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Human papillomavirus testing

Suhong Xiao, Ying-Sheng Tang, Praveen Kusumanchi, Sally P Stabler, Ying Zhang, Asok C Antony
Background: Epidemiologic and in vitro studies suggest independent linkages between poor folate and/or vitamin B-12 nutrition, genomic human papillomavirus (HPV) type 16 viral integration, and cancer. However, there is no direct evidence in vivo to support the causative role of poor folate nutrition in HPV16 integration into the cellular genome. Objective: We tested the hypothesis that folate deficiency enables the integration of HPV16 into the genome of HPV16-harboring keratinocytes, and could thereby influence earlier transformation of these cells to cancer in an animal model...
March 1, 2018: Journal of Nutrition
Sothy Touch, Jin-Kyoung Oh
BACKGROUND: There is little information concerning the preventive behaviors against cervical cancer among women in Cambodia, a country without organized cervical cancer screening programs and national human papillomavirus (HPV) vaccination policies. We aimed to examine the cervical cancer knowledge, attitudes, and practices as well as cervical cancer prevention methods among Cambodian women. METHODS: A community-based cross-sectional survey on cervical cancer prevention was conducted...
March 15, 2018: BMC Cancer
Yimin Ge, Paul Christensen, Eric Luna, Donna Armylagos, Jiaqiong Xu, Mary R Schwartz, Dina R Mody
OBJECTIVE: Human papillomavirus (HPV) tests and genotyping (GT) have been used in clinical risk assessment. The purpose of this study was to analyze the performance of 2 common HPV testing platforms in risk evaluation for high-grade cervical lesions. MATERIALS AND METHODS: Between January 1, 2015, and December 31, 2016, a total of 4,562 Pap tests with follow-up biopsies in our laboratory database were analyzed along with HPV tests performed on Cobas (CHPV, n = 3,959) or Aptima (AHPV, n = 603) platforms...
March 14, 2018: Journal of Lower Genital Tract Disease
Liv Reidun Tverelv, Sveinung Wergeland Sørbye, Finn Egil Skjeldestad
OBJECTIVE: The Norwegian Cervical Cancer Screening Programme recommends follow-up of histologically confirmed normal/cervical intraepithelial neoplasia (CIN) 1 with combined cytology and human papillomavirus testing within 6 to 12 months. This study examines adherence to guidelines and subsequent risk for CIN 3+ within this subset of women. MATERIALS AND METHODS: Women aged 25 to 69 years attending the Norwegian Cervical Cancer Screening Programme in Norway's 2 northernmost counties were included...
March 14, 2018: Journal of Lower Genital Tract Disease
Mery Natali Silva Abreu, Angela Deise Soares, Diemack Alle Oliveira Ramos, Fernanda Vieira Soares, Gerson Nunes Filho, Analina Furtado Valadão, Patrícia Gonçalves da Motta
Several studies have identified misconceptions about human papillomavirus (HPV), which can lead to negligent behavior and risk to the health of the population. This article aims to assess the knowledge of men and women about HPV in the city of Ipatinga, Minas Gerais, and evaluate socioeconomic factors and preventive measures associated with such knowledge. It involved a cross-sectional study with 591 subjects living in the city, by means of stratified sampling by quotas proportional to the number of individuals by sex and age in each of the eight administrative regions of the city...
March 2018: Ciência & Saúde Coletiva
Sari L Reisner, Madeline B Deutsch, Sarah M Peitzmeier, Jaclyn M White Hughto, Timothy P Cavanaugh, Dana J Pardee, Sarah A McLean, Lori A Panther, Marcy Gelman, Matthew J Mimiaga, Jennifer E Potter
BACKGROUND: High-risk human papillomavirus (hrHPV) causes virtually all cervical cancers. Trans masculine (TM) people (those assigned female at birth who identify with a gender other than female) have low uptake of conventional cervical cancer screening. Self-collected hrHPV DNA testing has high levels of acceptability among cisgender (non-transgender) females and may support increased cervical cancer screening uptake in TM individuals. OBJECTIVE: To assess the test performance and acceptability of self-collected vaginal specimens in comparison to provider-collected cervical swabs for hrHPV DNA detection in TM individuals ages 21-64 years...
2018: PloS One
Jane M Garbutt, Sherry Dodd, Emily Walling, Amanda A Lee, Katharine Kulka, Rebecca Lobb
BACKGROUND: The national guideline for use of the vaccine targeting oncogenic strains of the human papillomavirus (HPV) is an evidence-based practice that is poorly implemented in primary care. Recommendations include completion of the vaccine series before the 13th birthday for girls and boys, giving the first dose at the 11- to 12-year-old check-up visit, concurrent with other recommended vaccines. Interventions to increase implementation of this guideline have had little impact, and opportunities to prevent cancer continue to be missed...
