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Human papillomavirus testing

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https://www.readbyqxmd.com/read/29349795/quality-of-life-assumptions-determine-which-cervical-cancer-screening-strategies-are-cost-effective
#1
Inge M C M de Kok, Ida J Korfage, Wilbert B van den Hout, Theo J M Helmerhorst, J Dik F Habbema, Marie-Louise Essink-Bot, Marjolein van Ballegooijen
Quality adjusted life years are used in cost-effectiveness analyses (CEAs). To calculate QALYs, a 'utility' (0-1) is used for each health state induced or prevented by the intervention. We aimed to estimate the impact of quality-of-life (QoL) assumptions (utilities and durations of health states) on CEAs of cervical cancer screening. To do so, twelve alternative sets of utility assumptions were retrieved from published cervical cancer screening CEAs. Two additional sets were based on empirical QoL data that were integrally obtained through two different measures (SF-6D and EQ-5D) from eight groups of women (total n= 3,087), from invitation for screening to diagnosis with cervical cancer...
January 19, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29344860/laser-microdissection-for-human-papillomavirus-hpv-genotyping-attribution-and-methylation-pattern-analyses-of-squamous-intraepithelial-lesions
#2
Monica Molano, Suzanne M Garland, Alyssa M Cornall
Human papillomavirus (HPV) is a nearly ubiquitous infectious organism. It is estimated that 80% of sexually active adults will be exposed to anogenital HPVs in their lifetime, and detection of multiple genotypes in an anogenital sample is common. Detection and genotyping of HPV is usually performed by DNA testing, and less frequently by mRNA testing. HPV genotype testing and characterization of DNA methylation patterns of HPV-related lesions can provide important biological, epidemiological, and potentially relevant clinical information in individuals and populations...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29344635/eradication-of-cervical-cancer-in-vivo-by-an-aav-vector-that-encodes-shrna-targeting-human-papillomavirus-type-16%C3%A2-e6-e7
#3
Naoto Sato, Yasushi Saga, Ryosuke Uchibori, Tomonori Tsukahara, Masashi Urabe, Akihiro Kume, Hiroyuki Fujiwara, Mitsuaki Suzuki, Keiya Ozawa, Hiroaki Mizukami
The major causative agent of cervical cancer is human papilloma virus (HPV); the viral proteins E6 and E7 induce carcinogenesis through the inactivation of the host tumor-suppressor gene. Therefore, the stable expression of specific inhibitors of E6 and E7 in cancer cells is expected to provide effective treatment for cervical cancer without affecting normal tissue. In this study, we propose a novel therapeutic approach using an adeno-associated virus (AAV) vector encoding short hairpin RNA (shRNA) against the oncoproteins E6 and E7 (shE6E7) of HPV type 16 (HPV‑16), termed AAV‑shE6E7...
January 15, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29344211/prevalence-of-hpv-infection-among-hiv-positive-and-hiv-negative-women-in-central-eastern-italy-strategies-of-prevention
#4
Edoardo Tartaglia, Katia Falasca, Jacopo Vecchiet, Giovanna Paola Sabusco, Giovanna Picciano, Roberto Di Marco, Claudio Ucciferri
The present cross-sectional-study aimed to determine the prevalence of human papillomavirus (HPV)-genotypes among human immunodeficiency virus (HIV)-positive and -negative women in Central/Eastern Italy, and to identify the optimal strategies for effective HPV-prevention in each group. A representative sample of HIV-negative (150/200) and -positive (50/200) women, who underwent cervico-vaginal-swabbing. Swabs were analysed for a cytological screening and for a HPV-DNA-genotyping-test. A total of 66/200 swabs resulted HPV-positive...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29344081/hpv-infection-and-p16-expression-in-oral-and-oropharyngeal-cancer-in-kazakhstan
#5
Dauren Adilbay, Galim Adilbayev, Gulzhan Kidirbayeva, Viktoria Shipilova, Zhanat Sadyk, Gulsum Koyanbekova, Ekaterina Sokolenko, Jan Klozar
Background: Human papillomavirus (HPV) is an important etiologic factor in different cancers of anogenital region and also in a fraction of head and neck cancers (HNC) particularly oropharyngeal tumors. The HPV16 genotype associated with the majority of HPV-related head and neck carcinomas. Th incidence of oropharyngeal cancer is increasing in many countries, and the rate of HPV positive tumors is about 70% in Europe and North America. Little known about the prevalence of HPV in HNC in Central Asia...
