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https://www.readbyqxmd.com/read/29676504/3d-dna-origami-nanoparticles-from-basic-design-principles-to-emerging-applications-in-soft-matter-and-bio-nanosciences
#1
Andreas Walther, Sebastian Loescher, Saskia Groeer
Scaffold-based lattice-engineered 3D DNA origami emerges as a powerful and versatile technique for the rational design and built-up of arbitrary and monodisperse DNA-based 3D nanoobjects. Relying on the unsurpassed molecular programmability of sequence-specific DNA hybridization, a long circular ssDNA strand (termed scaffold) is assembled with many short ssDNA oligomers (termed staples), which organize the scaffold into a 3D lattice in a single step leading to highest precision 3D nanoparticulate structures with high yields...
April 20, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29674152/identification-and-functional-analysis-of-the-aspergillic-acid-gene-cluster-in-aspergillus-flavus
#2
Matthew D Lebar, Jeffrey W Cary, Rajtilak Majumdar, Carol H Carter-Wientjes, Brian M Mack, Qijian Wei, Valdet Uka, Sarah De Saeger, José Diana Di Mavungu
Aspergillus flavus can colonize important food staples and produce aflatoxins, a group of toxic and carcinogenic secondary metabolites. Previous in silico analysis of the A. flavus genome revealed 56 gene clusters predicted to be involved in the biosynthesis of secondary metabolites. A. flavus secondary metabolites produced during infection of maize seed are of particular interest, especially with respect to their roles in the biology of the fungus. A predicted nonribosomal peptide synthetase-like (NRPS-like) gene, designated asaC (AFLA_023020), present in the uncharacterized A...
April 16, 2018: Fungal Genetics and Biology: FG & B
https://www.readbyqxmd.com/read/29671834/using-peptidomimetics-and-constrained-peptides-as-valuable-tools-for-inhibiting-protein%C3%A2-protein-interactions
#3
REVIEW
Naomi S Robertson, David R Spring
Protein⁻protein interactions (PPIs) are tremendously important for the function of many biological processes. However, because of the structure of many protein⁻protein interfaces (flat, featureless and relatively large), they have largely been overlooked as potential drug targets. In this review, we highlight the current tools used to study the molecular recognition of PPIs through the use of different peptidomimetics, from small molecules and scaffolds to peptides. Then, we focus on constrained peptides, and in particular, ways to constrain α-helices through stapling using both one- and two-component techniques...
April 19, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29671831/the-potential-of-integrating-provitamin-a-biofortified-maize-in-smallholder-farming-systems-to-reduce-malnourishment-in-south-africa
#4
REVIEW
Mthokozisi K Zuma, Unathi Kolanisi, Albert T Modi
Biofortification interventions have the potential to combat malnutrition. This review explored the use of provitamin A-biofortified maize (PVABM) as a vitamin A deficiency (VAD) reduction agricultural-based strategy. Maize has been identified as one of the key staple crops for biofortification to reduce hidden hunger in Africa. Most nutrition interventions have not been successful in reducing hunger because rural communities, who mainly rely on agriculture, have been indirectly excluded. The biofortification intervention proposed here aims to be an inclusive strategy, based on smallholder farming systems...
April 19, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29671584/tailored-polyproteins-using-sequential-staple-and-cut
#5
Surbhi Garg, Gayathri S Singaraju, Sunanda Yengkhom, Sabyasachi Rakshit
Polyproteins, individual protein units joined covalently in tandem, have been evolved as a promising tool for measuring the dynamic folding of bio-macromolecules in single-molecule force spectroscopy. However, the synthetic routes of preparing polyproteins have been a bottleneck, and urge for developing in-vitro methods to knit individual protein units covalently into polyprotein. Employing two enzymes of orthogonal functionalities periodically in sequence, we synthesized monodispersed polyproteins on a solid surface...
