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https://www.readbyqxmd.com/read/28433781/prevalence-of-celiac-disease-autoimmunity-among-adolescents-and-young-adults-in-china
#1
Juanli Yuan, Chunyan Zhou, Jinyan Gao, Jingjing Li, Fenglian Yu, Jun Lu, Xin Li, Xiaozhong Wang, Ping Tong, Zhihua Wu, Anshu Yang, Yonghong Yao, Sarah Nadif, Heng Shu, Jiang Xu, Yujie Wu, Luud Gilissen, Hongbing Chen
BACKGROUND & AIMS: In China, epidemiological information on celiac disease autoimmunity is scarce and fragmented. We investigated the prevalence of celiac disease autoimmunity in the general Chinese population. METHODS: In a cross-sectional prospective study, 19,778 undiagnosed Chinese adolescents and young adults (16-25 years old) were recruited from consecutive new students who underwent routine physical examinations at 2 universities in Jiangxi, China from Sep...
April 19, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28432209/a-prospective-observational-cohort-study-of-the-seasonal-dynamics-of-airway-pathogens-in-the-aetiology-of-exacerbations-in-copd
#2
Tom M A Wilkinson, Emmanuel Aris, Simon Bourne, Stuart C Clarke, Mathieu Peeters, Thierry G Pascal, Sonia Schoonbroodt, Andrew C Tuck, Viktoriya Kim, Kristoffer Ostridge, Karl J Staples, Nicholas Williams, Anthony Williams, Stephen Wootton, Jeanne-Marie Devaster
BACKGROUND: The aetiology of acute exacerbations of COPD (AECOPD) is incompletely understood. Understanding the relationship between chronic bacterial airway infection and viral exposure may explain the incidence and seasonality of these events. METHODS: In this prospective, observational cohort study (NCT01360398), patients with COPD aged 40-85 years underwent sputum sampling monthly and at exacerbation for detection of bacteria and viruses. Results are presented for subjects in the full cohort, followed for 1 year...
April 21, 2017: Thorax
https://www.readbyqxmd.com/read/28431731/pericardial-conduit-for-pulmonary-artery-reconstruction-by-surgical-stapling
#3
Noriyuki Matsutani, Eiichi Kanai, Ryutaro Hanawa, Yusuke Takahashi, Hirofumi Uehara, Hisae Iinuma, Masafumi Kawamura
Pulmonary artery reconstruction in lung cancer surgery is an effective surgical method to avoid pneumonectomy that leads to longer survival times with few adverse effects. The pericardium is often used for the interposition of a prosthetic conduit. A pericardial conduit can be easily and precisely constructed by surgical stapling, which facilitates pulmonary artery reconstruction. In this report, the process and pitfalls of surgical stapling are described.
May 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28429910/dietary-patterns-and-their-associations-with-energy-nutrient-intake-and-socioeconomic-factors-in-rural-lactating-mothers-in-tibet
#4
Zhenjie Wang, Shaonong Dang, Yuan Xing, Qiang Li, Hong Yan
BACKGROUND AND OBJECTIVES: There is very limited published data on Tibetan dietary patterns and its association with nutrient intakes and socioeconomic factors. The aim of this study was to identify and describe the dietary patterns and the associations with nutrient intakes in rural Tibetan pregnant, lactating mothers. METHODS AND STUDY DESIGN: Dietary patterns and nutrient intakes were identified via a food frequency questionnaire (FFQ). We identified dietary patterns using principle component analysis (PCA) of intakes of 17 food groups and specific Tibetan foods...
May 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28428706/gastroesophageal-reflux-disease-and-morbid-obesity-to-sleeve-or-not-to-sleeve
#5
EDITORIAL
Fabrizio Rebecchi, Marco E Allaix, Marco G Patti, Francisco Schlottmann, Mario Morino
Laparoscopic sleeve gastrectomy (LSG) has reached wide popularity during the last 15 years, due to the limited morbidity and mortality rates, and the very good weight loss results and effects on comorbid conditions. However, there are concerns regarding the effects of LSG on gastroesophageal reflux disease (GERD). The interpretation of the current evidence is challenged by the fact that the LSG technique is not standardized, and most studies investigate the presence of GERD by assessing symptoms and the use of acid reducing medications only...
