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https://www.readbyqxmd.com/read/29778531/solvent-tolerance-in-bacteria-fulfilling-the-promise-of-the-biotech-era
#1
REVIEW
Hadiastri Kusumawardhani, Rohola Hosseini, Johannes H de Winde
The challenge of sustainably producing highly valuable chemical compounds requires specialized microbial cell factories because many of these compounds can be toxic to microbial hosts. Therefore, solvent-tolerant bacteria are promising production hosts because of their intrinsic tolerance towards these compounds. Recent studies have helped to elucidate the molecular mechanisms involved in solvent tolerance. Advances in synthetic biological tools will enable further development of streamlined solvent-tolerant production hosts and the transfer of solvent-tolerant traits to established industrial strains...
May 16, 2018: Trends in Biotechnology
https://www.readbyqxmd.com/read/29773779/prospects-for-us-cuba-cooperation-in-gastroenterology-hepatology-and-liver-transplantation
#2
Marlen I Castellanos-Fernández, Mirtha Infante-Velázquez, Enrique Arús-Soler, Marcelo Kugelmas, Ramón Bataller, Ramón Villamil-Martínez, Zaily Dorta-Guridi, Caridad Ruenes-Domenech
Gastroenterology, hepatology and liver transplant exchanges between the USA and Cuba have mainly consisted of scientific events and short visits. This has facilitated Cuba's inclusion in recognized scientific organizations, familiarity with Cuba's biotech products for treatment of liver disease, and access by Cuban professionals to the highest level of scientific information for clinical practice. It has also given health professionals in the US a more accurate picture of Cuba's health sector. The results of the Global Alcoholic Liver Disease Survey, which included Cuba and was designed and coordinated in the USA, opened doors to joint research and scientific publications...
April 2018: MEDICC Review
https://www.readbyqxmd.com/read/29760493/blood-sweat-and-tears-in-biotech-the-theranos-story
#3
Eric Topol
No abstract text is available yet for this article.
May 2018: Nature
https://www.readbyqxmd.com/read/29758944/the-conundrum-of-gsk3-inhibitors-is-it-the-dawn-of-a-new-beginning
#4
Ratan V Bhat, Ulf Andersson, Shalini Andersson, Laurent Knerr, Udo Bauer, Anna Sundgren Andersson
Spanning over three decades of extensive drug discovery research, the efforts to develop a potent and selective GSK3 inhibitor as a therapeutic for the treatment of type 2 diabetes, Alzheimer's disease (AD), bipolar disorders and cancer have been futile. Since its initial discovery in 1980 and subsequent decades of research, one cannot underscore the importance of the target and the promise of a game changing disease modifier. Several pharmaceutical companies, biotech companies, and academic institutions raged in a quest to unravel the biology and discover potent and selective GSK3 inhibitors, some of which went through clinical trials...
May 11, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29753801/a-comparative-study-between-2-different-grafts-used-as-patches-after-plaque-incision-and-inflatable-penile-prosthesis-implantation-for-end-stage-peyronie-s-disease
#5
Marco Falcone, Mirko Preto, Carlo Ceruti, Massimiliano Timpano, Giulio Garaffa, Omidreza Sedigh, Mattia Sibona, Marco Oderda, Paolo Gontero, Luigi Rolle
BACKGROUND: Although many grafts have been used for plaque incision with grafting (PIG) and penile prosthesis (PP) implantation, there is no evidence that favors 1 specific graft over another. AIM: To compare fibrin-coated collagen fleece (TachoSil; Baxter International, Deerfield, IL, USA) with porcine small intestinal submucosa (SIS; Cook Biotech, West Lafayette, IN, USA) as grafts. METHODS: From January 2007 to January 2015, 60 non-randomized consecutive patients affected by end-stage Peyronie disease underwent PIG and PP implantation (AMS 700CX; Boston Scientific, Marlborough, MA, USA)...
