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Human papillomavirus testing

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https://www.readbyqxmd.com/read/27912928/translating-self-persuasion-into-an-adolescent-hpv-vaccine-promotion-intervention-for-parents-attending-safety-net-clinics
#1
Austin S Baldwin, Deanna C Denman, Margarita Sala, Emily G Marks, L Aubree Shay, Sobha Fuller, Donna Persaud, Simon Craddock Lee, Celette Sugg Skinner, Deborah J Wiebe, Jasmin A Tiro
OBJECTIVE: Self-persuasion is an effective behavior change strategy, but has not been translated for low-income, less educated, uninsured populations attending safety-net clinics or to promote human papillomavirus (HPV) vaccination. We developed a tablet-based application (in English and Spanish) to elicit parental self-persuasion for adolescent HPV vaccination and evaluated its feasibility in a safety-net population. METHODS: Parents (N=45) of age-eligible adolescents used the self-persuasion application...
November 20, 2016: Patient Education and Counseling
https://www.readbyqxmd.com/read/27905473/carcinogenic-human-papillomavirus-infection
#2
Mark Schiffman, John Doorbar, Nicolas Wentzensen, Silvia de Sanjosé, Carole Fakhry, Bradley J Monk, Margaret A Stanley, Silvia Franceschi
Infections with human papillomavirus (HPV) are common and transmitted by direct contact. Although the great majority of infections resolve within 2 years, 13 phylogenetically related, sexually transmitted HPV genotypes, notably HPV16, cause - if not controlled immunologically or by screening - virtually all cervical cancers worldwide, a large fraction of other anogenital cancers and an increasing proportion of oropharyngeal cancers. The carcinogenicity of these HPV types results primarily from the activity of the oncoproteins E6 and E7, which impair growth regulatory pathways...
December 1, 2016: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/27902759/seroprevalence-and-associated-factors-of-9-valent-human-papillomavirus-hpv-types-among-men-in-the-multinational-him-study
#3
Shams Rahman, Christine M Pierce Campbell, Dana E Rollison, Wei Wang, Tim Waterboer, Angelika Michel, Michael Pawlita, Luisa L Villa, Eduardo Lazcano Ponce, Amy R Borenstein, Anna R Giuliano
BACKGROUND: Human papillomavirus (HPV) is one of the most common sexually transmitted infections worldwide. Recently a 9-valent HPV (9vHPV) prophylactic vaccine was licensed. Seroprevalence prior to vaccine dissemination is needed for monitoring vaccine effectiveness over time. Few studies have assessed the seroprevalence of 9vHPV types in men. OBJECTIVES: To investigate the seroprevalence of 9vHPV vaccine types and associated risk factors among men residing in Brazil, Mexico, and the United States...
2016: PloS One
https://www.readbyqxmd.com/read/27902363/seroprevalence-of-cutaneous-human-papillomaviruses-hpv-among-men-in-the-multinational-him-study
#4
Shams Rahman, Christine M Pierce Campbell, Tim Waterboer, Dana E Rollison, Donna J Ingles, B Nelson Torres, Angelika Michel, Staci L Sudenga, Michael Pawlita, Luisa L Villa, Eduardo Lazcano Ponce, Amy R Borenstein, Wei Wang, Anna R Giuliano
Data on cutaneous HPV seroprevalence is primarily derived from skin cancer case-controls studies. Few studies have reported the seroprevalence of cutaneous HPV among healthy men. This study investigated the seroprevalence of cutaneous HPV types and associated risk factors among men residing in Brazil, Mexico, and the United States. Six hundred men were randomly selected from the HPV Infection in Men (HIM) Study. Archived serum specimens were tested for antibodies against 14 cutaneous HPV genotypes, β-HPV types (5/8/12/14/17/22/23/24/38/48), α-HPV 27, γ-HPV 4, µ-HPV1 and ν-HPV 41 using a GST L1-based multiplex serology assay...
