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https://www.readbyqxmd.com/read/29345681/biotech-booms-in-china
#1
Shannon Ellis
No abstract text is available yet for this article.
January 18, 2018: Nature
https://www.readbyqxmd.com/read/29345658/how-a-biotech-entrepreneur-benefits-from-splitting-time-between-china-and-the-united-states
#2
Sarah O'Meara
No abstract text is available yet for this article.
January 18, 2018: Nature
https://www.readbyqxmd.com/read/29337629/biotech-crop-planting-resumes-high-adoption-in-2016
#3
Rhodora R Aldemita, Randy A Hautea
The global area of biotech crops in 2016 increased from 179.7 million hectares to 185.1 million hectares, a 3% increase equivalent to 5.4 million hectares. Some 26 countries planted biotech crops, 19 of which were developing countries and seven were industrial. Information and data collected from various credible sources showed variations from the previous year. Fluctuations in biotech crop area (both increases and decreases) are influenced by factors including, among others, acceptance and commercialization of new products, demand for meat and livestock feeds, weather conditions, global market price, disease/pest pressure, and government's enabling policies...
January 16, 2018: GM Crops & Food
https://www.readbyqxmd.com/read/29319690/texas-displays-silicon-valley-credentials-to-lure-brazilian-biotechs
#4
Melanie Senior
No abstract text is available yet for this article.
January 10, 2018: Nature Biotechnology
https://www.readbyqxmd.com/read/29319685/china-s-fledgling-biotech-sector-fizzes-into-life
#5
Shannon Ellis
No abstract text is available yet for this article.
January 10, 2018: Nature Biotechnology
https://www.readbyqxmd.com/read/29306677/role-of-raw-materials-in-biopharmaceutical-manufacturing-risk-analysis-and-fingerprinting
#6
REVIEW
Anurag S Rathore, Deepak Kumar, Nikhil Kateja
Accurate fingerprinting of critical raw materials that have significant impact on process performance and product quality is a necessary precursor for implementation of QbD in process and product development. This article presents a review of major developments in this space in the last 10 years, with a special emphasis on those in last 5 years. A step by step approach for managing raw materials in the QbD paradigm has been proposed. We think that it is necessary for the biotech industry to better manage variability originating from raw materials if holistic implementation of QbD is to be achieved...
January 4, 2018: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/29258257/aetmyc1-the-candidate-gene-controlling-the-red-coleoptile-trait-in-aegilops-tauschii-coss-accession-as77
#7
Dong Cao, Guangji Ye, Yuan Zong, Bo Zhang, Wenjie Chen, Baolong Liu, Huaigang Zhang
The red coleoptile trait can help monocotyledonous plants withstand stresses, and key genes responsible for the trait have been isolated from Triticum aestivum, Triticum urartu, and Triticum monococcum, but no corresponding research has been reported for Aegilops tauschii. In this research, transcriptome analysis was performed to isolate the candidate gene controlling the white coleoptile trait in Ae. tauschii. There were 5348 upregulated, differentially-expressed genes (DEGs) and 4761 downregulated DEGs in red coleoptile vs...
December 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29251730/biotech-s-pale-shadow
#8
Brady Huggett
No abstract text is available yet for this article.
December 18, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/29243501/critical-analysis-of-valuation-and-strategical-orientation-of-merger-and-acquisition-deals-in-the-pharmaceutical-industry
#9
Raphaela Marie Louisa Dierks, Olivier Bruyère, Jean-Yves Reginster
the pharmaceutical industry is undergoing major shifts due to changing macro and micro factors. As the industry is highly capital intensive and patents are expiring, the outlook is on generating inorganic growth, mainly through M&A. Using the income valuation approach, one analyses two completed deals in 2016 above 1bn USD. Thereafter one outlines the main motives behind M&A deals and concluded by discussing whether M&A harms medical innovations. Areas covered: the paper is based on empirical study questioning existing literature in order to critically analyse valuation and the strategical orientation of pharmaceutical companies Expert commentary: pharmaceutical companies understand the changing market conditions and favour their expertise...
