keyword
MENU ▼
Read by QxMD icon Read
search

dysmaturity

keyword
https://www.readbyqxmd.com/read/28895475/delayed-intranasal-infusion-of-human-amnion-epithelial-cells-improves-white-matter-maturation-after-asphyxia-in-preterm-fetal-sheep
#1
Lotte G van den Heuij, Mhoyra Fraser, Suzanne L Miller, Graham Jenkin, Euan M Wallace, Joanne O Davidson, Christopher A Lear, Rebecca Lim, Guido Wassink, Alistair J Gunn, Laura Bennet
Perinatal hypoxic-ischemic (HI) brain injury remains highly associated with neurodevelopmental disability after preterm birth. There is increasing evidence that disability is linked with impaired white matter maturation, but there is no specific treatment. In this study, we evaluated whether, in preterm fetal sheep, delayed intranasal infusion of human amnion epithelial cells (hAECs) given 1, 3 and 10 days after severe HI, induced by umbilical cord occlusion for 25 min, can restore white matter maturation or reduce delayed cell loss...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28883045/breath-to-breath-variability-of-exhaled-co2-as-a-marker-of-lung-dysmaturity-in-infancy
#2
Sotirios Fouzas, Ilias Theodorakopoulos, Edgar Wilfried Delgado-Eckert, Philipp Latzin, Urs Frey
The concept of diffusional screening implies that breath-to-breath variations in CO2 clearance, when related to the variability of breathing, may contain information on the quality and utilization of the available alveolar surface. We explored the validity of the above hypothesis in a cohort of young infants of comparable post-menstrual age but born at different stages of lung maturity, namely, in term-born infants (N = 128), preterm-born infants without chronic lung disease of infancy (CLDI) (N = 53) and preterm infants with moderate/severe CLDI (N = 87)...
September 7, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28862938/microstructural-alterations-and-oligodendrocyte-dysmaturation-in-white-matter-after-cardiopulmonary-bypass-in-a-juvenile-porcine-model
#3
Gary R Stinnett, Stephen Lin, Alexandru V Korotcov, Ludmila Korotcova, Paul D Morton, Shruti D Ramachandra, Angeline Pham, Sonali Kumar, Kota Agematsu, David Zurakowski, Paul C Wang, Richard A Jonas, Nobuyuki Ishibashi
BACKGROUND: Newly developed white matter (WM) injury is common after cardiopulmonary bypass (CPB) in severe/complex congenital heart disease. Fractional anisotropy (FA) allows measurement of macroscopic organization of WM pathology but has rarely been applied after CPB. The aims of our animal study were to define CPB-induced FA alterations and to determine correlations between these changes and cellular events after congenital heart disease surgery. METHODS AND RESULTS: Normal porcine WM development was first assessed between 3 and 7 weeks of age: 3-week-old piglets were randomly assigned to 1 of 3 CPB-induced insults...
August 15, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28820417/-neurosonographical-characteristics-of-dysmature-infants-depending-on-conducted-neuroprotection
#4
A Gasparyan
The actual problem of modern obstetrics is a preterm delivery (PD), its tactics as the matter of specialists' discussions. One of the main components of "preterm delivery considerate management" is the conduction of fetus neuroprotection. Currently, the only wide spread preparation for fetus neuroprotection is magnesium sulphate, the advisability of that is criticized by several authors. The 62 neonatals of recurrent delivering women with monocarpous pregnancy, who delivered with 27-28- week gestation, were examined...
July 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28748571/follicular-porokeratosis-four-new-cases
#5
A Sud, A R Shipman, M Odeke, K Varma, M Read-Jones, R A Carr
Porokeratosis, a disorder of keratinisation, is clinically characterized by the presence of annular plaques with a surrounding keratotic ridge. Clinical variants include linear, disseminated superficial actinic, verrucous/hypertrophic, disseminated eruptive, palmoplantar and porokeratosis of Mibelli (one or two typical plaques with atrophic centre and guttered keratotic rim). All of these subtypes share the histological feature of a cornoid lamella, characterized by a column of 'stacked' parakeratosis with focal absence of the granular layer, and dysmaturation (prematurely keratinised cells in the upper spinous layer)...
