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Allergic Rhinits

D Häussler, J U Sommer, A Nastev, C Aderhold, A Wenzel, B Kramer, B A Stuck, R Birk
PURPOSE: MP 29-02, which contains fluticasone propionate and azelastine hydrochloride, is used as a topical nasal application for the treatment of seasonal and perennial allergic rhinitis. Although a multitude of data is available on the clinical symptom reduction and treatment safety of MP 29-02, the effect of MP 29-02 on ciliary beat frequency (CBF) has not been evaluated thus far. METHODS: MP 29-02-containing solution was applied at concentrations of 2.5, 5, 10, and 20% to 14 healthy subjects, and nasal ciliated epithelial cells were then visualized using a phase-contrast microscope...
June 2018: European Archives of Oto-rhino-laryngology
Almira Ćosićkić, Fahrija Skokić, Amela Selimović, Maida Mulić, Sanimir Suljendić, Nermina Dedić, Damir Sabitović, Fejzo Džafić
Children with atopic dermatitis (AD) usually develop symptoms when they reach the age of 6-7 years, but the risk of developing respiratory allergies, asthma and allergic rhinitis (AR) remains high. In most children with AD, the development of asthma and AR is associated with sensitization to food allergens and/or aeroallergens, while only a small percentage missed atopic diathesis. In about 35% of children with AD, food allergy is the provoking cause, and 60% of infants who had AD in the first 3 months of life were sensitized against aeroallergens by the age of 5...
June 2017: Acta Clinica Croatica
Mattias P Tschannen, Ulrich Glück, Andreas J Bircher, Ingmar Heijnen, Claudia Pletscher
Thaumatin is a sweetener and flavor modifier commonly used in the food industry. Likewise, gum arabic is widely used as a food stabilizer and thickening agent. We report here that a powder mixture composed of 10% thaumatin and 90% gum arabic led to allergic symptoms in the upper airways in occupationally exposed individuals: four of eight workers of a chewing gum factory exposed to this powder mixture had pronounced rhinitis. A positive skin prick test result for pure thaumatin was obtained in all four individuals with rhinitis of whom two also had a positive skin prick test result for pure gum arabic and gum arabic-specific IgE...
July 2017: American Journal of Industrial Medicine
A B Ozturk, R Bayraktar, B Gogebakan, S Mumbuc, H Bayram
BACKGROUND: Although studies have reported an association between air pollutants and increased allergic airway diseases, such as allergic rhinitis and nasal polyposis, the underlying mechanisms are not fully understood. A limited number of studies have suggested that diesel exhaust particles (DEP) play a role in atopy and the pathogenesis of allergic upper airway diseases. The aim of this study was to investigate the effect of DEP on inflammatory cytokine release, and mRNA expression of transcription factors such as JNK and NF-β in primary nasal epithelial cells (NECs), in vitro...
March 2, 2017: Allergologia et Immunopathologia
Erica A Pawlak, Terry L Noah, Haibo Zhou, Claire Chehrazi, Carole Robinette, David Diaz-Sanchez, Loretta Müller, Ilona Jaspers
Exposure to diesel exhaust (DE) is known to exacerbate allergic inflammation, including virus-induced eosinophil activation in laboratory animals. We have previously shown that in human volunteers with allergic rhinitis a short-term exposure to DE prior to infection with the live attenuated influenza virus (LAIV) increases markers of allergic inflammation in the nasal mucosa. Specifically, levels of eosinophilic cationic protein (ECP) were significantly enhanced in individuals exposed to DE prior to inoculation with LAIV and this effect was maintained for at least seven days...
May 6, 2016: Particle and Fibre Toxicology
Omer T Selcuk, Ali Eraslan, Serkan Filiz, Levent Renda, Nursel T Selcuk, Hulya Eyigor, Ustun Osma, Mustafa D Yilmaz
BACKGROUND: Allergic rhinitis (AR) is a disease that reduces athletic performance. Environmental allergen exposure is higher in outdoor sports (such as orienteering) than indoor sports. The main purpose of this study was to investigate the AR frequency in orienteers comparing with indoor athletes. METHODS: Sixty adolescent athletes (33 orienteers, 27 basketball players) enrolled this prospective study. AR diagnosis was made by both history (ISAAC questionnaire) and physical examination...
July 2017: Journal of Sports Medicine and Physical Fitness
Di Zhao, Ruixia Ma, Xueliang Shen, Huiyu Ha
OBJECTIVE: To investigate the epidemic features of childhood allergic rhinitis (AR) and correlative risk factors in Yinchuan. METHOD: A questionnaire survey on AR was conducted among 800 children in eight communities, aged from 5 to 14 years old, by random cluster sampling, from March 2012 to March 2013 in Yinchuan. Suspects of AR, as identified by the survey, were recommended to specialist examinations for accurate diagnosis. The results were statistically analyzed...
