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Caudal block

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https://www.readbyqxmd.com/read/29332115/ultrasound-guided-transversus-abdominis-plane-block-postoperative-analgesia-in-children-with-spinal-dysraphism
#1
Eralp Çevikkalp, Koray Erbüyün, Serpil Erbüyün, Gülay Ok
Pediatric regional anesthesia is widely used to relieve postoperative pain after abdominal surgery. Commonly used techniques of regional anesthesia include lumbar epidural and caudal block. However, the use of central neuraxial blockade has limitations. It is contraindicated in patients with clotting abnormalities, spinal dysraphism with tethered cord syndrome, meningomyelocele, and following spinal surgery with instrumentation. Ultrasound guided transversus abdominis plane block is a new method of regional anesthesia that can be used in settings where central neuraxial blockade is contraindicated...
January 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29320626/directing-nanoparticle-biodistribution-through-evasion-and-exploitation-of-stab2-dependent-nanoparticle-uptake
#2
Frederick Campbell, Frank L Bos, Sandro Sieber, Gabriela Arias-Alpizar, Bjørn E Koch, Jörg Huwyler, Alexander Kros, Jeroen Bussmann
Up to 99% of systemically administered nanoparticles are cleared through the liver. Within the liver, most nanoparticles are thought to be sequestered by macrophages (Kupffer cells), although significant nanoparticle interactions with other hepatic cells have also been observed. To achieve effective cell-specific targeting of drugs through nanoparticle encapsulation, improved mechanistic understanding of nanoparticle-liver interactions is required. Here, we show the caudal vein of the embryonic zebrafish (Danio rerio) can be used as a model for assessing nanoparticle interactions with mammalian liver sinusoidal (or scavenger) endothelial cells (SECs) and macrophages...
January 10, 2018: ACS Nano
https://www.readbyqxmd.com/read/29284865/comparison-of-analgesic-efficacy-of-caudal-dexamethasone-with-intravenous-dexamethasone-as-an-adjuvant-to-caudal-block-in-pediatric-patients-undergoing-urogenital-surgeries
#3
Dhanashree H Dongare, Seema S Karhade
Context: Caudal block is one of the most common regional anesthetic techniques employed in pediatric urogenital surgeries. Adjuvants play an important role to improve postoperative analgesia. Aims: The aim of this study was to evaluate the analgesic effect of dexamethasone when given systemically as against caudally as an adjuvant to caudal block. Subjects and Methods: In this randomized controlled study, sixty American Society of Anesthesiologists Physical Status I and II patients aged 3-6 years were randomly allocated into two groups of thirty each...
October 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29234953/involvement-of-microrna-23b-in-tnf-%C3%AE-reduced-bmsc-osteogenic-differentiation-via-targeting-runx2
#4
Lin Deng, Guoli Hu, Lei Jin, Chenglong Wang, Hongwen Niu
Elucidation of the molecular mechanism governing bone marrow mesenchymal stem cell (BMSC) osteogenic differentiation is of great importance for improving the treatment of osteoporosis. TNF-α is a well-known inhibitory factor during osteogenic differentiation of BMSCs. In our experiment, we consistently observed that TNF-α significantly inhibited BMSC osteogenic differentiation, which was partially rescued by BAY 11-7082 (NF-κB inhibitor). In this study, we examined the potential roles of microRNAs (miRNAs) involved in TNF-α-mediated reduction of BMSC osteogenesis...
December 12, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29234873/predictors-for-incidence-of-increased-time-spent-in-hospital-after-ambulatory-surgery-in-children-a-retrospective-cohort-study
#5
Takaya Nishida, Takahiro Mihara, Koui Ka
PURPOSE: Recently, pediatric ambulatory surgery has become common. However, for some of these patients, unplanned admission or prolonged hospital stay is also necessary, which can increase the mental burden on these patients. The aim of this study was to identify the predictors of the incidence of increased time spent in hospitals associated with pediatric ambulatory surgery. METHODS: Data were obtained from the medical and anesthetic records of 1087 consecutive patients aged < 18 years who underwent ambulatory surgery under general anesthesia...