October 6, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27900000/involvement-of-tp53-and-tp16-expression-in-human-papillomavirus-associated-non-small-cell-lung-cancer
#5
Ming Li, Xiao-Lei Zhang, Fang Deng, Li-Ting Qian, Shui-Ping Meng, Wu-Lin Shan, Bao-Long Wang
Human papilloma virus (HPV) infection has previously been reported to be associated with TP53 and TP16 expression in Japanese and Taiwanese patients with lung cancer, but data for advanced non-small cell lung cancer (NSCLC) patients is limited. The present study examined the association between HPV infection and TP53 and TP16 expression in Chinese patients with advanced NSCLC. HPV DNA was detected in 20 out of 83 (24%) lung tumors, and was observed more frequently in non-smokers, patients with lymph node metastasis, and patients with poorly differentiated tumors (P=0...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27898576/sexually-transmitted-disease-testing-and-uptake-of-human-papillomavirus-vaccine-in-a-large-online-survey-of-us-men-who-have-sex-with-men-at-risk-for-hiv-infection-2012
#6
Erin M Kahle, Elissa Meites, R Craig Sineath, Muazzam Nasrullah, Kristina E Bowles, Elizabeth DiNenno, Patrick S Sullivan, Travis Sanchez
National guidelines recommend annual human immunodeficiency virus (HIV)/sexually transmitted disease testing for sexually active men who have sex with men (MSM) and vaccination against human papillomavirus for MSM through age 26. A 2012 online survey of 2,794 MSM found that 51%, 36%, and 14% reported receiving human immunodeficiency virus testing, sexually transmitted disease testing, and human papillomavirus vaccination, respectively.
November 28, 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27896666/characteristics-associated-with-hpv-diagnosis-and-perceived-risk-for-cervical-cancer-among-unmarried-sexually-active-college-women
#7
Kelly L Wilson, Clayton J Cowart, Brittany L Rosen, Jairus C Pulczinski, Kayce D Solari, Marcia G Ory, Matthew Lee Smith
Human papillomavirus (HPV) has been identified as the leading cause of cervical cancer. While HPV risk factors have been well studied, less is known about those with HPV and their perceptions about health ramifications. The purposes of this study were to examine unmarried college student women's (1) HPV diagnosis status and (2) perceived risk of getting cervical cancer in the next 5 years. Data were analyzed from 1106 unmarried, sexually active college women aged 18 to 26. Binary logistic regression compared HPV-related knowledge, vaccination-related perceptions, mandate support, healthcare utilization, sexual behaviors, and personal characteristics...
November 28, 2016: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/27896251/combined-sybr-green-real-time-polymerase-chain-reaction-and-microarray-method-for-the-simultaneous-determination-of-human-papillomavirus-loads-and-genotypes
#8
Hyun Hee Seo, Young Jun Kim, Mi Seon Jeong, Sung Ran Hong, In Ho Lee, Kyeong A So, Mi-Kyung Kim, Yoo Kyung Lee, Ki Heon Lee, Juree Kim, Sung Jae Kim, Tae Jin Kim
OBJECTIVE: The aim of this study was to describe the principle of the Cheil HPV DNA Chip assay and evaluate its accuracy. In order to quantify the human papillomavirus (HPV) load and identify HPV genotypes simultaneously, this assay combined the two methods: SYBR Green quantitative real-time polymerase chain reaction (PCR) and DNA microarray. METHODS: We designed novel consensus primer sets that target the conserved region of the HPV L1 gene for quantifying and detecting a broad range of HPV types by quantitative real-time PCR...
November 2016: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/27894986/application-of-molecular-genotyping-to-determine-prevalence-of-hpv-strains-in-pap-smears-of-kazakhstan-women
#9
Luiza Niyazmetova, Gulzhanat Aimagambetova, Nazigul Stambekova, Zaurech Abugalieva, Korlukain Seksembayeva, Syed Ali, Azliyati Azizan
OBJECTIVES: Human papillomavirus is the main causative agents for cervical cancer. However, few data are available about HPV prevalence in Kazakhstan. The aims of this study were to genotype HPV DNA in Pap smear samples of women to determine prevalence of carcinogenic HPV types in Astana, Kazakhstan and to analyze the association between HPV positivity and the cytology results of patient samples. METHODS: Pap smear materials were obtained from 140 patients aged 18-59, who visited the outpatient gynecological clinic...
November 25, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27894910/cervical-cancer-screening-in-women-vaccinated-against-human-papillomavirus-infection-recommendations-from-a-consensus-conference
#10
Paolo Giorgi Rossi, Francesca Carozzi, Antonio Federici, Guglielmo Ronco, Marco Zappa, Silvia Franceschi
In Italy, the cohorts of women who were offered Human papillomavirus (HPV) vaccination in 2007/08 will reach the age for cervical cancer (CC) screening from 2017. The simultaneous shift from cytology-based screening to HPV test-based screening gives the opportunity for unprecedented reorganisation of CC prevention. The ONS (National Screening Monitoring Centre) Directive and the GISCi (Italian Group for Cervical Screening) identified the consensus conference as the most suitable method for addressing this topic...