August 2015: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
L Colavita, M Miraglia Del Giudice, G Stroscio, C Visalli, T Alterio, C Pidone, M R Pizzino, T Arrigo, R Chimenz, C Salpietro, C Cuppari
Allergic rhinitis (AR) and adenoid hypertrophy (AH) are common in children and are often associated with each other. Recent studies have shown improvement of respiratory symptoms and reduction in the adenoid volume after anti-allergic medical therapy (intranasal corticosteroids, antihistamines). The aim of our retrospective study is to evaluate the effectiveness of adenoidectomy on respiratory symptoms in pediatric patients with AR. We recruited 404 pediatric patients with AR, and we divided them into 4 groups (1...
April 2015: Journal of Biological Regulators and Homeostatic Agents
Aarif O Eifan, Nara T Orban, Mikila R Jacobson, Stephen R Durham
RATIONALE: Increases in airway smooth muscle, extracellular matrix, and vascularity are prominent features of airway remodeling in asthma, whereas the extent of such remodeling in patients with persistent allergic rhinitis (PAR) is unknown. OBJECTIVES: To test the hypothesis that upper airway remodeling is a feature of PAR. METHODS: Total nasal symptoms scores, nasal biopsies, and Th1 and Th2 cytokines from nasal lavage were assessed in subjects with severe PAR (n = 46) and healthy control subjects (n = 19)...
December 15, 2015: American Journal of Respiratory and Critical Care Medicine
H Eke Gungor, U M Sahiner, Y Altuner Torun
AIM: Forced expiratory flow between 25%and75% of vital capacity (FEF25-75%), a spirometric measure of small airways, may predict the presence of airway responsiveness both in asthmatics and in allergic rhinitics. We aimed to search the correlation between FEF25-75% and standard measures of spirometry (FEV1% and FEV1/FVC) in different clinical conditions, that is in children with asthma, in children with asthma and allergic rhinitis, in children with allergic rhinitis and in healthy children METHODS: Children with asthma(n=116), asthma plus allergic rhinitis(n=25), allergic rhinitis(n=75) and healthy controls(n=52) were evaluated...
September 11, 2015: Minerva Pediatrica
Annelie F Behndig, Karthika Shanmuganathan, Laura Whitmarsh, Nikolai Stenfors, Joanna L Brown, Anthony J Frew, Frank J Kelly, Ian S Mudway, Thomas Sandström, Susan J Wilson
BACKGROUND: Epidemiological evidence demonstrates that exposure to traffic-derived pollution worsens respiratory symptoms in asthmatics, but controlled human exposure studies have failed to provide a mechanism for this effect. Here we investigated whether diesel exhaust (DE) would induce apoptosis or proliferation in the bronchial epithelium in vivo and thus contribute to respiratory symptoms. METHODS: Moderate (n = 16) and mild (n = 16) asthmatics, atopic non-asthmatic controls (rhinitics) (n = 13) and healthy controls (n = 21) were exposed to filtered air or DE (100 μg/m(3)) for 2 h, on two separate occasions...
August 25, 2015: BMC Pulmonary Medicine
Janet Rimmer, Conceição Santos, Eija Yli-Panula, Virginia Noronha, Markku Viander
BACKGROUND: The precise way in which allergen is handled by the nose is unknown. The objective of this study was to determine recovery of Der p 1 allergen following nasal administration and to determine whether Der p 1 can be detected in nasal biopsies after natural exposure and nasal challenge to allergen. METHODS: (1) 20 nonatopic non-rhinitics were challenged with Der p 1 and recovery was measured by ELISA in the nasal wash, nasal mucus and induced sputum up to 30 minutes...
2015: PloS One
Philippe Jean Bousquet, Philippe Devillier, Abir Tadmouri, Kamal Mesbah, Pascal Demoly, Jean Bousquet
BACKGROUND: Disease stratification, using phenotypic characterization performed either by hypothesis- or data-driven methods, was developed to improve clinical decisions. However, cluster analysis has not been used for allergic rhinitis. OBJECTIVE: To define clusters in allergic rhinitis and to compare them with ARIA (Allergic Rhinitis and Its Impact on Asthma), a hypothesis-driven approach. METHODS: A French observational prospective multicenter study (EVEIL: Echelle visuelle analogique dans la rhinite allergique) was carried out on 990 patients consulting general practitioners for allergic rhinitis and treated as per clinical practice...
