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https://www.readbyqxmd.com/read/29230964/preventive-effect-of-diverting-stoma-on-anastomotic-leakage-after-laparoscopic-low-anterior-resection-with-double-stapling-technique-reconstruction-applied-based-on-risk-stratification
#1
Atsushi Hamabe, Masaaki Ito, Hideaki Nishigori, Yuji Nishizawa, Takeshi Sasaki
INTRODUCTION: During laparoscopic low anterior resection with double stapling technique reconstruction, it is necessary to securely implement rectal transection and anastomosis to prevent anastomotic leakage (AL). However, risk factors and preventive measures for AL are not known sufficiently. Therefore, this study aimed to elucidate risk factors associated with AL and to clarify strategies to prevent it. METHODS: We analyzed a total of 296 cases with rectal cancer who had undergone laparoscopic low anterior resection with double stapling technique reconstruction at the National Cancer Center Hospital East...
December 12, 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29228061/structure-activity-studies-of-mdm2-mdm4-binding-stapled-peptides-comprising-non-natural-amino-acids
#2
Sharon Min Qi Chee, Jantana Wongsantichon, Jiawei Siau, Dawn Thean, Fernando Ferrer, Robert C Robinson, David P Lane, Christopher J Brown, Farid J Ghadessy
As primary p53 antagonists, Mdm2 and the closely related Mdm4 are relevant cancer therapeutic targets. We have previously described a series of cell-permeable stapled peptides that bind to Mdm2 with high affinity, resulting in activation of the p53 tumour suppressor. Within this series, highest affinity was obtained by modification of an obligate tryptophan residue to the non-natural L-6-chlorotryptophan. To understand the structural basis for improved affinity we have solved the crystal structure of this stapled peptide (M011) bound to Mdm2 (residues 6-125) at 1...
2017: PloS One
https://www.readbyqxmd.com/read/29227504/x-ray-crystal-structure-and-doping-mechanism-of-bimetallic-nanocluster-au36-xcux-m-mbt-24-x-1-3
#3
Bo Rao, Tong Zhao, Sha Yang, Jinsong Chai, Yiting Pan, Shiyin Weng, Haizhu Yu, Xiaowu Li, Manzhou Zhu
A novel Au36-xCux(m-MBT)24 (x = 1-3, m-MBT = 3-methylbenzenethiolate) nanocluster has been prepared. According to the X-ray single crystal diffractometer, the structure of Au36-xCux(m-MBT)24 is similar to that of Au36(SPhtBu)24. The Au36-xCux(m-MBT)24 nanocluster contains a face-centered cubic (FCC) M28 core, which is protected by 4 M2S3 (M = Au/Cu) staple motifs and 12 bridging SR ligands. The Cu dopants could possibly occupy 14 sites (six in the sub-surface and eight in the staple motifs). Spectral monitoring indicates that the number of Cu dopants sequentially increased on increasing the amount of Cu precursors (relative to a Au control)...
December 11, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29224865/effects-of-supplementation-with-ruminally-protected-choline-on-performance-of-multiparous-holstein-cows-did-not-depend-upon-prepartum-caloric-intake
#4
M G Zenobi, R Gardinal, J E Zuniga, A L G Dias, C D Nelson, J P Driver, B A Barton, J E P Santos, C R Staples
Objectives were to evaluate the effect of prepartum energy intake on performance of dairy cows supplemented with or without ruminally protected choline (RPC; 0 or 17.3 g/d of choline chloride; 0 or 60 g/d of ReaShure, Balchem Corp., New Hampton, NY). At 47 ± 6 d before the expected calving date, 93 multiparous Holstein cows were assigned randomly to 1 of 4 dietary treatments in a 2 × 2 factorial arrangement. Cows were fed energy to excess [EXE; 1.63 Mcal of net energy for lactation/kg of dry matter (DM)] or to maintenance (MNE; 1...
December 7, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29223632/comparative-morbidity-of-cubital-tunnel-surgeries-a-prospective-cohort-study
#5
Robert Staples, Dan London, Agnes Z Dardas, Charles A Goldfarb, Ryan P Calfee
PURPOSE: Randomized controlled trials have not identified a superior surgical approach to cubital tunnel syndrome surgery. This study evaluates the early morbidity of open in situ decompression and transposition. METHODS: This prospective cohort study enrolled 125 adult patients indicated for cubital tunnel surgery at a tertiary institution. Exclusion criteria included preoperative use of narcotics and concurrent elbow procedures. In situ decompressions (n = 47) and ulnar nerve transpositions (n = 78) were performed...
