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https://www.readbyqxmd.com/read/27914981/complement-a-primer-for-the-coming-therapeutic-revolution
#1
REVIEW
Scott R Barnum
The complement system is an important part of the innate and adaptive immune systems. Originally characterized as a single serum component contributing to the killing of bacteria, we now know that there are close to sixty complement proteins, multiple activation pathways and a wide range of effector functions mediated by complement. The system plays a critical role in host defense against bacteria, viruses, fungi and other pathogens. However, inappropriate complement activation contributes to the pathophysiology of autoimmune diseases and many inflammatory syndromes...
November 30, 2016: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27914286/multi-centre-field-evaluation-of-the-performance-of-the-trinity-biotech-uni-gold-hiv-1-2-rapid-test-as-a-first-line-screening-assay-for-gay-and-bisexual-men-compared-with-4th-generation-laboratory-immunoassays
#2
P Keen, D P Conway, P Cunningham, A McNulty, D L Couldwell, S C Davies, D E Smith, J Gray, M Holt, C C O'Connor, P Read, D Callander, G Prestage, R Guy
BACKGROUND: The Trinity Biotech Uni-Gold HIV test (Uni-Gold) is often used as a supplementary rapid test in testing algorithms. OBJECTIVE: To evaluate the operational performance of the Uni-Gold as a first-line screening test among gay and bisexual men (GBM) in a setting where 4th generation HIV laboratory assays are routinely used. STUDY DESIGN: We compared the performance of Uni-Gold with conventional HIV serology conducted in parallel among GBM attending 22 testing sites...
November 16, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27899625/ym500v3-a-database-for-small-rna-sequencing-in-human-cancer-research
#3
I-Fang Chung, Shing-Jyh Chang, Chen-Yang Chen, Shu-Hsuan Liu, Chia-Yang Li, Chia-Hao Chan, Chuan-Chi Shih, Wei-Chung Cheng
We previously presented the YM500 database, which contains >8000 small RNA sequencing (smRNA-seq) data sets and integrated analysis results for various cancer miRNome studies. In the updated YM500v3 database (http://ngs.ym.edu.tw/ym500/) presented herein, we not only focus on miRNAs but also on other functional small non-coding RNAs (sncRNAs), such as PIWI-interacting RNAs (piRNAs), tRNA-derived fragments (tRFs), small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs). There is growing knowledge of the role of sncRNAs in gene regulation and tumorigenesis...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27891561/citrus-psorosis-virus-coat-protein-derived-hairpin-construct-confers-stable-transgenic-resistance-in-citrus-against-psorosis-a-and-b-syndromes
#4
A De Francesco, N Costa, M L García
Citrus psorosis virus (CPsV) is the causal agent of psorosis, a serious and widespread citrus disease. Two syndromes of psorosis, PsA and PsB, have been described. PsB is the most aggressive and rampant form. Previously, we obtained Pineapple sweet orange plants transformed with a hairpin construct derived from the CPsV coat protein gene (ihpCP). Some of these plants were resistant to CPsV 90-1-1, a PsA isolate homologous to the transgene. In this study, we found that expression of the ihpCP transgene and siRNA production in lines ihpCP-10 and -15 were stable with time and propagation...
November 28, 2016: Transgenic Research
https://www.readbyqxmd.com/read/27889071/using-x-ray-crystallography-to-simplify-and-accelerate-biologics-drug-development
#5
REVIEW
Mark L Brader, Edward N Baker, Michael F Dunn, Thomas M Laue, John F Carpenter
Every major biopharmaceutical company incorporates a protein crystallography unit that is central to its structure-based drug discovery efforts. Yet these capabilities are rarely leveraged toward the formal higher order structural characterization that is so challenging but integral to large-scale biologics manufacturing. Although the biotech industry laments the shortcomings of its favored biophysical techniques, x-ray crystallography is not even considered for drug development. Why not? We suggest that this is due, at least in part, to outdated thinking (for a recent industry-wide survey, see Gabrielson JP, Weiss IV WF...
November 23, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27864713/a-prospective-randomized-study-for-efficacy-of-an-uncovered-double-bare-metal-stent-compared-to-a-single-bare-metal-stent-in-malignant-biliary-obstruction
#6
Hyun Jik Lee, Moon Jae Chung, Jeong Yup Park, Seung Woo Park, Chung Mo Nam, Si Young Song, Seungmin Bang
BACKGROUND AND AIMS: A biliary self-expandable metal stent (SEMS) is commonly used to relieve malignant biliary obstruction. The aim of this study was to compare the efficacy of a conventional uncovered SEMS with that of a newly developed uncovered double bare metal stent in reducing the risk of stent occlusion caused by tumor ingrowth. PATIENTS AND METHODS: We performed a prospective, open-labeled, randomized trial in 71 patients at Severance Hospital, Yonsei University College of Medicine from June 2013 to June 2014...