December 12, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/29205687/ultrasound-guided-pudendal-nerve-block-in-children-a-new-technique-of-ultrasound-guided-transperineal-approach
#6
Isabelle Gaudet-Ferrand, Pablo De La Arena, Sophie Bringuier, Olivier Raux, Laurent Hertz, Nicolas Kalfa, Chrystelle Sola, Christophe Dadure
BACKGROUND: Transperineal pudendal nerve block guided by nerve stimulator is used in pediatric anesthesia as an alternative to caudal analgesia in perineal surgery. The risk of rectal puncture or intravascular injection is inherent to this blinded technique. We described a new technique of transperineal pudendal nerve block, with ultrasound guidance, to improve safety of the technique. AIMS: The first goal of this study was to describe this new technique and to test its feasibility...
December 5, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29184439/ultrasound-guided-rectus-sheath-block-caudal-analgesia-or-surgical-site-infiltration-for-pediatric-umbilical-herniorrhaphy-a-prospective-double-blinded-randomized-comparison-of-three-regional-anesthetic-techniques
#7
Lance M Relland, Joseph D Tobias, David Martin, Giorgio Veneziano, Ralph J Beltran, Christopher McKee, Tarun Bhalla
Background: Umbilical hernia repair is a common pediatric surgical procedure. While opioid analgesics are a feasible option and have long been a mainstay in the pharmacological intervention for pain, the effort to improve care and limit opioid-related adverse effects has led to the use of alternative techniques, including regional anesthesia. The current study prospectively compares the analgesic efficacy of three techniques, including caudal epidural blockade, peripheral nerve blockade, and local wound infiltration, in a double-blinded study...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29167004/-a-programmed-procedure-of-prosthetic-reconstruction-of-the-superior-vena-cava-%C3%A2-for-thoracic-tumors-via-median-thoracotomy
#8
Shijie Zhang, Xiangzheng Liu, Weiming Huang, Jian Li
BACKGROUND: The involvement of superior vena cava is a common condition in locally advanced thoracic tumors. Patients may benefit from the high risk operation. This study proposed a programmed procedure to optimize surgical techniques, which can facilitate the safety of operation via median thoracotomy. METHODS: A total of 35 patients with thoracic disease involved superior vena cava underwent prosthetic vascular reconstruction via median thoracotomy. All patients were confirmed locally advanced without distant metastasis including 16 pulmonary neoplasm and 19 mediastinal disease...
November 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29164530/ultrasound-guided-lateral-medial-transmuscular-quadratus-lumborum-block-for-analgesia-following-anterior-iliac-crest-bone-graft-harvesting-a-clinical-and-anatomical-study
#9
Rakesh V Sondekoppam, Vivian Ip, David F Johnston, Vishal Uppal, Marjorie Johnson, Sugantha Ganapathy, Ban C H Tsui
BACKGROUND: The anterior iliac crest (AIC) is one of the most common sites for harvesting autologous bone, but the associated postoperative pain can result in significant morbidity. Recently, the transmuscular quadratus lumborum block (TQL) has been described to anesthetize the thoraco-lumbar nerves. This study utilizes a combination of cadaveric models and clinical case studies to evaluate the dermatomal coverage and analgesic utility of TQL for AIC bone graft donor site analgesia. METHODS: Ten ultrasound-guided TQL injections were performed in five cadaver specimens using a lateral-to-medial transmuscular approach...
November 21, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29161549/ultrasound-guided-versus-conventional-injection-for-caudal-block-in-children-a-prospective-randomized-clinical-study
#10
Ali Ahiskalioglu, Ahmet Murat Yayik, Elif Oral Ahiskalioglu, Mursel Ekinci, Birzat Emre Gölboyu, Erkan Cem Celik, Haci Ahmet Alici, Akgun Oral, Saban Oguz Demirdogen
STUDY OBJECTIVE: The aim of this study was to compare the efficacies of ultrasound guided sacral hiatus injection and conventional sacral canal injection performed for caudal block in children. DESIGN: Randomized controlled clinical trial. SETTING: Operating rooms of university hospital of Erzurum, Turkey. PATIENTS: One hundred-thirty four children, American Society of Anesthesiologists I-II, between the ages of 5 and 12, scheduled for elective phimosis and circumcision surgery...