April 19, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29669426/do-coffee-farmers-benefit-in-food-security-from-participating-in-coffee-cooperatives-evidence-from-southwest-ethiopia-coffee-cooperatives
#6
Zekarias Shumeta, Marijke D'Haese
BACKGROUND: Most coffee in Ethiopia is produced by smallholder farmers who face a daily struggle to get sufficient income but also to feed their families. At the same time, many smallholder coffee producers are members of cooperatives. Yet, literature has paid little attention to the effect of cooperatives on combating food insecurity among cash crop producers including coffee farmers. OBJECTIVE: The objective of the study was to investigate how coffee cooperative membership may affect food security among coffee farm households in Southwest Ethiopia...
January 1, 2018: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/29668667/effects-and-results-of-omentopexy-during-laparoscopic-sleeve-gastrectomy
#7
Ergin Arslan, Oktay Banli, Mesut Sipahi, Gokhan Yagci
PURPOSE: The aim of this study was to demonstrate that gastric volvulus can be prevented by omentopexy and sleeve gastrectomy without increasing other complication rates. MATERIALS AND METHODS: A total of 1385 patients who underwent omentopexy and sleeve gastrectomy between April 2013 and September 2017 were included this study. Body mass index, age, sex, comorbidities, and postoperative complications of the patients were recorded as data. RESULTS: A total of 1385 patients underwent sleeve gastrectomy and omentopexy...
April 17, 2018: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/29667024/double-baltazar-procedure-for-repair-of-gastric-leakage-post-sleeve-gastrectomy-from-two-sites-case-report-of-new-surgical-technique
#8
Hussein Mcheimeche, Samer H Dbouk, Riad Saheli, Dany Lichaa, Louai S Chalaby
BACKGROUND: Staple line leak is one of the most challenging complications following laparoscopic sleeve gastrectomy, with a rate reaching near 1%. Its management often implicates a multidisciplinary approach and experienced bariatric and metabolic surgeons. The literature is abundant on various approaches to treat single staple line leak with variable results. But what to do in front of an intra-op incidental finding of double gastric fistulae? METHODS: In this article, we describe a new successful surgical treatment option of double Baltazar technique for a patient who was found to have two gastric fistulae post-sleeve gastrectomy...
April 18, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29666287/the-blast-fungus-decoded-genomes-in-flux
#9
Thorsten Langner, Aleksandra Białas, Sophien Kamoun
Plant disease outbreaks caused by fungi are a chronic threat to global food security. A prime case is blast disease, which is caused by the ascomycete fungus Magnaporthe oryzae (syn. Pyricularia oryzae ), which is infamous as the most destructive disease of the staple crop rice. However, despite its Linnaean binomial name, M. oryzae is a multihost pathogen that infects more than 50 species of grasses. A timely study by P. Gladieux and colleagues (mBio 9:e01219-17, 2018, https://doi.org/10.1128/mBio.01219-17) reports the most extensive population genomic analysis of the blast fungus thus far...
April 17, 2018: MBio
https://www.readbyqxmd.com/read/29665952/community-engagement-for-paediatric-mdr-tb-clinical-trials-principles-to-support-ethical-trial-implementation
#10
G Hoddinott, S Staples, R Brown, M Simwinga, C Mubekapi-Musadaidzwa, A C Hesseling, G Hendricks, P De Koker, L McKenna
The paediatric tuberculosis (TB) prevention and treatment landscape is moving into a new and exciting era, with knowledge from clinical trials offering real benefit to children. Community engagement is key to optimising the success of these trials. However, the clinical profile, epidemiology and social perceptions for paediatric multidrug-resistant TB (MDR-TB) complicate the operationalisation of this community engagement. We reflect on a diversity of recent experiences attempting to implement this type of research and the community engagement around it...