April 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28427093/video-assisted-thoracic-surgical-right-upper-lobectomy-with-bronchus-first-and-simultaneous-vessel-stapling-technique
#6
Linyou Zhang, Hao Xu
No abstract text is available yet for this article.
April 20, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28426641/notes-from-the-field-powassan-virus-disease-in-an-infant-connecticut-2016
#7
Jessica W Tutolo, J Erin Staples, Lynn Sosa, Nicholas Bennett
No abstract text is available yet for this article.
April 21, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28425639/designing-dual-inhibitors-of-mdm2-mdmx-unexpected-coupling-of-water-with-gatekeeper-y100-99
#8
Xiong An Lee, Chandra Verma, Adelene Y L Sim
Mdm2 and MdmX share high structural similarity in their N-terminal domains, yet dual inhibitors are challenging to design due to differences in the conformations of the binding pockets, and notably of the proposed gatekeeper residue, Y100/99. Analysis of crystal structures and molecular dynamics (MD) simulations of complexes of Mdm2 and MdmX resulted in the identification of a water molecule with a long residence time that appears to be modulated by the conformation of Y100/99. These observations lead us to speculate that dual inhibitors either i) stabilize both Mdm2 and MdmX with Y100/99 in the open conformation typically seen in complexes of Mdm2 with p53, or ii) the dual inhibitors are agnostic to the conformation of Y100/99...
April 20, 2017: Proteins
https://www.readbyqxmd.com/read/28425110/neural-tube-defects-risk-factors-and-preventive-measures
#9
REVIEW
Atsuo Kondo, Takuya Matsuo, Nobuhito Morota, Atsuya S Kondo, Ikuyo Okai, Hiromi Fukuda
For the last 25 years, it has been proven that the occurrence or recurrence of neural tube defects can be prevented with the administration of folic acid before and early pregnancy. At present, over 80 countries in the world, except Japan, have mandated the fortification of wheat flour and/or rice with folic acid, which has resulted in a significant reduction in the prevalence of neural tube defects. In 2000, the Japanese government recommended folic acid 400 µg daily for young women of childbearing age and women who are planning to conceive...
April 19, 2017: Congenital Anomalies
https://www.readbyqxmd.com/read/28424769/folates-in-plants-research-advances-and-progress-in-crop-biofortification
#10
REVIEW
Vera Gorelova, Lars Ambach, Fabrice Rébeillé, Christophe Stove, Dominique Van Der Straeten
Folates, also known as B9 vitamins, serve as donors and acceptors in one-carbon (C1) transfer reactions. The latter are involved in synthesis of many important biomolecules, such as amino acids, nucleic acids and vitamin B5. Folates also play a central role in the methyl cycle that provides one-carbon groups for methylation reactions. The important functions fulfilled by folates make them essential in all living organisms. Plants, being able to synthesize folates de novo, serve as an excellent dietary source of folates for animals that lack the respective biosynthetic pathway...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/28424497/the-glycogen-synthase-kinase-mogsk1-regulated-by-mps1-map-kinase-is-required-for-fungal-development-and-pathogenicity-in-magnaporthe-oryzae
#11
Tengsheng Zhou, Yasin F Dagdas, Xiaohan Zhu, Shiqin Zheng, Liqiong Chen, Zachary Cartwright, Nicholas J Talbot, Zonghua Wang
Magnaporthe oryzae, the causal agent of blast disease, is one of the most destructive plant pathogens, causing significant yield losses on staple crops such as rice and wheat. The fungus infects plants with a specialized cell called an appressorium, whose development is tightly regulated by MAPK signaling pathways following the activation of upstream sensors in response to environmental stimuli. Here, we show the expression of the Glycogen synthase kinase 3 (GSK3) MoGSK1 in M. oryzae is regulated by Mps1 MAP kinase, particularly under the stressed conditions...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28424260/upregulation-of-zinc-absorption-matches-increases-in-physiologic-requirements-for-zinc-in-women-consuming-high-or-moderate-phytate-diets-during-late-pregnancy-and-early-lactation