November 18, 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/29155191/ultrasound-guided-pudendal-block-is-a-viable-alternative-to-caudal-block-for-hypospadias-surgery-a-single-surgeon-pilot-study
#11
Sarah Hecht, Jorge Piñeda, Aaron Bayne
OBJECTIVE: To evaluate pudendal nerve block as an alternative to caudal block for hypospadias surgery. METHODS: Data were obtained by chart review. Children who underwent hypospadias repair between 2012 and 2016 by a single surgeon at an academic institution were included. Patients received ultrasound-guided pudendal block (n=21) or caudal block (n=19) as a regional adjunct to general anesthesia. Primary outcomes included analgesic requirement and postoperative length of stay in the recovery unit...
November 16, 2017: Urology
https://www.readbyqxmd.com/read/29126979/ropivacaine-and-bupivacaine-prevent-increased-pain-sensitivity-without-altering-neuroimmune-activation-following-repeated-social-defeat-stress
#12
Caroline M Sawicki, January K Kim, Michael D Weber, Brant L Jarrett, Jonathan P Godbout, John F Sheridan, Michelle Humeidan
OBJECTIVE: Mounting evidence indicates that stress influences the experience of pain. Exposure to psychosocial stress disrupts bi-directional communication pathways between the central nervous system and peripheral immune system, and can exacerbate the frequency and severity of pain experienced by stressed subjects. Repeated social defeat (RSD) is a murine model of psychosocial stress that recapitulates the immune and behavioral responses to stress observed in humans, including activation of stress-reactive neurocircuitry and increased pro-inflammatory cytokine production...
November 8, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29122625/comparison-of-intraoperative-and-early-postoperative-outcomes-of-caudal-versus-dorsal-penile-nerve-blocks-for-outpatient-penile-surgeries
#13
Katherine H Chan, Aali Shah, Elizabeth A Moser, Konrad Szymanski, Benjamin M Whittam, Rosalia Misseri, Martin Kaefer, Richard Rink, Mark P Cain
OBJECTIVE: To compare intraoperative and 1-hour postoperative outcomes in caudal versus dorsal penile nerve block (DPNB) patients undergoing penile surgeries. MATERIAL AND METHODS: We performed a retrospective cohort study of males <10 years old undergoing penile procedures (2013-2015) using the Pediatric Regional Anesthesia Network, Pediatric Health Information System databases and our medical records. The primary outcome was a maximum Faces Limbs Activity Crying Consolability pain score > 3...
November 6, 2017: Urology
https://www.readbyqxmd.com/read/29095712/ultrasound-guided-transversalis-fascia-plane-block-an-alternative-approach-for-anesthesia-in-inguinal-herniorrhaphy-a-case-report
#14
Paolo Scimia, Erika Basso Ricci, Emiliano Petrucci, Astrid Ursula Behr, Franco Marinangeli, Pierfrancesco Fusco
Ultrasound (US)-guided transversalis fascia plane block (TFPB) was first described by Hebbard as a technique for blockade of T12-L1 nerves. Although this technique appears similar to the quadratus lumborum 1 block, the point of injection is more caudal and anterior, specifically targeting ilioinguinal and iliohypogastric nerves. There are only few published data on US-guided TFPB demonstrating effective postoperative analgesia in iliac crest bone graft harvesting. We report the use of US-guided TFPB in a patient undergoing inguinal herniorrhaphy...
November 1, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/29033727/ultrasound-assessment-of-cranial-spread-during-caudal-blockade-in-children-effect-of-different-volumes-of-local-anesthetic
#15
Chandni Sinha, Amarjeet Kumar, Shalini Sharma, Akhilesh Kumar Singh, Somak Majumdar, Ajeet Kumar, Nishant Sahay, Bindey Kumar, U K Bhadani
BACKGROUND: Ultrasound-guided caudal block injection is a simple, safe, and effective method of anesthesia/analgesia in pediatric patients. The volume of caudal drug required has always been a matter of debate. MATERIALS AND METHODS: This present prospective, randomized, double-blinded study aimed to measure extent of the cranial spread of caudally administered levobupivacaine in Indian children by means of real-time ultrasonography. Ninety American Society of Anesthesiologists I/II children scheduled for urogenital surgeries were enrolled in this trial...
