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https://www.readbyqxmd.com/read/28812235/patent-ethics-the-misalignment-of-views-between-the-patent-system-and-the-wider-society
#1
Ellen-Marie Forsberg, Anders Braarud Hanssen, Hanne Marie Nielsen, Ingrid Olesen
Concerns have been voiced about the ethical implications of patenting practices in the field of biotechnology. Some of these have also been incorporated into regulation, such as the European Commission Directive 98/44 on the legal protection of biotechnological inventions. However, the incorporation of ethically based restrictions into patent legislation has not had the effect of satisfying all concerns. In this article, we will systematically compare the richness of ethical concerns surrounding biotech patenting, with the limited scope of ethical concerns actually addressed in the patent system...
August 15, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28806273/the-changing-landscape-of-gene-editing-in-hematopoietic-stem-cells-a-step-towards-cas9-clinical-translation
#2
Daniel P Dever, Matthew H Porteus
PURPOSE OF REVIEW: Since the discovery two decades ago that programmable endonucleases can be engineered to modify human cells at single nucleotide resolution, the concept of genome editing was born. Now these technologies are being applied to therapeutically relevant cell types, including hematopoietic stem cells (HSC), which possess the power to repopulate an entire blood and immune system. The purpose of this review is to discuss the changing landscape of genome editing in hematopoietic stem cells (GE-HSC) from the discovery stage to the preclinical stage, with the imminent goal of clinical translation for the treatment of serious genetic diseases of the blood and immune system...
August 12, 2017: Current Opinion in Hematology
https://www.readbyqxmd.com/read/28800417/buccal-delivery-of-small-molecules-and-biologics-of-mucoadhesive-polymers-films-and-nanoparticles
#3
REVIEW
Javier O Morales, David J Brayden
Buccal delivery of macromolecules (biologics) sets a great challenge for researchers. Although several niche small molecule products have been approved as simple sprays, tablets and oral films, it is not simply a case of adapting existing technologies to biologics. Buccal delivery of insulin has reached clinical trials with two approaches: oromucosal sprays of the peptide with permeation enhancers, and embedded gold nanoparticles in a dissolvable film. However, neither of these approaches have led to FDA approvals likely due to poor efficacy, submaximal peptide loading in the dosage form, and to wide intra-subject variability in pharmacokinetics and pharmacodynamics...
August 8, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/28753441/rnai-mediated-resistance-to-viruses-a-critical-assessment-of-methodologies
#4
REVIEW
Mikhail M Pooggin
In plants, RNA interference (RNAi)-based antiviral defense is mediated by multigenic families of Dicer-like enzymes generating small interfering (si)RNAs from double-stranded RNA (dsRNA) produced during replication and/or transcription of RNA and DNA viruses, and Argonaute enzymes binding viral siRNAs and targeting viral RNA and DNA for siRNA-directed posttranscriptional and transcriptional silencing. Successful viruses are able to suppress or evade the production or action of viral siRNAs. In antiviral biotech approaches based on RNAi, transgenic expression or non-transgenic delivery of dsRNA cognate to a target virus pre-activates or boosts the natural plant antiviral defenses...
July 25, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28753060/workshop-on-recent-issues-in-bioanalysis-wrib-poster-award-winners-2017
#5
Neil Simmons, John Lowe, Annelies Coddens
The 11th WRIB held in Los Angeles, CA, USA in April 2017. It drew over 750 professionals representing large Pharmas, Biotechs, CROs and multiple regulatory agencies from around the world, from the global bioanalytical community. Bioanalysis and Bioanalysis Zone are very proud to be supporting the WRIB Poster Awards again this year, and we feature the profiles of the authors of the winning posters. Visit www.bioanalysis-zone.com to see the winning posters in full.
July 2017: Bioanalysis
https://www.readbyqxmd.com/read/28750594/global-capacity-potentials-and-trends-of-solid-waste-research-and-management
#6
Michael A Nwachukwu, Mersky Ronald, Huan Feng
In this study, United States, China, India, United Kingdom, Nigeria, Egypt, Brazil, Italy, Germany, Taiwan, Australia, Canada and Mexico were selected to represent the global community. This enabled an overview of solid waste management worldwide and between developed and developing countries. These are countries that feature most in the International Conference on Solid Waste Technology and Management (ICSW) over the past 20 years. A total of 1452 articles directly on solid waste management and technology were reviewed and credited to their original country of research...
July 1, 2017: Waste Management & Research
https://www.readbyqxmd.com/read/28747227/high-rhesus-rh-d-negative-frequency-and-ethnic-group-based-abo-blood-group-distribution-in-ethiopia
#7
Lemu Golassa, Arega Tsegaye, Berhanu Erko, Hassen Mamo
BACKGROUND: Knowledge of the distribution of ABO-Rh(D) blood groups in a locality is vital for safe blood services. However, the distribution of these blood systems among Ethiopians in general is little explored. This study was, therefore, designed to determine the ABO-Rh(D) blood group distribution among patients attending Gambella hospital, southwestern Ethiopia. METHODS: A cross-sectional study was conducted between November and December 2013 (N = 449). The patients were grouped into two broad categories...
