Also the exact effect of this complication on the graft survival rate is not clear. OBJECTIVES: To determine the prevalence of nephrolithiasis among kidney transplant recipients and evaluate its association with the graft survival. METHODS: We conducted a retrospective study to determine the prevalence of renal stone among 574 kidney transplant patients aged ≥18 years who had undergone renal transplantation in Baqiyatallah Transplant Center between 1990 and 2010...
2015: International Journal of Organ Transplantation Medicine
C Sevinc, M Balaban, O Ozkaptan, T Karadeniz
OBJECTIVE: To evaluate the safety and effectiveness of flexible ureterorenoscopy (F-URS) and laser lithotripsy for the treatment of allograft kidney lithiasis. PATIENTS AND METHODS: In a retrospective analysis of 897 consecutive renal transplantations that were performed at our center between February 2008 and December 2014, 6 patients were found to have allograft lithiasis. F-URS and laser lithotripsy were performed 6 times on 5 patients (twice for 1 patient who had stone recurrence after 6 months)...
July 2015: Transplantation Proceedings
Kristen McAlpine, Michael J Leveridge, Darren Beiko
Percutaneous nephrolithotomy (PCNL) is an established safe and effective surgical treatment option for renal calculi in renal allografts. The advent of tubeless PCNL has led to reports of ambulatory or outpatient PCNL. This case report describes the successful outpatient management of a 49-year-old female with a symptomatic renal pelvic calculus in her transplanted kidney. Tubeless PCNL successfully removed the stone, free of complication, and the patient was discharged 2 hours and 17 minutes after the procedure in stable condition with minimal pain...
May 2015: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
He-jia Yuan, Dian-dong Yang, Yuan-shan Cui, Chang-ping Men, Zhen-li Gao, L Shi, Ji-tao Wu
PURPOSE: Urolithiasis is a rare complication of renal transplantation, and there is limited evidence to guide treatment. Management of stones in the transplanted kidney can be challenging. We present our experience in treating upper urinary tract (UUT) allograft lithiasis using minimally invasive procedures, with the aim of demonstrating their efficacy and safety in renal transplant recipients. METHODS: The records of 1615 patients undergoing kidney transplantation and follow-up in our center between August 2000 and July 2014 were reviewed...
December 2015: World Journal of Urology
Riyadh Al-Sehli, Scott Grebe, Zija Jacaj, Siwei Chen, Stone Li, Kelly Craig, Valerie Luyckx, Thomas Mueller
BACKGROUND: Knowledge of an optimal expected serum creatinine (SCr) would be useful to detect early renal dysfunction after transplantation. Current measurements of posttransplant function rely on the recipient's SCr and calculations of estimated glomerular filtration rate (eGFR), based on recipient age, weight, and sex. Renal function after transplantation, however, also depends on the donor supply of functioning nephrons and adaptation in GFR of a single kidney. METHODS: We developed a formula to predict the optimal expected SCr after transplantation derived from donor and recipient Cockroft-Gault GFRs and adjusted for the single kidney adaptive response...
September 2015: Transplantation
G Mamarelis, S Vernadakis, D Moris, N Altanis, M Perdikouli, K Stravodimos, P Pappas, G Zavos
BACKGROUND AND PURPOSE: Urinary lithiasis represents an unusual urologic complication in renal transplantation, with an incidence of 0.17%-1.8%.We present our experience with renal graft lithiasis in our series of renal transplantations. MATERIAL AND METHODS: We reviewed the medical records for 2045 patients who underwent kidney transplantation from January 1983 to July 2013. Among the grafts, 9 patients were found to have allograft lithiasis. In 6 cases, the calculi were localized within the renal unit, and in 3 cases in the ureter...
November 2014: Transplantation Proceedings
Luis Romero-Vargas, Javier Barba Abad, David Rosell Costa, Juan Ignacio Pascual Piedrola
OBJECTIVE: To describe two clinical cases of staghorn stones in renal allografts and to perform a review of this condition. METHODS/RESULTS: Case 1. 71-year-old woman with a renal transplant and recurrent UTI presented lithiasis in the graft on renal ultrasound. We started medical treatment and later one ESWL session was performed. The subsequent evolution of the patient was bad, requiring transplant nephrectomy. Case 2. 68-year old woman with renal transplant presented acute deterioration of renal function due to staghorn stones...
September 2014: Archivos Españoles de Urología
Zongyao Hao, Li Zhang, Jun Zhou, Xiansheng Zhang, Haoqiang Shi, Yifei Zhang, Pengfei Wei, Chaozhao Liang
This report firstly describes an extremely rare case of repetitive double J stent calculi formation after renal transplantation caused by the antihyperparathyroidism (HPT) drug calcitriol. In 2012, a woman initially presented to our hospital for anuria with lower abdominal pain. She was diagnosed with allograft hydronephrosis and double J stents obstruction by calculi formation after transplantation and treated with triplicate stents replacements in another hospital without clinical manifestations improvements...
