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Immunosupression

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https://www.readbyqxmd.com/read/28275389/cd19-cd56-myeloma-arising-in-a-patient-who-failed-two-courses-of-immunosupressive-therapy-for-aplastic-anaemia
#1
Nigel P Murray, M Amparo Ruiz, G Maximiliano Miranda
Patients diagnosed with severe aplastic anaemia and without a compatible bone marrow transplant donor are treated with immunosuppressive therapy. These patients are found with time to develop a clonal disease such as myelodysplasia or paroxysmal nocturnal haemoglobinuria. However, the development of plasma cell dyscrasias is rare. We report the case here of a patient treated with immunosuppressive therapy who went on to develop myeloma 11 months after being diagnosed with severe aplastic anaemia. We include here a review of the literature...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28223762/tuberculosis-cutis-orificialis-in-adalimumab-related-immunosupressive-patient
#2
Mehdi Iskandarli, Bengu Gerceker Turk, Banu Yaman, Naim Ceylan, Can Ceylan
No abstract text is available yet for this article.
February 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28181909/visual-evoked-potentials-in-diagnostics-of-optic-neuropathy-associated-with-renal-failure
#3
Małgorzata Jurys, Sebastian Sirek, Aureliusz Kolonko, Dorota Pojda-Wilczek
Chronic renal failure is associated with many neurological complications. Due to accumulation of uremic neurotoxins axonal degeneration with its secondary demyelination occurs, which results in development of polineuropathy in 60‑100% of patients with chronic renal failure. One of the most severe peripheral neuropathy is optic neuropathy. It is associated with visual deterioration and reduction in quality of life. Symptoms of the optic neuropathy may appear either before or after dialysis therapy. They often worsen after renal transplant, probably due to immunosuppressive regimen...
January 22, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28123330/the-plethora-clinical-manifestations-and-treatment-options-of-autoimmunity-in-patients-with-primary-immunodeficiency
#4
Hatice Ezgi Barış, Ayça Kıykım, Ercan Nain, Ahmet Oğuzhan Özen, Elif Karakoç-Aydıner, Safa Barış
AIM: Although the association between primary immunodeficiency and autoimmunity is already well-known, it has once again become a topic of debate with the discovery of newly-defined immunodeficiencies. Thus, investigation of the mechanisms of development of autoimmunity in primary immunodefficiency and new target-specific therapeutic options has come to the fore. In this study, we aimed to examine the clinical findings of autoimmunity, autoimmunity varieties, and treatment responses in patients who were genetically diagnosed as having primary immunodeficiency...
December 2016: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/28120600/immediate-adverse-reactions-to-intravenous-immunoglobulin-in-children-a-single-center-experience
#5
S Kaba, G Keskindemirci, C Aydogmus, R Siraneci, F Erol Cipe
Intravenous immunoglobulin (IVIG) is commonly used in primary and secondary immunodeficiency diseases as well as autoimmune conditions as immunomodulatator treatment. Immediate adverse events which are generally mild and occur during infusion are seen in 6 hours. Reported immediate adverse events are in a wide range from 1%-40% in pediatric patients. 115 patients who received IVIG (except newborns) were included into this crosssectional study. IVIG was given to patients for primary immunodeficiencies (n=8), ITP (n=65), Kawasaki disease (n=11), secondary immunosupression (n=28), and passive immunization (n=3)...
January 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28109291/systemic-nocardiosis-in-a-dog-caused-by-nocardia-cyriacigeorgica
#6
Yesari Eroksuz, Nafia Canan Gursoy, Tolga Karapinar, Burak Karabulut, Canan Akdeniz Incili, Zeynep Yerlikaya, Zulal Asci Toraman, Mehmet Ozkan Timurkan, Hatice Eroksuz
BACKGROUND: Systemic nocardiosis due to Nocardia cyriacigeorgica has not been reported in dogs. CASE PRESENTATION: Light and electron microscopy, microbiological culture and molecular identification (PCR) were used to diagnose systemic nocardiosis caused by Nocardia cyriacigeorgica in a 3-month-old husky dog. The postmortem changes included multifocal to coalescing, sharply circumscribed pyogranulomatous inflammation and abscess formation in lungs, liver, myocardium, spleen, kidneys, brain, and hilar lymph nodes...
