keyword
https://read.qxmd.com/read/36452711/efficacy-and-safety-of-diethylcarbamazine-in-treatment-of-allergic-rhinitis-a-double-blind-randomised-controlled-trial
#21
JOURNAL ARTICLE
S Mohana Karthikeyan, G N Nikisha
There are many evidences showing diethylcarbamazine as a potential drug for the treatment of allergic rhinitis. This study evaluated the effectiveness of diethylcarbamazine in the treatment of allergic rhinitis and compared it with montelukast and levocetirizine. This parallel double-blind randomized clinical trial was done in allergic rhinitis patients. Seven hundred and twelve participants who met the inclusion criteria and provided informed written consent were randomized and divided into 2 equal groups...
October 2022: Indian Journal of Otolaryngology and Head and Neck Surgery
https://read.qxmd.com/read/36421233/adverse-drug-reactions-adrs-of-montelukast-in-children
#22
JOURNAL ARTICLE
Abdullah Al-Shamrani, Saleh Alharbi, Sumayyah Kobeisy, Suzan A AlKhater, Haleimah Alalkami, Turki Alahmadi, Aisha Almutairi, Adel S Alharbi, Abdullah A Yousef
UNLABELLED: Montelukast is a leukotriene receptor antagonist (LTRA) commonly prescribed for asthma, allergic rhinitis and sleep-related breathing disorders. Recently, some studies have reported several adverse events, such as neuropsychiatric disorders and sleep disturbances, among children. OBJECTIVE: To obtain more insight into the safety profile of montelukast for children with asthma, allergic rhinitis and sleep-related breathing disorders. METHOD AND RESULTS: We retrospectively studied all adverse drug reactions to montelukast among 385 children 6 months or older in six tertiary centers over a two-year period...
November 21, 2022: Children
https://read.qxmd.com/read/36404692/-approaches-to-the-correction-of-auditory-tube-dysfunction-in-children-with-allergic-rhinitis
#23
JOURNAL ARTICLE
E P Merkulova, E A Baranaeva, N V Mikulchik, E S Bolshakova
UNLABELLED: Allergic diseases are a global public health problem. One of the most common among them is allergic rhinitis (AR), which affects up to 40% of adults and 2-25% of children. OBJECTIVE: To assess the state of ventilation of the middle ear in various forms of AR in children and the effectiveness of drug correction. MATERIAL AND METHODS: We conducted a comprehensive examination of 100 children with various forms of AR. The examination complex included the analysis of anamnestic data, the clinical picture of the disease, subjective otological symptoms, data from otoscopy, acoustic impedansometry and tonal threshold audiometry...
2022: Vestnik Otorinolaringologii
https://read.qxmd.com/read/36398245/effect-of-momethasone-furoate-combined-with-loratadine-and-montelukast-sodium-on-inflammatory-factors-and-pulmonary-function-in-children-with-allergic-rhinitis
#24
JOURNAL ARTICLE
Weili Dai, Ni Zhen, Xiaoyan Qin, Jingpeng Cao
OBJECTIVE: To compare the effects of mometasone furoate in combination with loratadine and montelukast sodium on inflammatory factors and pulmonary function in children with allergic rhinitis (AR). METHODS: In this retrospective study, a total of 89 children with AR admitted to our hospital from March 2020 to October 2021 were enrolled. Among them, 47 children who received mometasone furoate combined with loratadine were designated group A, while the other 42 with mometasone furoate combined with montelukast sodium were group B...
2022: American Journal of Translational Research
https://read.qxmd.com/read/36360335/increased-risk-of-tourette-syndrome-with-leukotriene-modifier-use-in-children-with-allergic-diseases-and-asthma-a-nationwide-population-based-study
#25
JOURNAL ARTICLE
Min-Lan Tsai, Hsiu-Chen Lin, Chiung-Hui Yen, Jung-Tzu Ku, Shian-Ying Sung, Hsi Chang
(1) Background: Cysteinyl leukotriene receptor antagonists (LTRAs), including montelukast and zafirlukast, are FDA-approved for treating pediatric asthma and allergic diseases. Tourette syndrome (TS), a common neuropsychiatric disorder in children, is associated with allergic diseases and asthma. In this study, we investigated the risk of TS following an LTRA prescription for pediatric allergic diseases. (2) Methods: Children younger than 18 years of age who were newly diagnosed with asthma, allergic rhinitis, or atopic dermatitis between 1 January 2005 and 31 December 2018 and who were registered in the Taiwan National Health Insurance Research Database, which comprises the medical records of nearly 23 million Taiwanese population, were enrolled...