November 18, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27844458/intergeneric-fusant-development-using-chitinase-preparation-of-rhizopus-stolonifer-ncim-880
#7
Kailas D Sonawane, Narayan R Dandagal, Akibjaved G Naikwadi, Piyush T Gurav, Samar V Anapat, Naiem H Nadaf, Deepak B Jadhav, Shailesh R Waghmare
Fungal chitinase have tremendous applications in biotech industries, with this approach we focused on extracellular chitinase from Rhizopus stolonifer NCIM 880 for the formation of fungal protoplasts. The maximum chitinase production reached after 24 h at 2.5% colloidal chitin concentration in presence of starch as an inducer. Chitinase was extracted efficiently at 65% cold acetone concentration and then purified by using DEAE-Cellulose column chromatography. Purified chitinase having molecular weight 22 kDa with single polypeptide chain was optimally active at pH 5...
December 2016: AMB Express
https://www.readbyqxmd.com/read/27835762/il-15-signaling-in-nk-cell-cancer-immunotherapy
#8
REVIEW
Jai Rautela, Nicholas D Huntington
While cancer has been traditionally treated by chemotherapy, radiation, targeted therapies and surgery, a fifth pillar of cancer treatment, immunotherapy, has emerged over the past 10 years and revolutionized our war on cancer. The benchmark for drugs in this category has been set by the development of CD8 T cell checkpoint (CTLA-4 and PD-1/PD-L1) inhibitors. These therapies effectively expand and reactivate the pool of tumor-specific T cells leading to objective response rates of up to 50% in patients with certain cancers...
November 8, 2016: Current Opinion in Immunology
https://www.readbyqxmd.com/read/27824846/third-quarter-biotech-job-picture
#9
Michael Francisco
No abstract text is available yet for this article.
November 8, 2016: Nature Biotechnology
https://www.readbyqxmd.com/read/27824287/interview-with-david-j-brayden
#10
David J Brayden
David Brayden speaks to Hannah Makin, Commissioning Editor: David Brayden is a Full Professor (Advanced Drug Delivery) at the School of Veterinary Medicine, University College Dublin (UCD) and also a Fellow of the UCD Conway Institute. Following a PhD in Pharmacology at the University of Cambridge, UK (1989), and a postdoctoral research fellowship at Stanford University, CA, USA, he set up Elan Biotechnology Research's in vitro pharmacology laboratory in Dublin (1991). At Elan, he became a senior scientist and project manager of several of Elan's joint-venture drug delivery research collaborations with US biotech companies...
November 8, 2016: Therapeutic Delivery
https://www.readbyqxmd.com/read/27822948/delayed-high-output-heart-failure-due-to-arteriovenous-fistula-complicated-with-herniated-disc-surgery
#11
Taeshik Park, Sang Ho Park, Alok Arora
A 36-year-old male presented with progressive exertional dyspnea over months. Physical examination showed jugular venous distension, lung crecipitations, femoral bruit and pitting pedal edema. Echocardiogram showed a dilated right ventricle with severe pulmonary hypertension and a non collapsing inferior vena cava (IVC). On right heart catheterization, IVC oxygen saturation was noted at 92% suggesting arterial mixing; a computed tomography of the abdomen showed a fistula between the right common iliac artery to the right common iliac vein at L4 level and a massive IVC; this was linked to trauma from a disectomy done 16 years ago at L4-L5 level...
December 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27812304/a-comparative-evaluation-of-the-analytical-performances-of-capillarys-2-flex-piercing-tosoh-hlc-723-g8-premier-hb9210-and-roche-cobas-c501-tina-quant-gen-2-analyzers-for-hba1c-determination
#12
Xiaobin Wu, Yan Chao, Zemin Wan, Yunxiu Wang, Yan Ma, Peifeng Ke, Xinzhong Wu, Jianhua Xu, Junhua Zhuang, Xianzhang Huang
INTRODUCTION: Haemoglobin A1c (HbA1c) is widely used in the management of diabetes. Therefore, the reliability and comparability among different analytical methods for its detection have become very important. MATERIALS AND METHODS: A comparative evaluation of the analytical performances (precision, linearity, accuracy, method comparison, and interferences including bilirubin, triglyceride, cholesterol, labile HbA1c (LA1c), vitamin C, aspirin, fetal haemoglobin (HbF), and haemoglobin E (Hb E)) were performed on Capillarys 2 Flex Piercing (Capillarys 2FP) (Sebia, France), Tosoh HLC-723 G8 (Tosoh G8) (Tosoh, Japan), Premier Hb9210 (Trinity Biotech, Ireland) and Roche Cobas c501 (Roche c501) (Roche Diagnostics, Germany)...