January 21, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28096638/coexisting-genital-malignancies-with-tuberculosis-a-case-series-with-review-of-literature
#7
Avantika Gupta, Sangeeta Gupta, Usha Manaktala, Nita Khurana
OBJECTIVE: To study a case series of genital malignancies coexisting with genital tuberculosis. MATERIALS AND METHODS: A series of three cases with known genital malignancies were found to have coexisting genital tuberculosis on subsequent workup. RESULTS: First case was a 45 years old lady who underwent staging laparotomy for ovarian cancer. On histopathology examination, there was coexisting tuberculosis with papillary serous carcinoma. Second case was 53 years old postmenopausal lady who underwent extrafascial hysterectomy along with pelvic lymph node dissection...
October 2016: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28076364/ifn%C3%AE-regulates-activated-v%C3%AE-2-t-cells-through-a-feedback-mechanism-mediated-by-mesenchymal-stem-cells
#8
Karoline Fechter, Akaitz Dorronsoro, Emma Jakobsson, Izaskun Ferrin, Valérie Lang, Pilar Sepulveda, Daniel J Pennington, César Trigueros
γδ T cells play a role in a wide range of diseases such as autoimmunity and cancer. The majority of circulating human γδ T lymphocytes express a Vγ9Vδ2+ (Vδ2+) T cell receptor (TCR) and following activation release pro-inflammatory cytokines. In this study, we show that IFNγ, produced by Vδ2+ cells, activates mesenchymal stem cell (MSC)-mediated immunosupression, which in turn exerts a negative feedback mechanism on γδ T cell function ranging from cytokine production to proliferation. Importantly, this modulatory effect is limited to a short period of time (<24 hours) post-T cell activation, after which MSCs can no longer exert their immunoregulatory capacity...
2017: PloS One
https://www.readbyqxmd.com/read/27942181/combined-surgical-and-immunosupressive-therapy-for-encapsulating-peritoneal-sclerosis
#9
P K Bipi, N Gracious, S Kumar, J George
Encapsulating peritoneal sclerosis (EPS) is an infrequent but serious complication of long-term peritoneal dialysis with 50% mortality and lack consensus on treatment. The pathogenesis of EPS is ill understood, and diagnosis lacks specificity and relies on clinical, radiographic and microscopic evaluation. Since there is no general agreement on managing EPS, we report a case treated successfully with surgery followed by immunosuppressive therapy with tamoxifen and steroids. He later successfully underwent deceased donor renal transplantation...
November 2016: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/27935917/safety-and-efficacy-of-azathioprine-as-a-second-line-therapy-for-primary-immune-thrombocytopenic-purpura
#10
B S Poudyal, B Sapkota, G S Shrestha, S Thapalia, B Gyawali, S Tuladhar
INTRODUCTION: Immune thrombocytopenic purpura remains common blood disease in Nepal. Azathioprine is an oral immunosupressive medicine which has been used widely in various autoimmune disease and solid organ transplant patients. It is inexpensive, easily available and well tolerated medicine. This study was carried out to evaluate efficacy and safety of azathioprine as a second line medicine for primary ITP patients who were refractory to steroid therapy. METHODS: The observational, pre-post study was conducted at Government of Nepal Civil Service Hospital, Kathmandu from January to October 2014...
July 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/27865426/surgical-treatment-of-acute-diverticulitis-a-retrospective-multicentre-study
#11
José Vicente Roig, Antonio Salvador, Matteo Frasson, Míriam Cantos, Celia Villodre, Zutoia Balciscueta, Rafael García-Calvo, Javier Aguiló, Juan Hernandis, Rodolfo Rodríguez, Francisco Landete, Eduardo García-Granero
INTRODUCTION: To analyze short and medium-term results of different surgical techniques in the treatment of complicated acute diverticulitis (CAD). METHODS: Multicentre retrospective study including patients operated on as surgical emergency or deferred-urgency with the diagnosis of CAD. RESULTS: A series of 385 patients: 218 men and 167 women, mean age 64.4±15.6 years, operated on in 10 hospitals were included. The median (25(th)-75(th) percentile) time from symptoms to surgery was 48 (24-72) h, being peritonitis the main surgical indication in a 66% of cases...