July 27, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28649491/ventricular-shape-and-relative-position-abnormalities-in-preterm-neonates
#6
N Paquette, J Shi, Y Wang, Y Lao, R Ceschin, M D Nelson, A Panigrahy, N Lepore
Recent neuroimaging findings have highlighted the impact of premature birth on subcortical development and morphological changes in the deep grey nuclei and ventricular system. To help characterize subcortical microstructural changes in preterm neonates, we recently implemented a multivariate tensor-based method (mTBM). This method allows to precisely measure local surface deformation of brain structures in infants. Here, we investigated ventricular abnormalities and their spatial relationships with surrounding subcortical structures in preterm neonates...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28577352/increased-postpartum-haemorrhage-the-possible-relation-with-serotonergic-and-other-psychopharmacological-drugs-a-matched-cohort-study
#7
Hanna M Heller, Anita C J Ravelli, Andrea H L Bruning, Christianne J M de Groot, Fedde Scheele, Maria G van Pampus, Adriaan Honig
BACKGROUND: Postpartum haemorrhage is a major obstetric risk worldwide. Therefore risk factors need to be investigated to control for this serious complication. A recent systematic review and meta-analysis revealed that the use of both serotonergic and non-serotonergic antidepressants in pregnancy are associated with a higher risk of postpartum haemorrhage. However, use of antidepressants in pregnancy is often necessary because untreated depression in pregnancy is associated with adverse maternal and neonatal outcome, such as postpartum depression, preterm birth and dysmaturity...
June 2, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28542743/neuroimaging-cardiovascular-physiology-and-functional-outcomes-in-infants-with-congenital-heart-disease
#8
REVIEW
Nathalie H P Claessens, Christopher J Kelly, Serena J Counsell, Manon J N L Benders
This review integrates data on brain dysmaturation and acquired brain injury using fetal and neonatal magnetic resonance imaging (MRI), including the contribution of cardiovascular physiology to differences in brain development, and the relationship between brain abnormalities and subsequent neurological impairments in infants with congenital heart disease (CHD). The antenatal and neonatal period are critical for optimal brain development; the developing brain is particularly vulnerable to haemodynamic disturbances during this time...
September 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28538945/purpuric-drug-eruptions-caused-by-epidermal-growth-factor-receptor-inhibitors-for-non-small-cell-lung-cancer-a-clinicopathologic-study-of-32-cases
#9
Yung-Tsu Cho, Kai-Lung Chen, Yi-Shuan Sheen, Che-Wen Yang, Jau-Yu Liau, Yu-Pin Cheng, Chia-Yu Chu
Importance: Purpuric skin lesions have only rarely been reported in patients receiving epidermal growth factor receptor inhibitors. However, their clinical and histopathologic presentations have varied considerably. Objective: To characterize purpuric skin eruptions caused by epidermal growth factor receptor inhibitors. Design, Setting, and Participants: This prospective study enrolled 32 patients who presented to an integrated dermato-oncologic clinic in a tertiary referral medical center with purpuric skin lesions after using epidermal growth factor receptor inhibitors from January 1, 2013, through December 31, 2015...
September 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28487011/orthopedic-conditions-of-the-premature-and-dysmature-foal
#10
REVIEW
Michelle C Coleman, Canaan Whitfield-Cargile
Incomplete ossification of the cuboidal bones is a common finding in premature and dysmature foals, and possibly in foals with hypothyroidism. Radiographs of the carpus and tarsus should be performed in any high-risk foal to obtain a diagnosis. Goals of treatment include limiting weight bearing and exercise. The prognosis is guarded depending on the degree of incomplete ossification.
May 6, 2017: Veterinary Clinics of North America. Equine Practice
https://www.readbyqxmd.com/read/28326960/placental-pathologic-features-in-fetomaternal-hemorrhage-detected-by-flow-cytometry
#11
Natasha E Lewis, Laura Marszalek, Linda M Ernst
Background Fetomaternal hemorrhage (FMH) is a poorly understood entity that can have significant clinical effects. Flow cytometry is a reliable and relatively new method for FMH diagnosis. The objective of this study was to correlate placental pathology with FMH detected by flow cytometry. Methods All patients with available placentas and FMH flow cytometric testing performed from 2009 to 2015 were retrospectively reviewed. Cases were defined as ≥0.10% fetal red blood cells (RBCs) in the maternal circulation while controls contained <0...