March 13, 2018: Implementation Science: IS
Hanna Artemchuk, Tina Triglav, Anja Oštrbenk, Mario Poljak, Joakim Dillner, Helena Faust
Background: The antibody response against HPV-16 and -18 is well known, but many genital HPV types are oncogenic. We assessed the correlation between HPV DNA and antibodies to eleven HPV types. Methods: 2,024 women attending the organized national cervical cancer screening program in Slovenia were tested for cervical high-risk HPV DNA (HPV-16,-18,-31,-33,-35,-39,-45,-52,-56,-58,-59,-68) and serum anti-HPV antibodies. 1,848 of these women were tested with the same methods three years earlier...
February 26, 2018: Journal of Infectious Diseases
Sarah Cotton, Robert E Brown, Elizabeth K Nugent, Sonia C Robazetti, Pamela D Berens, Judith A Smith
OBJECTIVE: To assess the consistency between human papillomavirus (HPV) mRNA testing in women with a history of previous HPV infections diagnosed by HPV DNA assay and the potential effects on follow-up HPV screening. METHODS: This was a quality improvement study that used data from a pathology laboratory software database reviewed from November 2014 to June 2016 to identify female patients aged 30 years or older with greater than one HPV-positive result, including one or more HPV mRNA assay results and one or more documented HPV DNA assay results for comparison...
March 8, 2018: Obstetrics and Gynecology
Ravit Bassal, Yoav Guilburd, Hagit Shapira, Joseph Azuri, Judith Zandbank, Eduardo Schejter
BACKGROUND: The human papillomavirus (HPV) test has proven to be efficient in triaging women with abnormal Pap findings in women with low cytological atypia, but there is no data about the accuracy for large loop excision of transformation zone in cases of recurrent atypia. OBJECTIVES: To assess the clinical correlation between results of HPV typing and conization histology in women who had recurrent abnormal Pap test results with no colposcopy findings. METHODS: Our retrospective cohort study included 138 women enrolled in the Maccabi Healthcare Services who had consecutive atypical Pap test results for 2 years in which no abnormal colposcopic findings were detected...
March 2018: Israel Medical Association Journal: IMAJ
Yasmine Ghantous, Sharon Akrish, Yoav Leiser, Imad Abu El-Naaj
BACKGROUND: Several types of human papillomavirus (HPV) have been found to be associated with oral squamous cell carcinoma (OSCC). Still, the significance of HPV infection and its relationship to patient prognosis remains an important matter of debate. OBJECTIVES: To investigate the incidence of HPV infection in OSCC patients in northern Israel populations to determine its role in the etiology and prognosis of OSCC. METHODS: OSCC tissues were gathered from the pathology departments at Rambam and Padeh medical centers in northern Israel...
March 2018: Israel Medical Association Journal: IMAJ
Meg Watson, Vicki Benard, Elaine W Flagg
Improved understanding of the natural history of cervical cancer has led to changes in screening recommendations, including the addition of the human papillomavirus (HPV) testing as an option in routine screening. Most studies of screening trends have used national self-reported survey data. To better understand recent trends in cervical cancer screening, including cytology (Papanicolaou, or Pap, tests) and human papillomavirus co-tests (HPV + Pap test), we used healthcare claims data to examine screening practices and trends...
March 2018: Preventive Medicine Reports
Lulu Yu, Mingyue Jiang, Pengpeng Qu, Zeni Wu, Peisong Sun, Mingrong Xi, Yu Qin, Xin Liu, Guangdong Liao, Xiaoqin Lei, Lixin Sun, Yongzhen Zhang, Zhifang Li, Wen Chen, You-Lin Qiao
HPV-16 and -18 account for about 80% of cervical cancers. We evaluated the performance of HPV-16/18 oncoprotein to predict precancer and cancer in corresponding tissue biopsy specimens. 1008 women attending cervical cancer screening program and 638 women referred to colposcopy with biopsy-confirmed cervical intraepithelial neoplasia grade 2 or worse (CIN2+) from 4 hospitals were recruited (1646 in total). All women were tested OncoE6 (AVC), Liquid Based Cytology (Hologic) and cobas HPV test (Roche). Colposcopy was performed on women with any abnormal results...