2018: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29335156/adapting-cervical-cancer-screening-for-women-vaccinated-against-human-papillomavirus-infections-the-value-of-stratifying-guidelines
#6
Kine Pedersen, Emily A Burger, Mari Nygård, Ivar S Kristiansen, Jane J Kim
BACKGROUND: Several countries have implemented vaccination against human papillomavirus (HPV) for adolescent girls and must decide whether and how to adapt cervical cancer (CC) screening for these low-risk women. We aimed to identify the optimal screening strategies for women vaccinated against HPV infections and quantify the amount that could be spent to identify vaccination status among women and stratify CC screening guidelines accordingly. METHODS: We used a mathematical model reflecting HPV-induced CC in Norway to project the long-term health benefits, resources and costs associated with 74 candidate-screening strategies that varied by screening test, start age and frequency...
January 12, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29334204/detection-of-chlamydia-trachomatis-in-pap-smear-samples-from-south-khorasan-province-of-iran
#7
Davod Javanmard, Mahmoodreza Behravan, Malaknaz Ghannadkafi, Alireza Salehabadi, Masood Ziaee, Mohammad Hasan Namaei
Background: Chlamydia trachomatis (CT), the most common bacterial sexually transmitted infection (STI), leads to pelvic inflammatory disease, infertility and chronic pelvic pain in women as well as an increased risk of vertical transmission, conjunctivitis and pneumonitis in infants. It may also be a co-factor along with human papillomavirus (HPV) in cervical cancer progression. We aimed to determine the prevalence of CT genotypes in genital specimens of women from South Khorasan, Iran and to test the association between CT and cytology statistics...
April 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29331245/outsmart-hpv-acceptability-and-short-term-effects-of-a-web-based-hpv-vaccination-intervention-for-young-adult-gay-and-bisexual-men
#8
Annie-Laurie McRee, Abigail Shoben, Jose A Bauermeister, Mira L Katz, Electra D Paskett, Paul L Reiter
BACKGROUND: Effective interventions to promote human papillomavirus (HPV) vaccination are needed, particularly among populations at increased risk of HPV-related disease. We developed and pilot tested a web-based intervention, Outsmart HPV, to promote HPV vaccination among young gay and bisexual men (YGBM). METHODS: In 2016, we recruited a national sample (n = 150) of YGBM ages 18-25 in the United States who had not received any doses of HPV vaccine. Participants were randomized to receive either standard HPV vaccination information (control) or population-targeted, individually-tailored content (Outsmart HPV intervention)...
January 10, 2018: Vaccine
https://www.readbyqxmd.com/read/29328473/detection-of-high-grade-neoplasia-in-air-dried-cervical-pap-smears-by-a-microrna-based-classifier
#9
Mikhail K Ivanov, Sergei E Titov, Sergei A Glushkov, Victoria V Dzyubenko, Anastasia V Malek, Polina A Arkhangelskaya, Roman B Samsonov, Andrey A Mikhetko, Elena V Bakhidze, Igor V Berlev, Nikolay N Kolesnikov
Recent studies have shown that changes in the expression levels of certain microRNAs correlate with the degree of severity of cervical lesions. The aim of the present study was to develop a microRNA-based classifier for the detection of high-grade cervical intraepithelial neoplasia (CIN ≥2) in cytological samples from patients with different high-risk human papillomavirus (HR-HPV) viral loads. For this purpose, raw RT-qPCR data for 25 candidate microRNAs, U6 snRNA and human DNA in air-dried PAP smears from 174 women with different cervical cytological diagnoses, 144 of which were HR-HPV-positive [40 negative for intraepithelial lesion or malignancy (NILM), 34 low-grade squamous intraepithelial lesions (L-SIL), 57 high-grade squamous intraepithelial lesions (H-SIL), 43 invasive cancers], were statistically processed...
January 12, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29327232/comparative-evaluation-of-the-omniplex-hpv-and-rfmp-hpv-papillotyper-for-detecting-human-papillomavirus-genotypes-in-cervical-specimens
#10
Young Ahn Yoon, Bo-Hyun Kim, Su-Hak Heo, Hwi Jun Kim, Young-Jin Choi
Human papillomavirus (HPV) is a major cause of cervical neoplasia development. HPV screening is very important because early treatment can prevent cervical cancer. Omniplex-HPV is a polymerase chain reaction followed by Luminex xMAP bead microarray technology that is designed for detecting 40 HPV genotypes. The aim of this study is to evaluate the analytical and clinical performance of the Omniplex-HPV in comparison with that of the commercially available RFMP (restriction fragment mass polymorphism) HPV PapilloTyper...