October 15, 2016: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/27809756/recent-patents-in-agricultural-biotechnology-focus-on-health
#13
Abdullah Makhzoum, Srividhya Venkataraman, Jocelyne Tremouillaux-Guiller, Kathleen L Hefferon
BACKGROUND: Agricultural biotechnology, including the generation of genetically modified food crops, has been the subject of much controversy over the last few years. Initially serving the basic needs of farmers, Ag Biotech has more recently gained much appeal for its opportunities with respect to both the nutritional and pharmaceutical sciences. METHODS: The following review describes a number of recently approved patents that could have direct implications for the field of medicine...
November 1, 2016: Recent Patents on Food, Nutrition & Agriculture
https://www.readbyqxmd.com/read/27808219/young-scientists-ditch-postdocs-for-biotech-start-ups
#14
Erika Check Hayden
No abstract text is available yet for this article.
November 1, 2016: Nature
https://www.readbyqxmd.com/read/27805479/compulsory-licenses-as-a-defense-in-pharmaceutical-and-biotech-patent-litigation
#15
Andreas von Falck
No abstract text is available yet for this article.
September 2016: Pharmaceutical Patent Analyst
https://www.readbyqxmd.com/read/27789693/3dsnp-a-database-for-linking-human-noncoding-snps-to-their-three-dimensional-interacting-genes
#16
Yiming Lu, Cheng Quan, Hebing Chen, Xiaochen Bo, Chenggang Zhang
The vast noncoding portion of the human genome harbors a rich array of functional elements and disease-causing regulatory variants. Recent high-throughput chromosome conformation capture studies have outlined the principles of these elements interacting and regulating the expression of distal target genes through three-dimensional (3D) chromatin looping. Here we present 3DSNP, an integrated database for annotating human noncoding variants by exploring their roles in the distal interactions between genes and regulatory elements...
October 26, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27783778/-netnography-and-the-bioethical-analysis-of-therapeutic-tourism-blogs-for-stem-cells
#17
Natan Monsores, Cecilia Lopes, Edilnete Maria Bessa Bezerra, Natasha Lunara Silva
Therapeutic tourism is a recent phenomenon in public health and has had repercussions among people with disabilities. Virtual social networks have enabled people to organize themselves to discover ways and means of seeking unconventional treatments in China. In this context, foreign biotech companies have offered experimental cell treatment therapies. In this work, netnography (conducting ethnographic research online) was conducted on the blogs of 58 people who organized campaigns to carry out treatment in China...
October 2016: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/27779936/off-they-go-single-use-technology-in-future-production-biotech-2016-conference-at-zhaw-waedenswil
#18
Elsbeth Heinzelmann
"Keep up with today's single-use technology standard but also remain one step ahead" - that could have been the motto of the BioTech 2016 conference at ZHAW Waedenswil on September 5 and 6, which brought together manufacturers, suppliers, users, regulatory specialists and representatives of organizations in this field to implement single-use devices all over the world. It was an effectiveness analysis of the trend to replace reusable equipment in production facilities with single-use components.
October 2016: Chimia
https://www.readbyqxmd.com/read/27755049/fabrication-of-waterproof-breathable-composite-liquid-dressing-and-its-application-in-diabetic-skin-ulcer-repair
#19
Dong-Lin Xia, Yan-Pei Chen, Yu-Fei Wang, Xiao-Dong Li, Ning Bao, Hong He, Hai-Ying Gu
OBJECTIVES: Diabetic patients are at increased risk of severe skin infections. Covering the wound as early as possible can prevent infection and shorten the course of treatment. In this study, the authors fabricated a waterproof and breathable composite liquid dressing (CLD) that formed a barrier to bacteria and shortened healing time of diabetic rat skin ulcers. METHODS: The CLD was prepared in a formulation that, on evaporation of the liquid carrier, acts as a waterproof, breathable coating on injured skin...
November 2016: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/27730563/fast-protein-liquid-chromatography
#20
Ashkan Madadlou, Siobhan O'Sullivan, David Sheehan
Fast protein liquid chromatography (FPLC) is a form of high-performance chromatography that takes advantage of the high resolution made possible by small-diameter stationary phases. It was originally developed for proteins and features high loading capacity, biocompatible aqueous buffer systems, fast flow rates, and availability of stationary phases in most common chromatography modes (e.g., ion exchange, gel filtration, reversed phase, and affinity). The system makes reproducible separation possible by incorporating a high level of automation including autosamplers, gradient program control, and peak collection...
2017: Methods in Molecular Biology
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