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https://www.readbyqxmd.com/read/28634033/nickel-sulfate-promotes-il-17a-producing-cd4-t-cells-by-an-il-23-dependent-mechanism-regulated-by-tlr4-and-jak-stat-pathways
#1
Rami Bechara, Diane Antonios, Hayat Azouri, Marc Pallardy
Allergic contact dermatitis, caused by nickel, is a delayed-type hypersensitivity reaction and 14.5% of the general population may be affected in Europe. Among a wide range of cytokines, the IL-12 family has unique structural and immunological characteristics. While IL-12p70 promotes T helper (Th) 1 cells polarization, IL-23 promotes Th17 cells development and both have been isolated from nickel-allergic patients. In this work, we were interested in understanding the mechanism behind nickel-induced Th17 cells development...
June 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28633806/il-17-for-therapy
#2
REVIEW
Florian C Kurschus, Sonja Moos
The cytokine IL-17 is now a target for an array of therapeutic monoclonal antibodies supposed to treat a variety of inflammatory diseases. The forerunner Secukinumab, an IL-17A neutralizing antibody, is meanwhile approved as first-line treatments for moderate-to-severe plaque psoriasis, and as second-line treatment for psoriatic arthritis and ankylosing spondylitis. Ixekizumab and Brodalumab, both also targeting the IL-17 pathway, were also recently approved by the FDA for plaque psoriasis. Using mice overexpressing IL-17A in a tissue of choice, we showed that the ectopic expression of this cytokine in keratinocytes resulted in a spontaneous and very strong form of psoriasis-like dermatitis...
June 15, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28633739/autoimmune-progesterone-dermatitis-presenting-as-fixed-drug-eruption-a-case-report
#3
Raya Mokhtari, Mozhdeh Sepaskhah, Fatemeh Sari Aslani, Ladan Dastgheib
Autoimmune progesterone dermatitis (APD) is a rare disorder characterized by periodic skin lesions that erupt during the luteal phase of the menstrual cycle. Clinical manifestations of APD is caused by an unusual allergy to progesterone and has a wide range of clinical manifestations from eczema and urticaria to angioedema and erythema multiforme. A 46-year-old woman described recurrent, round erythematous plaques on the lower lip, both forearms and buttocks. These skin eruptions waxed and waned for 10 months, reoccurring 3-4 days before menstruation...
June 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28632956/anti-inflammatory-potential-of-a-heat-killed-lactobacillus-strain-isolated-from-kimchi-on-house-dust-mite-induced-atopic-dermatitis-in-nc-nga-mice
#4
C Y Choi, Y H Kim, S Oh, H J Lee, J H Kim, S H Park, H J Kim, S J Lee, T Chun
AIMS: Atopic dermatitis (AD) is an allergic skin disease driven by the Th2-prone immune response. Therefore, a fundamental approach to restoring the Th1/Th2 balance is needed to treat AD. METHODS AND RESULTS: Eighteen different Lactobacillus strains isolated from Kimchi were screened to identify those that stimulated immune cells to secret Th1-type or Th2-type cytokines. Lactobacillus brevis NS1401 induced the greatest IFN-γ and IL-12 secretion and the least IL-4 production among the tested Lactobacillus strains...
June 20, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28632893/atopic-dermatitis-is-associated-with-anxiety-depression-and-suicidal-ideation-but-not-with-hospitalization-or-suicide
#5
Jacob P Thyssen, Carsten R Hamann, Allan Linneberg, Thomas Meinertz Dantoft, Lone Skov, Gunnar H Gislason, Jashin J Wu, Alexander Egeberg
BACKGROUND: Atopic dermatitis (AD) has been linked with psychiatric disease in adults. However, the exact relationship and its consequences have been insufficiently studied. Our aim in this study was to assess the association between depression, anxiety and AD in adults, and examine the risk of hospitalization and suicide. METHODS: We utilized questionnaire data from a large general population study with data on social habits and psychiatric symptoms to compare prevalences of depression, anxiety, suicidal ideation, and anxiety attacks, in adults with and without a history of AD...