November 25, 2016: Preventive Medicine
https://www.readbyqxmd.com/read/27893841/seroprevalence-of-cutaneous-human-papillomaviruses-and-the-risk-of-external-genital-lesions-in-men-a-nested-case-control-study
#11
Shams Rahman, Dana E Rollison, Christine M Pierce Campbell, Tim Waterboer, Angelika Michel, Michael Pawlita, Luisa L Villa, Eduardo Lazcano Ponce, Wei Wang, Amy R Borenstein, Anna R Giuliano
BACKGROUND: A variety of cutaneous human papillomaviruses (HPV) are detectable in genital epithelial lesions in men and non-melanoma skin cancer patients. It remains unclear whether these viruses are associated causally with skin lesions. To date, no study has prospectively examined the association between cutaneous HPV seropositivity and development of external genital lesions (EGLs) in men. OBJECTIVES: To examine the association between seropositivity to cutaneous HPV types and the risk of subsequent development of EGLs...
2016: PloS One
https://www.readbyqxmd.com/read/27893418/high-risk-hpv-genotypes-and-p16ink4a-expression-in-a-cohort-of-head-and-neck-squamous-cell-carcinoma-patients-in-singapore
#12
Louise Soo Yee Tan, Petersson Fredrik, Liang Ker, Feng Gang Yu, De Yun Wang, Boon Cher Goh, Kwok Seng Loh, Chwee Ming Lim
Human papillomavirus (HPV), especially HPV16 genotype, is associated with oropharyngeal squamous cell carcinoma (OPSCC). We aim to determine the prevalence and characterize the high-risk (HR)-HPV genotypes in head and neck SCC (HNSCC) in a South-East Asian multi-ethnic society in Singapore and examine its prognostic significance.159 HNSCC archival tissue samples were retrieved and tumour DNA was screened for 18 HR-HPV genotypes using a PCR-based assay (Qiagen, digene HPV genotyping RH test). P16 protein overexpression was identified using immunohistochemistry (IHC)...
November 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27893206/no-significant-association-between-human-papillomavirus-and-breast-cancer-sanandaj-iran
#13
Maryam Karimi, Mazaher Khodabandehloo, Bahram Nikkhoo, Ebrahim Ghaderi
Background and Objective: Any role of human papillomavirus (HPV) in the development of breast cancer is conjectural. The aim of this study was to investigate possible links between HPV and breast cancer in women, Sanandaj, Iran. Methods: In this case-control study, 70 formalin fixed and paraffin embedded blocks of breast malignant tumors as a case group and 70 blocks of lesions without malignancy were selected as controls. Sections about 10 μm thick were prepared. After removing the paraffin, DNA was extracted...
January 10, 2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27891686/implementation-of-a-real-time-reference-and-calibration-grid-platform-for-improved-screening-mapping-in-pap-test-slides
#14
Evangelos Tsiambas, Christos Riziotis
Cervical cancer screening based on the Papanicolaou (Pap) test is a widely applied but not always efficient practice for detecting Human Papillomavirus (HPV) mediated lesions, partially due to a non-systematic and inadequate screening process. Our aim was to introduce an inexpensive easy-to-use direct screening platform for improved detection of abnormal cells indicative of underlying cervical neoplasia as well as persisting HPV infection. By employing a novel, efficient technique of laser-based micromachining, we achieved the fabrication of spatial grids on commercially available coverslips allowing visual segmentation of the slide for efficient screening...
November 27, 2016: Pathology International
https://www.readbyqxmd.com/read/27891616/human-papillomavirus-induced-oropharyngeal-cancer-in-hispanics-in-the-united-states
#15
Giovana R Thomas, Kaming Lo, Raphael Nwojo
OBJECTIVES/HYPOTHESIS: Determine disparities in survival outcome and clinical presentation between Hispanic and non-Hispanic white patients with human papillomavirus-positive oropharyngeal squamous cell carcinoma. STUDY DESIGN: Retrospective clinical research. METHODS: Clinical data on Hispanics and non-Hispanic white patients with diagnosis of human papillomavirus/p16-positive oropharyngeal squamous cell carcinoma were drawn from a tumor registry from the University of Miami Hospitals and Clinics from 2008 to 2014...