2014: Case Reports in Transplantation
Louise C McLoughlin, Niall F Davis, Catherine M Dowling, Richard E Power, Ponusamy Mohan, David P Hickey, Gordon P Smyth, Molly M P Eng, Dilly M Little
Renal transplantation in recipients with an ileal conduit is uncommon and occasionally controversial as it has been associated with high morbidity and mortality rates. We report on 17 patients with an ileal conduit who received a deceased donor renal transplant at our institution between January 1986 and December 2012. We retrospectively reviewed their allograft and surgical outcome. There were four mortalities at five, five, 39, and 66 months post-transplant. Sixteen of 17 grafts functioned immediately; one patient had primary non-function secondary to vascular thrombosis...
March 2014: Clinical Transplantation
Z G Ji, Y Tian, Y Q Chen, Z Liu, J Lin, J M Wang, L L Ma, H B Guo, Y W Tang, Z L Xie, W Sun, L Zhang
OBJECTIVE: To evaluate the safety and effectiveness of invasive percutaneous laser lithotripsy to manage allograft kidney lithiasis obstruction. METHODS: We treated 11 patients with kidney allograft lithiasis with minimally invasive percutaneous nephrolithotomy (mPCNL). RESULTS: All patients treated by mPCNL showed no residual stones thereafter. All subjects recovered successfully without major complications with improved renal function and reduced serum creatinine values...
November 2013: Transplantation Proceedings
N Elias, T Kawai, D S C Ko, R Saidi, N Tolkoff-Rubin, S Wicky, A B Cosimi, M Hertl
Type 1 primary hyperoxaluria (PH1) causes renal failure, for which isolated kidney transplantation (KT) is usually unsuccessful treatment due to early oxalate stone recurrence. Although hepatectomy and liver transplantation (LT) corrects PH1 enzymatic defect, simultaneous auxiliary partial liver transplantation (APLT) and KT have been suggested as an alternative approach. APLT advantages include preservation of the donor pool and retention of native liver function in the event of liver graft loss. However, APLT relative mass may be inadequate to correct the defect...
October 2013: American Journal of Transplantation
Catherine M Seager, Titte R Srinivas, Stuart M Flechner
BACKGROUND: Secondary hyperparathyroidism often accompanies chronic kidney disease, which can result in severe bone abnormalities and nephrolithiasis. Renal transplantation can correct the mineral abnormalities associated with chronic kidney disease, but one year after transplantation many recipients continue to exhibit persistent hyperparathyroidism. CASE REPORT: Cinacalcet, a second-generation calcimimetic, has been shown to be effective in decreasing serum calcium levels in post kidney transplant patients with hyperparathyroidism...
2013: Annals of Transplantation: Quarterly of the Polish Transplantation Society
S Saxena, H Sadideen, D Goldsmith
The formation of calculi in renal allografts is an uncommon complication in renal transplant recipients, with a reported incidence of 0.2-1.7% according to retrospective studies. Although the majority of these stones appear to form de novo following renal transplantation (RTX), there is a growing body of evidence suggesting that more often than previously thought they may be transplanted with the donor graft itself. The etiology and pathophysiology of renal graft stones is multifactorial. A combination of metabolic and urodynamic factors predispose to stone formation and these are generally found more frequently in allograft rather than native kidneys...
February 2013: Minerva Medica
Jonathon Olsburgh, Kay Thomas, Kathie Wong, Matthew Bultitude, Jonathan Glass, Giles Rottenberg, Lisa Silas, Rachel Hilton, Geoff Koffman
UNLABELLED: WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Previously, donors with asymptomatic stones found incidentally on CT were not considered ideal donor candidates because of the presumed risk of morbidity to both the donor and recipient. Increasingly, studies show that these risks are low. This study aims to evaluate the long-term safety of using ex vivo ureteroscopy to remove the stones from the donor kidney on the bench before donation. Outcomes so far suggest that this technique can safely render a kidney stone-free before transplantation...
May 2013: BJU International
Yasar Caliskan, Alaattin Yildiz
Due to organ shortage and difficulties for availability of cadaveric donors, living donor transplantation is an important choice for having allograft. Live donor surgery is elective and easier to organize prior to starting dialysis thereby permitting preemptive transplantation as compared to cadaveric transplantation. Because of superior results with living kidney transplantation, efforts including the usage of "Medically complex living donors" are made to increase the availability of organs for donation. The term "Complex living donor" is probably preferred for all suboptimal donors where decision-making is a problem due to lack of sound medical data or consensus guidelines...
2012: Journal of Transplantation
Konstantinos G Stravodimos, Stefanos Adamis, Stavros Tyritzis, Zavos Georgios, Constantinos A Constantinides
BACKGROUND AND PURPOSE: Renal transplant lithiasis represents a rather uncommon complication. Even rare, it can result in significant morbidity and a devastating loss of renal function if obstruction occurs. We present our experience with graft lithiasis in our series of renal transplantations and review the literature regarding the epidemiology, pathophysiology, and current therapeutic strategies in the management of renal transplant lithiasis. PATIENTS AND METHODS: In a retrospective analysis of a consecutive series of 1525 renal transplantations that were performed between January 1983 and March 2007, 7 patients were found to have allograft lithiasis...
January 2012: Journal of Endourology
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