#12
K Michael Hambidge, Leland V Miller, Manolo Mazariegos, Jamie Westcott, Noel W Solomons, Victor Raboy, Jennifer F Kemp, Abhik Das, Norman Goco, Ty Hartwell, Linda Wright, Nancy F Krebs
Background: Estimated physiologic requirements (PRs) for zinc increase in late pregnancy and early lactation, but the effect on dietary zinc requirements is uncertain.Objective: The aim of this study was to determine changes in daily fractional absorbed zinc and total absorbed zinc (TAZ) from ad libitum diets of differing phytate contents in relation to physiologic zinc requirements during pregnancy and lactation.Methods: This was a prospective observational study of zinc absorption at 8 (phase 1) and 34 (phase 2) wk of gestation and 2 (phase 3) and 6 (phase 4) mo of lactation...
April 19, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28416819/cassava-haplotype-map-highlights-fixation-of-deleterious-mutations-during-clonal-propagation
#13
Punna Ramu, Williams Esuma, Robert Kawuki, Ismail Y Rabbi, Chiedozie Egesi, Jessen V Bredeson, Rebecca S Bart, Janu Verma, Edward S Buckler, Fei Lu
Cassava (Manihot esculenta Crantz) is an important staple food crop in Africa and South America; however, ubiquitous deleterious mutations may severely decrease its fitness. To evaluate these deleterious mutations, we constructed a cassava haplotype map through deep sequencing 241 diverse accessions and identified >28 million segregating variants. We found that (i) although domestication has modified starch and ketone metabolism pathways to allow for human consumption, the concomitant bottleneck and clonal propagation have resulted in a large proportion of fixed deleterious amino acid changes, increased the number of deleterious alleles by 26%, and shifted the mutational burden toward common variants; (ii) deleterious mutations have been ineffectively purged, owing to limited recombination in the cassava genome; (iii) recent breeding efforts have maintained yield by masking the most damaging recessive mutations in the heterozygous state but have been unable to purge the mutation burden; such purging should be a key target in future cassava breeding...
April 17, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28415434/design-and-development-of-a-hybrid-bioartificial-water-induced-shape-memory-polymeric-material-as-an-integral-component-for-the-anastomosis-of-human-hollow-organs
#14
Siriana Paonessa, Niccoletta Barbani, Elisa Cibrario Rocchietti, Claudia Giachino, Caterina Cristallini
A large number of pathologies require the resection of the bowel and anastomoses to rejoin the two remaining stumps to regain lumen patency. Various materials have been used to rejoin one bowel end to the other such as catgut, stainless steel, and absorbable sutures. The present method for anastomosis surgery uses an entero-entero anastomosis (EEA) circular stapler with only a staple line. This method can have some drawbacks, such as intracellular fluid leakage and local inflammations. The aim of this study is to design and develop a novel bioartificial polymer with a ring shape made of polyvinyl alcohol (PVA) and gelatin (80/20 ratio (w/w)) loaded both directly with acetylsalicylic acid and with nanoparticles incorporating the same drug to reduce local inflammation even for a prolonged period of time...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28414614/intracorporeal-circular-stapled-esophagojejunostomy-using-conventional-purse-string-suture-instrument-after-laparoscopic-total-gastrectomy
#15
Weiguo Liu, Yongfang Guo, Zhigang Qiu, Dongguang Niu, Jianli Zhang
BACKGROUND: An optimal alimentary tract reconstruction technique after laparoscopic total gastrectomy (LTG) remains controversial. The authors developed a new simple technique for intracorporeal esophagojejunal anastomosis that employs a conventional purse-string suture instrument (PSI) and circular stapler. METHODS: From May 2014 to April 2016, 41 consecutive patients with gastric cancer underwent LTG in the author's institution. Intracorporeal esophagojejunal anastomosis using the following method was attempted for all patients...