May 9, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29737436/a-light-controlled-cell-lysis-system-in-bacteria
#6
Geyi Wang, Xin Lu, Yisha Zhu, Wei Zhang, Jiahui Liu, Yankang Wu, Liyang Yu, Dongchang Sun, Feng Cheng
Intracellular products (e.g., insulin), which are obtained through cell lysis, take up a big share of the biotech industry. It is often time-consuming, laborious, and environment-unfriendly to disrupt bacterial cells with traditional methods. In this study, we developed a molecular device for controlling cell lysis with light. We showed that intracellular expression of a single lysin protein was sufficient for efficient bacterial cell lysis. By placing the lysin-encoding gene under the control of an improved light-controlled system, we successfully controlled cell lysis by switching on/off light: OD600 of the Escherichia coli cell culture was decreased by twofold when the light-controlled system was activated under dark condition...
May 8, 2018: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29734312/first-quarter-biotech-job-picture
#7
Michael Francisco
No abstract text is available yet for this article.
May 9, 2018: Nature Biotechnology
https://www.readbyqxmd.com/read/29734304/indian-biotech-sector-readies-for-liftoff
#8
Killugudi Jayaraman
No abstract text is available yet for this article.
May 9, 2018: Nature Biotechnology
https://www.readbyqxmd.com/read/29734300/to-keep-biotechs-trading-at-home-china-pilots-new-stock-market-rules
#9
Shannon Ellis
No abstract text is available yet for this article.
May 9, 2018: Nature Biotechnology
https://www.readbyqxmd.com/read/29734299/unleashing-biotech-s-crouching-tiger
#10
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
May 9, 2018: Nature Biotechnology
https://www.readbyqxmd.com/read/29728611/tmem173-variants-and-potential-importance-to-human-biology-and-disease
#11
REVIEW
Seema Patel, Lei Jin
TMEM173 gene encodes the protein STING (stimulator of interferon genes), a key player in host defense against pathogens. Mutations in the human TMEM173 gene cause a life-threatening auto-inflammatory disease called SAVI (STING-associated vasculopathy with onset in infancy). Human STING is also a promising therapeutic target for cancers and infectious diseases. Recently, Aduro Biotech and Novartis announced a $250M-plus initiative to develop STING-targeting cancer immunotherapies. Thus, understanding the genetics of the human TMEM173 gene is important for both basic and translational research...
May 1, 2018: Genes and Immunity
https://www.readbyqxmd.com/read/29714578/survey-of-safety-information-in-the-investigator-s-brochure-inconsistencies-and-recommendations
#12
Michael Jacob Klepper, Leander Fontaine
A survey was undertaken to gain an understanding of current industry practices in the preparation of the safety information for the Investigator's Brochure (IB). Sixteen of a potential 25 respondents completed a survey (64% response rate). Five respondents represented pharmaceutical and biotech companies, and 11 were consultants or worked at contract research organizations for such companies. The results showed a lack of uniformity of practices. This may be due to the lack of harmonized regulations and guidelines, the lack of standardized terminology and definitions, and the lack of clarity regarding the purpose and content of the various safety-related sections of the IB...
January 1, 2018: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/29714558/assessing-study-start-up-practices-performance-and-perceptions-among-sponsors-and-contract-research-organizations
#13
Mary Jo Lamberti, Michael Wilkinson, Beth Harper, Craig Morgan, Ken Getz
BACKGROUND: Site identification, site selection, and study start-up have become the focus of improvement by organizations conducting clinical trials. METHODS: To examine and measure the process from site identification through site activation, Tufts Center for the Study of Drug Development (CSDD) conducted a comprehensive survey among pharmaceutical organizations, biotech companies, and contract research organizations (CROs). Responses from over 400 unique companies were gathered and analyzed...
January 1, 2018: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/29708836/development-of-new-hepatitis-e-vaccines
#14
Yufeng Cao, Zhenhong Bing, Shiyu Guan, Zecai Zhang, Xinping Wang
Hepatitis E virus (HEV) infection is an emerging zoonotic disease posing a severe threat to public health in the world, especially to pregnant women. Currently, no specific treatments are available for HEV infection. Therefore, it is crucial to develop vaccine to prevent this infection. Although several potential candidate vaccines against HEV have been studied for their immunogenicity and efficacy, only Hecolin® which is developed by Xiamen Innovax Biotech Co., Ltd. and approved by China Food and Drug Administration (CFDA) in 2012, is the licensed HEV vaccine in the world so far...