2015: International Archives of Allergy and Immunology
Eugenio De Corso, Silvia Baroni, Mariapina Battista, Matteo Romanello, Romina Penitente, Walter Di Nardo, Giulio Cesare Passali, Bruno Sergi, Anna Rita Fetoni, Francesco Bussu, Cecilia Zuppi, Gaetano Paludetti
BACKGROUND: The aim of the present study was to measure eotaxin-3 (CCL26) and eotaxin-2 (CCL24) in nasal lavage fluid of patients with different forms of chronic sinonasal eosinophilic inflammation to evaluate their role in the pathophysiology of nasal hypereosinophilia. METHODS: The study was an analytic cross-section study, level of evidence 3b. Patients (n = 80) with nasal hypereosinophilia were randomly recruited and grouped in the following categories: persistent allergic rhinitis (AR) (n = 25), nonallergic rhinitis with eosinophilia syndrome (NARES) (n = 30), and chronic rhinosinusitis with polyps (CRSwNP) (n = 25)...
August 2014: International Forum of Allergy & Rhinology
Duygu Göksay Kadaifciler, Suzan Ökten, Burhan Sen
Studies on dental units (DUs) are conducted either for the prevention or the reduction of the density of bacterial contamination in dental unit waterlines (DUWLs). However, the existence of fungi in the these systems requires more attention. During dental treatment, direct contact with water contaminated with fungi such as Candida, Aspergillus, or inhalation of aerosols from high-speed drill may cause various respiratory infections, such as asthma, allergies, and wounds on mucose membranes, especially on immunocompromised patients and dentists...
2013: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
Vanya M Tsvetkova-Vicheva, Svetla P Gecheva, Regina Komsa-Penkova, Angelika S Velkova, Tcvetan H Lukanov
BACKGROUND: Th2-type T cell response has a considerable role in atopic diseases. The involvement of Th17 and IL-17 in atopy process provided new understanding of allergic diseases. Bronchial hyperresponsiveness is quite common in allergic rhinitis. We aimed to explore the expression of IL-17 producing CD3+ CD4+ T cells in peripheral blood of rhinitic patients, with/without bronchial hyperresponsiveness and sensitized to common allergens, as this relationship has not been examined. METHODS: Sixty one patients with allergic rhinitis and thirty controls were examined...
January 15, 2014: Clinical and Translational Allergy
M Denguezli Bouzgarou, M Ben Ali, A Ben Salem, S Gaied, C Aouichaoui, J-F Dessanges, Z Tabka
INTRODUCTION: The high prevalence of allergic rhinitis that occurs in elite athletes has been extensively investigated. However, data among recreational athletes practicing indoor activities remain contradictory. The aim of the present study was to determine whether taking part in gym based sporting activities constitutes a risk factor for allergic rhinitis in recreational athletes. METHODS: A group of 50 recreational athletes was examined. A specific questionnaire for the screening of allergic rhinitis and a battery of skin prick-tests to aeroallergens were administered to each participant...
September 2013: Revue des Maladies Respiratoires
D Dokic, E Trajkovska-Dokic
A double-blind randomised trail design was used to address the effect of ambient ozone on the nasal airways and to evaluate the effects of ozone on allergic mucosa. Ten grass pollen allergic rhinitics were exposed for 2 hours at rest on 2 separate occasions to 400 ppb ozone and filtered air respectively. The exposure to 400 ppb ozone and filtered air was performed prior to the grass pollen season and again during the season. Baseline nasal lavage in which histamine, eosinophil cationic protein (ECP), myeloperoxidase (MPO), total proteins, and albumin were measured and neutrophils, eosinophils and epithelial cells were counted, was made immediately prior to exposure (-120 min)...
2013: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
Robin John Green, Maurice Hockman, Raymond Friedman, Martin Davis, Marinda McDonald, Riaz Seedat, Carla Els, Michael Levin, Paul C Potter, Charles Feldman
The term rhinitis implies inflammation of the lining of the nose. Characteristic symptoms are a blocked nose, anterior and posterior rhinorrhea, sneezing and itching. Not all cases of chronic rhinitis have an allergic basis. Chronic non-allergic rhinitis is defined as a condition where ongoing rhinitic symptoms are present for many months (as for persistent allergic rhinitis) but there is no IgE basis. Many common conditions may present as chronic rhinitis, which will need to be investigated and managed on their own merits...
June 2013: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
Nirina Larsson, Joanna Brown, Nikolai Stenfors, Susan Wilson, Ian S Mudway, Jamshid Pourazar, Annelie F Behndig
CONTEXT: Proximity to traffic, particularly to diesel-powered vehicles, has been associated with inducing and enhancing allergies. To investigate the basis for this association, we performed controlled exposures of allergic rhinitics to diesel exhaust (DE) at a dose known to be pro-inflammatory in healthy individuals. OBJECTIVE: We hypothesized that diesel-exhaust exposure would augment lower airway inflammation in allergic rhinitics. MATERIALS AND METHODS: Fourteen allergic rhinitics were exposed in a double-blinded, randomized trial to DE (100 μg/m³ PM₁₀) and filtered air for 2 h on separate occasions...
February 2013: Inhalation Toxicology
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