March 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28275159/enduring-memory-impairments-provoked-by-developmental-febrile-seizures-are-mediated-by-functional-and-structural-effects-of-neuronal-restrictive-silencing-factor
#12
Katelin P Patterson, Jeremy M Barry, Megan M Curran, Akanksha Singh-Taylor, Gary Brennan, Neggy Rismanchi, Matias Page, Yoav Noam, Gregory L Holmes, Tallie Z Baram
In a subset of children experiencing prolonged febrile seizures (FSs), the most common type of childhood seizures, cognitive outcomes are compromised. However, the underlying mechanisms are unknown. Here we identified significant, enduring spatial memory problems in male rats following experimental prolonged FS (febrile status epilepticus; eFSE). Remarkably, these deficits were abolished by transient, post hoc interference with the chromatin binding of the transcriptional repressor neuron restrictive silencing factor (NRSF or REST)...
April 5, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28109537/clinical-factors-associated-with-cerebral-metabolism-in-term-neonates-with-congenital-heart-disease
#13
Anna Lonyai Harbison, Jodie K Votava-Smith, Sylvia Del Castillo, S Ram Kumar, Vince Lee, Vincent Schmithorst, Hollie A Lai, Sharon O'Neil, Stefan Bluml, Lisa Paquette, Ashok Panigrahy
OBJECTIVE: To determine associations between patient and clinical factors with postnatal brain metabolism in term neonates with congenital heart disease (CHD) via the use of quantitative magnetic resonance spectroscopy. STUDY DESIGN: Neonates with CHD were enrolled prospectively to undergo pre- and postoperative 3T brain magnetic resonance imaging. Short-echo single-voxel magnetic resonance spectroscopy of parietal white matter was used to quantify metabolites related to brain maturation (n-acetyl aspartate, choline, myo- inositol), neurotransmitters (glutamate and gamma-aminobutyric acid), energy metabolism (glutamine, citrate, glucose, and phosphocreatine), and injury/apoptosis (lactate and lipids)...
April 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28051267/reduced-expression-of-scf-in-serum-and-follicle-from-patients-with-polycystic-ovary-syndrome
#14
J Tan, X-Y Wen, Q Su, Z-H Huang, J-X He, C-L Xin, Q-F Wu, Y Zou
OBJECTIVE: In humans, stem cell factor (SCF), produced by cumulus granulosa cells during the follicular phase, plays a crucial role in follicular development. Remarkably, polycystic ovary syndrome (PCOS), one of the main reasons affecting women fertility, is accompanied by some abnormal follicles. Is there a relationship between SCF and PCOS? This study aimed to compare the expression of SCF in follicle and serum from patients with and without PCOS undergoing in vitro fertilization (IVF) treatment and to investigate the potential relationship between aberrant SCF expression and PCOS...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27933512/effect-of-chinese-medicine-treatment-based-on-pattern-identification-on-cellular-immunophenotype-of-myelodysplastic-syndrome
#15
Yu Zhang, Li-Li Qian, Jian-Ping Shen, Jun-Fa Chen, Yan-Ting Gao, Jing-Jing Xiang, Bao-Dong Ye, Yu-Hong Zhou
OBJECTIVE: To observe the influence of treatment based on Chinese medicine pattern identification on cellular immunophenotype of the myelodysplastic syndrome (MDS). METHODS: Sixty patients with MDS were randomly and equally assigned to the treatment group and the control group using a randomized digital table. Thirty patients in each group included 3 risk levels (low, moderate and high risks) with each level 10 patients according to the international prognostic scoring system...