October 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/29028948/volumes-of-the-spinal-canal-and-caudal-space-in-children-zero-to-three-years-of-age-assessed-by-magnetic-resonance-imaging-implications-for-volume-dosage-of-caudal-blockade
#16
J Forestier, P Castillo, T Finnbogason, M Lundblad, S Eksborg, P A Lönnqvist
Background: The primary aim of this study was to objectively assess the different spinal and caudal volumes that are of interest for caudal block volume dosing. Methods: Three directly assessed (volume of spinal canal/caudal space, volume of the dural sac and volume of spinal cord) and two derived volumes (volume of the epidural space and cerebrospinal fluid volume) were determined from magnetic resonance images (MRI) in 20 children (zero - three yr of age). The assessed volumes were correlated to age, height and weight...
November 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28934796/decompressive-l5-transverse-processectomy-for-bertolotti-s-syndrome-a-preliminary-study
#17
Chang Il Ju, Seok Won Kim, Jong Gyue Kim, Seung Myung Lee, Ho Shin, Hyeun Young Lee
BACKGROUND: Bertolotti's syndrome is a spinal disorder characterized by abnormal enlargement of the transverse process of the most caudal lumbar vertebra. The L5 transverse process may be enlarged either unilaterally or bilaterally and may articulate or fuse with the sacrum or ilium. Pseudoarticulation between the transverse process of the L5 and the alar of the sacrum can cause buttock pain and leg pain. In addition, the L4 exiting nerve root could be compressed by an enlarged L5 transverse process...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28889964/hypotensive-effect-induced-by-microinjection-of-alamandine-a-derivative-of-angiotensin-1-7-into-caudal-ventrolateral-medulla-of-2k1c-hypertensive-rats
#18
E R Soares, C M Barbosa, M J Campagnole-Santos, R A S Santos, A C Alzamora
In the present study we evaluated the cardiovascular effects produced by microinjection of the new component of the renin-angiotensin system, alamandine, into caudal ventrolateral medulla of urethane-anesthetized normotensive and hypertensive 2K1C rats. The participation of different angiotensin receptors in the effects of alamandine was also evaluated. Microinjection of angiotensin-(1-7) was used for comparison. The microinjection of 4, 40 and 140pmol of alamandine or angiotensin-(1-7) into caudal ventrolateral medulla induced similar hypotensive effects in Sham-operated rats...
September 8, 2017: Peptides
https://www.readbyqxmd.com/read/28889155/comparison-of-3-different-regional-block-techniques-in-pediatric-patients-a-prospective-randomized-single-blinded-study
#19
Levent Sahin, Mahmut H Soydinc, Elzem Sen, Omer Cavus, Mehrican Sahin
To compare the analgesic efficiencies of caudal blocks, ultrasound (US)-guided transversus abdominis plane (TAP) blocks, and ilio-inguinal/ilio-hypogastric (II/IH) blocks performed to provide postoperative analgesia in pediatric patients undergoing unilateral lower abdominal surgery. Methods: This prospective, randomized, single-blinded study was conducted in the Department of Pediatric Surgery, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey from July 2013 to January 2015. The doses used were as follows: 0...
September 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28882370/caudal-epidural-anesthesia-in-mares-after-bicarbonate-addition-to-a-lidocaine-epinephrine-combination
#20
Patricia C Duarte, Cahuê F R Paz, Alvaro P L Oliveira, Thairê P Maróstica, Leticia O Cota, Rafael R Faleiros
OBJECTIVE: To investigate the nociceptive and clinical effects of buffering a lidocaine-epinephrine solution with sodium bicarbonate in caudal epidural block in mares. STUDY DESIGN: Prospective randomized controlled trial. ANIMALS: Six mixed-breed mares weighing 350-440 kg. METHODS: Each animal was administered two caudal epidural injections, 72 hours apart, using different solutions prepared immediately before injection...
January 11, 2017: Veterinary Anaesthesia and Analgesia
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