June 20, 2017: Allergy
https://www.readbyqxmd.com/read/28632803/what-s-eating-you-cheyletiella-mites
#6
H Harris Reynolds, Dirk M Elston
Cheyletiella are nonburrowing mites commonly found on rabbits, dogs, and cats. The mites have been known to cause disease in humans, ranging from mild dermatitis to more severe illness with systemic symptoms. Because these mites do not complete any part of their life cycle in humans, diagnosis can be challenging. Herein, we review various clinical presentations associated with Cheyletiella mites as well as diagnostic techniques and treatment options for both humans and animals.
May 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28632331/the-validity-of-register-data-to-identify-children-with-atopic-dermatitis-asthma-or-allergic-rhinoconjunctivitis
#7
Lone Graff Stensballe, Lotte Klansø, Andreas Jensen, Ann Haerskjold, Simon Francis Thomsen, Jacob Simonsen
BACKGROUND: The incidence of atopic dermatitis, wheezing, asthma and allergic rhinoconjunctivitis have been increasing. Register-based studies are essential for research in subpopulations with specific diseases, and facilitate epidemiological studies to identify causes and evaluate interventions. Algorithms have been developed to identify children with atopic dermatitis, asthma or allergic rhinoconjunctivitis using register information on disease-specific dispensed prescribed medication and hospital contacts, but the validity of the algorithms has not been evaluated...
June 20, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28632093/allergic-contact-dermatitis-from-ophthalmics
#8
Yue Zheng, Paru R Chaudhari, Howard I Maibach
In this article we summarize the recently described allergens responsible for allergic contact dermatitis due to ophthalmic drugs and contact lens solutions, and emphaage the need on how to perform diagnostic testing in this special clinical entity.
March 6, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28631871/efficacy-of-percutaneous-endoscopic-gastro-jejunostomy-peg-j-decompression-therapy-for-patients-with-chronic-intestinal-pseudo-obstruction-cipo
#9
H Ohkubo, A Fuyuki, J Arimoto, T Higurashi, T Nonaka, Y Inoh, H Iida, M Inamori, T Kaneda, A Nakajima
BACKGROUNDS: Chronic intestinal pseudo-obstruction (CIPO) is an intractable rare digestive disease manifesting persistent small bowel distension without any mechanical cause. Intestinal decompression is a key treatment, but conventional method including a trans-nasal small intestinal tube is invasive and painful. Therefore, a less invasive and tolerable new decompression method is urgently desired. We conducted a pilot study and assessed the efficacy and safety of percutaneous endoscopic gastro-jejunostomy (PEG-J) decompression therapy in CIPO patients...
June 20, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28631851/an-association-between-periostin-levels-with-the-severity-and-chronicity-of-atopic-dermatitis-in-children
#10
Myongsoon Sung, Kyung Suk Lee, Eun Gyo Ha, Seung Jin Lee, Mi Ae Kim, Seung Won Lee, Hye Mi Jee, Youn Ho Shin, Young Ho Jung, Man Yong Han
BACKGROUND: Serum periostin might be a biomarker of the pathogenesis of T helper 2-type allergic diseases. The aim of this study is to investigate the relationship between serum periostin levels and the severity and chronicity of atopic dermatitis (AD) in children. METHODS: This population-based study examined 4,076 children from aged 4 to 13 years between June 2015 and July 2015. Of the 4,076 children, 196 including 137 with a history of AD in the AD group and 59 without allergic diseases history in the healthy control (HC) group were included for the final analysis...
June 20, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28631848/impact-of-solar-ultraviolet-radiation-on-atopic-dermatitis-symptoms-in-young-children-a-longitudinal-study
#11
Young-Min Kim, Jihyun Kim, Ji Young Lee, Minji Kim, Hyunmi Kim, Kwon Jung, Soomi Eo, Mijin Ahn, Kangmo Ahn
BACKGROUND: There are controversial data about the effects of sun exposure on atopic dermatitis (AD). We evaluated the association between solar ultraviolet radiation (UVR) exposure and AD symptoms in children. METHODS: Eighty two children under 6 years (48 boys and 34 girls) with AD living in Seoul, Korea were enrolled and followed for 12 months between September 2013 and August 2014. Daily symptoms were recorded to describe the degree of itching, sleep disturbance, erythema, dryness, oozing and edema...
