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Immunosupression

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https://www.readbyqxmd.com/read/27865426/surgical-treatment-of-acute-diverticulitis-a-retrospective-multicentre-study
#1
José Vicente Roig, Antonio Salvador, Matteo Frasson, Míriam Cantos, Celia Villodre, Zutoia Balciscueta, Rafael García-Calvo, Javier Aguiló, Juan Hernandis, Rodolfo Rodríguez, Francisco Landete, Eduardo García-Granero
INTRODUCTION: To analyze short and medium-term results of different surgical techniques in the treatment of complicated acute diverticulitis (CAD). METHODS: Multicentre retrospective study including patients operated on as surgical emergency or deferred-urgency with the diagnosis of CAD. RESULTS: A series of 385 patients: 218 men and 167 women, mean age 64.4±15.6 years, operated on in 10 hospitals were included. The median (25(th)-75(th) percentile) time from symptoms to surgery was 48 (24-72) h, being peritonitis the main surgical indication in a 66% of cases...
November 16, 2016: Cirugía Española
https://www.readbyqxmd.com/read/27865134/polychromatic-light-480-3400nm-similar-to-the-terrestrial-solar-spectrum-without-its-uv-component-in-post-surgical-immunorehabilitation-of-breast-cancer-patients
#2
Natalia A Zhevago, Alexander A Zimin, Tatyana V Glazanova, Natalia I Davydova, Natalia V Bychkova, Zhanna V Chubukina, Anna I Buinyakova, Marina F Ballyuzek, Kira A Samoilova
To this day, two methods of phototherapy (PT) have been successfully used in post-surgical immunorehabilitation of patients with breast cancer (BC): intravenous laser irradiation of the patients' blood and reinfusion of lympholeukosuspension of BC patients after single irradiation with HeNe laser. The objective of this pilot experimental study was to verify the effectiveness of the percutaneous use of polychromatic visible light combined with polychromatic infrared (pVIS+pIR) radiation similar to the major components of natural solar spectrum in post-surgical management of BC patients...
November 5, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27789456/hydroxylases-regulate-intestinal-fibrosis-through-the-suppression-of-erk-mediated-tgf-%C3%AE-1-signaling
#3
Mario C Manresa, Murtaza M Tambuwala, Praveen Radhakrishnan, Jonathan M Harnoss, Eric Brown, Miguel A Cavadas, Ciara E Keogh, Alex Cheong, Kim E Barrett, Eoin P Cummins, Martin Schneider, Cormac T Taylor
Fibrosis is a complication of chronic inflammatory disorders such as inflammatory bowel disease (IBD), a condition which has limited therapeutic options and often requires surgical intervention. Pharmacologic inhibition of oxygen-sensing prolyl hydroxylases (PHD), which confer oxygen-sensitivity upon the hypoxia inducible factor (HIF) pathway, has recently been shown to have therapeutic potential in colitis, although the mechanisms involved remain unclear. Here, we investigated the impact of hydroxylase inhibition on inflammation-driven fibrosis in a murine colitis model...
October 27, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27749243/the-relationship-between-vascular-biomarkers-and-disease-characteristics-in-systemic-sclerosis-elevated-mcp-1-is-predominantly-associated-with-fibrotic-manifestations
#4
Yasemin Yalçinkaya, Suzan Çinar, Bahar Artim-Esen, Sevil Kamali, Lale Öcal, Günnur Deniz, Murat Inanç
OBJECTIVES: To determine the relationship between vascular biomarkers reflecting the vascular injury and organ involvement in systemic sclerosis (SSc). METHODS: Seventy-two SSc patients (66 female) fulfilling 2013 ACR/EULAR Criteria were evaluated. Serum samples of patients were collected for flow-cytometric analysis of sCD40L, tPA, MCP-1, sE-selectin, IL-8, IL-6, VEGF, sP-selectin, TGF-β1 and VCAM levels (Bender MedSystems) in SSc patients and 20 healthy controls...