January 11, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29326178/impact-of-replacing-cytology-with-human-papillomavirus-testing-for-cervical-cancer-screening-on-the-prevalence-of-trichomonas-vaginalis-a-modelling-study
#11
Ben B Hui, Caitlin P Reulein, Rebecca J Guy, Basil Donovan, Jane S Hocking, Matthew G Law, David G Regan
OBJECTIVES: Trichomonas vaginalis (TV) is the most common curable STI worldwide and is associated with increased risk of HIV acquisition and serious reproductive morbidities. The prevalence of TV infection is very low in Australian cities, and this is thought to be at least partly due to incidental detection and treatment of TV in women participating in the cervical cytology screening programme. In 2017, the national cervical screening programme will transition to a new model based on testing for high-risk (HR) human papillomavirus (HPV), with a reduced frequency and commencement at an older age...
January 11, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29322839/feasibility-study-of-a-human-papillomavirus-e6-and-e7-oncoprotein-test-for-the-diagnosis-of-cervical-precancer-and-cancer
#12
Jin-Jun Zhang, Xin-Chun Cao, Xiang-Yu Zheng, Hai-Ying Wang, Yong-Wei Li
Objective To evaluate the clinical value of human papillomavirus (HPV) E6 and E7 oncoprotein (HPV E6/E7) detection in the early screening of cervical cancer. Methods This prospective study evaluated all patients with suspected cervical intraepithelial neoplasia (CIN) as identified by the presence of at least one positive indicator from a ThinPrep cytologic test (TCT) and/or a Hybrid Capture 2 (HC2) HPV DNA test. The levels of E6/E7 oncoproteins were determined using Western blot analysis. The diagnostic value of the HPV E6/E7 protein assay was compared with the clinical diagnosis from TCT, HC2 and the gold standard of cervical biopsy histology...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29310590/oral-human-papillomavirus-dna-detection-in-hiv-positive-men-prevalence-predictors-and-co-occurrence-at-anal-site
#13
Alessandra Vergori, Anna Rosa Garbuglia, Pierluca Piselli, Franca Del Nonno, Catia Sias, Federico Lupi, Daniele Lapa, Andrea Baiocchini, Claudia Cimaglia, Marco Gentile, Andrea Antinori, Maria Capobianchi, Adriana Ammassari
BACKGROUND: HIV-positive patients carry an increased risk of HPV infection and associated cancers. Therefore, prevalence and patterns of HPV infection at different anatomical sites, as well as theoretical protection of nonavalent vaccine should be investigated. Aim was to describe prevalence and predictors of oral HPV detection in HIV-positive men, with attention to nonavalent vaccine-targeted HPV types. Further, co-occurrence of HPV DNA at oral cavity and at anal site was assessed. METHODS: This cross-sectional, clinic-based study included 305 HIV-positive males (85...
January 8, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29307386/prediction-of-cervical-cancer-incidence-in-england-uk-up-to-2040-under-four-scenarios-a-modelling-study
#14
Alejandra Castanon, Rebecca Landy, Francesca Pesola, Peter Windridge, Peter Sasieni
BACKGROUND: In the next 25 years, the epidemiology of cervical cancer in England, UK, will change: human papillomavirus (HPV) screening will be the primary test for cervical cancer. Additionally, the proportion of women screened regularly is decreasing and women who received the HPV vaccine are due to attend screening for the first time. Therefore, we aimed to estimate how vaccination against HPV, changes to the screening test, and falling screening coverage will affect cervical cancer incidence in England up to 2040...
January 2018: Lancet. Public Health
https://www.readbyqxmd.com/read/29302852/acceptability-of-self-sample-human-papillomavirus-testing-among-thai-women-visiting-a-colposcopy-clinic
#15
Natacha Phoolcharoen, Nuttavut Kantathavorn, Wasanai Krisorakun, Chantanee Taepisitpong, Waraphorn Krongthong, Siriporn Saeloo
We offered self-sampling devices to 250 women who visited the colposcopy clinic at Chulabhorn Hospital, Bangkok, Thailand from March 1 to June 30, 2015. Participants received instruction about the vaginal self-sample method and collected the specimen themselves, before being examined by the physician who obtained a conventional cervical specimen. Participating women's attitudes and feelings regarding the self-sample method were explored using a short questionnaire. Of the 247 eligible women, more than 90% of participants rated the self-sample method as very good to excellent for convenience, comfort, and safety...
