Yanqing Xie, Xiaotian Ju, Suzanne Beaudin, Lesley Wiltshire, John Paul, Jonathan MacLean Oliveria, Doron D Sommer, Ruth Cusack, Olga Li, Prajna Banerjee, Paul K Keith, Paul M O'Byrne, Rebecca N Bauer, Tracy Staton, Gail M Gauvreau, Roma Sehmi
BACKGROUND: Allergic rhinitis is characterized by rhinorrhea, nasal congestion, sneezing and nasal pruritis. Group 2 innate lymphoid cells (ILC2s), CD4+ T cells and eosinophils in nasal mucosa are increased significantly after nasal allergen challenge (NAC). Effects of intranasal corticosteroids (INCS) on ILC2s remains to be investigated. METHODS: Subjects (n=10) with allergic rhinitis and mild asthma were enrolled in a single-blind, placebo-controlled, sequential treatment study and treated twice daily with intranasaltriamcinolone acetonide(220µg) or placebo for 14 days,separated by a 7-day washout period...
March 30, 2021: Allergy