September 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27737343/oral-or-topical-administration-of-l-arginine-changes-the-expression-of-tgf-and-inos-and-results-in-early-wounds-healing
#5
Márcio Sousa Jerônimo, Adria do Prado Barros, Vinícius Elord Zen MoritaI, Erika Oliveira Alves, Nathalia Lobão Barroso de Souza, Rosane Mansan de Almeida, Yanna Karla Medeiros Nóbrega, Florêncio Figueiredo Cavalcanti, Rivadávio Amorin, Maria de Fátima Borin, Anamélia Lorenzetti Bocca
PURPOSE: To evaluate the contribution of L-arginine oral or topical rout of administration in the surgical wound healing process. METHODS: L-arginine was orally or topically administrated to mice after a laparotomy model procedure. The wounds were analyzed to evaluate the granulation tissue by HE analysis, collagen deposition, iNOS and cytokines production by immunochemisyry on wound progress. Mice used in this model were healthy, immunosupressed or diabetic and all of them were treated with different concentration of L-arginine and rout of administration...
September 2016: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/27627555/the-effect-of-p-glycoprotein-inhibition-and-activation-on-the-absorption-and-serum-levels-of-cyclosporine-and-tacrolimus-in-rats
#6
Semra Yigitaslan, Kevser Erol, Cigdem Cengelli
BACKGROUND: Permeability glycoprotein (P-glycoprotein or P-gp) plays an important role in the intestinal absorption of the immunosuppressive agents: cyclosporine and tacrolimus. OBJECTIVES: The aim of this study was to determine how the intestinal absorption of cyclosporine and tacrolimus is affected when they are used with P-gp activating or inhibiting agents. MATERIAL AND METHODS: In in vitro experiments, everted parts of rat small intestines were used to evaluate the effects of verapamil (a P-gp inhibitor) and rifampicin (a P-gp inducer) on the intestinal absorption of cyclosporine and tacrolimus...
March 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27606659/bacteremia-caused-by-rothia-mucilaginosa-after-pneumonia-in-a-patient-with-hematopoietic-stem-cell-transplantation
#7
Cihangül Bayhan, Eda Karadag Oncel, Ali B Cengiz, Ayça B Oksüz, Güzide B Aydin
Rothia muciloginosa is a member of normal flora and rarely causes invasive disease. Immunosupressed patients have increased risk for severe infection. Here, we report a male patient with relapsed neuroblastoma hospitalized for pneumonia. After clinical improvement, patient's respiratory symptoms worsened again. Rothia muciloginosa was isolated from blood culture. The worsening of respiratory symptoms can be explained by hematogenous spread of bacteria. He was successfully treated with meropenem and vancomycin for 14 days...
October 1, 2016: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/27604468/gene-therapy-based-in-antimicrobial-peptides-and-proinflammatory-cytokine-prevents-reactivation-of-experimental-latent-tuberculosis
#8
Octavio Ramos-Espinosa, Sujhey Hernández-Bazán, Alejandro Francisco-Cruz, Dulce Mata-Espinosa, Jorge Barrios-Payán, Brenda Marquina-Castillo, Fernando López-Casillas, Marta Carretero, Marcela Del Río, Rogelio Hernández-Pando
Mycobacterium tuberculosis (Mtb) latent infection can lead to reactivation. The design of new strategies to prevent it is an important subject. B6D2F1 mice were infected intratracheally with a low dose of Mtb H37Rv to induce chronic infection. After 7 months, mice were treated with one dose of recombinant adenoviruses encoding TNFα, β defensin-3 and LL37. Immunosupression was induced 1 month later with corticosterone. In comparison with the control group, mice treated with adenoviruses showed significantly less bacterial load and pneumonia, the adenoviruses encoding TNFα and LL37 being the most efficient...
October 2016: Pathogens and Disease
https://www.readbyqxmd.com/read/27580763/a-case-of-severe-chronic-inflammatory-demyelinating-polyradiculoneuropathy-with-monoclonal-gammopathy-of-undetermined-significance-with-alternating-immunoglobulin-class-to-igm-from-iga
#9
Shintaro Hayashi, Shun Nagamine, Kouki Makioka, Susumu Kusunoki, Koichi Okamoto
A 71-year-old woman with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) with IgA-λ monoclonal gammopathy of undetermined significance (MGUS) showed the acute development of tetraplegia, respiratory failure, and a marked fluctuation of the blood pressure. Intravenous (IV) high-dose steroid therapy (methylprednisolone: 1 g/day × 3 days), followed by oral prednisolone (PSL) (40 mg/day), and IV immunoglobulin (IVIg, 0.4 g/kg/day × 5 days) administrations resulted in the amelioration of these symptoms...