December 6, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29221648/benefit-of-using-motion-compensated-reconstructions-for-reducing-inter-observer-and-intra-observer-contouring-variation-for-organs-at-risk-in-lung-cancer-patients
#6
A McWilliam, L Lee, M Harris, H Sheikh, L Pemberton, C Faivre-Finn, M van Herk
BACKGROUND AND PURPOSE: In lung cancer patients, accuracy in contouring is hampered by image artefacts introduced by respiratory motion. With the widespread introduction of 4DCT there is additional uncertainty caused by the use of different reconstruction techniques which will influence contour definition. This work aims to assess both inter- and intra-observer contour variation on average and motion compensated (mid-position) reconstructions. MATERIAL AND METHODS: Eight early stage non-small cell lung cancer patients that received 4DCT were selected and these scans were reconstructed as average and motion compensated datasets...
December 5, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29221313/video-assisted-thoracoscopic-surgery-vats-lower-lobe-bisegmentectomy-s7-8-for-a-central-pulmonary-metastasis
#7
Andreas Hiebinger, Thomas Weik, Horst Mertins, Johannes Bodner
Surgery for pulmonary metastasis is performed heterogeneously with regard to surgical approach [open vs. video-assisted thoracoscopic surgery (VATS)] and resection techniques (e.g., laser enucleation, electro-cautery resection, stapling). Complete tumor resection and preservation of lung parenchyma are of upmost importance. This is technically challenging, especially for central lesions close to vascular and bronchial segmental structures. Thus, simple thoracoscopic wedge resections are often not feasible. A VATS lower lobe bisegmentectomy (S7/8) was performed on a 62-year-old patient with a suspicious pulmonary nodule and a history of hemicolectomy for colorectal carcinoma...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29220858/long-term-successful-closure-of-a-percutaneous-intragastric-trocar-tract-with-crossing-full-thickness-sutures-in-a-porcine-model
#8
Andrew C Storm, Hiroyuki Aihara, Matthew J Skinner, Marvin Ryou, Christopher C Thompson
Background and study aims A novel intragastric trocar placed using a percutaneous endoscopic gastrostomy technique enables the use of laparoscopic tools and procedures, including tissue stapling, cutting, suturing, and retraction. The aim of this porcine study was to determine long-term success of crossing full-thickness sutures in closure of the tract upon trocar withdrawal. Methods 10 trocars were placed in 5 animals. Each animal underwent a standardized tissue resection using a 5-mm stapler under gastroscopic guidance, and two full-thickness, absorbable, crossing sutures were used to close the trocar tracts...
December 8, 2017: Endoscopy
https://www.readbyqxmd.com/read/29220485/funricegenes-dataset-for-comprehensive-understanding-and-application-of-rice-functional-genes
#9
Wen Yao, Guangwei Li, Yiming Yu, Yidan Ouyang
Background: As a main staple food, rice is also a model plant for functional genomic studies of monocots. Decoding of every DNA element of the rice genome is essential for genetic improvement to address increasing food demands. The past 15 years have witnessed extraordinary advances in rice functional genomics. Systematic characterization and proper deposition of every rice gene are vital for both functional studies and crop genetic improvement. Findings: We built a comprehensive and accurate dataset of ∼2,800 functionally characterized rice genes and ∼5,000 members of different gene families, by integrating data from available databases and reviewing of every publication on rice functional genomic studies...
December 4, 2017: GigaScience
https://www.readbyqxmd.com/read/29219968/programmable-self-assembly-of-three-dimensional-nanostructures-from-10-000-unique-components
#10
Luvena L Ong, Nikita Hanikel, Omar K Yaghi, Casey Grun, Maximilian T Strauss, Patrick Bron, Josephine Lai-Kee-Him, Florian Schueder, Bei Wang, Pengfei Wang, Jocelyn Y Kishi, Cameron Myhrvold, Allen Zhu, Ralf Jungmann, Gaetan Bellot, Yonggang Ke, Peng Yin
Nucleic acids (DNA and RNA) are widely used to construct nanometre-scale structures with ever increasing complexity, with possible application in fields such as structural biology, biophysics, synthetic biology and photonics. The nanostructures are formed through one-pot self-assembly, with early kilodalton-scale examples containing typically tens of unique DNA strands. The introduction of DNA origami, which uses many staple strands to fold one long scaffold strand into a desired structure, has provided access to megadalton-scale nanostructures that contain hundreds of unique DNA strands...
