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Duplex systems

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https://www.readbyqxmd.com/read/28929373/security-belt-for-wireless-implantable-medical-devices
#1
Selman Kulaç
In this study, a new protective design compatible with existing non-secure systems was proposed, since it is focused on the secure communication of wireless IMD systems in all transmissions. This new protector is an external wearable device and appears to be a belt fitted around for the patients IMD implanted. However, in order to provide effective full duplex transmissions and physical layer security, some sophisticated transceiver antennas have been placed on the belt. In this approach, beam-focused multi-antennas in optimal positions on the belt are randomly switched when transmissions to the IMD are performed and multi-jammer switching with MRC combining or majority-rule based receiving techniques are applied when transmissions from the IMD are carried out...
September 19, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28926069/rna-directed-off-on-switch-of-rnase-h-activity-using-boronic-ester-formation
#2
Maëva Reverte, Ivan Barvik, Jean-Jacques Vasseur, Michael Smietana
RNase H is a non-specific endonuclease which degrades selectively the RNA strand in DNA/RNA duplexes. We demonstrate in the present study that 5'-boronic acid modified oligonucleotides hybridized to a RNA target sequence converts RNase H to an inactivated enzyme complex. The dynamic formation of a boronate ester upon addition of a diol moiety disrupts the enzyme-inhibitor complex and reactivates RNase H. Moreover, we show that reactivation of RNase H function can also be engineered through short RNA trimers inputs that fashion RNase H from a non-specific DNA-guided enzyme into an informational and programmable RNA-guided one...
September 19, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28920942/exponential-growth-and-selection-in-self-replicating-materials-from-dna-origami-rafts
#3
Xiaojin He, Ruojie Sha, Rebecca Zhuo, Yongli Mi, Paul M Chaikin, Nadrian C Seeman
Self-replication and evolution under selective pressure are inherent phenomena in life, and but few artificial systems exhibit these phenomena. We have designed a system of DNA origami rafts that exponentially replicates a seed pattern, doubling the copies in each diurnal-like cycle of temperature and ultraviolet illumination, producing more than 7 million copies in 24 cycles. We demonstrate environmental selection in growing populations by incorporating pH-sensitive binding in two subpopulations. In one species, pH-sensitive triplex DNA bonds enable parent-daughter templating, while in the second species, triplex binding inhibits the formation of duplex DNA templating...
September 18, 2017: Nature Materials
https://www.readbyqxmd.com/read/28913864/strand-displacement-in-coiled-coil-structures-controlled-induction-and-reversal-of-proximity
#4
Katharina Gröger, Georgina Gavins, Oliver Seitz
Coiled-coil peptides are frequently used to create new function upon self-assembly of supramolecular complexes. A multitude of coil peptide sequences provides control over specificity and stability of coiled-coil complexes. However, comparably little attention has been paid to the development of methods that allow for the reversal of complex formation under non-denaturing conditions. Herein, we present a reversible 2-state switching system. The process involves two peptide molecules for formation of a size-mismatched coiled-coil duplex and a third, disruptor peptide which targets an overhanging end...
September 15, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28911109/selective-tumor-cell-death-induced-by-irradiated-riboflavin-through-recognizing-dna-g-t-mismatch
#5
Yi Yuan, Yongyun Zhao, Lianqi Chen, Jiasi Wu, Gangyi Chen, Sheng Li, Jiawei Zou, Rong Chen, Jian Wang, Fan Jiang, Zhuo Tang
Riboflavin (vitamin B2) has been thought to be a promising antitumoral agent in photodynamic therapy, though the further application of the method was limited by the unclear molecular mechanism. Our work reveals that riboflavin was able to recognize G-T mismatch specifically and induce single-strand breaks in duplex DNA targets efficiently under irradiation. In the presence of riboflavin, the photo-irradiation could induce the death of tumor cells that are defective in mismatch repair system selectively, highlighting the G-T mismatch as potential drug target for tumor cells...