September 29, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/27568731/understanding-tumor-antigen-presentation-in-the-new-era-of-cancer-immunotherapy
#10
Daniela Cerezo-Wallis, Marisol Soengas
For more than a century, scientists have tried to exploit the anti-tumoral potential of the immune system to treat cancer. However, for decades all the efforts made in favor of the development of cancer immunotherapy has not had the expected clinical results. Instead, classical anti-neoplastic treatments such as surgery, radiotherapy, and chemotherapy used to be the first line of treatment. Lately, this scenario is changing, particularly with the identification of immune checkpoints inhibitors. Now more than ever, understanding how cancer cells can modulate the immune system has become a matter of great importance...
August 26, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27535863/-antithymocyte-antilymphocyte-globulin-plus-cyclosporine-a-therapy-for-the-treatment-of-older-patients-with-severe-aplastic-anemia
#11
J P Li, W R Yang, Y Li, L Ye, K Zhou, L P Jing, Y Li, G X Peng, L Song, F K Zhang, L Zhang
OBJECTIVE: To evaluate the efficacy and safety of intensive immunosupressive therapy (IST) with antithymocyte/antilymphocyte globulin plus cyclosporine A in the treatment of older patients (≥60 years) with severe aplastic anemia (SAA). METHODS: The hematologic response and safety of sixteen older SAA patients treated with IST regimen in our hospital were retrospectively analyzed , and the factors affecting response were also explored. RESULTS: A total of 16 older SAA patients were involved, the median age was 63...
July 2016: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/27458861/early-combined-immunosupression-for-the-management-of-crohn-s-disease
#12
Nilay Danış, Fatih Tekin
No abstract text is available yet for this article.
July 2016: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/27380218/cetuximab-as-treatment-for-head-and-neck-cancer-patients-with-a-previous-liver-transplant-report-of-two-cases
#13
Francia Holguin, Jordi Rubió-Casadevall, Maria Saigi, Jordi Marruecos, Miren Taberna, Marc Tobed, Manuel Maños, Ricard Mesía
Cetuximab is a monoclonal antibody against epidermal growth factor receptor useful in the treatment of patients with Head and Neck Squamous Cell Carcinoma combined with radiotherapy or chemotherapy. Its pharmacokinetics are not influenced by hepatic status and there are no specific warnings concerning its indication in patients with impaired hepatic function. Patients with a previous liver transplant are at risk for hepatic toxicity and use immunosupressants to avoid rejection that can interact with other drugs...
July 5, 2016: Journal of Chemotherapy
https://www.readbyqxmd.com/read/27345036/transcriptional-activity-of-tgf%C3%AE-1-and-its-receptors-genes-in-thyroid-gland
#14
Dariusz Kajdaniuk, Anna Marek, Bogdan Marek, Urszula Mazurek, Anna Fila-Daniłow, Wanda Foltyn, Elżbieta Morawiec-Szymonik, Lucyna Siemińśka, Mariusz Nowak, Joanna Głogowska-Szeląg, Danuta Niedziołka-Zielonka, Michał Seemann, Beata Kos-Kudła
INTRODUCTION: Determination of gene-candidates' profile expression responsible for fibrosis, immunosuppression, angiogenesis, and neoplasia processes in the pathogenesis of thyroid gland disease. MATERIAL AND METHODS: Sixty-three patients underwent thyroidectomy: 27 with non-toxic nodular goitre (NG), 22 with toxic nodular goitre (TNG), six with papillary cancer (PTC), and eight with Graves' disease (GD). In thyroid tissues, transcriptional activity of TGFbeta1 and its receptors TGFbetaRI, TGFbetaRII, and TGFbetaRIII genes were assessed using RT-qPCR (Reverse Transcriptase Quantitative Polymerase Chain Reaction)...