December 15, 2017: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/29221590/activit%C3%A3-s-immunomodulatrice-anti-inflammatoire-antiprurigineuse-et-tol%C3%A3-rog%C3%A3-nique-induites-par-i-modulia%C3%A2-un-extrait-issu-de-culture-d%C3%A2-aquaphilus-dolomiae-dans-les-mod%C3%A3-les-pharmacologiques-de-dermatite-atopique-immunomodulatory-anti-inflammatory-anti-pruritus
#10
T Nguyen, N Castex-Rizzi, D Redoulès
Atopic dermatitis (AD) is an inflammatory and pruritic dermatosis of multifactorial origin. Topical steroids are the first line treatment for severe AD however alternatives treatment are increasingly needed. A biological concentrate was elaborated from culture of an Avène aquatic microflora isolate namely Aquaphilus dolomiae. Numerous extracts were evaluated in relevant AD in vitro models with human keratinocytes. Among these extracts, a particular one I-modulia® was found to be remarkable in terms of pharmacological activities: innate immunity modulating by agonizing Toll like receptor (TLR)2, TLR4 and TLR5, induction of anti-microbial peptides, inhibition of cytokines characteristics of T helper (Th)1, Th2 and Th17 responses, inhibition of Protease-activated-receptor (PAR) 2 and Thymic-stromal-lymphopoeitin (TSLP) both being known to be upregulated in pruritus...
January 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29220034/just-how-good-an-investment-is-the-biopharmaceutical-sector
#11
Richard T Thakor, Nicholas Anaya, Yuwei Zhang, Christian Vilanilam, Kien Wei Siah, Chi Heem Wong, Andrew W Lo
Uncertainty surrounding the risk and reward of investments in biopharmaceutical companies poses a challenge to those interested in funding such enterprises. Using data on publicly traded stocks, we track the performance of 1,066 biopharmaceutical companies from 1930 to 2015-the most comprehensive financial analysis of this sector to date. Our systematic exploration of methods for distinguishing biotech and pharmaceutical companies yields a dynamic, more accurate classification method. We find that the performance of the biotech sector is highly sensitive to the presence of a few outlier companies, and confirm that nearly all biotech companies are loss-making enterprises, exhibiting high stock volatility...
December 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/29208530/analytical-performances-of-simultaneous-detection-of-hiv-1-hiv-2-and-hepatitis-c-specific-antibodies-and-hepatitis-b-surface-antigen-hbsag-by-multiplex-immunochromatographic-rapid-test-with-serum-samples-a-cross-sectional-study
#12
Leman Robin, Ralph-Sydney Mboumba Bouassa, Zita Aleyo Nodjikouambaye, Laura Charmant, Mathieu Matta, Sylvie Simon, Mounir Filali, Souleymane Mboup, Laurent Bélec
BACKGROUND: The HIV/HCV/HBsAg Triplex consists in manually performed, visually interpreted, lateral flow, immunochromatographic rapid diagnostic test simultaneously detecting in 15min human immunodeficiency virus (HIV)-1 and HIV-2 and hepatitis C virus (HCV)- specific antibodies (Ab) (IgG and IgM) and hepatitis B virus (HBV) surface antigen (HBsAg) in serum, plasma and whole blood. METHODS: A hospital-based cross-sectional study was conducted on a prospective panel of serum samples from adult inpatients included from routine analysis irrespectively of age and sex, including 250 sera positive for HIV-1-specific Ab, 250 for HCV-specific Ab, 250 for HBsAg and 250 sera negative for HIV- and HCV- Ab and HBsAg, and from 110 HIV-2-infected patients living in Ivory Coast, according to the results obtained by the reference chemiluminiscent microparticle immunoassay (CMIA) Abbott Architect i2000SR analyzer (Abbott Diagnostic, Chicago, IL, USA)...
December 5, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/29205444/switching-from-infliximab-innovator-to-biosimilar-in-patients-with-inflammatory-bowel-disease-a-12-month-multicentre-observational-prospective-cohort-study
#13
E M H Schmitz, P J Boekema, J W A Straathof, D C van Renswouw, L Brunsveld, V Scharnhorst, M E C van de Poll, M A C Broeren, L J J Derijks
BACKGROUND: Infliximab biosimilars have become available for treatment of inflammatory bowel disease (IBD). However, data showing long-term safety and effectiveness of biosimilars in IBD patients are limited. AIM: To study prospectively the switch from infliximab innovator to biosimilar in an IBD cohort with 12 months follow-up to evaluate safety and effectiveness. METHODS: Adult IBD patients from two hospitals treated with infliximab innovator (Remicade; Janssen Biotech,  Horsham ,  Pennsylvania, USA) were switched to infliximab biosimilar (Inflectra; Hospira, Lake Forest, Illinois, USA) as part of routine care, but in a controlled setting...