May 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29664369/heartland-virus-and-hemophagocytic-lymphohistiocytosis-in-immunocompromised-patient-missouri-usa
#11
Abigail L Carlson, Daniel M Pastula, Amy J Lambert, J Erin Staples, Atis Muehlenbachs, George Turabelidze, Charles S Eby, Jesse Keller, Brian Hess, Richard S Buller, Gregory A Storch, Kathleen Byrnes, Louis Dehner, Nigar Kirmani, F Matthew Kuhlmann
Heartland virus is a suspected tickborne pathogen in the United States. We describe a case of hemophagocytic lymphohistiocytosis, then death, in an immunosuppressed elderly man in Missouri, USA, who was infected with Heartland virus.
May 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29663180/impact-of-powered-and-tissue-specific-endoscopic-stapling-technology-on-clinical-and-economic-outcomes-of-video-assisted-thoracic-surgery-lobectomy-procedures-a-retrospective-observational-study
#12
Daniel L Miller, Sanjoy Roy, Edmund S Kassis, Sashi Yadalam, Sushama Ramisetti, Stephen S Johnston
INTRODUCTION: Video-assisted thoracic surgery (VATS) lung resections are complex procedures with a critical role played by endoscopic staplers in the transection of vessels, bronchi, and lung tissue. This retrospective, observational study compared hospital resource use, costs, and complications of VATS lobectomy procedures for whom powered versus manual endoscopic surgical staplers were used. METHODS: Patients ≥ 18 years of age undergoing elective VATS lobectomy during an inpatient admission from January 1, 2012 to September 30, 2016 were identified from the Premier Healthcare Database (first admission = index admission)...
April 16, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29659709/progress-in-single-access-information-systems-for-wheat-and-rice-crop-improvement
#13
Armin Scheben, Chon-Kit Kenneth Chan, Locedie Mansueto, Ramil Mauleon, Pierre Larmande, Nickolai Alexandrov, Rod A Wing, Kenneth L McNally, Hadi Quesneville, David Edwards
Improving productivity of the staple crops wheat and rice is essential to feed the growing global population, particularly in the context of a changing climate. However, current rates of yield gain are insufficient to support the predicted population growth. New approaches are required to accelerate the breeding process, and many of these are driven by the application of large-scale crop data. To leverage the substantial volumes and types of data that can be applied for precision breeding, the wheat and rice research communities are working towards the development of integrated systems to access and standardize the dispersed, heterogeneous available data...
April 5, 2018: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29658617/assessment-of-salt-concentration-in-bread-commonly-consumed-in-the-eastern-mediterranean-region
#14
Ayoub Al Jawaldeh, Manal Al-Khamaiseh
Background: Hypertension is the most important cardiovascular risk factor in the World Health Organization (WHO) Eastern Mediterranean Region. Excessive salt and sodium intake is directly related to hypertension, and its reduction is a priority of WHO. Bread is the leading staple food in the Region; therefore, reducing the amount of salt added to bread could be an effective measure for reducing salt intake. Aim: The study sought to determine the levels of sodium and salt in locally produced staple bread from 8 countries in the Region...
April 5, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/29656297/reducing-mineral-and-vitamin-deficiencies-through-biofortification-progress-under-harvestplus
#15
Howarth Bouis
Fundamentally, the prevalence of mineral and vitamin deficiencies is high in developing countries due to the fact that agricultural systems do not produce sufficient foods rich in minerals and vitamins. Biofortification involves breeding staple food crops to increase their micronutrient content, targeting staple foods widely consumed by low-income families globally. In so doing, biofortification contributes to solving the underlying problem of mineral and vitamin deficiencies by increasing the amount of iron, zinc, and provitamin A produced by food systems...
April 13, 2018: World Review of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29656257/nutrient-derived-environmental-impacts-in-chinese-agriculture-during-1978-2015
#16
Huijun Wu, Shun Wang, Liangmin Gao, Ling Zhang, Zengwei Yuan, Tingyu Fan, Kaiping Wei, Li Huang
Nitrogen (N) and phosphorus (P) play a critical role in agricultural production and cause many environmental disturbances. By combing life cycle assessment (LCA) method with the mass balance principle of substance flow analysis (SFA), this study establishes a nutrient-derived environmental impact assessment (NEIA) model to analyze the environmental impacts caused by nutrient-containing substances of agricultural production in China during 1978-2015. The agricultural production system is composed of crop farming and livestock breeding, and the environmental impacts include energy consumption, global warming, acidification, and eutrophication...