June 20, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28631812/identification-of-allergens-by-ige-specific-testing-improves-outcomes-in-atopic-dermatitis
#12
Brett M Will, Richard Severino, Douglas W Johnson
INTRODUCTION: IgE quantitative assaying of allergens (IgEQAA) has long been implemented by allergists in determining patients' reactivities for allergic rhinitis and asthma, two of the three diagnoses in atopic syndrome. This test operates by measuring the patient's IgE response to different allergens and can identify potential triggers for a patient's symptoms. Despite this, IgEQAA has yet to see the same widespread use in the field of dermatology, specifically in the treatment of patients with atopic dermatitis (AD)...
June 20, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28630805/dermatitis-herpetiformis-as-the-initial-presentation-of-primary-biliary-cholangitis-in-a-male-with-gluten-sensitivity
#13
Cyriac Philips, Rajaguru Paramaguru, Divya A Indiran, Philip Augustine
Celiac disease is commonly associated with elevated liver enzymes that normalize on a gluten-free diet. Celiac disease is rarely described in patients with primary biliary cholangitis. Dermatitis herpetiformis is the skin manifestation of the celiac disease that is very rarely associated with primary biliary cirrhosis. We present the case of a 62-year-old man who presented with severe chronic pruritus, in whom a diagnosis of primary biliary cholangitis was made initially. However, in the presence of atypical skin lesions, not confirming to chronic cholestasis, an in-depth evaluation including histopathological examination led to the diagnosis of dermatitis herpetiformis associated with gluten sensitivity...
May 14, 2017: Curēus
https://www.readbyqxmd.com/read/28629748/patterns-and-predictors-of-atopic-dermatitis-disease-control-past-childhood-an-observational-cohort-study
#14
Katrina Abuabara, Ole Hoffstad, Andrea B Troxel, Joel M Gelfand, Charles E McCulloch, David J Margolis
Individuals experience distinct patterns of atopic dermatitis disease control over time; female sex, lower income, non-white race, atopic history and earlier age of onset were highly predictive of persistently active disease into early adulthood.
June 16, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28629743/association-study-of-childhood-food-allergy-with-gwas-discovered-loci-of-atopic-dermatitis-and-eosinophilic-esophagitis
#15
Tomomitsu Hirota, Tsuguhisa Nakayama, Sakura Sato, Noriyuki Yanagida, Teruaki Matsui, Shiro Sugiura, Yuri Takaoka, Nobuyuki Hizawa, Shigeharu Fujieda, Akihiko Miyatake, Takashi Sasaki, Masayuki Amagai, Satoru Doi, Komei Ito, Motohiro Ebisawa, Mayumi Tamari
We found associations between FA and 14 GWAS-identified loci of AD and EoE: C11orf30/LRRC32, TMEM232/SLC25A46, TNFRSF6B/ZGPAT, OVOL1, KIF3A/IL13, GLB1, CCDC80, ZNF365, OR10A3/NLRP10, IL2/IL21, CLEC16A/DEXI, ZNF652, TSLP/WDR36 and STAT6. These findings improve our understanding of the complex heterogeneity of FA.
June 16, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28629299/farm-and-cow-level-prevalence-of-bovine-digital-dermatitis-on-dairy-farms-in-taranaki-new-zealand
#16
D A Yang, C Heuer, R Laven, W D Vink, R N Chesterton
AIMS: This aim of this cross-sectional study was to investigate the herd and cow-level prevalence of bovine digital dermatitis (BDD) in dairy farms in the northern Taranaki region of New Zealand, and to identify whether there was any spatial clustering of herds with the disease. METHODS: A survey of 224 dairy farms in the northern Taranaki region of New Zealand was undertaken from September 2014 to February 2015. Following training in robust criteria to confirm BDD visually, a technician inspected the rear feet of every milking cow on the farms during milking...