April 30, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29708077/emerging-drugs-for-the-treatment-of-breast-cancer-brain-metastasis-a-review-of-patent-literature
#15
Maricruz Anaya-Ruiz, Cindy Bandala, Patricia Martinez-Morales, Gerardo Landeta, Rebeca D Martinez-Contreras, Nancy Martinez-Montiel, Martin Perez-Santos
BACKGROUND: Despite dramatic advances in cancer treatment that lead to long-term survival, there is an increasing number of patients presenting with clinical manifestations of cerebral metastasis in breast cancer, for whom only palliative treatment options exist. OBJECTIVE: The present review aims to provide to identify recent patens of breast cancer brain metastasis that may have application in improving cancer treatment. METHOD: Recent patents regarding the breast cancer brain metastasis were obtained from USPTO patent databases, Esp@cenet, Patentscope and Patent Inspiration®...
April 29, 2018: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/29703620/a-comparative-evaluation-of-concentrated-growth-factor-and-platelet-rich-fibrin-on-the-proliferation-migration-and-differentiation-of-human-stem-cells-of-the-apical-papilla
#16
Shebin Hong, Weiting Chen, Beizhan Jiang
INTRODUCTION: Concentrated growth factor (CGF) is considered to be a natural biomaterial that is better than platelet-rich fibrin (PRF) in bone regeneration, but there is little information acquired in regenerative endodontics. Therefore, the purpose of this study was to evaluate their effects on the proliferation, migration, and differentiation of human stem cells of the apical papilla (SCAPs). METHODS: CGF- and PRF-conditioned medium were prepared using the freeze-dried method...
April 24, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29700449/the-first-biotech-dental-product
#17
(no author information available yet)
No abstract text is available yet for this article.
April 27, 2018: British Dental Journal
https://www.readbyqxmd.com/read/29694283/letter-incorporating-real-world-evidence-and-patient-value-criteria-into-value-based-frameworks-for-relapsed-refractory-multiple-myeloma
#18
Robert Z Orlowski
Orlowski has received research funding from Amgen, BioTheryX, Bristol-Myers Squibb, Celgene Corporation, and Takeda Pharmaceuticals; honoraria from Amgen, Bristol-Myers Squibb, Celgene Corporation, Janssen, Millennium Pharmaceuticals, and Onyx Pharmaceuticals; and is a member of advisory boards for Amgen, Bristol-Myers Squibb, Celgene Corporation, Incyte, Kite, Legend Biotech, Sanofi-Aventis, and Takeda Pharmaceuticals.
May 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29656955/from-innovation-to-market-adoption-in-the-operating-room-the-cfo-as-customer
#19
Ryan D Egeland, Zachary Rapp, Frank S David
Dr Egeland is senior director of business development and licensing in the Early Technologies business unit of the Minimally Invasive Therapies Group at Medtronic. Mr Rapp is an associate consultant at Pharmagellan, a biotech consultancy. Dr David is the founder and managing director of Pharmagellan.
September 2017: Surgery
https://www.readbyqxmd.com/read/29627609/distinguishing-allergens-from-non-allergenic-homologues-using-physical-chemical-property-pcp-motifs
#20
Wenzhe Lu, Surendra S Negi, Catherine H Schein, Soheila J Maleki, Barry K Hurlburt, Werner Braun
Quantitative guidelines to distinguish allergenic proteins from related, but non-allergenic ones are urgently needed for regulatory agencies, biotech companies and physicians. In a previous study, we found that allergenic proteins populate a relatively small number of protein families, as characterized by the Pfam database. However, these families also contain non-allergenic proteins, meaning that allergenic determinants must lie within more discrete regions of the sequence. Thus, new methods are needed to discriminate allergenic proteins within those families...
April 5, 2018: Molecular Immunology
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