September 6, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28900515/fluorocarbons-enhance-intracellular-delivery-of-short-stat3-sensors-and-enable-specific-imaging
#6
Valeriy Metelev, Surong Zhang, Shaokuan Zheng, Anand T N Kumar, Alexei Bogdanov
Short oligonucleotide sequences are now being widely investigated for their potential therapeutic properties. The modification of oligonucleotide termini with short fluorinated residues is capable of drastically altering their behavior in complex in vitro and in vivo systems, and thus may serve to greatly enhance their therapeutic potential. The main goals of our work were to explore: 1) how modification of STAT3 transcription factor-binding oligodeoxynucleotide (ODN) duplexes (ODND) with one or two short fluorocarbon (FC)-based residues would change their properties in vitro and in vivo, and if so, how this would affect their intracellular uptake by cancer cells, and 2) the ability of such modified ODND to form non-covalent complexes with FC-modified carrier macromolecule...
2017: Theranostics
https://www.readbyqxmd.com/read/28888402/investigating-the-potential-of-multiwalled-carbon-nanotubes-based-zinc-nanocomposite-as-a-recognition-interface-towards-plant-pathogen-detection
#7
Muhammad Ali Tahir, Sadaf Hameed, Anam Munawar, Imran Amin, Shahid Mansoor, Waheed S Khan, Sadia Zafar Bajwa
The emergence of nanotechnology has opened new horizons for constructing efficient recognition interfaces. This is the first report where the potential of a multiwalled carbon nanotube based zinc nanocomposite (MWCNTs-Zn NPs) investigated for the detection of an agricultural pathogen i.e. Chili leaf curl betasatellite (ChLCB). Atomic force microscope analyses revealed the presence of multiwalled carbon nanotubes (MWCNTs) having a diameter of 50-100nm with zinc nanoparticles (Zn-NPs) of 25-500nm. In this system, these bunches of Zn-NPs anchored along the whole lengths of MWCNTs were used for the immobilization of probe DNA strands...
September 6, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28886989/factors-associated-with-contralateral-deep-venous-thrombosis-after-iliocaval-venous-stenting
#8
S A Khairy, R J Neves, O Hartung, G J O'Sullivan
BACKGROUND: The majority of iliac venous obstructions occur on the left side, and endovascular therapy has become the first line treatment for this condition. A left common iliac venous stent will protrude into the inferior vena cava (IVC) to some extent, thereby covering the contralateral common iliac vein (CIV) outflow. This may increase the risk of thrombosis of the contralateral iliac vein. The aim of this paper was to determine the rate of, and factors associated with, contralateral lower limb venous thrombosis after stenting, and to evaluate the results of salvage revascularisation...
September 5, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28868629/afm-imaging-of-hybridization-chain-reaction-mediated-signal-transmission-between-two-dna-origami-structures
#9
Sarah Helmig, Kurt Vesterager Gothelf
Signal transfer is central to the controlled exchange of information in biology and advanced technologies. Therefore, the development of reliable, long-ranging signal transfer systems for artificial nanoscale assemblies is of great scientific interest. We have designed such a system for signal transfer between two connected DNA nanostructures, using the hybridization chain reaction (HCR). Two sets of metastable DNA hairpins - of which one is immobilized in specific points along tracks on DNA origami structures - are polymerized to form a continuous DNA duplex, which is visible using atomic force microscopy (AFM)...
September 3, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28868264/the-role-of-long-non-coding-rnas-in-the-repair-of-dna-double-strand-breaks
#10
REVIEW
Ali Dianatpour, Soudeh Ghafouri-Fard
DNA double strand breaks (DSBs) are abrasions caused in both strands of the DNA duplex following exposure to both exogenous and endogenous conditions. Such abrasions have deleterious effect in cells leading to genome rearrangements and cell death. A number of repair systems including homologous recombination (HR) and non-homologous end-joining (NHEJ) have been evolved to minimize the fatal effects of these lesions in cell. The role of protein coding genes in regulation of these pathways has been assessed previously...