June 19, 2017: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/28628236/blastomyces-dermatitidis-peritonitis-complicating-peritoneal-dialysis
#17
Yogesh Sanghvi, Douglas Somers
Fungal peritonitis is an uncommon complication in peritoneal dialysis patients. We report a case of blastomyces dermatitis peritonitis in a nonimmunocompromised peritoneal dialysis patient, who initially presented with symptoms of lower extremity weakness and altered mental status. Peritoneal blastomycosis is rare condition and not previously reported in end stage renal disease patients on peritoneal dialysis. Fungal peritonitis can present with subtle clinical findings so a high index of suspicion is needed as early detection and treatment may decrease mortality and morbidity...
June 19, 2017: Seminars in Dialysis
https://www.readbyqxmd.com/read/28628108/germline-hypomorphic-card11-mutations-in-severe-atopic-disease
#18
Chi A Ma, Jeffrey R Stinson, Yuan Zhang, Jordan K Abbott, Michael A Weinreich, Pia J Hauk, Paul R Reynolds, Jonathan J Lyons, Celeste G Nelson, Elisa Ruffo, Batsukh Dorjbal, Salomé Glauzy, Natsuko Yamakawa, Swadhinya Arjunaraja, Kelsey Voss, Jennifer Stoddard, Julie Niemela, Yu Zhang, Sergio D Rosenzweig, Joshua J McElwee, Thomas DiMaggio, Helen F Matthews, Nina Jones, Kelly D Stone, Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti, Brian Kim, Megan A Cooper, Neil D Romberg, Eric Meffre, Erwin W Gelfand, Andrew L Snow, Joshua D Milner
Few monogenic causes for severe manifestations of common allergic diseases have been identified. Through next-generation sequencing on a cohort of patients with severe atopic dermatitis with and without comorbid infections, we found eight individuals, from four families, with novel heterozygous mutations in CARD11, which encodes a scaffolding protein involved in lymphocyte receptor signaling. Disease improved over time in most patients. Transfection of mutant CARD11 expression constructs into T cell lines demonstrated both loss-of-function and dominant-interfering activity upon antigen receptor-induced activation of nuclear factor-κB and mammalian target of rapamycin complex 1 (mTORC1)...
June 19, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28627593/suppressive-effect-of-an-aqueous-extract-of-diospyros-kaki-calyx-on-dust-mite-extract-2-4-dinitrochlorobenzene-induced-atopic-dermatitis-like-skin-lesions
#19
Ju-Hee Yu, Meiling Jin, Young-Ae Choi, Na-Hee Jeong, Jeong-Sook Park, Tae-Yong Shin, Sang-Hyun Kim
Atopic dermatitis (AD) is a common chronic inflammatory skin disease, affecting 10-20% of individuals worldwide. Therefore, the discovery of drugs for treating AD is an attractive subject and important to human health. Diospyros kaki and Diospyros kaki (D. kaki) folium exert beneficial effects on allergic inflammation. However, the effect of D. kaki calyx on AD remains elusive. The present study evaluated the effects of an aqueous extract of D. kaki calyx (AEDKC) on AD-like skin lesions using mouse and keratinocyte models...
June 12, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28627284/treatment-of-neotrombicula-species-infestation-in-cats-using-a-10-w-v-fipronil-topical-spot-on-formulation-a-pilot-study
#20
Marie C Cadiergues, Christelle Navarro, Eloy Castilla-Castaño, Line A Lecru, Charline Pressanti
Objectives Few data are available concerning therapeutic aspects of feline trombiculiasis. This study evaluated the efficacy of a 10% w/v fipronil-based spot-on solution in 15 cats with natural Neotrombicula species infestation. Methods Ten cats received 1 drop per affected site on day (D)0 and D14, with the rest of the 0.5 ml pipette applied on the skin between the shoulders. Five cats served as non-treated controls. Parasite score (0 = absent; 3 = severe, >10 parasites/zone) was assessed on D0, D14 and D28 on all animals...
June 1, 2017: Journal of Feline Medicine and Surgery
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