October 22, 2022: Children
https://read.qxmd.com/read/36314138/survey-the-effect-of-drug-treatment-on-modulation-of-cytokines-gene-expression-in-allergic-rhinitis
#26
JOURNAL ARTICLE
Yan Ma, Xiao-Hong Yang, Yi Tu, Seyyed Shamsadin Athari
Allergic rhinitis as common airway disease has high prevalence in all peoples worldwide. In allergic diseases, Th2 cells release type 2 cytokines which support the inflammation in airways. All the drugs used for allergic rhinitis, do not cure completely, and the choice of drugs according to cost and efficacy is very important in all groups of atopic patients. Therefore, in this study, the effect of commercial drugs on cytokine gene expression has been studied. Male Balb/c mice were divided into six groups. Allergic rhinitis was induced in five of the six groups with ovalbumin, and four of these five groups were treated with salbutamol, budesonide, theophylline and montelukast...
October 31, 2022: Fundamental & Clinical Pharmacology
https://read.qxmd.com/read/36254546/torasemide-induced-vascular-purpura-in-the-course-of-eosinophilic-granulomatosis-with-polyangiitis
#27
JOURNAL ARTICLE
Aleksandra Frątczak, Karina Polak, Bartosz Miziołek, Beata Bergler-Czop
Torasemide is a loop diuretic with a molecule that is chemically similar to the sulphonamides described as eosinophilic granulomatosis with polyangiitis (EGPA) triggering drugs. The presented case is probably the first description of torasemide-induced vascular purpura in the course of EGPA. Any diagnosis of vasculitis should be followed by an identification of drugs that may aggravate the disease. A 74-year-old patient was admitted to the Department of Dermatology with purpura-like skin lesions on the upper, and lower extremities, including the buttocks...
September 2022: Acta Dermatovenerologica Croatica: ADC
https://read.qxmd.com/read/36213484/a-comparative-study-of-symptom-scores-in-patients-undergoing-posterior-lateral-nasal-neurectomy-with-medical-management-for-allergic-rhinitis
#28
JOURNAL ARTICLE
Lini Joseph, K C Prasad, S M Azeem Mohiyuddin
Allergic rhinitis is an IgE mediated reaction against inhaled allergens. Patients not responding to medical treatment require surgery. Most surgical procedures reduce erectile tissue of inferior turbinates. Vidian neurectomy reduces nasal hyperreactivity and secretions by reducing parasympathetic supply, but results in loss of lacrimation. Transnasal posterior nasal neurectomy is more selective denervation procedure which preserves lacrimation. There are few studies documenting the outcome of posterior lateral nasal neurectomy...
September 2022: Indian Journal of Otolaryngology and Head and Neck Surgery
https://read.qxmd.com/read/36209731/multicenter-prospective-observational-study-to-evaluate-the-therapeutic-effect-and-safety-of-a-combination-of-montelukast-and-levocetirizine-for-allergic-rhinitis-when-administered-to-patients-with-allergic-rhinitis-and-asthma
#29
JOURNAL ARTICLE
Min-Hye Kim, Kyoung-Hee Sohn, Hye Jung Park, Young Hee Nam, Mi-Hye Kim, Jae-Woo Jung, Jae-Woo Kwon, Yoo Seob Shin, Jong-Sook Park, Young-Joo Cho, Choon-Sik Park, Byoung Whui Choi
INTRODUCTION: Allergic rhinitis and asthma share a common inflammatory mechanism and are closely related, recognized as "one airway disease." Thus, the guidelines recommend allergic rhinitis and asthma be treated together, and leukotriene antagonists and antihistamines have been administered simultaneously; however, there are few reports of the use of combination drugs so far. METHODS: The aim of the study was to evaluate the treatment effects and adverse events of Monterizine® (a combination of montelukast and levocetirizine); a total of 2,254 patients with perennial allergic rhinitis and asthma were prospectively enrolled from 60 hospitals nationwide in Korea...
October 7, 2022: International Archives of Allergy and Immunology
https://read.qxmd.com/read/35963511/is-this-medication-safe-for-my-child-how-to-discuss-safety-of-commonly-used-medications-with-parents
#30
JOURNAL ARTICLE
David P Skoner, Alexandra K Golant, Allison E Norton, David R Stukus
All drugs have potential side effects, but thoughtful use can maximize benefits while minimizing risks. Children should not be considered just "small adults" regarding drug safety, as their growth and development are discordant with their ability to sense and self-report drug side effects. Detecting side effects requires vigilance and education from prescribers to parents, who are tasked with monitoring their child over time. A drug's safety profile is published in the package label after pivotal trials are conducted in relatively small and sometimes narrow segments of the population during the Food and Drug Administration approval process...