March 9, 2018: International Journal of Cancer. Journal International du Cancer
Xiumin Zhao, Qiongyan Wu, Xinyu Wang, Yunfeng Fu, Xiaofei Zhang, Xun Tian, Bei Cheng, Bingjian Lu, Xiao Yu, Suqiu Lan, Weiguo Lu, Ding Ma, Xiaodong Cheng, Xing Xie
OBJECTIVES: We aimed to assess the performance of DH3 human papillomavirus (HPV) assay, a newly developed hybrid capture technique that detects 14 high-risk HPVs with type 16/18 genotyping, as a primary test in cervical cancer screening. METHODS: Totally 11,356 Chinese women aged 21-65 years participated in a cervical cancer screening program using cytology (Thinprep, Hologic) and HPV testing (Cobas 4800 Test, Roche). Residual samples were used to detect HPV by DH3 HPV...
March 5, 2018: Clinical Microbiology and Infection
Fatma Beyazit, Fatma Sılan, Meryem Gencer, Buket Aydin, Barış Paksoy, Mesut A Unsal, Ozturk Ozdemir
OBJECTIVES: Cervical cancer is the second most common type of cancer for women worldwide with a great proportion proved to be related to human papillomavirus (HPV) infection. As infection with HPV is the strongest risk factor for cervical neoplasia, detection of HPV genotypes in cervical and vaginal specimens of women with normal and abnormal cytology seems to be of paramount importance in cervical cancer screening. The objective of the study is to evaluate the prevalence and HPV genotypes among women with normal or abnormal Pap smear tests...
2018: Ginekologia Polska
M Saville, D Hawkes, E Mclachlan, S Anderson, K Arabena
Background: Commencing 1 December 2017, Australia introduced human papillomavirus (hpv)-based cervical screening. As part of this Australian renewed National Cervical Screening Program (ncsp) women who are either never- or under-screened and who refuse a practitioner collected sample will be able to collect their own sample for cervical screening. The aim of this study is to examine the quantitative results of a pilot study into the acceptability of the self-collection alternative pathway...
February 2018: Current Oncology
E McLachlan, S Anderson, D Hawkes, M Saville, K Arabena
Objectives: To examine factors that enhance under-screened and never-screened women's completion of the self-collection alternative pathway of the Renewed National Cervical Screening Program (ncsp) in Victoria, Australia. Background: With the Australian ncsp changing, starting on 1 December 2017, the Medical Services Advisory Committee (msac) recommended implementing human papillomavirus (hpv) testing using a self-collected sample for under-screened and never-screened populations...
February 2018: Current Oncology
Mengfei Xu, Feng Zhou, Lili Huang
RATIONALE: Concomitant malignancy of the endometrium and cervix is extremely rare. PATIENT CONCERNS: A 56-year-old female presented to the Women's Hospital, School of Medicine, Zhejiang University, complaining of irregular vaginal bleeding. The human papillomavirus test (type 18/45) was positive. We performed dilation and curettage; pathology revealed moderately differentiated endometrial carcinoma exhibiting squamous differentiation. The epithelium of the cervical uterus was atypical upon biopsy...
January 2018: Medicine (Baltimore)
Cynthia M Rand, Hollyce Tyrrell, Rachel Wallace-Brodeur, Nicolas P N Goldstein, Paul M Darden, Sharon G Humiston, Christina S Albertin, William Stratbucker, Stanley J Schaffer, Wendy Davis, Peter G Szilagyi
OBJECTIVE: Human papillomavirus (HPV) vaccination rates remain low, in part because of missed opportunities (MOs) for vaccination. We used a learning collaborative quality improvement (QI) model to assess the effect of a multicomponent intervention on reducing MOs. METHODS: Study design: pre-post using a QI intervention in 33 community practices and 14 pediatric continuity clinics over 9 months to reduce MOs for HPV vaccination at all visit types. MEASURES: outcome measures comprised baseline and postproject measures of 1) MOs (primary outcome), and 2) HPV vaccine initiation and completion...
March 2018: Academic Pediatrics
Fırat Dogan, Selvi Deniz Dorttas, Seval Bilge Dagalp, Veysel Soydal Ataseven, Feray Alkan
Papillomaviruses (PVs) are epitheliotropic viruses that cause benign proliferative lesions in the skin (warts or papillomas) and mucous membranes of their natural hosts. Recently, new PVs have been found in many animal species. The most common current approach for identifying novel PV types is based on PCR, using various consensus or degenerated primer (broad-range primers), designed on the basis of the multiple alignment of nucleotide or amino acid sequences of a large number of different human papillomaviruses (HPV)...
March 3, 2018: Archives of Virology
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