December 6, 2017: Nature
https://www.readbyqxmd.com/read/29219963/biotechnological-mass-production-of-dna-origami
#11
Florian Praetorius, Benjamin Kick, Karl L Behler, Maximilian N Honemann, Dirk Weuster-Botz, Hendrik Dietz
DNA nanotechnology, in particular DNA origami, enables the bottom-up self-assembly of micrometre-scale, three-dimensional structures with nanometre-precise features. These structures are customizable in that they can be site-specifically functionalized or constructed to exhibit machine-like or logic-gating behaviour. Their use has been limited to applications that require only small amounts of material (of the order of micrograms), owing to the limitations of current production methods. But many proposed applications, for example as therapeutic agents or in complex materials, could be realized if more material could be used...
December 6, 2017: Nature
https://www.readbyqxmd.com/read/29218712/disposable-skin-staplers-for-closure-of-linear-gastrointestinal-incisions-in-dogs
#12
Zeev Schwartz, Bradley R Coolman
OBJECTIVE: To report the clinical features and outcomes of linear gastrointestinal incisions closed with skin staples in dogs. STUDY DESIGN: Historical cohort study. ANIMALS: 333 client-owned dogs. METHODS: Medical records from 1 private referral hospital were searched for dogs that underwent gastrointestinal surgery between November 1999 and October 2015. Cases were included if skin staplers were used to close linear gastrointestinal incisions...
December 8, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29205150/a-pragmatic-multicentre-randomised-controlled-trial-comparing-stapled-haemorrhoidopexy-with-traditional-excisional-surgery-for-haemorrhoidal-disease-the-ethos-study
#13
Angus Jm Watson, Jonathan Cook, Jemma Hudson, Mary Kilonzo, Jessica Wood, Hanne Bruhn, Steven Brown, Brian Buckley, Finlay Curran, David Jayne, Malcolm Loudon, Ramesh Rajagopal, Alison McDonald, John Norrie
BACKGROUND: Haemorrhoids are a benign anorectal condition and are highly prevalent in the UK population. Treatments involve clinic-based procedures and surgery. The surgical procedures available include stapled haemorrhoidopexy (SH) and traditional haemorrhoidectomy (TH), and over 25,000 operations are performed for haemorrhoids annually in the UK. The disease is therefore important both to patients and to health service commissioners. Debate remains as to which of these surgical procedures is the most clinically effective and cost-effective...
November 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29200604/genetic-impact-of-rht-dwarfing-genes-on-grain-micronutrients-concentration-in-wheat
#14
Govindan Velu, Ravi P Singh, Julio Huerta, Carlos Guzmán
Wheat is a major staple food crop providing about 20% of dietary energy and proteins, and food products made of whole grain wheat are a major source of micronutrients like Zinc (Zn), Iron (Fe), Manganese (Mn), Magnesium (Mg), Vitamin B and E. Wheat provides about 40% intake of essential micronutrients by humans in the developing countries relying on wheat based diets. Varieties with genetically enhanced levels of grain micronutrient concentrations can provide a cost-effective and sustainable option to resource poor wheat consumers...
December 2017: Field Crops Research
https://www.readbyqxmd.com/read/29200311/the-development-and-release-of-maize-fortified-with-provitamin-a-carotenoids-in-developing-countries
#15
Pepukai Manjeru, Angeline Van Biljon, Maryke Labuschagne
Micronutrient deficiencies have been identified as major public health problems affecting a large part of the world's population. Biofortification of staple crops like maize has been proposed as one of the most cost effective and feasible approaches to combat micronutrient deficiencies. Studies have shown that provitamin A from biofortified crops is highly bioavailable and has the capacity to improve vitamin A status of vulnerable groups. Most people in sub-Saharan Africa subsist on maize and many people may benefit from consumption of provitamin A carotenoid biofortified maize, especially women and children...