August 10, 2022: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/35608857/analysis-of-neuropsychiatric-diagnoses-after-montelukast-initiation
#31
JOURNAL ARTICLE
Tapio Paljarvi, Julian Forton, Sierra Luciano, Kimmo Herttua, Seena Fazel
IMPORTANCE: The evidence base for the association between montelukast and adverse neuropsychiatric outcomes is mixed and inconclusive. Several methodological limitations have been identified in the evidence base on the safety of montelukast in observational studies. OBJECTIVE: To investigate the association between new montelukast exposure and 1-year incident neuropsychiatric diagnoses with improved precision and control for baseline confounders. DESIGN, SETTING, AND PARTICIPANTS: This propensity score-matched cohort study was conducted using electronic health records from 2015 to 2019 in the TriNetX Analytics Network patient repository of more than 51 million patients from 56 health care organizations, mainly in the US...
May 2, 2022: JAMA Network Open
https://read.qxmd.com/read/35358494/montelukast-cysteinyl-leukotriene-receptor-1-antagonist-inhibits-cardiac-fibrosis-by-activating-apj
#32
JOURNAL ARTICLE
Yun Wu, Chen Cui, Fang-Fang Bi, Cheng-Yu Wu, Jin-Rui Li, Yu-Meng Hou, Ze-Hong Jing, Qing-Ming Pan, Miao Cao, Li-Fang Lv, Xue-Lian Li, Hong-Li Shan, Xin Zhai, Yu-Hong Zhou
Montelukast, cysteinyl leukotriene receptor 1 (CysLT1R) antagonist, is used clinically for patients with asthma, chronic obstructive pulmonary diseases (COPD), and allergic rhinitis. It has been reported that CysLT1R antagonists could reduce the risks of cardiovascular diseases in animal studies. Cardiac fibrosis is one of the major causes of heart failure. But little is known about the role of Montelukast in cardiac fibrosis and its underlying mechanism. In transverse aortic constriction (TAC) mice, Montelukast improved cardiac pumping function and inhibited cardiac fibrosis by down-regulation of the proteins related to the fibrosis, such as connective tissue growth factor (CTGF), Transforming Growth Factor β (TGF-β), and Alpha-smooth muscle actin (α-SMA)...
May 15, 2022: European Journal of Pharmacology
https://read.qxmd.com/read/35018845/daratumumab-infusion-reaction-rates-pre-and-post-addition-of-montelukast-to-pre-medications
#33
JOURNAL ARTICLE
Kelsey Coffman, Coby Carstens, Susan Fajardo
Daratumumab, a CD38-directed monoclonal antibody indicated for multiple myeloma treatment in adult patients, is associated with a high incidence of infusion-related reactions (IRRs). Due to CD38 receptor presence in the lungs, many reactions present similarly to asthma or allergic rhinitis. Montelukast, a leukotriene receptor antagonist, has been hypothesized to reduce daratumumab IRRs due to its efficacy in treating allergic rhinitis and asthma and the presence of leukotriene receptors in the lungs. Recently published data reported daratumumab can be safely administered via rapid rate protocol that reduces infusion time from 195 min to 90 min after completion of two doses...
March 2023: Journal of Oncology Pharmacy Practice
https://read.qxmd.com/read/34994006/stability-indicating-liquid-chromatography-method-development-and-validation-for-impurity-profiling-of-montelukast-sodium-in-bulk-drug-and-tablet-dosage-form
#34
JOURNAL ARTICLE
Mohan Pasham, Sharath Babu Haridasyam, N V V D Praveen Boppy, Muvvala Venkatanarayana, Ashok Kumar Palakurthi
Montelukast sodium (MLS) is a leukotriene receptor antagonist drug used in the treatment of asthma, bronchospasm, allergic rhinitis and urticaria. A reversed-phase high performance liquid chromatography method was developed to separate, identify and quantitative determination of MLS and its eight known organic impurities in tablet dosage form using a C18 column and mobile phases consisting of a gradient mixture of pH 2.5 phosphate buffer and acetonitrile. The stability-indicating character of the developed method was proven using stress testing (1 m HCl at 80°C/30 min, 1 m NaOH at 80°C/30 min, H2 O at 80°C/30 min, 3% H2 O2 at 25°C/1 min, dry heat at 105°C/10 h and UV-vis light/4 days) and was validated for specificity, quantitation limit, linearity, precision, accuracy and robustness...