April 12, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29656008/identification-of-mirnas-linked-with-the-drought-response-of-tef-eragrostis-tef-zucc-trotter
#17
Federico Martinelli, Gina Cannarozzi, Bipin Balan, Fredy Siegrist, Annett Weichert, Regula Blösch, Zerihun Tadele
Tef [Eragrostis tef (Zucc.) Trotter], a staple food crop in the Horn of Africa and particularly in Ethiopia, has several beneficial agronomical and nutritional properties, including waterlogging and drought tolerance. In this study, we performed microRNA profiling of tef using the Illumina HiSeq 2500 platform, analyzing both shoots and roots of two tef genotypes, one drought-tolerant (Tsedey) and one drought-susceptible (Alba). We obtained more than 10 million filtered reads for each of the 24 sequenced small cDNA libraries...
March 29, 2018: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29652112/mucopexy-recto-anal-lifting-mu-ral-a-standardized-minimally-invasive-method-of-managing-symptomatic-hemorrhoids-with-an-innovative-suturing-technique-and-the-hemorpex-system%C3%A2
#18
Claudio Pagano, Contardo Vergani, Carlo Invernizzi, Massimo Bussone, Guido Benegiamo, Marco Venturi
BACKGROUND: Conservative surgery of hemorrhoidal disease is less painful than traditional hemorrhoidectomy, and mucopexy has less risk of serious postoperative complications than stapled hemorrhoidopexy. The aim of this study was to evaluate the safety and effectiveness of a standardized, modified hemorrhoidopexy, named Mucopexy-Recto Anal Lifting (MuRAL),with the HemorPex System (HPS) in patients with symptomatic III and IV degree hemorrhoids. MATERIALS AND METHODS: Patients were enrolled from May 2013 to Dec 2015 and operated on with the MuRAL technique, based on arterial ligation and mucopexy at 6 locations, using a standardized clockwise/anti-clockwise rotation sequence of the HPS anoscope...
April 12, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29650459/examining-the-feasibility-of-healthy-minimum-stocking-standards-for-small-food-stores
#19
Allison Karpyn, Robin S DeWeese, Jennifer E Pelletier, Melissa N Laska, Punam Ohri-Vachaspati, Amy Deahl-Greenlaw, Ogheneruona Ughwanogho, Stephanie Bell Jilcott Pitts
OBJECTIVE: In response to recent national efforts to increase the availability of healthy food in small stores, we sought to understand the extent to which small food stores could implement the newly published Healthy Small Store Minimum Stocking Recommendations and reflect on the new US Department of Agriculture Food and Nutrition Service's final rule for stocking of staple foods for Supplemental Nutrition Assistance Program-approved retailers. DESIGN: We collected qualitative and quantitative data from 57 small stores in four states (Arizona, Delaware, Minnesota, and North Carolina) that accepted Supplemental Nutrition Assistance Program but not Special Supplemental Nutrition Assistance Program for Women, Infants, and Children benefits...
April 9, 2018: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29644949/extrinsic-iron-from-soil-contributes-to-hb-regeneration-of-anaemic-rats-implications-for-foods-contaminated-with-soil-iron
#20
Habtamu Guja, Kaleab Baye
Contamination of foods with extrinsic (soil) Fe is common in developing countries. However, the bioavailability of this extrinsic Fe and the extent to which it contributes to Fe nutrition remains unknown. The present study compared the bioavailability of laboratory- and field-threshed teff (Eragrostisis tef (Zucc) Trotter) to evaluate the bioavailablity of extrinsic soil Fe that resulted from the traditional threshing of the staple grain. Using sequential extraction, Fe was fractionated and its solubility was evaluated...
April 2018: British Journal of Nutrition
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