December 4, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29198281/neuropsychological-assessment-past-and-future
#16
Kaitlin B Casaletto, Robert K Heaton
Neuropsychological assessment tools are the staple of our field. The development of standardized metrics sensitive to brain-behavior relationships has shaped the neuropsychological questions we can ask, our understanding of discrete brain functions, and has informed the detection and treatment of neurological disorders. We identify key turning points and innovations in neuropsychological assessment over the past 40-50 years that highlight how the tools used in common practice today came to be. Also selected for emphasis are several exciting lines of research and novel approaches that are underway to further probe and characterize brain functions to enhance diagnostic and treatment outcomes...
October 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29198168/simultaneous-laparoscopic-proctocolectomy-tatme-and-robot-assisted-radical-prostatectomy-for-synchronous-rectal-and-prostate-cancer
#17
Ben Gys, Karen Fransis, Guy Hubens, Sylvie Van den Broeck, Bart Op de Beeck, Niels Komen
OBJECTIVE: We would like to present a patient with a history of ulcerative colitis suffering from a synchronous rectal and prostate cancer treated with a laparoscopic total proctocolectomy (with TaTME) and Retzius sparing RARP simultaneously. METHODS: Retzius sparing RARP with bilateral lymph node harvesting was performed first. Afterwards, TaTME was commenced with the placement of a Lonestar® retractor and GelPort®. Anterior dissection was troubled unexpectedly by outspoken fibrosis...
December 4, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/29190665/distinctness-of-brazilian-common-bean-cultivars-with-carioca-and-black-grain-by-means-of-morphoagronomic-and-molecular-descriptors
#18
Jessica Delfini, Vânia Moda-Cirino, Claudete de Fátima Ruas, José Dos Santos Neto, Paulo Maurício Ruas, Juliana Sawada Buratto, Eduardo Augusto Ruas, Leandro Simões Azeredo Gonçalves
Common bean (Phaseolus vulgaris L.) is one of the most important legumes for human consumption and is a staple food in the diet of the population of some countries of Latin America, Africa and Asia. The distinction between cultivars is based predominantly on morphological descriptors, which proved inefficient for the differentiation of some cultivars. This study had the objective of describing, distinguishing and evaluating the agronomic potential of 39 common bean cultivars of the carioca and black grain groups registered for cultivation in Brazil, based on 49 morphoagronomic descriptors and microsatellite (simple sequence repeat -SSR) markers...
2017: PloS One
https://www.readbyqxmd.com/read/29190654/prenatal-folic-acid-use-associated-with-decreased-risk-of-myelomeningocele-a-case-control-study-offers-further-support-for-folic-acid-fortification-in-bangladesh
#19
Vijaya Kancherla, Md Omar Sharif Ibne Hasan, Rezina Hamid, Ligi Paul, Jacob Selhub, Godfrey Oakley, Quazi Quamruzzaman, Maitreyi Mazumdar
Neural tube defects contribute to severe morbidity and mortality in children and adults; however, they are largely preventable through maternal intake of folic acid before and during early pregnancy. We examined the association between maternal prenatal folic acid supplement intake and risk of myelomeningocele (a severe and common type of neural tube defect) in the offspring. We performed secondary analysis using data from a case-control study conducted at Dhaka Community Hospital, Bangladesh between April and November of 2013...
2017: PloS One
https://www.readbyqxmd.com/read/29190038/closure-methods-of-the-appendix-stump-for-complications-during-laparoscopic-appendectomy
#20
REVIEW
Gurdeep S Mannu, Maria K Sudul, Joao H Bettencourt-Silva, Elspeth Cumber, Fangfang Li, Allan B Clark, Yoon K Loke
BACKGROUND: Laparoscopic appendectomy is amongst the most common general surgical procedures performed in the developed world. Arguably, the most critical part of this procedure is effective closure of the appendix stump to prevent catastrophic intra-abdominal complications from a faecal leak into the abdominal cavity. A variety of methods to close the appendix stump are used worldwide; these can be broadly divided into traditional ligatures (such as intracorporeal or extracorporeal ligatures or Roeder loops) and mechanical devices (such as stapling devices, clips, or electrothermal devices)...
November 13, 2017: Cochrane Database of Systematic Reviews
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