April 2022: Biomedical Chromatography: BMC
https://read.qxmd.com/read/34920651/d-pinitol-attenuated-ovalbumin-induced-allergic-rhinitis-in-experimental-mice-via-balancing-th1-th2-response
#35
JOURNAL ARTICLE
Xiying You, Xiaopeng Sun, Junfei Kong, Jifeng Tian, Yanping Shi, Xia Li
Allergic rhinitis (AR) is a complex, chronic immunoinflammatory disorder of the membrane lining of the nasal mucosa. D-Pinitol is considered a cyclic polyol with a potential effect against various allergies. In the present study, we evaluated the anti-allergic effect of pinitol on ovalbumin (OVA)-induced AR model in mice. BALB/c mice were initially sensitized with an intraperitoneal injection of OVA and divided into 5 groups (n=18, in each group) for a treating schedule of distilled water (DW), montelukast (10 mg/kg), and pinitol (5, 10, and 20 mg/kg) through the mouth...
December 8, 2021: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/34904177/fda-warning-montelukast-03-2020-statement-of-the-austrian-working-group-of-pediatric-pulmonology-and-allergology
#36
JOURNAL ARTICLE
Anna Zschocke, Fritz Horak, Ernst Eber, Thomas Frischer, Burkhardt Simma, Wolfgang Stetzl, Josef Riedler, Zsolt Szépfalusi, Angela Zacharasiewicz
Montelukast, a leukotriene receptor antagonist (LTRA) has been approved for use in Europe since 1998. Indications for use (from the age of 6 months) include mild to moderate asthma, seasonal allergic rhinitis with asthma, and the prevention of exercise-induced asthma episodes. The psychiatric side effects of montelukast have been known for the last 10 years; in the case of such symptoms benefits and risks should be considered. Due to potential life-threatening psychiatric adverse events, particularly suicide, a black box warning was issued...
January 2022: Wiener Klinische Wochenschrift
https://read.qxmd.com/read/34725046/is-montelukast-monotherapy-effective-for-the-management-of-allergic-rhinitis-in-children
#37
JOURNAL ARTICLE
Chavini Ranasinghe, Jai Prashar
No abstract text is available yet for this article.
February 2022: Archives of Disease in Childhood
https://read.qxmd.com/read/34708419/ajwain-oil-attenuates-allergic-response-of-ovalbumin-induced-allergic-rhinitis-via-alteration-of-inflammatory-oxidative-stress-and-th1-th2-responses
#38
JOURNAL ARTICLE
Jingjing Li, Prashant Raghav, Chunyan Hu
BACKGROUND: Allergic rhinitis (AR) is an immune inflammatory-related disorder that affects the nasal mucosa. Free radicals play a crucial role in the expansion of allergic reaction and the researcher used the antioxidant therapy to treat the disease. Trachyspermum ammi L. (Ajwain oil) is popular traditional medicine. It has been proved their potential effect on various diseases. Ajwain oil showed anti-tumor, antioxidant, antidiabetic, anti-inflammatory, and anti-bacterial properties. Yet, the anti-allergic effect of Ajwain oil is still not explored...
December 2021: Journal of Food Biochemistry
https://read.qxmd.com/read/34613593/treatment-of-pediatric-mild-persistent-asthma-with-low-dose-budesonide-inhalation-suspension-vs-montelukast-in-china
#39
JOURNAL ARTICLE
Zhi-Min Chen, De-Yu Zhao, Li Xiang, Jian-Guo Hong
BACKGROUND: There are limited studies comparing budesonide inhalation suspension (BIS) with montelukast in real-world settings where treatment adherence and persistency may be suboptimal. This real-world study aims to investigate the control effectiveness of montelukast or BIS as a monotherapy in Chinese children with mild asthma. METHODS: Data were derived from a retrospective questionnaire-based analysis of 2‒14-year-old children with mild persistent asthma, who received either 500 µg of BIS (n = 153) or 4‒5 mg of montelukast (n = 240) once daily...
December 2021: World Journal of Pediatrics: WJP
https://read.qxmd.com/read/34565285/montelukast-attenuates-interleukin-il-1%C3%AE-induced-oxidative-stress-and-apoptosis-in-chondrocytes-by-inhibiting-cysltr1-cysteinyl-leukotriene-receptor-1-and-activating-klf2-kruppel-like-factor-2
#40
JOURNAL ARTICLE
Zongwei Li, Jianming Wang, Yumin Ma
Montelukast is a cysteinyl leukotriene receptor 1 (CysLTR1) antagonist widely used to suppress the inflammatory response in asthma and allergic rhinitis. This study aimed to investigate the potential impacts of montelukast on osteoarthritis (OA) progression. To determine the role of montelukast in OA, the expression of CysLTR1 was first examined by quantitative reverse transcription PCR (RT-qPCR) and western blot in IL-1β-induced ATDC5 cells treated with or without montelukast. Subsequently, the impacts of montelukast on cell viability and oxidative stress were measured by Cell-Counting-Kit-8 (CCK-8), commercial kits and western blot...
December 2021: Bioengineered
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