December 2016: Cirugía Española
https://www.readbyqxmd.com/read/27865134/polychromatic-light-480-3400nm-similar-to-the-terrestrial-solar-spectrum-without-its-uv-component-in-post-surgical-immunorehabilitation-of-breast-cancer-patients
#12
Natalia A Zhevago, Alexander A Zimin, Tatyana V Glazanova, Natalia I Davydova, Natalia V Bychkova, Zhanna V Chubukina, Anna I Buinyakova, Marina F Ballyuzek, Kira A Samoilova
To this day, two methods of phototherapy (PT) have been successfully used in post-surgical immunorehabilitation of patients with breast cancer (BC): intravenous laser irradiation of the patients' blood and reinfusion of lympholeukosuspension of BC patients after single irradiation with HeNe laser. The objective of this pilot experimental study was to verify the effectiveness of the percutaneous use of polychromatic visible light combined with polychromatic infrared (pVIS+pIR) radiation similar to the major components of natural solar spectrum in post-surgical management of BC patients...
January 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27789456/hydroxylases-regulate-intestinal-fibrosis-through-the-suppression-of-erk-mediated-tgf-%C3%AE-1-signaling
#13
Mario C Manresa, Murtaza M Tambuwala, Praveen Radhakrishnan, Jonathan M Harnoss, Eric Brown, Miguel A Cavadas, Ciara E Keogh, Alex Cheong, Kim E Barrett, Eoin P Cummins, Martin Schneider, Cormac T Taylor
Fibrosis is a complication of chronic inflammatory disorders such as inflammatory bowel disease, a condition which has limited therapeutic options and often requires surgical intervention. Pharmacologic inhibition of oxygen-sensing prolyl hydroxylases, which confer oxygen sensitivity upon the hypoxia-inducible factor pathway, has recently been shown to have therapeutic potential in colitis, although the mechanisms involved remain unclear. Here, we investigated the impact of hydroxylase inhibition on inflammation-driven fibrosis in a murine colitis model...
December 1, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27749243/the-relationship-between-vascular-biomarkers-and-disease-characteristics-in-systemic-sclerosis-elevated-mcp-1-is-predominantly-associated-with-fibrotic-manifestations
#14
Yasemin Yalçinkaya, Suzan Çinar, Bahar Artim-Esen, Sevil Kamali, Lale Öcal, Günnur Deniz, Murat Inanç
OBJECTIVES: To determine the relationship between vascular biomarkers reflecting the vascular injury and organ involvement in systemic sclerosis (SSc). METHODS: Seventy-two SSc patients (66 female) fulfilling 2013 ACR/EULAR Criteria were evaluated. Serum samples of patients were collected for flow-cytometric analysis of sCD40L, tPA, MCP-1, sE-selectin, IL-8, IL-6, VEGF, sP-selectin, TGF-β1 and VCAM levels (Bender MedSystems) in SSc patients and 20 healthy controls...
September 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27737343/oral-or-topical-administration-of-l-arginine-changes-the-expression-of-tgf-and-inos-and-results-in-early-wounds-healing
#15
Márcio Sousa Jerônimo, Adria do Prado Barros, Vinícius Elord Zen MoritaI, Erika Oliveira Alves, Nathalia Lobão Barroso de Souza, Rosane Mansan de Almeida, Yanna Karla Medeiros Nóbrega, Florêncio Figueiredo Cavalcanti, Rivadávio Amorin, Maria de Fátima Borin, Anamélia Lorenzetti Bocca
PURPOSE: To evaluate the contribution of L-arginine oral or topical rout of administration in the surgical wound healing process. METHODS: L-arginine was orally or topically administrated to mice after a laparotomy model procedure. The wounds were analyzed to evaluate the granulation tissue by HE analysis, collagen deposition, iNOS and cytokines production by immunochemisyry on wound progress. Mice used in this model were healthy, immunosupressed or diabetic and all of them were treated with different concentration of L-arginine and rout of administration...