April 17, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28414527/advantages-and-limitations-of-in-vitro-and-in-vivo-methods-of-iron-and-zinc-bioavailability-evaluation-in-the-assessment-of-biofortification-program-effectiveness
#16
Desirrê Morais Dias, Neuza Maria Brunoro Costa, Marilia Regini Nutti, Elad Tako, Hércia Stampini Duarte Martino
Biofortification aims to improve the micronutrient concentration of staple food crops through the best practices of breeding and modern biotechnology. However, increased zinc and iron concentrations in food crops may not always translate into proportional increases in absorbed zinc (Zn) and iron (Fe). Therefore, assessing iron and zinc bioavailability in biofortified crops is imperative to evaluate the efficacy of breeding programs. This review aimed to investigate the advantages and limitations of in vitro and in vivo methods of iron and zinc bioavailability evaluation in the assessment of biofortification program effectiveness...
April 17, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28414223/diversity-oriented-stapling-yields-intrinsically-cell-penetrant-inducers-of-autophagy
#17
Leila Peraro, Zhongju Zou, Kamlesh M Makwana, Ashleigh Cummings, Haydn L Ball, Hongtao Yu, Yu-Shan Lin, Beth Levine, Joshua A Kritzer
Autophagy is an essential pathway by which cellular and foreign material are degraded and recycled in eukaryotic cells. Induction of autophagy is a promising approach for treating diverse human diseases, including neurodegenerative disorders and infectious diseases. Here, we report the use of a diversity-oriented stapling approach to produce autophagy-inducing peptides that are intrinsically cell-penetrant. These peptides induce autophagy at micromolar concentrations in vitro, have aggregate-clearing activity in a cellular model of Huntington's disease, and induce autophagy in vivo...
April 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28413251/food-price-seasonality-in-africa-measurement-and-extent
#18
Christopher L Gilbert, Luc Christiaensen, Jonathan Kaminski
Everyone knows about seasonality. But what exactly do we know? This study systematically measures seasonal price gaps at 193 markets for 13 food commodities in seven African countries. It shows that the commonly used dummy variable or moving average deviation methods to estimate the seasonal gap can yield substantial upward bias. This can be partially circumvented using trigonometric and sawtooth models, which are more parsimonious. Among staple crops, seasonality is highest for maize (33 percent on average) and lowest for rice (16½ percent)...
February 2017: Food Policy
https://www.readbyqxmd.com/read/28411792/surgical-staples-for-hemostasis-during-scalp-surgery
#19
Eduardo Varas-Meis, Noemí Eiris, Manuel-Ángel Rodríguez-Prieto
No abstract text is available yet for this article.
May 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28408988/sutureless-functional-end-to-end-anastomosis-using-a-linear-stapler-with-polyglycolic-acid-felt-for-intestinal-anastomoses
#20
Masanori Naito, Hirohisa Miura, Takatoshi Nakamura, Takeo Sato, Takahiro Yamanashi, Atsuko Tsutsui, Masahiko Watanabe
BACKGROUND: Gastrointestinal anastomosis remains associated with a considerable burden of morbidity and, in some cases, mortality. Functional end-to-end anastomosis, whilst extremely efficient, is vulnerable to increased intestinal pressure in the immediate postoperative period, which may predispose to development of anastomotic leakage or bleeding. Therefore, there is a requirement for new techniques that facilitate safe and efficacious anastomotic procedures. MATERIALS AND METHODS: This study examined the clinical application of functional end-to-end anastomosis with a stapler that automatically applies a bioabsorbable polyglycolic acid sheet (Endo GIA™ Reinforced Reload with Tri-Staple™ Technology)...
May 2017: Annals of Medicine and Surgery
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