July 26, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28713787/consumers-preferences-for-a-local-food-product-the-case-of-a-new-carnaroli-rice-product-in-lombardy
#8
Giovanni Ferrazzi, Vera Ventura, Sabrina Ratti, Claudia Balzaretti
Italy, with a cultivated area of 218,000 ha, is a European leader of rice production. In particular Lombardy region accounts for 40% of total rice cultivation and the case study in object accounts for 3.2% of Lombardy total rice area (2773 ha). Starting from 2012, through a regional project titled Buono, Sano e Vicino (good, healthy and close), Riso e Rane rural district supported local rice farmers in developing innovation in rice production and promoting an alternative supply chain to increase farmers bargaining power and promote new market strategies...
April 13, 2017: Italian Journal of Food Safety
https://www.readbyqxmd.com/read/28705454/efficacy-of-two-different-doses-of-rabbit-anti-t-lymphocyte-globulin-to-prevent-graft-versus-host-disease-in-children-with-haematological-malignancies-transplanted-from-an-unrelated-donor-a-multicentre-randomised-open-label-phase-3-trial
#9
Franco Locatelli, Maria Ester Bernardo, Alice Bertaina, Carla Rognoni, Patrizia Comoli, Attilio Rovelli, Andrea Pession, Franca Fagioli, Claudio Favre, Edoardo Lanino, Giovanna Giorgiani, Pietro Merli, Daria Pagliara, Arcangelo Prete, Marco Zecca
BACKGROUND: Although rabbit anti-T-lymphocyte globulin (ATLG) is largely used for the prevention of immune-mediated complications in patients given allogeneic haemopoietic stem-cell transplantation (HSCT) from an unrelated donor, the optimum dose of this drug in children is still undefined. We aimed to test whether a higher dose of ATLG was superior to a lower dose for prevention of grade II-IV acute graft-versus-host disease (GVHD). METHODS: We conducted a multicentre, randomised, open-label, phase 3 trial in seven Italian centres comparing two different doses of ATLG (30 mg/kg vs 15 mg/kg, given intravenously over 3 days, from day -4 to -2) in children (aged 0-18 years) with haematological malignancies transplanted from an unrelated donor, selected using high-resolution typing for HLA-class I/II loci...
August 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28700547/public-biotech-in-2016-the-numbers
#10
Chris Morrison, Riku Lähteenmäki
No abstract text is available yet for this article.
July 12, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28700546/wanted-biotech-for-an-aging-population
#11
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
July 12, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28699320/a-three-plus-three-parameters-mechanistic-model-for-viral-filtration
#12
Prakhar Misra, Abhishek Sinha, Fasil Q Mir, Anurag S Rathore, Anupam Shukla
Viral filtration is an expensive regulatory requirement in downstream processing of monoclonal antibodies (mAbs). This process step is typically operated with an overdesigned filter in order to account for any batch to batch variability in the filter, as well as the feed characteristics. Here, we propose a simple, six-parameter mechanistic model for viral filtration where three parameters are membrane-specific while the other three depend on feed characteristics and membrane-feed interactions. Viruses are considered as passive particles which are retained by the membrane on the basis of size exclusion...
July 11, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28696178/a-cheat-sheet-to-navigate-the-complex-maze-of-pharmaceutical-exclusivities-in-europe
#13
Marta Cavero Tomas, Bo Peng
As the two leading markets for pharmaceutical and biotech companies, the USA and Europe offer incentives to stimulate drug innovation, including patent and regulatory exclusivities. These exclusivities extend periods during which companies can market their products free of generic or other competition and recoup their investment. Pharmaceutical and biotech companies should carefully assess the different types of exclusivities available when developing regulatory submissions, patent filing strategies. The authors have previously summarized the USA exclusivities in an earlier publication...
July 11, 2017: Pharmaceutical Patent Analyst
https://www.readbyqxmd.com/read/28695633/industry-responsibilities-in-tackling-direct-to-consumer-marketing-of-unproven-stem-cell-treatments
#14
REVIEW
Z Master, W Fu, D Paciulli, D Sipp
The direct-to-consumer marketing of unproven stem cell interventions (SCIs) is a serious public health concern. Regulations and education have had modest impact, indicating that different actors must play a role to stop this unfettered market. We consider the role of the biotech industry in tackling unproven SCIs. Grounded in the concept of corporate social responsibility, we argue that biotech companies should screen consumers to ensure that products and services are being used appropriately and educate employees about unproven SCIs...