September 2016: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/27627555/the-effect-of-p-glycoprotein-inhibition-and-activation-on-the-absorption-and-serum-levels-of-cyclosporine-and-tacrolimus-in-rats
#16
COMPARATIVE STUDY
Semra Yigitaslan, Kevser Erol, Cigdem Cengelli
BACKGROUND: Permeability glycoprotein (P-glycoprotein or P-gp) plays an important role in the intestinal absorption of the immunosuppressive agents: cyclosporine and tacrolimus. OBJECTIVES: The aim of this study was to determine how the intestinal absorption of cyclosporine and tacrolimus is affected when they are used with P-gp activating or inhibiting agents. MATERIAL AND METHODS: In in vitro experiments, everted parts of rat small intestines were used to evaluate the effects of verapamil (a P-gp inhibitor) and rifampicin (a P-gp inducer) on the intestinal absorption of cyclosporine and tacrolimus...
March 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27606659/bacteremia-caused-by-rothia-mucilaginosa-after-pneumonia-in-a-patient-with-hematopoietic-stem-cell-transplantation
#17
Cihangül Bayhan, Eda Karadag Oncel, Ali B Cengiz, Ayça B Oksüz, Güzide B Aydin
Rothia muciloginosa is a member of normal flora and rarely causes invasive disease. Immunosupressed patients have increased risk for severe infection. Here, we report a male patient with relapsed neuroblastoma hospitalized for pneumonia. After clinical improvement, patient's respiratory symptoms worsened again. Rothia muciloginosa was isolated from blood culture. The worsening of respiratory symptoms can be explained by hematogenous spread of bacteria. He was successfully treated with meropenem and vancomycin for 14 days...
October 1, 2016: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/27604468/gene-therapy-based-in-antimicrobial-peptides-and-proinflammatory-cytokine-prevents-reactivation-of-experimental-latent-tuberculosis
#18
Octavio Ramos-Espinosa, Sujhey Hernández-Bazán, Alejandro Francisco-Cruz, Dulce Mata-Espinosa, Jorge Barrios-Payán, Brenda Marquina-Castillo, Fernando López-Casillas, Marta Carretero, Marcela Del Río, Rogelio Hernández-Pando
Mycobacterium tuberculosis (Mtb) latent infection can lead to reactivation. The design of new strategies to prevent it is an important subject. B6D2F1 mice were infected intratracheally with a low dose of Mtb H37Rv to induce chronic infection. After 7 months, mice were treated with one dose of recombinant adenoviruses encoding TNFα, β defensin-3 and LL37. Immunosupression was induced 1 month later with corticosterone. In comparison with the control group, mice treated with adenoviruses showed significantly less bacterial load and pneumonia, the adenoviruses encoding TNFα and LL37 being the most efficient...
October 2016: Pathogens and Disease
https://www.readbyqxmd.com/read/27580763/a-case-of-severe-chronic-inflammatory-demyelinating-polyradiculoneuropathy-with-monoclonal-gammopathy-of-undetermined-significance-with-alternating-immunoglobulin-class-to-igm-from-iga
#19
Shintaro Hayashi, Shun Nagamine, Kouki Makioka, Susumu Kusunoki, Koichi Okamoto
A 71-year-old woman with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) with IgA-λ monoclonal gammopathy of undetermined significance (MGUS) showed the acute development of tetraplegia, respiratory failure, and a marked fluctuation of the blood pressure. Intravenous (IV) high-dose steroid therapy (methylprednisolone: 1 g/day × 3 days), followed by oral prednisolone (PSL) (40 mg/day), and IV immunoglobulin (IVIg, 0.4 g/kg/day × 5 days) administrations resulted in the amelioration of these symptoms...
September 29, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/27568731/understanding-tumor-antigen-presentation-in-the-new-era-of-cancer-immunotherapy
#20
Daniela Cerezo-Wallis, Marisol Soengas
For more than a century, scientists have tried to exploit the anti-tumoral potential of the immune system to treat cancer. However, for decades all the efforts made in favor of the development of cancer immunotherapy has not had the expected clinical results. Instead, classical anti-neoplastic treatments such as surgery, radiotherapy, and chemotherapy used to be the first line of treatment. Lately, this scenario is changing, particularly with the identification of immune checkpoints inhibitors. Now more than ever, understanding how cancer cells can modulate the immune system has become a matter of great importance...
August 26, 2016: Current Pharmaceutical Design
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