December 5, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29203739/4-and-6-interleukin-s-action-in-the-pathogenesis-of-periodontitis-gingivitis-and-dental-alveolitis
#14
Alla I Berezniakova, Valentуna F Cheremisina
INTRODUCTION: The paper presents the results of studying the role of interleukins 4 and 6 in the pathogenesis of periodontal tissue diseases, specifically, in periodontitis, gingivitis and alveolitis. THE AIM: To study the nature of participation of IL-4 and IL-6 in the mechanisms of development of periodontitis, gingivitis and alveolitis. MATERIALS AND METHODS: Studies were carried out on 80 nonlinear male rats with a body weight of 200.0 to 220...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29196435/leaving-the-bench-and-finding-your-foundation
#15
REVIEW
John E Spiro
Scientists who leave the laboratory bench to work for biomedical foundations mobilize and focus resources on the most promising research behind a foundation's mission. They acquire a broad view of a field, interact closely with research scientists at meetings and laboratory visits, and often manage proposal review boards and monitor grant progress. Increasingly, scientists at foundations also have a more active role in catalyzing research: They are involved in organizing targeted workshops, setting research priorities, and directly creating and managing resources for a scientific community...
December 1, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/29195256/increased-postprandial-glucagon-like-peptide-1-glp-1-production-after-endoscopic-gastrointestinal-bypass-using-the-cousin-lumen-apposing-stent-in-a-porcine-model
#16
Robert Caiazzo, Julien Branche, Mehdi Daoudi, Gilles Solecki, Thomas Hubert, Audrey Quenon, Violeta Raverdy, François Cousin, François Henin, Valery Dalle, Stéphane Noel, Geoffroy Vanbiervliet, Marc Barthet, François Pattou
Background and study aims Endoscopic techniques have demonstrated their effectiveness in metabolic surgery, notably through a gastrointestinal (GI) liner, with a less invasive approach than conventional surgery. Our study evaluates the safety and efficacy of endoscopic GI anastomosis (EGIA) using a lumen-apposing stent to secure the anastomosis. Materials and methods EGIA was performed using the transgastric approach with a two-channel endoscope with a novel stent (Cousin Biotech). First, a safety study with a follow-up of 12 months was performed on five piglets...
December 1, 2017: Endoscopy
https://www.readbyqxmd.com/read/29189159/oncorine-the-world-first-oncolytic-virus-medicine-and-its-update-in-china
#17
Min Liang
The oncolytic viruses now hold a promise of new therapeutic strategy for cancer. Its concept has inspired a wave of commercial research and development activities for the products of this category in China since 1998. The first commercialized oncolytic virus product in the world, Oncorine (H101), developed by Shanghai Sunway Biotech Co., Ltd since 1999, was approved by Chinese SFDA in November, 2005 for nasopharyngeal carcinoma in combination with chemotherapy after the phase III clinical trial, and finally acquired GMP certificate in August, 2006...
November 29, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29181787/what-does-unpaid-consultant-signify-a-survey-of-euphemistic-language-in-conflict-of-interest-declarations
#18
David B Menkes, Jill D Masters, Angela Bröring, Alan Blum
BACKGROUND AND OBJECTIVE: Inadequate competing interest declarations present interpretive challenges for editors, reviewers, and readers. We systematically studied a common euphemism, 'unpaid consultant,' to determine its occurrence in declarations and its association with vested interests, authors, and journals. METHODS: We used Google Scholar, a search engine that routinely includes disclosures, to identify 1164 occurrences and 787 unique biomedical journal publications between 1994 and 2014 that included one or more authors declaring themselves as an "unpaid consultant...
November 27, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29175131/sacrocolpopexy-with-polyvinylidene-fluoride-mesh-for-pelvic-organ-prolapse-mid-term-comparative-outcomes-with-polypropylene-mesh
#19
Raffaele Balsamo, Ester Illiano, Alessandro Zucchi, Franca Natale, Antonio Carbone, Marco De Sio, Elisabetta Costantini
OBJECTIVE: The aim of this study was to compare the surgical, anatomical, and functional outcomes of sacrocolpopexy (SCP) using polyvinylidene fluoride (PVDF) mesh versus SCP using the standard polypropylene (PP) mesh. STUDY DESIGN: This was a retrospective single centre case-control study including female patients who underwent laparoscopic or abdominal SCP for POP with either PP (Cousin Biotech®) or PVDF (DynaMesh®-PRS) mesh between March 2005 and May 2015. Anatomical outcomes were assessed by the Pelvic Organ Prolapse Quantification (POP-Q) system...
November 22, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29174176/communicating-biotech-advances-fiction-versus-reality
#20
Aleksandra Małyska, Robert Bolla, Tomasz Twardowski
Bioscience novels use selected technologies of genetic engineering and synthetic biology to create entertaining stories. These novels are usually based on scientific knowledge, but they may arouse public concerns about technology and drive public reluctance to accept innovative technologies. The scientific community must adopt more efficient communication and transparency.
November 22, 2017: Trends in Biotechnology
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