August 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28693752/glyphosate-and-ampa-pseudo-persistent-pollutants-under-real-world-agricultural-management-practices-in-the-mesopotamic-pampas-agroecosystem-argentina
#15
Jezabel E Primost, Damián J G Marino, Virginia C Aparicio, José Luis Costa, Pedro Carriquiriborde
In the Pampas, public concern has strongly risen because of the intensive use of glyphosate for weed control and fallow associated with biotech crops. The present study was aimed to evaluate the occurrence and concentration of the herbicide and its main metabolite (AMPA) in soil and other environmental compartments of the mentioned agroecosystem, including groundwater, in relation to real-world agricultural management practices in the region. Occurrence was almost ubiquitous in solid matrices (83-100%) with maximum concentrations among the higher reported in the world (soil: 8105 and 38939; sediment: 3294 and 7219; suspended particulate matter (SPM): 584 and 475 μg/kg of glyphosate and AMPA)...
July 7, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28692267/is-multitask-deep-learning-practical-for-pharma
#16
Bharath Ramsundar, Bowen Liu, Zhenqin Wu, Andreas Verras, Matthew Tudor, Robert P Sheridan, Vijay S Pande
Multitask deep learning has emerged as a powerful tool for computational drug discovery. However, despite a number of preliminary studies, multitask deep networks have yet to be widely deployed in the pharmaceutical and biotech industries. This lack of acceptance stems from both software difficulties and from lack of understanding of the robustness of multitask deep networks. Our work aims to resolve both of these barriers to adoption. We introduce a high-quality open-source implementation of multitask deep networks as part of the DeepChem open-source platform...
July 10, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28682860/a-biomechanical-analysis-of-plate-fixation-using-unicortical-and-bicortical-screws-in-transverse-metacarpal-fracture-models-subjected-to-4-point-bending-and-dynamical-bending-test
#17
Eirini Liodaki, Robert Wendlandt, Klaus Waizner, Brigitte E Schopp, Peter Mailänder, Felix Stang
In the published literature there are controversial data to the biomechanical stability of monocortical comparing to the bicortical fixation of metacarpal fractures. The aim of this study was to compare the biomechanical stability of monocortical and bicortical locking osteosynthesis in quasi-static and dynamic 4-point bending tests of composite third metacarpal bone (4th Gen third metacarpal, Sawbones, Malmö, Sweden) fixed with 7-hole locking plate (XXS System, Biotech-Ortho, Wright, Memphis, TN). The tests to determine quasi-static yield and bending strength as well as fatigue strength were conducted in 4 groups of 10 samples after creating standardized mid-shaft transverse osteotomies using a diamont belt grinder (0...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28679327/micro-factors-bringing-the-pharmaceutical-industry-to-a-seismic-shaking-a-qualitative-research
#18
REVIEW
Raphaela Marie Louisa Dierks, Olivier Bruyère, Jean-Yves Reginster
INTRODUCTION: Due to changing macro and micro factors, expiring patents and falling net income, pharmaceutical companies need to rethink their vertical business model. The trend shows cross-sectorial partnerships and consolidation to remain and compete on the market. Areas covered: Quantitative research interviewing a target group of 25 key executives from small, mid and large global pharmaceutical companies rounded with qualitative literature research completing the analysis. Expert commentary: Uncertainty in the industry due to changing external factors i...
June 2017: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/28675243/biotech-innovations-in-the-prevention-of-respiratory-infectious-diseases
#19
Julia Valeria Cento, Silvia Barbaliscia, Carlo Federico Perno
review is the creation of a biocompatible, biogel-based nasal filter enriched with AgNPs. Compared to traditional personal protective equipment (PPE), this type of nasal filter has the advantage of combining the antibacterial and antiviral activity of AgNPs with the common filtration capacity shared by other PPEs. This dual mechanism means that AgNP-enriched nasal filters serve to reduce the infecting microbial-load and protect the lower airways, without interfering with the normal respiratory capacity (airflow-resistance <5%)...
July 4, 2017: New Microbiologica
https://www.readbyqxmd.com/read/28670498/application-of-afp-whole-blood-one-step-rapid-detection-kit-in-screening-for-hcc-in-qidong
#20
Jie Jin, Xiao-Yan Zhang, Jin-Lei Shi, Xue-Feng Xue, Ling-Ling Lu, Jian-Hua Lu, Xiao-Ping Jiang, Jiang-Feng Hu, Ben-Song Duan, Chang-Qing Yang, Da-Ru Lu, De-Li Lu, Jian-Guo Chen, Heng-Jun Gao
Hepatocellular carcinoma (HCC) is a big problem in China where the Hepatitis B (HBV) infection patients are near to 120 million. Early screening and diagnosis is the key to reduce the incidence and mortality of HCC. Serum AFP detection is the main methods for diagnosis, recurrent monitoring and therapeutic evaluation of primary HCC. Hepatitis patients should detect the AFP at least once every six months to help early diagnosis of HCC. Unfortunately, most hepatitis and other liver disease patients do not test their AFP regularly...
2017: American Journal of Cancer Research
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