January 4, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/29299360/prognostic-relevance-of-human-papillomavirus-infection-in-anal-squamous-cell-carcinoma-analysis-of-the-national-cancer-data-base
#16
Jaymin Jhaveri, Lael Rayfield, Yuan Liu, Mudit Chowdhary, Richard J Cassidy, Nicholas A Madden, Daniel G Tanenbaum, Theresa W Gillespie, Pretesh R Patel, Kirtesh R Patel, Jerome C Landry
Background: To examine the prognostic relevance of human papillomavirus (HPV) infection for anal squamous cell carcinoma (ASCC) patients treated with chemoradiation (CRT) in the National Cancer Data Base (NCDB). Methods: The 2014 NCDB was queried for non-metastatic, histologically confirmed, ASCC patients diagnosed between 2004 and 2013. Patients were required to have HPV status documented in order to be eligible. Patients were then stratified into two groups: HPV+ and HPV-...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29297754/impact-of-patient-reminders-on-papanicolaou-test-completion-for-high-risk-patients-identified-by-a-clinical-decision-support-system
#17
Kathy L MacLaughlin, Maya E Kessler, Ravikumar Komandur Elayavilli, Branden C Hickey, Marianne R Scheitel, Kavishwar B Wagholikar, Hongfang Liu, Walter K Kremers, Rajeev Chaudhry
BACKGROUND: A clinical decision support system (CDSS) for cervical cancer screening identifies patients due for routine cervical cancer screening. Yet, high-risk patients who require more frequent screening or earlier follow-up to address past abnormal results are not identified. We aimed to assess the effect of a complex CDSS, incorporating national guidelines for high-risk patient screening and abnormal result management, its implementation to identify patients overdue for testing, and the outcome of sending a targeted recommendation for follow-up...
January 3, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29297294/combining-agent-based-models-and-virtual-screening-techniques-to-predict-the-best-citrus-derived-vaccine-adjuvants-against-human-papilloma-virus
#18
Marzio Pennisi, Giulia Russo, Silvia Ravalli, Francesco Pappalardo
BACKGROUND: Human papillomavirus infection is a global social burden that, every year, leads to thousands new diagnosis of cancer. The introduction of a protocol of immunization, with Gardasil and Cervarix vaccines, has radically changed the way this infection easily spreads among people. Even though vaccination is only preventive and not therapeutic, it is a strong tool capable to avoid the consequences that this pathogen could cause. Gardasil vaccine is not free from side effects and the duration of immunity is not always well determined...
December 28, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29296202/cell-death-and-restoration-of-trail-sensitivity-by-ciglitazone-in-resistant-cervical-cancer-cells
#19
Marie-Laure Plissonnier, Sylvie Fauconnet, Hugues Bittard, Christiane Mougin, Jean Rommelaere, Isabelle Lascombe
Known activators of the Peroxisome Proliferator-Activated Receptor γ (PPARγ), thiazolidinediones (TZD) induce apoptosis in a variety of cancer cells through dependent and/or independent mechanisms of the receptor. We tested a panel of TZD (Rosiglitazone, Pioglitazone, Ciglitazone) to shed light on their potential therapeutic effects on three cervical cancer cell lines (HeLa, Ca Ski, C-33 A). In these cells, only ciglitazone triggered apoptosis through PPARγ-independent mechanisms and in particular via both extrinsic and intrinsic pathways in Ca Ski cells containing Human PapillomaVirus (HPV) type 16...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29289814/safety-and-acceptability-of-human-papillomavirus-testing-of-self-collected-specimens-a-methodologic-study-of-the-impact-of-collection-devices-and-hpv-assays-on-sensitivity-for-cervical-cancer-and-high-grade-lesions
#20
Maarit K Leinonen, Kristina Schee, Christine M Jonassen, A Kathrine Lie, Camilla F Nystrand, Anbjørg Rangberg, Ingegerd E Furre, Marzena J Johansson, Ameli Tropé, Katrine D Sjøborg, Philip E Castle, Mari Nygård
BACKGROUND: Comparative data on different self-collection methods is limited. OBJECTIVES: To assess the impact of hrHPV testing of two self-collection devices for detection of cervical carcinoma and high-grade lesions. STUDY DESIGN: Three hundred ten patients collected two cervicovaginal specimens using a brush (Evalyn®Brush) and a swab (FLOQSwabs™), and filled a questionnaire at home. Then, a physician at the clinic took a cervical specimen into PreservCyt® buffer for hrHPV testing and cytology...
December 21, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
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