June 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27687291/transcriptomic-regulations-in-oligodendroglial-and-microglial-cells-related-to-brain-damage-following-fetal-growth-restriction
#16
Aline Rideau Batista Novais, Hoa Pham, Yohan Van de Looij, Miguel Bernal, Jerome Mairesse, Elodie Zana-Taieb, Marina Colella, Pierre-Henri Jarreau, Julien Pansiot, Florent Dumont, Stéphane Sizonenko, Pierre Gressens, Christiane Charriaut-Marlangue, Mickael Tanter, Charlie Demene, Daniel Vaiman, Olivier Baud
Fetal growth restriction (FGR) is a major complication of human pregnancy, frequently resulting from placental vascular diseases and prenatal malnutrition, and is associated with adverse neurocognitive outcomes throughout life. However, the mechanisms linking poor fetal growth and neurocognitive impairment are unclear. Here, we aimed to correlate changes in gene expression induced by FGR in rats and abnormal cerebral white matter maturation, brain microstructure, and cortical connectivity in vivo. We investigated a model of FGR induced by low-protein-diet malnutrition between embryonic day 0 and birth using an interdisciplinary approach combining advanced brain imaging, in vivo connectivity, microarray analysis of sorted oligodendroglial and microglial cells and histology...
December 2016: Glia
https://www.readbyqxmd.com/read/27226864/infantile-dural-arteriovenous-fistula-of-the-transverse-sinus-presenting-with-ocular-symptoms-case-reports-and-review-of-literature
#17
Ahmed Elsayed Sultan, Tamer Hassan
Dural arteriovenous fistula (DAVF) of the transverse sinus with ophthalmic manifestations in young children are rare. We reviewed two cases of direct AVF of the transverse sinus with ocular manifestations managed at our institution. The first, a 2.5 years old male child presented with left exophthalmos. Angiography revealed AVF between the occipital artery and the transverse sinus. The second, a 2 years old female child, complained of left exophthalmos. Imaging studies showed bilateral direct AVFs of the transverse sinus with bilateral dysmaturation of the sigmoid sinus...
May 2016: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/27076193/growth-charting-of-brain-connectivity-networks-and-the-identification-of-attention-impairment-in-youth
#18
Daniel Kessler, Michael Angstadt, Chandra Sripada
IMPORTANCE: Intrinsic connectivity networks (ICNs), important units of brain functional organization, demonstrate substantial maturation during youth. In addition, interrelationships between ICNs have been reliably implicated in attention performance. It is unknown whether alterations in ICN maturational profiles can reliably detect impaired attention functioning in youth. OBJECTIVE: To use a network growth charting approach to investigate the association between alterations in ICN maturation and attention performance...
May 1, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27061356/cortical-thickness-change-in-autism-during-early-childhood
#19
Elizabeth Smith, Audrey Thurm, Deanna Greenstein, Cristan Farmer, Susan Swedo, Jay Giedd, Armin Raznahan
Structural magnetic resonance imaging (MRI) scans at high spatial resolution can detect potential foci of early brain dysmaturation in children with autism spectrum disorders (ASD). In addition, comparison between MRI and behavior measures over time can identify patterns of brain change accompanying specific outcomes. We report structural MRI data from two time points for a total of 84 scans in children with ASD and 30 scans in typical controls (mean age time one = 4.1 years, mean age at time two = 6...
July 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27042238/specific-pattern-of-maturation-and-differentiation-in-the-formation-of-cortical-tubers-in-tuberous-sclerosis-omplex-tsc-evidence-from-layer-specific-marker-expression
#20
Angelika Mühlebner, Anand M Iyer, Jackelien van Scheppingen, Jasper J Anink, Floor E Jansen, Tim J Veersema, Kees P Braun, Wim G M Spliet, Wim van Hecke, Figen Söylemezoğlu, Martha Feucht, Pavel Krsek, Josef Zamecnik, Christian G Bien, Tilman Polster, Roland Coras, Ingmar Blümcke, Eleonora Aronica
BACKGROUND: Tuberous sclerosis complex (TSC) is a multisystem disorder that results from mutations in the TSC1 or TSC2 genes, leading to constitutive activation of the mammalian target of rapamycin (mTOR) signaling pathway. Cortical tubers represent typical lesions of the central nervous system (CNS) in TSC. The pattern of cortical layering disruption observed in brain tissue of TSC patients is not yet fully understood, and little is known about the origin and phenotype of individual abnormal cell types recognized in tubers...
2016: Journal of Neurodevelopmental Disorders
keyword
keyword
33607
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"