2017: International Journal of Molecular and Cellular Medicine
https://www.readbyqxmd.com/read/28854778/nocturnal-leg-symptoms-are-not-associated-with-specific-patterns-of-superficial-venous-insufficiency
#11
Lisa F Fronek, Nisha J Bunke, Helane S Fronek
BACKGROUND: Certain nocturnal symptoms such as leg cramping (LC) and restless leg symptoms (RLS) are found in patients with venous disease.1 This study investigates the relationship between nocturnal symptoms and anatomic locations of superficial venous insufficiency. METHODS: A retrospective review of 371 consecutive patients presenting to a venous disease practice over a 1-year period was conducted. Patients underwent comprehensive assessment including standardized duplex scans...
August 30, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28840295/liver-function-quantified-by-limax-test-after-major-abdominal-surgery-comparison-between-open-and-laparoscopic-approach
#12
Magnus Kaffarnik, Gabriel Stoeger, Julia Liebich, Christian Grieser, Johann Pratschke, Martin Stockmann
INTRODUCTION: Major abdominal surgery may lead to a systemic inflammatory response (SIRS) with a risk of organ failure. One possible trigger for a postoperative hepatic dysfunction is an altered hepatic blood flow during SIRS, resulting in a decreased oxygen delivery. This pilot study investigated the role of liver dysfunction measured by the LiMAx test after major abdominal surgery, focussing on open and laparoscopic surgical approaches. METHODS: We prospectively investigated 25 patients (7 females and 18 males, age range 55-72 years) scheduled for upper abdominal surgery...
August 24, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28813152/coherent-exciton-delocalization-in-a-two-state-dna-templated-dye-aggregate-system
#13
Brittany L Cannon, Donald L Kellis, Lance K Patten, Paul H Davis, Jeunghoon Lee, Elton Graugnard, Bernard Yurke, William B Knowlton
Coherent exciton delocalization in dye aggregate systems gives rise to a variety of intriguing optical phenomena, including J- and H-aggregate behavior and Davydov splitting. Systems that exhibit coherent exciton delocalization at room temperature are of interest for the development of artificial light-harvesting devices, colorimetric detection schemes, and quantum computers. Here, we report on a simple dye system templated by DNA that exhibits tunable optical properties. At low salt and DNA concentrations, a DNA duplex with two internally functionalized Cy5 dyes (i...
September 6, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28810234/electrochemical-aptamer-based-nanosensor-fabricated-on-single-au-nanowire-electrodes-for-adenosine-triphosphate-assay
#14
Dongmei Wang, Xiaoqing Xiao, Shen Xu, Yong Liu, Yongxin Li
In this work, single Au nanowire electrodes (AuNWEs) were fabricated by laser-assisted pulling/hydrofluoric acid (HF) etching process, which then were characterized by transmission electron microscopy (TEM), electrochemical method and finite-element simulation. The as-prepared single AuNWEs were used to construct electrochemical aptamer-based nanosensors (E-AB nanosensors) based on the formation of Au-S bond that duplex DNA tagged with methylene blue (MB) was modified on the surface of electrode. In the presence of adenosine triphosphate (ATP), the MB-labeled aptamer dissociated from the duplex DNA due to the strong specific affinity between aptamer and target, which lead to the reduction of MB electrochemical signals...
August 9, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28809425/ph-responsive-quencher-free-molecular-beacon-systems-containing-2-deoxyuridine-units-labeled-with-fluorene-derivatives
#15
Ji Won Lee, Ye-Seul Son, Jun Yeon Hwang, Yoojin Park, Gil Tae Hwang
Three fluorescent nucleosides-U(FL), U(AF), and U(DAF), containing fluorene, 2-aminofluorene, and 2-dimethylaminofluorene units, respectively, covalently attached to 2'-deoxyuridine-have been incorporated into the central positions of oligodeoxynucleotides (ODNs) to examine the effects of their flanking bases (FBs) and pH on the emission properties upon hybridization with fully matched and single-base-mismatched targets. The ODN containing U(FL) and cytosine-FBs in the pH range from 5.5 to 8.0 and the ODN containing U(DAF) and cytosine-FBs under slightly acidic conditions (pH 6...