November 28, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27889034/human-immunodeficiency-virus-aids-human-papillomavirus-and-anal-cancer
#16
REVIEW
Chia-Ching J Wang, Joseph Sparano, Joel M Palefsky
Anal cancer is an increasingly common non-AIDS-defining cancer among individuals infected with the human immunodeficiency virus (HIV). It is associated with human papillomavirus (HPV). HPV16 is the most common genotype detected in anal cancers. The HPV types detected in anal cancer are included in the 9-valent vaccine. HPV vaccines have demonstrated efficacy in reducing anal precancerous lesions in HIV-infected individuals. Standard treatment has been fluorouracil and mitomycin (or cisplatin) plus radiation...
January 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/27888116/hpv16-induces-a-wasting-syndrome-in-transgenic-mice-amelioration-by-dietary-polyphenols-via-nf-%C3%AE%C2%BAb-inhibition
#17
Rui M Gil da Costa, Sofia Aragão, Magda Moutinho, Antonieta Alvarado, Diogo Carmo, Fátima Casaca, Sandra Silva, Joana Ribeiro, Hugo Sousa, Rita Ferreira, Rita Nogueira-Ferreira, Maria João Pires, Bruno Colaço, Carlos Venâncio, Maria Manuel Oliveira, Margarida M S M Bastos, Carlos Lopes, Paula A Oliveira
Cancer patients often show a wasting syndrome for which there are little therapeutic options. Dietary polyphenols have been proposed for treating this syndrome, but their usefulness in cases associated with human papillomavirus (HPV)-induced cancers is unknown. We characterized HPV16-transgenic mice as a model of cancer cachexia and tested the efficacy of long-term oral supplementation with polyphenols curcumin and rutin. Both compounds were orally administered to six weeks-old HPV16-transgenic mice showing characteristic multi-step skin carcinogenesis, for 24weeks...
November 22, 2016: Life Sciences
https://www.readbyqxmd.com/read/27887795/clinician-knowledge-clinician-barriers-and-perceived-parental-barriers-regarding-human-papillomavirus-vaccination-association-with-initiation-and-completion-rates
#18
Lila J Finney Rutten, Jennifer L St Sauver, Timothy J Beebe, Patrick M Wilson, Debra J Jacobson, Chun Fan, Carmen Radecki Breitkopf, Susan T Vadaparampil, Robert M Jacobson
PURPOSE: We tested the hypothesis that clinician knowledge, clinician barriers, and perceived parental barriers relevant to the human papillomavirus (HPV) vaccination account for the variation in vaccine delivery at the practice-site level. METHODS: We conducted a survey from October 2015 through January 2016 among primary care clinicians (n=280) in a 27-county geographic region to assess clinician knowledge, clinician barriers, and perceived parental barriers regarding HPV vaccination...
November 23, 2016: Vaccine
https://www.readbyqxmd.com/read/27882657/using-a-semi-conductor-sequencing-based-panel-for-genotyping-of-hpv-positive-and-hpv-negative-oropharyngeal-cancer-a-retrospective-pilot-study
#19
Janneke C Ham, Bastiaan B J Tops, Chantal M L Driessen, Annemiek W M van Raaij, Piet J Slootweg, Willem J G Melchers, Marjolijn J L Ligtenberg, Carla M L van Herpen
OBJECTIVES: The aim of this study was to assess the feasibility of testing actionable mutations in small amounts of formalin fixed paraffin embed material in multiple genes of the receptor tyrosine kinase pathway and to determine the frequency of these mutations in human papillomavirus (HPV)-positive and HPV-negative oropharyngeal cancer (OPC). DESIGN: A retrospective pilot study was performed. SETTING: In OPC no predictive markers for response to epidermal growth factor receptor (EGFR) inhibition are known...
November 24, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27881082/quality-assurance-of-human-papillomavirus-hpv-testing-in-the-implementation-of-hpv-primary-screening-in-norway-an-inter-laboratory-reproducibility-study
#20
Birgit Engesæter, Bianca van Diermen Hidle, Mona Hansen, Pia Moltu, Kjersti Mangseth Staby, Siri Borchgrevink-Persen, Olav K Vintermyr, Stefan Lönnberg, Mari Nygård, Emiel A M Janssen, Philip E Castle, Irene Kraus Christiansen
BACKGROUND: Human papillomavirus (HPV) testing as primary screening for cervical cancer is currently being implemented in Norway in a randomized controlled fashion, involving three laboratories. As part of the quality assurance programme of the implementation, an evaluation of the inter-laboratory reproducibility of the HPV test was initiated, to ensure satisfactory HPV test reliability in all three laboratories. METHODS: The HPV test used is the cobas 4800 HPV Test, detecting 14 high-risk types with individual HPV genotype results for HPV16 and HPV18...
November 24, 2016: BMC Infectious Diseases
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