2016: Endokrynologia Polska
https://www.readbyqxmd.com/read/27319233/-treatment-with-rituximab-as-an-opportunity-for-the-prevention-of-infectious-complications
#15
Pavel Polák, Miroslav Penka, Petr Smejkal, Gabriela Chlupová
UNLABELLED: Rituximab, a monoclonal antibody against the surface antigen of B-lymphocytes CD20 is beeing used in the treatment of numerous hematological, hematooncological and autoimmune disorders. After administration of ritu-ximab, quick and almost complete depletion of B-lymphocytes with the exception of pre-B-lymphocytes and plasma cells occur. Neutropenia and low serum antibody levels in classes IgA, IgM and IgG may also develop. These changes usually persist for 6-12 months, rarely for several years...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27266280/evaluation-of-pulmonary-microsporidiosis-in-iatrogenically-immunosuppressed-patients
#16
Soykan Özkoç, Songül Bayram Delibaş, Çiler Akısü
INTRODUCTION: Microsporidia spp. are ubiquitous and infect a wide variety of intervertebrates and vertebrates, including humans. Pulmonary microsporidiosis, characterized by nonspecific symptoms like fever, cough and dyspnea, is often overlooked in the differential diagnosis of pulmonary infections in immunsupressed patients. In this study, we aimed to determine the prevalence of pulmonary microsporidiosis in iatrogenically immunosuppressed patients and to evaluate the patient characteristics...
December 0: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/27241253/nanofacilitated-synergistic-treatment-for-rheumatoid-arthritis-a-three-pronged-approach
#17
Shweta Pandey, Nishant Rai, Purnima Rawat, Farhan Jalees Ahmad, Sushama Talegaonkar
Rheumatoid arthritis (RA) is a chronic, inflammatory, autoimmune disease of unidentified etiology that affects the joints and causes pain, swelling, stiffness and redness in the joints. The exact cause of rheumatoid arthritis has not yet been discovered and, consequently, treatment methods have not been optimally effective. It has long been treated with anti-inflammatory and immunosupressants including modern biologics either alone or in combination but all of the drugs have severe life threatening consequences with impaired immune function due to nonspecific targeting...
July 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27238173/what-factors-may-influence-epidemiological-situation-of-tuberculosis-in-poland-and-in-the-world
#18
Ewa Rowińska-Zakrzewska, Maria Korzeniewska-Koseła, Ewa Augustynowicz-Kopeć, Monika Szturmowicz
The authors present the review of factors influencing epidemiological situation of tuberculosis in Poland and in the world. The groups of increased risk of tuberculosis, and clinical conditions predisposing to activation of latent tuberculosis infection (LTBI) such as HIV, uremia, diabetes mellitus, transplantation of organs, treatment with glucocorticosteroids and with antibodies to TNF and to its receptors, were presented. The higher prevalence and worse prognosis of tuberculosis in elderly people was emphasised...
2016: Pneumonologia i Alergologia Polska
https://www.readbyqxmd.com/read/27227446/histoplasma-capsulatum-sinusitis-possible-way-of-revelation-to-the-disseminated-form-of-histoplasmosis-in-hiv-patients-case-report-and-literature-review
#19
R Elansari, R Abada, S Rouadi, M Roubal, M Mahtar
INTRODUCTION: Histoplasma capsulatum is rarely found in nose and sinuses in immunocompetent and even in immunosupressed patients. A literature review revealed rare cases of H. capsulatum sinusitis and the case we describe in this paper is the first case of H. capsulatum sinusitis in Morocco. The purpose of our work is to present a rare case of H. capsulatum sinusitis and a literature review. CASE REPORT: A male patient, at his 39 presented to the emergency with suffered from nasal congestion and yellow postnasal rhinorrhea, occasional headaches and epistaxis for over than two months...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27208811/neutralizing-autoantibody-against-factor-xiii-a-subunit-resulted-in-severe-bleeding-diathesis-with-a-fatal-outcome-characterization-of-the-antibody
#20
K Pénzes, K Rázsó, É Katona, A Kerényi, M Kun, L Muszbek
UNLABELLED: Essentials Autoantibody against factor XIII (FXIII) is a rare but severe acquired hemorrhagic diathesis. In an elderly patient, anti-FXIII-A antibody led to severe bleedings with fatal outcome. The neutralizing autoantibody bound to FXIII with high affinity (Ka≈10(9) m(-1) ). The dominant effect of the autoantibody was the inhibition of activated FXIII. SUMMARY: Autoantibodies may develop against the catalytic A subunit of factor XIII (FXIII-A) or the carrier B subunit (FXIII-B)...
August 2016: Journal of Thrombosis and Haemostasis: JTH
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