August 30, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28805877/a-dna-bipedal-nanowalker-with-a-piston-like-expulsion-stroke
#16
Q Y Yeo, I Y Loh, S R Tee, Y H Chiang, J Cheng, M H Liu, Z S Wang
Artificial molecular walkers beyond burn-bridge designs are important for nanotechnology, but their systematic development remains difficult. Herein, we have reported a new rationally designed DNA walker-track system and experimentally verified a previously proposed general expulsion regime for implementing non-burn-bridge nanowalkers. The DNA walker has an optically powered engine motif that reversibly extends and contracts the walker via a quadruplex-duplex conformational change. The walker's extension is an energy-absorbing and force-generating process, which drives the walker's leg dissociation off-track in a piston-like expulsion stroke...
August 24, 2017: Nanoscale
https://www.readbyqxmd.com/read/28798779/one-swallow-does-not-a-summer-make-but-many-swallows-do-accumulating-clinical-evidence-for-nearly-eliminated-peri-procedural-and-30-day-complications-with-mesh-covered-stents-transforms-the-carotid-revascularisation-field
#17
REVIEW
Piotr Musiałek, L Nelson Hopkins, Adnan H Siddiqui
Atherosclerotic carotid artery stenosis (CS) continues to be a common cause of acute ischaemic stroke. Optimised medical therapy (OMT), the first-line treatment modality in CS, may reduce or delay - but it does not abolish - CS-related strokes. As per current AHA/ASA and ESC/ESVS/ESO guidelines, carotid artery stenting (CAS) is a less-invasive alternative to carotid endarterectomy (CEA) for CS revascularisation in primary and secondary stroke prevention. Ten-year follow-up from the CREST trial in patients with symptomatic and asymptomatic CS confirmed equipoise of CAS and CEA in the primary endpoint...
2017: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/28798248/giant-hydronephrosis-in-a-case-of-ureterocele-with-duplex-system-an-entity-yet-not-reported
#18
Ruchir Aeron, Ashok Kumar Sokhal, Manoj Kumar, Satyanarayan Sankhwar
Ureterocele, which is a cystic dilatation of the terminal ureter, is usually associated with the upper moiety in a case of the duplex system. Giant hydronephrosis, a rare entity, is usually due to pelviureteric junction obstruction and is usually diagnosed in infants and children. We report a unique case of a unilateral complete duplex system with ureterocele with giant hydronephrosis of the upper moiety in an adult woman presenting as an abdominal lump. To the best of our knowledge, this is the first case of giant hydronephrosis associated with ureterocele in an adult patient...
August 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28795494/an-extended-high-frequency-ultrasound-protocol-for-detection-of-vessel-wall-inflammation
#19
H Zachrisson, C Svensson, A Dremetsika, P Eriksson
OBJECTIVE: The aim of this study was to evaluate an extended protocol of the large vessels using high-frequency duplex ultrasound (DUS) for detection of vessel wall inflammation. METHODS: Fifty-eight patients performed a DUS examination where arteritis could not be excluded. All DUS examinations were performed using ACUSON S2000 TM ultrasound system (Siemens Medical Solutions USA, Inc.). High-frequency linear transducers were used (18L6 MHz, 9L4MHz) or curve linear for the aortic arch (6C2 MHz)...
August 9, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28783358/long-range-ordering-of-blunt-ended-dna-tiles-on-supported-lipid-bilayers
#20
Nicole Avakyan, Justin W Conway, Hanadi F Sleiman
Long-range ordering of DNA crossover tiles with blunt ends on lipid bilayers is investigated using atomic force microscopy. "Blunt-ended" tiles do not have single-stranded complementary ends, and thus instead of assembling via base-pairing, they can interact by π-stacking of their duplex ends. This work demonstrates that the balance of base π-stacking interactions between the ends of DNA duplexes, cholesterol-mediated DNA anchoring, and electrostatic DNA binding to supported lipid bilayers (SLBs) presents an opportunity to build dynamic materials with long-range order on a soft support...
August 21, 2017: Journal of the American Chemical Society
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